﻿               SEQUENCE LISTING

<110> Charité-Universitätsmedizin Berlin, DE

<120> System for high-level rAAV production

<130> 13337 P 6821 WO

<160> 22

<170> BiSSAP 1.3.6

<210> 1
<211> 4679
<212> DNA
<213> Adeno-associated virus - 2


<220> 
<223> AAV-2 genome

<220> 
<221> misc_feature
<222> 1..145
<223> /note="left inverted terminal repeat "

<220> 
<221> promoter
<222> 191..320
<223> /note="p5 promoter region "

<220> 
<221> promoter
<222> 287
<223> /note="p5 transcription start site"

<220> 
<221> gene
<222> 321..1906
<223> /gene="rep68 gene"

<220> 
<221> gene
<222> 321..2183
<223> /gene="rep78 gene"

<220> 
<221> promoter
<222> 873
<223> /note="p19 transcription start site"

<220> 
<221> gene
<222> 993..1906
<223> /gene="rep40 gene"

<220> 
<221> gene
<222> 993..2183
<223> /gene="rep52 gene"

<220> 
<221> promoter
<222> 1701..1853
<223> /note="p40 promoter"

<220> 
<221> misc_feature
<222> 1701..2186
<223> /note="RIS-Ad"

<220> 
<221> misc_feature
<222> 1907..1908
<223> /note="splice donor site "

<220> 
<221> misc_feature
<222> 2199..2200
<223> /note="minor splice acceptor site "

<220> 
<221> gene
<222> 2203..4407
<223> /gene="VP open reading frame"

<220> 
<221> gene
<222> 2203..4407
<223> /gene="VP1 gene"

<220> 
<221> misc_feature
<222> 2226..2227
<223> /note="major splice acceptor site"

<220> 
<221> misc_feature
<222> 2228..2249
<223> /note="Rep68/Rep40-s"

<220> 
<221> gene
<222> 2614..4407
<223> /gene="VP2 gene"

<220> 
<221> gene
<222> 2809..4407
<223> /gene="VP3 gene"

<220> 
<221> misc_feature
<222> 4535..4679
<223> /note="right inverted terminal repeat "

<400> 1
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgtatt agaggtcacg tgagtgtttt gcgacatttt gcgacaccat      240

gtggtcacgc tgggtattta agcccgagtg agcacgcagg gtctccattt tgaagcggga      300

ggtttgaacg cgcagccgcc atgccggggt tttacgagat tgtgattaag gtccccagcg      360

accttgacgg gcatctgccc ggcatttctg acagctttgt gaactgggtg gccgagaagg      420

aatgggagtt gccgccagat tctgacatgg atctgaatct gattgagcag gcacccctga      480

ccgtggccga gaagctgcag cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc      540

cggaggccct tttctttgtg caatttgaga agggagagag ctacttccac atgcacgtgc      600

tcgtggaaac caccggggtg aaatccatgg ttttgggacg tttcctgagt cagattcgcg      660

aaaaactgat tcagagaatt taccgcggga tcgagccgac tttgccaaac tggttcgcgg      720

tcacaaagac cagaaatggc gccggaggcg ggaacaaggt ggtggatgag tgctacatcc      780

ccaattactt gctccccaaa acccagcctg agctccagtg ggcgtggact aatatggaac      840

agtatttaag cgcctgtttg aatctcacgg agcgtaaacg gttggtggcg cagcatctga      900

cgcacgtgtc gcagacgcag gagcagaaca aagagaatca gaatcccaat tctgatgcgc      960

cggtgatcag atcaaaaact tcagccaggt acatggagct ggtcgggtgg ctcgtggaca     1020

aggggattac ctcggagaag cagtggatcc aggaggacca ggcctcatac atctccttca     1080

atgcggcctc caactcgcgg tcccaaatca aggctgcctt ggacaatgcg ggaaagatta     1140

tgagcctgac taaaaccgcc cccgactacc tggtgggcca gcagcccgtg gaggacattt     1200

ccagcaatcg gatttataaa attttggaac taaacgggta cgatccccaa tatgcggctt     1260

ccgtctttct gggatgggcc acgaaaaagt tcggcaagag gaacaccatc tggctgtttg     1320

ggcctgcaac taccgggaag accaacatcg cggaggccat agcccacact gtgcccttct     1380

acgggtgcgt aaactggacc aatgagaact ttcccttcaa cgactgtgtc gacaagatgg     1440

tgatctggtg ggaggagggg aagatgaccg ccaaggtcgt ggagtcggcc aaagccattc     1500

tcggaggaag caaggtgcgc gtggaccaga aatgcaagtc ctcggcccag atagacccga     1560

ctcccgtgat cgtcacctcc aacaccaaca tgtgcgccgt gattgacggg aactcaacga     1620

ccttcgaaca ccagcagccg ttgcaagacc ggatgttcaa atttgaactc acccgccgtc     1680

tggatcatga ctttgggaag gtcaccaagc aggaagtcaa agactttttc cggtgggcaa     1740

aggatcacgt ggttgaggtg gagcatgaat tctacgtcaa aaagggtgga gccaagaaaa     1800

gacccgcccc cagtgacgca gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc     1860

agccatcgac gtcagacgcg gaagcttcga tcaactacgc agacaggtac caaaacaaat     1920

gttctcgtca cgtgggcatg aatctgatgc tgtttccctg cagacaatgc gagagaatga     1980

atcagaattc aaatatctgc ttcactcacg gacagaaaga ctgtttagag tgctttcccg     2040

tgtcagaatc tcaacccgtt tctgtcgtca aaaaggcgta tcagaaactg tgctacattc     2100

atcatatcat gggaaaggtg ccagacgctt gcactgcctg cgatctggtc aatgtggatt     2160

tggatgactg catctttgaa caataaatga tttaaatcag gtatggctgc cgatggttat     2220

cttccagatt ggctcgagga cactctctct gaaggaataa gacagtggtg gaagctcaaa     2280

cctggcccac caccaccaaa gcccgcagag cggcataagg acgacagcag gggtcttgtg     2340

cttcctgggt acaagtacct cggacccttc aacggactcg acaagggaga gccggtcaac     2400

gaggcagacg ccgcggccct cgagcacgac aaagcctacg accggcagct cgacagcgga     2460

gacaacccgt acctcaagta caaccacgcc gacgcggagt ttcaggagcg ccttaaagaa     2520

gatacgtctt ttgggggcaa cctcggacga gcagtcttcc aggcgaaaaa gagggttctt     2580

gaacctctgg gcctggttga ggaacctgtt aagacggctc cgggaaaaaa gaggccggta     2640

gagcactctc ctgtggagcc agactcctcc tcgggaaccg gaaaggcggg ccagcagcct     2700

gcaagaaaaa gattgaattt tggtcagact ggagacgcag actcagtacc tgacccccag     2760

cctctcggac agccaccagc agccccctct ggtctgggaa ctaatacgat ggctacaggc     2820

agtggcgcac caatggcaga caataacgag ggcgccgacg gagtgggtaa ttcctcggga     2880

aattggcatt gcgattccac atggatgggc gacagagtca tcaccaccag cacccgaacc     2940

tgggccctgc ccacctacaa caaccacctc tacaaacaaa tttccagcca atcaggagcc     3000

tcgaacgaca atcactactt tggctacagc accccttggg ggtattttga cttcaacaga     3060

ttccactgcc acttttcacc acgtgactgg caaagactca tcaacaacaa ctggggattc     3120

cgacccaaga gactcaactt caagctcttt aacattcaag tcaaagaggt cacgcagaat     3180

gacggtacga cgacgattgc caataacctt accagcacgg ttcaggtgtt tactgactcg     3240

gagtaccagc tcccgtacgt cctcggctcg gcgcatcaag gatgcctccc gccgttccca     3300

gcagacgtct tcatggtgcc acagtatgga tacctcaccc tgaacaacgg gagtcaggca     3360

gtaggacgct cttcatttta ctgcctggag tactttcctt ctcagatgct gcgtaccgga     3420

aacaacttta ccttcagcta cacttttgag gacgttcctt tccacagcag ctacgctcac     3480

agccagagtc tggaccgtct catgaatcct ctcatcgacc agtacctgta ttacttgagc     3540

agaacaaaca ctccaagtgg aaccaccacg cagtcaaggc ttcagttttc tcaggccgga     3600

gcgagtgaca ttcgggacca gtctaggaac tggcttcctg gaccctgtta ccgccagcag     3660

cgagtatcaa agacatctgc ggataacaac aacagtgaat actcgtggac tggagctacc     3720

aagtaccacc tcaatggcag agactctctg gtgaatccgg gcccggccat ggcaagccac     3780

aaggacgatg aagaaaagtt ttttcctcag agcggggttc tcatctttgg gaagcaaggc     3840

tcagagaaaa caaatgtgga cattgaaaag gtcatgatta cagacgaaga ggaaatcagg     3900

acaaccaatc ccgtggctac ggagcagtat ggttctgtat ctaccaacct ccagagaggc     3960

aacagacaag cagctaccgc agatgtcaac acacaaggcg ttcttccagg catggtctgg     4020

caggacagag atgtgtacct tcaggggccc atctgggcaa agattccaca cacggacgga     4080

cattttcacc cctctcccct catgggtgga ttcggactta aacaccctcc tccacagatt     4140

ctcatcaaga acaccccggt acctgcgaat ccttcgacca ccttcagtgc ggcaaagttt     4200

gcttccttca tcacacagta ctccacggga caggtcagcg tggagatcga gtgggagctg     4260

cagaaggaaa acagcaaacg ctggaatccc gaaattcagt acacttccaa ctacaacaag     4320

tctgttaatg tggactttac tgtggacact aatggcgtgt attcagagcc tcgccccatt     4380

ggcaccagat acctgactcg taatctgtaa ttgcttgtta atcaataaac cgtttaattc     4440

gtttcagttg aactttggtc tctgcgtatt tctttcttat ctagtttcca tggctacgta     4500

gataagtagc atggcgggtt aatcattaac tacaaggaac ccctagtgat ggagttggcc     4560

actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc     4620

ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcagagaggg agtggccaa      4679


<210> 2
<211> 486
<212> DNA
<213> Adeno-associated virus - 2


<220> 
<223> RIS-Ad

<400> 2
gtcaccaagc aggaagtcaa agactttttc cggtgggcaa aggatcacgt ggttgaggtg      60

gagcatgaat tctacgtcaa aaagggtgga gccaagaaaa gacccgcccc cagtgacgca     120

gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc agccatcgac gtcagacgcg     180

gaagcttcga tcaactacgc agacaggtac caaaacaaat gttctcgtca cgtgggcatg     240

aatctgatgc tgtttccctg cagacaatgc gagagaatga atcagaattc aaatatctgc     300

ttcactcacg gacagaaaga ctgtttagag tgctttcccg tgtcagaatc tcaacccgtt     360

tctgtcgtca aaaaggcgta tcagaaactg tgctacattc atcatatcat gggaaaggtg     420

ccagacgctt gcactgcctg cgatctggtc aatgtggatt tggatgactg catctttgaa     480

caataa                                                                486


<210> 3
<211> 486
<212> DNA
<213> Artificial Sequence


<220> 
<223> Recoded RIS-Ad

<400> 3
gtgacgaaac aggaggtgaa ggacttcttt agatgggcca aggaccacgt ggtggaggtc      60

gagcacgagt tttatgtgaa gaaggggggg gccaaaaagc gccctgcacc ttccgacgcc     120

gacatttccg agccaaagag agtgcgtgag agtgtggccc aaccctccac cagtgatgcc     180

gaggcctcca ttaattatgc cgaccgctat cagaataagt gctcaaggca tgtcgggatg     240

aacctgatgc tgttcccatg ccgccagtgc gagcgcatga accagaacag caacatttgt     300

tttacccacg ggcagaagga ttgcctggaa tgcttcccgg tcagcgagtc acagccggtg     360

tccgtggtga agaaagccta ccaaaagctg tgttacatcc accacattat ggggaaagtc     420

cccgatgcct gtaccgcatg cgacctggtg aacgttgacc tcgacgactg cattttcgag     480

cagtaa                                                                486


<210> 4
<211> 135
<212> DNA
<213> Artificial Sequence


<220> 
<223> sRep (recoded AAV-2 nucleotides 1782 to 1916)

<400> 4
aagggggggg ccaaaaagcg ccctgcacct tccgacgccg acatttccga gccaaagaga     60

gtgcgtgaga gtgtggccca accctccacc agtgatgccg aggcctccat taattatgcc    120

gaccgctatc agaat                                                     135


<210> 5
<211> 621
<212> PRT
<213> Adeno-associated virus - 2


<220> 
<223> Rep78 aa sequence

<400> 5
Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      
Gly His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          
Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              
Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  
Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  
Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      
Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         
Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             
Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 
Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 
Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     
Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         
Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             
Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 
Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 
Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     
Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         
Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             
Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 
Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 
Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     
Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         
Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             
Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 
Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 
Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     
Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         
Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             
Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 
Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 
Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     
Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         
Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             
Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 
Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
545                 550                 555                 560 
Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     
Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
            580                 585                 590         
Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
        595                 600                 605             
Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620     

<210> 6
<211> 245
<212> DNA
<213> Herpes simplex virus unknown type


<220> 
<223> HSV-TK promoter

<400> 6
ctgcttcatc cccgtggccc gttgctcgcg tttgctggcg gtgtccccgg aagaaatata     60

tttgcatgtc tttagttcta tgatgacaca aaccccgccc agcgtcttgt cattggcgaa    120

ttcgaacacg cagatgcagt cggggcggcg cggtcccagg tccacttcgc atattaaggt    180

gacgcgtgtg gcctcgaaca ccgagcgacc ctgcagcgac ccgcttaaca gcgtcaacag    240

cgtgc                                                                245


<210> 7
<211> 34946
<212> DNA
<213> Artificial Sequence


<220> 
<223> rep-rAdV nucleic acid sequence

<220> 
<221> misc_feature
<222> 355..27115
<223> /note="Adenovirus type 5 genome, E1 and E3 deleted"

<220> 
<221> variation
<222> 25831

<220> 
<221> misc_feature
<222> 27997..28099
<223> /note="right inverted terminal repeats"

<220> 
<221> rep_origin
<222> 28303..28970
<223> /note="pBR322 origin"

<220> 
<221> gene
<222> 29779..30570
<223> /gene="kanamycin resistance gene"

<220> 
<221> misc_feature
<222> 31038..31140
<223> /note="left inverted terminal repeat"

<220> 
<221> misc_feature
<222> 31220..31368
<223> /note="encapsidation signal"

<220> 
<221> misc_feature
<222> 31408..31539
<223> /note="sRep recoded sequence in C-terminus of sRep-Stop531"

<220> 
<221> gene
<222> 31411..33000
<223> /gene="Rep Stop 531"

<220> 
<221> misc_feature
<222> 32448
<223> /note="Rep Stop 531"

<220> 
<221> TATA_signal
<222> 32472..32478
<223> /note="TATA Box p19 Promoter"

<220> 
<221> promoter
<222> 33010..33254
<223> /note="HSV-TK promoter"

<400> 7
gtcacctgct ctacggcatc tcgatccagc atatctcctc gtttcgcggg ttggggcggc        60

tttcgctgta cggcagtagt cggtgctcgt ccagacgggc cagggtcatg tctttccacg       120

ggcgcagggt cctcgtcagc gtagtctggg tcacggtgaa ggggtgcgct ccgggctgcg       180

cgctggccag ggtgcgcttg aggctggtcc tgctggtgct gaagcgctgc cggtcttcgc       240

cctgcgcgtc ggccaggtag catttgacca tggtgtcata gtccagcccc tccgcggcgt       300

ggcccttggc gcgcagcttg cccttggagg aggcgccgca cgaggggcag tgcagacttt       360

tgagggcgta gagcttgggc gcgagaaata ccgattccgg ggagtaggca tccgcgccgc       420

aggccccgca gacggtctcg cattccacga gccaggtgag ctctggccgt tcggggtcaa       480

aaaccaggtt tcccccatgc tttttgatgc gtttcttacc tctggtttcc atgagccggt       540

gtccacgctc ggtgacgaaa aggctgtccg tgtccccgta tacagacttg agaggcctgt       600

cctcgagcgg tgttccgcgg tcctcctcgt atagaaactc ggaccactct gagacaaagg       660

ctcgcgtcca ggccagcacg aaggaggcta agtgggaggg gtagcggtcg ttgtccacta       720

gggggtccac tcgctccagg gtgtgaagac acatgtcgcc ctcttcggca tcaaggaagg       780

tgattggttt gtaggtgtag gccacgtgac cgggtgttcc tgaagggggg ctataaaagg       840

gggtgggggc gcgttcgtcc tcactctctt ccgcatcgct gtctgcgagg gccagctgtt       900

ggggtgagta ctccctctga aaagcgggca tgacttctgc gctaagattg tcagtttcca       960

aaaacgagga ggatttgata ttcacctggc ccgcggtgat gcctttgagg gtggccgcat      1020

ccatctggtc agaaaagaca atctttttgt tgtcaagctt ggtggcaaac gacccgtaga      1080

gggcgttgga cagcaacttg gcgatggagc gcagggtttg gtttttgtcg cgatcggcgc      1140

gctccttggc cgcgatgttt agctgcacgt attcgcgcgc aacgcaccgc cattcgggaa      1200

agacggtggt gcgctcgtcg ggcaccaggt gcacgcgcca accgcggttg tgcagggtga      1260

caaggtcaac gctggtggct acctctccgc gtaggcgctc gttggtccag cagaggcggc      1320

cgcccttgcg cgagcagaat ggcggtaggg ggtctagctg cgtctcgtcc ggggggtctg      1380

cgtccacggt aaagaccccg ggcagcaggc gcgcgtcgaa gtagtctatc ttgcatcctt      1440

gcaagtctag cgcctgctgc catgcgcggg cggcaagcgc gcgctcgtat gggttgagtg      1500

ggggacccca tggcatgggg tgggtgagcg cggaggcgta catgccgcaa atgtcgtaaa      1560

cgtagagggg ctctctgagt attccaagat atgtagggta gcatcttcca ccgcggatgc      1620

tggcgcgcac gtaatcgtat agttcgtgcg agggagcgag gaggtcggga ccgaggttgc      1680

tacgggcggg ctgctctgct cggaagacta tctgcctgaa gatggcatgt gagttggatg      1740

atatggttgg acgctggaag acgttgaagc tggcgtctgt gagacctacc gcgtcacgca      1800

cgaaggaggc gtaggagtcg cgcagcttgt tgaccagctc ggcggtgacc tgcacgtcta      1860

gggcgcagta gtccagggtt tccttgatga tgtcatactt atcctgtccc ttttttttcc      1920

acagctcgcg gttgaggaca aactcttcgc ggtctttcca gtactcttgg atcggaaacc      1980

cgtcggcctc cgaacggtaa gagcctagca tgtagaactg gttgacggcc tggtaggcgc      2040

agcatccctt ttctacgggt agcgcgtatg cctgcgcggc cttccggagc gaggtgtggg      2100

tgagcgcaaa ggtgtccctg accatgactt tgaggtactg gtatttgaag tcagtgtcgt      2160

cgcatccgcc ctgctcccag agcaaaaagt ccgtgcgctt tttggaacgc ggatttggca      2220

gggcgaaggt gacatcgttg aagagtatct ttcccgcgcg aggcataaag ttgcgtgtga      2280

tgcggaaggg tcccggcacc tcggaacggt tgttaattac ctgggcggcg agcacgatct      2340

cgtcaaagcc gttgatgttg tggcccacaa tgtaaagttc caagaagcgc gggatgccct      2400

tgatggaagg caatttttta agttcctcgt aggtgagctc ttcaggggag ctgagcccgt      2460

gctctgaaag ggcccagtct gcaagatgag ggttggaagc gacgaatgag ctccacaggt      2520

cacgggccat tagcatttgc aggtggtcgc gaaaggtcct aaactggcga cctatggcca      2580

ttttttctgg ggtgatgcag tagaaggtaa gcgggtcttg ttcccagcgg tcccatccaa      2640

ggttcgcggc taggtctcgc gcggcagtca ctagaggctc atctccgccg aacttcatga      2700

ccagcatgaa gggcacgagc tgcttcccaa aggcccccat ccaagtatag gtctctacat      2760

cgtaggtgac aaagagacgc tcggtgcgag gatgcgagcc gatcgggaag aactggatct      2820

cccgccacca attggaggag tggctattga tgtggtgaaa gtagaagtcc ctgcgacggg      2880

ccgaacactc gtgctggctt ttgtaaaaac gtgcgcagta ctggcagcgg tgcacgggct      2940

gtacatcctg cacgaggttg acctgacgac cgcgcacaag gaagcagagt gggaatttga      3000

gcccctcgcc tggcgggttt ggctggtggt cttctacttc ggctgcttgt ccttgaccgt      3060

ctggctgctc gaggggagtt acggtggatc ggaccaccac gccgcgcgag cccaaagtcc      3120

agatgtccgc gcgcggcggt cggagcttga tgacaacatc gcgcagatgg gagctgtcca      3180

tggtctggag ctcccgcggc gtcaggtcag gcgggagctc ctgcaggttt acctcgcata      3240

gacgggtcag ggcgcgggct agatccaggt gatacctaat ttccaggggc tggttggtgg      3300

cggcgtcgat ggcttgcaag aggccgcatc cccgcggcgc gactacggta ccgcgcggcg      3360

ggcggtgggc cgcgggggtg tccttggatg atgcatctaa aagcggtgac gcgggcgagc      3420

ccccggaggt agggggggct ccggacccgc cgggagaggg ggcaggggca cgtcggcgcc      3480

gcgcgcgggc aggagctggt gctgcgcgcg taggttgctg gcgaacgcga cgacgcggcg      3540

gttgatctcc tgaatctggc gcctctgcgt gaagacgacg ggcccggtga gcttgagcct      3600

gaaagagagt tcgacagaat caatttcggt gtcgttgacg gcggcctggc gcaaaatctc      3660

ctgcacgtct cctgagttgt cttgataggc gatctcggcc atgaactgct cgatctcttc      3720

ctcctggaga tctccgcgtc cggctcgctc cacggtggcg gcgaggtcgt tggaaatgcg      3780

ggccatgagc tgcgagaagg cgttgaggcc tccctcgttc cagacgcggc tgtagaccac      3840

gcccccttcg gcatcgcggg cgcgcatgac cacctgcgcg agattgagct ccacgtgccg      3900

ggcgaagacg gcgtagtttc gcaggcgctg aaagaggtag ttgagggtgg tggcggtgtg      3960

ttctgccacg aagaagtaca taacccagcg tcgcaacgtg gattcgttga tatcccccaa      4020

ggcctcaagg cgctccatgg cctcgtagaa gtccacggcg aagttgaaaa actgggagtt      4080

gcgcgccgac acggttaact cctcctccag aagacggatg agctcggcga cagtgtcgcg      4140

cacctcgcgc tcaaaggcta caggggcctc ttcttcttct tcaatctcct cttccataag      4200

ggcctcccct tcttcttctt ctggcggcgg tgggggaggg gggacacggc ggcgacgacg      4260

gcgcaccggg aggcggtcga caaagcgctc gatcatctcc ccgcggcgac ggcgcatggt      4320

ctcggtgacg gcgcggccgt tctcgcgggg gcgcagttgg aagacgccgc ccgtcatgtc      4380

ccggttatgg gttggcgggg ggctgccatg cggcagggat acggcgctaa cgatgcatct      4440

caacaattgt tgtgtaggta ctccgccgcc gagggacctg agcgagtccg catcgaccgg      4500

atcggaaaac ctctcgagaa aggcgtctaa ccagtcacag tcgcaaggta ggctgagcac      4560

cgtggcgggc ggcagcgggc ggcggtcggg gttgtttctg gcggaggtgc tgctgatgat      4620

gtaattaaag taggcggtct tgagacggcg gatggtcgac agaagcacca tgtccttggg      4680

tccggcctgc tgaatgcgca ggcggtcggc catgccccag gcttcgtttt gacatcggcg      4740

caggtctttg tagtagtctt gcatgagcct ttctaccggc acttcttctt ctccttcctc      4800

ttgtcctgca tctcttgcat ctatcgctgc ggcggcggcg gagtttggcc gtaggtggcg      4860

ccctcttcct cccatgcgtg tgaccccgaa gcccctcatc ggctgaagca gggctaggtc      4920

ggcgacaacg cgctcggcta atatggcctg ctgcacctgc gtgagggtag actggaagtc      4980

atccatgtcc acaaagcggt ggtatgcgcc cgtgttgatg gtgtaagtgc agttggccat      5040

aacggaccag ttaacggtct ggtgacccgg ctgcgagagc tcggtgtacc tgagacgcga      5100

gtaagccctc gagtcaaata cgtagtcgtt gcaagtccgc accaggtact ggtatcccac      5160

caaaaagtgc ggcggcggct ggcggtagag gggccagcgt agggtggccg gggctccggg      5220

ggcgagatct tccaacataa ggcgatgata tccgtagatg tacctggaca tccaggtgat      5280

gccggcggcg gtggtggagg cgcgcggaaa gtcgcggacg cggttccaga tgttgcgcag      5340

cggcaaaaag tgctccatgg tcgggacgct ctggccggtc aggcgcgcgc aatcgttgac      5400

gctctaccgt gcaaaaggag agcctgtaag cgggcactct tccgtggtct ggtggataaa      5460

ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc cgtatccggc cgtccgccgt      5520

gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg cgacgtcaga caacggggga      5580

gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc gctagctttt ttggccactg      5640

gccgcgcgca gcgtaagcgg ttaggctgga aagcgaaagc attaagtggc tcgctccctg      5700

tagccggagg gttattttcc aagggttgag tcgcgggacc cccggttcga gtctcggacc      5760

ggccggactg cggcgaacgg gggtttgcct ccccgtcatg caagaccccg cttgcaaatt      5820

cctccggaaa cagggacgag cccctttttt gcttttccca gatgcatccg gtgctgcggc      5880

agatgcgccc ccctcctcag cagcggcaag agcaagagca gcggcagaca tgcagggcac      5940

cctcccctcc tcctaccgcg tcaggagggg cgacatccgc ggttgacgcg gcagcagatg      6000

gtgattacga acccccgcgg cgccgggccc ggcactacct ggacttggag gagggcgagg      6060

gcctggcgcg gctaggagcg ccctctcctg agcggtaccc aagggtgcag ctgaagcgtg      6120

atacgcgtga ggcgtacgtg ccgcggcaga acctgtttcg cgaccgcgag ggagaggagc      6180

ccgaggagat gcgggatcga aagttccacg cagggcgcga gctgcggcat ggcctgaatc      6240

gcgagcggtt gctgcgcgag gaggactttg agcccgacgc gcgaaccggg attagtcccg      6300

cgcgcgcaca cgtggcggcc gccgacctgg taaccgcata cgagcagacg gtgaaccagg      6360

agattaactt tcaaaaaagc tttaacaacc acgtgcgtac gcttgtggcg cgcgaggagg      6420

tggctatagg actgatgcat ctgtgggact ttgtaagcgc gctggagcaa aacccaaata      6480

gcaagccgct catggcgcag ctgttcctta tagtgcagca cagcagggac aacgaggcat      6540

tcagggatgc gctgctaaac atagtagagc ccgagggccg ctggctgctc gatttgataa      6600

acatcctgca gagcatagtg gtgcaggagc gcagcttgag cctggctgac aaggtggccg      6660

ccatcaacta ttccatgctt agcctgggca agttttacgc ccgcaagata taccataccc      6720

cttacgttcc catagacaag gaggtaaaga tcgaggggtt ctacatgcgc atggcgctga      6780

aggtgcttac cttgagcgac gacctgggcg tttatcgcaa cgagcgcatc cacaaggccg      6840

tgagcgtgag ccggcggcgc gagctcagcg accgcgagct gatgcacagc ctgcaaaggg      6900

ccctggctgg cacgggcagc ggcgatagag aggccgagtc ctactttgac gcgggcgctg      6960

acctgcgctg ggccccaagc cgacgcgccc tggaggcagc tggggccgga cctgggctgg      7020

cggtggcacc cgcgcgcgct ggcaacgtcg gcggcgtgga ggaatatgac gaggacgatg      7080

agtacgagcc agaggacggc gagtactaag cggtgatgtt tctgatcaga tgatgcaaga      7140

cgcaacggac ccggcggtgc gggcggcgct gcagagccag ccgtccggcc ttaactccac      7200

ggacgactgg cgccaggtca tggaccgcat catgtcgctg actgcgcgca atcctgacgc      7260

gttccggcag cagccgcagg ccaaccggct ctccgcaatt ctggaagcgg tggtcccggc      7320

gcgcgcaaac cccacgcacg agaaggtgct ggcgatcgta aacgcgctgg ccgaaaacag      7380

ggccatccgg cccgacgagg ccggcctggt ctacgacgcg ctgcttcagc gcgtggctcg      7440

ttacaacagc ggcaacgtgc agaccaacct ggaccggctg gtgggggatg tgcgcgaggc      7500

cgtggcgcag cgtgagcgcg cgcagcagca gggcaacctg ggctccatgg ttgcactaaa      7560

cgccttcctg agtacacagc ccgccaacgt gccgcgggga caggaggact acaccaactt      7620

tgtgagcgca ctgcggctaa tggtgactga gacaccgcaa agtgaggtgt accagtctgg      7680

gccagactat tttttccaga ccagtagaca aggcctgcag accgtaaacc tgagccaggc      7740

tttcaaaaac ttgcaggggc tgtggggggt gcgggctccc acaggcgacc gcgcgaccgt      7800

gtctagcttg ctgacgccca actcgcgcct gttgctgctg ctaatagcgc ccttcacgga      7860

cagtggcagc gtgtcccggg acacatacct aggtcacttg ctgacactgt accgcgaggc      7920

cataggtcag gcgcatgtgg acgagcatac tttccaggag attacaagtg tcagccgcgc      7980

gctggggcag gaggacacgg gcagcctgga ggcaacccta aactacctgc tgaccaaccg      8040

gcggcagaag atcccctcgt tgcacagttt aaacagcgag gaggagcgca ttttgcgcta      8100

cgtgcagcag agcgtgagcc ttaacctgat gcgcgacggg gtaacgccca gcgtggcgct      8160

ggacatgacc gcgcgcaaca tggaaccggg catgtatgcc tcaaaccggc cgtttatcaa      8220

ccgcctaatg gactacttgc atcgcgcggc cgccgtgaac cccgagtatt tcaccaatgc      8280

catcttgaac ccgcactggc taccgccccc tggtttctac accgggggat tcgaggtgcc      8340

cgagggtaac gatggattcc tctgggacga catagacgac agcgtgtttt ccccgcaacc      8400

gcagaccctg ctagagttgc aacagcgcga gcaggcagag gcggcgctgc gaaaggaaag      8460

cttccgcagg ccaagcagct tgtccgatct aggcgctgcg gccccgcggt cagatgctag      8520

tagcccattt ccaagcttga tagggtctct taccagcact cgcaccaccc gcccgcgcct      8580

gctgggcgag gaggagtacc taaacaactc gctgctgcag ccgcagcgcg aaaaaaacct      8640

gcctccggca tttcccaaca acgggataga gagcctagtg gacaagatga gtagatggaa      8700

gacgtacgcg caggagcaca gggacgtgcc aggcccgcgc ccgcccaccc gtcgtcaaag      8760

gcacgaccgt cagcggggtc tggtgtggga ggacgatgac tcggcagacg acagcagcgt      8820

cctggatttg ggagggagtg gcaacccgtt tgcgcacctt cgccccaggc tggggagaat      8880

gttttaaaaa aaaaaaagca tgatgcaaaa taaaaaactc accaaggcca tggcaccgag      8940

cgttggtttt cttgtattcc ccttagtatg cggcgcgcgg cgatgtatga ggaaggtcct      9000

cctccctcct acgagagtgt ggtgagcgcg gcgccagtgg cggcggcgct gggttctccc      9060

ttcgatgctc ccctggaccc gccgtttgtg cctccgcggt acctgcggcc taccgggggg      9120

agaaacagca tccgttactc tgagttggca cccctattcg acaccacccg tgtgtacctg      9180

gtggacaaca agtcaacgga tgtggcatcc ctgaactacc agaacgacca cagcaacttt      9240

ctgaccacgg tcattcaaaa caatgactac agcccggggg aggcaagcac acagaccatc      9300

aatcttgacg accggtcgca ctggggcggc gacctgaaaa ccatcctgca taccaacatg      9360

ccaaatgtga acgagttcat gtttaccaat aagtttaagg cgcgggtgat ggtgtcgcgc      9420

ttgcctacta aggacaatca ggtggagctg aaatacgagt gggtggagtt cacgctgccc      9480

gagggcaact actccgagac catgaccata gaccttatga acaacgcgat cgtggagcac      9540

tacttgaaag tgggcagaca gaacggggtt ctggaaagcg acatcggggt aaagtttgac      9600

acccgcaact tcagactggg gtttgacccc gtcactggtc ttgtcatgcc tggggtatat      9660

acaaacgaag ccttccatcc agacatcatt ttgctgccag gatgcggggt ggacttcacc      9720

cacagccgcc tgagcaactt gttgggcatc cgcaagcggc aacccttcca ggagggcttt      9780

aggatcacct acgatgatct ggagggtggt aacattcccg cactgttgga tgtggacgcc      9840

taccaggcga gcttgaaaga tgacaccgaa cagggcgggg gtggcgcagg cggcagcaac      9900

agcagtggca gcggcgcgga agagaactcc aacgcggcag ccgcggcaat gcagccggtg      9960

gaggacatga acgatcatgc cattcgcggc gacacctttg ccacacgggc tgaggagaag     10020

cgcgctgagg ccgaagcagc ggccgaagct gccgcccccg ctgcgcaacc cgaggtcgag     10080

aagcctcaga agaaaccggt gatcaaaccc ctgacagagg acagcaagaa acgcagttac     10140

aacctaataa gcaatgacag caccttcacc cagtaccgca gctggtacct tgcatacaac     10200

tacggcgacc ctcagaccgg aatccgctca tggaccctgc tttgcactcc tgacgtaacc     10260

tgcggctcgg agcaggtcta ctggtcgttg ccagacatga tgcaagaccc cgtgaccttc     10320

cgctccacgc gccagatcag caactttccg gtggtgggcg ccgagctgtt gcccgtgcac     10380

tccaagagct tctacaacga ccaggccgtc tactcccaac tcatccgcca gtttacctct     10440

ctgacccacg tgttcaatcg ctttcccgag aaccagattt tggcgcgccc gccagccccc     10500

accatcacca ccgtcagtga aaacgttcct gctctcacag atcacgggac gctaccgctg     10560

cgcaacagca tcggaggagt ccagcgagtg accattactg acgccagacg ccgcacctgc     10620

ccctacgttt acaaggccct gggcatagtc tcgccgcgcg tcctatcgag ccgcactttt     10680

tgagcaagca tgtccatcct tatatcgccc agcaataaca caggctgggg cctgcgcttc     10740

ccaagcaaga tgtttggcgg ggccaagaag cgctccgacc aacacccagt gcgcgtgcgc     10800

gggcactacc gcgcgccctg gggcgcgcac aaacgcggcc gcactgggcg caccaccgtc     10860

gatgacgcca tcgacgcggt ggtggaggag gcgcgcaact acacgcccac gccgccacca     10920

gtgtccacag tggacgcggc cattcagacc gtggtgcgcg gagcccggcg ctatgctaaa     10980

atgaagagac ggcggaggcg cgtagcacgt cgccaccgcc gccgacccgg cactgccgcc     11040

caacgcgcgg cggcggccct gcttaaccgc gcacgtcgca ccggccgacg ggcggccatg     11100

cgggccgctc gaaggctggc cgcgggtatt gtcactgtgc cccccaggtc caggcgacga     11160

gcggccgccg cagcagccgc ggccattagt gctatgactc agggtcgcag gggcaacgtg     11220

tattgggtgc gcgactcggt tagcggcctg cgcgtgcccg tgcgcacccg ccccccgcgc     11280

aactagattg caagaaaaaa ctacttagac tcgtactgtt gtatgtatcc agcggcggcg     11340

gcgcgcaacg aagctatgtc caagcgcaaa atcaaagaag agatgctcca ggtcatcgcg     11400

ccggagatct atggcccccc gaagaaggaa gagcaggatt acaagccccg aaagctaaag     11460

cgggtcaaaa agaaaaagaa agatgatgat gatgaacttg acgacgaggt ggaactgctg     11520

cacgctaccg cgcccaggcg acgggtacag tggaaaggtc gacgcgtaaa acgtgttttg     11580

cgacccggca ccaccgtagt ctttacgccc ggtgagcgct ccacccgcac ctacaagcgc     11640

gtgtatgatg aggtgtacgg cgacgaggac ctgcttgagc aggccaacga gcgcctcggg     11700

gagtttgcct acggaaagcg gcataaggac atgctggcgt tgccgctgga cgagggcaac     11760

ccaacaccta gcctaaagcc cgtaacactg cagcaggtgc tgcccgcgct tgcaccgtcc     11820

gaagaaaagc gcggcctaaa gcgcgagtct ggtgacttgg cacccaccgt gcagctgatg     11880

gtacccaagc gccagcgact ggaagatgtc ttggaaaaaa tgaccgtgga acctgggctg     11940

gagcccgagg tccgcgtgcg gccaatcaag caggtggcgc cgggactggg cgtgcagacc     12000

gtggacgttc agatacccac taccagtagc accagtattg ccaccgccac agagggcatg     12060

gagacacaaa cgtccccggt tgcctcagcg gtggcggatg ccgcggtgca ggcggtcgct     12120

gcggccgcgt ccaagacctc tacggaggtg caaacggacc cgtggatgtt tcgcgtttca     12180

gccccccggc gcccgcgcgg ttcgaggaag tacggcgccg ccagcgcgct actgcccgaa     12240

tatgccctac atccttccat tgcgcctacc cccggctatc gtggctacac ctaccgcccc     12300

agaagacgag caactacccg acgccgaacc accactggaa cccgccgccg ccgtcgccgt     12360

cgccagcccg tgctggcccc gatttccgtg cgcagggtgg ctcgcgaagg aggcaggacc     12420

ctggtgctgc caacagcgcg ctaccacccc agcatcgttt aaaagccggt ctttgtggtt     12480

cttgcagata tggccctcac ctgccgcctc cgtttcccgg tgccgggatt ccgaggaaga     12540

atgcaccgta ggaggggcat ggccggccac ggcctgacgg gcggcatgcg tcgtgcgcac     12600

caccggcggc ggcgcgcgtc gcaccgtcgc atgcgcggcg gtatcctgcc cctccttatt     12660

ccactgatcg ccgcggcgat tggcgccgtg cccggaattg catccgtggc cttgcaggcg     12720

cagagacact gattaaaaac aagttgcatg tggaaaaatc aaaataaaaa gtctggactc     12780

tcacgctcgc ttggtcctgt aactattttg tagaatggaa gacatcaact ttgcgtctct     12840

ggccccgcga cacggctcgc gcccgttcat gggaaactgg caagatatcg gcaccagcaa     12900

tatgagcggt ggcgccttca gctggggctc gctgtggagc ggcattaaaa atttcggttc     12960

caccgttaag aactatggca gcaaggcctg gaacagcagc acaggccaga tgctgaggga     13020

taagttgaaa gagcaaaatt tccaacaaaa ggtggtagat ggcctggcct ctggcattag     13080

cggggtggtg gacctggcca accaggcagt gcaaaataag attaacagta agcttgatcc     13140

ccgccctccc gtagaggagc ctccaccggc cgtggagaca gtgtctccag aggggcgtgg     13200

cgaaaagcgt ccgcgccccg acagggaaga aactctggtg acgcaaatag acgagcctcc     13260

ctcgtacgag gaggcactaa agcaaggcct gcccaccacc cgtcccatcg cgcccatggc     13320

taccggagtg ctgggccagc acacacccgt aacgctggac ctgcctcccc ccgccgacac     13380

ccagcagaaa cctgtgctgc caggcccgac cgccgttgtt gtaacccgtc ctagccgcgc     13440

gtccctgcgc cgcgccgcca gcggtccgcg atcgttgcgg cccgtagcca gtggcaactg     13500

gcaaagcaca ctgaacagca tcgtgggtct gggggtgcaa tccctgaagc gccgacgatg     13560

cttctgaata gctaacgtgt cgtatgtgtg tcatgtatgc gtccatgtcg ccgccagagg     13620

agctgctgag ccgccgcgcg cccgctttcc aagatggcta ccccttcgat gatgccgcag     13680

tggtcttaca tgcacatctc gggccaggac gcctcggagt acctgagccc cgggctggtg     13740

cagtttgccc gcgccaccga gacgtacttc agcctgaata acaagtttag aaaccccacg     13800

gtggcgccta cgcacgacgt gaccacagac cggtcccagc gtttgacgct gcggttcatc     13860

cctgtggacc gtgaggatac tgcgtactcg tacaaggcgc ggttcaccct agctgtgggt     13920

gataaccgtg tgctggacat ggcttccacg tactttgaca tccgcggcgt gctggacagg     13980

ggccctactt ttaagcccta ctctggcact gcctacaacg ccctggctcc caagggtgcc     14040

ccaaatcctt gcgaatggga tgaagctgct actgctcttg aaataaacct agaagaagag     14100

gacgatgaca acgaagacga agtagacgag caagctgagc agcaaaaaac tcacgtattt     14160

gggcaggcgc cttattctgg tataaatatt acaaaggagg gtattcaaat aggtgtcgaa     14220

ggtcaaacac ctaaatatgc cgataaaaca tttcaacctg aacctcaaat aggagaatct     14280

cagtggtacg aaactgaaat taatcatgca gctgggagag tccttaaaaa gactacccca     14340

atgaaaccat gttacggttc atatgcaaaa cccacaaatg aaaatggagg gcaaggcatt     14400

cttgtaaagc aacaaaatgg aaagctagaa agtcaagtgg aaatgcaatt tttctcaact     14460

actgaggcga ccgcaggcaa tggtgataac ttgactccta aagtggtatt gtacagtgaa     14520

gatgtagata tagaaacccc agacactcat atttcttaca tgcccactat taaggaaggt     14580

aactcacgag aactaatggg ccaacaatct atgcccaaca ggcctaatta cattgctttt     14640

agggacaatt ttattggtct aatgtattac aacagcacgg gtaatatggg tgttctggcg     14700

ggccaagcat cgcagttgaa tgctgttgta gatttgcaag acagaaacac agagctttca     14760

taccagcttt tgcttgattc cattggtgat agaaccaggt acttttctat gtggaatcag     14820

gctgttgaca gctatgatcc agatgttaga attattgaaa atcatggaac tgaagatgaa     14880

cttccaaatt actgctttcc actgggaggt gtgattaata cagagactct taccaaggta     14940

aaacctaaaa caggtcagga aaatggatgg gaaaaagatg ctacagaatt ttcagataaa     15000

aatgaaataa gagttggaaa taattttgcc atggaaatca atctaaatgc caacctgtgg     15060

agaaatttcc tgtactccaa catagcgctg tatttgcccg acaagctaaa gtacagtcct     15120

tccaacgtaa aaatttctga taacccaaac acctacgact acatgaacaa gcgagtggtg     15180

gctcccgggt tagtggactg ctacattaac cttggagcac gctggtccct tgactatatg     15240

gacaacgtca acccatttaa ccaccaccgc aatgctggcc tgcgctaccg ctcaatgttg     15300

ctgggcaatg gtcgctatgt gcccttccac atccaggtgc ctcagaagtt ctttgccatt     15360

aaaaacctcc ttctcctgcc gggctcatac acctacgagt ggaacttcag gaaggatgtt     15420

aacatggttc tgcagagctc cctaggaaat gacctaaggg ttgacggagc cagcattaag     15480

tttgatagca tttgccttta cgccaccttc ttccccatgg cccacaacac cgcctccacg     15540

cttgaggcca tgcttagaaa cgacaccaac gaccagtcct ttaacgacta tctctccgcc     15600

gccaacatgc tctaccctat acccgccaac gctaccaacg tgcccatatc catcccctcc     15660

cgcaactggg cggctttccg cggctgggcc ttcacgcgcc ttaagactaa ggaaacccca     15720

tcactgggct cgggctacga cccttattac acctactctg gctctatacc ctacctagat     15780

ggaacctttt acctcaacca cacctttaag aaggtggcca ttacctttga ctcttctgtc     15840

agctggcctg gcaatgaccg cctgcttacc cccaacgagt ttgaaattaa gcgctcagtt     15900

gacggggagg gttacaacgt tgcccagtgt aacatgacca aagactggtt cctggtacaa     15960

atgctagcta actacaacat tggctaccag ggcttctata tcccagagag ctacaaggac     16020

cgcatgtact ccttctttag aaacttccag cccatgagcc gtcaggtggt ggatgatact     16080

aaatacaagg actaccaaca ggtgggcatc ctacaccaac acaacaactc tggatttgtt     16140

ggctaccttg cccccaccat gcgcgaagga caggcctacc ctgctaactt cccctatccg     16200

cttataggca agaccgcagt tgacagcatt acccagaaaa agtttctttg cgatcgcacc     16260

ctttggcgca tcccattctc cagtaacttt atgtccatgg gcgcactcac agacctgggc     16320

caaaaccttc tctacgccaa ctccgcccac gcgctagaca tgacttttga ggtggatccc     16380

atggacgagc ccacccttct ttatgttttg tttgaagtct ttgacgtggt ccgtgtgcac     16440

cggccgcacc gcggcgtcat cgaaaccgtg tacctgcgca cgcccttctc ggccggcaac     16500

gccacaacat aaagaagcaa gcaacatcaa caacagctgc cgccatgggc tccagtgagc     16560

aggaactgaa agccattgtc aaagatcttg gttgtgggcc atattttttg ggcacctatg     16620

acaagcgctt tccaggcttt gtttctccac acaagctcgc ctgcgccata gtcaatacgg     16680

ccggtcgcga gactgggggc gtacactgga tggcctttgc ctggaacccg cactcaaaaa     16740

catgctacct ctttgagccc tttggctttt ctgaccagcg actcaagcag gtttaccagt     16800

ttgagtacga gtcactcctg cgccgtagcg ccattgcttc ttcccccgac cgctgtataa     16860

cgctggaaaa gtccacccaa agcgtacagg ggcccaactc ggccgcctgt ggactattct     16920

gctgcatgtt tctccacgcc tttgccaact ggccccaaac tcccatggat cacaacccca     16980

ccatgaacct tattaccggg gtacccaact ccatgctcaa cagtccccag gtacagccca     17040

ccctgcgtcg caaccaggaa cagctctaca gcttcctgga gcgccactcg ccctacttcc     17100

gcagccacag tgcgcagatt aggagcgcca cttctttttg tcacttgaaa aacatgtaaa     17160

aataatgtac tagagacact ttcaataaag gcaaatgctt ttatttgtac actctcgggt     17220

gattatttac ccccaccctt gccgtctgcg ccgtttaaaa atcaaagggg ttctgccgcg     17280

catcgctatg cgccactggc agggacacgt tgcgatactg gtgtttagtg ctccacttaa     17340

actcaggcac aaccatccgc ggcagctcgg tgaagttttc actccacagg ctgcgcacca     17400

tcaccaacgc gtttagcagg tcgggcgccg atatcttgaa gtcgcagttg gggcctccgc     17460

cctgcgcgcg cgagttgcga tacacagggt tgcagcactg gaacactatc agcgccgggt     17520

ggtgcacgct ggccagcacg ctcttgtcgg agatcagatc cgcgtccagg tcctccgcgt     17580

tgctcagggc gaacggagtc aactttggta gctgccttcc caaaaagggc gcgtgcccag     17640

gctttgagtt gcactcgcac cgtagtggca tcaaaaggtg accgtgcccg gtctgggcgt     17700

taggatacag cgcctgcata aaagccttga tctgcttaaa agccacctga gcctttgcgc     17760

cttcagagaa gaacatgccg caagacttgc cggaaaactg attggccgga caggccgcgt     17820

cgtgcacgca gcaccttgcg tcggtgttgg agatctgcac cacatttcgg ccccaccggt     17880

tcttcacgat cttggccttg ctagactgct ccttcagcgc gcgctgcccg ttttcgctcg     17940

tcacatccat ttcaatcacg tgctccttat ttatcataat gcttccgtgt agacacttaa     18000

gctcgccttc gatctcagcg cagcggtgca gccacaacgc gcagcccgtg ggctcgtgat     18060

gcttgtaggt cacctctgca aacgactgca ggtacgcctg caggaatcgc cccatcatcg     18120

tcacaaaggt cttgttgctg gtgaaggtca gctgcaaccc gcggtgctcc tcgttcagcc     18180

aggtcttgca tacggccgcc agagcttcca cttggtcagg cagtagtttg aagttcgcct     18240

ttagatcgtt atccacgtgg tacttgtcca tcagcgcgcg cgcagcctcc atgcccttct     18300

cccacgcaga cacgatcggc acactcagcg ggttcatcac cgtaatttca ctttccgctt     18360

cgctgggctc ttcctcttcc tcttgcgtcc gcataccacg cgccactggg tcgtcttcat     18420

tcagccgccg cactgtgcgc ttacctcctt tgccatgctt gattagcacc ggtgggttgc     18480

tgaaacccac catttgtagc gccacatctt ctctttcttc ctcgctgtcc acgattacct     18540

ctggtgatgg cgggcgctcg ggcttgggag aagggcgctt ctttttcttc ttgggcgcaa     18600

tggccaaatc cgccgccgag gtcgatggcc gcgggctggg tgtgcgcggc accagcgcgt     18660

cttgtgatga gtcttcctcg tcctcggact cgatacgccg cctcatccgc ttttttgggg     18720

gcgcccgggg aggcggcggc gacggggacg gggacgacac gtcctccatg gttgggggac     18780

gtcgcgccgc accgcgtccg cgctcggggg tggtttcgcg ctgctcctct tcccgactgg     18840

ccatttcctt ctcctatagg cagaaaaaga tcatggagtc agtcgagaag aaggacagcc     18900

taaccgcccc ctctgagttc gccaccaccg cctccaccga tgccgccaac gcgcctacca     18960

ccttccccgt cgaggcaccc ccgcttgagg aggaggaagt gattatcgag caggacccag     19020

gttttgtaag cgaagacgac gaggaccgct cagtaccaac agaggataaa aagcaagacc     19080

aggacaacgc agaggcaaac gaggaacaag tcgggcgggg ggacgaaagg catggcgact     19140

acctagatgt gggagacgac gtgctgttga agcatctgca gcgccagtgc gccattatct     19200

gcgacgcgtt gcaagagcgc agcgatgtgc ccctcgccat agcggatgtc agccttgcct     19260

acgaacgcca cctattctca ccgcgcgtac cccccaaacg ccaagaaaac ggcacatgcg     19320

agcccaaccc gcgcctcaac ttctaccccg tatttgccgt gccagaggtg cttgccacct     19380

atcacatctt tttccaaaac tgcaagatac ccctatcctg ccgtgccaac cgcagccgag     19440

cggacaagca gctggccttg cggcagggcg ctgtcatacc tgatatcgcc tcgctcaacg     19500

aagtgccaaa aatctttgag ggtcttggac gcgacgagaa gcgcgcggca aacgctctgc     19560

aacaggaaaa cagcgaaaat gaaagtcact ctggagtgtt ggtggaactc gagggtgaca     19620

acgcgcgcct agccgtacta aaacgcagca tcgaggtcac ccactttgcc tacccggcac     19680

ttaacctacc ccccaaggtc atgagcacag tcatgagtga gctgatcgtg cgccgtgcgc     19740

agcccctgga gagggatgca aatttgcaag aacaaacaga ggagggccta cccgcagttg     19800

gcgacgagca gctagcgcgc tggcttcaaa cgcgcgagcc tgccgacttg gaggagcgac     19860

gcaaactaat gatggccgca gtgctcgtta ccgtggagct tgagtgcatg cagcggttct     19920

ttgctgaccc ggagatgcag cgcaagctag aggaaacatt gcactacacc tttcgacagg     19980

gctacgtacg ccaggcctgc aagatctcca acgtggagct ctgcaacctg gtctcctacc     20040

ttggaatttt gcacgaaaac cgccttgggc aaaacgtgct tcattccacg ctcaagggcg     20100

aggcgcgccg cgactacgtc cgcgactgcg tttacttatt tctatgctac acctggcaga     20160

cggccatggg cgtttggcag cagtgcttgg aggagtgcaa cctcaaggag ctgcagaaac     20220

tgctaaagca aaacttgaag gacctatgga cggccttcaa cgagcgctcc gtggccgcgc     20280

acctggcgga catcattttc cccgaacgcc tgcttaaaac cctgcaacag ggtctgccag     20340

acttcaccag tcaaagcatg ttgcagaact ttaggaactt tatcctagag cgctcaggaa     20400

tcttgcccgc cacctgctgt gcacttccta gcgactttgt gcccattaag taccgcgaat     20460

gccctccgcc gctttggggc cactgctacc ttctgcagct agccaactac cttgcctacc     20520

actctgacat aatggaagac gtgagcggtg acggtctact ggagtgtcac tgtcgctgca     20580

acctatgcac cccgcaccgc tccctggttt gcaattcgca gctgcttaac gaaagtcaaa     20640

ttatcggtac ctttgagctg cagggtccct cgcctgacga aaagtccgcg gctccggggt     20700

tgaaactcac tccggggctg tggacgtcgg cttaccttcg caaatttgta cctgaggact     20760

accacgccca cgagattagg ttctacgaag accaatcccg cccgccaaat gcggagctta     20820

ccgcctgcgt cattacccag ggccacattc ttggccaatt gcaagccatc aacaaagccc     20880

gccaagagtt tctgctacga aagggacggg gggtttactt ggacccccag tccggcgagg     20940

agctcaaccc aatccccccg ccgccgcagc cctatcagca gcagccgcgg gcccttgctt     21000

cccaggatgg cacccaaaaa gaagctgcag ctgccgccgc cacccacgga cgaggaggaa     21060

tactgggaca gtcaggcaga ggaggttttg gacgaggagg aggaggacat gatggaagac     21120

tgggagagcc tagacgagga agcttccgag gtcgaagagg tgtcagacga aacaccgtca     21180

ccctcggtcg cattcccctc gccggcgccc cagaaatcgg caaccggttc cagcatggct     21240

acaacctccg ctcctcaggc gccgccggca ctgcccgttc gccgacccaa ccgtagatgg     21300

gacaccactg gaaccagggc cggtaagtcc aagcagccgc cgccgttagc ccaagagcaa     21360

caacagcgcc aaggctaccg ctcatggcgc gggcacaaga acgccatagt tgcttgcttg     21420

caagactgtg ggggcaacat ctccttcgcc cgccgctttc ttctctacca tcacggcgtg     21480

gccttccccc gtaacatcct gcattactac cgtcatctct acagcccata ctgcaccggc     21540

ggcagcggca gcggcagcaa cagcagcggc cacacagaag caaaggcgac cggatagcaa     21600

gactctgaca aagcccaaga aatccacagc ggcggcagca gcaggaggag gagcgctgcg     21660

tctggcgccc aacgaacccg tatcgacccg cgagcttaga aacaggattt ttcccactct     21720

gtatgctata tttcaacaga gcaggggcca agaacaagag ctgaaaataa aaaacaggtc     21780

tctgcgatcc ctcacccgca gctgcctgta tcacaaaagc gaagatcagc ttcggcgcac     21840

gctggaagac gcggaggctc tcttcagtaa atactgcgcg ctgactctta aggactagtt     21900

tcgcgccctt tctcaaattt aagcgcgaaa actacgtcat ctccagcggc cacacccggc     21960

gccagcacct gtcgtcagcg ccattatgag caaggaaatt cccacgccct acatgtggag     22020

ttaccagcca caaatgggac ttgcggctgg agctgcccaa gactactcaa cccgaataaa     22080

ctacatgagc gcgggacccc acatgatatc ccgggtcaac ggaatccgcg cccaccgaaa     22140

ccgaattctc ttggaacagg cggctattac caccacacct cgtaataacc ttaatccccg     22200

tagttggccc gctgccctgg tgtaccagga aagtcccgct cccaccactg tggtacttcc     22260

cagagacgcc caggccgaag ttcagatgac taactcaggg gcgcagcttg cgggcggctt     22320

tcgtcacagg gtgcggtcgc ccgggcaggg tataactcac ctgacaatca gagggcgagg     22380

tattcagctc aacgacgagt cggtgagctc ctcgcttggt ctccgtccgg acgggacatt     22440

tcagatcggc ggcgccggcc gtccttcatt cacgcctcgt caggcaatcc taactctgca     22500

gacctcgtcc tctgagccgc gctctggagg cattggaact ctgcaattta ttgaggagtt     22560

tgtgccatcg gtctacttta accccttctc gggacctccc ggccactatc cggatcaatt     22620

tattcctaac tttgacgcgg taaaggactc ggcggacggc tacgactgaa tgttaagtgg     22680

agaggcagag caactgcgcc tgaaacacct ggtccactgt cgccgccaca agtgctttgc     22740

ccgcgactcc ggtgagtttt gctactttga attgcccgag gatcatatcg agggcccggc     22800

gcacggcgtc cggcttaccg cccagggaga gcttgcccgt agcctgattc gggagtttac     22860

ccagcgcccc ctgctagttg agcgggacag gggaccctgt gttctcactg tgatttgcaa     22920

ctgtcctaac cttggattac atcaagatcc tctagttata actagagtac ccggggatct     22980

tattcccttt aactaataaa aaaaaataat aaagcatcac ttacttaaaa tcagttagca     23040

aatttctgtc cagtttattc agcagcacct ccttgccctc ctcccagctc tggtattgca     23100

gcttcctcct ggctgcaaac tttctccaca atctaaatgg aatgtcagtt tcctcctgtt     23160

cctgtccatc cgcacccact atcttcatgt tgttgcagat gaagcgcgca agaccgtctg     23220

aagatacctt caaccccgtg tatccatatg acacggaaac cggtcctcca actgtgcctt     23280

ttcttactcc tccctttgta tcccccaatg ggtttcaaga gagtccccct ggggtactct     23340

ctttgcgcct atccgaacct ctagttacct ccaatggcat gcttgcgctc aaaatgggca     23400

acggcctctc tctggacgag gccggcaacc ttacctccca aaatgtaacc actgtgagcc     23460

cacctctcaa aaaaaccaag tcaaacataa acctggaaat atctgcaccc ctcacagtta     23520

cctcagaagc cctaactgtg gctgccgccg cacctctaat ggtcgcgggc aacacactca     23580

ccatgcaatc acaggccccg ctaaccgtgc acgactccaa acttagcatt gccacccaag     23640

gacccctcac agtgtcagaa ggaaagctag ccctgcaaac atcaggcccc ctcaccacca     23700

ccgatagcag tacccttact atcactgcct caccccctct aactactgcc actggtagct     23760

tgggcattga cttgaaagag cccatttata cacaaaatgg aaaactagga ctaaagtacg     23820

gggctccttt gcatgtaaca gacgacctaa acactttgac cgtagcaact ggtccaggtg     23880

tgactattaa taatacttcc ttgcaaacta aagttactgg agccttgggt tttgattcac     23940

aaggcaatat gcaacttaat gtagcaggag gactaaggat tgattctcaa aacagacgcc     24000

ttatacttga tgttagttat ccgtttgatg ctcaaaacca actaaatcta agactaggac     24060

agggccctct ttttataaac tcagcccaca acttggatat taactacaac aaaggccttt     24120

acttgtttac agcttcaaac aattccaaaa agcttgaggt taacctaagc actgccaagg     24180

ggttgatgtt tgacgctaca gccatagcca ttaatgcagg agatgggctt gaatttggtt     24240

cacctaatgc accaaacaca aatcccctca aaacaaaaat tggccatggc ctagaatttg     24300

attcaaacaa ggctatggtt cctaaactag gaactggcct tagttttgac agcacaggtg     24360

ccattacagt aggaaacaaa aataatgata agctaacttt gtggaccaca ccagctccat     24420

ctcctaactg tagactaaat gcagagaaag atgctaaact cactttggtc ttaacaaaat     24480

gtggcagtca aatacttgct acagtttcag ttttggctgt taaaggcagt ttggctccaa     24540

tatctggaac agttcaaagt gctcatctta ttataagatt tgacgaaaat ggagtgctac     24600

taaacaattc cttcctggac ccagaatatt ggaactttag aaatggagat cttactgaag     24660

gcacagccta tacaaacgct gttggattta tgcctaacct atcagcttat ccaaaatctc     24720

acggtaaaac tgccaaaagt aacattgtca gtcaagttta cttaaacgga gacaaaacta     24780

aacctgtaac actaaccatt acactaaacg gtacacagga aacaggagac acaactccaa     24840

gtgcatactc tatgtcattt tcatgggact ggtctggcca caactacatt aatgaaatat     24900

ttgccacatc ctcttacact ttttcataca ttgcccaaga ataaagaatc gtttgtgtta     24960

tgtttcaacg tgtttatttt tcaattgcag aaaatttcaa gtcatttttc attcagtagt     25020

atagccccac caccacatag cttatacaga tcaccgtacc ttaatcaaac tcacagaacc     25080

ctagtattca acctgccacc tccctcccaa cacacagagt acacagtcct ttctccccgg     25140

ctggccttaa aaagcatcat atcatgggta acagacatat tcttaggtgt tatattccac     25200

acggtttcct gtcgagccaa acgctcatca agtgatatta ataaactccc cgggcagctc     25260

acttaagttc atgtcgctgt ccagctgctg agccacaggc tgctgtccaa cttgcggttg     25320

cttaacgggc ggcgaaggag aagtccacgc ctacatgggg ggagagtcat aatcgtgcat     25380

caggataggg cggtggtgct gcagcagcgc gcgaataaac tgctgccgcc gccgctccgt     25440

cctgcaggaa tacaacatgg cagtggtctc ctcagcgatg attcgcaccg cccgcagcat     25500

aaggcgcttg tcctccgggc acagcagcgc accctgatct cacttaaatc agcacagtaa     25560

ctgcagcaca gcaccacaat attgttcaaa atcccacagt gcaaggcgct gtatccaaag     25620

ctcatggcgg ggaccacaga acccacgtgg ccatcatacc acaagcgcag gtagattaag     25680

tggcgacccc tcataaacac gctggacata aacattacct cttttggcat gttgtaattc     25740

accacctccc ggtaccatat aaacctctga ttaaacatgg cgccatccac caccatccta     25800

aaccagctgg ccaaaacctg ccccgccggg ntatacactg cagggaaccg ggacttggac     25860

aatgacaagt gggagagccc aggactcgta accatggatc atcatgctcg tcatgatatc     25920

aatgttggca caacacaggc acacgtgcat acacttcctc aggattacaa gctcctcccg     25980

cgttagaacc atatcccagg gaacaaccca ttcctgaatc agcgtaaatc ccacactgca     26040

gggaagacct cgcacgtaac tcacgttgtg cattgtcaaa gtgttacatt cgggcagcag     26100

cggatgatcc tccagtatgg tagcgcgggt ttctgtctca aaaggaggta gacgatccct     26160

actgtacgga gtgcgccgag acaaccgaga tcgtgttggt cgtagtgtca tgccaaatgg     26220

aacgccggac gtagtcatat ttcctgaagc aaaaccaggt gcgggcgtga caaacagatc     26280

tgcgtctccg gtctcgccgc ttagatcgct ctgtgtagta gttgtagtat atccactctc     26340

tcaaagcatc caggcgcccc ctggcttcgg gttctatgta aactccttca tgcgccgctg     26400

ccctgataac atccaccacc gcagaataag ccacacccag ccaacctaca cattcgttct     26460

gcgagtcaca cacgggagga gcgggaagag ctggaagaac catgtttttt tttttattcc     26520

aaaagattat ccaaaacctc aaaatgaaga tctattaagt gaacgcgctc ccctccggtg     26580

gcgtggtcaa actctacagc caaagaacag ataatggcat ttgtaagatg ttgcacaatg     26640

gcttccaaaa ggcaaacggc cctcacgtcc aagtggacgt aaaggctaaa cccttcaggg     26700

tgaatctcct ctataaacat tccagcacct tcaaccatgc ccaaataatt ctcatctcgc     26760

caccttctca atatatctct aagcaaatcc cgaatattta agtccgggcc attgtaaaaa     26820

atttggctcc agagcgccct ccaccttcag cctcaagcag cgaatcatga ttgcaaaaat     26880

tcaggttcct cacagacctg tataagattc aaaagcggaa cattaacaaa aataccgcga     26940

tcccgtaggt cccttcgcag ggccagctga acataatcgt gcaggtctgc acggaccagc     27000

gcggccactt ccccgccagg aaccatgaca aaagaaccca cactgattat gacacgcata     27060

ctcggagcta tgctaaccag cgtagccccg atgtaagctt gttgcatggg cggcgatata     27120

aaatgcaagg tgctgctcaa aaaatcaggc aaagcctcgc gcaaaaaaga aagcacatcg     27180

tagtcatgct catgcagata aaggcaggta agctccggaa ccaccacaga aaaagacacc     27240

atttttctct caaacatgtc tgcgggtttc tgcataaaca caaaataaaa taacaaaaaa     27300

acatttaaac attagaagcc tgtcttacaa caggaaaaac aacccttata agcataagac     27360

ggactacggc catgccggcg tgaccgtaaa aaaactggtc accgtgatta aaaagcacca     27420

ccgacagctc ctcggtcatg tccggagtca taatgtaaga ctcggtaaac acatcaggtt     27480

gattcatcgg tcagtgctaa aaagcgaccg aaatagcccg ggggaataca tacccgcagg     27540

cgtagagaca acattacagc ccccatagga ggtataacaa aattaatagg agagaaaaac     27600

acataaacac ctgaaaaacc ctcctgccta ggcaaaatag caccctcccg ctccagaaca     27660

acatacagcg cttcacagcg gcagcctaac agtcagcctt accagtaaaa aagaaaacct     27720

attaaaaaaa caccactcga cacggcacca gctcaatcag tcacagtgta aaaaagggcc     27780

aagtgcagag cgagtatata taggactaaa aaatgacgta acggttaaag tccacaaaaa     27840

acacccagaa aaccgcacgc gaacctacgc ccagaaacga aagccaaaaa acccacaact     27900

tcctcaaatc gtcacttccg ttttcccacg ttacgtaact tcccatttta agaaaactac     27960

aattcccaac acatacaagt tactccgccc taaaacctac gtcacccgcc ccgttcccac     28020

gccccgcgcc acgtcacaaa ctccaccccc tcattatcat attggcttca atccaaaata     28080

aggtatatta ttgatgatgt taattaacat gcatggatcc atatgcggtg tgaaataccg     28140

cacagatgcg taaggagaaa ataccgcatc aggcgctctt ccgcttcctc gctcactgac     28200

tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata     28260

cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa     28320

aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct     28380

gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa     28440

agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg     28500

cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca     28560

cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa     28620

ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg     28680

gtaagacacg acttatcgcc actggcagca gccactggta acaggattag cagagcgagg     28740

tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta cactagaagg     28800

acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc     28860

tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag     28920

attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac     28980

gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc     29040

ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag     29100

taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt     29160

ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag     29220

ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca     29280

gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact     29340

ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca     29400

gttaatagtt tgcgcaacgt tgttgccatt gctgcagcca tgagattatc aaaaaggatc     29460

ttcacctaga tccttttcac gtagaaagcc agtccgcaga aacggtgctg accccggatg     29520

aatgtcagct actgggctat ctggacaagg gaaaacgcaa gcgcaaagag aaagcaggta     29580

gcttgcagtg ggcttacatg gcgatagcta gactgggcgg ttttatggac agcaagcgaa     29640

ccggaattgc cagctggggc gccctctggt aaggttggga agccctgcaa agtaaactgg     29700

atggctttct tgccgccaag gatctgatgg cgcaggggat caagctctga tcaagagaca     29760

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     29820

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     29880

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     29940

ggtgccctga atgaactgca agacgaggca gcgcggctat cgtggctggc cacgacgggc     30000

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     30060

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     30120

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     30180

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     30240

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     30300

aaggcgagca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     30360

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     30420

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     30480

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     30540

gccttctatc gccttcttga cgagttcttc tgaattttgt taaaattttt gttaaatcag     30600

ctcatttttt aaccaatagg ccgaaatcgg caacatccct tataaatcaa aagaatagac     30660

cgcgataggg ttgagtgttg ttccagtttg gaacaagagt ccactattaa agaacgtgga     30720

ctccaacgtc aaagggcgaa aaaccgtcta tcagggcgat ggcccactac gtgaaccatc     30780

acccaaatca agttttttgc ggtcgaggtg ccgtaaagct ctaaatcgga accctaaagg     30840

gagcccccga tttagagctt gacggggaaa gccggcgaac gtggcgagaa aggaagggaa     30900

gaaagcgaaa ggagcgggcg ctagggcgct ggcaagtgta gcggtcacgc tgcgcgtaac     30960

caccacaccc gcgcgcttaa tgcgccgcta cagggcgcgt ccattcgcca ttcaggatcg     31020

aattaattct taattaacat catcaataat ataccttatt ttggattgaa gccaatatga     31080

taatgagggg gtggagtttg tgacgtggcg cggggcgtgg gaacggggcg ggtgacgtag     31140

tagtgtggcg gaagtgtgat gttgcaagtg tggcggaaca catgtaagcg acggatgtgg     31200

caaaagtgac gtttttggtg tgcgccggtg tacacaggaa gtgacaattt tcgcgcggtt     31260

ttaggcggat gttgtagtaa atttgggcgt aaccgagtaa gatttggcca ttttcgcggg     31320

aaaactgaat aagaggaagt gaaatctgaa taattttgtg ttactcatag cgcgtaatac     31380

tggtaccgcg gccgcctcga gtctagatta atagcggtcg gcataattaa tggaggcctc     31440

ggcatcactg gtggagggtt gggccacact ctcacgcact ctctttggct cggaaatgtc     31500

ggcgtcggaa ggtgcagggc gctttttggc cccccccttt ttgacgtaga attcatgctc     31560

cacctcaacc acgtgatcct ttgcccaccg gaaaaagtct ttgacttcct gcttggtgac     31620

cttcccaaag tcatgatcca gacggcgggt gagttcaaat ttgaacatcc ggtcttgcaa     31680

cggctgctgg tgttcgaagg tcgttgagtt cccgtcaatc acggcgcaca tgttggtgtt     31740

ggaggtgacg atcacgggag tcgggtctat ctgggccgag gacttgcatt tctggtccac     31800

gcgcaccttg cttcctccga gaatggcttt ggccgactcc acgaccttgg cggtcatctt     31860

cccctcctcc caccagatca ccatcttgtc gacacagtcg ttgaagggaa agttctcatt     31920

ggtccagttt acgcacccgt agaagggcac agtgtgggct atggcctccg cgatgttggt     31980

cttcccggta gttgcaggcc caaacagcca gatggtgttc ctcttgccga actttttcgt     32040

ggcccatccc agaaagacgg aagccgcata ttggggatcg tacccgttta gttccaaaat     32100

tttataaatc cgattgctgg aaatgtcctc cacgggctgc tggcccacca ggtagtcggg     32160

ggcggtttta gtcaggctca taatctttcc cgcattgtcc aaggcagcct tgatttggga     32220

ccgcgagttg gaggccgcat tgaaggagat gtatgaggcc tggtcctcct ggatccactg     32280

cttctccgag gtaatcccct tgtccacgag ccacccgacc agctccatgt acctggctga     32340

agtttttgat ctgatcaccg gcgcatcaga attgggattc tgattctctt tgttctgctc     32400

ctgcgtctgc gacacgtgcg tcagatgctg cgccaccaac cgtttacgct ccgtgagatt     32460

caaacaggcg cttaaatact gttccatatt agtccacgcc cactggagct caggctgggt     32520

tttggggagc aagtaattgg ggatgtagca ctcatccacc accttgttcc cgcctccggc     32580

gccatttctg gtctttgtga ccgcgaacca gtttggcaaa gtcggctcga tcccgcggta     32640

aattctctga atcagttttt cgcgaatctg actcaggaaa cgtcccaaaa ccatggattt     32700

caccccggtg gtttccacga gcacgtgcat gtggaagtag ctctctccct tctcaaattg     32760

cacaaagaaa agggcctccg gggccttact cacacggcgc cattccgtca gaaagtcgcg     32820

ctgcagcttc tcggccacgg tcaggggtgc ctgctcaatc agattcagat ccatgtcaga     32880

atctggcggc aactcccatt ccttctcggc cacccagttc acaaagctgt cagaaatgcc     32940

gggcagatgc ccgtcaaggt cgctggggac cttaatcaca atctcgtaaa accccggcat     33000

ggcaccggtg cacgctgttg acgctgttaa gcgggtcgct gcagggtcgc tcggtgttcg     33060

aggccacacg cgtcacctta atatgcgaag tggacctggg accgcgccgc cccgactgca     33120

tctgcgtgtt cgaattcgcc aatgacaaga cgctgggcgg ggtttgtgtc atcatagaac     33180

taaagacatg caaatatatt tcttccgggg acaccgccag caaacgcgag caacgggcca     33240

cggggatgaa gcagactagt cataagcttg tcgactcgaa gatctgggcg tggttaaggg     33300

tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg     33360

ccgccgccat gagcaccaac tcgtttgatg gaagcattgt gagctcatat ttgacaacgc     33420

gcatgccccc atgggccggg gtgcgtcaga atgtgatggg ctccagcatt gatggtcgcc     33480

ccgtcctgcc cgcaaactct actaccttga cctacgagac cgtgtctgga acgccgttgg     33540

agactgcagc ctccgccgcc gcttcagccg ctgcagccac cgcccgcggg attgtgactg     33600

actttgcttt cctgagcccg cttgcaagca gtgcagcttc ccgttcatcc gcccgcgatg     33660

acaagttgac ggctcttttg gcacaattgg attctttgac ccgggaactt aatgtcgttt     33720

ctcagcagct gttggatctg cgccagcagg tttctgccct gaaggcttcc tcccctccca     33780

atgcggttta aaacataaat aaaaaaccag actctgtttg gatttggatc aagcaagtgt     33840

cttgctgtct ttatttaggg gttttgcgcg cgcggtaggc ccgggaccag cggtctcggt     33900

cgttgagggt cctgtgtatt ttttccagga cgtggtaaag gtgactctgg atgttcagat     33960

acatgggcat aagcccgtct ctggggtgga ggtagcacca ctgcagagct tcatgctgcg     34020

gggtggtgtt gtagatgatc cagtcgtagc aggagcgctg ggcgtggtgc ctaaaaatgt     34080

ctttcagtag caagctgatt gccaggggca ggcccttggt gtaagtgttt acaaagcggt     34140

taagctggga tgggtgcata cgtggggata tgagatgcat cttggactgt atttttaggt     34200

tggctatgtt cccagccata tccctccggg gattcatgtt gtgcagaacc accagcacag     34260

tgtatccggt gcacttggga aatttgtcat gtagcttaga aggaaatgcg tggaagaact     34320

tggagacgcc cttgtgacct ccaagatttt ccatgcattc gtccataatg atggcaatgg     34380

gcccacgggc ggcggcctgg gcgaagatat ttctgggatc actaacgtca tagttgtgtt     34440

ccaggatgag atcgtcatag gccattttta caaagcgcgg gcggagggtg ccagactgcg     34500

gtataatggt tccatccggc ccaggggcgt agttaccctc acagatttgc atttcccacg     34560

ctttgagttc agatgggggg atcatgtcta cctgcggggc gatgaagaaa acggtttccg     34620

gggtagggga gatcagctgg gaagaaagca ggttcctgag cagctgcgac ttaccgcagc     34680

cggtgggccc gtaaatcaca cctattaccg ggtgcaactg gtagttaaga gagctgcagc     34740

tgccgtcatc cctgagcagg ggggccactt cgttaagcat gtccctgact cgcatgtttt     34800

ccctgaccaa atccgccaga aggcgctcgc cgcccagcga tagcagttct tgcaaggaag     34860

caaagttttt caacggtttg agaccgtccg ccgtaggcat gcttttgagc gtttgaccaa     34920

gcagttccag gcggtcccac agctcg                                          34946


<210> 8
<211> 156
<212> DNA
<213> Artificial Sequence


<220> 
<223> Recoded p40 promoter 1

<400> 8
gtcaccaagc aggaagtcaa agactttttc cggtgggcaa aggatcacgt ggttgaggtg     60

gagcatgaat tctacgtcaa aaaggggggg gccaaaaagc gccctgcacc ttccgacgcc    120

gacatttccg agccaaagag agtgcgtgag agtgtg                              156


<210> 9
<211> 156
<212> DNA
<213> Artificial Sequence


<220> 
<223> Recoded p40 promoter 2

<400> 9
gtcaccaagc aggaagtcaa agactttttc cggtgggcaa aggatcacgt ggttgaggtg     60

gagcatgaat tctacgtcaa aaaggggggg gccaagaaaa gacccgcccc cagtgacgca    120

gatataagtg agcccaaacg ggtgcgcgag agtgtg                              156


<210> 10
<211> 37669
<212> DNA
<213> Artificial Sequence


<220> 
<223> cap-rAdV nucleic acid sequence

<220> 
<221> gene
<222> 3330..4121
<223> /gene="kanamycin resistance gene"

<220> 
<221> misc_feature
<222> 4589..4691
<223> /note="left inverted terminal repeat"

<220> 
<221> misc_feature
<222> 4771..4919
<223> /note="encapsidation signal"

<220> 
<221> promoter
<222> 4967..5211
<223> /note="HSV-TK promoter"

<220> 
<221> misc_feature
<222> 5237..5238
<223> /note="splice donor site"

<220> 
<221> misc_feature
<222> 5529..5530
<223> /note="minor splice acceptor site"

<220> 
<221> gene
<222> 5533..7737
<223> /gene="VP open reading frame"

<220> 
<221> gene
<222> 5533..7737
<223> /gene="VP1 gene"

<220> 
<221> misc_feature
<222> 5556..5557
<223> /note="major splice acceptor site"

<220> 
<221> gene
<222> 5944..7737
<223> /gene="VP2 gene"

<220> 
<221> gene
<222> 6139..7737
<223> /gene="VP3 gene"

<220> 
<221> polyA_site
<222> 7754..7758
<223> /note="polyadenylation site"

<220> 
<221> misc_feature
<222> 9920..36680
<223> /note="Ad5 genome (E1/E3 deleted)"

<220> 
<221> variation
<222> 35396

<220> 
<221> misc_feature
<222> 36681..37669
<223> /note="Ad5 left arm homology"

<220> 
<221> variation
<222> 37085

<400> 10
ttaattaaca tgcatggatc ctcgtctcga cgatgccctt gagagccttc aacccagtca        60

gctccttccg gtgggcgcgg ggcatgacta tcgtcgccgc acttatgact gtcttcttta       120

tcatgcaact cgtaggacag gtgccggcag cgctctgggt cattttcggc gaggaccgct       180

ttcgctggag cgcgacgatg atcggcctgt cgcttgcggt attcggaatc ttgcacgccc       240

tcgctcaagc cttcgtcact ggtcccgcca ccaaacgttt cggcgagaag caggccatta       300

tcgccggcat ggcggccgac gcgctgggct acgtcttgct ggcgttcgcg acgcgaggct       360

ggatggcctt ccccattatg attcttctcg cttccggcgg catcgggatg cccgcgttgc       420

aggccatgct gtccaggcag gtagatgacg accatcaggg acagcttcaa ggatcgctcg       480

cggctcttac cagcctaact tcgatcactg gaccgctgat cgtcacggcg atttatgccg       540

cctcggcgag cacatggaac gggttggcat ggattgtagg cgccgcccta taccttgtct       600

gcctccccgc gttgcgtcgc ggtgcatgga gccgggccac ctcgacctga atggaagccg       660

gcggcacctc gctaacggat tcaccactcc aagaattgga gccaatcaat tcttgcggag       720

aactgtgaat gcgcaaacca acccttggca gaacatatcc atcgcgtccg ccatctccag       780

cagccgcacg cggcgcatct cgggcagcgt tgggtcctgg ccacgggtgc gcatgatcgt       840

gctcctgtcg ttgaggaccc ggctaggctg gcggggttgc cttactggtt agcagaatga       900

atcaccgata cgcgagcgaa cgtgaagcga ctgctgctgc aaaacgtctg cgacctgagc       960

aacaacatga atggtcttcg gtttccgtgt ttcgtaaagt ctggaaacgc ggaagtcagc      1020

gccctgcacc attatgttcc ggatctgcat cgcaggatgc tgctggctac cctgtggaac      1080

acctacatct gtattaacga agcgctggca ttgaccctga gtgatttttc tctggtcccg      1140

ccgcatccat accgccagtt gtttaccctc acaacgttcc agtaaccggg catgttcatc      1200

atcagtaacc cgtatcgtga gcatcctctc tcgtttcatc ggtatcatta cccccatgaa      1260

cagaaattcc cccttacacg gaggcatcaa gtgaccaaac aggaaaaaac cgcccttaac      1320

atggcccgct ttatcagaag ccagacatta acgcttctgg agaaactcaa cgagctggac      1380

gcggatgaac aggcagacat ctgtgaatcg cttcacgacc acgctgatga gctttaccgc      1440

agctgcctcg cgcgtttcgg tgatgacggt gaaaacctct gacacatgca gctcccggag      1500

acggtcacag cttgtctgta agcggatgcc gggagcagac aagcccgtca gggcgcgtca      1560

gcgggtgttg gcgggtgtcg gggcgcagcc atgacccagt cacgtagcga tagcggagtg      1620

tatactggct taactatgcg gcatcagagc agattgtact gagagtgcac catatgcggt      1680

gtgaaatacc gcacagatgc gtaaggagaa aataccgcat caggcgctct tccgcttcct      1740

cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa      1800

aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa      1860

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc      1920

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga      1980

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc      2040

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt      2100

ctcaatgctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct      2160

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg      2220

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta      2280

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct      2340

acactagaag gacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa      2400

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt      2460

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta      2520

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat      2580

caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa      2640

gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct      2700

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta      2760

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct      2820

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg      2880

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa      2940

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctgcagcc atgagattat      3000

caaaaaggat cttcacctag atccttttca cgtagaaagc cagtccgcag aaacggtgct      3060

gaccccggat gaatgtcagc tactgggcta tctggacaag ggaaaacgca agcgcaaaga      3120

gaaagcaggt agcttgcagt gggcttacat ggcgatagct agactgggcg gttttatgga      3180

cagcaagcga accggaattg ccagctgggg cgccctctgg taaggttggg aagccctgca      3240

aagtaaactg gatggctttc ttgccgccaa ggatctgatg gcgcagggga tcaagctctg      3300

atcaagagac aggatgagga tcgtttcgca tgattgaaca agatggattg cacgcaggtt      3360

ctccggccgc ttgggtggag aggctattcg gctatgactg ggcacaacag acaatcggct      3420

gctctgatgc cgccgtgttc cggctgtcag cgcaggggcg cccggttctt tttgtcaaga      3480

ccgacctgtc cggtgccctg aatgaactgc aagacgaggc agcgcggcta tcgtggctgg      3540

ccacgacggg cgttccttgc gcagctgtgc tcgacgttgt cactgaagcg ggaagggact      3600

ggctgctatt gggcgaagtg ccggggcagg atctcctgtc atctcacctt gctcctgccg      3660

agaaagtatc catcatggct gatgcaatgc ggcggctgca tacgcttgat ccggctacct      3720

gcccattcga ccaccaagcg aaacatcgca tcgagcgagc acgtactcgg atggaagccg      3780

gtcttgtcga tcaggatgat ctggacgaag agcatcaggg gctcgcgcca gccgaactgt      3840

tcgccaggct caaggcgagc atgcccgacg gcgaggatct cgtcgtgacc catggcgatg      3900

cctgcttgcc gaatatcatg gtggaaaatg gccgcttttc tggattcatc gactgtggcc      3960

ggctgggtgt ggcggaccgc tatcaggaca tagcgttggc tacccgtgat attgctgaag      4020

agcttggcgg cgaatgggct gaccgcttcc tcgtgcttta cggtatcgcc gctcccgatt      4080

cgcagcgcat cgccttctat cgccttcttg acgagttctt ctgaattttg ttaaaatttt      4140

tgttaaatca gctcattttt taaccaatag gccgaaatcg gcaacatccc ttataaatca      4200

aaagaataga ccgcgatagg gttgagtgtt gttccagttt ggaacaagag tccactatta      4260

aagaacgtgg actccaacgt caaagggcga aaaaccgtct atcagggcga tggcccacta      4320

cgtgaaccat cacccaaatc aagttttttg cggtcgaggt gccgtaaagc tctaaatcgg      4380

aaccctaaag ggagcccccg atttagagct tgacggggaa agccggcgaa cgtggcgaga      4440

aaggaaggga agaaagcgaa aggagcgggc gctagggcgc tggcaagtgt agcggtcacg      4500

ctgcgcgtaa ccaccacacc cgcgcgctta atgcgccgct acagggcgcg tccattcgcc      4560

attcaggatc gaattaattc ttaattaaca tcatcaataa tataccttat tttggattga      4620

agccaatatg ataatgaggg ggtggagttt gtgacgtggc gcggggcgtg ggaacggggc      4680

gggtgacgta gtagtgtggc ggaagtgtga tgttgcaagt gtggcggaac acatgtaagc      4740

gacggatgtg gcaaaagtga cgtttttggt gtgcgccggt gtacacagga agtgacaatt      4800

ttcgcgcggt tttaggcgga tgttgtagta aatttgggcg taaccgagta agatttggcc      4860

attttcgcgg gaaaactgaa taagaggaag tgaaatctga ataattttgt gttactcata      4920

gcgcgtaata ctggtaccgc ggccgcctcg agtctagatg actagtctgc ttcatccccg      4980

tggcccgttg ctcgcgtttg ctggcggtgt ccccggaaga aatatatttg catgtcttta      5040

gttctatgat gacacaaacc ccgcccagcg tcttgtcatt ggcgaattcg aacacgcaga      5100

tgcagtcggg gcggcgcggt cccaggtcca cttcgcatat taaggtgacg cgtgtggcct      5160

cgaacaccga gcgaccctgc agcgacccgc ttaacagcgt caacagcgtg caagcttcga      5220

tcaactacgc agacaggtac caaaacaaat gttctcgtca cgtgggcatg aatctgatgc      5280

tgtttccctg cagacaatgc gagagaatga atcagaattc aaatatctgc ttcactcacg      5340

gacagaaaga ctgtttagag tgctttcccg tgtcagaatc tcaacccgtt tctgtcgtca      5400

aaaaggcgta tcagaaactg tgctacattc atcatatcat gggaaaggtg ccagacgctt      5460

gcactgcctg cgatctggtc aatgtggatt tggatgactg catctttgaa caataaatga      5520

tttaaatcag gtatggctgc cgatggttat cttccagatt ggctcgagga cactctctct      5580

gaaggaataa gacagtggtg gaagctcaaa cctggcccac caccaccaaa gcccgcagag      5640

cggcataagg acgacagcag gggtcttgtg cttcctgggt acaagtacct cggacccttc      5700

aacggactcg acaagggaga gccggtcaac gaggcagacg ccgcggccct cgagcacgac      5760

aaagcctacg accggcagct cgacagcgga gacaacccgt acctcaagta caaccacgcc      5820

gacgcggagt ttcaggagcg ccttaaagaa gatacgtctt ttgggggcaa cctcggacga      5880

gcagtcttcc aggcgaaaaa gagggttctt gaacctctgg gcctggttga ggaacctgtt      5940

aagacggctc cgggaaaaaa gaggccggta gagcactctc ctgtggagcc agactcctcc      6000

tcgggaaccg gaaaggcggg ccagcagcct gcaagaaaaa gattgaattt tggtcagact      6060

ggagacgcag actcagtacc tgacccccag cctctcggac agccaccagc agccccctct      6120

ggtctgggaa ctaatacgat ggctacaggc agtggcgcac caatggcaga caataacgag      6180

ggcgccgacg gagtgggtaa ttcctcggga aattggcatt gcgattccac atggatgggc      6240

gacagagtca tcaccaccag cacccgaacc tgggccctgc ccacctacaa caaccacctc      6300

tacaaacaaa tttccagcca atcaggagcc tcgaacgaca atcactactt tggctacagc      6360

accccttggg ggtattttga cttcaacaga ttccactgcc acttttcacc acgtgactgg      6420

caaagactca tcaacaacaa ctggggattc cgacccaaga gactcaactt caagctcttt      6480

aacattcaag tcaaagaggt cacgcagaat gacggtacga cgacgattgc caataacctt      6540

accagcacgg ttcaggtgtt tactgactcg gagtaccagc tcccgtacgt cctcggctcg      6600

gcgcatcaag gatgcctccc gccgttccca gcagacgtct tcatggtgcc acagtatgga      6660

tacctcaccc tgaacaacgg gagtcaggca gtaggacgct cttcatttta ctgcctggag      6720

tactttcctt ctcagatgct gcgtaccgga aacaacttta ccttcagcta cacttttgag      6780

gacgttcctt tccacagcag ctacgctcac agccagagtc tggaccgtct catgaatcct      6840

ctcatcgacc agtacctgta ttacttgagc agaacaaaca ctccaagtgg aaccaccacg      6900

cagtcaaggc ttcagttttc tcaggccgga gcgagtgaca ttcgggacca gtctaggaac      6960

tggcttcctg gaccctgtta ccgccagcag cgagtatcaa agacatctgc ggataacaac      7020

aacagtgaat actcgtggac tggagctacc aagtaccacc tcaatggcag agactctctg      7080

gtgaatccgg gcccggccat ggcaagccac aaggacgatg aagaaaagtt ttttcctcag      7140

agcggggttc tcatctttgg gaagcaaggc tcagagaaaa caaatgtgga cattgaaaag      7200

gtcatgatta cagacgaaga ggaaatcagg acaaccaatc ccgtggctac ggagcagtat      7260

ggttctgtat ctaccaacct ccagagaggc aacagacaag cagctaccgc agatgtcaac      7320

acacaaggcg ttcttccagg catggtctgg caggacagag atgtgtacct tcaggggccc      7380

atctgggcaa agattccaca cacggacgga cattttcacc cctctcccct catgggtgga      7440

ttcggactta aacaccctcc tccacagatt ctcatcaaga acaccccggt acctgcgaat      7500

ccttcgacca ccttcagtgc ggcaaagttt gcttccttca tcacacagta ctccacggga      7560

caggtcagcg tggagatcga gtgggagctg cagaaggaaa acagcaaacg ctggaatccc      7620

gaaattcagt acacttccaa ctacaacaag tctgttaatg tggactttac tgtggacact      7680

aatggcgtgt attcagagcc tcgccccatt ggcaccagat acctgactcg taatctgtaa      7740

ttgcttgtta atcaataaac cgtttaattc gtttcagttg aactttggtc tctgcgtatt      7800

tctttcttat ctagtttcca tggctacgta gataagtagc atggcgggtt aatcattcta      7860

gctagagata tcgaattcaa gctagcttgt cgactcgaag atctgggcgt ggttaagggt      7920

gggaaagaat atataaggtg ggggtcttat gtagttttgt atctgttttg cagcagccgc      7980

cgccgccatg agcaccaact cgtttgatgg aagcattgtg agctcatatt tgacaacgcg      8040

catgccccca tgggccgggg tgcgtcagaa tgtgatgggc tccagcattg atggtcgccc      8100

cgtcctgccc gcaaactcta ctaccttgac ctacgagacc gtgtctggaa cgccgttgga      8160

gactgcagcc tccgccgccg cttcagccgc tgcagccacc gcccgcggga ttgtgactga      8220

ctttgctttc ctgagcccgc ttgcaagcag tgcagcttcc cgttcatccg cccgcgatga      8280

caagttgacg gctcttttgg cacaattgga ttctttgacc cgggaactta atgtcgtttc      8340

tcagcagctg ttggatctgc gccagcaggt ttctgccctg aaggcttcct cccctcccaa      8400

tgcggtttaa aacataaata aaaaaccaga ctctgtttgg atttggatca agcaagtgtc      8460

ttgctgtctt tatttagggg ttttgcgcgc gcggtaggcc cgggaccagc ggtctcggtc      8520

gttgagggtc ctgtgtattt tttccaggac gtggtaaagg tgactctgga tgttcagata      8580

catgggcata agcccgtctc tggggtggag gtagcaccac tgcagagctt catgctgcgg      8640

ggtggtgttg tagatgatcc agtcgtagca ggagcgctgg gcgtggtgcc taaaaatgtc      8700

tttcagtagc aagctgattg ccaggggcag gcccttggtg taagtgttta caaagcggtt      8760

aagctgggat gggtgcatac gtggggatat gagatgcatc ttggactgta tttttaggtt      8820

ggctatgttc ccagccatat ccctccgggg attcatgttg tgcagaacca ccagcacagt      8880

gtatccggtg cacttgggaa atttgtcatg tagcttagaa ggaaatgcgt ggaagaactt      8940

ggagacgccc ttgtgacctc caagattttc catgcattcg tccataatga tggcaatggg      9000

cccacgggcg gcggcctggg cgaagatatt tctgggatca ctaacgtcat agttgtgttc      9060

caggatgaga tcgtcatagg ccatttttac aaagcgcggg cggagggtgc cagactgcgg      9120

tataatggtt ccatccggcc caggggcgta gttaccctca cagatttgca tttcccacgc      9180

tttgagttca gatgggggga tcatgtctac ctgcggggcg atgaagaaaa cggtttccgg      9240

ggtaggggag atcagctggg aagaaagcag gttcctgagc agctgcgact taccgcagcc      9300

ggtgggcccg taaatcacac ctattaccgg gtgcaactgg tagttaagag agctgcagct      9360

gccgtcatcc ctgagcaggg gggccacttc gttaagcatg tccctgactc gcatgttttc      9420

cctgaccaaa tccgccagaa ggcgctcgcc gcccagcgat agcagttctt gcaaggaagc      9480

aaagtttttc aacggtttga gaccgtccgc cgtaggcatg cttttgagcg tttgaccaag      9540

cagttccagg cggtcccaca gctcggtcac ctgctctacg gcatctcgat ccagcatatc      9600

tcctcgtttc gcgggttggg gcggctttcg ctgtacggca gtagtcggtg ctcgtccaga      9660

cgggccaggg tcatgtcttt ccacgggcgc agggtcctcg tcagcgtagt ctgggtcacg      9720

gtgaaggggt gcgctccggg ctgcgcgctg gccagggtgc gcttgaggct ggtcctgctg      9780

gtgctgaagc gctgccggtc ttcgccctgc gcgtcggcca ggtagcattt gaccatggtg      9840

tcatagtcca gcccctccgc ggcgtggccc ttggcgcgca gcttgccctt ggaggaggcg      9900

ccgcacgagg ggcagtgcag acttttgagg gcgtagagct tgggcgcgag aaataccgat      9960

tccggggagt aggcatccgc gccgcaggcc ccgcagacgg tctcgcattc cacgagccag     10020

gtgagctctg gccgttcggg gtcaaaaacc aggtttcccc catgcttttt gatgcgtttc     10080

ttacctctgg tttccatgag ccggtgtcca cgctcggtga cgaaaaggct gtccgtgtcc     10140

ccgtatacag acttgagagg cctgtcctcg agcggtgttc cgcggtcctc ctcgtataga     10200

aactcggacc actctgagac aaaggctcgc gtccaggcca gcacgaagga ggctaagtgg     10260

gaggggtagc ggtcgttgtc cactaggggg tccactcgct ccagggtgtg aagacacatg     10320

tcgccctctt cggcatcaag gaaggtgatt ggtttgtagg tgtaggccac gtgaccgggt     10380

gttcctgaag gggggctata aaagggggtg ggggcgcgtt cgtcctcact ctcttccgca     10440

tcgctgtctg cgagggccag ctgttggggt gagtactccc tctgaaaagc gggcatgact     10500

tctgcgctaa gattgtcagt ttccaaaaac gaggaggatt tgatattcac ctggcccgcg     10560

gtgatgcctt tgagggtggc cgcatccatc tggtcagaaa agacaatctt tttgttgtca     10620

agcttggtgg caaacgaccc gtagagggcg ttggacagca acttggcgat ggagcgcagg     10680

gtttggtttt tgtcgcgatc ggcgcgctcc ttggccgcga tgtttagctg cacgtattcg     10740

cgcgcaacgc accgccattc gggaaagacg gtggtgcgct cgtcgggcac caggtgcacg     10800

cgccaaccgc ggttgtgcag ggtgacaagg tcaacgctgg tggctacctc tccgcgtagg     10860

cgctcgttgg tccagcagag gcggccgccc ttgcgcgagc agaatggcgg tagggggtct     10920

agctgcgtct cgtccggggg gtctgcgtcc acggtaaaga ccccgggcag caggcgcgcg     10980

tcgaagtagt ctatcttgca tccttgcaag tctagcgcct gctgccatgc gcgggcggca     11040

agcgcgcgct cgtatgggtt gagtggggga ccccatggca tggggtgggt gagcgcggag     11100

gcgtacatgc cgcaaatgtc gtaaacgtag aggggctctc tgagtattcc aagatatgta     11160

gggtagcatc ttccaccgcg gatgctggcg cgcacgtaat cgtatagttc gtgcgaggga     11220

gcgaggaggt cgggaccgag gttgctacgg gcgggctgct ctgctcggaa gactatctgc     11280

ctgaagatgg catgtgagtt ggatgatatg gttggacgct ggaagacgtt gaagctggcg     11340

tctgtgagac ctaccgcgtc acgcacgaag gaggcgtagg agtcgcgcag cttgttgacc     11400

agctcggcgg tgacctgcac gtctagggcg cagtagtcca gggtttcctt gatgatgtca     11460

tacttatcct gtcccttttt tttccacagc tcgcggttga ggacaaactc ttcgcggtct     11520

ttccagtact cttggatcgg aaacccgtcg gcctccgaac ggtaagagcc tagcatgtag     11580

aactggttga cggcctggta ggcgcagcat cccttttcta cgggtagcgc gtatgcctgc     11640

gcggccttcc ggagcgaggt gtgggtgagc gcaaaggtgt ccctgaccat gactttgagg     11700

tactggtatt tgaagtcagt gtcgtcgcat ccgccctgct cccagagcaa aaagtccgtg     11760

cgctttttgg aacgcggatt tggcagggcg aaggtgacat cgttgaagag tatctttccc     11820

gcgcgaggca taaagttgcg tgtgatgcgg aagggtcccg gcacctcgga acggttgtta     11880

attacctggg cggcgagcac gatctcgtca aagccgttga tgttgtggcc cacaatgtaa     11940

agttccaaga agcgcgggat gcccttgatg gaaggcaatt ttttaagttc ctcgtaggtg     12000

agctcttcag gggagctgag cccgtgctct gaaagggccc agtctgcaag atgagggttg     12060

gaagcgacga atgagctcca caggtcacgg gccattagca tttgcaggtg gtcgcgaaag     12120

gtcctaaact ggcgacctat ggccattttt tctggggtga tgcagtagaa ggtaagcggg     12180

tcttgttccc agcggtccca tccaaggttc gcggctaggt ctcgcgcggc agtcactaga     12240

ggctcatctc cgccgaactt catgaccagc atgaagggca cgagctgctt cccaaaggcc     12300

cccatccaag tataggtctc tacatcgtag gtgacaaaga gacgctcggt gcgaggatgc     12360

gagccgatcg ggaagaactg gatctcccgc caccaattgg aggagtggct attgatgtgg     12420

tgaaagtaga agtccctgcg acgggccgaa cactcgtgct ggcttttgta aaaacgtgcg     12480

cagtactggc agcggtgcac gggctgtaca tcctgcacga ggttgacctg acgaccgcgc     12540

acaaggaagc agagtgggaa tttgagcccc tcgcctggcg ggtttggctg gtggtcttct     12600

acttcggctg cttgtccttg accgtctggc tgctcgaggg gagttacggt ggatcggacc     12660

accacgccgc gcgagcccaa agtccagatg tccgcgcgcg gcggtcggag cttgatgaca     12720

acatcgcgca gatgggagct gtccatggtc tggagctccc gcggcgtcag gtcaggcggg     12780

agctcctgca ggtttacctc gcatagacgg gtcagggcgc gggctagatc caggtgatac     12840

ctaatttcca ggggctggtt ggtggcggcg tcgatggctt gcaagaggcc gcatccccgc     12900

ggcgcgacta cggtaccgcg cggcgggcgg tgggccgcgg gggtgtcctt ggatgatgca     12960

tctaaaagcg gtgacgcggg cgagcccccg gaggtagggg gggctccgga cccgccggga     13020

gagggggcag gggcacgtcg gcgccgcgcg cgggcaggag ctggtgctgc gcgcgtaggt     13080

tgctggcgaa cgcgacgacg cggcggttga tctcctgaat ctggcgcctc tgcgtgaaga     13140

cgacgggccc ggtgagcttg agcctgaaag agagttcgac agaatcaatt tcggtgtcgt     13200

tgacggcggc ctggcgcaaa atctcctgca cgtctcctga gttgtcttga taggcgatct     13260

cggccatgaa ctgctcgatc tcttcctcct ggagatctcc gcgtccggct cgctccacgg     13320

tggcggcgag gtcgttggaa atgcgggcca tgagctgcga gaaggcgttg aggcctccct     13380

cgttccagac gcggctgtag accacgcccc cttcggcatc gcgggcgcgc atgaccacct     13440

gcgcgagatt gagctccacg tgccgggcga agacggcgta gtttcgcagg cgctgaaaga     13500

ggtagttgag ggtggtggcg gtgtgttctg ccacgaagaa gtacataacc cagcgtcgca     13560

acgtggattc gttgatatcc cccaaggcct caaggcgctc catggcctcg tagaagtcca     13620

cggcgaagtt gaaaaactgg gagttgcgcg ccgacacggt taactcctcc tccagaagac     13680

ggatgagctc ggcgacagtg tcgcgcacct cgcgctcaaa ggctacaggg gcctcttctt     13740

cttcttcaat ctcctcttcc ataagggcct ccccttcttc ttcttctggc ggcggtgggg     13800

gaggggggac acggcggcga cgacggcgca ccgggaggcg gtcgacaaag cgctcgatca     13860

tctccccgcg gcgacggcgc atggtctcgg tgacggcgcg gccgttctcg cgggggcgca     13920

gttggaagac gccgcccgtc atgtcccggt tatgggttgg cggggggctg ccatgcggca     13980

gggatacggc gctaacgatg catctcaaca attgttgtgt aggtactccg ccgccgaggg     14040

acctgagcga gtccgcatcg accggatcgg aaaacctctc gagaaaggcg tctaaccagt     14100

cacagtcgca aggtaggctg agcaccgtgg cgggcggcag cgggcggcgg tcggggttgt     14160

ttctggcgga ggtgctgctg atgatgtaat taaagtaggc ggtcttgaga cggcggatgg     14220

tcgacagaag caccatgtcc ttgggtccgg cctgctgaat gcgcaggcgg tcggccatgc     14280

cccaggcttc gttttgacat cggcgcaggt ctttgtagta gtcttgcatg agcctttcta     14340

ccggcacttc ttcttctcct tcctcttgtc ctgcatctct tgcatctatc gctgcggcgg     14400

cggcggagtt tggccgtagg tggcgccctc ttcctcccat gcgtgtgacc ccgaagcccc     14460

tcatcggctg aagcagggct aggtcggcga caacgcgctc ggctaatatg gcctgctgca     14520

cctgcgtgag ggtagactgg aagtcatcca tgtccacaaa gcggtggtat gcgcccgtgt     14580

tgatggtgta agtgcagttg gccataacgg accagttaac ggtctggtga cccggctgcg     14640

agagctcggt gtacctgaga cgcgagtaag ccctcgagtc aaatacgtag tcgttgcaag     14700

tccgcaccag gtactggtat cccaccaaaa agtgcggcgg cggctggcgg tagaggggcc     14760

agcgtagggt ggccggggct ccgggggcga gatcttccaa cataaggcga tgatatccgt     14820

agatgtacct ggacatccag gtgatgccgg cggcggtggt ggaggcgcgc ggaaagtcgc     14880

ggacgcggtt ccagatgttg cgcagcggca aaaagtgctc catggtcggg acgctctggc     14940

cggtcaggcg cgcgcaatcg ttgacgctct accgtgcaaa aggagagcct gtaagcgggc     15000

actcttccgt ggtctggtgg ataaattcgc aagggtatca tggcggacga ccggggttcg     15060

agccccgtat ccggccgtcc gccgtgatcc atgcggttac cgcccgcgtg tcgaacccag     15120

gtgtgcgacg tcagacaacg ggggagtgct ccttttggct tccttccagg cgcggcggct     15180

gctgcgctag cttttttggc cactggccgc gcgcagcgta agcggttagg ctggaaagcg     15240

aaagcattaa gtggctcgct ccctgtagcc ggagggttat tttccaaggg ttgagtcgcg     15300

ggacccccgg ttcgagtctc ggaccggccg gactgcggcg aacgggggtt tgcctccccg     15360

tcatgcaaga ccccgcttgc aaattcctcc ggaaacaggg acgagcccct tttttgcttt     15420

tcccagatgc atccggtgct gcggcagatg cgcccccctc ctcagcagcg gcaagagcaa     15480

gagcagcggc agacatgcag ggcaccctcc cctcctccta ccgcgtcagg aggggcgaca     15540

tccgcggttg acgcggcagc agatggtgat tacgaacccc cgcggcgccg ggcccggcac     15600

tacctggact tggaggaggg cgagggcctg gcgcggctag gagcgccctc tcctgagcgg     15660

tacccaaggg tgcagctgaa gcgtgatacg cgtgaggcgt acgtgccgcg gcagaacctg     15720

tttcgcgacc gcgagggaga ggagcccgag gagatgcggg atcgaaagtt ccacgcaggg     15780

cgcgagctgc ggcatggcct gaatcgcgag cggttgctgc gcgaggagga ctttgagccc     15840

gacgcgcgaa ccgggattag tcccgcgcgc gcacacgtgg cggccgccga cctggtaacc     15900

gcatacgagc agacggtgaa ccaggagatt aactttcaaa aaagctttaa caaccacgtg     15960

cgtacgcttg tggcgcgcga ggaggtggct ataggactga tgcatctgtg ggactttgta     16020

agcgcgctgg agcaaaaccc aaatagcaag ccgctcatgg cgcagctgtt ccttatagtg     16080

cagcacagca gggacaacga ggcattcagg gatgcgctgc taaacatagt agagcccgag     16140

ggccgctggc tgctcgattt gataaacatc ctgcagagca tagtggtgca ggagcgcagc     16200

ttgagcctgg ctgacaaggt ggccgccatc aactattcca tgcttagcct gggcaagttt     16260

tacgcccgca agatatacca taccccttac gttcccatag acaaggaggt aaagatcgag     16320

gggttctaca tgcgcatggc gctgaaggtg cttaccttga gcgacgacct gggcgtttat     16380

cgcaacgagc gcatccacaa ggccgtgagc gtgagccggc ggcgcgagct cagcgaccgc     16440

gagctgatgc acagcctgca aagggccctg gctggcacgg gcagcggcga tagagaggcc     16500

gagtcctact ttgacgcggg cgctgacctg cgctgggccc caagccgacg cgccctggag     16560

gcagctgggg ccggacctgg gctggcggtg gcacccgcgc gcgctggcaa cgtcggcggc     16620

gtggaggaat atgacgagga cgatgagtac gagccagagg acggcgagta ctaagcggtg     16680

atgtttctga tcagatgatg caagacgcaa cggacccggc ggtgcgggcg gcgctgcaga     16740

gccagccgtc cggccttaac tccacggacg actggcgcca ggtcatggac cgcatcatgt     16800

cgctgactgc gcgcaatcct gacgcgttcc ggcagcagcc gcaggccaac cggctctccg     16860

caattctgga agcggtggtc ccggcgcgcg caaaccccac gcacgagaag gtgctggcga     16920

tcgtaaacgc gctggccgaa aacagggcca tccggcccga cgaggccggc ctggtctacg     16980

acgcgctgct tcagcgcgtg gctcgttaca acagcggcaa cgtgcagacc aacctggacc     17040

ggctggtggg ggatgtgcgc gaggccgtgg cgcagcgtga gcgcgcgcag cagcagggca     17100

acctgggctc catggttgca ctaaacgcct tcctgagtac acagcccgcc aacgtgccgc     17160

ggggacagga ggactacacc aactttgtga gcgcactgcg gctaatggtg actgagacac     17220

cgcaaagtga ggtgtaccag tctgggccag actatttttt ccagaccagt agacaaggcc     17280

tgcagaccgt aaacctgagc caggctttca aaaacttgca ggggctgtgg ggggtgcggg     17340

ctcccacagg cgaccgcgcg accgtgtcta gcttgctgac gcccaactcg cgcctgttgc     17400

tgctgctaat agcgcccttc acggacagtg gcagcgtgtc ccgggacaca tacctaggtc     17460

acttgctgac actgtaccgc gaggccatag gtcaggcgca tgtggacgag catactttcc     17520

aggagattac aagtgtcagc cgcgcgctgg ggcaggagga cacgggcagc ctggaggcaa     17580

ccctaaacta cctgctgacc aaccggcggc agaagatccc ctcgttgcac agtttaaaca     17640

gcgaggagga gcgcattttg cgctacgtgc agcagagcgt gagccttaac ctgatgcgcg     17700

acggggtaac gcccagcgtg gcgctggaca tgaccgcgcg caacatggaa ccgggcatgt     17760

atgcctcaaa ccggccgttt atcaaccgcc taatggacta cttgcatcgc gcggccgccg     17820

tgaaccccga gtatttcacc aatgccatct tgaacccgca ctggctaccg ccccctggtt     17880

tctacaccgg gggattcgag gtgcccgagg gtaacgatgg attcctctgg gacgacatag     17940

acgacagcgt gttttccccg caaccgcaga ccctgctaga gttgcaacag cgcgagcagg     18000

cagaggcggc gctgcgaaag gaaagcttcc gcaggccaag cagcttgtcc gatctaggcg     18060

ctgcggcccc gcggtcagat gctagtagcc catttccaag cttgataggg tctcttacca     18120

gcactcgcac cacccgcccg cgcctgctgg gcgaggagga gtacctaaac aactcgctgc     18180

tgcagccgca gcgcgaaaaa aacctgcctc cggcatttcc caacaacggg atagagagcc     18240

tagtggacaa gatgagtaga tggaagacgt acgcgcagga gcacagggac gtgccaggcc     18300

cgcgcccgcc cacccgtcgt caaaggcacg accgtcagcg gggtctggtg tgggaggacg     18360

atgactcggc agacgacagc agcgtcctgg atttgggagg gagtggcaac ccgtttgcgc     18420

accttcgccc caggctgggg agaatgtttt aaaaaaaaaa aagcatgatg caaaataaaa     18480

aactcaccaa ggccatggca ccgagcgttg gttttcttgt attcccctta gtatgcggcg     18540

cgcggcgatg tatgaggaag gtcctcctcc ctcctacgag agtgtggtga gcgcggcgcc     18600

agtggcggcg gcgctgggtt ctcccttcga tgctcccctg gacccgccgt ttgtgcctcc     18660

gcggtacctg cggcctaccg gggggagaaa cagcatccgt tactctgagt tggcacccct     18720

attcgacacc acccgtgtgt acctggtgga caacaagtca acggatgtgg catccctgaa     18780

ctaccagaac gaccacagca actttctgac cacggtcatt caaaacaatg actacagccc     18840

gggggaggca agcacacaga ccatcaatct tgacgaccgg tcgcactggg gcggcgacct     18900

gaaaaccatc ctgcatacca acatgccaaa tgtgaacgag ttcatgttta ccaataagtt     18960

taaggcgcgg gtgatggtgt cgcgcttgcc tactaaggac aatcaggtgg agctgaaata     19020

cgagtgggtg gagttcacgc tgcccgaggg caactactcc gagaccatga ccatagacct     19080

tatgaacaac gcgatcgtgg agcactactt gaaagtgggc agacagaacg gggttctgga     19140

aagcgacatc ggggtaaagt ttgacacccg caacttcaga ctggggtttg accccgtcac     19200

tggtcttgtc atgcctgggg tatatacaaa cgaagccttc catccagaca tcattttgct     19260

gccaggatgc ggggtggact tcacccacag ccgcctgagc aacttgttgg gcatccgcaa     19320

gcggcaaccc ttccaggagg gctttaggat cacctacgat gatctggagg gtggtaacat     19380

tcccgcactg ttggatgtgg acgcctacca ggcgagcttg aaagatgaca ccgaacaggg     19440

cgggggtggc gcaggcggca gcaacagcag tggcagcggc gcggaagaga actccaacgc     19500

ggcagccgcg gcaatgcagc cggtggagga catgaacgat catgccattc gcggcgacac     19560

ctttgccaca cgggctgagg agaagcgcgc tgaggccgaa gcagcggccg aagctgccgc     19620

ccccgctgcg caacccgagg tcgagaagcc tcagaagaaa ccggtgatca aacccctgac     19680

agaggacagc aagaaacgca gttacaacct aataagcaat gacagcacct tcacccagta     19740

ccgcagctgg taccttgcat acaactacgg cgaccctcag accggaatcc gctcatggac     19800

cctgctttgc actcctgacg taacctgcgg ctcggagcag gtctactggt cgttgccaga     19860

catgatgcaa gaccccgtga ccttccgctc cacgcgccag atcagcaact ttccggtggt     19920

gggcgccgag ctgttgcccg tgcactccaa gagcttctac aacgaccagg ccgtctactc     19980

ccaactcatc cgccagttta cctctctgac ccacgtgttc aatcgctttc ccgagaacca     20040

gattttggcg cgcccgccag cccccaccat caccaccgtc agtgaaaacg ttcctgctct     20100

cacagatcac gggacgctac cgctgcgcaa cagcatcgga ggagtccagc gagtgaccat     20160

tactgacgcc agacgccgca cctgccccta cgtttacaag gccctgggca tagtctcgcc     20220

gcgcgtccta tcgagccgca ctttttgagc aagcatgtcc atccttatat cgcccagcaa     20280

taacacaggc tggggcctgc gcttcccaag caagatgttt ggcggggcca agaagcgctc     20340

cgaccaacac ccagtgcgcg tgcgcgggca ctaccgcgcg ccctggggcg cgcacaaacg     20400

cggccgcact gggcgcacca ccgtcgatga cgccatcgac gcggtggtgg aggaggcgcg     20460

caactacacg cccacgccgc caccagtgtc cacagtggac gcggccattc agaccgtggt     20520

gcgcggagcc cggcgctatg ctaaaatgaa gagacggcgg aggcgcgtag cacgtcgcca     20580

ccgccgccga cccggcactg ccgcccaacg cgcggcggcg gccctgctta accgcgcacg     20640

tcgcaccggc cgacgggcgg ccatgcgggc cgctcgaagg ctggccgcgg gtattgtcac     20700

tgtgcccccc aggtccaggc gacgagcggc cgccgcagca gccgcggcca ttagtgctat     20760

gactcagggt cgcaggggca acgtgtattg ggtgcgcgac tcggttagcg gcctgcgcgt     20820

gcccgtgcgc acccgccccc cgcgcaacta gattgcaaga aaaaactact tagactcgta     20880

ctgttgtatg tatccagcgg cggcggcgcg caacgaagct atgtccaagc gcaaaatcaa     20940

agaagagatg ctccaggtca tcgcgccgga gatctatggc cccccgaaga aggaagagca     21000

ggattacaag ccccgaaagc taaagcgggt caaaaagaaa aagaaagatg atgatgatga     21060

acttgacgac gaggtggaac tgctgcacgc taccgcgccc aggcgacggg tacagtggaa     21120

aggtcgacgc gtaaaacgtg ttttgcgacc cggcaccacc gtagtcttta cgcccggtga     21180

gcgctccacc cgcacctaca agcgcgtgta tgatgaggtg tacggcgacg aggacctgct     21240

tgagcaggcc aacgagcgcc tcggggagtt tgcctacgga aagcggcata aggacatgct     21300

ggcgttgccg ctggacgagg gcaacccaac acctagccta aagcccgtaa cactgcagca     21360

ggtgctgccc gcgcttgcac cgtccgaaga aaagcgcggc ctaaagcgcg agtctggtga     21420

cttggcaccc accgtgcagc tgatggtacc caagcgccag cgactggaag atgtcttgga     21480

aaaaatgacc gtggaacctg ggctggagcc cgaggtccgc gtgcggccaa tcaagcaggt     21540

ggcgccggga ctgggcgtgc agaccgtgga cgttcagata cccactacca gtagcaccag     21600

tattgccacc gccacagagg gcatggagac acaaacgtcc ccggttgcct cagcggtggc     21660

ggatgccgcg gtgcaggcgg tcgctgcggc cgcgtccaag acctctacgg aggtgcaaac     21720

ggacccgtgg atgtttcgcg tttcagcccc ccggcgcccg cgcggttcga ggaagtacgg     21780

cgccgccagc gcgctactgc ccgaatatgc cctacatcct tccattgcgc ctacccccgg     21840

ctatcgtggc tacacctacc gccccagaag acgagcaact acccgacgcc gaaccaccac     21900

tggaacccgc cgccgccgtc gccgtcgcca gcccgtgctg gccccgattt ccgtgcgcag     21960

ggtggctcgc gaaggaggca ggaccctggt gctgccaaca gcgcgctacc accccagcat     22020

cgtttaaaag ccggtctttg tggttcttgc agatatggcc ctcacctgcc gcctccgttt     22080

cccggtgccg ggattccgag gaagaatgca ccgtaggagg ggcatggccg gccacggcct     22140

gacgggcggc atgcgtcgtg cgcaccaccg gcggcggcgc gcgtcgcacc gtcgcatgcg     22200

cggcggtatc ctgcccctcc ttattccact gatcgccgcg gcgattggcg ccgtgcccgg     22260

aattgcatcc gtggccttgc aggcgcagag acactgatta aaaacaagtt gcatgtggaa     22320

aaatcaaaat aaaaagtctg gactctcacg ctcgcttggt cctgtaacta ttttgtagaa     22380

tggaagacat caactttgcg tctctggccc cgcgacacgg ctcgcgcccg ttcatgggaa     22440

actggcaaga tatcggcacc agcaatatga gcggtggcgc cttcagctgg ggctcgctgt     22500

ggagcggcat taaaaatttc ggttccaccg ttaagaacta tggcagcaag gcctggaaca     22560

gcagcacagg ccagatgctg agggataagt tgaaagagca aaatttccaa caaaaggtgg     22620

tagatggcct ggcctctggc attagcgggg tggtggacct ggccaaccag gcagtgcaaa     22680

ataagattaa cagtaagctt gatccccgcc ctcccgtaga ggagcctcca ccggccgtgg     22740

agacagtgtc tccagagggg cgtggcgaaa agcgtccgcg ccccgacagg gaagaaactc     22800

tggtgacgca aatagacgag cctccctcgt acgaggaggc actaaagcaa ggcctgccca     22860

ccacccgtcc catcgcgccc atggctaccg gagtgctggg ccagcacaca cccgtaacgc     22920

tggacctgcc tccccccgcc gacacccagc agaaacctgt gctgccaggc ccgaccgccg     22980

ttgttgtaac ccgtcctagc cgcgcgtccc tgcgccgcgc cgccagcggt ccgcgatcgt     23040

tgcggcccgt agccagtggc aactggcaaa gcacactgaa cagcatcgtg ggtctggggg     23100

tgcaatccct gaagcgccga cgatgcttct gaatagctaa cgtgtcgtat gtgtgtcatg     23160

tatgcgtcca tgtcgccgcc agaggagctg ctgagccgcc gcgcgcccgc tttccaagat     23220

ggctacccct tcgatgatgc cgcagtggtc ttacatgcac atctcgggcc aggacgcctc     23280

ggagtacctg agccccgggc tggtgcagtt tgcccgcgcc accgagacgt acttcagcct     23340

gaataacaag tttagaaacc ccacggtggc gcctacgcac gacgtgacca cagaccggtc     23400

ccagcgtttg acgctgcggt tcatccctgt ggaccgtgag gatactgcgt actcgtacaa     23460

ggcgcggttc accctagctg tgggtgataa ccgtgtgctg gacatggctt ccacgtactt     23520

tgacatccgc ggcgtgctgg acaggggccc tacttttaag ccctactctg gcactgccta     23580

caacgccctg gctcccaagg gtgccccaaa tccttgcgaa tgggatgaag ctgctactgc     23640

tcttgaaata aacctagaag aagaggacga tgacaacgaa gacgaagtag acgagcaagc     23700

tgagcagcaa aaaactcacg tatttgggca ggcgccttat tctggtataa atattacaaa     23760

ggagggtatt caaataggtg tcgaaggtca aacacctaaa tatgccgata aaacatttca     23820

acctgaacct caaataggag aatctcagtg gtacgaaact gaaattaatc atgcagctgg     23880

gagagtcctt aaaaagacta ccccaatgaa accatgttac ggttcatatg caaaacccac     23940

aaatgaaaat ggagggcaag gcattcttgt aaagcaacaa aatggaaagc tagaaagtca     24000

agtggaaatg caatttttct caactactga ggcgaccgca ggcaatggtg ataacttgac     24060

tcctaaagtg gtattgtaca gtgaagatgt agatatagaa accccagaca ctcatatttc     24120

ttacatgccc actattaagg aaggtaactc acgagaacta atgggccaac aatctatgcc     24180

caacaggcct aattacattg cttttaggga caattttatt ggtctaatgt attacaacag     24240

cacgggtaat atgggtgttc tggcgggcca agcatcgcag ttgaatgctg ttgtagattt     24300

gcaagacaga aacacagagc tttcatacca gcttttgctt gattccattg gtgatagaac     24360

caggtacttt tctatgtgga atcaggctgt tgacagctat gatccagatg ttagaattat     24420

tgaaaatcat ggaactgaag atgaacttcc aaattactgc tttccactgg gaggtgtgat     24480

taatacagag actcttacca aggtaaaacc taaaacaggt caggaaaatg gatgggaaaa     24540

agatgctaca gaattttcag ataaaaatga aataagagtt ggaaataatt ttgccatgga     24600

aatcaatcta aatgccaacc tgtggagaaa tttcctgtac tccaacatag cgctgtattt     24660

gcccgacaag ctaaagtaca gtccttccaa cgtaaaaatt tctgataacc caaacaccta     24720

cgactacatg aacaagcgag tggtggctcc cgggttagtg gactgctaca ttaaccttgg     24780

agcacgctgg tcccttgact atatggacaa cgtcaaccca tttaaccacc accgcaatgc     24840

tggcctgcgc taccgctcaa tgttgctggg caatggtcgc tatgtgccct tccacatcca     24900

ggtgcctcag aagttctttg ccattaaaaa cctccttctc ctgccgggct catacaccta     24960

cgagtggaac ttcaggaagg atgttaacat ggttctgcag agctccctag gaaatgacct     25020

aagggttgac ggagccagca ttaagtttga tagcatttgc ctttacgcca ccttcttccc     25080

catggcccac aacaccgcct ccacgcttga ggccatgctt agaaacgaca ccaacgacca     25140

gtcctttaac gactatctct ccgccgccaa catgctctac cctatacccg ccaacgctac     25200

caacgtgccc atatccatcc cctcccgcaa ctgggcggct ttccgcggct gggccttcac     25260

gcgccttaag actaaggaaa ccccatcact gggctcgggc tacgaccctt attacaccta     25320

ctctggctct ataccctacc tagatggaac cttttacctc aaccacacct ttaagaaggt     25380

ggccattacc tttgactctt ctgtcagctg gcctggcaat gaccgcctgc ttacccccaa     25440

cgagtttgaa attaagcgct cagttgacgg ggagggttac aacgttgccc agtgtaacat     25500

gaccaaagac tggttcctgg tacaaatgct agctaactac aacattggct accagggctt     25560

ctatatccca gagagctaca aggaccgcat gtactccttc tttagaaact tccagcccat     25620

gagccgtcag gtggtggatg atactaaata caaggactac caacaggtgg gcatcctaca     25680

ccaacacaac aactctggat ttgttggcta ccttgccccc accatgcgcg aaggacaggc     25740

ctaccctgct aacttcccct atccgcttat aggcaagacc gcagttgaca gcattaccca     25800

gaaaaagttt ctttgcgatc gcaccctttg gcgcatccca ttctccagta actttatgtc     25860

catgggcgca ctcacagacc tgggccaaaa ccttctctac gccaactccg cccacgcgct     25920

agacatgact tttgaggtgg atcccatgga cgagcccacc cttctttatg ttttgtttga     25980

agtctttgac gtggtccgtg tgcaccggcc gcaccgcggc gtcatcgaaa ccgtgtacct     26040

gcgcacgccc ttctcggccg gcaacgccac aacataaaga agcaagcaac atcaacaaca     26100

gctgccgcca tgggctccag tgagcaggaa ctgaaagcca ttgtcaaaga tcttggttgt     26160

gggccatatt ttttgggcac ctatgacaag cgctttccag gctttgtttc tccacacaag     26220

ctcgcctgcg ccatagtcaa tacggccggt cgcgagactg ggggcgtaca ctggatggcc     26280

tttgcctgga acccgcactc aaaaacatgc tacctctttg agccctttgg cttttctgac     26340

cagcgactca agcaggttta ccagtttgag tacgagtcac tcctgcgccg tagcgccatt     26400

gcttcttccc ccgaccgctg tataacgctg gaaaagtcca cccaaagcgt acaggggccc     26460

aactcggccg cctgtggact attctgctgc atgtttctcc acgcctttgc caactggccc     26520

caaactccca tggatcacaa ccccaccatg aaccttatta ccggggtacc caactccatg     26580

ctcaacagtc cccaggtaca gcccaccctg cgtcgcaacc aggaacagct ctacagcttc     26640

ctggagcgcc actcgcccta cttccgcagc cacagtgcgc agattaggag cgccacttct     26700

ttttgtcact tgaaaaacat gtaaaaataa tgtactagag acactttcaa taaaggcaaa     26760

tgcttttatt tgtacactct cgggtgatta tttaccccca cccttgccgt ctgcgccgtt     26820

taaaaatcaa aggggttctg ccgcgcatcg ctatgcgcca ctggcaggga cacgttgcga     26880

tactggtgtt tagtgctcca cttaaactca ggcacaacca tccgcggcag ctcggtgaag     26940

ttttcactcc acaggctgcg caccatcacc aacgcgttta gcaggtcggg cgccgatatc     27000

ttgaagtcgc agttggggcc tccgccctgc gcgcgcgagt tgcgatacac agggttgcag     27060

cactggaaca ctatcagcgc cgggtggtgc acgctggcca gcacgctctt gtcggagatc     27120

agatccgcgt ccaggtcctc cgcgttgctc agggcgaacg gagtcaactt tggtagctgc     27180

cttcccaaaa agggcgcgtg cccaggcttt gagttgcact cgcaccgtag tggcatcaaa     27240

aggtgaccgt gcccggtctg ggcgttagga tacagcgcct gcataaaagc cttgatctgc     27300

ttaaaagcca cctgagcctt tgcgccttca gagaagaaca tgccgcaaga cttgccggaa     27360

aactgattgg ccggacaggc cgcgtcgtgc acgcagcacc ttgcgtcggt gttggagatc     27420

tgcaccacat ttcggcccca ccggttcttc acgatcttgg ccttgctaga ctgctccttc     27480

agcgcgcgct gcccgttttc gctcgtcaca tccatttcaa tcacgtgctc cttatttatc     27540

ataatgcttc cgtgtagaca cttaagctcg ccttcgatct cagcgcagcg gtgcagccac     27600

aacgcgcagc ccgtgggctc gtgatgcttg taggtcacct ctgcaaacga ctgcaggtac     27660

gcctgcagga atcgccccat catcgtcaca aaggtcttgt tgctggtgaa ggtcagctgc     27720

aacccgcggt gctcctcgtt cagccaggtc ttgcatacgg ccgccagagc ttccacttgg     27780

tcaggcagta gtttgaagtt cgcctttaga tcgttatcca cgtggtactt gtccatcagc     27840

gcgcgcgcag cctccatgcc cttctcccac gcagacacga tcggcacact cagcgggttc     27900

atcaccgtaa tttcactttc cgcttcgctg ggctcttcct cttcctcttg cgtccgcata     27960

ccacgcgcca ctgggtcgtc ttcattcagc cgccgcactg tgcgcttacc tcctttgcca     28020

tgcttgatta gcaccggtgg gttgctgaaa cccaccattt gtagcgccac atcttctctt     28080

tcttcctcgc tgtccacgat tacctctggt gatggcgggc gctcgggctt gggagaaggg     28140

cgcttctttt tcttcttggg cgcaatggcc aaatccgccg ccgaggtcga tggccgcggg     28200

ctgggtgtgc gcggcaccag cgcgtcttgt gatgagtctt cctcgtcctc ggactcgata     28260

cgccgcctca tccgcttttt tgggggcgcc cggggaggcg gcggcgacgg ggacggggac     28320

gacacgtcct ccatggttgg gggacgtcgc gccgcaccgc gtccgcgctc gggggtggtt     28380

tcgcgctgct cctcttcccg actggccatt tccttctcct ataggcagaa aaagatcatg     28440

gagtcagtcg agaagaagga cagcctaacc gccccctctg agttcgccac caccgcctcc     28500

accgatgccg ccaacgcgcc taccaccttc cccgtcgagg cacccccgct tgaggaggag     28560

gaagtgatta tcgagcagga cccaggtttt gtaagcgaag acgacgagga ccgctcagta     28620

ccaacagagg ataaaaagca agaccaggac aacgcagagg caaacgagga acaagtcggg     28680

cggggggacg aaaggcatgg cgactaccta gatgtgggag acgacgtgct gttgaagcat     28740

ctgcagcgcc agtgcgccat tatctgcgac gcgttgcaag agcgcagcga tgtgcccctc     28800

gccatagcgg atgtcagcct tgcctacgaa cgccacctat tctcaccgcg cgtacccccc     28860

aaacgccaag aaaacggcac atgcgagccc aacccgcgcc tcaacttcta ccccgtattt     28920

gccgtgccag aggtgcttgc cacctatcac atctttttcc aaaactgcaa gataccccta     28980

tcctgccgtg ccaaccgcag ccgagcggac aagcagctgg ccttgcggca gggcgctgtc     29040

atacctgata tcgcctcgct caacgaagtg ccaaaaatct ttgagggtct tggacgcgac     29100

gagaagcgcg cggcaaacgc tctgcaacag gaaaacagcg aaaatgaaag tcactctgga     29160

gtgttggtgg aactcgaggg tgacaacgcg cgcctagccg tactaaaacg cagcatcgag     29220

gtcacccact ttgcctaccc ggcacttaac ctacccccca aggtcatgag cacagtcatg     29280

agtgagctga tcgtgcgccg tgcgcagccc ctggagaggg atgcaaattt gcaagaacaa     29340

acagaggagg gcctacccgc agttggcgac gagcagctag cgcgctggct tcaaacgcgc     29400

gagcctgccg acttggagga gcgacgcaaa ctaatgatgg ccgcagtgct cgttaccgtg     29460

gagcttgagt gcatgcagcg gttctttgct gacccggaga tgcagcgcaa gctagaggaa     29520

acattgcact acacctttcg acagggctac gtacgccagg cctgcaagat ctccaacgtg     29580

gagctctgca acctggtctc ctaccttgga attttgcacg aaaaccgcct tgggcaaaac     29640

gtgcttcatt ccacgctcaa gggcgaggcg cgccgcgact acgtccgcga ctgcgtttac     29700

ttatttctat gctacacctg gcagacggcc atgggcgttt ggcagcagtg cttggaggag     29760

tgcaacctca aggagctgca gaaactgcta aagcaaaact tgaaggacct atggacggcc     29820

ttcaacgagc gctccgtggc cgcgcacctg gcggacatca ttttccccga acgcctgctt     29880

aaaaccctgc aacagggtct gccagacttc accagtcaaa gcatgttgca gaactttagg     29940

aactttatcc tagagcgctc aggaatcttg cccgccacct gctgtgcact tcctagcgac     30000

tttgtgccca ttaagtaccg cgaatgccct ccgccgcttt ggggccactg ctaccttctg     30060

cagctagcca actaccttgc ctaccactct gacataatgg aagacgtgag cggtgacggt     30120

ctactggagt gtcactgtcg ctgcaaccta tgcaccccgc accgctccct ggtttgcaat     30180

tcgcagctgc ttaacgaaag tcaaattatc ggtacctttg agctgcaggg tccctcgcct     30240

gacgaaaagt ccgcggctcc ggggttgaaa ctcactccgg ggctgtggac gtcggcttac     30300

cttcgcaaat ttgtacctga ggactaccac gcccacgaga ttaggttcta cgaagaccaa     30360

tcccgcccgc caaatgcgga gcttaccgcc tgcgtcatta cccagggcca cattcttggc     30420

caattgcaag ccatcaacaa agcccgccaa gagtttctgc tacgaaaggg acggggggtt     30480

tacttggacc cccagtccgg cgaggagctc aacccaatcc ccccgccgcc gcagccctat     30540

cagcagcagc cgcgggccct tgcttcccag gatggcaccc aaaaagaagc tgcagctgcc     30600

gccgccaccc acggacgagg aggaatactg ggacagtcag gcagaggagg ttttggacga     30660

ggaggaggag gacatgatgg aagactggga gagcctagac gaggaagctt ccgaggtcga     30720

agaggtgtca gacgaaacac cgtcaccctc ggtcgcattc ccctcgccgg cgccccagaa     30780

atcggcaacc ggttccagca tggctacaac ctccgctcct caggcgccgc cggcactgcc     30840

cgttcgccga cccaaccgta gatgggacac cactggaacc agggccggta agtccaagca     30900

gccgccgccg ttagcccaag agcaacaaca gcgccaaggc taccgctcat ggcgcgggca     30960

caagaacgcc atagttgctt gcttgcaaga ctgtgggggc aacatctcct tcgcccgccg     31020

ctttcttctc taccatcacg gcgtggcctt cccccgtaac atcctgcatt actaccgtca     31080

tctctacagc ccatactgca ccggcggcag cggcagcggc agcaacagca gcggccacac     31140

agaagcaaag gcgaccggat agcaagactc tgacaaagcc caagaaatcc acagcggcgg     31200

cagcagcagg aggaggagcg ctgcgtctgg cgcccaacga acccgtatcg acccgcgagc     31260

ttagaaacag gatttttccc actctgtatg ctatatttca acagagcagg ggccaagaac     31320

aagagctgaa aataaaaaac aggtctctgc gatccctcac ccgcagctgc ctgtatcaca     31380

aaagcgaaga tcagcttcgg cgcacgctgg aagacgcgga ggctctcttc agtaaatact     31440

gcgcgctgac tcttaaggac tagtttcgcg ccctttctca aatttaagcg cgaaaactac     31500

gtcatctcca gcggccacac ccggcgccag cacctgtcgt cagcgccatt atgagcaagg     31560

aaattcccac gccctacatg tggagttacc agccacaaat gggacttgcg gctggagctg     31620

cccaagacta ctcaacccga ataaactaca tgagcgcggg accccacatg atatcccggg     31680

tcaacggaat ccgcgcccac cgaaaccgaa ttctcttgga acaggcggct attaccacca     31740

cacctcgtaa taaccttaat ccccgtagtt ggcccgctgc cctggtgtac caggaaagtc     31800

ccgctcccac cactgtggta cttcccagag acgcccaggc cgaagttcag atgactaact     31860

caggggcgca gcttgcgggc ggctttcgtc acagggtgcg gtcgcccggg cagggtataa     31920

ctcacctgac aatcagaggg cgaggtattc agctcaacga cgagtcggtg agctcctcgc     31980

ttggtctccg tccggacggg acatttcaga tcggcggcgc cggccgtcct tcattcacgc     32040

ctcgtcaggc aatcctaact ctgcagacct cgtcctctga gccgcgctct ggaggcattg     32100

gaactctgca atttattgag gagtttgtgc catcggtcta ctttaacccc ttctcgggac     32160

ctcccggcca ctatccggat caatttattc ctaactttga cgcggtaaag gactcggcgg     32220

acggctacga ctgaatgtta agtggagagg cagagcaact gcgcctgaaa cacctggtcc     32280

actgtcgccg ccacaagtgc tttgcccgcg actccggtga gttttgctac tttgaattgc     32340

ccgaggatca tatcgagggc ccggcgcacg gcgtccggct taccgcccag ggagagcttg     32400

cccgtagcct gattcgggag tttacccagc gccccctgct agttgagcgg gacaggggac     32460

cctgtgttct cactgtgatt tgcaactgtc ctaaccttgg attacatcaa gatcctctag     32520

ttataactag agtacccggg gatcttattc cctttaacta ataaaaaaaa ataataaagc     32580

atcacttact taaaatcagt tagcaaattt ctgtccagtt tattcagcag cacctccttg     32640

ccctcctccc agctctggta ttgcagcttc ctcctggctg caaactttct ccacaatcta     32700

aatggaatgt cagtttcctc ctgttcctgt ccatccgcac ccactatctt catgttgttg     32760

cagatgaagc gcgcaagacc gtctgaagat accttcaacc ccgtgtatcc atatgacacg     32820

gaaaccggtc ctccaactgt gccttttctt actcctccct ttgtatcccc caatgggttt     32880

caagagagtc cccctggggt actctctttg cgcctatccg aacctctagt tacctccaat     32940

ggcatgcttg cgctcaaaat gggcaacggc ctctctctgg acgaggccgg caaccttacc     33000

tcccaaaatg taaccactgt gagcccacct ctcaaaaaaa ccaagtcaaa cataaacctg     33060

gaaatatctg cacccctcac agttacctca gaagccctaa ctgtggctgc cgccgcacct     33120

ctaatggtcg cgggcaacac actcaccatg caatcacagg ccccgctaac cgtgcacgac     33180

tccaaactta gcattgccac ccaaggaccc ctcacagtgt cagaaggaaa gctagccctg     33240

caaacatcag gccccctcac caccaccgat agcagtaccc ttactatcac tgcctcaccc     33300

cctctaacta ctgccactgg tagcttgggc attgacttga aagagcccat ttatacacaa     33360

aatggaaaac taggactaaa gtacggggct cctttgcatg taacagacga cctaaacact     33420

ttgaccgtag caactggtcc aggtgtgact attaataata cttccttgca aactaaagtt     33480

actggagcct tgggttttga ttcacaaggc aatatgcaac ttaatgtagc aggaggacta     33540

aggattgatt ctcaaaacag acgccttata cttgatgtta gttatccgtt tgatgctcaa     33600

aaccaactaa atctaagact aggacagggc cctcttttta taaactcagc ccacaacttg     33660

gatattaact acaacaaagg cctttacttg tttacagctt caaacaattc caaaaagctt     33720

gaggttaacc taagcactgc caaggggttg atgtttgacg ctacagccat agccattaat     33780

gcaggagatg ggcttgaatt tggttcacct aatgcaccaa acacaaatcc cctcaaaaca     33840

aaaattggcc atggcctaga atttgattca aacaaggcta tggttcctaa actaggaact     33900

ggccttagtt ttgacagcac aggtgccatt acagtaggaa acaaaaataa tgataagcta     33960

actttgtgga ccacaccagc tccatctcct aactgtagac taaatgcaga gaaagatgct     34020

aaactcactt tggtcttaac aaaatgtggc agtcaaatac ttgctacagt ttcagttttg     34080

gctgttaaag gcagtttggc tccaatatct ggaacagttc aaagtgctca tcttattata     34140

agatttgacg aaaatggagt gctactaaac aattccttcc tggacccaga atattggaac     34200

tttagaaatg gagatcttac tgaaggcaca gcctatacaa acgctgttgg atttatgcct     34260

aacctatcag cttatccaaa atctcacggt aaaactgcca aaagtaacat tgtcagtcaa     34320

gtttacttaa acggagacaa aactaaacct gtaacactaa ccattacact aaacggtaca     34380

caggaaacag gagacacaac tccaagtgca tactctatgt cattttcatg ggactggtct     34440

ggccacaact acattaatga aatatttgcc acatcctctt acactttttc atacattgcc     34500

caagaataaa gaatcgtttg tgttatgttt caacgtgttt atttttcaat tgcagaaaat     34560

ttcaagtcat ttttcattca gtagtatagc cccaccacca catagcttat acagatcacc     34620

gtaccttaat caaactcaca gaaccctagt attcaacctg ccacctccct cccaacacac     34680

agagtacaca gtcctttctc cccggctggc cttaaaaagc atcatatcat gggtaacaga     34740

catattctta ggtgttatat tccacacggt ttcctgtcga gccaaacgct catcaagtga     34800

tattaataaa ctccccgggc agctcactta agttcatgtc gctgtccagc tgctgagcca     34860

caggctgctg tccaacttgc ggttgcttaa cgggcggcga aggagaagtc cacgcctaca     34920

tggggggaga gtcataatcg tgcatcagga tagggcggtg gtgctgcagc agcgcgcgaa     34980

taaactgctg ccgccgccgc tccgtcctgc aggaatacaa catggcagtg gtctcctcag     35040

cgatgattcg caccgcccgc agcataaggc gcttgtcctc cgggcacagc agcgcaccct     35100

gatctcactt aaatcagcac agtaactgca gcacagcacc acaatattgt tcaaaatccc     35160

acagtgcaag gcgctgtatc caaagctcat ggcggggacc acagaaccca cgtggccatc     35220

ataccacaag cgcaggtaga ttaagtggcg acccctcata aacacgctgg acataaacat     35280

tacctctttt ggcatgttgt aattcaccac ctcccggtac catataaacc tctgattaaa     35340

catggcgcca tccaccacca tcctaaacca gctggccaaa acctgccccg ccgggntata     35400

cactgcaggg aaccgggact tggacaatga caagtgggag agcccaggac tcgtaaccat     35460

ggatcatcat gctcgtcatg atatcaatgt tggcacaaca caggcacacg tgcatacact     35520

tcctcaggat tacaagctcc tcccgcgtta gaaccatatc ccagggaaca acccattcct     35580

gaatcagcgt aaatcccaca ctgcagggaa gacctcgcac gtaactcacg ttgtgcattg     35640

tcaaagtgtt acattcgggc agcagcggat gatcctccag tatggtagcg cgggtttctg     35700

tctcaaaagg aggtagacga tccctactgt acggagtgcg ccgagacaac cgagatcgtg     35760

ttggtcgtag tgtcatgcca aatggaacgc cggacgtagt catatttcct gaagcaaaac     35820

caggtgcggg cgtgacaaac agatctgcgt ctccggtctc gccgcttaga tcgctctgtg     35880

tagtagttgt agtatatcca ctctctcaaa gcatccaggc gccccctggc ttcgggttct     35940

atgtaaactc cttcatgcgc cgctgccctg ataacatcca ccaccgcaga ataagccaca     36000

cccagccaac ctacacattc gttctgcgag tcacacacgg gaggagcggg aagagctgga     36060

agaaccatgt tttttttttt attccaaaag attatccaaa acctcaaaat gaagatctat     36120

taagtgaacg cgctcccctc cggtggcgtg gtcaaactct acagccaaag aacagataat     36180

ggcatttgta agatgttgca caatggcttc caaaaggcaa acggccctca cgtccaagtg     36240

gacgtaaagg ctaaaccctt cagggtgaat ctcctctata aacattccag caccttcaac     36300

catgcccaaa taattctcat ctcgccacct tctcaatata tctctaagca aatcccgaat     36360

atttaagtcc gggccattgt aaaaaatttg gctccagagc gccctccacc ttcagcctca     36420

agcagcgaat catgattgca aaaattcagg ttcctcacag acctgtataa gattcaaaag     36480

cggaacatta acaaaaatac cgcgatcccg taggtccctt cgcagggcca gctgaacata     36540

atcgtgcagg tctgcacgga ccagcgcggc cacttccccg ccaggaacca tgacaaaaga     36600

acccacactg attatgacac gcatactcgg agctatgcta accagcgtag ccccgatgta     36660

agcttgttgc atgggcggcg atataaaatg caaggtgctg ctcaaaaaat caggcaaagc     36720

ctcgcgcaaa aaagaaagca catcgtagtc atgctcatgc agataaaggc aggtaagctc     36780

cggaaccacc acagaaaaag acaccatttt tctctcaaac atgtctgcgg gtttctgcat     36840

aaacacaaaa taaaataaca aaaaaacatt taaacattag aagcctgtct tacaacagga     36900

aaaacaaccc ttataagcat aagacggact acggccatgc cggcgtgacc gtaaaaaaac     36960

tggtcaccgt gattaaaaag caccaccgac agctcctcgg tcagtccgga gtcataatgt     37020

aagactcggt aaacacatca ggttgattca catcggtcag tgttaaaaag cgaccgaaat     37080

agccnggggg aatacaatac ccgcaggcgt agagacaaca ttacagcccc cataggaggt     37140

ataacaaaat taataggaga gaaaaacaca taaacacctg aaaaaccctc ctgcctaggc     37200

aaaatagcac cctcccgctc cagaacaaca tacagcgctt ccacagcggc agccataaca     37260

gtcagcctta ccagtaaaaa agaaaaccta ttaaaaaaac accactcgac acggcaccag     37320

ctcaatcagt cacagtgtaa aaaagggcca agtgcagagc gagtatatat aggactaaaa     37380

aatgacggta acggttaaag tccacaaaaa acacccagaa aaccgcacgc gaacctacgc     37440

ccagaaacga aagccaaaaa acccacaact tcctcaaatc gtcacttccg ttttcccacg     37500

ttacgtcact tcccatttta agaaaactac aattcccaac acatacaagt tactccgccc     37560

taaaacctac gtcacccgcc ccgttcccac gccccgcgcc acgtcacaaa ctccaccccc     37620

tcattatcat attggcttca atccaaaata aggtatatta ttgatgatg                 37669


<210> 11
<211> 6253
<212> DNA
<213> Artificial Sequence


<220> 
<223> Example starter rAAV vector

<220> 
<221> misc_feature
<222> 19..161
<223> /note="TR"

<220> 
<221> promoter
<222> 172..766
<223> /note="Pcmv"

<220> 
<221> misc_feature
<222> 763..942
<223> /note="SV40 SD, SA"

<220> 
<221> gene
<222> 988..1701
<223> /gene="GFP gene"

<220> 
<221> polyA_site
<222> 1712..1910
<223> /note="SV40 polyA"

<220> 
<221> enhancer
<222> 1922..2057
<223> /note="PYF441 enhancer"

<220> 
<221> misc_feature
<222> 2058..2186
<223> /note="HSV-tk"

<220> 
<221> gene
<222> 2198..3000
<223> /gene="neoR"

<220> 
<221> polyA_site
<222> 3010..3248
<223> /note="bGH poly A"

<220> 
<221> misc_feature
<222> 3259..3401
<223> /note="TR"

<220> 
<221> misc_feature
<222> 3850..4075
<223> /note="ColE1ori"

<220> 
<221> misc_feature
<222> 4325..5325
<223> /note="ApR"

<220> 
<221> misc_feature
<222> 5729..6188
<223> /note="f1+ origin"

<400> 11
gggggggggg ggggggggtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc       60

gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga      120

gcgcgcagag agggagtggc caactccatc actaggggtt cctagatctg aattcggtac      180

ccgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat      240

tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc      300

aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc      360

caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt      420

acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta      480

ccatggtgat gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg      540

gatttccaag tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac      600

gggactttcc aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg      660

tacggtggga ggtctatata agcagagctc gtttagtgaa ccgtcagatc gcctggagac      720

gccatccacg ctgttttgac ctccatagaa gacaccggga ccgatccagc ctccggactc      780

tagaggatcc ggtactcgag gaactgaaaa accagaaagt taactggtaa gtttagtctt      840

tttgtctttt atttcaggtc ccggatccgg tggtggtgca aatcaaagaa ctgctcctca      900

gtggatgttg cctttacttc taggcctgta cggaagtgtt acttctgctc taaaagctgc      960

ggaattgtac ccgcggccgc cgccaccatg agcaagggcg aggaactgtt cactggcgtg     1020

gtcccaattc tcgtggaact ggatggcgat gtgaatgggc acaaattttc tgtcagcgga     1080

gagggtgaag gtgatgccac atacggaaag ctcaccctga aattcatctg caccactgga     1140

aagctccctg tgccatggcc aacactggtc actaccctga cctatggcgt gcagtgcttt     1200

tccagatacc cagaccatat gaagcagcat gactttttca agagcgccat gcccgagggc     1260

tatgtgcagg agagaaccat ctttttcaaa gatgacggga actacaagac ccgcgctgaa     1320

gtcaagttcg aaggtgacac cctggtgaat agaatcgagc tgaagggcat tgactttaag     1380

gaggatggaa acattctcgg ccacaagctg gaatacaact ataactccca caatgtgtac     1440

atcatggccg acaagcaaaa gaatggcatc aaggtcaact tcaagatcag acacaacatt     1500

gaggatggat ccgtgcagct ggccgaccat tatcaacaga acactccaat cggcgacggc     1560

cctgtgctcc tcccagacaa ccattacctg tccacccagt ctgccctgtc taaagatccc     1620

aacgaaaaga gagaccacat ggtcctgctg gagtttgtga ccgctgctgg gatcacacat     1680

ggcatggacg agctgtacaa gtgagcggcc gcggggatcc agacatgata agatacattg     1740

atgagtttgg acaaaccaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt     1800

gtgatgctat tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca     1860

attgcattca ttttatgttt caggttcagg gggaggtgtg ggaggttttt tagtcgacct     1920

cgagcagtgt ggttttgcaa gaggaagcaa aaagcctctc cacccaggcc tggaatgttt     1980

ccacccaagt cgaaggcagt gtggttttgc aagaggaagc aaaaagcctc tccacccagg     2040

cctggaatgt ttccacccaa tgtcgagcaa ccccgcccag cgtcttgtca ttggcgaatt     2100

cgaacacgca gatgcagtcg gggcggcgcg gtcccaggtc cacttcgcat attaaggtga     2160

cgcgtgtggc ctcgaacacc gagcgaccct gcagccaata tgggatcggc cattgaacaa     2220

gatggattgc acgcaggttc tccggccgct tgggtggaga ggctattcgg ctatgactgg     2280

gcacaacaga caatcggctg ctctgatgcc gccgtgttcc ggctgtcagc gcaggggcgc     2340

ccggttcttt ttgtcaagac cgacctgtcc ggtgccctga atgaactgca ggacgaggca     2400

gcgcggctat cgtggctggc cacgacgggc gttccttgcg cagctgtgct cgacgttgtc     2460

actgaagcgg gaagggactg gctgctattg ggcgaagtgc cggggcagga tctcctgtca     2520

tctcaccttg ctcctgccga gaaagtatcc atcatggctg atgcaatgcg gcggctgcat     2580

acgcttgatc cggctacctg cccattcgac caccaagcga aacatcgcat cgagcgagca     2640

cgtactcgga tggaagccgg tcttgtcgat caggatgatc tggacgaaga gcatcagggg     2700

ctcgcgccag ccgaactgtt cgccaggctc aaggcgcgca tgcccgacgg cgaggatctc     2760

gtcgtgaccc atggcgatgc ctgcttgccg aatatcatgg tggaaaatgg ccgcttttct     2820

ggattcatcg actgtggccg gctgggtgtg gcggaccgct atcaggacat agcgttggct     2880

acccgtgata ttgctgaaga gcttggcggc gaatgggctg accgcttcct cgtgctttac     2940

ggtatcgccg ctcccgattc gcagcgcatc gccttctatc gccttcttga cgagttcttc     3000

tgaggggatc cgtcgactag agctcgctga tcagcctcga ctgtgccttc tagttgccag     3060

ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact     3120

gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt     3180

ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat     3240

gctggggaga gatctaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc     3300

gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt ggtcgcccgg     3360

cctcagtgag cgagcgagcg cgcagagagg gagtggccaa cccccccccc cccccccctg     3420

cagccctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct     3480

cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat     3540

cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga     3600

acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt     3660

ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt     3720

ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc     3780

gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa     3840

gcgtggcgct ttctcaatgc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct     3900

ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta     3960

actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg     4020

gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc     4080

ctaactacgg ctacactaga aggacagtat ttggtatctg cgctctgctg aagccagtta     4140

ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg     4200

gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt     4260

tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg     4320

tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta     4380

aatcaatcta aagtatatat gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg     4440

aggcacctat ctcagcgatc tgtctatttc gttcatccat agttgcctga ctccccgtcg     4500

tgtagataac tacgatacgg gagggcttac catctggccc cagtgctgca atgataccgc     4560

gagacccacg ctcaccggct ccagatttat cagcaataaa ccagccagcc ggaagggccg     4620

agcgcagaag tggtcctgca actttatccg cctccatcca gtctattaat tgttgccggg     4680

aagctagagt aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc attgctacag     4740

gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt cagctccggt tcccaacgat     4800

caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc     4860

cgatcgttgt cagaagtaag ttggccgcag tgttatcact catggttatg gcagcactgc     4920

ataattctct tactgtcatg ccatccgtaa gatgcttttc tgtgactggt gagtactcaa     4980

ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac     5040

gggataatac cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt     5100

cggggcgaaa actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc     5160

gtgcacccaa ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa     5220

caggaaggca aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca     5280

tactcttcct ttttcaatat tattgaagca tttatcaggg ttattgtctc atgagcggat     5340

acatatttga atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa     5400

aagtgccacc tgacgtctaa gaaaccatta ttatcatgac attaacctat aaaaataggc     5460

gtatcacgag gccctttcgt ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca     5520

tgcagctccc ggagacggtc acagcttgtc tgtaagcgga tgccgggagc agacaagccc     5580

gtcagggcgc gtcagcgggt gttggcgggt gtcggggctg gcttaactat gcggcatcag     5640

agcagattgt actgagagtg caccatatgc ggtgtgaaat accgcacaga tgcgtaagga     5700

gaaaataccg catcaggaaa ttgtaaacgt taatattttg ttaaaattcg cgttaaattt     5760

ttgttaaatc agctcatttt ttaaccaata ggccgaaatc ggcaaaatcc cttataaatc     5820

aaaagaatag accgagatag ggttgagtgt tgttccagtt tggaacaaga gtccactatt     5880

aaagaacgtg gactccaacg tcaaagggcg aaaaaccgtc tatcagggcg atggcccact     5940

acgtgaacca tcaccctaat caagtttttt ggggtcgagg tgccgtaaag cactaaatcg     6000

gaaccctaaa gggagccccc gatttagagc ttgacgggga aagccggcga acgtggcgag     6060

aaaggaaggg aagaaagcga aaggagcggg cgctagggcg ctggcaagtg tagcggtcac     6120

gctgcgcgta accaccacac ccgccgcgct taatgcgccg ctacagggcg cgtcgcgcca     6180

ttcgccattc aggctacgca actgttggga agggcgatcg gtgcgggcct cttcgctatt     6240

acgccaggct gca                                                        6253


<210> 12
<211> 280
<212> DNA
<213> Adeno-associated virus - 2


<220> 
<223> Minimal RIS-Ad

<400> 12
aaagggtgga gccaagaaaa gacccgcccc cagtgacgca gatataagtg agcccaaacg     60

ggtgcgcgag tcagttgcgc agccatcgac gtcagacgcg gaagcttcga tcaactacgc    120

agacaggtac caaaacaaat gttctcgtca cgtgggcatg aatctgatgc tgtttccctg    180

cagacaatgc gagagaatga atcagaattc aaatatctgc ttcactcacg gacagaaaga    240

ctgtttagag tgctttcccg tgtcagaatc tcaacccgtt                          280


<210> 13
<211> 280
<212> DNA
<213> Artificial Sequence


<220> 
<223> Recoded minimal RIS-Ad

<400> 13
gaaggggggg gccaaaaagc gccctgcacc ttccgacgcc gacatttccg agccaaagag     60

agtgcgtgag agtgtggccc aaccctccac cagtgatgcc gaggcctcca ttaattatgc    120

cgaccgctat cagaataagt gctcaaggca tgtcgggatg aacctgatgc tgttcccatg    180

ccgccagtgc gagcgcatga accagaacag caacatttgt tttacccacg ggcagaagga    240

ttgcctggaa tgcttcccgg tcagcgagtc acagccggtg                          280


<210> 14
<211> 735
<212> PRT
<213> Adeno-associated virus - 2


<220> 
<223> AAV-2 VP1 amino acid sequence

<400> 14
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  
Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             
Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 
Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     
Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         
Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             
Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 
Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 
Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     
Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         
Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             
Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 
Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 
Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     
Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             
Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 
Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 
Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     
Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         
Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             
Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 
Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 
Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     
Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         
Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             
Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 
Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 
His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     
Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         
Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             
Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 
Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 
Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 

<210> 15
<211> 155
<212> DNA
<213> Artificial Sequence


<220> 
<223> HSV-106, HSV-TK promoter nucleotides -106 to +49

<400> 15
aaccccgccc agcgtcttgt cattggcgaa ttcgaacacg cagatgcagt cggggcggcg     60

cggtcccagg tccacttcgc atattaaggt gacgcgtgtg gcctcgaaca ccgagcgacc    120

ctgcagcgac ccgcttaaca gcgtcaacag cgtgc                               155


<210> 16
<211> 126
<212> DNA
<213> Artificial Sequence


<220> 
<223> HSV-M1, HSV-TK promoter with proximal Sp1 site deleted and distal
      Sp1 site and CCAAT box in normal orientation

<400> 16
aaccccgccc agcgtcttgt cattggcgaa ttggtcccag gtccacttcg catattaagg     60

tgacgcgtgt ggcctcgaac accgagcgac cctgcagcga cccgcttaac agcgtcaaca    120

gcgtgc                                                               126


<210> 17
<211> 126
<212> DNA
<213> Artificial Sequence


<220> 
<223> HSV-M3, HSV-TK promoter with proximal Sp1 site deleted and distal
      Sp1 site and CCAAT box in reverse orientation

<400> 17
aattcgccaa tgacaagacg ctgggcgggg ttggtcccag gtccacttcg catattaagg     60

tgacgcgtgt ggcctcgaac accgagcgac cctgcagcga cccgcttaac agcgtcaaca    120

gcgtgc                                                               126


<210> 18
<211> 110
<212> DNA
<213> Artificial Sequence


<220> 
<223> HSV-M2, HSV-TK promoter with proximal Sp1 site and CCAAT box
      deleted and distal Sp1 site in normal orientation

<400> 18
aaccccgccc agcgtcggtc ccaggtccac ttcgcatatt aaggtgacgc gtgtggcctc     60

gaacaccgag cgaccctgca gcgacccgct taacagcgtc aacagcgtgc               110


<210> 19
<211> 110
<212> DNA
<213> Artificial Sequence


<220> 
<223> HSV-M4, HSV-TK promoter with proximal Sp1 site and CCAAT box
      deleted and distal Sp1 site in reverse orientation

<400> 19
gacgctgggc ggggttggtc ccaggtccac ttcgcatatt aaggtgacgc gtgtggcctc     60

gaacaccgag cgaccctgca gcgacccgct taacagcgtc aacagcgtgc               110


<210> 20
<211> 108
<212> DNA
<213> Artificial Sequence


<220> 
<223> HSV-59, HSV-TK promoter nucleotides -59 to +49

<400> 20
agtcggggcg gcgcggtccc aggtccactt cgcatattaa ggtgacgcgt gtggcctcga     60

acaccgagcg accctgcagc gacccgctta acagcgtcaa cagcgtgc                 108


<210> 21
<211> 306
<212> DNA
<213> Simian virus 40


<220> 
<223> SV40 promoter nucleotides -256 to +46

<400> 21
ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg catctcaatt     60

agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca    120

tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc ccgcccctaa    180

ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag    240

aggccgaggc cgcctcggcc tctgagctat tccagaagta gtgaggaggc ttttttggag    300

gcctag                                                               306


<210> 22
<211> 10
<212> DNA
<213> Artificial Sequence


<220> 
<223> preferred Sp1 binding site (consensus binding sequence)

<400> 22
kgggcggrry                                                           10


