                         SEQUENCE LISTING

<110>  CSIR-Institute of Genomics and Integrative Biology
 
<120>  KINETICALLY ENHANCED FnCAS9 AND ITS USES THEREOF

<130>  -

<160>  305   

<170>  PatentIn version 3.5

<210>  1
<211>  1629
<212>  PRT
<213>  Francisella novicida

<400>  1

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  2
<211>  1629
<212>  PRT
<213>  synthetic

<400>  2

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Arg Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  3
<211>  1629
<212>  PRT
<213>  synthetic

<400>  3

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn His Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  4
<211>  1629
<212>  PRT
<213>  synthetic

<400>  4

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Arg Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn His Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  5
<211>  1629
<212>  PRT
<213>  synthetic

<400>  5

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Thr Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  6
<211>  1629
<212>  PRT
<213>  synthetic

<400>  6

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Tyr Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  7
<211>  1629
<212>  PRT
<213>  synthetic

<400>  7

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Arg Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  8
<211>  1629
<212>  PRT
<213>  synthetic

<400>  8

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Lys Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  9
<211>  1629
<212>  PRT
<213>  synthetic

<400>  9

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Arg Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  10
<211>  1629
<212>  PRT
<213>  synthetic

<400>  10

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Tyr Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  11
<211>  1630
<212>  PRT
<213>  synthetic

<400>  11

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Val Phe Leu Val  Lys Arg Lys 
    1445                 1450                 1455             


Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile Leu Asn  Asp Ser Asp 
    1460                 1465                 1470             


Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile Pro Ala  Phe Asp Ile 
    1475                 1480                 1485             


Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile Asp Ser  Phe Thr Ser 
    1490                 1495                 1500             


Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile Glu Leu  Gln Lys Val 
    1505                 1510                 1515             


Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr Ser Lys  Trp Phe Glu 
    1520                 1525                 1530             


Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile Gly Ile  Ala Thr Ile 
    1535                 1540                 1545             


Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro Lys Val  Arg Val Lys 
    1550                 1555                 1560             


Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys Ile Asn  Tyr Phe Met 
    1565                 1570                 1575             


Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro Asp Lys  Val Leu Glu 
    1580                 1585                 1590             


Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe Glu Ser  Ser Gly Phe 
    1595                 1600                 1605             


Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met Lys Leu  Ala Gly Ile 
    1610                 1615                 1620             


Tyr Asn  Glu Thr Ser Asn Asn  
    1625                 1630 


<210>  12
<211>  1629
<212>  PRT
<213>  synthetic

<400>  12

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Thr 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  13
<211>  1629
<212>  PRT
<213>  synthetic

<400>  13

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Val Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  14
<211>  1629
<212>  PRT
<213>  synthetic

<400>  14

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  His Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  15
<211>  1629
<212>  PRT
<213>  synthetic

<400>  15

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Arg Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  16
<211>  1629
<212>  PRT
<213>  synthetic

<400>  16

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe His Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  17
<211>  1629
<212>  PRT
<213>  synthetic

<400>  17

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Arg Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn His Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Thr Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  18
<211>  1629
<212>  PRT
<213>  synthetic

<400>  18

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Tyr Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  19
<211>  1629
<212>  PRT
<213>  synthetic

<400>  19

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Phe  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  20
<211>  1629
<212>  PRT
<213>  synthetic

<400>  20

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp His Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  21
<211>  1629
<212>  PRT
<213>  synthetic

<400>  21

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Arg  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  22
<211>  1629
<212>  PRT
<213>  synthetic

<400>  22

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Arg Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  23
<211>  1629
<212>  PRT
<213>  synthetic

<400>  23

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Val Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  24
<211>  1629
<212>  PRT
<213>  synthetic

<400>  24

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Ser Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  25
<211>  1629
<212>  PRT
<213>  synthetic

<400>  25

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Asn Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  26
<211>  1629
<212>  PRT
<213>  synthetic

<400>  26

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Phe  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  27
<211>  1629
<212>  PRT
<213>  synthetic

<400>  27

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Arg  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  28
<211>  1630
<212>  PRT
<213>  synthetic

<400>  28

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Arg Ser Asn Phe  Ile Ile Gly Lys Ile  Thr Leu Pro 
    1385                 1390                 1395             


Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg Glu Trp  Gln Asn Thr 
    1400                 1405                 1410             


Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys Ser Phe  Phe Asn Val 
    1415                 1420                 1425             


Lys Ser  Ile Thr Lys Leu His  Lys Lys Val Arg Lys  Asp Phe Ser 
    1430                 1435                 1440             


Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe Leu Val  Lys Arg Lys 
    1445                 1450                 1455             


Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile Leu Asn  Asp Ser Asp 
    1460                 1465                 1470             


Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile Pro Ala  Phe Asp Ile 
    1475                 1480                 1485             


Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile Asp Ser  Phe Thr Ser 
    1490                 1495                 1500             


Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile Glu Leu  Gln Lys Val 
    1505                 1510                 1515             


Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr Ser Lys  Trp Phe Glu 
    1520                 1525                 1530             


Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile Gly Ile  Ala Thr Ile 
    1535                 1540                 1545             


Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro Lys Val  Arg Val Lys 
    1550                 1555                 1560             


Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys Ile Asn  Tyr Phe Met 
    1565                 1570                 1575             


Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro Asp Lys  Val Leu Glu 
    1580                 1585                 1590             


Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe Glu Ser  Ser Gly Phe 
    1595                 1600                 1605             


Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met Lys Leu  Ala Gly Ile 
    1610                 1615                 1620             


Tyr Asn  Glu Thr Ser Asn Asn  
    1625                 1630 


<210>  29
<211>  1629
<212>  PRT
<213>  synthetic

<400>  29

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  His Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe His Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  30
<211>  1629
<212>  PRT
<213>  synthetic

<400>  30

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Lys Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Tyr Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  31
<211>  1629
<212>  PRT
<213>  synthetic

<400>  31

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Thr Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Arg Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn His Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  32
<211>  1629
<212>  PRT
<213>  synthetic

<400>  32

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Arg Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Lys Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn His Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  33
<211>  1629
<212>  PRT
<213>  synthetic

<400>  33

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Arg Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Tyr His Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  34
<211>  1629
<212>  PRT
<213>  synthetic

<400>  34

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Arg Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe His Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  35
<211>  1629
<212>  PRT
<213>  synthetic

<400>  35

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Arg Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Lys Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  36
<211>  1629
<212>  PRT
<213>  synthetic

<400>  36

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Arg Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Arg Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  37
<211>  1629
<212>  PRT
<213>  synthetic

<400>  37

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Arg Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Tyr Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  38
<211>  1629
<212>  PRT
<213>  synthetic

<400>  38

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Arg Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Phe  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  39
<211>  1629
<212>  PRT
<213>  synthetic

<400>  39

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Arg Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Arg  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  40
<211>  1629
<212>  PRT
<213>  synthetic

<400>  40

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Thr Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Arg Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  41
<211>  1629
<212>  PRT
<213>  synthetic

<400>  41

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Arg Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Gln Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  42
<211>  1629
<212>  PRT
<213>  synthetic

<400>  42

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Lys Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe His Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  43
<211>  1629
<212>  PRT
<213>  synthetic

<400>  43

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Arg Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe His Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  44
<211>  1629
<212>  PRT
<213>  synthetic

<400>  44

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Tyr Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe His Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  45
<211>  1629
<212>  PRT
<213>  synthetic

<400>  45

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Phe  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe His Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  46
<211>  1629
<212>  PRT
<213>  synthetic

<400>  46

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Arg  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe His Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  47
<211>  1629
<212>  PRT
<213>  synthetic

<400>  47

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Thr Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe His Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  48
<211>  1629
<212>  PRT
<213>  synthetic

<400>  48

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Gln Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe His Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  49
<211>  1628
<212>  PRT
<213>  synthetic

<400>  49

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Gln Lys Val Arg Val  Lys Leu Asp 
    1550                 1555                 1560             


Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn Tyr Phe  Met Asn His 
    1565                 1570                 1575             


Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys Val Leu  Glu Ile Leu 
    1580                 1585                 1590             


Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser Ser Gly  Phe Asn Lys 
    1595                 1600                 1605             


Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu Ala Gly  Ile Tyr Asn 
    1610                 1615                 1620             


Glu Thr  Ser Asn Asn 
    1625             


<210>  50
<211>  1629
<212>  PRT
<213>  synthetic

<400>  50

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Arg Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn His Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Gln Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  51
<211>  1447
<212>  PRT
<213>  synthetic

<400>  51

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Arg Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  52
<211>  1447
<212>  PRT
<213>  synthetic

<400>  52

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn His Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  53
<211>  1447
<212>  PRT
<213>  synthetic

<400>  53

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Arg Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn His Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  54
<211>  1447
<212>  PRT
<213>  synthetic

<400>  54

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Thr Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  55
<211>  1447
<212>  PRT
<213>  synthetic

<400>  55

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Tyr Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  56
<211>  1447
<212>  PRT
<213>  synthetic

<400>  56

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Arg  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  57
<211>  1447
<212>  PRT
<213>  synthetic

<400>  57

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Lys  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  58
<211>  1447
<212>  PRT
<213>  syntehtic

<400>  58

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Arg Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  59
<211>  1447
<212>  PRT
<213>  synthetic

<400>  59

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Tyr Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  60
<211>  1448
<212>  PRT
<213>  synthetic

<400>  60

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Val  Phe Leu Val Lys Arg  Lys Thr Trp 
    1265                 1270                 1275             


Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn Asp Ser  Asp Ser Arg 
    1280                 1285                 1290             


Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala Phe Asp  Ile Ser Lys 
    1295                 1300                 1305             


Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser Phe Thr  Ser Lys Asn 
    1310                 1315                 1320             


Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu Gln Lys  Val Asp Asn 
    1325                 1330                 1335             


Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys Trp Phe  Glu Val Glu 
    1340                 1345                 1350             


Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile Ala Thr  Ile Gln Tyr 
    1355                 1360                 1365             


Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val Arg Val  Lys Leu Asp 
    1370                 1375                 1380             


Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn Tyr Phe  Met Asn His 
    1385                 1390                 1395             


Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys Val Leu  Glu Ile Leu 
    1400                 1405                 1410             


Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser Ser Gly  Phe Asn Lys 
    1415                 1420                 1425             


Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu Ala Gly  Ile Tyr Asn 
    1430                 1435                 1440             


Glu Thr  Ser Asn Asn 
    1445             


<210>  61
<211>  1447
<212>  PRT
<213>  synthetic

<400>  61

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Thr Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  62
<211>  1447
<212>  PRT
<213>  synthetic

<400>  62

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Val Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  63
<211>  1447
<212>  PRT
<213>  synthetic

<400>  63

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg His Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  64
<211>  1447
<212>  PRT
<213>  synthetic

<400>  64

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Arg Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  65
<211>  1447
<212>  PRT
<213>  synthetic

<400>  65

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  His Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  66
<211>  1447
<212>  PRT
<213>  synthetic

<400>  66

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Arg Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn His Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Thr Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  67
<211>  1447
<212>  PRT
<213>  synthetic

<400>  67

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Tyr Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  68
<211>  1447
<212>  PRT
<213>  synthetic

<400>  68

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Phe 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  69
<211>  1447
<212>  PRT
<213>  synthetic

<400>  69

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp His Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  70
<211>  1447
<212>  PRT
<213>  synthetic

<400>  70

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Arg 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  71
<211>  1447
<212>  PRT
<213>  synthetic

<400>  71

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Arg Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  72
<211>  1447
<212>  PRT
<213>  synthetic

<400>  72

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Val Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  73
<211>  1447
<212>  PRT
<213>  synthetic

<400>  73

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Ser Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  74
<211>  1447
<212>  PRT
<213>  synthetic

<400>  74

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Asn Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  75
<211>  1447
<212>  PRT
<213>  synthetic

<400>  75

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Phe Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  76
<211>  1447
<212>  PRT
<213>  synthetic

<400>  76

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Arg Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  77
<211>  1448
<212>  PRT
<213>  synthetic

<400>  77

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Arg  Ser Asn Phe Ile Ile  Gly Lys Ile Thr Leu  Pro Phe Lys 
    1205                 1210                 1215             


Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp Gln Asn  Thr Thr Ile 
    1220                 1225                 1230             


Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe Phe Asn  Val Lys Ser 
    1235                 1240                 1245             


Ile Thr  Lys Leu His Lys Lys  Val Arg Lys Asp Phe  Ser Leu Pro 
    1250                 1255                 1260             


Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val Lys Arg  Lys Thr Trp 
    1265                 1270                 1275             


Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn Asp Ser  Asp Ser Arg 
    1280                 1285                 1290             


Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala Phe Asp  Ile Ser Lys 
    1295                 1300                 1305             


Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser Phe Thr  Ser Lys Asn 
    1310                 1315                 1320             


Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu Gln Lys  Val Asp Asn 
    1325                 1330                 1335             


Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys Trp Phe  Glu Val Glu 
    1340                 1345                 1350             


Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile Ala Thr  Ile Gln Tyr 
    1355                 1360                 1365             


Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val Arg Val  Lys Leu Asp 
    1370                 1375                 1380             


Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn Tyr Phe  Met Asn His 
    1385                 1390                 1395             


Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys Val Leu  Glu Ile Leu 
    1400                 1405                 1410             


Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser Ser Gly  Phe Asn Lys 
    1415                 1420                 1425             


Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu Ala Gly  Ile Tyr Asn 
    1430                 1435                 1440             


Glu Thr  Ser Asn Asn 
    1445             


<210>  78
<211>  1447
<212>  PRT
<213>  synthetic

<400>  78

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg His Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  His Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  79
<211>  1447
<212>  PRT
<213>  synthetic

<400>  79

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Lys  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Tyr Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  80
<211>  1447
<212>  PRT
<213>  synthetic

<400>  80

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Thr Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Arg Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn His Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  81
<211>  1447
<212>  PRT
<213>  synthetic

<400>  81

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Arg Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Lys  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn His Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  82
<211>  1447
<212>  PRT
<213>  synthetic

<400>  82

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Arg Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Tyr His Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  83
<211>  1447
<212>  PRT
<213>  synthetic

<400>  83

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Arg Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  His Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  84
<211>  1447
<212>  PRT
<213>  synthetic

<400>  84

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Arg Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Lys  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  85
<211>  1447
<212>  PRT
<213>  synthetic

<400>  85

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Arg Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Arg Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  86
<211>  1447
<212>  PRT
<213>  synthetic

<400>  86

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Arg Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Tyr Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  87
<211>  1447
<212>  PRT
<213>  synthetic

<400>  87

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Arg Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Phe 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  88
<211>  1447
<212>  PRT
<213>  synthetic FnCas9 delREC2

<400>  88

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Arg Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Arg 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  89
<211>  1447
<212>  PRT
<213>  synthetic

<400>  89

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Thr Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Arg Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  90
<211>  1447
<212>  PRT
<213>  synthetic

<400>  90

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Arg Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Gln Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  91
<211>  1629
<212>  PRT
<213>  synthetic

<400>  91

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Lys Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe His Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  92
<211>  1447
<212>  PRT
<213>  synthetic

<400>  92

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Arg Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  His Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  93
<211>  1447
<212>  PRT
<213>  synthetic

<400>  93

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Tyr Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  His Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  94
<211>  1447
<212>  PRT
<213>  synthetic

<400>  94

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Phe 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  His Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  95
<211>  1447
<212>  PRT
<213>  synthetic

<400>  95

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Arg 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  His Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  96
<211>  1447
<212>  PRT
<213>  synthetic

<400>  96

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Thr Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Arg Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  His Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  97
<211>  1447
<212>  PRT
<213>  synthetic

<400>  97

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Gln Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  His Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  98
<211>  1446
<212>  PRT
<213>  synthetic

<400>  98

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Glu Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn Glu Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Gln Lys  Val Arg Val Lys Leu  Asp Tyr Val 
    1370                 1375                 1380             


Ile Asp  Asp Asp Ser Lys Ile  Asn Tyr Phe Met Asn  His Ser Leu 
    1385                 1390                 1395             


Leu Lys  Ser Arg Tyr Pro Asp  Lys Val Leu Glu Ile  Leu Lys Gln 
    1400                 1405                 1410             


Ser Thr  Ile Ile Glu Phe Glu  Ser Ser Gly Phe Asn  Lys Thr Ile 
    1415                 1420                 1425             


Lys Glu  Met Leu Gly Met Lys  Leu Ala Gly Ile Tyr  Asn Glu Thr 
    1430                 1435                 1440             


Ser Asn  Asn 
    1445     


<210>  99
<211>  1447
<212>  PRT
<213>  synthetic

<400>  99

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Gly 
            100                 105                 110         


Gly Gly Ser Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly Arg 
        115                 120                 125             


His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu Asn 
    130                 135                 140                 


Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His Asn 
145                 150                 155                 160 


Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile Gly 
                165                 170                 175     


Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp 
            180                 185                 190         


Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr Glu 
        195                 200                 205             


Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys Asp 
    210                 215                 220                 


Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu Leu 
                245                 250                 255     


Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn 
            260                 265                 270         


Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu 
        275                 280                 285             


Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys 
305                 310                 315                 320 


Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser 
                325                 330                 335     


Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp 
            340                 345                 350         


Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu 
        355                 360                 365             


Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys 
    370                 375                 380                 


Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu 
385                 390                 395                 400 


Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Thr 
                405                 410                 415     


Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr 
            420                 425                 430         


Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro 
        435                 440                 445             


Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys Tyr Asn Asn Thr Gly Arg 
    450                 455                 460                 


Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg 
465                 470                 475                 480 


Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val 
                485                 490                 495     


Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe 
            500                 505                 510         


Ile Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys 
        515                 520                 525             


Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His 
    530                 535                 540                 


Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn 
                565                 570                 575     


Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu 
            580                 585                 590         


Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp Arg Lys Ile Lys Lys Phe 
        595                 600                 605             


Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu 
    610                 615                 620                 


Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala 
625                 630                 635                 640 


His Arg Met Gln Gln Ile Lys Ile Thr Glu Pro Val Glu Asp Asn Lys 
                645                 650                 655     


Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro 
            660                 665                 670         


Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu Ala 
        675                 680                 685             


Lys Asn Ile Val Asp Asp Asn Trp Gln Asn Ile Lys Gln Val Leu Ser 
    690                 695                 700                 


Ala Lys His Gln Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe 
705                 710                 715                 720 


Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys Asp 
                725                 730                 735     


Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys 
            740                 745                 750         


Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr 
        755                 760                 765             


Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu 
    770                 775                 780                 


Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn 
785                 790                 795                 800 


Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn Lys Asn Lys 
                805                 810                 815     


Gly Asn Arg Ile Phe Cys Leu Arg Asp Leu Ala Asp Asn Tyr Lys Leu 
            820                 825                 830         


Lys Gln Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile Ala 
        835                 840                 845             


Asp Thr Ile Trp Asp Ala Asn Lys Lys Asp Phe Lys Phe Gly Asn Tyr 
    850                 855                 860                 


Arg Ser Phe Ile Asn Leu Thr Pro Gln Glu Gln Lys Ala Phe Arg His 
865                 870                 875                 880 


Ala Leu Phe Leu Ala Asp Glu Asn Pro Ile Lys Gln Ala Val Ile Arg 
                885                 890                 895     


Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gln Arg Tyr 
            900                 905                 910         


Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys Glu 
        915                 920                 925             


Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro Thr 
    930                 935                 940                 


Ile Gly Asn Gly Arg Gly Ile Ala Glu Ile Arg Gln Leu Tyr Glu Lys 
945                 950                 955                 960 


Val Asp Ser Asp Ile Gln Ala Tyr Ala Lys Gly Asp Lys Pro Gln Ala 
                965                 970                 975     


Ser Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala 
            980                 985                 990         


Asp Glu His Arg Asn Asp Gly Ser  Ile Gly Leu Glu Ile  Asp Lys Asn 
        995                 1000                 1005             


Tyr Ser  Leu Tyr Pro Leu Asp  Lys Asn Thr Gly Glu  Val Phe Thr 
    1010                 1015                 1020             


Lys Asp  Ile Phe Ser Gln Ile  Lys Ile Thr Asp Asn  Glu Phe Ser 
    1025                 1030                 1035             


Asp Lys  Lys Leu Val Arg Lys  Lys Ala Ile Glu Gly  Phe Asn Thr 
    1040                 1045                 1050             


His Arg  Gln Met Thr Arg Asp  Gly Ile Tyr Ala Glu  Asn Tyr Leu 
    1055                 1060                 1065             


Pro Ile  Leu Ile His Lys Glu  Leu Asn Glu Val Arg  Lys Gly Tyr 
    1070                 1075                 1080             


Thr Trp  Lys Asn Ser Glu Glu  Ile Lys Ile Phe Lys  Gly Lys Lys 
    1085                 1090                 1095             


Tyr Asp  Ile Gln Gln Leu Asn  Asn Leu Val Tyr Cys  Leu Lys Phe 
    1100                 1105                 1110             


Val Asp  Lys Pro Ile Ser Ile  Asp Ile Gln Ile Ser  Thr Leu Glu 
    1115                 1120                 1125             


Glu Leu  Arg Asn Ile Leu Thr  Thr Asn Asn Ile Ala  Ala Thr Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr Tyr Ile Asn Leu  Lys Thr Gln Lys Leu  His Glu Tyr 
    1145                 1150                 1155             


Tyr Ile  Glu Asn Tyr Asn Thr  Ala Leu Gly Tyr Lys  Lys Tyr Ser 
    1160                 1165                 1170             


Lys Glu  Met Glu Phe Leu Arg  Ser Leu Ala Tyr Arg  Ser Arg Arg 
    1175                 1180                 1185             


Val Lys  Ile Lys Ser Ile Asp  Asp Val Lys Gln Val  Leu Asp Lys 
    1190                 1195                 1200             


Asp Ser  Asn Phe Ile Ile Gly  Lys Ile Thr Leu Pro  Phe Lys Lys 
    1205                 1210                 1215             


Glu Trp  Gln Arg Leu Tyr Arg  Glu Trp Gln Asn Thr  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asp  Tyr Glu Phe Leu Lys  Ser Phe Phe Asn Val  Lys Ser Ile 
    1235                 1240                 1245             


Thr Lys  Leu His Lys Lys Val  Arg Lys Asp Phe Ser  Leu Pro Ile 
    1250                 1255                 1260             


Ser Thr  Asn His Gly Lys Phe  Leu Val Lys Arg Lys  Thr Trp Asp 
    1265                 1270                 1275             


Asn Asn  Phe Ile Tyr Gln Ile  Leu Asn Asp Ser Asp  Ser Arg Ala 
    1280                 1285                 1290             


Asp Gly  Thr Lys Pro Phe Ile  Pro Ala Phe Asp Ile  Ser Lys Asn 
    1295                 1300                 1305             


Glu Ile  Val Glu Ala Ile Ile  Asp Ser Phe Thr Ser  Lys Asn Ile 
    1310                 1315                 1320             


Phe Trp  Leu Pro Lys Asn Ile  Glu Leu Gln Lys Val  Asp Asn Lys 
    1325                 1330                 1335             


Asn Ile  Phe Ala Ile Asp Thr  Ser Lys Trp Phe Glu  Val Glu Thr 
    1340                 1345                 1350             


Pro Ser  Asp Leu Arg Asp Ile  Gly Ile Ala Thr Ile  Gln Tyr Lys 
    1355                 1360                 1365             


Ile Asp  Asn Asn Ser Gln Pro  Lys Val Arg Val Lys  Leu Asp Tyr 
    1370                 1375                 1380             


Val Ile  Asp Asp Asp Ser Lys  Ile Asn Tyr Phe Met  Asn His Ser 
    1385                 1390                 1395             


Leu Leu  Lys Ser Arg Tyr Pro  Asp Lys Val Leu Glu  Ile Leu Lys 
    1400                 1405                 1410             


Gln Ser  Thr Ile Ile Glu Phe  Glu Ser Ser Gly Phe  Asn Lys Thr 
    1415                 1420                 1425             


Ile Lys  Glu Met Leu Gly Met  Lys Leu Ala Gly Ile  Tyr Asn Glu 
    1430                 1435                 1440             


Thr Ser  Asn Asn 
    1445         


<210>  100
<211>  2025
<212>  PRT
<213>  synthetic

<400>  100

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Arg  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  101
<211>  2025
<212>  PRT
<213>  synthetic

<400>  101

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn His  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  102
<211>  2025
<212>  PRT
<213>  synthetic

<400>  102

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Arg  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn His  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  103
<211>  2025
<212>  PRT
<213>  synthetic

<400>  103

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Thr Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  104
<211>  2025
<212>  PRT
<213>  synthetic

<400>  104

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Tyr  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  105
<211>  2025
<212>  PRT
<213>  synthetic

<400>  105

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Arg 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  106
<211>  2025
<212>  PRT
<213>  synthetic

<400>  106

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Lys 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  107
<211>  2025
<212>  PRT
<213>  synthetic

<400>  107

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Arg Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  108
<211>  2025
<212>  PRT
<213>  synthetic

<400>  108

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Tyr Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  109
<211>  2025
<212>  PRT
<213>  synthetic

<400>  109

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Tyr Glu Phe Glu Leu 
            580                 585                 590         


Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln Lys 
        595                 600                 605             


Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr Tyr 
    610                 615                 620                 


His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala Thr 
625                 630                 635                 640 


Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp Ile 
                645                 650                 655     


Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu Lys 
            660                 665                 670         


Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His His 
        675                 680                 685             


Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly Gly 
    690                 695                 700                 


Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp Glu 
705                 710                 715                 720 


Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu His 
                725                 730                 735     


Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu Ile 
            740                 745                 750         


Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe Asn 
        755                 760                 765             


Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe Thr 
    770                 775                 780                 


Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val Lys 
785                 790                 795                 800 


Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu Cys 
                805                 810                 815     


Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe Leu 
            820                 825                 830         


Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn 
        835                 840                 845             


Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe 
    850                 855                 860                 


Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys 
865                 870                 875                 880 


Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp Leu 
                885                 890                 895     


Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr Lys 
            900                 905                 910         


Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu 
        915                 920                 925             


Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp 
    930                 935                 940                 


Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys Gln 
945                 950                 955                 960 


Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu Asp 
                965                 970                 975     


Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His 
            980                 985                 990         


Thr Asn Gly Ile Phe Glu Gln Gly  Thr Phe Leu His Leu  Val Cys Lys 
        995                 1000                 1005             


Tyr Tyr  Lys Gln Arg Gln Arg  Ala Arg Asp Ser Arg  Leu Tyr Ile 
    1010                 1015                 1020             


Met Pro  Glu Tyr Arg Tyr Asp  Lys Lys Leu His Lys  Tyr Asn Asn 
    1025                 1030                 1035             


Thr Gly  Arg Phe Asp Asp Asp  Asn Gln Leu Leu Thr  Tyr Cys Asn 
    1040                 1045                 1050             


His Lys  Pro Arg Gln Lys Arg  Tyr Gln Leu Leu Asn  Asp Leu Ala 
    1055                 1060                 1065             


Gly Val  Leu Gln Val Ser Pro  Asn Phe Leu Lys Asp  Lys Ile Gly 
    1070                 1075                 1080             


Ser Asp  Asp Asp Leu Phe Ile  Ser Lys Trp Leu Val  Glu His Ile 
    1085                 1090                 1095             


Arg Gly  Phe Lys Lys Ala Cys  Glu Asp Ser Leu Lys  Ile Gln Lys 
    1100                 1105                 1110             


Asp Asn  Arg Gly Leu Leu Asn  His Lys Ile Asn Ile  Ala Arg Asn 
    1115                 1120                 1125             


Thr Lys  Gly Lys Cys Glu Lys  Glu Ile Phe Asn Leu  Ile Cys Lys 
    1130                 1135                 1140             


Ile Glu  Gly Ser Glu Asp Lys  Lys Gly Asn Tyr Lys  His Gly Leu 
    1145                 1150                 1155             


Ala Tyr  Glu Leu Gly Val Leu  Leu Phe Gly Glu Pro  Asn Glu Ala 
    1160                 1165                 1170             


Ser Lys  Pro Glu Phe Asp Arg  Lys Ile Lys Lys Phe  Asn Ser Ile 
    1175                 1180                 1185             


Tyr Ser  Phe Ala Gln Ile Gln  Gln Ile Ala Phe Ala  Glu Arg Lys 
    1190                 1195                 1200             


Gly Asn  Ala Asn Thr Cys Ala  Val Cys Ser Ala Asp  Asn Ala His 
    1205                 1210                 1215             


Arg Met  Gln Gln Ile Lys Ile  Thr Glu Pro Val Glu  Asp Asn Lys 
    1220                 1225                 1230             


Asp Lys  Ile Ile Leu Ser Ala  Lys Ala Gln Arg Leu  Pro Ala Ile 
    1235                 1240                 1245             


Pro Thr  Arg Ile Val Asp Gly  Ala Val Lys Lys Met  Ala Thr Ile 
    1250                 1255                 1260             


Leu Ala  Lys Asn Ile Val Asp  Asp Asn Trp Gln Asn  Ile Lys Gln 
    1265                 1270                 1275             


Val Leu  Ser Ala Lys His Gln  Leu His Ile Pro Ile  Ile Thr Glu 
    1280                 1285                 1290             


Ser Asn  Ala Phe Glu Phe Glu  Pro Ala Leu Ala Asp  Val Lys Gly 
    1295                 1300                 1305             


Lys Ser  Leu Lys Asp Arg Arg  Lys Lys Ala Leu Glu  Arg Ile Ser 
    1310                 1315                 1320             


Pro Glu  Asn Ile Phe Lys Asp  Lys Asn Asn Arg Ile  Lys Glu Phe 
    1325                 1330                 1335             


Ala Lys  Gly Ile Ser Ala Tyr  Ser Gly Ala Asn Leu  Thr Asp Gly 
    1340                 1345                 1350             


Asp Phe  Asp Gly Ala Lys Glu  Glu Leu Asp His Ile  Ile Pro Arg 
    1355                 1360                 1365             


Ser His  Lys Lys Tyr Gly Thr  Leu Asn Asp Glu Ala  Asn Leu Ile 
    1370                 1375                 1380             


Cys Val  Thr Arg Gly Asp Asn  Lys Asn Lys Gly Asn  Arg Ile Phe 
    1385                 1390                 1395             


Cys Leu  Arg Asp Leu Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu 
    1400                 1405                 1410             


Thr Thr  Asp Asp Leu Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile 
    1415                 1420                 1425             


Trp Asp  Ala Asn Lys Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser 
    1430                 1435                 1440             


Phe Ile  Asn Leu Thr Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala 
    1445                 1450                 1455             


Leu Phe  Leu Ala Asp Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg 
    1460                 1465                 1470             


Ala Ile  Asn Asn Arg Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg 
    1475                 1480                 1485             


Tyr Phe  Ala Glu Val Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys 
    1490                 1495                 1500             


Lys Glu  Asn Leu Asn Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly 
    1505                 1510                 1515             


Ile Pro  Thr Ile Gly Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln 
    1520                 1525                 1530             


Leu Tyr  Glu Lys Val Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly 
    1535                 1540                 1545             


Asp Lys  Pro Gln Ala Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu 
    1550                 1555                 1560             


Ala Phe  Cys Ile Ala Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile 
    1565                 1570                 1575             


Gly Leu  Glu Ile Asp Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys 
    1580                 1585                 1590             


Asn Thr  Gly Glu Val Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys 
    1595                 1600                 1605             


Ile Thr  Asp Asn Glu Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys 
    1610                 1615                 1620             


Ala Ile  Glu Gly Phe Asn Thr  His Arg Gln Met Thr  Arg Asp Gly 
    1625                 1630                 1635             


Ile Tyr  Ala Glu Asn Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu 
    1640                 1645                 1650             


Asn Glu  Val Arg Lys Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile 
    1655                 1660                 1665             


Lys Ile  Phe Lys Gly Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn 
    1670                 1675                 1680             


Leu Val  Tyr Cys Leu Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp 
    1685                 1690                 1695             


Ile Gln  Ile Ser Thr Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr 
    1700                 1705                 1710             


Asn Asn  Ile Ala Ala Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys 
    1715                 1720                 1725             


Thr Gln  Lys Leu His Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala 
    1730                 1735                 1740             


Leu Gly  Tyr Lys Lys Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser 
    1745                 1750                 1755             


Leu Ala  Tyr Arg Ser Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp 
    1760                 1765                 1770             


Val Lys  Gln Val Leu Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys 
    1775                 1780                 1785             


Ile Thr  Leu Pro Phe Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu 
    1790                 1795                 1800             


Trp Gln  Asn Thr Thr Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser 
    1805                 1810                 1815             


Phe Phe  Asn Val Lys Ser Ile  Thr Lys Leu His Lys  Lys Val Arg 
    1820                 1825                 1830             


Lys Asp  Phe Ser Leu Pro Ile  Ser Thr Asn Glu Gly  Lys Val Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  110
<211>  2025
<212>  PRT
<213>  synthetic

<400>  110

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Thr Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  111
<211>  2025
<212>  PRT
<213>  synthetic

<400>  111

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Val Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  112
<211>  2025
<212>  PRT
<213>  synthetic

<400>  112

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg His Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  113
<211>  2025
<212>  PRT
<213>  synthetic

<400>  113

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Arg Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  114
<211>  2025
<212>  PRT
<213>  synthetic

<400>  114

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


His Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  115
<211>  2025
<212>  PRT
<213>  synthetic

<400>  115

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Arg  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn His  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Thr Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  116
<211>  2025
<212>  PRT
<213>  synthetic

<400>  116

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Tyr Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  117
<211>  2025
<212>  PRT
<213>  synthetic

<400>  117

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Phe Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  118
<211>  2025
<212>  PRT
<213>  synthetic

<400>  118

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp His  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  119
<211>  2025
<212>  PRT
<213>  synthetic

<400>  119

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Arg Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  120
<211>  2025
<212>  PRT
<213>  synthetic

<400>  120

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Arg Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  121
<211>  2025
<212>  PRT
<213>  synthetic

<400>  121

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Val  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  122
<211>  2025
<212>  PRT
<213>  synthetic

<400>  122

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Ser  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  123
<211>  2025
<212>  PRT
<213>  synthetic

<400>  123

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Asn  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  124
<211>  2025
<212>  PRT
<213>  synthetic

<400>  124

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Phe Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  125
<211>  2025
<212>  PRT
<213>  synthetic

<400>  125

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Arg Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  126
<211>  2026
<212>  PRT
<213>  synthetic

<400>  126

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Arg Ser Asn  Phe Ile Ile 
    1775                 1780                 1785             


Gly Lys  Ile Thr Leu Pro Phe  Lys Lys Glu Trp Gln  Arg Leu Tyr 
    1790                 1795                 1800             


Arg Glu  Trp Gln Asn Thr Thr  Ile Lys Asp Asp Tyr  Glu Phe Leu 
    1805                 1810                 1815             


Lys Ser  Phe Phe Asn Val Lys  Ser Ile Thr Lys Leu  His Lys Lys 
    1820                 1825                 1830             


Val Arg  Lys Asp Phe Ser Leu  Pro Ile Ser Thr Asn  Glu Gly Lys 
    1835                 1840                 1845             


Phe Leu  Val Lys Arg Lys Thr  Trp Asp Asn Asn Phe  Ile Tyr Gln 
    1850                 1855                 1860             


Ile Leu  Asn Asp Ser Asp Ser  Arg Ala Asp Gly Thr  Lys Pro Phe 
    1865                 1870                 1875             


Ile Pro  Ala Phe Asp Ile Ser  Lys Asn Glu Ile Val  Glu Ala Ile 
    1880                 1885                 1890             


Ile Asp  Ser Phe Thr Ser Lys  Asn Ile Phe Trp Leu  Pro Lys Asn 
    1895                 1900                 1905             


Ile Glu  Leu Gln Lys Val Asp  Asn Lys Asn Ile Phe  Ala Ile Asp 
    1910                 1915                 1920             


Thr Ser  Lys Trp Phe Glu Val  Glu Thr Pro Ser Asp  Leu Arg Asp 
    1925                 1930                 1935             


Ile Gly  Ile Ala Thr Ile Gln  Tyr Lys Ile Asp Asn  Asn Ser Arg 
    1940                 1945                 1950             


Pro Lys  Val Arg Val Lys Leu  Asp Tyr Val Ile Asp  Asp Asp Ser 
    1955                 1960                 1965             


Lys Ile  Asn Tyr Phe Met Asn  His Ser Leu Leu Lys  Ser Arg Tyr 
    1970                 1975                 1980             


Pro Asp  Lys Val Leu Glu Ile  Leu Lys Gln Ser Thr  Ile Ile Glu 
    1985                 1990                 1995             


Phe Glu  Ser Ser Gly Phe Asn  Lys Thr Ile Lys Glu  Met Leu Gly 
    2000                 2005                 2010             


Met Lys  Leu Ala Gly Ile Tyr  Asn Glu Thr Ser Asn  Asn 
    2015                 2020                 2025     


<210>  127
<211>  2025
<212>  PRT
<213>  synthetic

<400>  127

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg His Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


His Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  128
<211>  2025
<212>  PRT
<213>  synthetic

<400>  128

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Lys 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Tyr Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  129
<211>  2025
<212>  PRT
<213>  synthetic

<400>  129

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Thr Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Arg  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn His  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  130
<211>  2025
<212>  PRT
<213>  synthetic

<400>  130

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Arg  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Lys 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn His  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  131
<211>  2025
<212>  PRT
<213>  synthetic

<400>  131

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Arg  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Tyr His  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  132
<211>  2025
<212>  PRT
<213>  synthetic

<400>  132

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Arg  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


His Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  133
<211>  2025
<212>  PRT
<213>  synthetic

<400>  133

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Arg  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Lys 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  134
<211>  2025
<212>  PRT
<213>  synthetic

<400>  134

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Arg  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Arg Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  135
<211>  2025
<212>  PRT
<213>  synthetic

<400>  135

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Arg  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Tyr Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  136
<211>  2025
<212>  PRT
<213>  synthetic

<400>  136

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Arg  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Phe Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  137
<211>  2025
<212>  PRT
<213>  synthetic

<400>  137

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Arg  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Arg Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  138
<211>  2025
<212>  PRT
<213>  synthetic

<400>  138

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Thr Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Arg  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  139
<211>  2025
<212>  PRT
<213>  synthetic

<400>  139

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Arg  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Gln Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  140
<211>  2025
<212>  PRT
<213>  synthetic

<400>  140

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Lys 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


His Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  141
<211>  2025
<212>  PRT
<213>  synthetic

<400>  141

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Arg Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


His Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  142
<211>  2025
<212>  PRT
<213>  synthetic

<400>  142

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Tyr Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


His Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  143
<211>  2025
<212>  PRT
<213>  synthetic

<400>  143

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Phe Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


His Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  144
<211>  2025
<212>  PRT
<213>  synthetic

<400>  144

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Arg Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


His Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  145
<211>  2025
<212>  PRT
<213>  synthetic

<400>  145

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Thr Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Arg Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


His Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  146
<211>  2025
<212>  PRT
<213>  synthetic

<400>  146

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Gln Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


His Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  147
<211>  2024
<212>  PRT
<213>  synthetic

<400>  147

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Glu  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn Glu  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Gln Lys 
    1940                 1945                 1950             


Val Arg  Val Lys Leu Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile 
    1955                 1960                 1965             


Asn Tyr  Phe Met Asn His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp 
    1970                 1975                 1980             


Lys Val  Leu Glu Ile Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu 
    1985                 1990                 1995             


Ser Ser  Gly Phe Asn Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys 
    2000                 2005                 2010             


Leu Ala  Gly Ile Tyr Asn Glu  Thr Ser Asn Asn 
    2015                 2020                 


<210>  148
<211>  2025
<212>  PRT
<213>  synthetic

<400>  148

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Ser Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Trp 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Arg 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asn Phe Lys 
385                 390                 395                 400 


Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
                405                 410                 415     


Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg Leu Asp Asn Lys 
            420                 425                 430         


Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr Thr Leu Leu Met 
        435                 440                 445             


Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
    450                 455                 460                 


Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr Glu Gln Leu Asn 
465                 470                 475                 480 


Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser Phe Leu Phe Asn 
                485                 490                 495     


Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser Pro Glu Tyr Leu 
            500                 505                 510         


Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met Asp Ile Phe Asp 
        515                 520                 525             


Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys Leu Met Gln Lys 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp Ile Lys Asp Asp 
                565                 570                 575     


Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser Tyr Glu Phe Glu 
            580                 585                 590         


Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser Leu Lys Thr Gln 
        595                 600                 605             


Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys Glu Leu Ser Tyr 
    610                 615                 620                 


Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu Lys Arg His Ala 
625                 630                 635                 640 


Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr Asp Asp Leu Asp 
                645                 650                 655     


Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp Lys Asn Glu Glu 
            660                 665                 670         


Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln Ala His Leu His 
        675                 680                 685             


His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met Ala Ser Gly 
    690                 695                 700                 


Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn Val Leu Asp 
705                 710                 715                 720 


Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys Glu Asn Leu 
                725                 730                 735     


His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu Val Asn Leu 
            740                 745                 750         


Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg Lys Tyr Phe 
        755                 760                 765             


Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp Glu Gln Lys Phe 
    770                 775                 780                 


Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp Arg Val Gly Val 
785                 790                 795                 800 


Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr Lys Asp Leu 
                805                 810                 815     


Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly Leu Val Asp Phe 
            820                 825                 830         


Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn 
        835                 840                 845             


Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys 
    850                 855                 860                 


Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu 
865                 870                 875                 880 


Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser Phe Glu Thr Asp 
                885                 890                 895     


Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr Phe Val Glu Tyr 
            900                 905                 910         


Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp 
        915                 920                 925             


Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser 
    930                 935                 940                 


Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala Lys Lys Leu Lys 
945                 950                 955                 960 


Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser Ser Lys Lys Leu 
                965                 970                 975     


Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln 
            980                 985                 990         


His Thr Asn Gly Ile Phe Glu Gln  Gly Thr Phe Leu His  Leu Val Cys 
        995                 1000                 1005             


Lys Tyr  Tyr Lys Gln Arg Gln  Arg Ala Arg Asp Ser  Arg Leu Tyr 
    1010                 1015                 1020             


Ile Met  Pro Glu Tyr Arg Tyr  Asp Lys Lys Leu His  Lys Tyr Asn 
    1025                 1030                 1035             


Asn Thr  Gly Arg Phe Asp Asp  Asp Asn Gln Leu Leu  Thr Tyr Cys 
    1040                 1045                 1050             


Asn His  Lys Pro Arg Gln Lys  Arg Tyr Gln Leu Leu  Asn Asp Leu 
    1055                 1060                 1065             


Ala Gly  Val Leu Gln Val Ser  Pro Asn Phe Leu Lys  Asp Lys Ile 
    1070                 1075                 1080             


Gly Ser  Asp Asp Asp Leu Phe  Ile Ser Lys Trp Leu  Val Glu His 
    1085                 1090                 1095             


Ile Arg  Gly Phe Lys Lys Ala  Cys Glu Asp Ser Leu  Lys Ile Gln 
    1100                 1105                 1110             


Lys Asp  Asn Arg Gly Leu Leu  Asn His Lys Ile Asn  Ile Ala Arg 
    1115                 1120                 1125             


Asn Thr  Lys Gly Lys Cys Glu  Lys Glu Ile Phe Asn  Leu Ile Cys 
    1130                 1135                 1140             


Lys Ile  Glu Gly Ser Glu Asp  Lys Lys Gly Asn Tyr  Lys His Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Glu Leu Gly Val  Leu Leu Phe Gly Glu  Pro Asn Glu 
    1160                 1165                 1170             


Ala Ser  Lys Pro Glu Phe Asp  Arg Lys Ile Lys Lys  Phe Asn Ser 
    1175                 1180                 1185             


Ile Tyr  Ser Phe Ala Gln Ile  Gln Gln Ile Ala Phe  Ala Glu Arg 
    1190                 1195                 1200             


Lys Gly  Asn Ala Asn Thr Cys  Ala Val Cys Ser Ala  Asp Asn Ala 
    1205                 1210                 1215             


His Arg  Met Gln Gln Ile Lys  Ile Thr Glu Pro Val  Glu Asp Asn 
    1220                 1225                 1230             


Lys Asp  Lys Ile Ile Leu Ser  Ala Lys Ala Gln Arg  Leu Pro Ala 
    1235                 1240                 1245             


Ile Pro  Thr Arg Ile Val Asp  Gly Ala Val Lys Lys  Met Ala Thr 
    1250                 1255                 1260             


Ile Leu  Ala Lys Asn Ile Val  Asp Asp Asn Trp Gln  Asn Ile Lys 
    1265                 1270                 1275             


Gln Val  Leu Ser Ala Lys His  Gln Leu His Ile Pro  Ile Ile Thr 
    1280                 1285                 1290             


Glu Ser  Asn Ala Phe Glu Phe  Glu Pro Ala Leu Ala  Asp Val Lys 
    1295                 1300                 1305             


Gly Lys  Ser Leu Lys Asp Arg  Arg Lys Lys Ala Leu  Glu Arg Ile 
    1310                 1315                 1320             


Ser Pro  Glu Asn Ile Phe Lys  Asp Lys Asn Asn Arg  Ile Lys Glu 
    1325                 1330                 1335             


Phe Ala  Lys Gly Ile Ser Ala  Tyr Ser Gly Ala Asn  Leu Thr Asp 
    1340                 1345                 1350             


Gly Asp  Phe Asp Gly Ala Lys  Glu Glu Leu Asp His  Ile Ile Pro 
    1355                 1360                 1365             


Arg Ser  His Lys Lys Tyr Gly  Thr Leu Asn Asp Glu  Ala Asn Leu 
    1370                 1375                 1380             


Ile Cys  Val Thr Arg Gly Asp  Asn Lys Asn Lys Gly  Asn Arg Ile 
    1385                 1390                 1395             


Phe Cys  Leu Arg Asp Leu Ala  Asp Asn Tyr Lys Leu  Lys Gln Phe 
    1400                 1405                 1410             


Glu Thr  Thr Asp Asp Leu Glu  Ile Glu Lys Lys Ile  Ala Asp Thr 
    1415                 1420                 1425             


Ile Trp  Asp Ala Asn Lys Lys  Asp Phe Lys Phe Gly  Asn Tyr Arg 
    1430                 1435                 1440             


Ser Phe  Ile Asn Leu Thr Pro  Gln Glu Gln Lys Ala  Phe Arg His 
    1445                 1450                 1455             


Ala Leu  Phe Leu Ala Asp Glu  Asn Pro Ile Lys Gln  Ala Val Ile 
    1460                 1465                 1470             


Arg Ala  Ile Asn Asn Arg Asn  Arg Thr Phe Val Asn  Gly Thr Gln 
    1475                 1480                 1485             


Arg Tyr  Phe Ala Glu Val Leu  Ala Asn Asn Ile Tyr  Leu Arg Ala 
    1490                 1495                 1500             


Lys Lys  Glu Asn Leu Asn Thr  Asp Lys Ile Ser Phe  Asp Tyr Phe 
    1505                 1510                 1515             


Gly Ile  Pro Thr Ile Gly Asn  Gly Arg Gly Ile Ala  Glu Ile Arg 
    1520                 1525                 1530             


Gln Leu  Tyr Glu Lys Val Asp  Ser Asp Ile Gln Ala  Tyr Ala Lys 
    1535                 1540                 1545             


Gly Asp  Lys Pro Gln Ala Ser  Tyr Ser His Leu Ile  Asp Ala Met 
    1550                 1555                 1560             


Leu Ala  Phe Cys Ile Ala Ala  Asp Glu His Arg Asn  Asp Gly Ser 
    1565                 1570                 1575             


Ile Gly  Leu Glu Ile Asp Lys  Asn Tyr Ser Leu Tyr  Pro Leu Asp 
    1580                 1585                 1590             


Lys Asn  Thr Gly Glu Val Phe  Thr Lys Asp Ile Phe  Ser Gln Ile 
    1595                 1600                 1605             


Lys Ile  Thr Asp Asn Glu Phe  Ser Asp Lys Lys Leu  Val Arg Lys 
    1610                 1615                 1620             


Lys Ala  Ile Glu Gly Phe Asn  Thr His Arg Gln Met  Thr Arg Asp 
    1625                 1630                 1635             


Gly Ile  Tyr Ala Glu Asn Tyr  Leu Pro Ile Leu Ile  His Lys Glu 
    1640                 1645                 1650             


Leu Asn  Glu Val Arg Lys Gly  Tyr Thr Trp Lys Asn  Ser Glu Glu 
    1655                 1660                 1665             


Ile Lys  Ile Phe Lys Gly Lys  Lys Tyr Asp Ile Gln  Gln Leu Asn 
    1670                 1675                 1680             


Asn Leu  Val Tyr Cys Leu Lys  Phe Val Asp Lys Pro  Ile Ser Ile 
    1685                 1690                 1695             


Asp Ile  Gln Ile Ser Thr Leu  Glu Glu Leu Arg Asn  Ile Leu Thr 
    1700                 1705                 1710             


Thr Asn  Asn Ile Ala Ala Thr  Ala Glu Tyr Tyr Tyr  Ile Asn Leu 
    1715                 1720                 1725             


Lys Thr  Gln Lys Leu His Glu  Tyr Tyr Ile Glu Asn  Tyr Asn Thr 
    1730                 1735                 1740             


Ala Leu  Gly Tyr Lys Lys Tyr  Ser Lys Glu Met Glu  Phe Leu Arg 
    1745                 1750                 1755             


Ser Leu  Ala Tyr Arg Ser Arg  Arg Val Lys Ile Lys  Ser Ile Asp 
    1760                 1765                 1770             


Asp Val  Lys Gln Val Leu Asp  Lys Asp Ser Asn Phe  Ile Ile Gly 
    1775                 1780                 1785             


Lys Ile  Thr Leu Pro Phe Lys  Lys Glu Trp Gln Arg  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Trp  Gln Asn Thr Thr Ile  Lys Asp Asp Tyr Glu  Phe Leu Lys 
    1805                 1810                 1815             


Ser Phe  Phe Asn Val Lys Ser  Ile Thr Lys Leu His  Lys Lys Val 
    1820                 1825                 1830             


Arg Lys  Asp Phe Ser Leu Pro  Ile Ser Thr Asn His  Gly Lys Phe 
    1835                 1840                 1845             


Leu Val  Lys Arg Lys Thr Trp  Asp Asn Asn Phe Ile  Tyr Gln Ile 
    1850                 1855                 1860             


Leu Asn  Asp Ser Asp Ser Arg  Ala Asp Gly Thr Lys  Pro Phe Ile 
    1865                 1870                 1875             


Pro Ala  Phe Asp Ile Ser Lys  Asn Glu Ile Val Glu  Ala Ile Ile 
    1880                 1885                 1890             


Asp Ser  Phe Thr Ser Lys Asn  Ile Phe Trp Leu Pro  Lys Asn Ile 
    1895                 1900                 1905             


Glu Leu  Gln Lys Val Asp Asn  Lys Asn Ile Phe Ala  Ile Asp Thr 
    1910                 1915                 1920             


Ser Lys  Trp Phe Glu Val Glu  Thr Pro Ser Asp Leu  Arg Asp Ile 
    1925                 1930                 1935             


Gly Ile  Ala Thr Ile Gln Tyr  Lys Ile Asp Asn Asn  Ser Gln Pro 
    1940                 1945                 1950             


Lys Val  Arg Val Lys Leu Asp  Tyr Val Ile Asp Asp  Asp Ser Lys 
    1955                 1960                 1965             


Ile Asn  Tyr Phe Met Asn His  Ser Leu Leu Lys Ser  Arg Tyr Pro 
    1970                 1975                 1980             


Asp Lys  Val Leu Glu Ile Leu  Lys Gln Ser Thr Ile  Ile Glu Phe 
    1985                 1990                 1995             


Glu Ser  Ser Gly Phe Asn Lys  Thr Ile Lys Glu Met  Leu Gly Met 
    2000                 2005                 2010             


Lys Leu  Ala Gly Ile Tyr Asn  Glu Thr Ser Asn Asn  
    2015                 2020                 2025 


<210>  149
<211>  2074
<212>  PRT
<213>  synthetic

<400>  149

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Arg Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  150
<211>  2074
<212>  PRT
<213>  synthetic

<400>  150

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn His Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  151
<211>  2074
<212>  PRT
<213>  syntehtic

<400>  151

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Arg Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn His Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  152
<211>  2074
<212>  PRT
<213>  synthetic

<400>  152

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Thr Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  153
<211>  2074
<212>  PRT
<213>  synthetic

<400>  153

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Tyr Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  154
<211>  2074
<212>  PRT
<213>  synthetic

<400>  154

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Arg Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  155
<211>  2074
<212>  PRT
<213>  synthetic

<400>  155

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Lys Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  156
<211>  2074
<212>  PRT
<213>  synthetic

<400>  156

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Arg Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  157
<211>  2074
<212>  PRT
<213>  synthetic

<400>  157

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Tyr Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  158
<211>  2075
<212>  PRT
<213>  synthetic

<400>  158

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Val Phe Leu 
    1700                 1705                 1710             


Val Lys  Arg Lys Thr Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu 
    1715                 1720                 1725             


Asn Asp  Ser Asp Ser Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro 
    1730                 1735                 1740             


Ala Phe  Asp Ile Ser Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp 
    1745                 1750                 1755             


Ser Phe  Thr Ser Lys Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu 
    1760                 1765                 1770             


Leu Gln  Lys Val Asp Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser 
    1775                 1780                 1785             


Lys Trp  Phe Glu Val Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly 
    1790                 1795                 1800             


Ile Ala  Thr Ile Gln Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys 
    1805                 1810                 1815             


Val Arg  Val Lys Leu Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile 
    1820                 1825                 1830             


Asn Tyr  Phe Met Asn His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp 
    1835                 1840                 1845             


Lys Val  Leu Glu Ile Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu 
    1850                 1855                 1860             


Ser Ser  Gly Phe Asn Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys 
    1865                 1870                 1875             


Leu Ala  Gly Ile Tyr Asn Glu  Thr Ser Asn Asn Ser  Gly Gly Ser 
    1880                 1885                 1890             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1895                 1900                 1905             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1910                 1915                 1920             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1925                 1930                 1935             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1940                 1945                 1950             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1955                 1960                 1965             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1970                 1975                 1980             


Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Thr Asn Leu  Ser Asp Ile 
    1985                 1990                 1995             


Ile Glu  Lys Glu Thr Gly Lys  Gln Leu Val Ile Gln  Glu Ser Ile 
    2000                 2005                 2010             


Leu Met  Leu Pro Glu Glu Val  Glu Glu Val Ile Gly  Asn Lys Pro 
    2015                 2020                 2025             


Glu Ser  Asp Ile Leu Val His  Thr Ala Tyr Asp Glu  Ser Thr Asp 
    2030                 2035                 2040             


Glu Asn  Val Met Leu Leu Thr  Ser Asp Ala Pro Glu  Tyr Lys Pro 
    2045                 2050                 2055             


Trp Ala  Leu Val Ile Gln Asp  Ser Asn Gly Glu Asn  Lys Ile Lys 
    2060                 2065                 2070             


Met Leu  
    2075 


<210>  159
<211>  2074
<212>  PRT
<213>  synthetic

<400>  159

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Thr Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  160
<211>  2074
<212>  PRT
<213>  synthetic

<400>  160

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Val Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  161
<211>  2074
<212>  PRT
<213>  synthetic

<400>  161

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg His  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  162
<211>  2074
<212>  PRT
<213>  synthetic

<400>  162

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Arg  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  163
<211>  2074
<212>  PRT
<213>  synthetic

<400>  163

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe His Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  164
<211>  2074
<212>  PRT
<213>  synthetic

<400>  164

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Arg Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn His Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Thr  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  165
<211>  2074
<212>  PRT
<213>  synthetic

<400>  165

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Tyr Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  166
<211>  2074
<212>  PRT
<213>  synthetic

<400>  166

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Phe Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  167
<211>  2074
<212>  PRT
<213>  synthetic

<400>  167

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp His 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  168
<211>  2074
<212>  PRT
<213>  synthetic

<400>  168

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Arg Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  169
<211>  2074
<212>  PRT
<213>  synthetic

<400>  169

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Arg Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  170
<211>  2074
<212>  PRT
<213>  synthetic

<400>  170

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Val Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  171
<211>  2074
<212>  PRT
<213>  synthetic

<400>  171

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Ser Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  172
<211>  2074
<212>  PRT
<213>  synthetic

<400>  172

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Asn Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  173
<211>  2074
<212>  PRT
<213>  synthetic

<400>  173

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Phe Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  174
<211>  2074
<212>  PRT
<213>  synthetic

<400>  174

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Arg Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  175
<211>  2075
<212>  PRT
<213>  synthetic

<400>  175

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Arg Ser Asn Phe Ile  Ile Gly Lys 
    1640                 1645                 1650             


Ile Thr  Leu Pro Phe Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu 
    1655                 1660                 1665             


Trp Gln  Asn Thr Thr Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser 
    1670                 1675                 1680             


Phe Phe  Asn Val Lys Ser Ile  Thr Lys Leu His Lys  Lys Val Arg 
    1685                 1690                 1695             


Lys Asp  Phe Ser Leu Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu 
    1700                 1705                 1710             


Val Lys  Arg Lys Thr Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu 
    1715                 1720                 1725             


Asn Asp  Ser Asp Ser Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro 
    1730                 1735                 1740             


Ala Phe  Asp Ile Ser Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp 
    1745                 1750                 1755             


Ser Phe  Thr Ser Lys Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu 
    1760                 1765                 1770             


Leu Gln  Lys Val Asp Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser 
    1775                 1780                 1785             


Lys Trp  Phe Glu Val Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly 
    1790                 1795                 1800             


Ile Ala  Thr Ile Gln Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys 
    1805                 1810                 1815             


Val Arg  Val Lys Leu Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile 
    1820                 1825                 1830             


Asn Tyr  Phe Met Asn His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp 
    1835                 1840                 1845             


Lys Val  Leu Glu Ile Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu 
    1850                 1855                 1860             


Ser Ser  Gly Phe Asn Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys 
    1865                 1870                 1875             


Leu Ala  Gly Ile Tyr Asn Glu  Thr Ser Asn Asn Ser  Gly Gly Ser 
    1880                 1885                 1890             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1895                 1900                 1905             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1910                 1915                 1920             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1925                 1930                 1935             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1940                 1945                 1950             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1955                 1960                 1965             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1970                 1975                 1980             


Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Thr Asn Leu  Ser Asp Ile 
    1985                 1990                 1995             


Ile Glu  Lys Glu Thr Gly Lys  Gln Leu Val Ile Gln  Glu Ser Ile 
    2000                 2005                 2010             


Leu Met  Leu Pro Glu Glu Val  Glu Glu Val Ile Gly  Asn Lys Pro 
    2015                 2020                 2025             


Glu Ser  Asp Ile Leu Val His  Thr Ala Tyr Asp Glu  Ser Thr Asp 
    2030                 2035                 2040             


Glu Asn  Val Met Leu Leu Thr  Ser Asp Ala Pro Glu  Tyr Lys Pro 
    2045                 2050                 2055             


Trp Ala  Leu Val Ile Gln Asp  Ser Asn Gly Glu Asn  Lys Ile Lys 
    2060                 2065                 2070             


Met Leu  
    2075 


<210>  176
<211>  2074
<212>  PRT
<213>  synthetic

<400>  176

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg His  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe His Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  177
<211>  2074
<212>  PRT
<213>  synthetic

<400>  177

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Lys Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Tyr Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  178
<211>  2074
<212>  PRT
<213>  synthetic

<400>  178

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Thr Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Arg Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn His Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  179
<211>  2074
<212>  PRT
<213>  synthetic

<400>  179

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Arg Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Lys Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn His Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  180
<211>  2074
<212>  PRT
<213>  synthetic

<400>  180

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Arg Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Tyr His Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  181
<211>  2074
<212>  PRT
<213>  synthetic

<400>  181

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Arg Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe His Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  182
<211>  2074
<212>  PRT
<213>  synthetic

<400>  182

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Arg Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Lys Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  183
<211>  2074
<212>  PRT
<213>  synthetic

<400>  183

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Arg Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Arg Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  184
<211>  2074
<212>  PRT
<213>  synthetic

<400>  184

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Arg Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Tyr Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  185
<211>  2074
<212>  PRT
<213>  synthetic

<400>  185

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Arg Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Phe Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  186
<211>  2074
<212>  PRT
<213>  synthetic

<400>  186

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Arg Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Arg Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  187
<211>  2074
<212>  PRT
<213>  synthetic

<400>  187

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Thr Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Arg Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  188
<211>  2074
<212>  PRT
<213>  synthetic

<400>  188

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Arg Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Gln  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  189
<211>  2074
<212>  PRT
<213>  synthetic

<400>  189

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Lys Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe His Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  190
<211>  2074
<212>  PRT
<213>  synthetic

<400>  190

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Arg Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe His Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  191
<211>  2074
<212>  PRT
<213>  synthetic

<400>  191

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Tyr Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe His Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  192
<211>  2074
<212>  PRT
<213>  synthetic

<400>  192

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Phe Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe His Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  193
<211>  2074
<212>  PRT
<213>  synthetic

<400>  193

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Arg Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe His Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  194
<211>  2074
<212>  PRT
<213>  synthetic

<400>  194

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Thr Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Arg  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe His Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  195
<211>  2074
<212>  PRT
<213>  synthetic

<400>  195

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Glu Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn Glu Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Gln  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe His Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  196
<211>  2074
<212>  PRT
<213>  synthetic

<400>  196

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu 
            260                 265                 270         


Gly Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr 
        275                 280                 285             


Ser Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser 
    290                 295                 300                 


Lys Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His 
305                 310                 315                 320 


Gln Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys 
                325                 330                 335     


Leu Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln 
            340                 345                 350         


Gln Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr 
        355                 360                 365             


Asp Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys 
    370                 375                 380                 


Ala Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu 
385                 390                 395                 400 


Asp Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu 
                405                 410                 415     


Ile Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys 
            420                 425                 430         


Leu Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys 
        435                 440                 445             


Glu Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn 
    450                 455                 460                 


Tyr Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln 
465                 470                 475                 480 


Gly Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile 
                485                 490                 495     


Gln Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp 
            500                 505                 510         


Thr Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys 
        515                 520                 525             


Phe Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys 
    530                 535                 540                 


Asp His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys 
545                 550                 555                 560 


Ile Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe 
                565                 570                 575     


Gln Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr 
            580                 585                 590         


Leu Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu 
        595                 600                 605             


Ser Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu 
    610                 615                 620                 


Leu Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala 
625                 630                 635                 640 


Asp His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile 
                645                 650                 655     


Leu Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly 
            660                 665                 670         


Ala Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val 
        675                 680                 685             


Thr Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg 
    690                 695                 700                 


Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys 
705                 710                 715                 720 


Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn 
                725                 730                 735     


Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn 
            740                 745                 750         


Tyr Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys 
        755                 760                 765             


Asp Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala 
    770                 775                 780                 


Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe 
785                 790                 795                 800 


Ile Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile 
                805                 810                 815     


Tyr Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu 
            820                 825                 830         


Lys Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln 
        835                 840                 845             


Leu Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln 
    850                 855                 860                 


Gly Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg 
865                 870                 875                 880 


Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys 
                885                 890                 895     


Lys Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln 
            900                 905                 910         


Leu Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu 
        915                 920                 925             


Leu Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys 
    930                 935                 940                 


Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val 
945                 950                 955                 960 


Glu His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile 
                965                 970                 975     


Gln Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg 
            980                 985                 990         


Asn Thr Lys Gly Lys Cys Glu Lys  Glu Ile Phe Asn Leu  Ile Cys Lys 
        995                 1000                 1005             


Ile Glu  Gly Ser Glu Asp Lys  Lys Gly Asn Tyr Lys  His Gly Leu 
    1010                 1015                 1020             


Ala Tyr  Glu Leu Gly Val Leu  Leu Phe Gly Glu Pro  Asn Glu Ala 
    1025                 1030                 1035             


Ser Lys  Pro Glu Phe Asp Arg  Lys Ile Lys Lys Phe  Asn Ser Ile 
    1040                 1045                 1050             


Tyr Ser  Phe Ala Gln Ile Gln  Gln Ile Ala Phe Ala  Glu Arg Lys 
    1055                 1060                 1065             


Gly Asn  Ala Asn Thr Cys Ala  Val Cys Ser Ala Asp  Asn Ala His 
    1070                 1075                 1080             


Arg Met  Gln Gln Ile Lys Ile  Thr Glu Pro Val Glu  Asp Asn Lys 
    1085                 1090                 1095             


Asp Lys  Ile Ile Leu Ser Ala  Lys Ala Gln Arg Leu  Pro Ala Ile 
    1100                 1105                 1110             


Pro Thr  Arg Ile Val Asp Gly  Ala Val Lys Lys Met  Ala Thr Ile 
    1115                 1120                 1125             


Leu Ala  Lys Asn Ile Val Asp  Asp Asn Trp Gln Asn  Ile Lys Gln 
    1130                 1135                 1140             


Val Leu  Ser Ala Lys His Gln  Leu His Ile Pro Ile  Ile Thr Glu 
    1145                 1150                 1155             


Ser Asn  Ala Phe Glu Phe Glu  Pro Ala Leu Ala Asp  Val Lys Gly 
    1160                 1165                 1170             


Lys Ser  Leu Lys Asp Arg Arg  Lys Lys Ala Leu Glu  Arg Ile Ser 
    1175                 1180                 1185             


Pro Glu  Asn Ile Phe Lys Asp  Lys Asn Asn Arg Ile  Lys Glu Phe 
    1190                 1195                 1200             


Ala Lys  Gly Ile Ser Ala Tyr  Ser Gly Ala Asn Leu  Thr Asp Gly 
    1205                 1210                 1215             


Asp Phe  Asp Gly Ala Lys Glu  Glu Leu Asp His Ile  Ile Pro Arg 
    1220                 1225                 1230             


Ser His  Lys Lys Tyr Gly Thr  Leu Asn Asp Glu Ala  Asn Leu Ile 
    1235                 1240                 1245             


Cys Val  Thr Arg Gly Asp Asn  Lys Asn Lys Gly Asn  Arg Ile Phe 
    1250                 1255                 1260             


Cys Leu  Arg Asp Leu Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu 
    1265                 1270                 1275             


Thr Thr  Asp Asp Leu Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile 
    1280                 1285                 1290             


Trp Asp  Ala Asn Lys Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser 
    1295                 1300                 1305             


Phe Ile  Asn Leu Thr Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala 
    1310                 1315                 1320             


Leu Phe  Leu Ala Asp Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg 
    1325                 1330                 1335             


Ala Ile  Asn Asn Arg Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg 
    1340                 1345                 1350             


Tyr Phe  Ala Glu Val Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys 
    1355                 1360                 1365             


Lys Glu  Asn Leu Asn Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly 
    1370                 1375                 1380             


Ile Pro  Thr Ile Gly Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln 
    1385                 1390                 1395             


Leu Tyr  Glu Lys Val Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly 
    1400                 1405                 1410             


Asp Lys  Pro Gln Ala Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu 
    1415                 1420                 1425             


Ala Phe  Cys Ile Ala Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile 
    1430                 1435                 1440             


Gly Leu  Glu Ile Asp Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys 
    1445                 1450                 1455             


Asn Thr  Gly Glu Val Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys 
    1460                 1465                 1470             


Ile Thr  Asp Asn Glu Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys 
    1475                 1480                 1485             


Ala Ile  Glu Gly Phe Asn Thr  His Arg Gln Met Thr  Arg Asp Gly 
    1490                 1495                 1500             


Ile Tyr  Ala Glu Asn Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu 
    1505                 1510                 1515             


Asn Glu  Val Arg Lys Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile 
    1520                 1525                 1530             


Lys Ile  Phe Lys Gly Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn 
    1535                 1540                 1545             


Leu Val  Tyr Cys Leu Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp 
    1550                 1555                 1560             


Ile Gln  Ile Ser Thr Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr 
    1565                 1570                 1575             


Asn Asn  Ile Ala Ala Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys 
    1580                 1585                 1590             


Thr Gln  Lys Leu His Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala 
    1595                 1600                 1605             


Leu Gly  Tyr Lys Lys Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser 
    1610                 1615                 1620             


Leu Ala  Tyr Arg Ser Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp 
    1625                 1630                 1635             


Val Lys  Gln Val Leu Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys 
    1640                 1645                 1650             


Ile Thr  Leu Pro Phe Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu 
    1655                 1660                 1665             


Trp Gln  Asn Thr Thr Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser 
    1670                 1675                 1680             


Phe Phe  Asn Val Lys Ser Ile  Thr Lys Leu His Lys  Lys Val Arg 
    1685                 1690                 1695             


Lys Asp  Phe Ser Leu Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu 
    1700                 1705                 1710             


Val Lys  Arg Lys Thr Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu 
    1715                 1720                 1725             


Asn Asp  Ser Asp Ser Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro 
    1730                 1735                 1740             


Ala Phe  Asp Ile Ser Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp 
    1745                 1750                 1755             


Ser Phe  Thr Ser Lys Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu 
    1760                 1765                 1770             


Leu Gln  Lys Val Asp Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser 
    1775                 1780                 1785             


Lys Trp  Phe Glu Val Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly 
    1790                 1795                 1800             


Ile Ala  Thr Ile Gln Tyr Lys  Ile Asp Asn Asn Ser  Gln Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  197
<211>  2074
<212>  PRT
<213>  synthetic

<400>  197

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Ala 
            20                  25                  30          


Ala Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Ser Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly 
            260                 265                 270         


Val Lys Asn Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser 
        275                 280                 285             


Leu Glu Arg Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys 
    290                 295                 300                 


Asp Ser Tyr Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln 
305                 310                 315                 320 


Arg Arg Gly Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu 
                325                 330                 335     


Ile Trp Thr Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln 
            340                 345                 350         


Ala Ile Ser Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp 
        355                 360                 365             


Gly Tyr Ser Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala 
    370                 375                 380                 


Ile Leu Met Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp 
385                 390                 395                 400 


Ser Tyr Leu Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile 
                405                 410                 415     


Tyr Asn Lys Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu 
            420                 425                 430         


Cys Thr Asp Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu 
        435                 440                 445             


Ile Thr Ser Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr 
    450                 455                 460                 


Ser Glu Ser Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly 
465                 470                 475                 480 


Asn Leu Lys Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln 
                485                 490                 495     


Glu Phe Leu Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr 
            500                 505                 510         


Leu Leu Thr Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe 
        515                 520                 525             


Asp Phe Asp Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp 
    530                 535                 540                 


His Ile Gln Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile 
545                 550                 555                 560 


Lys Ser Glu Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln 
                565                 570                 575     


Glu Ile Thr Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu 
            580                 585                 590         


Lys Asn Phe Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser 
        595                 600                 605             


Val Lys Asn Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu 
    610                 615                 620                 


Lys Pro Leu Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp 
625                 630                 635                 640 


His Trp Asp Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu 
                645                 650                 655     


Gly Glu Trp Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala 
            660                 665                 670         


Lys Tyr Ser Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr 
        675                 680                 685             


Lys Ala Gly Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr 
    690                 695                 700                 


Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln 
705                 710                 715                 720 


Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp 
                725                 730                 735     


Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr 
            740                 745                 750         


Leu Asp Ser Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp 
        755                 760                 765             


Gln Pro Tyr Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser 
    770                 775                 780                 


Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile 
785                 790                 795                 800 


Phe Asp Arg Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr 
                805                 810                 815     


Phe Gln Ala Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys 
            820                 825                 830         


Leu Glu Ser Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu 
        835                 840                 845             


Ser Gln Ile Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly 
    850                 855                 860                 


Thr Phe Leu His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala 
865                 870                 875                 880 


Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys 
                885                 890                 895     


Leu His Lys Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu 
            900                 905                 910         


Leu Thr Tyr Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu 
        915                 920                 925             


Asn Asp Leu Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp 
    930                 935                 940                 


Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu 
945                 950                 955                 960 


His Ile Arg Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln 
                965                 970                 975     


Lys Asp Asn Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn 
            980                 985                 990         


Thr Lys Gly Lys Cys Glu Lys Glu  Ile Phe Asn Leu Ile  Cys Lys Ile 
        995                 1000                 1005             


Glu Gly  Ser Glu Asp Lys Lys  Gly Asn Tyr Lys His  Gly Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Leu Gly Val Leu Leu  Phe Gly Glu Pro Asn  Glu Ala Ser 
    1025                 1030                 1035             


Lys Pro  Glu Phe Asp Arg Lys  Ile Lys Lys Phe Asn  Ser Ile Tyr 
    1040                 1045                 1050             


Ser Phe  Ala Gln Ile Gln Gln  Ile Ala Phe Ala Glu  Arg Lys Gly 
    1055                 1060                 1065             


Asn Ala  Asn Thr Cys Ala Val  Cys Ser Ala Asp Asn  Ala His Arg 
    1070                 1075                 1080             


Met Gln  Gln Ile Lys Ile Thr  Glu Pro Val Glu Asp  Asn Lys Asp 
    1085                 1090                 1095             


Lys Ile  Ile Leu Ser Ala Lys  Ala Gln Arg Leu Pro  Ala Ile Pro 
    1100                 1105                 1110             


Thr Arg  Ile Val Asp Gly Ala  Val Lys Lys Met Ala  Thr Ile Leu 
    1115                 1120                 1125             


Ala Lys  Asn Ile Val Asp Asp  Asn Trp Gln Asn Ile  Lys Gln Val 
    1130                 1135                 1140             


Leu Ser  Ala Lys His Gln Leu  His Ile Pro Ile Ile  Thr Glu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Glu Phe Glu Pro  Ala Leu Ala Asp Val  Lys Gly Lys 
    1160                 1165                 1170             


Ser Leu  Lys Asp Arg Arg Lys  Lys Ala Leu Glu Arg  Ile Ser Pro 
    1175                 1180                 1185             


Glu Asn  Ile Phe Lys Asp Lys  Asn Asn Arg Ile Lys  Glu Phe Ala 
    1190                 1195                 1200             


Lys Gly  Ile Ser Ala Tyr Ser  Gly Ala Asn Leu Thr  Asp Gly Asp 
    1205                 1210                 1215             


Phe Asp  Gly Ala Lys Glu Glu  Leu Asp His Ile Ile  Pro Arg Ser 
    1220                 1225                 1230             


His Lys  Lys Tyr Gly Thr Leu  Asn Asp Glu Ala Asn  Leu Ile Cys 
    1235                 1240                 1245             


Val Thr  Arg Gly Asp Asn Lys  Asn Lys Gly Asn Arg  Ile Phe Cys 
    1250                 1255                 1260             


Leu Arg  Asp Leu Ala Asp Asn  Tyr Lys Leu Lys Gln  Phe Glu Thr 
    1265                 1270                 1275             


Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile Ala Asp  Thr Ile Trp 
    1280                 1285                 1290             


Asp Ala  Asn Lys Lys Asp Phe  Lys Phe Gly Asn Tyr  Arg Ser Phe 
    1295                 1300                 1305             


Ile Asn  Leu Thr Pro Gln Glu  Gln Lys Ala Phe Arg  His Ala Leu 
    1310                 1315                 1320             


Phe Leu  Ala Asp Glu Asn Pro  Ile Lys Gln Ala Val  Ile Arg Ala 
    1325                 1330                 1335             


Ile Asn  Asn Arg Asn Arg Thr  Phe Val Asn Gly Thr  Gln Arg Tyr 
    1340                 1345                 1350             


Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr Leu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Asn  Leu Asn Thr Asp Lys  Ile Ser Phe Asp Tyr  Phe Gly Ile 
    1370                 1375                 1380             


Pro Thr  Ile Gly Asn Gly Arg  Gly Ile Ala Glu Ile  Arg Gln Leu 
    1385                 1390                 1395             


Tyr Glu  Lys Val Asp Ser Asp  Ile Gln Ala Tyr Ala  Lys Gly Asp 
    1400                 1405                 1410             


Lys Pro  Gln Ala Ser Tyr Ser  His Leu Ile Asp Ala  Met Leu Ala 
    1415                 1420                 1425             


Phe Cys  Ile Ala Ala Asp Glu  His Arg Asn Asp Gly  Ser Ile Gly 
    1430                 1435                 1440             


Leu Glu  Ile Asp Lys Asn Tyr  Ser Leu Tyr Pro Leu  Asp Lys Asn 
    1445                 1450                 1455             


Thr Gly  Glu Val Phe Thr Lys  Asp Ile Phe Ser Gln  Ile Lys Ile 
    1460                 1465                 1470             


Thr Asp  Asn Glu Phe Ser Asp  Lys Lys Leu Val Arg  Lys Lys Ala 
    1475                 1480                 1485             


Ile Glu  Gly Phe Asn Thr His  Arg Gln Met Thr Arg  Asp Gly Ile 
    1490                 1495                 1500             


Tyr Ala  Glu Asn Tyr Leu Pro  Ile Leu Ile His Lys  Glu Leu Asn 
    1505                 1510                 1515             


Glu Val  Arg Lys Gly Tyr Thr  Trp Lys Asn Ser Glu  Glu Ile Lys 
    1520                 1525                 1530             


Ile Phe  Lys Gly Lys Lys Tyr  Asp Ile Gln Gln Leu  Asn Asn Leu 
    1535                 1540                 1545             


Val Tyr  Cys Leu Lys Phe Val  Asp Lys Pro Ile Ser  Ile Asp Ile 
    1550                 1555                 1560             


Gln Ile  Ser Thr Leu Glu Glu  Leu Arg Asn Ile Leu  Thr Thr Asn 
    1565                 1570                 1575             


Asn Ile  Ala Ala Thr Ala Glu  Tyr Tyr Tyr Ile Asn  Leu Lys Thr 
    1580                 1585                 1590             


Gln Lys  Leu His Glu Tyr Tyr  Ile Glu Asn Tyr Asn  Thr Ala Leu 
    1595                 1600                 1605             


Gly Tyr  Lys Lys Tyr Ser Lys  Glu Met Glu Phe Leu  Arg Ser Leu 
    1610                 1615                 1620             


Ala Tyr  Arg Ser Arg Arg Val  Lys Ile Lys Ser Ile  Asp Asp Val 
    1625                 1630                 1635             


Lys Gln  Val Leu Asp Lys Asp  Ser Asn Phe Ile Ile  Gly Lys Ile 
    1640                 1645                 1650             


Thr Leu  Pro Phe Lys Lys Glu  Trp Gln Arg Leu Tyr  Arg Glu Trp 
    1655                 1660                 1665             


Gln Asn  Thr Thr Ile Lys Asp  Asp Tyr Glu Phe Leu  Lys Ser Phe 
    1670                 1675                 1680             


Phe Asn  Val Lys Ser Ile Thr  Lys Leu His Lys Lys  Val Arg Lys 
    1685                 1690                 1695             


Asp Phe  Ser Leu Pro Ile Ser  Thr Asn His Gly Lys  Phe Leu Val 
    1700                 1705                 1710             


Lys Arg  Lys Thr Trp Asp Asn  Asn Phe Ile Tyr Gln  Ile Leu Asn 
    1715                 1720                 1725             


Asp Ser  Asp Ser Arg Ala Asp  Gly Thr Lys Pro Phe  Ile Pro Ala 
    1730                 1735                 1740             


Phe Asp  Ile Ser Lys Asn Glu  Ile Val Glu Ala Ile  Ile Asp Ser 
    1745                 1750                 1755             


Phe Thr  Ser Lys Asn Ile Phe  Trp Leu Pro Lys Asn  Ile Glu Leu 
    1760                 1765                 1770             


Gln Lys  Val Asp Asn Lys Asn  Ile Phe Ala Ile Asp  Thr Ser Lys 
    1775                 1780                 1785             


Trp Phe  Glu Val Glu Thr Pro  Ser Asp Leu Arg Asp  Ile Gly Ile 
    1790                 1795                 1800             


Ala Thr  Ile Gln Tyr Lys Ile  Asp Asn Asn Ser Gln  Pro Lys Val 
    1805                 1810                 1815             


Arg Val  Lys Leu Asp Tyr Val  Ile Asp Asp Asp Ser  Lys Ile Asn 
    1820                 1825                 1830             


Tyr Phe  Met Asn His Ser Leu  Leu Lys Ser Arg Tyr  Pro Asp Lys 
    1835                 1840                 1845             


Val Leu  Glu Ile Leu Lys Gln  Ser Thr Ile Ile Glu  Phe Glu Ser 
    1850                 1855                 1860             


Ser Gly  Phe Asn Lys Thr Ile  Lys Glu Met Leu Gly  Met Lys Leu 
    1865                 1870                 1875             


Ala Gly  Ile Tyr Asn Glu Thr  Ser Asn Asn Ser Gly  Gly Ser Gly 
    1880                 1885                 1890             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1895                 1900                 1905             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1910                 1915                 1920             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1925                 1930                 1935             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1940                 1945                 1950             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1955                 1960                 1965             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1970                 1975                 1980             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1985                 1990                 1995             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    2000                 2005                 2010             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    2015                 2020                 2025             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    2030                 2035                 2040             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    2045                 2050                 2055             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    2060                 2065                 2070             


Leu 
    


<210>  198
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  198
taatacgact cactatagga aattaggtgc gcttggcgtt tcagttgcgc cgaaaggcgc       60

tctgtaatca tt                                                           72


<210>  199
<211>  73
<212>  DNA
<213>  Homo sapiens

<400>  199
taatacgact cactataggg aaattaggtg cgcttggcgt ttcagttgcg ccgaaaggcg       60

ctctgtaatc att                                                          73


<210>  200
<211>  74
<212>  DNA
<213>  Homo sapiens

<400>  200
taatacgact cactataggg gaaattaggt gcgcttggcg tttcagttgc gccgaaaggc       60

gctctgtaat catt                                                         74


<210>  201
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  201
taatacgact cactataggg ggaaattagg tgcgcttggc gtttcagttg cgccgaaagg       60

cgctctgtaa tcatt                                                        75


<210>  202
<211>  76
<212>  DNA
<213>  Homo sapiens

<400>  202
taatacgact cactataggg gggaaattag gtgcgcttgg cgtttcagtt gcgccgaaag       60

gcgctctgta atcatt                                                       76


<210>  203
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  203
gagtccgagc agaagaagaa                                                   20


<210>  204
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  204
gagttagagc agaagaagaa                                                   20


<210>  205
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  205
gagtctaagc agaagaagaa                                                   20


<210>  206
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  206
gtaacggcag acttctcctc                                                   20


<210>  207
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  207
ggaaaggcag acttctcctt                                                   20


<210>  208
<211>  20
<212>  DNA
<213>  synthetic

<400>  208
gcattttcag gaggaagcga                                                   20


<210>  209
<211>  20
<212>  DNA
<213>  synthetic

<400>  209
gcattttcag aaggaagcaa                                                   20


<210>  210
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  210
gctgcagaag ggattccatg                                                   20


<210>  211
<211>  20
<212>  DNA
<213>  synthetic

<400>  211
gctgcagaag ggattccaag                                                   20


<210>  212
<211>  20
<212>  DNA
<213>  synthetic

<400>  212
gctattggtc aaggcaaggc                                                   20


<210>  213
<211>  21
<212>  DNA
<213>  synthetic

<400>  213
ggctattggt caaggcaagg c                                                 21


<210>  214
<211>  20
<212>  DNA
<213>  synthetic

<400>  214
tttatcacag gctccaggaa                                                   20


<210>  215
<211>  20
<212>  DNA
<213>  synthetic

<400>  215
ttttatcaca ggctccagga                                                   20


<210>  216
<211>  34
<212>  DNA
<213>  Francisella novicida

<400>  216
cgacgcgtga aagatcaaaa gtattgacga tgtc                                   34


<210>  217
<211>  30
<212>  DNA
<213>  Francisella novicida

<400>  217
agacctacct caggaactct aagccaggga                                        30


<210>  218
<211>  34
<212>  DNA
<213>  Francisella novicida

<400>  218
cacggcaagt ttctggtgaa gagaaaaact tggg                                   34


<210>  219
<211>  33
<212>  DNA
<213>  Francisella novicida

<400>  219
gtttgtactg atgggcagag agaagtcttt ccg                                    33


<210>  220
<211>  33
<212>  DNA
<213>  synthetic

<400>  220
cgccccaagg tgcgagtcaa actggattac gtg                                    33


<210>  221
<211>  33
<212>  DNA
<213>  Francisella novicida

<400>  221
acaatctatg cagagaatta cctgcctatc ctg                                    33


<210>  222
<211>  35
<212>  DNA
<213>  Francisella novicida

<400>  222
atccctagtc atctgtctgt gtgtgtgtta aaccc                                  35


<210>  223
<211>  34
<212>  DNA
<213>  Francisella novicida

<400>  223
tatcgcgtga aagatcaaaa gtattgacga tgtc                                   34


<210>  224
<211>  34
<212>  DNA
<213>  Francisella novicida

<400>  224
cgaaagatca cactgccctt caagaaagag tggc                                   34


<210>  225
<211>  34
<212>  DNA
<213>  Francisella novicida

<400>  225
gcaggtcctg gacaaggatt caaacttcat catc                                   34


<210>  226
<211>  34
<212>  DNA
<213>  Francisella novicida

<400>  226
aaaaagatca cactgccctt caagaaagag tggc                                   34


<210>  227
<211>  35
<212>  DNA
<213>  Francisella novicida

<400>  227
agggagggca agtttctggt gaagagaaaa acttg                                  35


<210>  228
<211>  33
<212>  DNA
<213>  Francisella novicida

<400>  228
tgtactgatg ggcagagaga agtctttccg gac                                    33


<210>  229
<211>  35
<212>  DNA
<213>  Francisella novicida

<400>  229
tacgagggca agtttctggt gaagagaaaa acttg                                  35


<210>  230
<211>  35
<212>  DNA
<213>  Francisella novicida

<400>  230
gtgtttctgg tgaagagaaa aacttgggat aataa                                  35


<210>  231
<211>  33
<212>  DNA
<213>  Francisella novicida

<400>  231
gccctcgttt gtactgatgg gcagagagaa gtc                                    33


<210>  232
<211>  34
<212>  DNA
<213>  Francisella novicida

<400>  232
accagggcag acgggactaa acccttcatt cctg                                   34


<210>  233
<211>  31
<212>  DNA
<213>  Francisella novicida

<400>  233
atctgagtca ttcagaatct ggtagatgaa g                                      31


<210>  234
<211>  33
<212>  DNA
<213>  Francisella novicida

<400>  234
gtgaactcac gccccaaggt gcgagtcaaa ctg                                    33


<210>  235
<211>  31
<212>  DNA
<213>  Francisella novicida

<400>  235
cggcattgct accattcagt acaagatcga c                                      31


<210>  236
<211>  33
<212>  DNA
<213>  Francisella novicida

<400>  236
caccccgaca aagtcctgga gatcctgaag cag                                    33


<210>  237
<211>  34
<212>  DNA
<213>  Francisella novicida

<400>  237
ccggctcttc agcagtgagt gattcatgaa atag                                   34


<210>  238
<211>  33
<212>  DNA
<213>  Francisella novicida

<400>  238
cggcccgaca aagtcctgga gatcctgaag cag                                    33


<210>  239
<211>  33
<212>  DNA
<213>  Francisella novicida

<400>  239
cacagttcag ggtttaacaa aactattaag gag                                    33


<210>  240
<211>  33
<212>  DNA
<213>  Francisella novicida

<400>  240
gaactcaatg attgtgctct gcttcaggat ctc                                    33


<210>  241
<211>  33
<212>  DNA
<213>  Francisella novicida

<400>  241
actcccaagg tgcgagtcaa actggattac gtg                                    33


<210>  242
<211>  33
<212>  DNA
<213>  Francisella novicida

<400>  242
tgagttattg tcgatcttgt actgaatggt agc                                    33


<210>  243
<211>  32
<212>  DNA
<213>  Francisella novicida

<400>  243
tataacacac acagacagat gactagggat gg                                     32


<210>  244
<211>  31
<212>  DNA
<213>  Francisella novicida

<400>  244
cccttcaata gctttctttc tgaccagttt c                                      31


<210>  245
<211>  34
<212>  DNA
<213>  Francisella novicida

<400>  245
tttgacggga ctaaaccctt cattcctgcc tttg                                   34


<210>  246
<211>  34
<212>  DNA
<213>  Francisella novicida

<400>  246
cctgctatct gagtcattca gaatctggta gatg                                   34


<210>  247
<211>  32
<212>  DNA
<213>  Francisella novicida

<400>  247
catttcacct caaaaaacat cttttggctg cc                                     32


<210>  248
<211>  32
<212>  DNA
<213>  Francisella novicida

<400>  248
gtcaatgatg gcttccacaa tctcgttctt gc                                     32


<210>  249
<211>  33
<212>  DNA
<213>  Francisella novicida

<400>  249
cgtctgctga agagccggta tcccgacaaa gtc                                    33


<210>  250
<211>  34
<212>  DNA
<213>  Francisella novicida

<400>  250
gtgattcatg aaatagttaa tcttgctgtc atcg                                   34


<210>  251
<211>  33
<212>  DNA
<213>  Francisella novicida

<400>  251
cgtagccggt atcccgacaa agtcctggag atc                                    33


<210>  252
<211>  35
<212>  DNA
<213>  Francisella novicida

<400>  252
cagcagtgag tgattcatga aatagttaat cttgc                                  35


<210>  253
<211>  34
<212>  DNA
<213>  Francisella novicida

<400>  253
gtgactatta aggagatgct gggaatgaag ctgg                                   34


<210>  254
<211>  34
<212>  DNA
<213>  Francisella novicida

<400>  254
gttaaaccct gaactttcga actcaatgat tgtg                                   34


<210>  255
<211>  34
<212>  DNA
<213>  Francisella novicida

<400>  255
tctactatta aggagatgct gggaatgaag ctgg                                   34


<210>  256
<211>  34
<212>  DNA
<213>  Francisella novicida

<400>  256
aacactatta aggagatgct gggaatgaag ctgg                                   34


<210>  257
<211>  35
<212>  DNA
<213>  Francisella novicida

<400>  257
tttgggttta acaaaactat taaggagatg ctggg                                  35


<210>  258
<211>  34
<212>  DNA
<213>  Francisella novicida

<400>  258
actttcgaac tcaatgattg tgctctgctt cagg                                   34


<210>  259
<211>  35
<212>  DNA
<213>  Francisella novicida

<400>  259
cgtgggttta acaaaactat taaggagatg ctggg                                  35


<210>  260
<211>  34
<212>  DNA
<213>  Francisella novicida

<400>  260
cgttcaaact tcatcatcgg aaagatcaca ctgc                                   34


<210>  261
<211>  35
<212>  DNA
<213>  Francisella novicida

<400>  261
tctcttgtcc aggacctgct tgacatcgtc aatac                                  35


<210>  262
<211>  33
<212>  DNA
<213>  Francisella novicida

<400>  262
cagcccaagg tgcgagtcaa actggattac gtg                                    33


<210>  263
<211>  35
<212>  DNA
<213>  Francisella novicida

<400>  263
ctggcttata ggtctaggcg cgtgaagatc aaaag                                  35


<210>  264
<211>  35
<212>  DNA
<213>  Francisella novicida

<400>  264
cttttgatct tcacgcgcct agacctataa gccag                                  35


<210>  265
<211>  44
<212>  DNA
<213>  Francisella novicida

<400>  265
cagagcacaa tcattgagtt ccacagttca gggtttaaca aaac                        44


<210>  266
<211>  44
<212>  DNA
<213>  Francisella novicida

<400>  266
gttttgttaa accctgaact gtggaactca atgattgtgc tctg                        44


<210>  267
<211>  35
<212>  DNA
<213>  Francisella novicida

<400>  267
ctggcttata ggtctaggcg cgtgaagatc aaaag                                  35


<210>  268
<211>  35
<212>  DNA
<213>  Francisella novicida

<400>  268
cttttgatct tcacgcgcct agacctataa gccag                                  35


<210>  269
<211>  44
<212>  DNA
<213>  Francisella novicida

<400>  269
cagagcacaa tcattgagtt ccacagttca gggtttaaca aaac                        44


<210>  270
<211>  44
<212>  DNA
<213>  Francisella novicida

<400>  270
gttttgttaa accctgaact gtggaactca atgattgtgc tctg                        44


<210>  271
<211>  38
<212>  DNA
<213>  synthetic

<400>  271
gacagatgac tagggatacc atctatgcag agaattac                               38


<210>  272
<211>  38
<212>  DNA
<213>  synthetic

<400>  272
gtaattctct gcatagatgg tatccctagt catctgtc                               38


<210>  273
<211>  39
<212>  DNA
<213>  synthetic

<400>  273
ctgcccatca gtacaaacca cggcaagttt ctggtgaag                              39


<210>  274
<211>  39
<212>  DNA
<213>  synthetic

<400>  274
cttcaccaga aacttgccgt ggtttgtact gatgggcag                              39


<210>  275
<211>  36
<212>  DNA
<213>  Francisella novicida

<400>  275
gccaccacta tagccgtcag taataaaaga gaatcc                                 36


<210>  276
<211>  38
<212>  DNA
<213>  Francisella novicida

<400>  276
ggttcagcag tcaataagat caaaagcgag atggcatc                               38


<210>  277
<211>  72
<212>  DNA
<213>  synthetic

<400>  277
taatacgact cactatagta acggcagact tctcctcgtt tcagttgcgc cgaaaggcgc       60

tctgtaatca tt                                                           72


<210>  278
<211>  20
<212>  DNA
<213>  synthetic

<400>  278
tctccacatg cccagtttct                                                   20


<210>  279
<211>  20
<212>  DNA
<213>  synthetic

<400>  279
agtcagggca gagccatcta                                                   20


<210>  280
<211>  73
<212>  DNA
<213>  synthetic

<400>  280
cagacgtgtc aaacagaggt ccgttcaaaa tacttttaaa tgattacaga gcgcctttcg       60

gcgcaactga aac                                                          73


<210>  281
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  281
tgtgggtgag tgagtgtgtg cgtgtggggt                                        30


<210>  282
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  282
accccacacg cacacactca ctcacccaca                                        30


<210>  283
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  283
actcctaagc cagtgccaga                                                   20


<210>  284
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  284
ggcagagaga gtcagtgcct a                                                 21


<210>  285
<211>  53
<212>  DNA
<213>  Homo sapiens

<400>  285
tcgtcggcag cgtcagatgt gtataagaga caggcctcct gagtttctca tct              53


<210>  286
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  286
gtctcgtggg ctcggagatg tgtataagag acaggttgcc caccctagtc attg             54


<210>  287
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  287
tcgtcggcag cgtcagatgt gtataagaga cagccatctt ggggttacag aaag             54


<210>  288
<211>  58
<212>  DNA
<213>  Homo sapiens

<400>  288
gtctcgtggg ctcggagatg tgtataagag acaggaaaca tttaccatag actatcac         58


<210>  289
<211>  53
<212>  DNA
<213>  Homo sapiens

<400>  289
tcgtcggcag cgtcagatgt gtataagaga cagtctccac atgcccagtt tct              53


<210>  290
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  290
gtctcgtggg ctcggagatg tgtataagag acagagtcag ggcagagcca tcta             54


<210>  291
<211>  53
<212>  DNA
<213>  Homo sapiens

<400>  291
tcgtcggcag cgtcagatgt gtataagaga caggaggggt tgctttcttg tga              53


<210>  292
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  292
gtctcgtggg ctcggagatg tgtataagag acagatgcac acagtggagc cttc             54


<210>  293
<211>  52
<212>  DNA
<213>  Homo sapiens

<400>  293
tcgtcggcag cgtcagatgt gtataagaga cagtagggct agaggggtga gg               52


<210>  294
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  294
gtctcgtggg ctcggagatg tgtataagag acagaagcac tgtgggtacg aagg             54


<210>  295
<211>  53
<212>  DNA
<213>  Homo sapiens

<400>  295
tcgtcggcag cgtcagatgt gtataagaga caggcatgat actttggggg aga              53


<210>  296
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  296
gtctcgtggg ctcggagatg tgtataagag acagcccaga aatttaattc caatcac          57


<210>  297
<211>  52
<212>  DNA
<213>  Homo sapiens

<400>  297
tcgtcggcag cgtcagatgt gtataagaga cagccaggtg ctgacgtagg ta               52


<210>  298
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  298
gtctcgtggg ctcggagatg tgtataagag acagtagcat tgcagagagg cgta             54


<210>  299
<211>  53
<212>  DNA
<213>  Homo sapiens

<400>  299
tcgtcggcag cgtcagatgt gtataagaga cagcccactc tctcctgttc tgg              53


<210>  300
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  300
gtctcgtggg ctcggagatg tgtataagag acagcccatt tctgtctcca cctc             54


<210>  301
<211>  53
<212>  DNA
<213>  synthetic

<400>  301
tcgtcggcag cgtcagatgt gtataagaga cagttcccca cactatctca atg              53


<210>  302
<211>  54
<212>  DNA
<213>  synthetic

<400>  302
gtctcgtggg ctcggagatg tgtataagag acagtattct tcatccctag ccag             54


<210>  303
<211>  55
<212>  DNA
<213>  synthetic

<400>  303
tcgtcggcag cgtcagatgt gtataagaga caggccagaa aagagatatg gcatc            55


<210>  304
<211>  53
<212>  DNA
<213>  synthetic

<400>  304
gtctcgtggg ctcggagatg tgtataagag acagccaccg atggagaggt ctg              53


<210>  305
<211>  61
<212>  RNA
<213>  synthetic

<400>  305
guaauuaaug cucuguaauc auuuaaaagu auuuugaacg gaccucuguu ugacacgucu       60

u                                                                       61


