                         SEQUENCE LISTING

<110>  Ecole Polytechnique Federale de Lausanne (EPFL)
 
<120>  Recombinant bacteria resistant to horizontal gene transfer       
        and phage infection

<130>  epf101wo

<150>  EP21183501
<151>  2021-07-02

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  1190
<212>  PRT
<213>  Vibrio cholerae

<400>  1

Met Asn Val Ser Ile Glu Glu Phe Thr His Phe Asp Phe Gln Leu Val 
1               5                   10                  15      


Pro Glu Pro Ser Pro Leu Asp Leu Val Ile Thr Glu Pro Leu Lys Asn 
            20                  25                  30          


His Ile Glu Val Asn Gly Val Lys Ser Gly Ala Leu Leu Pro Leu Pro 
        35                  40                  45              


Phe Gln Thr Gly Ile Gly Lys Thr Tyr Thr Ala Leu Asn Phe Leu Leu 
    50                  55                  60                  


Gln Gln Met Leu Glu Gln Val Arg Ser Glu Leu Lys Glu Glu Asn Thr 
65                  70                  75                  80  


Gly Lys Lys Ser Lys Arg Leu Leu Tyr Tyr Val Thr Asp Ser Val Asp 
                85                  90                  95      


Asn Val Val Ser Ala Lys Ala Asp Leu Leu Lys Leu Ile Glu Lys Gln 
            100                 105                 110         


Thr Val Lys Gly Glu Pro Arg Phe Thr Leu Glu Gln Gln Glu Tyr Leu 
        115                 120                 125             


Lys Ala Gln Ile Val His Leu Pro Asn Gln Ser Glu Gln Leu Leu Gln 
    130                 135                 140                 


Cys Ser Asp Ala Val Leu Asn Asp Val Leu Ile Gly Phe Asn Leu Asn 
145                 150                 155                 160 


Ala Glu Arg Asp Val Gln Ala Glu Trp Ser Ala Ile Ser Gly Leu Arg 
                165                 170                 175     


Arg His Ala Ser Asn Pro Glu Val Lys Ile Ser Leu Asn Arg Gln Ala 
            180                 185                 190         


Gly Tyr Phe Tyr Arg Asn Leu Ile Asp Arg Leu Gln Lys Lys Gln Lys 
        195                 200                 205             


Gly Ala Asp Arg Val Leu Leu Ser Gly Ser Leu Leu Ala Ser Val Glu 
    210                 215                 220                 


Thr Leu Leu Pro Gly Glu Lys Ile Arg Asn Gly Ser Ala His Val Ala 
225                 230                 235                 240 


Phe Leu Thr Thr Ser Lys Phe Leu Lys Gly Phe His Asn Thr Arg Ser 
                245                 250                 255     


Arg Tyr Ser Pro Leu Arg Asp Leu Ser Gly Ala Val Leu Ile Ile Asp 
            260                 265                 270         


Glu Ile Asp Lys Gln Asn Gln Val Ile Leu Ser Glu Leu Cys Lys Gln 
        275                 280                 285             


Gln Ala Gln Asp Leu Ile Trp Ala Ile Arg Thr Leu Arg Ala Asn Phe 
    290                 295                 300                 


Arg Asp His Gln Leu Glu Ser Ser Pro Arg Tyr Asp Lys Ile Glu Asp 
305                 310                 315                 320 


Leu Phe Glu Pro Leu Arg Glu Arg Leu Glu Glu Phe Gly Thr Asn Trp 
                325                 330                 335     


Asn Leu Ala Phe Ala Phe Asn Thr Glu Gly Ala Asn Leu Asn Glu Arg 
            340                 345                 350         


Pro Val Arg Leu Phe Ser Asp Arg Ser Phe Thr His Val Ser Ser Ala 
        355                 360                 365             


Thr His Lys Leu Ser Leu Lys Ser Asp Phe Leu Arg Arg Lys Asn Leu 
    370                 375                 380                 


Ile Phe Ser Asp Glu Lys Val Glu Gly Ser Leu Ile Glu Lys His Gly 
385                 390                 395                 400 


Leu Leu Thr Arg Phe Val Asn Glu Ala Asp Val Ile Tyr Gln Trp Phe 
                405                 410                 415     


Leu Gly Thr Met Arg Lys Ala Val Phe Gln Tyr Trp Glu Asn Val Arg 
            420                 425                 430         


Gly Leu Glu Ile Glu Val Arg Glu Asn Arg Ser Leu Glu Gly Thr Phe 
        435                 440                 445             


Gln Glu Ala Val Gln Ser Leu Leu Thr His Phe Asn Leu Gln Glu Phe 
    450                 455                 460                 


Glu Ser Ala Val Tyr Glu Ser Phe Asp Thr Arg Gly Leu Arg Gln Ser 
465                 470                 475                 480 


Ala Gly Gly Lys Ala Asn Lys Leu Ser Ser Ser Lys Ser Tyr His His 
                485                 490                 495     


Thr Gly Leu Lys Leu Val Glu Val Ala His Asn Gln Gly Thr Arg Asp 
            500                 505                 510         


Thr Val Asn Cys Lys Ala Ser Phe Leu Asn Thr Ser Pro Ser Gly Val 
        515                 520                 525             


Leu Ala Asp Met Val Asp Ala Gly Ala Val Ile Leu Gly Ile Ser Ala 
    530                 535                 540                 


Thr Ala Arg Ala Asp Thr Val Ile His Asn Phe Asp Phe Lys Tyr Leu 
545                 550                 555                 560 


Asn Glu Arg Leu Gly Asn Lys Leu Leu Ser Leu Ser Arg Glu Gln Lys 
                565                 570                 575     


Gln Arg Val Asn Asn Tyr Tyr His Ser Arg Arg Asn Tyr Lys Asp Asn 
            580                 585                 590         


Gly Val Val Leu Thr Val Lys Tyr Leu Asn Ser Arg Asp Ala Phe Leu 
        595                 600                 605             


Asp Ala Leu Leu Glu Glu Tyr Lys Pro Glu Ala Arg Ser Ser His Phe 
    610                 615                 620                 


Ile Leu Asn His Tyr Leu Gly Ile Ala Glu Ser Glu Gln Ala Phe Val 
625                 630                 635                 640 


Arg Ser Trp Leu Ser Lys Leu Leu Ala Ser Ile Lys Ala Phe Ile Ser 
                645                 650                 655     


Ser Pro Asp Asn Arg Tyr Met Leu Ser Leu Leu Asn Arg Thr Leu Asp 
            660                 665                 670         


Thr Thr Arg Gln Asn Ile Asn Asp Phe Ile Gln Phe Cys Cys Asp Lys 
        675                 680                 685             


Trp Ala Lys Glu Phe Asn Val Lys Thr Lys Thr Phe Phe Gly Val Asn 
    690                 695                 700                 


Ala Asp Trp Met Arg Leu Val Gly Tyr Asp Glu Ile Ser Lys His Leu 
705                 710                 715                 720 


Asn Thr Glu Leu Gly Lys Val Val Val Phe Ser Thr Tyr Ala Ser Met 
                725                 730                 735     


Gly Ala Gly Lys Asn Pro Asp Tyr Ala Val Asn Leu Ala Leu Glu Gly 
            740                 745                 750         


Glu Ser Leu Ile Ser Val Ala Asp Val Thr Tyr Ser Thr Gln Leu Arg 
        755                 760                 765             


Ser Asp Ile Asp Ser Ile Tyr Leu Glu Lys Pro Thr Gln Leu Leu Leu 
    770                 775                 780                 


Ser Asp Asp Tyr Ser His Thr Ala Asn Gln Leu Cys Gln Phe His Gln 
785                 790                 795                 800 


Ile Leu Ser Leu Gln Glu Asn Gly Glu Leu Ser Pro Lys Ser Ala Glu 
                805                 810                 815     


Asn Trp Cys Arg Gln Gln Leu Met Gly Met Ser Arg Glu Arg Ser Leu 
            820                 825                 830         


Gln Gln Tyr His Gln Thr Ser Asp Tyr Gln Ser Ala Val Arg Lys Tyr 
        835                 840                 845             


Ile Glu Gln Ala Val Gly Arg Ala Gly Arg Thr Ser Leu Lys Arg Lys 
    850                 855                 860                 


Gln Ile Leu Leu Phe Val Asp Ser Gly Leu Lys Glu Ile Leu Ala Glu 
865                 870                 875                 880 


Glu Ser Arg Asp Pro Ser Leu Phe Ser His Glu Tyr Val Ala Leu Val 
                885                 890                 895     


Asn Lys Ala Lys Ser Ala Gly Lys Ser Ile Val Glu Asp Arg Ala Val 
            900                 905                 910         


Arg Arg Leu Phe Asn Leu Ala Gln Arg Asn Asn Lys Asp Gly Met Leu 
        915                 920                 925             


Ser Ile Lys Ala Leu Val His Arg Leu His Asn Gln Pro Ala Ser Lys 
    930                 935                 940                 


Ser Asp Ile Gln Glu Trp Gln Asp Ile Arg Thr Gln Leu Leu Arg Tyr 
945                 950                 955                 960 


Pro Thr Val Ala Phe Gln Pro Glu Arg Phe Asn Arg Leu Tyr Leu Gln 
                965                 970                 975     


Ser Met Thr Lys Gly Tyr Tyr Arg Tyr Gln Gly Asn Leu Asp Gly Asp 
            980                 985                 990         


Pro Asn Ser Phe Glu Phe Phe Asp  Arg Val Pro Tyr Gly  Asp Met Val 
        995                 1000                 1005             


Ser Glu  Glu Asp Cys Ser Leu  Ala Thr Leu Val Gln  Asn Gln Tyr 
    1010                 1015                 1020             


Val Arg  Pro Trp Phe Glu Arg  Lys Gly Phe Ala Cys  Ser Trp Gln 
    1025                 1030                 1035             


Lys Glu  Ala Asn Val Met Thr  Pro Ile Met Phe Thr  Asn Ile Tyr 
    1040                 1045                 1050             


Lys Gly  Ala Leu Gly Glu Gln  Ala Val Glu Ala Val  Leu Thr Ala 
    1055                 1060                 1065             


Phe Asp  Phe Thr Phe Glu Glu  Val Pro Asn Ser Ile  Tyr Glu Arg 
    1070                 1075                 1080             


Phe Asp  Asn Arg Val Ile Phe  Ala Gly Ile Glu Gln  Pro Ile Trp 
    1085                 1090                 1095             


Leu Asp  Ser Lys Tyr Trp Lys  His Glu Gly Asn Glu  Ser Ser Glu 
    1100                 1105                 1110             


Gly Tyr  Ser Ser Lys Ile Ala  Leu Val Glu Glu Glu  Phe Gly Pro 
    1115                 1120                 1125             


Ser Lys  Phe Ile Tyr Val Asn  Ala Leu Gly Asp Thr  Ser Lys Pro 
    1130                 1135                 1140             


Ile Arg  Tyr Leu Asn Ser Cys  Phe Val Glu Thr Ser  Pro Gln Leu 
    1145                 1150                 1155             


Ala Lys  Val Ile Glu Ile Pro  Ala Leu Ile Asp Asp  Ser Asn Ala 
    1160                 1165                 1170             


Asp Thr  Asn Arg Thr Ala Val  Gln Glu Leu Ile Lys  Trp Leu His 
    1175                 1180                 1185             


His Ser  
    1190 


<210>  2
<211>  687
<212>  PRT
<213>  Vibrio cholerae

<400>  2

Met Val Thr Pro Gln Leu Glu Pro Ser Ser Gln Gly Pro Leu Ser Thr 
1               5                   10                  15      


Leu Ile Glu Gln Ile Ser Ile Asp Thr Asp Trp Val Asp Arg Ser Phe 
            20                  25                  30          


Ala Ile Tyr Cys Val Ser Tyr Lys Gly Ile Asp Phe Ser Glu Arg Pro 
        35                  40                  45              


Lys Arg Leu Val Thr Leu Ala Ser Glu Thr Tyr Lys Ser Gly Ser Val 
    50                  55                  60                  


Tyr Cys Leu Val Lys Gly Ala Asn Lys Glu Ala Cys Tyr Trp Val Leu 
65                  70                  75                  80  


Leu Pro Lys Asp Ser Lys Leu Asp Leu Lys Asp Thr Ser Leu Ala Ile 
                85                  90                  95      


Lys Pro Ser Ser Ala Ala Glu Leu Pro Thr Trp Gln Leu Ala Arg Leu 
            100                 105                 110         


Leu Ile Lys Ala Ile Pro Lys Val Leu Ser Gly Thr Met Pro Glu Ile 
        115                 120                 125             


Lys Arg Phe Glu Ser Glu Gly Leu Tyr Tyr Leu Val Lys Ser Lys Lys 
    130                 135                 140                 


Leu Pro Lys Asp His Ser Gly Tyr Glu Leu Thr Thr Val Glu Ile Asp 
145                 150                 155                 160 


Leu Ala Pro Cys Ala Ala Leu Gly Phe Lys Gln Thr Leu Ser Met Gly 
                165                 170                 175     


Thr Lys Thr Phe Ser Pro Leu Ser Trp Phe Thr Leu Glu Asn Gly Glu 
            180                 185                 190         


Val Gln Lys Lys Ala Arg Phe Ala Thr Arg Tyr Gln Leu Asp Asp Val 
        195                 200                 205             


Gly Lys Leu Val Ser Lys Ser Ile Lys Gly Asp Tyr Ile Lys Lys Pro 
    210                 215                 220                 


Leu Tyr Ser Asn Ala Lys Asn Arg Ile Gln Ala Ile Asp Ile Thr Lys 
225                 230                 235                 240 


Glu Ser Tyr Ser Gly Phe Gln Leu Ser Lys Val Gly Ile Leu Glu Gln 
                245                 250                 255     


Phe Met Gln Asp Leu Lys Gln Ala Tyr Gly Asp Ser Val Ser Val Lys 
            260                 265                 270         


Leu Gln Arg Ile Pro Gly Glu Lys His Arg Phe Val Ser Asp Thr Ile 
        275                 280                 285             


Val Lys Asn His Tyr Val Gly Leu Phe Asp Ala Leu Lys Glu His Arg 
    290                 295                 300                 


Leu Val Ile Cys Asp Leu Thr Glu Asn Gln Asp Thr Asp Ala Ala Leu 
305                 310                 315                 320 


Thr Leu Leu His Gly Ile Glu His Leu Asp Ile Asn Ala Glu Ile Ala 
                325                 330                 335     


Glu Val Pro Ile Arg Gly Ala Leu Asn Ile Leu Ile Val Gly Asn Lys 
            340                 345                 350         


Asp Thr Tyr Lys Ser Asp Glu Glu Asp Pro Tyr Gln Val Tyr Arg Lys 
        355                 360                 365             


Lys Tyr Gln Asp Thr Val Phe Gln Ser Cys Tyr Pro Glu Arg Leu Trp 
    370                 375                 380                 


Asn Arg Gln Gly Gln Pro Asn Arg His Val Val Glu Val Leu Leu Lys 
385                 390                 395                 400 


Glu Leu Leu Ile Lys Leu Glu Val His Thr Arg Lys His Leu Ile Glu 
                405                 410                 415     


Tyr Pro Ser Gly Pro Glu Arg Cys Val Tyr Tyr Met Pro Gln Arg Pro 
            420                 425                 430         


Lys Asp Glu Ser Ser Glu Val Arg Asp Glu Pro Trp Pro Val Tyr Ala 
        435                 440                 445             


Ser Lys Leu Val Gly Asp Glu Trp Gln Tyr Thr Gln Ala Thr Gln Glu 
    450                 455                 460                 


Glu Leu Glu Asp Ile Glu Leu Asp Leu Gly Asn Asp Lys Arg His Val 
465                 470                 475                 480 


Phe His Gly Phe Glu Arg Ser Pro Val Ile Tyr Trp Pro Glu Thr Gly 
                485                 490                 495     


Asp Tyr Ala Ile Phe Ile Asp Thr Gly Ile Gln Met Leu Pro Glu Phe 
            500                 505                 510         


Glu Ala Val Ala Glu Arg Leu Arg Glu Leu Lys Glu Gly Arg Ser Gln 
        515                 520                 525             


Asp Val Pro Ile Ala Leu Leu Ala Gln Phe Ile Glu Glu Asn Pro Glu 
    530                 535                 540                 


Ser Lys Val Ile Asn Lys Leu Arg Ala Ile Leu Ser Glu Trp Asp Asp 
545                 550                 555                 560 


Val Ala Pro Leu Pro Phe Asp Glu Phe Ser Thr Ile Ala Tyr Lys Ser 
                565                 570                 575     


Ser Asp Glu Lys Gln Phe Tyr Asp Trp Leu Arg Glu Gln Gly Phe Phe 
            580                 585                 590         


Leu Lys Thr Ser Ile Arg Gly Gln Ser Glu Gly Phe Phe Asn Ala Ser 
        595                 600                 605             


Leu Gly Phe Phe Tyr Asn Arg Glu Gln Gly Met Tyr Phe Ala Gly Gly 
    610                 615                 620                 


Lys Gly Ser Pro Gln Ser Lys Ile Glu Thr Phe Ser His Leu Tyr Leu 
625                 630                 635                 640 


Ile Lys His Ser Phe Asp Ala Leu Pro Glu Glu Val Glu Asn Leu Phe 
                645                 650                 655     


Asp Val Tyr His Leu Arg His Arg Leu Pro Thr Val Thr Pro Tyr Pro 
            660                 665                 670         


Phe Lys His Leu Arg Glu Tyr Val Glu Met Gln Arg Phe Arg Ser 
        675                 680                 685         


<210>  3
<211>  388
<212>  PRT
<213>  Vibrio cholerae

<400>  3

Met Lys Asp Asn Ser Thr Ser Ala Val Ser Ser Trp Leu Gly Tyr Lys 
1               5                   10                  15      


Ile Gln Glu Tyr Arg Leu Thr Gln Arg Leu Leu Glu Ala Asn Asn Ser 
            20                  25                  30          


Ser Cys Ile Gly Phe Glu Ile Leu Asp Asp Leu Glu Glu His Thr Gly 
        35                  40                  45              


Ser Thr Ser Thr Phe Glu Gln Asp Lys Ile Ser Thr Thr Gly Arg Asn 
    50                  55                  60                  


Ile Val Ser Asn His Ser Lys Asp Leu Trp Lys Thr Leu Ser Asn Trp 
65                  70                  75                  80  


Met Asp Leu Ile Asp Ser Gly Glu Ile Asp Val Asp Asn Thr Ile Phe 
                85                  90                  95      


Leu Leu Phe Thr Asn Lys Arg Cys His Ser Glu Val Leu Gln Leu Leu 
            100                 105                 110         


Ser Thr Ser Gln Ala Thr Glu Glu Ala Ser Lys Ala Phe Asp Glu Ile 
        115                 120                 125             


Leu Lys Ile Val Ser His Pro Ser Pro Ser Ile Ala Asn Tyr Leu Asn 
    130                 135                 140                 


Asn Phe Ser Lys Ser Lys Thr Asp Ala Cys Arg Leu Ile Ser Lys Phe 
145                 150                 155                 160 


Thr Tyr Ile Tyr Gly Ser Gly Ser Ala Pro His Asp Leu Arg Glu Ser 
                165                 170                 175     


Tyr Lys Leu His Arg Leu Gly Ala Leu Glu Glu His Leu Asp Glu Ile 
            180                 185                 190         


Met Tyr Glu Ile Leu Gly Trp Val Ser Asp Val Leu Thr Leu Ala Ala 
        195                 200                 205             


Glu Lys Arg Gln Pro Thr Ile Val Arg Ala Lys Asp Phe Gly Ala Arg 
    210                 215                 220                 


Leu Gly Glu Ile Glu Ser Lys Tyr Arg Gln Lys Thr Ile Leu Asn Tyr 
225                 230                 235                 240 


Phe Cys Asn Arg Ser Ser Glu Ser Glu Asp Val Gln Asn Thr Ile Lys 
                245                 250                 255     


Asp Ala Pro Asn Tyr Ile Lys Gln Leu Asn Leu Ile Asn Val Asp Asp 
            260                 265                 270         


Ser Glu Leu Glu Glu Ala Ala Ile Ala Asn Leu Glu Thr Lys Asp Ala 
        275                 280                 285             


Val Val Glu Trp Thr Leu Asn Gly Asp Val Gln Asp Tyr Ser Tyr Arg 
    290                 295                 300                 


Tyr Tyr Gln Arg Glu Leu Arg Arg Cys Trp Gly Ile Gln Lys Gln Lys 
305                 310                 315                 320 


Ile His Leu Asp Phe Asn Gly Arg Pro Glu Thr Glu Val Gly Gln Arg 
                325                 330                 335     


Leu Tyr Ile Glu Cys Leu Asn Asn Val Thr Arg Tyr Tyr Leu Glu Asn 
            340                 345                 350         


Lys Lys Val Gly Asp Phe Phe Ala His Gly Thr Leu His Ser Met Ala 
        355                 360                 365             


Asp Lys Leu Thr Ile Gly Trp His Pro Glu Phe Asp Lys Lys Leu Gly 
    370                 375                 380                 


Asp Pro Asp Ala 
385             


<210>  4
<211>  170
<212>  PRT
<213>  Vibrio cholerae

<400>  4

Met Leu Lys Pro Glu Asn Asn Leu Glu Lys Glu Ala Trp Glu Ile Asn 
1               5                   10                  15      


Asn Pro Ala Met Cys Ser Tyr Met Leu Trp Ile Ala Thr Leu Ala Tyr 
            20                  25                  30          


Tyr Gln Lys Gln Lys Glu Pro Ile His Pro Ser Arg Leu Phe Cys Leu 
        35                  40                  45              


Phe Pro Phe Ile Leu Tyr Ser Asp Thr Arg Asn Val Leu Leu Ser Ser 
    50                  55                  60                  


Lys Gly Ser Leu Lys Ser Tyr Leu Ala Lys Phe Ser Asn Ser Lys Ala 
65                  70                  75                  80  


Ile Ser Gly Asp Ile Pro Leu Ser Ile His Phe Arg Ile Asp Ile Gln 
                85                  90                  95      


Lys Asn Lys Thr Leu Asp Ala Leu Ile Val Ala Phe Asp Ser Gly Leu 
            100                 105                 110         


Leu Val Ile Asp Ser Asp Ser Gly Leu Ile Lys Pro Asn Val Ser Ile 
        115                 120                 125             


Lys Pro Leu Pro Asn Ser Lys Leu Thr Asp Thr Ile Lys Glu Leu Val 
    130                 135                 140                 


Tyr Cys Ser Thr Lys Ile Gly Arg Trp Leu Ser Glu Met Thr Asn Gln 
145                 150                 155                 160 


Asp Leu Ala Arg Asp Leu Lys Val Ile Phe 
                165                 170 


<210>  5
<211>  653
<212>  PRT
<213>  Vibrio cholerae

<400>  5

Met Phe Phe Gln Ile Glu Lys Val Val Leu Trp Ser Lys Glu Ala Lys 
1               5                   10                  15      


His Lys Pro Arg Val Ile Glu Phe Ala Leu Asn Lys Val Asn Leu Ile 
            20                  25                  30          


Thr Gly Ser Ser Lys Ser Gly Lys Ser Ser Leu Ile Pro Ile Ile Asp 
        35                  40                  45              


Tyr Cys Leu Gly Ser Ser Lys Cys Ser Ile Pro Val Asn Thr Ile Arg 
    50                  55                  60                  


Asp Thr Thr Ala Trp Tyr Gly Val Gln Ile Lys Thr Lys His Ser Arg 
65                  70                  75                  80  


Leu Leu Ile Ala Arg Arg Asp Pro Ser Asn Gln Leu Ser Thr Ser Asn 
                85                  90                  95      


Ala Phe Phe Val Glu Ala Glu Asn Ile Glu Ile Pro Gln Asn Ile Glu 
            100                 105                 110         


Lys His Asn Val Asn Ile Asp Thr Val Lys Asn Arg Leu Asn Glu Ile 
        115                 120                 125             


Ser Gly Val Ser Asn Ile Ser Phe Asp Phe Tyr Asp Thr Gly Arg Ile 
    130                 135                 140                 


Asp Lys Lys Arg Thr Ser Thr Arg Asp Leu Ser Ala Phe Asn Tyr Gln 
145                 150                 155                 160 


Pro Gln Asn Ile Ile Ala Asn Pro Asn Ala Leu Phe Tyr Lys Thr Asp 
                165                 170                 175     


Ser Phe Glu His Lys Ser Lys Leu Val Thr Ile Leu Pro Tyr Val Leu 
            180                 185                 190         


Gly Ala Leu Ser Asn Thr Asp Ile Glu Asn Gln His Arg Ile Lys Asn 
        195                 200                 205             


Leu Glu Glu Glu Tyr Arg Lys Val Glu Arg Arg Leu Leu Lys Leu Lys 
    210                 215                 220                 


Arg Gln Asn Glu Asp Trp Leu Ser Ser Ala Gln Ala Tyr Val Ile Lys 
225                 230                 235                 240 


Ala Met Glu Leu Gly Leu Val Asn Ser Asp Lys Asp Ile Tyr Gln Leu 
                245                 250                 255     


Lys Pro Glu Arg Leu Leu Asn Val Leu Lys Asn Ile Ala Thr Lys Glu 
            260                 265                 270         


Ile Asp Tyr Ser Thr Ser Ala Ala Asn Ile Lys Tyr Ala Ser Glu Gln 
        275                 280                 285             


Glu Ala Glu Ile Thr Lys Arg Ser Arg Asp Ile Ser Asn Asn Leu Ala 
    290                 295                 300                 


Lys Val Lys Ser Arg Leu Gln Asn Ile Asn Ser Met Asn Arg Leu Ala 
305                 310                 315                 320 


Asn Thr His Ser Asp Ala Ser Arg Leu Lys Arg Glu Arg Leu Ser Leu 
                325                 330                 335     


Ser Lys Trp Leu Leu Thr Gln Asn Asp Ile Asn Ser Ser Leu Phe Ser 
            340                 345                 350         


Glu Pro Asn Glu Ile Arg Ser Leu Val Leu Glu Pro Leu Ala Arg Ala 
        355                 360                 365             


Phe Ser Asn Leu Glu Ala Glu Leu Glu Val Pro Ile His Val Gln Gly 
    370                 375                 380                 


Ala Leu Ser Arg Glu Lys Ile Tyr Leu Glu Gly Glu Leu Thr Arg Leu 
385                 390                 395                 400 


Ala Ser Glu Met Lys Asp Val Asn Thr Gln Leu Lys Ile Leu Arg Gly 
                405                 410                 415     


Asn Lys Arg Lys Leu Gly Tyr Asp Ala Phe Ser Val Gly Lys Phe Val 
            420                 425                 430         


Gly Glu Val Glu Lys Ala Leu Ser Leu Met Gly Glu Ser Glu Ser Glu 
        435                 440                 445             


Ser Glu Leu Ser Lys Glu Tyr Lys Arg Leu Lys Lys Glu Leu Ser Val 
    450                 455                 460                 


Leu Arg Leu Lys Ile Asp Pro Arg Glu Phe Glu Arg Lys Thr Lys Leu 
465                 470                 475                 480 


Gln Leu Ala Lys Val Asn Lys Leu Ala Ser Asp Trp Leu Pro His Leu 
                485                 490                 495     


Asp Thr Glu Asn Pro Asn Ala Pro Ile Ser Leu His Glu Lys Glu Leu 
            500                 505                 510         


Thr Ile Thr Val Asn Ser Ser Gly Arg Glu Asp Tyr Leu Trp Glu Ile 
        515                 520                 525             


Gly Ser Gly Ala Asn Trp Leu Ser Tyr His Val Ala Ile Thr Leu Ala 
    530                 535                 540                 


Leu His Gln His Phe Ser Ser Leu Glu Ala Ser Pro Val Pro Asn Tyr 
545                 550                 555                 560 


Ile Ile Tyr Asp Gln Pro Ser Gln Val Tyr Phe Pro Ser Lys Leu Arg 
                565                 570                 575     


His Gln Ala Thr Pro Glu Glu Asp Glu Leu Ala Leu Leu Glu Gln Asp 
            580                 585                 590         


Glu Asp Ile Val Gln Val Lys Lys Ile Phe Glu Ala Phe Asn Gly Ala 
        595                 600                 605             


Ile Glu Lys Thr Lys Asp Asn Leu Gln Ile Ile Val Leu Asp His Ala 
    610                 615                 620                 


Pro Ser Thr Leu Val Lys Ser Ile Pro Lys Gly His Leu Val Glu Glu 
625                 630                 635                 640 


Trp Arg Asn Gly Ile Lys Leu Ile Pro Leu Asp Trp Leu 
                645                 650             


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Walker A GxGKT-type motif


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa postion 2 is any amino acid

<400>  6

Gly Xaa Gly Lys Thr 
1               5   


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Walker B h4DExD-type motif


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  Xaa position 1-4 is any hydrophobic amino acid.

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa position 7 is any amino acid

<400>  7

Xaa Xaa Xaa Xaa Asp Glu Xaa Asp 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  arginine finger QxxGRxxR-type motif


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa is any amino acid<220><221>  MISC_FEATURE<222>  (6)..(7)<223>
       Xaa is any amino acid

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  8

Gln Xaa Xaa Gly Arg Xaa Xaa Arg 
1               5               


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclease domain PD-(D/E)xK-type motif


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa position 3 is selected from aspartic acid (D, Asp), or 
       glutamic acid (E, Glu).

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa position 4 is any amino acid

<400>  9

Pro Asp Xaa Xaa Lys 
1               5   


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Walker A Gx4GKS/T-type motif


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Xaa position 2-5 is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa position 8 is selected from serine (S, Ser), or threonine (T,
       Thr).

<400>  10

Gly Xaa Xaa Xaa Xaa Gly Lys Xaa 
1               5               


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUF3732 domain Walker B h4DQ-like motif.


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  Xaa position 1-4 is any hydrophobic amino acid.

<400>  11

Xaa Xaa Xaa Xaa Asp Gln 
1               5       


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PXXXL functional motif


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa position 2-4 is any amino acid

<400>  12

Pro Xaa Xaa Xaa Leu 
1               5   


<210>  13
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEXD functional motif


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa position 3 is any amino acid

<400>  13

Asp Glu Xaa Asp 
1               


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L/VXTXXG/A functional motif


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa position 1 is selected from leucine (L, Leu), or valine (V, 
       Val).

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is any amino acid<220><221>  MISC_FEATURE<222>  (4)..(5)<223>
       Xaa is any amino acid

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa position 6 is selected from glycine (G, Gly), or alanine (A, 
       Ala).

<400>  14

Xaa Xaa Thr Xaa Xaa Xaa 
1               5       


