                         SEQUENCE LISTING

<110>  Vilnius University
 
<120>  A NOVEL RNA-PROGRAMMABLE SYSTEM FOR TARGETING POLYNUCLEOTIDES

<130>  V83-87

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  408
<212>  PRT
<213>  Deinococcus radiodurans

<400>  1

Met Ile Arg Asn Lys Ala Phe Val Val Arg Leu Tyr Pro Asn Ala Ala 
1               5                   10                  15      


Gln Thr Glu Leu Ile Asn Arg Thr Leu Gly Ser Ala Arg Phe Val Tyr 
            20                  25                  30          


Asn His Phe Leu Ala Arg Arg Ile Ala Ala Tyr Lys Glu Ser Gly Lys 
        35                  40                  45              


Gly Leu Thr Tyr Gly Gln Thr Ser Ser Glu Leu Thr Leu Leu Lys Gln 
    50                  55                  60                  


Ala Glu Glu Thr Ser Trp Leu Ser Glu Val Asp Lys Phe Ala Leu Gln 
65                  70                  75                  80  


Asn Ser Leu Lys Asn Leu Glu Thr Ala Tyr Lys Asn Phe Phe Arg Thr 
                85                  90                  95      


Val Lys Gln Ser Gly Lys Lys Val Gly Phe Pro Arg Phe Arg Lys Lys 
            100                 105                 110         


Arg Thr Gly Glu Ser Tyr Arg Thr Gln Phe Thr Asn Asn Asn Ile Gln 
        115                 120                 125             


Ile Gly Glu Gly Arg Leu Lys Leu Pro Lys Leu Gly Trp Val Lys Thr 
    130                 135                 140                 


Lys Gly Gln Gln Asp Ile Gln Gly Lys Ile Leu Asn Val Thr Val Arg 
145                 150                 155                 160 


Arg Ile His Glu Gly His Tyr Glu Ala Ser Val Leu Cys Glu Val Glu 
                165                 170                 175     


Ile Pro Tyr Leu Pro Ala Ala Pro Lys Phe Ala Ala Gly Val Asp Val 
            180                 185                 190         


Gly Ile Lys Asp Phe Ala Ile Val Thr Asp Gly Val Arg Phe Lys His 
        195                 200                 205             


Glu Gln Asn Pro Lys Tyr Tyr Arg Ser Thr Leu Lys Arg Leu Arg Lys 
    210                 215                 220                 


Ala Gln Gln Thr Leu Ser Arg Arg Lys Lys Gly Ser Ala Arg Tyr Gly 
225                 230                 235                 240 


Lys Ala Lys Thr Lys Leu Ala Arg Ile His Lys Arg Ile Val Asn Lys 
                245                 250                 255     


Arg Gln Asp Phe Leu His Lys Leu Thr Thr Ser Leu Val Arg Glu Tyr 
            260                 265                 270         


Glu Ile Ile Gly Thr Glu His Leu Lys Pro Asp Asn Met Arg Lys Asn 
        275                 280                 285             


Arg Arg Leu Ala Leu Ser Ile Ser Asp Ala Gly Trp Gly Glu Phe Ile 
    290                 295                 300                 


Arg Gln Leu Glu Tyr Lys Ala Ala Trp Tyr Gly Arg Leu Val Ser Lys 
305                 310                 315                 320 


Val Ser Pro Tyr Phe Pro Ser Ser Gln Leu Cys His Asp Cys Gly Phe 
                325                 330                 335     


Lys Asn Pro Glu Val Lys Asn Leu Ala Val Arg Thr Trp Thr Cys Pro 
            340                 345                 350         


Asn Cys Gly Glu Thr His Asp Arg Asp Glu Asn Ala Ala Leu Asn Ile 
        355                 360                 365             


Arg Arg Glu Ala Leu Val Ala Ala Gly Ile Ser Asp Thr Leu Asn Ala 
    370                 375                 380                 


His Gly Gly Tyr Val Arg Pro Ala Ser Ala Gly Asn Gly Leu Arg Ser 
385                 390                 395                 400 


Glu Asn His Ala Thr Leu Val Val 
                405             


<210>  2
<211>  383
<212>  PRT
<213>  Helicobacter pylori

<400>  2

Met Leu Ile Thr Tyr Lys Gln Lys Leu Tyr Lys Asn Asp Lys Asn Arg 
1               5                   10                  15      


Arg Ile Asp Thr Leu Leu Arg Arg Tyr Gly Ala Leu Tyr Asn His Cys 
            20                  25                  30          


Ile Ala Leu His Lys Arg Tyr Tyr Arg Leu Phe Lys Lys Tyr Leu Lys 
        35                  40                  45              


Leu Tyr Asp Leu Gln Lys His Ile Thr Lys Leu Lys Lys Thr His Arg 
    50                  55                  60                  


Tyr Ala Phe Leu Lys Thr Leu Gly Ser Gln Thr Met Gln Asp Leu Thr 
65                  70                  75                  80  


Glu Arg Ile Asp Lys Ala Phe Lys Lys Phe Phe Asn Lys Lys Ala Lys 
                85                  90                  95      


Leu Pro Arg Phe Lys Lys Val Ala Asn Tyr Lys Ser Phe Thr Phe Lys 
            100                 105                 110         


Ser Lys Ile Asp Lys Lys Thr Gly Leu Asn Lys Gly Val Gly Phe Ala 
        115                 120                 125             


Ile Lys Asp Asn Val Val Ser Phe Asn Gly Tyr Ser Tyr Lys Phe Ile 
    130                 135                 140                 


Lys Thr Tyr Ala Phe Ile Gly Lys Val Lys Thr Leu Thr Ile Lys Arg 
145                 150                 155                 160 


Asp Asn Thr Gly Asp Tyr Phe Leu Cys Leu Val Cys Glu Leu Glu Asn 
                165                 170                 175     


His Pro Asn Lys Gln Thr Ala Cys Asp Lys Ser Val Gly Phe Asp Phe 
            180                 185                 190         


Gly Leu Lys Thr Phe Leu Thr Gly Ser Asp His Thr Lys Ile Glu Ser 
        195                 200                 205             


Pro Leu Ser Phe Ser Lys Tyr Leu Pro Leu Ile Lys Arg Leu Ser Lys 
    210                 215                 220                 


Asn Leu Ser Lys Lys Val Lys Gly Ser Asn Asn Phe Lys Lys Ala Lys 
225                 230                 235                 240 


Lys Lys Leu Thr Gln Leu His Gln Lys Ile Lys Tyr Leu Arg Thr Asp 
                245                 250                 255     


Phe Phe His Lys Leu Ala Leu Lys Leu Ser Arg Glu Tyr Gln Thr Ile 
            260                 265                 270         


Phe Ile Glu Asp Leu Asn Met Lys Ala Met Gln Lys Leu Trp Gly Arg 
        275                 280                 285             


Lys Val Ser Asp Leu Ala Phe Ser Glu Phe Val Lys Ile Leu Glu Asn 
    290                 295                 300                 


Lys Ala Asn Val Val Lys Ile Asp Arg Phe Tyr Pro Ser Ser Lys Thr 
305                 310                 315                 320 


Cys Ser Asn Cys Leu Phe Val Asn Glu Glu Ile Asn Lys Asp Phe Arg 
                325                 330                 335     


Lys Ile Gly Lys Thr Asp Lys Glu Arg Glu Tyr His Cys Lys Tyr Cys 
            340                 345                 350         


Gly Leu Glu Leu Asp Arg Asp Leu Asn Ala Ala Ile Asn Ile His Arg 
        355                 360                 365             


Val Gly Ala Ser Thr Leu Gly Val Glu Phe Val Arg Pro Thr Cys 
    370                 375                 380             


<210>  3
<211>  427
<212>  PRT
<213>  Helicobacter pylori

<400>  3

Met Leu Asn Ala Ile Lys Phe Arg Ile Tyr Pro Asn Ala Gln Gln Lys 
1               5                   10                  15      


Glu Leu Ile Ser Lys His Phe Gly Cys Ser Arg Val Val Tyr Asn Tyr 
            20                  25                  30          


Phe Leu Asp Tyr Arg Gln Lys Gln Tyr Ala Lys Gly Ile Lys Glu Thr 
        35                  40                  45              


Tyr Phe Thr Met Gln Lys Val Leu Thr Gln Ile Lys His Gln Glu Lys 
    50                  55                  60                  


Tyr His Tyr Leu Asn Glu Cys Asn Ser Gln Ser Leu Gln Met Ala Leu 
65                  70                  75                  80  


Arg Gln Leu Val Ser Ala Tyr Asp Asn Phe Phe Ser Lys Arg Ala Arg 
                85                  90                  95      


Tyr Pro Lys Phe Lys Ser Lys Lys Asn Ala Lys Gln Ser Phe Ala Ile 
            100                 105                 110         


Pro Gln Asn Ile Glu Ile Lys Thr Glu Thr Gln Thr Ile Ala Leu Pro 
        115                 120                 125             


Lys Phe Lys Glu Gly Ile Lys Ala Lys Leu His Arg Glu Leu Pro Lys 
    130                 135                 140                 


Asp Ser Val Ile Lys Gln Ala Phe Ile Ser Cys Ile Ala Asp Gln Tyr 
145                 150                 155                 160 


Phe Cys Ser Ile Ser Tyr Glu Thr Lys Glu Pro Ile Pro Lys Pro Thr 
                165                 170                 175     


Ile Ile Lys Lys Ala Val Gly Leu Asp Met Gly Leu Arg Thr Leu Ile 
            180                 185                 190         


Val Thr Ser Asp Lys Ile Glu Tyr Pro His Ile Arg Phe Tyr Gln Lys 
        195                 200                 205             


Leu Glu Lys Lys Leu Thr Lys Ala Gln Arg Arg Leu Ser Lys Lys Val 
    210                 215                 220                 


Lys Gly Ser Asn Asn Arg Lys Lys Gln Ala Lys Lys Val Ala Arg Leu 
225                 230                 235                 240 


His Leu Ala Cys Ser Asn Thr Arg Asp Asp Tyr Leu His Lys Ile Ser 
                245                 250                 255     


Asn Glu Ile Thr Asn Gln Tyr Asp Leu Ile Gly Val Glu Thr Leu Asn 
            260                 265                 270         


Val Lys Gly Leu Met Arg Thr Tyr His Ser Lys Ser Leu Ala Asn Ala 
        275                 280                 285             


Ser Trp Gly Lys Phe Leu Thr Met Leu Lys Tyr Lys Ala Gln Arg Lys 
    290                 295                 300                 


Ala Lys Thr Leu Leu Gly Ile Asp Arg Phe Phe Pro Ser Ser Gln Leu 
305                 310                 315                 320 


Cys Ser Tyr Cys Gly Phe Asn Thr Gly Lys Lys His Glu Asn Ile Thr 
                325                 330                 335     


Lys Phe Thr Cys Pro His Cys Asn Ile Thr His His Arg Asp Tyr Asn 
            340                 345                 350         


Ala Ser Val Asn Ile Arg Asn Tyr Ala Leu Gly Met Leu Asp Asp Arg 
        355                 360                 365             


His Lys Ile Lys Ile Asp Lys Ser Arg Val Gly Ile Ile Arg Thr Asp 
    370                 375                 380                 


Tyr Ala His Tyr Thr Asp Glu Arg Ile Lys Ala Cys Gly Ala Ser Ser 
385                 390                 395                 400 


Asn Gly Val Ile Ser Lys Tyr Gly Asn Ile Leu Asp Leu Ala Ser Tyr 
                405                 410                 415     


Gly Ala Met Lys Gln Glu Lys Ala Gln Ser Leu 
            420                 425         


<210>  4
<211>  442
<212>  PRT
<213>  Helicobacter pylori

<400>  4

Met Lys Val Asn Lys Gly Phe Lys Phe Arg Leu Tyr Pro Thr Lys Glu 
1               5                   10                  15      


Gln Gln Asp Lys Leu Gln Arg Cys Phe Phe Val Tyr Asn Gln Ala Tyr 
            20                  25                  30          


Asn Ile Gly Leu Asn Leu Leu Gln Glu Gln Tyr Glu Thr Asn Lys Asp 
        35                  40                  45              


Ser Pro Pro Lys Glu Arg Lys Trp Lys Lys Ser Ser Glu Leu Asp Lys 
    50                  55                  60                  


Ala Ile Lys His His Leu Asn Ala Arg Gly Leu Ser Phe Ser Ser Val 
65                  70                  75                  80  


Ile Ala Gln Gln Ser Arg Met Asn Val Glu Arg Ala Leu Lys Asp Ala 
                85                  90                  95      


Phe Lys Val Lys Asp Arg Gly Phe Pro Lys Phe Lys Asn Ser Lys Ser 
            100                 105                 110         


Ala Lys Gln Ser Phe Ser Trp Asn Asn Gln Gly Phe Ser Ile Lys Asp 
        115                 120                 125             


Ser Asp Glu Glu Arg Phe Lys Ile Phe Thr Leu Met Lys Met Pro Leu 
    130                 135                 140                 


Met Met Arg Met His Arg Asp Phe Pro Pro His Ser Lys Val Lys Gln 
145                 150                 155                 160 


Ile Val Ile Ser Trp Ser His Arg Lys Tyr Phe Val Ser Phe Cys Val 
                165                 170                 175     


Glu Tyr Glu Gln Asp Ile Thr Pro Ile Lys Asn Pro Lys Asn Gly Val 
            180                 185                 190         


Gly Leu Asp Leu Asn Ile Leu Asp Ile Ala Cys Ser Cys Gly Val Asn 
        195                 200                 205             


Asn His Lys Lys Leu Thr Asp Phe Lys Gln Tyr Pro Thr Asp Met Lys 
    210                 215                 220                 


Glu Leu Leu Gly Ile Glu Ile Asp Glu Glu Leu Asp Thr Lys Arg Leu 
225                 230                 235                 240 


Ile Pro Thr Tyr Ser Lys Leu Tyr Ser Leu Lys Lys Tyr Ser Lys Lys 
                245                 250                 255     


Phe Lys Arg Leu Gln Arg Lys Gln Ser Arg Arg Val Leu Lys Ser Lys 
            260                 265                 270         


Gln Asn Lys Thr Lys Leu Gly Gly Asn Phe Tyr Lys Thr Gln Lys Lys 
        275                 280                 285             


Leu Asn Gln Ala Phe Asp Lys Ser Ser His Gln Lys Thr Asp Arg Tyr 
    290                 295                 300                 


His Lys Ile Thr Ser Glu Leu Ser Lys Gln Phe Glu Leu Val Val Val 
305                 310                 315                 320 


Glu Asp Leu Gln Val Lys Asn Met Thr Lys Arg Ala Lys Leu Lys Asn 
                325                 330                 335     


Val Lys Gln Lys Ser Gly Leu Asn Gln Ser Ile Leu Asn Thr Ser Phe 
            340                 345                 350         


Tyr Gln Ile Ile Ser Phe Leu Asp Tyr Lys Gln Gln His Asn Gly Lys 
        355                 360                 365             


Leu Leu Val Lys Val Pro Pro Gln Tyr Thr Ser Lys Thr Cys His Cys 
    370                 375                 380                 


Cys Gly Asn Ile Asn His Lys Leu Lys Leu Asn His Arg Gln Tyr Trp 
385                 390                 395                 400 


Cys Leu Glu Cys Gly Tyr Arg Glu His Arg Asp Ile Asn Ala Ala Asn 
                405                 410                 415     


Asn Ile Ile Ser Lys Gly Leu Ser Leu Phe Gly Val Gly Asn Ile His 
            420                 425                 430         


Ala Asp Phe Lys Glu Gln Ser Leu Ser Cys 
        435                 440         


<210>  5
<211>  402
<212>  PRT
<213>  Escherichia coli

<400>  5

Met Lys Arg Leu Gln Ala Phe Lys Phe Gln Leu Arg Pro Gly Gly Gln 
1               5                   10                  15      


Gln Glu Arg Glu Met Arg Arg Phe Ala Gly Ala Cys Arg Phe Val Phe 
            20                  25                  30          


Asn Arg Ala Leu Ala Leu Gln Asn Glu Asn His Glu Ala Gly Asn Lys 
        35                  40                  45              


Tyr Ile Pro Tyr Gly Lys Met Ala Ser Trp Leu Val Glu Trp Lys Asn 
    50                  55                  60                  


Ala Thr Glu Thr Gln Trp Leu Lys Asp Ala Pro Ser Gln Pro Leu Gln 
65                  70                  75                  80  


Gln Ser Leu Lys Asp Leu Glu Arg Ala Tyr Lys Asn Phe Phe Arg Lys 
                85                  90                  95      


Arg Ala Ala Phe Pro Arg Phe Lys Lys Arg Gly Gln Asn Asp Ala Phe 
            100                 105                 110         


Arg Tyr Pro Gln Gly Val Lys Leu Asp Gln Glu Asn Ser Arg Ile Phe 
        115                 120                 125             


Leu Pro Lys Leu Gly Trp Met Arg Tyr Arg Asn Ser Arg Gln Val Thr 
    130                 135                 140                 


Gly Val Val Lys Asn Val Thr Ala Ser Gln Ser Cys Gly Lys Trp Tyr 
145                 150                 155                 160 


Ile Ser Ile Gln Thr Glu Asn Glu Val Ser Thr Pro Val His Pro Ser 
                165                 170                 175     


Ala Leu Met Val Gly Leu Asp Ala Gly Val Ala Lys Leu Ala Thr Leu 
            180                 185                 190         


Ser Asp Gly Thr Val Phe Gly Pro Val Asn Ser Phe Gln Lys Asn Gln 
        195                 200                 205             


Lys Thr Leu Ala Arg Leu Gln Arg Gln Leu Ser Arg Lys Val Lys Phe 
    210                 215                 220                 


Ser Asn Asn Trp Gln Lys Gln Lys Arg Lys Ile Gln Arg Leu His Ser 
225                 230                 235                 240 


Cys Ile Ala Asn Ile Cys Arg Asp Tyr Leu His Lys Val Thr Thr Thr 
                245                 250                 255     


Val Ser Lys Asn His Ala Met Ile Val Ile Glu Asp Leu Lys Val Ser 
            260                 265                 270         


Asn Met Ser Lys Ser Ala Ala Gly Thr Val Ser Gln Pro Gly Arg Asn 
        275                 280                 285             


Val Arg Ala Lys Ser Gly Leu Asn Arg Ser Ile Leu Asp Gln Gly Trp 
    290                 295                 300                 


Tyr Glu Met Arg Arg Gln Leu Glu Tyr Lys Gln Leu Trp Arg Gly Gly 
305                 310                 315                 320 


Gln Val Leu Ala Val Pro Pro Ala Tyr Thr Ser Gln Arg Cys Ala Cys 
                325                 330                 335     


Cys Gly His Thr Ala Lys Glu Asn Arg Leu Ser Gln Ser Lys Phe Arg 
            340                 345                 350         


Cys Gln Ala Cys Gly Tyr Thr Ala Asn Ala Asp Val Asn Gly Ala Arg 
        355                 360                 365             


Asn Ile Leu Ala Ala Gly His Ala Val Leu Ala Cys Gly Glu Met Val 
    370                 375                 380                 


Gln Ser Gly Arg Pro Leu Lys Gln Glu Pro Thr Glu Met Ile Gln Ala 
385                 390                 395                 400 


Thr Ala 
        


<210>  6
<211>  369
<212>  PRT
<213>  Thermophilic bacterium

<400>  6

Met Ala Asn Lys Ala Tyr Gln Phe Arg Leu Tyr Pro Thr Lys Glu Gln 
1               5                   10                  15      


Glu Gln Leu Leu Ala Lys Thr Phe Gly Cys Val Arg Phe Val Tyr Asn 
            20                  25                  30          


Lys Met Leu Glu Glu Arg Ile Gln Met Phe Glu Lys Phe Lys Asp Asp 
        35                  40                  45              


Gln Glu Ser Leu Lys Gln Gln Thr Cys Pro Thr Pro Ala Lys Tyr Lys 
    50                  55                  60                  


Lys Glu Phe Pro Trp Leu Lys Glu Val Asp Ser Leu Ala Leu Ala Asn 
65                  70                  75                  80  


Ala Gln Leu Asn Leu Gln Lys Ala Phe Gln His Phe Phe Ser Gly Arg 
                85                  90                  95      


Ala Gly Phe Pro Lys Phe Lys Asn Arg Lys Ala Lys Gln Ser Tyr Thr 
            100                 105                 110         


Thr Asn Met Val Asn Gly Asn Ile Lys Leu Ser Asp Gly Tyr Ile Lys 
        115                 120                 125             


Leu Pro Lys Leu Lys Trp Ile Lys Leu Lys Gln His Arg Glu Ile Pro 
    130                 135                 140                 


Ala His His Ile Ile Lys Ser Cys Thr Ile Thr Lys Thr Lys Thr Gly 
145                 150                 155                 160 


Lys Tyr Tyr Ile Ser Ile Leu Thr Glu Tyr Glu His Gln Pro Ala Pro 
                165                 170                 175     


Lys Glu Val Gln Thr Val Val Gly Leu Asp Phe Ser Met Ser Thr Leu 
            180                 185                 190         


Tyr Val Asp Ser Glu Gly Lys Arg Ala Asn Tyr Pro Arg Phe Tyr Arg 
        195                 200                 205             


Lys Ala Leu Glu Thr Leu Ala Lys Glu Gln Arg Lys Trp Ser Arg Lys 
    210                 215                 220                 


Lys Lys Gly Ser Asn Arg Trp His Lys Gln Arg Leu Lys Val Ala Lys 
225                 230                 235                 240 


Leu His Glu Lys Ile Ala Asn Gln Arg Lys Asp Phe Leu His Lys Glu 
                245                 250                 255     


Ser His Lys Leu Ala Lys Arg Tyr Asp Cys Val Val Ile Glu Asp Leu 
            260                 265                 270         


Asn Met Lys Gly Met Ser Gln Ala Leu His Phe Gly Gln Gly Val His 
        275                 280                 285             


Asp Asn Gly Trp Gly Met Phe Thr Thr Phe Leu Gln Tyr Lys Leu Val 
    290                 295                 300                 


Glu Gln Gly Lys Lys Leu Ile Lys Ile Asp Lys Trp Phe Pro Ser Ser 
305                 310                 315                 320 


Lys Thr Cys Ser Cys Cys Gly Arg Val Lys Glu Ser Leu Ser Leu Ser 
                325                 330                 335     


Glu Arg Thr Phe Arg Cys Glu Cys Gly Phe Glu Ser Asp Arg Asp Val 
            340                 345                 350         


Asn Ala Ala Ile Asn Ile Lys His Glu Gly Met Lys Arg Leu Ala Ile 
        355                 360                 365             


Val 
    


<210>  7
<211>  393
<212>  PRT
<213>  Sulfolobus solfataricus

<400>  7

Met Pro Thr Leu Gly Phe Arg Phe Arg Ala Tyr Thr Asp Glu Gln Thr 
1               5                   10                  15      


Leu Arg Ala Leu Lys Ala Gln Leu Lys Leu Thr Cys Glu Ile Tyr Asn 
            20                  25                  30          


Thr Leu Arg Trp Ala Asp Ile Tyr Phe Tyr Gln Arg Asp Gly Lys Gly 
        35                  40                  45              


Leu Thr Gln Thr Glu Leu Arg Gln Leu Ala Leu Asp Leu Arg Lys Gln 
    50                  55                  60                  


Asp Asp Glu Tyr Lys Gln Leu Tyr Ser Gln Val Val Gln Gln Val Ala 
65                  70                  75                  80  


Asp Arg Tyr Ser Glu Ala Lys Lys Arg Phe Phe Glu Gly Leu Ala Arg 
                85                  90                  95      


Phe Pro Lys Glu Lys Lys Pro His Lys Tyr Tyr Ser Leu Val Tyr Thr 
            100                 105                 110         


Gln Ser Gly Trp Lys Ile Leu His Val Arg Glu Ile Arg Lys Gly Lys 
        115                 120                 125             


Lys Asn Lys Lys Lys Leu Ile Thr Leu Lys Leu Ser Asn Leu Gly Thr 
    130                 135                 140                 


Phe Lys Val Ile Val His Arg Asp Phe Pro Leu Asp Lys Val Lys Arg 
145                 150                 155                 160 


Val Val Val Lys Leu Thr Arg Ser Glu Arg Ile Tyr Ile Thr Phe Val 
                165                 170                 175     


Val Asp His Glu Phe Pro Lys Leu Pro Asn Thr Gly Lys Val Val Ala 
            180                 185                 190         


Ile Asp Val Gly Val Glu Lys Leu Leu Ile Thr Ser Asp Gly Glu Tyr 
        195                 200                 205             


Phe Pro Asn Leu Arg Pro Tyr Glu Lys Ala Leu Trp Lys Val Lys His 
    210                 215                 220                 


Ile His Arg Glu Leu Ser Arg Lys Lys Phe Leu Ser Asn Asn Trp Phe 
225                 230                 235                 240 


Lys Ala Lys Val Lys Leu Ala Arg Ala Tyr Glu His Leu Lys Asn Leu 
                245                 250                 255     


Arg Thr Asp Leu Tyr Met Lys Leu Gly Lys Trp Phe Ala Glu His Tyr 
            260                 265                 270         


Asp Val Val Val Met Glu Gly Ile His Ala Lys Gln Leu Val Gly Lys 
        275                 280                 285             


Ser Leu Arg Ser Leu Arg Arg Arg Leu Ser Asp Val Gly Phe Gly Glu 
    290                 295                 300                 


Leu Arg Gly Val Leu Lys Tyr Gln Leu Glu Lys Tyr Gly Lys Lys Leu 
305                 310                 315                 320 


Ile Leu Val Asn Pro Ala Tyr Thr Ser Lys Thr Cys Ala Arg Cys Gly 
                325                 330                 335     


Tyr Val Lys Asn Asp Leu Ser Leu Ser Asp Arg Val Phe Val Cys Pro 
            340                 345                 350         


Asn Cys Gly Trp Ile Ala Asp Arg Asp Tyr Asn Ala Ser Leu Asn Ile 
        355                 360                 365             


Leu Arg Gly Ser Gly Ser Glu Arg Pro Leu Val Trp Ser Ser Ala Leu 
    370                 375                 380                 


Tyr Gln Tyr Ser Gly Lys Val Gly Leu 
385                 390             


<210>  8
<211>  401
<212>  PRT
<213>  Anabaena sp.

<400>  8

Met Leu Val Phe Glu Thr Lys Leu Glu Gly Thr Asn Glu Gln Tyr Gln 
1               5                   10                  15      


Leu Leu Met Arg Arg Leu Lys Leu Leu Val Leu Ser Asn Ala Cys Leu 
            20                  25                  30          


Arg Thr Trp Ile Gly Gln Pro Asn Ile Gly Arg Tyr Asp Leu Ser Ala 
        35                  40                  45              


Tyr Cys Ala Val Leu Leu Pro Met Lys Thr Phe Arg Ser Leu Pro Asn 
    50                  55                  60                  


Ser Thr Leu Trp Leu Asp Lys Leu Leu Leu Lys Glu Arg Gly Val Gln 
65                  70                  75                  80  


Leu Leu Gly Phe Leu Thr Ile Ala Ser Lys Thr Lys Pro Gly Arg Lys 
                85                  90                  95      


Val Ile His Ala Leu Lys Lys Asn Arg Arg Met Gly Val Leu Ser Ile 
            100                 105                 110         


Lys Leu Ala Ala Gly Ser Leu Val Val Thr Val Ala Tyr Val Thr Phe 
        115                 120                 125             


Ser Asp Gly Phe Lys Ala Gly Thr Phe Lys Leu Trp Gly Thr Arg Asp 
    130                 135                 140                 


Leu His Phe Tyr Gln Leu Lys Gln Phe Lys Arg Val Arg Val Val Arg 
145                 150                 155                 160 


Arg Ala Asp Gly Tyr Tyr Ala Gln Phe Cys Ile Asp Gln Glu Arg Val 
                165                 170                 175     


Glu Arg Arg Glu Pro Thr Leu Lys Thr Ile Gly Leu Asp Val Gly Leu 
            180                 185                 190         


Asn His Phe Leu Thr Asp Ser Glu Gly Asn Thr Val Glu Asn Pro Arg 
        195                 200                 205             


His Leu Arg Lys Ser Glu Lys Ser Leu Lys Arg Leu Gln Arg Arg Leu 
    210                 215                 220                 


Ser Lys Thr Lys Lys Gly Ser Asn Asn Arg Val Lys Ala Arg Asn Arg 
225                 230                 235                 240 


Leu Ser Arg Lys His Leu Lys Val Ser Arg Gln Arg Lys Asp Phe Ala 
                245                 250                 255     


Val Lys Leu Ala Arg Cys Val Val Gln Ser Ser Asp Leu Val Ala Tyr 
            260                 265                 270         


Glu Asp Leu Gln Val Arg Asn Met Val Arg Asn Arg His Leu Ala Lys 
        275                 280                 285             


Ser Ile Ser Asp Ala Ala Trp Thr Gln Phe Arg Gln Trp Val Glu Tyr 
    290                 295                 300                 


Phe Gly Lys Val Phe Gly Val Val Thr Val Ala Val Pro Pro His His 
305                 310                 315                 320 


Thr Ser Gln Asn Cys Ser Asn Cys Gly Glu Val Val Lys Lys Ser Leu 
                325                 330                 335     


Ser Thr Arg Thr His Ala Cys Pro His Cys Gly His Ile Gln Asp Arg 
            340                 345                 350         


Asp Trp Asn Ala Ala Arg Asn Ile Leu Glu Leu Gly Leu Arg Thr Val 
        355                 360                 365             


Gly His Thr Gly Ser Gln Val Ser Gly Asp Ile Asp Leu Cys Leu Gly 
    370                 375                 380                 


Glu Val Thr Pro Pro Asn Lys Ser Ser Arg Gly Lys Arg Lys Pro Lys 
385                 390                 395                 400 


Lys 
    


<210>  9
<211>  376
<212>  PRT
<213>  Escherichia coli

<400>  9

Met Lys Arg Ala Tyr Lys Tyr Arg Phe Tyr Pro Thr Thr Glu Gln Ala 
1               5                   10                  15      


Glu Leu Leu Ala Gln Thr Phe Gly Cys Val Arg Phe Val Tyr Asn Ser 
            20                  25                  30          


Ile Leu Arg Trp Arg Thr Asp Ala Tyr Tyr Glu Arg Lys Glu Lys Ile 
        35                  40                  45              


Gly Tyr Leu Gln Ala Asn Ala Arg Leu Thr Ala Leu Lys Lys Glu Pro 
    50                  55                  60                  


Glu Tyr Ile Trp Leu Asn Asp Val Ser Cys Val Pro Leu Gln Gln Ser 
65                  70                  75                  80  


Leu Arg His Gln Gln Ala Ala Phe Ala Asn Phe Phe Ala Gly Arg Ala 
                85                  90                  95      


Ala Tyr Pro Ala Phe Lys Ser Lys Arg His Lys Gln Val Ala Glu Phe 
            100                 105                 110         


Thr Ala Ser Ala Phe Lys His Arg Asp Gly Glu Leu Tyr Ile Ala Lys 
        115                 120                 125             


Ser Lys Ser Pro Leu Asp Val Arg Trp Ser Arg Glu Leu Pro Ser Ala 
    130                 135                 140                 


Pro Ser Thr Val Thr Ile Ser Arg Asp Ser Ala Gly Arg Tyr Phe Val 
145                 150                 155                 160 


Ser Cys Leu Cys Glu Phe Glu Pro Val Ser Met Pro Val Thr Ala Lys 
                165                 170                 175     


Thr Val Gly Ile Asp Val Gly Leu Lys Asp Leu Phe Val Thr Asp Thr 
            180                 185                 190         


Gly Phe Lys Thr Asp Asn Pro Arg His Thr Ala Lys Tyr Ala Lys Arg 
        195                 200                 205             


Leu Thr Leu Leu Gln Arg Arg Leu Ser Arg Lys Gln Lys Gly Ser Arg 
    210                 215                 220                 


Asn Arg Ile Lys Ala Arg Leu Lys Val Ala Arg Leu His Ala Lys Ile 
225                 230                 235                 240 


Ala Asp Cys Arg Met Asp Asn Leu His Lys Leu Ser Arg Lys Leu Ile 
                245                 250                 255     


Asn Glu Asn Gln Val Val Cys Val Glu Ser Leu Lys Val Lys Asn Met 
            260                 265                 270         


Ile Arg Asn Pro Lys Leu Ser Lys Ala Ile Ala Asp Ala Gly Trp Ser 
        275                 280                 285             


Glu Leu Val Arg Gln Leu Gln Tyr Lys Gly Lys Trp Ala Gly Arg Ser 
    290                 295                 300                 


Val Val Ala Ile Asp Gln Tyr Leu Pro Ser Ser Lys Cys Cys Ser Cys 
305                 310                 315                 320 


Cys Gly Phe Thr Met Gln Lys Met Pro Leu Asn Val Arg Lys Trp His 
                325                 330                 335     


Cys Pro Glu Cys Gly Ala Asp His Asp Arg Asp Ile Asn Ala Ala Arg 
            340                 345                 350         


Asn Ile Lys Ala Ala Gly Leu Ala Val Leu Ala His Gly Glu Pro Val 
        355                 360                 365             


Asn Pro Glu Ser Gln His Ala Ala 
    370                 375     


<210>  10
<211>  393
<212>  PRT
<213>  Thermosynechococcus elongatus

<400>  10

Met Arg Gly Val Glu Lys Ala Phe Ser Tyr Arg Phe Tyr Pro Thr Thr 
1               5                   10                  15      


Glu Gln Glu Ser Leu Leu Arg Lys Thr Leu Gly Cys Val Arg Leu Val 
            20                  25                  30          


Tyr Asn Arg Ala Leu Ala Ala Arg Thr Glu Ala Trp Tyr Glu Arg Lys 
        35                  40                  45              


Glu Arg Leu Asp Tyr Val Gln Thr Ser Ala Leu Leu Thr Gln Trp Lys 
    50                  55                  60                  


Lys Gln Asp Asp Leu Gln Phe Leu Asn Glu Val Ser Cys Val Pro Leu 
65                  70                  75                  80  


Gln Gln Ala Leu Arg His Leu Gln Ser Ala Phe Thr Asn Phe Phe Ala 
                85                  90                  95      


Gly Arg Ala Lys Tyr Pro Asn Phe Lys Lys Lys Arg Asn Gly Gly Ser 
            100                 105                 110         


Ala Glu Phe Thr Lys Ser Ala Phe Arg Trp Lys Asp Gly Lys Val Phe 
        115                 120                 125             


Leu Ala Lys Cys Asn Glu Pro Leu Asn Ile Pro Trp Ser Arg Arg Leu 
    130                 135                 140                 


Pro Asp Gly Val Glu Pro Ser Thr Val Thr Ile Arg Leu Asn Pro Ala 
145                 150                 155                 160 


Gly Gln Trp Tyr Ile Ser Leu Arg Phe Asp Asp Pro Arg Glu Leu Thr 
                165                 170                 175     


Leu Gln Pro Val Asp Pro Ser Val Gly Leu Asp Val Gly Met Ser Ser 
            180                 185                 190         


Leu Ile Thr Leu Ser Thr Gly Glu Lys Ile Ala Asn Pro Lys His Phe 
        195                 200                 205             


Asn Arg Tyr Tyr Lys Arg Leu Arg Lys Ala Gln Arg Ser Leu Ser Arg 
    210                 215                 220                 


Lys Gln Lys Gly Ser Arg Asn Trp Asp Lys Ala Arg Leu Lys Val Ala 
225                 230                 235                 240 


Lys Ile His Gln Lys Ile Ser Asp Ser Arg Lys Asp His Leu His Gln 
                245                 250                 255     


Leu Thr Thr Arg Leu Ile Arg Glu Asn Gln Thr Ile Ile Ile Glu Ser 
            260                 265                 270         


Leu Ala Val Lys Asn Met Val Lys Asn Arg Gln Leu Ala Arg Ser Ile 
        275                 280                 285             


Ser Asp Ala Gly Trp Gly Glu Leu Val Arg Gln Leu Glu Tyr Lys Ala 
    290                 295                 300                 


Gln Trp Tyr Gly Arg Thr Leu Val Lys Ile Asp Arg Trp Phe Pro Ser 
305                 310                 315                 320 


Ser Lys Arg Cys Gly Gln Cys Gly His Ile Val Glu Trp Leu Pro Leu 
                325                 330                 335     


Ser Val Arg Glu Trp Asp Cys Pro Lys Cys Gly Ala His His Asp Arg 
            340                 345                 350         


Asp Ile Asn Ala Ala Gly Asn Ile Leu Ala Val Gly His Thr Val Thr 
        355                 360                 365             


Val Cys Gly Ala Gly Val Arg Pro Asp Arg His Thr Ser Gly Gly Gln 
    370                 375                 380                 


Leu Arg Arg Asn Arg Lys Ser Gln Lys 
385                 390             


<210>  11
<211>  419
<212>  PRT
<213>  Helicobacter pylori

<400>  11

Met Ser Ala Ile Ser Ile Thr His Lys Ile Ala Leu Lys Pro Asn Asn 
1               5                   10                  15      


Lys His Ile Thr Tyr Phe Lys Lys Ala Phe Gly Cys Ala Arg Phe Ala 
            20                  25                  30          


Tyr Asn Trp Gly Leu Ala Lys Trp Lys Glu Asn Tyr Gln Leu Gly Ile 
        35                  40                  45              


Lys Thr Ser His Leu Gln Leu Lys Lys Glu Phe Asn Ala Leu Lys Lys 
    50                  55                  60                  


Ser Gln Phe Asn Phe Val Tyr Glu Val Thr Lys Tyr Ala Thr Gln Gln 
65                  70                  75                  80  


Pro Phe Ile His Leu Asn Leu Ala Phe Asn Lys Phe Phe Arg Asp Leu 
                85                  90                  95      


Glu Lys Gly Leu Val Ser Tyr Pro Lys Phe Lys Lys Lys Arg Glu Phe 
            100                 105                 110         


Gln Gly Ser Phe Tyr Ile Gly Gly Asp Gln Ile Lys Ile Ile Gln Thr 
        115                 120                 125             


Ala Asn Thr Asp Tyr Leu Lys Ile Pro Asn Leu Pro Pro Ile Lys Leu 
    130                 135                 140                 


Thr Glu Lys Leu Arg Phe Gln Gly Lys Ile His Asn Ala Thr Ile Thr 
145                 150                 155                 160 


Gln Lys Gly Asp His Phe Tyr Val Ser Ile Ser Cys Asp Ile Asp Glu 
                165                 170                 175     


Ser Glu Tyr Lys Arg Thr His Lys Leu Gln Glu Ser His Asn Lys Leu 
            180                 185                 190         


Gly Ile Asp Ile Gly Ile Lys Ser Phe Val Ser Leu Ser Asn Gly Leu 
        195                 200                 205             


Asn Ile Tyr Ala Pro Lys Pro Leu Asp Lys Leu Thr Arg Lys Leu Val 
    210                 215                 220                 


Arg Ile Ser Arg Gln Leu Ser Lys Lys Ile His Pro Lys Thr Lys Gly 
225                 230                 235                 240 


Asp Lys Thr Arg Lys Ser Asn Asn Tyr Leu Lys His Ser Lys Lys Leu 
                245                 250                 255     


Thr His Leu His Glu Lys Ile Ala Asn Ile Arg Leu Asp Phe Leu His 
            260                 265                 270         


Lys Leu Thr Ser Ser Leu Ile Arg His Ser Asn Ser Phe Cys Leu Glu 
        275                 280                 285             


Ser Leu Lys Val Lys Asn Met Phe Lys Asn His Arg Leu Ala Lys Ser 
    290                 295                 300                 


Leu Ser Asp Ile Ser Met Ser Val Phe Asn Thr Leu Leu Glu Tyr Lys 
305                 310                 315                 320 


Ala Lys Tyr Ser Asn Lys Glu Ile Leu Arg Ala Asp Thr Tyr Tyr Pro 
                325                 330                 335     


Ser Ser Lys Thr Cys Ser Asn Cys Gln Lys Val Lys Gln Asp Leu Lys 
            340                 345                 350         


Leu Lys Asp Arg Ile Tyr Gln Cys Leu Glu Cys Gly Phe Glu Leu Asp 
        355                 360                 365             


Arg Asp Ile Asn Ala Ala Ile Asn Leu Leu Lys His Leu Val Gly Arg 
    370                 375                 380                 


Val Thr Ala Glu Phe Thr Pro Met Asp Leu Thr Ala Leu Leu Asn Asp 
385                 390                 395                 400 


Leu Ser Asn Asn Arg Leu Ala Thr Ser Lys Val Glu Leu Gly Ile Gln 
                405                 410                 415     


Gln Lys Ser 
            


<210>  12
<211>  393
<212>  PRT
<213>  Thermococcus sibiricus

<400>  12

Met Pro Ser Glu Thr Ile Lys Leu Ala Ser Lys Phe Lys Leu Lys Glu 
1               5                   10                  15      


Thr Pro Glu Gly Leu Asn Glu Leu Phe Ser Thr Tyr Arg Asp Ile Val 
            20                  25                  30          


Asn Phe Leu Ile Thr His Ala Phe Glu Asn Asn Ile Thr Ser Phe Tyr 
        35                  40                  45              


Arg Leu Lys Lys Glu Ile Tyr Lys Ser Leu Arg Lys Glu Tyr Pro Glu 
    50                  55                  60                  


Leu Pro Ser His Tyr Ile Tyr Thr Ala Cys Gln Met Ala Ala Ser Ile 
65                  70                  75                  80  


Tyr Lys Ser Tyr Arg Lys Arg Lys Arg Arg Gly Lys Ala Ser Gly Arg 
                85                  90                  95      


Pro Val Phe Lys Lys Glu Ala Ile Met Leu Asp Asp His Leu Phe Lys 
            100                 105                 110         


Leu Asp Leu Glu Lys Gly Ile Ile Lys Leu Ser Thr Pro Asn Gly Arg 
        115                 120                 125             


Ile Thr Leu Lys Phe Tyr Pro Ala Lys His His Glu Lys Phe Lys Asn 
    130                 135                 140                 


Trp Lys Val Gly Gln Ala Trp Leu Val Arg Thr Pro Lys Gly Val Phe 
145                 150                 155                 160 


Ile Asn Val Val Phe Ser Lys Glu Val Glu Val Lys Glu Pro Glu Asp 
                165                 170                 175     


Phe Val Gly Val Asp Leu Asn Glu Asn Asn Val Thr Leu Ser Leu Ser 
            180                 185                 190         


Asp Gly Glu Phe Val Gln Ile Ile Thr His Glu Lys Glu Ile Arg Thr 
        195                 200                 205             


Gly Tyr Phe Val Lys Arg Arg Lys Ile Gln Lys Lys Val Lys Val Gly 
    210                 215                 220                 


Lys Lys Arg Gln Glu Leu Leu Glu Lys Tyr Gly Glu Arg Glu Arg Asn 
225                 230                 235                 240 


Arg Leu Asn Asp Leu Tyr His Lys Leu Ala Asn Lys Ile Val Glu Leu 
                245                 250                 255     


Ala Glu Lys Tyr Gly Gly Ile Ala Leu Glu Asp Leu Thr Glu Ile Arg 
            260                 265                 270         


Asn Ser Ile Arg Tyr Ser Ala Glu Met Asn Gly Arg Leu His Arg Trp 
        275                 280                 285             


Ser Phe Arg Lys Leu Gln Ser Ile Ile Glu Tyr Lys Ala Lys Leu Lys 
    290                 295                 300                 


Gly Val Glu Val Val Phe Val Asp Pro Ala Tyr Thr Ser Ser Leu Cys 
305                 310                 315                 320 


Pro Val Cys Gly Glu Lys Leu Ser Pro Asn Gly His Arg Val Leu Lys 
                325                 330                 335     


Cys Leu Asn Cys Gly Phe Glu Ala Asp Arg Asp Val Val Gly Ser Trp 
            340                 345                 350         


Asn Val Arg Leu Arg Ala Leu Lys Met Trp Gly Val Ser Val Pro Pro 
        355                 360                 365             


Glu Ser Pro Pro Met Lys Met Gly Gly Gly Lys Ala Ser Arg Gly Asp 
    370                 375                 380                 


Val Tyr Glu Leu Tyr Thr Asn Tyr Gly 
385                 390             


<210>  13
<211>  550
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  13

Met Ile Val Arg Met Arg Ser Cys Ala Gln Ala Ala Lys Val Ala Glu 
1               5                   10                  15      


Ala Thr Gly Gly Val Gln Leu Ala Gly Lys Pro Lys Pro Asp Gly Thr 
            20                  25                  30          


Pro Thr Phe Ser Arg Tyr Val Glu Ile Gly Val Asp Phe Glu Ala His 
        35                  40                  45              


Arg Pro Val Val Glu Ser Val Ser Val Leu Phe Glu Leu Tyr Asp Gly 
    50                  55                  60                  


Asp Ala Asn Ser Tyr Ala Ala Thr Gly Gly Pro Gly Ala Gln Leu Pro 
65                  70                  75                  80  


Ser Gly Trp Met Val Thr Ala Ala Lys Phe Glu Val Glu Trp Pro Ala 
                85                  90                  95      


Asp Pro Gln Arg Ala Gly Leu Val Arg Ser His Phe Gly Ala Arg Arg 
            100                 105                 110         


Lys Ala Phe Asn Trp Gly Leu Ala Gln Val Lys Ala Asp Leu Asp Ala 
        115                 120                 125             


Lys Ala Ala Asp Pro Ala His Glu Ser Val Asp Trp Asp Leu Lys Ser 
    130                 135                 140                 


Leu Arg Trp Ala Trp Asn Arg Ala Lys Asp Asp Val Ala Pro Trp Trp 
145                 150                 155                 160 


Ala Glu Asn Ser Lys Glu Cys Tyr Ser Ser Gly Leu Ala Asp Leu Ala 
                165                 170                 175     


Gln Gly Leu Ala Asn Trp Lys Ala Gly Lys Asn Gly Thr Arg Lys Gly 
            180                 185                 190         


Arg Arg Val Gly Phe Pro Arg Phe Lys Ser Gly Arg Arg Asp Pro Gly 
        195                 200                 205             


Arg Val Arg Phe Thr Thr Gly Thr Met Arg Ile Glu Asp Asp Arg Arg 
    210                 215                 220                 


Thr Ile Thr Val Pro Val Ile Gly Pro Leu Arg Ala Lys Glu Asn Thr 
225                 230                 235                 240 


Arg Arg Val Gln Arg His Leu Val Ser Gly Arg Ala Gln Ile Leu Asn 
                245                 250                 255     


Met Thr Leu Ser Gln Arg Trp Gly Arg Leu Phe Val Ala Val Cys Tyr 
            260                 265                 270         


Ala Leu Arg Thr Pro Thr Thr Arg Ser Pro Leu Thr Gln Pro Thr Val 
        275                 280                 285             


Arg Ala Gly Met Asp Leu Gly Val Arg Thr Leu Ala Thr Val Ala Thr 
    290                 295                 300                 


Leu Asp Thr Ala Thr Gly Glu Gln Thr Ile Ile Glu Tyr Pro Asn Pro 
305                 310                 315                 320 


Ala Pro Leu Lys Ala Thr Leu Val Ala Arg Arg Arg Ala Gly Arg Glu 
                325                 330                 335     


Leu Ser Arg Arg Ile Pro Gly Ser His Gly His Arg Ala Val Lys Ala 
            340                 345                 350         


Lys Leu Ala Arg Leu Asp Arg Arg Cys Val His Leu Arg Arg Glu Ala 
        355                 360                 365             


Ala His Gln Leu Thr Thr Glu Leu Ala Gly Thr Tyr Gly Gln Val Val 
    370                 375                 380                 


Ile Glu Asp Leu Asp Val Ala Ala Met Lys Arg Ser Met Arg Arg Arg 
385                 390                 395                 400 


Ala Phe Arg Arg Ser Val Ser Asp Ala Ala Met Gly Leu Val Ala Pro 
                405                 410                 415     


Gln Leu Ala Tyr Lys Thr Ala Lys Cys Ser Gly Val Leu Thr Val Ala 
            420                 425                 430         


Asp Arg Trp Phe Ala Ser Ser Gln Ile His His Gly Cys Thr Ser Pro 
        435                 440                 445             


Asp Gly Thr Pro Cys Arg Leu Gln Gly Lys Gly Arg Ile Asp Lys His 
    450                 455                 460                 


Leu Leu Cys Pro Val Thr Gly Glu Val Val Asp Arg Asp Arg Asn Ala 
465                 470                 475                 480 


Ala Leu Asn Leu Arg Asp Trp Pro Asp Asn Ala Ser Arg Gly Pro Val 
                485                 490                 495     


Gly Thr Thr Ala Pro Ser Ala Pro Gly Pro Thr Thr Thr Val Gly Thr 
            500                 505                 510         


Gly His Gly Ala Asp Thr Gly Ser Ser Gly Ala Gly Gly Ala Ser Val 
        515                 520                 525             


Arg Pro Arg Pro Arg Arg Ala Gly Arg Gly Glu Ala Lys Thr Gln Thr 
    530                 535                 540                 


Pro Gln Gly Asp Ala Ala 
545                 550 


<210>  14
<211>  440
<212>  PRT
<213>  Bifidobacterium longum

<400>  14

Met Ser Ala Tyr Glu Ala Val Arg Ile Arg Leu Asp Pro Thr Pro Arg 
1               5                   10                  15      


Gln Thr Arg Leu Leu Glu Ser His Ala Gly Gly Ala Arg Phe Ala Tyr 
            20                  25                  30          


Asn Leu Met Leu Ala His Val Arg Arg Gln Ile Ser Leu Gly Glu Lys 
        35                  40                  45              


Pro Asp Trp Thr Leu Tyr Ala Met Arg Arg Trp Trp Asn Glu Trp Lys 
    50                  55                  60                  


Asp Glu Ile Ala Pro Trp Trp Arg Glu Asn Ser Lys Glu Ala Tyr Gly 
65                  70                  75                  80  


Ser Ala Phe Glu Trp Leu Ser Gln Ala Leu Arg Asn Trp Ser Asp Ser 
                85                  90                  95      


Arg Lys Gly Arg Arg Ala Gly Arg Arg Val Gly Trp Pro Lys Tyr Lys 
            100                 105                 110         


Ser Lys Arg Ser Ser Val Pro Arg Phe Ala Tyr Thr Thr Gly Ser Phe 
        115                 120                 125             


Gly Leu Ile Glu Asp Asp Pro Lys Ala Leu Arg Leu Pro Arg Ile Gly 
    130                 135                 140                 


Arg Val His Cys Met Glu Asn Ala Thr Glu Arg Val His Gly Arg Arg 
145                 150                 155                 160 


Ile Val Arg Met Thr Val Ser Arg His Ala Gly Phe Trp Tyr Ala Ala 
                165                 170                 175     


Leu Thr Val Glu Arg Pro Thr Glu Ser Val Pro Ala Lys Asn Arg Lys 
            180                 185                 190         


Arg Lys Asn His Asp Arg Gln Val Gly Val Asp Leu Gly Val Arg Thr 
        195                 200                 205             


Leu Ala Thr Leu Ser Asp Gly Thr Thr Phe Pro Asn Pro Arg Asn Tyr 
    210                 215                 220                 


Val Arg Thr Gln Arg Lys Leu Arg His Ala Gln Gln Ser Leu Ser Arg 
225                 230                 235                 240 


Arg Asp Arg Gly Met Ser His Gly Cys Gly Ser Lys Arg Tyr Asn Arg 
                245                 250                 255     


Ala Leu Glu Arg Val Arg Arg Ile His Ala Arg Ile Ala Ala Gln Arg 
            260                 265                 270         


Ala Asp Asn Ile Gly Lys Leu Thr Thr Trp Leu Ala Asp Asn Tyr Ser 
        275                 280                 285             


Asp Ile Ser Ile Glu Asp Leu Asn Val Gln Gly Met Ser His Asn Arg 
    290                 295                 300                 


Arg Leu Ala Lys His Ile Leu Asp Ala Asp Phe His Glu Phe Arg Arg 
305                 310                 315                 320 


Gln Leu Glu Tyr Lys Thr Ala Arg Ala Gly Thr Arg Leu His Val Ile 
                325                 330                 335     


Asp Arg Trp Tyr Pro Ser Ser Lys Thr Cys Ser Asn Cys Gly Thr Val 
            340                 345                 350         


Lys Ala Lys Leu Ser Leu Ser Glu Arg Val Tyr His Cys Glu Glu Cys 
        355                 360                 365             


Gly Leu Val Ile Asp Arg Asp Val Asn Ala Ala Ile Asn Ile Gln Val 
    370                 375                 380                 


Ala Gly Ser Ala Pro Glu Thr Leu Asn Ala Arg Gly Gly Ser Val Gly 
385                 390                 395                 400 


Gln Thr Arg Leu Glu Cys Gly Thr Met Arg His Pro Ala Lys Arg Glu 
                405                 410                 415     


Pro Ser Gly Gly Asp Ser Arg Val Arg Leu Gly Ala Gly Leu Gly Asn 
            420                 425                 430         


Glu Ala Met Gln Met Thr Ser Leu 
        435                 440 


<210>  15
<211>  412
<212>  PRT
<213>  Sulfolobus sp.

<400>  15

Met Glu Arg Thr Ile Lys Leu Arg Val Arg Val Asp Tyr Ile Thr Tyr 
1               5                   10                  15      


Ser Ala Leu Lys Glu Val Glu Gly Glu Tyr Arg Glu Val Leu Glu Asp 
            20                  25                  30          


Ala Ile Asn Tyr Gly Leu Ser Asn Lys Thr Thr Ser Phe Thr Arg Ile 
        35                  40                  45              


Lys Ala Gly Val Tyr Lys Thr Glu Arg Glu Lys His Lys Asp Leu Pro 
    50                  55                  60                  


Ser His Tyr Ile Tyr Thr Ala Cys Glu Asp Ala Ser Glu Arg Leu Asp 
65                  70                  75                  80  


Ser Phe Glu Lys Leu Lys Lys Arg Gly Arg Ser Tyr Thr Glu Lys Pro 
                85                  90                  95      


Ser Val Arg Lys Val Thr Val His Leu Asp Asp His Leu Trp Lys Phe 
            100                 105                 110         


Ser Leu Asp Lys Ile Ser Ile Ser Thr Met Gln Gly Arg Val Phe Ile 
        115                 120                 125             


Ser Pro Thr Phe Pro Lys Ile Phe Trp Arg Tyr Tyr Asn Thr Glu Trp 
    130                 135                 140                 


Arg Ile Ala Ser Glu Ala Arg Phe Lys Leu Leu Lys Gly Asn Val Val 
145                 150                 155                 160 


Glu Phe Phe Ile Val Phe Lys Arg Asp Glu Pro Lys Pro Tyr Glu Pro 
                165                 170                 175     


Lys Gly Phe Ile Pro Val Asp Leu Asn Glu Asp Ser Val Ser Val Leu 
            180                 185                 190         


Val Asp Gly Lys Pro Met Leu Leu Glu Thr Asn Thr Lys Arg Ile Thr 
        195                 200                 205             


Leu Gly Tyr Glu Tyr Arg Arg Lys Ala Ile Thr Thr Arg Arg Ser Ala 
    210                 215                 220                 


Glu Asp Arg Glu Val Lys Arg Lys Leu Lys Arg Leu Arg Glu Arg Asp 
225                 230                 235                 240 


Lys Lys Val Val Ile Arg Arg Lys Leu Ala Lys Leu Ile Val Lys Glu 
                245                 250                 255     


Ala Phe Glu Ser Met Ser Ala Ile Val Leu Glu Ala Leu Pro Arg Arg 
            260                 265                 270         


Pro Pro Glu His Met Ile Lys Asp Val Lys Asp Ser Gln Leu Arg Leu 
        275                 280                 285             


Arg Ile Tyr Arg Ser Ala Phe Ser Ser Met Lys Asn Ala Ile Ile Glu 
    290                 295                 300                 


Lys Ala Lys Glu Phe Arg Val Pro Val Val Leu Val Asn Pro Ser Tyr 
305                 310                 315                 320 


Thr Ser Ser Thr Cys Pro Ile His Gly Ala Lys Ile Val Tyr Gln Pro 
                325                 330                 335     


Asp Gly Gly Asp Ala Pro Arg Val Gly Val Cys Glu Lys Gly Lys Glu 
            340                 345                 350         


Lys Trp His Arg Asp Val Val Ala Leu Tyr Asn Leu Arg Lys Arg Ala 
        355                 360                 365             


Gly Asp Val Ser Pro Val Pro Leu Gly Ser Lys Glu Ser His Asp Pro 
    370                 375                 380                 


Pro Thr Val Lys Leu Gly Arg Trp Leu Arg Ala Lys Ser Leu His Ser 
385                 390                 395                 400 


Ile Met Asn Glu His Lys Met Ile Glu Met Lys Val 
                405                 410         


<210>  16
<211>  32
<212>  RNA
<213>  Deinococcus radiodurans

<400>  16
gaaucacgcg acuuuagucg ugugagguuc aa                                     32


<210>  17
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Target sequence

<400>  17
gggcgccaag ggactc                                                       16


<210>  18
<211>  7
<212>  PRT
<213>  Simian virus 40

<400>  18

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  19
<211>  15
<212>  PRT
<213>  Xenopus sp.

<400>  19

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys 
1               5                   10                  15  


