                         SEQUENCE LISTING

<110>  Rigshospitalet
       University of Copenhagen
 
<120>  Antibody-drug conjugates comprising humanized antibodies 
       targeting uPARAP

<130>  P5888PC00

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete light chain sequence (LC4) of humanised LC4HC3


<220>
<221>  MISC_FEATURE
<222>  (1)..(214)

<400>  1

Glu Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Asn Val Asp Thr Tyr 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Gln Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Ile Tyr Tyr Cys Gln Gln Tyr His Asn Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  2
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete light chain sequence (LC4) of humanised LC4HC3 in 
       combination with signal peptide used in CHO cells expression 
       system; Signal peptide underlined


<220>
<221>  MISC_FEATURE
<222>  (1)..(234)

<400>  2

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Glu Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Asn 
        35                  40                  45              


Val Asp Thr Tyr Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
    50                  55                  60                  


Gln Pro Leu Ile Tyr Ser Ala Ser Ser Arg Phe Ser Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Ala Glu Asp Val Ala Ile Tyr Tyr Cys Gln Gln Tyr His 
            100                 105                 110         


Asn Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  3
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain (LC4) variable region of humanised LC4HC3


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)

<400>  3

Glu Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Asn Val Asp Thr Tyr 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Gln Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Ile Tyr Tyr Cys Gln Gln Tyr His Asn Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  4
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete heavy chain sequence (HC3) of humanised LC4HC3


<220>
<221>  MISC_FEATURE
<222>  (1)..(449)

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Thr Lys Ser Gly Val Ser Thr Tyr Ala Ala Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Tyr Ser Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Pro Tyr Tyr Ser Gln Tyr Gly Ser Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  5
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete heavy chain sequence (HC3) of humanised LC4HC3 in 
       combination with signal peptide used in CHO cell expression 
       system; Signal peptide underlined


<220>
<221>  MISC_FEATURE
<222>  (1)..(468)

<400>  5

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe 
        35                  40                  45              


Ile Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Met Gly Ser Ile Asn Thr Lys Ser Gly Val Ser Thr Tyr Ala 
65                  70                  75                  80  


Ala Glu Phe Lys Gly Arg Val Thr Ile Tyr Ser Asp Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Pro Pro Tyr Tyr Ser Gln Tyr Gly Ser Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  6
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain (HC3) variable region of humanised LC4HC3


<220>
<221>  MISC_FEATURE
<222>  (1)..(119)

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Thr Lys Ser Gly Val Ser Thr Tyr Ala Ala Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Tyr Ser Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Pro Tyr Tyr Ser Gln Tyr Gly Ser Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  7
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete light chain sequence (LC0) of chimeric LC0HC0


<220>
<221>  MISC_FEATURE
<222>  (1)..(214)

<400>  7

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Tyr 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Arg Phe Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Thr Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr His Asn Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain (LC0) variable region of chimeric LC0HC0


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)

<400>  8

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Tyr 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Arg Phe Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Thr Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr His Asn Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  9
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete heavy chain sequence (HC0) of chimeric LC0HC0


<220>
<221>  MISC_FEATURE
<222>  (1)..(449)

<400>  9

Gln Val His Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Thr Lys Ser Gly Val Ser Thr Tyr Ala Ala Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Pro Tyr Tyr Ser Gln Tyr Gly Ser Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  10
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain (HC0) variable region of chimeric LC0HC0


<220>
<221>  MISC_FEATURE
<222>  (1)..(119)

<400>  10

Gln Val His Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Thr Lys Ser Gly Val Ser Thr Tyr Ala Ala Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Pro Tyr Tyr Ser Gln Tyr Gly Ser Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  11
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding LC4 incl. signal peptide


<220>
<221>  misc_feature
<222>  (1)..(705)

<400>  11
atggtcagct ctgctcaatt tctcggactc cttcttctgt gctttcaagg aacacgctgc       60

gagatcgtga tgactcagtc cccggactca ctggcagtgt ccttgggcga aagagccacc      120

atcaactgta aagccagcca gaacgtggac acctacgtgg tctggtacca gcagaagcct      180

ggacagccac cgcagccgtt gatctactcg gcctcatcaa ggttctccgg ggtgccggac      240

cgcttctccg gatccggctc cggcaccgat ttcaccctga ccatctcctc actgcaagcc      300

gaggacgtgg ctatctacta ttgccagcag taccacaact ccccactgac cttcggtggc      360

ggaactaagg tcgagattaa gcggaccgtg gcggccccct ctgtgttcat tttccctccc      420

tcggacgaac agctgaagtc gggaacagcc tccgtcgtgt gcctgctcaa caacttctac      480

ccccgggaag cgaaggtcca gtggaaagtg gataacgcac tccaatcggg gaactcccag      540

gaatccgtga ctgagcagga ctcgaaggat tccacttact ccctgtcgtc caccctgact      600

ctgagcaagg ccgactacga gaagcataag gtctacgcct gcgaagtgac ccaccagggt      660

ctgagctccc ctgtgaccaa gagctttaat cggggcgaat gttga                      705


<210>  12
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding HC3 incl. signal peptide


<220>
<221>  misc_feature
<222>  (1)..(1407)

<400>  12
atgggttgga ccctcgtctt tctgttcctt ctttccgtca ccgctggagt gcatagccag       60

gtccaattgg tgcagtcagg cgccgaagtg aaaaagcctg gggcgtcggt gaaagtgtcc      120

tgcaaagcct cgggctacat ctttattgac tacggaatgc actgggtccg ccaggccccg      180

ggccagaggc tggagtggat gggatccatt aacaccaaga gcggagtgtc aacttacgca      240

gccgagttca agggacgggt gaccatctat agcgatacct ctgcgtcgac cgcctacatg      300

gaattgtcat cactccggtc cgaggacact gccgtgtact tctgcgcaag gccaccctac      360

tactcgcaat acggcagcta ctggggccag ggaacacttg tgaccgtgtc gagcgcgtcc      420

accaagggtc cctccgtgtt ccctctcgcg ccgtcctcaa agtctacctc cggtggaact      480

gccgcgctcg gttgtctcgt gaaggactac ttcccggagc ctgtgactgt ctcctggaac      540

tccggggccc tcaccagcgg agtgcacact ttccccgccg tgctgcaatc ctccggcctg      600

tacagcctgt cctccgtcgt gactgtgcct agctcctccc tgggaaccca gacctacatc      660

tgcaacgtga accacaagcc ctccaacacc aaggtcgaca agaaggtcga accgaagtcg      720

tgcgacaaga ctcatacgtg ccctccttgc ccggccccgg aactgctggg aggcccatcc      780

gtgttcctgt tcccacccaa gcctaaggat accctgatga tcagcagaac accggaagtg      840

acctgtgtgg tggtggacgt cagccacgaa gatcccgagg tcaagttcaa ttggtacgtg      900

gacggggtgg aggtgcacaa cgcaaagacc aagccccggg aggaacagta caactccacc      960

tatcgcgtgg tgtcggtgct gacggtgctg caccaggact ggttgaacgg aaaggagtat     1020

aagtgcaaag tgtcgaacaa ggccctgccc gctcctatcg aaaagaccat ctccaaggcc     1080

aagggccagc cgcgggaacc ccaggtctac actctcccac cgagccgcga cgaactgact     1140

aagaatcaag tgtcgctgac ttgcctcgtc aagggcttct acccgtccga catcgccgtg     1200

gaatgggaga gcaacggcca gccggaaaac aactacaaga ccacccctcc cgtgctggat     1260

tccgacgggt ccttcttcct gtactcaaaa ctgaccgtgg ataagtccag atggcagcag     1320

ggcaatgtct tttcatgctc cgtgatgcac gaggctctgc ataaccacta cacccagaag     1380

tcgctgtccc tgtccccggg gaagtga                                         1407


<210>  13
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete light chain sequence (LC3) of humanised LC3HC3


<220>
<221>  MISC_FEATURE
<222>  (1)..(234)

<400>  13

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Val Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Val Thr Ile Asn Cys Lys Ala Ser Gln Asn 
        35                  40                  45              


Val Asp Thr Tyr Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Ser Arg Phe Ser Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr His 
            100                 105                 110         


Asn Ser Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


