                         SEQUENCE LISTING

<110>  GlaxoSmithKline Biologicals S.A.
 
<120>  Influenza antigens

<130>  VB67134WO01

<150>  EP21182184.8
<151>  2021-06-28

<150>  GB2116787.9
<151>  2021-11-22

<160>  179   

<170>  PatentIn version 3.5

<210>  1
<211>  582
<212>  PRT
<213>  Influenza B virus

<400>  1

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
    530                 535                 540                 


Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr 
545                 550                 555                 560 


Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg Asp Asn Val 
                565                 570                 575     


Ser Cys Ser Ile Cys Leu 
            580         


<210>  2
<211>  320
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem - TEV cleavage site -
       foldon - poly His

<400>  2

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Gly Ser Gly Glu Ala Asp Cys 
    50                  55                  60                  


Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro Tyr Tyr Thr 
65                  70                  75                  80  


Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp Val Lys Thr 
                85                  90                  95      


Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys Leu 
            100                 105                 110         


Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly 
        115                 120                 125             


Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly 
    130                 135                 140                 


Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala 
145                 150                 155                 160 


Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu Val 
                165                 170                 175     


Lys Asn Gly Ser Gly Ser Asp Leu Arg Ala Asp Thr Ile Ser Ser Gln 
            180                 185                 190         


Ile Glu Leu Ala Val Leu Leu Ser Asn Glu Gly Ile Ile Asn Ser Glu 
        195                 200                 205             


Asp Glu His Leu Leu Ala Leu Glu Arg Lys Leu Lys Lys Met Leu Gly 
    210                 215                 220                 


Pro Ser Ala Val Glu Ile Gly Asn Gly Cys Phe Glu Thr Lys His Lys 
225                 230                 235                 240 


Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asp Ala 
                245                 250                 255     


Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala 
            260                 265                 270         


Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln Gly Gly Ser Lys Gly Tyr 
        275                 280                 285             


Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly 
    290                 295                 300                 


Glu Trp Val Leu Leu Ser Thr Phe Leu Gly His His His His His His 
305                 310                 315                 320 


<210>  3
<211>  273
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem - TEV cleavage site -
       foldon - poly His

<400>  3

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys Leu 
    50                  55                  60                  


Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly 
65                  70                  75                  80  


Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly 
                85                  90                  95      


Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala 
            100                 105                 110         


Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu Val 
        115                 120                 125             


Lys Asn Gly Pro Ser Pro Gly Asp Leu Arg Ala Asp Thr Ile Ser Ser 
    130                 135                 140                 


Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu Gly Ile Ile Asn Ser 
145                 150                 155                 160 


Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys Leu Lys Lys Met Leu 
                165                 170                 175     


Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys Phe Glu Thr Lys His 
            180                 185                 190         


Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asp 
        195                 200                 205             


Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala 
    210                 215                 220                 


Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln Gly Gly Ser Lys Gly 
225                 230                 235                 240 


Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp 
                245                 250                 255     


Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly His His His His His 
            260                 265                 270         


His 
    


<210>  4
<211>  262
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem - TEV cleavage site -
       foldon - poly His

<400>  4

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys Leu 
    50                  55                  60                  


Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly 
65                  70                  75                  80  


Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly 
                85                  90                  95      


Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala 
            100                 105                 110         


Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu Gly 
        115                 120                 125             


Ser Gly Ser Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    130                 135                 140                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
145                 150                 155                 160 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                165                 170                 175     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            180                 185                 190         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        195                 200                 205             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    210                 215                 220                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
225                 230                 235                 240 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                245                 250                 255     


His His His His His His 
            260         


<210>  5
<211>  263
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem - TEV cleavage site -
       foldon - poly His

<400>  5

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys Leu 
    50                  55                  60                  


Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly 
65                  70                  75                  80  


Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly 
                85                  90                  95      


Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala 
            100                 105                 110         


Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu Gly 
        115                 120                 125             


Ser Gly Ser Gly Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn 
    130                 135                 140                 


Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg 
145                 150                 155                 160 


Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly 
                165                 170                 175     


Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile 
            180                 185                 190         


Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp 
        195                 200                 205             


Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe 
    210                 215                 220                 


Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln 
225                 230                 235                 240 


Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
                245                 250                 255     


Gly His His His His His His 
            260             


<210>  6
<211>  262
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions - TEV cleavage site - foldon - poly His

<400>  6

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys Leu 
    50                  55                  60                  


Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly 
65                  70                  75                  80  


Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly 
                85                  90                  95      


Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala 
            100                 105                 110         


Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Glu Leu Glu Gly 
        115                 120                 125             


Ser Gly Ser Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Val Asn Glu 
    130                 135                 140                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
145                 150                 155                 160 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                165                 170                 175     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            180                 185                 190         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        195                 200                 205             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    210                 215                 220                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
225                 230                 235                 240 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                245                 250                 255     


His His His His His His 
            260         


<210>  7
<211>  264
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions - TEV cleavage site - foldon - poly His

<400>  7

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys Leu 
    50                  55                  60                  


Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly 
65                  70                  75                  80  


Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly 
                85                  90                  95      


Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala 
            100                 105                 110         


Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Glu Leu Glu Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Val 
    130                 135                 140                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
145                 150                 155                 160 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn 
                165                 170                 175     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            180                 185                 190         


Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        195                 200                 205             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr 
    210                 215                 220                 


Phe Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly 
225                 230                 235                 240 


Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe 
                245                 250                 255     


Leu Gly His His His His His His 
            260                 


<210>  8
<211>  265
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions - TEV cleavage site - foldon - poly His

<400>  8

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Gly Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys 
    50                  55                  60                  


Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu 
65                  70                  75                  80  


Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His 
                85                  90                  95      


Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu 
            100                 105                 110         


Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Glu Leu Glu 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    130                 135                 140                 


Val Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
145                 150                 155                 160 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                165                 170                 175     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            180                 185                 190         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        195                 200                 205             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu 
    210                 215                 220                 


Tyr Phe Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
225                 230                 235                 240 


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
                245                 250                 255     


Phe Leu Gly His His His His His His 
            260                 265 


<210>  9
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions - TEV cleavage site - foldon - poly His

<400>  9

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Pro Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  10
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions - TEV cleavage site - foldon - poly His

<400>  10

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Pro 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  11
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions - TEV cleavage site - foldon - poly His

<400>  11

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Pro Asp Glu Pro 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  12
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions - TEV cleavage site - foldon - poly His

<400>  12

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  13
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions - TEV cleavage site - foldon - poly His

<400>  13

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Val Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  14
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions - TEV cleavage site - foldon - poly His

<400>  14

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Met Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  15
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions - TEV cleavage site - foldon - poly His

<400>  15

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Val Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  16
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions - TEV cleavage site - foldon - poly His

<400>  16

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Leu Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  17
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions - TEV cleavage site - foldon - poly His

<400>  17

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  18
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions - TEV cleavage site - foldon - poly His

<400>  18

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Ile His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  19
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions - TEV cleavage site - foldon - poly His

<400>  19

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Ile Ile Ile Asn Ser Glu Asp Leu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  20
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions - TEV cleavage site - foldon - poly His

<400>  20

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  21
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions - TEV cleavage site - foldon - poly His

<400>  21

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Val Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Leu Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  22
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions - TEV cleavage site - foldon - poly His

<400>  22

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Met Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  23
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions - TEV cleavage site - foldon - poly His

<400>  23

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Met Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Val Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  24
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions - TEV cleavage site - foldon - poly His

<400>  24

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Val Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Val His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  25
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions - TEV cleavage site - foldon - poly His

<400>  25

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Met Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Val Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Val His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  26
<211>  27
<212>  PRT
<213>  Bacteriophage T4

<400>  26

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  27
<211>  15
<212>  PRT
<213>  Influenza B virus

<400>  27

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala 
1               5                   10                  15  


<210>  28
<211>  23
<212>  PRT
<213>  Influenza B virus

<400>  28

Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr Leu 
1               5                   10                  15      


Met Ile Ala Ile Phe Val Val 
            20              


<210>  29
<211>  966
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem - 
       TEV cleavage site - foldon - poly His

<400>  29
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc cggcagcggc      180

gaggccgact gcctgcacga gaagtacggc ggcctgaaca agagcaagcc ctactacacc      240

ggcgagcacg ccaaggccat cggcaactgc cccatctggg tgaagacccc cctgaagctg      300

gccaacggca ccaagtacag accccccgcc aagctgctga aggagagagg gttcttcggc      360

gccatcgccg gcttcctgga gggcggctgg gaaggcatga tcgctgggtg gcacggctac      420

acaagccacg gcgctcatgg cgtggccgtc gccgccgacc tcaagagcac ccaagaggcc      480

atcaacaaga tcaccaagaa cctgaacagc ctgagcgagc tggaggtgaa gaacggcagc      540

ggcagcgacc tgagagccga caccatcagc agccaaatcg agctggccgt gctgctgagc      600

aacgagggca tcatcaacag cgaggacgag cacctgctgg ccctggagag aaagctgaag      660

aagatgctgg gccctagcgc cgtggagatc gggaacggct gcttcgagac caagcacaag      720

tgcaatcaga cctgcctgga cagaatcgcc gccggcacct tcgacgccgg cgagttcagc      780

ctgcccacct tcgacagcct gaacatcacc gccgctagcc tgggcagcga gaacctgtac      840

ttccaaggcg gcagcaaggg ctacatcccc gaggccccta gagacggcca agcctacgtg      900

agaaaggacg gcgagtgggt gctgctgagc accttcctgg gccaccatca ccatcaccac      960

tgatga                                                                 966


<210>  30
<211>  825
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem - 
       TEV cleavage site - foldon - poly His

<400>  30
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gggcagcctg aagctggcca acggcaccaa gtacagaccc      180

cccgccaagc tgctgaagga gagagggttc ttcggcgcca tcgccggctt cctggagggc      240

ggctgggaag gcatgatcgc tgggtggcac ggctacacaa gccacggcgc tcatggcgtg      300

gccgtcgccg ccgacctcaa gagcacccaa gaggccatca acaagatcac caagaacctg      360

aacagcctga gcgagctgga ggtgaagaac ggccctagcc ccggcgacct gagagccgac      420

accatcagca gccaaatcga gctggccgtg ctgctgagca acgagggcat catcaacagc      480

gaggacgagc acctgctggc cctggagaga aagctgaaga agatgctggg ccctagcgcc      540

gtggagatcg ggaacggctg cttcgagacc aagcacaagt gcaatcagac ctgcctggac      600

agaatcgccg ccggcacctt cgacgccggc gagttcagcc tgcccacctt cgacagcctg      660

aacatcaccg ccgctagcct gggcagcgag aacctgtact tccaaggcgg cagcaagggc      720

tacatccccg aggcccctag agacggccaa gcctacgtga gaaaggacgg cgagtgggtg      780

ctgctgagca ccttcctggg ccaccatcac catcaccact gatga                      825


<210>  31
<211>  792
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem - 
       TEV cleavage site - foldon - poly His

<400>  31
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gggcagcctg aagctggcca acggcaccaa gtacagaccc      180

cccgccaagc tgctgaagga gagagggttc ttcggcgcca tcgccggctt cctggagggc      240

ggctgggaag gcatgatcgc tgggtggcac ggctacacaa gccacggcgc tcatggcgtg      300

gccgtcgccg ccgacctcaa gagcacccaa gaggccatca acaagatcac caagaacctg      360

aacagcctga gcgagctgga gggcagcggc agcagcagcc aaatcgagct ggccgtgctg      420

ctgagcaacg agggcatcat caacagcgag gacgagcacc tgctggccct ggagagaaag      480

ctgaagaaga tgctgggccc tagcgccgtg gagatcggga acggctgctt cgagaccaag      540

cacaagtgca atcagacctg cctggacaga atcgccgccg gcaccttcga cgccggcgag      600

ttcagcctgc ccaccttcga cagcctgaac atcaccgccg ctagcctggg cagcgagaac      660

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc      720

tacgtgagaa aggacggcga gtgggtgctg ctgagcacct tcctgggcca ccatcaccat      780

caccactgat ga                                                          792


<210>  32
<211>  795
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem - 
       TEV cleavage site - foldon - poly His

<400>  32
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gggcagcctg aagctggcca acggcaccaa gtacagaccc      180

cccgccaagc tgctgaagga gagagggttc ttcggcgcca tcgccggctt cctggagggc      240

ggctgggaag gcatgatcgc tgggtggcac ggctacacaa gccacggcgc tcatggcgtg      300

gccgtcgccg ccgacctcaa gagcacccaa gaggccatca acaagatcac caagaacctg      360

aacagcctga gcgagctgga gggcagcggc agcggcagca gccaaatcga gctggccgtg      420

ctgctgagca acgagggcat catcaacagc gaggacgagc acctgctggc cctggagaga      480

aagctgaaga agatgctggg ccctagcgcc gtggagatcg ggaacggctg cttcgagacc      540

aagcacaagt gcaatcagac ctgcctggac agaatcgccg ccggcacctt cgacgccggc      600

gagttcagcc tgcccacctt cgacagcctg aacatcaccg ccgctagcct gggcagcgag      660

aacctgtact tccaaggcgg cagcaagggc tacatccccg aggcccctag agacggccaa      720

gcctacgtga gaaaggacgg cgagtgggtg ctgctgagca ccttcctggg ccaccatcac      780

catcaccact gatga                                                       795


<210>  33
<211>  792
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions - TEV cleavage site - foldon - poly
       His.

<400>  33
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gggcagcctg aagctggcca acggcaccaa gtacagaccc      180

cccgccaagc tgctgaagga gagagggttc ttcggcgcca tcgccggctt cctggagggc      240

ggctgggaag gcatgatcgc tgggtggcac ggctacacaa gccacggcgc tcatggcgtg      300

gccgtcgccg ccgacctcaa gagcacccaa gaggccatca acaagatcac caagatgctg      360

aacagcctga gcgagctgga gggcagcggc agcagcagcc aaatcgagct ggccgtgctg      420

ctggtgaacg agggcatcat caacagcgag gacgagcacc tgctggccct ggagagaaag      480

ctgaagaaga tgctgggccc tagcgccgtg gagatcggga acggctgctt cgagaccaag      540

cacaagtgca atcagacctg cctggacaga atcgccgccg gcaccttcga cgccggcgag      600

ttcagcctgc ccaccttcga cagcctgaac atcaccgccg ctagcctggg cagcgagaac      660

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc      720

tacgtgagaa aggacggcga gtgggtgctg ctgagcacct tcctgggcca ccatcaccat      780

caccactgat ga                                                          792


<210>  34
<211>  798
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions - TEV cleavage site - foldon - poly
       His.

<400>  34
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gggcagcctg aagctggcca acggcaccaa gtacagaccc      180

cccgccaagc tgctgaagga gagagggttc ttcggcgcca tcgccggctt cctggagggc      240

ggctgggaag gcatgatcgc tgggtggcac ggctacacaa gccacggcgc tcatggcgtg      300

gccgtcgccg ccgacctcaa gagcacccaa gaggccatca acaagatcac caagatgctg      360

aacagcctga gcgagctgga gggcagcggc ggcagcggca gcagccaaat cgagctggcc      420

gtgctgctgg tgaacgaggg catcatcaac agcgaggacg agcacctgct ggccctggag      480

agaaagctga agaagatgct gggccctagc gccgtggaga tcgggaacgg ctgcttcgag      540

accaagcaca agtgcaatca gacctgcctg gacagaatcg ccgccggcac cttcgacgcc      600

ggcgagttca gcctgcccac cttcgacagc ctgaacatca ccgccgctag cctgggcagc      660

gagaacctgt acttccaagg cggcagcaag ggctacatcc ccgaggcccc tagagacggc      720

caagcctacg tgagaaagga cggcgagtgg gtgctgctga gcaccttcct gggccaccat      780

caccatcacc actgatga                                                    798


<210>  35
<211>  801
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions - TEV cleavage site - foldon - poly
       His.

<400>  35
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gggcagcggc ctgaagctgg ccaacggcac caagtacaga      180

ccccccgcca agctgctgaa ggagagaggg ttcttcggcg ccatcgccgg cttcctggag      240

ggcggctggg aaggcatgat cgctgggtgg cacggctaca caagccacgg cgctcatggc      300

gtggccgtcg ccgccgacct caagagcacc caagaggcca tcaacaagat caccaagatg      360

ctgaacagcc tgagcgagct ggagggcagc ggcggcagcg gcagcagcca aatcgagctg      420

gccgtgctgc tggtgaacga gggcatcatc aacagcgagg acgagcacct gctggccctg      480

gagagaaagc tgaagaagat gctgggccct agcgccgtgg agatcgggaa cggctgcttc      540

gagaccaagc acaagtgcaa tcagacctgc ctggacagaa tcgccgccgg caccttcgac      600

gccggcgagt tcagcctgcc caccttcgac agcctgaaca tcaccgccgc tagcctgggc      660

agcgagaacc tgtacttcca aggcggcagc aagggctaca tccccgaggc ccctagagac      720

ggccaagcct acgtgagaaa ggacggcgag tgggtgctgc tgagcacctt cctgggccac      780

catcaccatc accactgatg a                                                801


<210>  36
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions - TEV cleavage site - 
       foldon - poly His

<400>  36
atgaaggcca ttatcgtgct cctgatggtg gtgacaagca atgctgacag aatttgcacc       60

gggatcacaa gcagcaacag ccctcacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagaggcaa gctgtgcccc aaatgtctga attgtaccga tctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacatc cggctgcttt cccattatgc acgaccggac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca taacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcgggag ctgccccaac      480

attaccaacg gcaacggctt ctttgccacc atggcctggg ctgtgcccaa gaacaaaacc      540

gctaccaacc ccctgaccat cgaggtgccc tatatttgca ccgaaggcga ggatcagatc      600

acagtctggg gctttcacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacaa cacactacgt gtcccaaatc      720

ggcggcttcc ccaatcagac cgaagatggg ggcctgcctc agagcggccg gatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaaag tgatcaaggg gtccctcccc      900

ctgatcggcg aggctgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcatgc caaggccatc ggcaactgcc ccatttgggt caagaccccc     1020

ctgaagctcg ccaacggcac caaatacaga cctcccgcca agctcctgaa ggagagaggc     1080

tttttcggcg ccatcgccgg cttcctggag gggggctggg aaggcatgat cgccggctgg     1140

cacggctaca catcccacgg cgcccacggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaaaat caccaagaac ctcaacagcc tgtccgagct ggaagtcaag     1260

aacctgcagc ggctgagcgg cgcccctgac gaactgcaca acgagatcct cgagctggac     1320

gagaaggtgg acgacctgag agctgacacc atcagcagcc aaattgagct ggctgtgctg     1380

ctgtccaacg aaggcatcat caacagcgag gacgagcacc tgctggccct ggagagaaaa     1440

ctgaaaaaga tgctgggccc ctccgccgtg gagatcggca acggctgctt cgaaaccaag     1500

cacaaatgca atcaaacatg cctcgaccgg atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgctg cctccctcgg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgtccacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  37
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions - TEV cleavage site - 
       foldon - poly His

<400>  37
atgaaggcca ttatcgtgct cctgatggtg gtgacaagca atgctgacag aatttgcacc       60

gggatcacaa gcagcaacag ccctcacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagaggcaa gctgtgcccc aaatgtctga attgtaccga tctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacatc cggctgcttt cccattatgc acgaccggac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca taacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcgggag ctgccccaac      480

attaccaacg gcaacggctt ctttgccacc atggcctggg ctgtgcccaa gaacaaaacc      540

gctaccaacc ccctgaccat cgaggtgccc tatatttgca ccgaaggcga ggatcagatc      600

acagtctggg gctttcacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacaa cacactacgt gtcccaaatc      720

ggcggcttcc ccaatcagac cgaagatggg ggcctgcctc agagcggccg gatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaaag tgatcaaggg gtccctcccc      900

ctgatcggcg aggctgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcatgc caaggccatc ggcaactgcc ccatttgggt caagaccccc     1020

ctgaagctcg ccaacggcac caaatacaga cctcccgcca agctcctgaa ggagagaggc     1080

tttttcggcg ccatcgccgg cttcctggag gggggctggg aaggcatgat cgccggctgg     1140

cacggctaca catcccacgg cgcccacggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaaaat caccaagaac ctcaacagcc tgtccgagct ggaagtcaag     1260

aacctgcagc ggctgagcgg cgccatggac gaaccccaca acgagatcct cgagctggac     1320

gagaaggtgg acgacctgag agctgacacc atcagcagcc aaattgagct ggctgtgctg     1380

ctgtccaacg aaggcatcat caacagcgag gacgagcacc tgctggccct ggagagaaaa     1440

ctgaaaaaga tgctgggccc ctccgccgtg gagatcggca acggctgctt cgaaaccaag     1500

cacaaatgca atcaaacatg cctcgaccgg atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgctg cctccctcgg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgtccacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  38
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions - TEV cleavage site - 
       foldon - poly His.

<400>  38
atgaaggcca ttatcgtgct cctgatggtg gtgacaagca atgctgacag aatttgcacc       60

gggatcacaa gcagcaacag ccctcacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagaggcaa gctgtgcccc aaatgtctga attgtaccga tctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacatc cggctgcttt cccattatgc acgaccggac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca taacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcgggag ctgccccaac      480

attaccaacg gcaacggctt ctttgccacc atggcctggg ctgtgcccaa gaacaaaacc      540

gctaccaacc ccctgaccat cgaggtgccc tatatttgca ccgaaggcga ggatcagatc      600

acagtctggg gctttcacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacaa cacactacgt gtcccaaatc      720

ggcggcttcc ccaatcagac cgaagatggg ggcctgcctc agagcggccg gatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaaag tgatcaaggg gtccctcccc      900

ctgatcggcg aggctgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcatgc caaggccatc ggcaactgcc ccatttgggt caagaccccc     1020

ctgaagctcg ccaacggcac caaatacaga cctcccgcca agctcctgaa ggagagaggc     1080

tttttcggcg ccatcgccgg cttcctggag gggggctggg aaggcatgat cgccggctgg     1140

cacggctaca catcccacgg cgcccacggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaaaat caccaagaac ctcaacagcc tgtccgagct ggaagtcaag     1260

aacctgcagc ggctgagcgg cgcccctgac gaaccccaca acgagatcct cgagctggac     1320

gagaaggtgg acgacctgag agctgacacc atcagcagcc aaattgagct ggctgtgctg     1380

ctgtccaacg aaggcatcat caacagcgag gacgagcacc tgctggccct ggagagaaaa     1440

ctgaaaaaga tgctgggccc ctccgccgtg gagatcggca acggctgctt cgaaaccaag     1500

cacaaatgca atcaaacatg cctcgaccgg atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgctg cctccctcgg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgtccacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  39
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions - TEV cleavage site - 
       foldon - poly His

<400>  39
atgaaggcca ttatcgtgct cctgatggtg gtgacaagca atgctgacag aatttgcacc       60

gggatcacaa gcagcaacag ccctcacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagaggcaa gctgtgcccc aaatgtctga attgtaccga tctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacatc cggctgcttt cccattatgc acgaccggac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca taacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcgggag ctgccccaac      480

attaccaacg gcaacggctt ctttgccacc atggcctggg ctgtgcccaa gaacaaaacc      540

gctaccaacc ccctgaccat cgaggtgccc tatatttgca ccgaaggcga ggatcagatc      600

acagtctggg gctttcacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacaa cacactacgt gtcccaaatc      720

ggcggcttcc ccaatcagac cgaagatggg ggcctgcctc agagcggccg gatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaaag tgatcaaggg gtccctcccc      900

ctgatcggcg aggctgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcatgc caaggccatc ggcaactgcc ccatttgggt caagaccccc     1020

ctgaagctcg ccaacggcac caaatacaga cctcccgcca agctcctgaa ggagagaggc     1080

tttttcggcg ccatcgccgg cttcctggag gggggctggg aaggcatgat cgccggctgg     1140

cacggctaca catcccacgg cgcccacggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaaaat caccaagatg ctcaacagcc tgtccgagct ggaagtcaag     1260

aacctgcagc ggctgagcgg cgccatggac gaactgcaca acgagatcct cgagctggac     1320

gagaaggtgg acgacctgag agctgacacc atcagcagcc aaattgagct ggctgtgctg     1380

ctgtccaacg aaggcatcat caacagcgag gacgagcacc tgctggccct ggagagaaaa     1440

ctgaaaaaga tgctgggccc ctccgccgtg gagatcggca acggctgctt cgaaaccaag     1500

cacaaatgca atcaaacatg cctcgaccgg atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgctg cctccctcgg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgtccacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  40
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions - TEV cleavage site - 
       foldon - poly His.

<400>  40
atgaaggcca ttatcgtgct cctgatggtg gtgacaagca atgctgacag aatttgcacc       60

gggatcacaa gcagcaacag ccctcacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagaggcaa gctgtgcccc aaatgtctga attgtaccga tctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacatc cggctgcttt cccattatgc acgaccggac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca taacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcgggag ctgccccaac      480

attaccaacg gcaacggctt ctttgccacc atggcctggg ctgtgcccaa gaacaaaacc      540

gctaccaacc ccctgaccat cgaggtgccc tatatttgca ccgaaggcga ggatcagatc      600

acagtctggg gctttcacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacaa cacactacgt gtcccaaatc      720

ggcggcttcc ccaatcagac cgaagatggg ggcctgcctc agagcggccg gatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaaag tgatcaaggg gtccctcccc      900

ctgatcggcg aggctgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcatgc caaggccatc ggcaactgcc ccatttgggt caagaccccc     1020

ctgaagctcg ccaacggcac caaatacaga cctcccgcca agctcctgaa ggagagaggc     1080

tttttcggcg ccatcgccgg cttcctggag gggggctggg aaggcatgat cgccggctgg     1140

cacggctaca catcccacgg cgcccacggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaaaat caccaagaac ctcaacagcc tgtccgagct ggaagtcaag     1260

aacctgcagc ggctgagcgg cgccatggac gaactgcaca acgagatcct cgagctggac     1320

gagaaggtgg acgacctgag agctgacgtg atcagcagcc aaattgagct ggctgtgctg     1380

ctgtccaacg aaggcatcat caacagcgag gacgagcacc tgctggccct ggagagaaaa     1440

ctgaaaaaga tgctgggccc ctccgccgtg gagatcggca acggctgctt cgaaaccaag     1500

cacaaatgca atcaaacatg cctcgaccgg atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgctg cctccctcgg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgtccacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  41
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions - TEV cleavage site - 
       foldon - poly His.

<400>  41
atgaaggcca ttatcgtgct cctgatggtg gtgacaagca atgctgacag aatttgcacc       60

gggatcacaa gcagcaacag ccctcacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagaggcaa gctgtgcccc aaatgtctga attgtaccga tctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacatc cggctgcttt cccattatgc acgaccggac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca taacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcgggag ctgccccaac      480

attaccaacg gcaacggctt ctttgccacc atggcctggg ctgtgcccaa gaacaaaacc      540

gctaccaacc ccctgaccat cgaggtgccc tatatttgca ccgaaggcga ggatcagatc      600

acagtctggg gctttcacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacaa cacactacgt gtcccaaatc      720

ggcggcttcc ccaatcagac cgaagatggg ggcctgcctc agagcggccg gatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaaag tgatcaaggg gtccctcccc      900

ctgatcggcg aggctgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcatgc caaggccatc ggcaactgcc ccatttgggt caagaccccc     1020

ctgaagctcg ccaacggcac caaatacaga cctcccgcca agctcctgaa ggagagaggc     1080

tttttcggcg ccatcgccgg cttcctggag gggggctggg aaggcatgat cgccggctgg     1140

cacggctaca catcccacgg cgcccacggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaaaat caccaagaac ctcaacagcc tgtccgagct ggaagtcaag     1260

aacctgcagc ggctgagcgg cgccatggac gaactgcaca acgagatcct cgagctggac     1320

gagaaggtgg acgacctgag agctgacgtg atcagcagcc aaattgagct ggctgtgctg     1380

ctgtccaacg aaggcatcat caacagcgag gacgagcacc tgctggccct ggagagaaaa     1440

ctgaaaaaga tgctgggccc ctccgccgtg gagatcggca acggctgctt cgaaaccaag     1500

cacaaatgca atcaaacatg cctcgaccgg atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgctg cctccctcgg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgtccacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  42
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions - TEV cleavage site - 
       foldon - poly His.

<400>  42
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagagggaa gctgtgcccc aagtgcctga actgcaccga cctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacaag cggctgcttc cccatcatgc acgacagaac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca caacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcggcag ctgccccaac      480

atcaccaacg gcaacggctt cttcgccacc atggcctggg ccgtgcccaa gaacaagacc      540

gctaccaacc ctctgaccat cgaggtgccc tacatctgca ccgagggcga ggatcagatc      600

accgtgtggg gcttccacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacca cccactacgt gagccaaatc      720

ggcggcttcc ccaatcagac cgaggacggc ggcctgcctc agagcggcag aatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaagg tgatcaaggg cagcctgccc      900

ctgatcggcg aggccgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcacgc caaggccatc ggcaactgcc ccatctgggt gaagaccccc     1020

ctgaagctgg ccaacggcac caagtacaga ccccccgcca agctgctgaa ggagagaggg     1080

ttcttcggcg ccatcgccgg cttcctggag ggcggctggg aaggcatgat cgctgggtgg     1140

cacggctaca caagccacgg cgctcatggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaagat caccaagaac ctgaacagcc tgagcgagct ggaggtgaag     1260

aacctgcaga gactgagcgg cgccatggac gagctgcaca acgagatcct ggagctggac     1320

gagaaggtgg acgacctgag agccgacacc atcagcagcc aaatcgagct ggccgtgctg     1380

ctgagcaacg aggtgatcat caacagcgag gacgagcacc tgctggccct ggagagaaag     1440

ctgaagaaga tgctgggccc tagcgccgtg gagatcggga acggctgctt cgagaccaag     1500

cacaagtgca atcagacctg cctggacaga atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgccg ctagcctggg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgagcacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  43
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions - TEV cleavage site - 
       foldon - poly His.

<400>  43
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagagggaa gctgtgcccc aagtgcctga actgcaccga cctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacaag cggctgcttc cccatcatgc acgacagaac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca caacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcggcag ctgccccaac      480

atcaccaacg gcaacggctt cttcgccacc atggcctggg ccgtgcccaa gaacaagacc      540

gctaccaacc ctctgaccat cgaggtgccc tacatctgca ccgagggcga ggatcagatc      600

accgtgtggg gcttccacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacca cccactacgt gagccaaatc      720

ggcggcttcc ccaatcagac cgaggacggc ggcctgcctc agagcggcag aatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaagg tgatcaaggg cagcctgccc      900

ctgatcggcg aggccgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcacgc caaggccatc ggcaactgcc ccatctgggt gaagaccccc     1020

ctgaagctgg ccaacggcac caagtacaga ccccccgcca agctgctgaa ggagagaggg     1080

ttcttcggcg ccatcgccgg cttcctggag ggcggctggg aaggcatgat cgctgggtgg     1140

cacggctaca caagccacgg cgctcatggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaagat caccaagaac ctgaacagcc tgagcgagct ggaggtgaag     1260

aacctgcaga gactgagcgg cgccatggac gagctgcaca acgagatcct ggagctggac     1320

gagaaggtgg acgacctgag agccgacacc atcagcagcc aaatcgagct ggccgtgctg     1380

ctgagcaacg agctgatcat caacagcgag gacgagcacc tgctggccct ggagagaaag     1440

ctgaagaaga tgctgggccc tagcgccgtg gagatcggga acggctgctt cgagaccaag     1500

cacaagtgca atcagacctg cctggacaga atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgccg ctagcctggg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgagcacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  44
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions - TEV cleavage site - 
       foldon - poly His.

<400>  44
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagagggaa gctgtgcccc aagtgcctga actgcaccga cctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacaag cggctgcttc cccatcatgc acgacagaac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca caacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcggcag ctgccccaac      480

atcaccaacg gcaacggctt cttcgccacc atggcctggg ccgtgcccaa gaacaagacc      540

gctaccaacc ctctgaccat cgaggtgccc tacatctgca ccgagggcga ggatcagatc      600

accgtgtggg gcttccacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacca cccactacgt gagccaaatc      720

ggcggcttcc ccaatcagac cgaggacggc ggcctgcctc agagcggcag aatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaagg tgatcaaggg cagcctgccc      900

ctgatcggcg aggccgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcacgc caaggccatc ggcaactgcc ccatctgggt gaagaccccc     1020

ctgaagctgg ccaacggcac caagtacaga ccccccgcca agctgctgaa ggagagaggg     1080

ttcttcggcg ccatcgccgg cttcctggag ggcggctggg aaggcatgat cgctgggtgg     1140

cacggctaca caagccacgg cgctcatggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaagat caccaagaac ctgaacagcc tgagcgagct ggaggtgaag     1260

aacctgcaga gactgagcgg cgccatggac gagctgcaca acgagatcct ggagctggac     1320

gagaaggtgg acgacctgag agccgacacc atcagcagcc aaatcgagct ggccgtgctg     1380

ctgagcaacg agttcatcat caacagcgag gacgagcacc tgctggccct ggagagaaag     1440

ctgaagaaga tgctgggccc tagcgccgtg gagatcggga acggctgctt cgagaccaag     1500

cacaagtgca atcagacctg cctggacaga atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgccg ctagcctggg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgagcacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  45
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions - TEV cleavage site - 
       foldon - poly His.

<400>  45
atgaaggcca ttatcgtgct cctgatggtg gtgacaagca atgctgacag aatttgcacc       60

gggatcacaa gcagcaacag ccctcacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagaggcaa gctgtgcccc aaatgtctga attgtaccga tctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacatc cggctgcttt cccattatgc acgaccggac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca taacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcgggag ctgccccaac      480

attaccaacg gcaacggctt ctttgccacc atggcctggg ctgtgcccaa gaacaaaacc      540

gctaccaacc ccctgaccat cgaggtgccc tatatttgca ccgaaggcga ggatcagatc      600

acagtctggg gctttcacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacaa cacactacgt gtcccaaatc      720

ggcggcttcc ccaatcagac cgaagatggg ggcctgcctc agagcggccg gatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaaag tgatcaaggg gtccctcccc      900

ctgatcggcg aggctgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcatgc caaggccatc ggcaactgcc ccatttgggt caagaccccc     1020

ctgaagctcg ccaacggcac caaatacaga cctcccgcca agctcctgaa ggagagaggc     1080

tttttcggcg ccatcgccgg cttcctggag gggggctggg aaggcatgat cgccggctgg     1140

cacggctaca catcccacgg cgcccacggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaaaat caccaagaac ctcaacagcc tgtccgagct ggaagtcaag     1260

aacctgcagc ggctgagcgg cgccatggac gaactgcaca acgagatcct cgagctggac     1320

gagaaggtgg acgacctgag agctgacacc atcagcagcc aaattgagct ggctgtgctg     1380

ctgtccaacg aaggcatcat caacagcgag gacatccacc tgctggccct ggagagaaaa     1440

ctgaaaaaga tgctgggccc ctccgccgtg gagatcggca acggctgctt cgaaaccaag     1500

cacaaatgca atcaaacatg cctcgaccgg atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgctg cctccctcgg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgtccacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  46
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions - TEV cleavage site - 
       foldon - poly His.

<400>  46
atgaaggcca ttatcgtgct cctgatggtg gtgacaagca atgctgacag aatttgcacc       60

gggatcacaa gcagcaacag ccctcacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagaggcaa gctgtgcccc aaatgtctga attgtaccga tctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacatc cggctgcttt cccattatgc acgaccggac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca taacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcgggag ctgccccaac      480

attaccaacg gcaacggctt ctttgccacc atggcctggg ctgtgcccaa gaacaaaacc      540

gctaccaacc ccctgaccat cgaggtgccc tatatttgca ccgaaggcga ggatcagatc      600

acagtctggg gctttcacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacaa cacactacgt gtcccaaatc      720

ggcggcttcc ccaatcagac cgaagatggg ggcctgcctc agagcggccg gatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaaag tgatcaaggg gtccctcccc      900

ctgatcggcg aggctgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcatgc caaggccatc ggcaactgcc ccatttgggt caagaccccc     1020

ctgaagctcg ccaacggcac caaatacaga cctcccgcca agctcctgaa ggagagaggc     1080

tttttcggcg ccatcgccgg cttcctggag gggggctggg aaggcatgat cgccggctgg     1140

cacggctaca catcccacgg cgcccacggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaaaat caccaagaac ctcaacagcc tgtccgagct ggaagtcaag     1260

aacctgcagc ggctgagcgg cgccatggac gaactgcaca acgagatcct cgagctggac     1320

gagaaggtgg acgacctgag agctgacacc atcagcagcc aaattgagct ggctgtgctg     1380

ctgtccaacg aaatcatcat caacagcgag gacctgcacc tgctggccct ggagagaaaa     1440

ctgaaaaaga tgctgggccc ctccgccgtg gagatcggca acggctgctt cgaaaccaag     1500

cacaaatgca atcaaacatg cctcgaccgg atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgctg cctccctcgg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgtccacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  47
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions - TEV cleavage site - 
       foldon - poly His.

<400>  47
atgaaggcca ttatcgtgct cctgatggtg gtgacaagca atgctgacag aatttgcacc       60

gggatcacaa gcagcaacag ccctcacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagaggcaa gctgtgcccc aaatgtctga attgtaccga tctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacatc cggctgcttt cccattatgc acgaccggac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca taacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcgggag ctgccccaac      480

attaccaacg gcaacggctt ctttgccacc atggcctggg ctgtgcccaa gaacaaaacc      540

gctaccaacc ccctgaccat cgaggtgccc tatatttgca ccgaaggcga ggatcagatc      600

acagtctggg gctttcacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacaa cacactacgt gtcccaaatc      720

ggcggcttcc ccaatcagac cgaagatggg ggcctgcctc agagcggccg gatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaaag tgatcaaggg gtccctcccc      900

ctgatcggcg aggctgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcatgc caaggccatc ggcaactgcc ccatttgggt caagaccccc     1020

ctgaagctcg ccaacggcac caaatacaga cctcccgcca agctcctgaa ggagagaggc     1080

tttttcggcg ccatcgccgg cttcctggag gggggctggg aaggcatgat cgccggctgg     1140

cacggctaca catcccacgg cgcccacggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaaaat caccaagaac ctcaacagcc tgtccgagct ggaagtcaag     1260

aacctgcagc ggctgagcgg cgccatggac gaactgcaca acgagatcct cgagctggac     1320

gagaaggtgg acgacctgag agctgacacc atcagcagcc aaattgagct ggctgtgctg     1380

ctgtccaacg aaggcatcat caacagcgag gacgagcacc tgctggccca agagagaaaa     1440

ctgaaaaaga tgctgggccc ctccgccgtg gagatcggca acggctgctt cgaaaccaag     1500

cacaaatgca atcaaacatg cctcgaccgg atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgctg cctccctcgg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgtccacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  48
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions - TEV cleavage site - 
       foldon - poly His

<400>  48
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagagggaa gctgtgcccc aagtgcctga actgcaccga cctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacaag cggctgcttc cccatcatgc acgacagaac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca caacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcggcag ctgccccaac      480

atcaccaacg gcaacggctt cttcgccacc atggcctggg ccgtgcccaa gaacaagacc      540

gctaccaacc ctctgaccat cgaggtgccc tacatctgca ccgagggcga ggatcagatc      600

accgtgtggg gcttccacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacca cccactacgt gagccaaatc      720

ggcggcttcc ccaatcagac cgaggacggc ggcctgcctc agagcggcag aatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaagg tgatcaaggg cagcctgccc      900

ctgatcggcg aggccgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcacgc caaggccatc ggcaactgcc ccatctgggt gaagaccccc     1020

ctgaagctgg ccaacggcac caagtacaga ccccccgcca agctgctgaa ggagagaggg     1080

ttcttcggcg ccatcgccgg cttcctggag ggcggctggg aaggcatgat cgctgggtgg     1140

cacggctaca caagccacgg cgctcatggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaagat caccaagaac ctgaacagcc tgagcgagct ggaggtgaag     1260

aacctgcaga gactgagcgg cgccatggac gagctgcaca acgagatcct ggagctggac     1320

gagaaggtgg acgacctgag agccgacgtg atcagcagcc aaatcgagct ggccgtgctg     1380

ctgagcaacg agctgatcat caacagcgag gacgagcacc tgctggccct ggagagaaag     1440

ctgaagaaga tgctgggccc tagcgccgtg gagatcggga acggctgctt cgagaccaag     1500

cacaagtgca atcagacctg cctggacaga atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgccg ctagcctggg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgagcacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  49
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions - TEV cleavage site - 
       foldon - poly His.

<400>  49
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagagggaa gctgtgcccc aagtgcctga actgcaccga cctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacaag cggctgcttc cccatcatgc acgacagaac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca caacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcggcag ctgccccaac      480

atcaccaacg gcaacggctt cttcgccacc atggcctggg ccgtgcccaa gaacaagacc      540

gctaccaacc ctctgaccat cgaggtgccc tacatctgca ccgagggcga ggatcagatc      600

accgtgtggg gcttccacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacca cccactacgt gagccaaatc      720

ggcggcttcc ccaatcagac cgaggacggc ggcctgcctc agagcggcag aatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaagg tgatcaaggg cagcctgccc      900

ctgatcggcg aggccgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcacgc caaggccatc ggcaactgcc ccatctgggt gaagaccccc     1020

ctgaagctgg ccaacggcac caagtacaga ccccccgcca agctgctgaa ggagagaggg     1080

ttcttcggcg ccatcgccgg cttcctggag ggcggctggg aaggcatgat cgctgggtgg     1140

cacggctaca caagccacgg cgctcatggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaagat caccaagaac ctgaacagcc tgagcgagct ggaggtgaag     1260

aacctgcaga gactgagcgg cgccatggac gagctgcaca acgagatcct ggagctggac     1320

gagaaggtgg acgacctgag agccgacatg atcagcagcc aaatcgagct ggccgtgctg     1380

ctgagcaacg agttcatcat caacagcgag gacgagcacc tgctggccct ggagagaaag     1440

ctgaagaaga tgctgggccc tagcgccgtg gagatcggga acggctgctt cgagaccaag     1500

cacaagtgca atcagacctg cctggacaga atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgccg ctagcctggg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgagcacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  50
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions - TEV cleavage site - 
       foldon - poly His

<400>  50
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagagggaa gctgtgcccc aagtgcctga actgcaccga cctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacaag cggctgcttc cccatcatgc acgacagaac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca caacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcggcag ctgccccaac      480

atcaccaacg gcaacggctt cttcgccacc atggcctggg ccgtgcccaa gaacaagacc      540

gctaccaacc ctctgaccat cgaggtgccc tacatctgca ccgagggcga ggatcagatc      600

accgtgtggg gcttccacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacca cccactacgt gagccaaatc      720

ggcggcttcc ccaatcagac cgaggacggc ggcctgcctc agagcggcag aatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaagg tgatcaaggg cagcctgccc      900

ctgatcggcg aggccgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcacgc caaggccatc ggcaactgcc ccatctgggt gaagaccccc     1020

ctgaagctgg ccaacggcac caagtacaga ccccccgcca agctgctgaa ggagagaggg     1080

ttcttcggcg ccatcgccgg cttcctggag ggcggctggg aaggcatgat cgctgggtgg     1140

cacggctaca caagccacgg cgctcatggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaagat caccaagatg ctgaacagcc tgagcgagct ggaggtgaag     1260

aacctgcaga gactgagcgg cgccatggac gagctgcaca acgagatcct ggagctggac     1320

gagaaggtgg acgacctgag agccgacatg atcagcagcc aaatcgagct ggccgtgctg     1380

ctggtgaacg agggcatcat caacagcgag gacgagcacc tgctggccct ggagagaaag     1440

ctgaagaaga tgctgggccc tagcgccgtg gagatcggga acggctgctt cgagaccaag     1500

cacaagtgca atcagacctg cctggacaga atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgccg ctagcctggg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgagcacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  51
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions - TEV cleavage site - 
       foldon - poly His

<400>  51
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagagggaa gctgtgcccc aagtgcctga actgcaccga cctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacaag cggctgcttc cccatcatgc acgacagaac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca caacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcggcag ctgccccaac      480

atcaccaacg gcaacggctt cttcgccacc atggcctggg ccgtgcccaa gaacaagacc      540

gctaccaacc ctctgaccat cgaggtgccc tacatctgca ccgagggcga ggatcagatc      600

accgtgtggg gcttccacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacca cccactacgt gagccaaatc      720

ggcggcttcc ccaatcagac cgaggacggc ggcctgcctc agagcggcag aatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaagg tgatcaaggg cagcctgccc      900

ctgatcggcg aggccgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcacgc caaggccatc ggcaactgcc ccatctgggt gaagaccccc     1020

ctgaagctgg ccaacggcac caagtacaga ccccccgcca agctgctgaa ggagagaggg     1080

ttcttcggcg ccatcgccgg cttcctggag ggcggctggg aaggcatgat cgctgggtgg     1140

cacggctaca caagccacgg cgctcatggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaagat caccaagatg ctgaacagcc tgagcgagct ggaggtgaag     1260

aacctgcaga gactgagcgg cgccatggac gagctgcaca acgagatcct ggagctggac     1320

gagaaggtgg acgacctgag agccgacacc atcagcagcc aaatcgagct ggccgtgctg     1380

ctggtgaacg agggcatcat caacagcgag gacgtgcacc tgctggccct ggagagaaag     1440

ctgaagaaga tgctgggccc tagcgccgtg gagatcggga acggctgctt cgagaccaag     1500

cacaagtgca atcagacctg cctggacaga atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgccg ctagcctggg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgagcacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  52
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions - TEV cleavage site - 
       foldon - poly His

<400>  52
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagagggaa gctgtgcccc aagtgcctga actgcaccga cctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacaag cggctgcttc cccatcatgc acgacagaac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca caacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcggcag ctgccccaac      480

atcaccaacg gcaacggctt cttcgccacc atggcctggg ccgtgcccaa gaacaagacc      540

gctaccaacc ctctgaccat cgaggtgccc tacatctgca ccgagggcga ggatcagatc      600

accgtgtggg gcttccacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacca cccactacgt gagccaaatc      720

ggcggcttcc ccaatcagac cgaggacggc ggcctgcctc agagcggcag aatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaagg tgatcaaggg cagcctgccc      900

ctgatcggcg aggccgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcacgc caaggccatc ggcaactgcc ccatctgggt gaagaccccc     1020

ctgaagctgg ccaacggcac caagtacaga ccccccgcca agctgctgaa ggagagaggg     1080

ttcttcggcg ccatcgccgg cttcctggag ggcggctggg aaggcatgat cgctgggtgg     1140

cacggctaca caagccacgg cgctcatggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaagat caccaagatg ctgaacagcc tgagcgagct ggaggtgaag     1260

aacctgcaga gactgagcgg cgccatggac gagctgcaca acgagatcct ggagctggac     1320

gagaaggtgg acgacctgag agccgacatg atcagcagcc aaatcgagct ggccgtgctg     1380

ctggtgaacg agggcatcat caacagcgag gacgtgcacc tgctggccct ggagagaaag     1440

ctgaagaaga tgctgggccc tagcgccgtg gagatcggga acggctgctt cgagaccaag     1500

cacaagtgca atcagacctg cctggacaga atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgccg ctagcctggg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgagcacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  53
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  53

Gly Ser Gly Ser 
1               


<210>  54
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  54

Gly Ser Pro Gly 
1               


<210>  55
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  55

Gly Pro Ser Gly 
1               


<210>  56
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  56

Gly Pro Ser Pro Gly 
1               5   


<210>  57
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  57

Gly Ser Gly Ser Gly 
1               5   


<210>  58
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  58

Gly Ser Gly Gly Ser Gly 
1               5       


<210>  59
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  59

Asp Val Ala Asn Lys Val Ser Lys Ala Thr Asp Gly Ser Gly 
1               5                   10                  


<210>  60
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  60

Asp Val Ala Asn Lys Val Ser Lys Ala Thr Asp Gly Ser Gly Gly 
1               5                   10                  15  


<210>  61
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  61

Asp Val Ala Asn Lys Val Ser Lys Ala Gly Ser 
1               5                   10      


<210>  62
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  62

Asp Val Ala Asn Lys Val Ser Lys Ala Gly Gly 
1               5                   10      


<210>  63
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  63

Ala Ser Thr Gly 
1               


<210>  64
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  64

Ile Pro Gly Thr Gly Thr 
1               5       


<210>  65
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  65

Leu Pro Thr Ser 
1               


<210>  66
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  66

Tyr Ala Asp Gly Gly 
1               5   


<210>  67
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  67

Leu Lys Gly Thr Gly Gly 
1               5       


<210>  68
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  68

Gln Ser Gly Gly 
1               


<210>  69
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  69

Thr Pro Ser Gly Ser 
1               5   


<210>  70
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  70

Asp Gln Thr Thr Gln Thr 
1               5       


<210>  71
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  71

Ile Ala Gly Pro Gln Gly Ser Val 
1               5               


<210>  72
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  72

Leu Thr Val Asn Gly Glu Asp Val Gly 
1               5                   


<210>  73
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  73

Val Ala Ile Pro Asn Thr Ser Tyr Val Val 
1               5                   10  


<210>  74
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  74

Phe Glu Asn Asn Leu Phe Arg Ala 
1               5               


<210>  75
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  75

Val Ala Phe Asn Asn Asp Asn Asn Gln 
1               5                   


<210>  76
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  76

Ser Thr Tyr Ala Ala Ile Gly Asn Ala Leu 
1               5                   10  


<210>  77
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  77

Ser Lys Ile Leu Thr Gly Asp Tyr Thr Ser 
1               5                   10  


<210>  78
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  78

Ser Ala Phe Tyr Glu Ala Phe Pro Gly Ala Thr 
1               5                   10      


<210>  79
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  79

Ser Ala Thr Leu Asp Glu Ile Pro Ser Leu Lys Glu 
1               5                   10          


<210>  80
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  80

Ser Glu Ser Phe Lys Gln Thr Glu Gly Gln Pro Ala 
1               5                   10          


<210>  81
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  81

Ser Glu Thr Val Ala Lys Trp Glu Lys Gln Leu Ala Ala Gly Asp Pro 
1               5                   10                  15      


<210>  82
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  82

Ser Asn Ala Met Ser Lys Leu Ala Gln Gln Phe Thr Asp Gln Pro Thr 
1               5                   10                  15      


Pro 
    


<210>  83
<211>  536
<212>  PRT
<213>  Influenza B virus

<400>  83

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu 
    530                 535     


<210>  84
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions  TEV cleavage site  foldon  poly His.

<400>  84

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Leu Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  85
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions  TEV cleavage site  foldon  poly His.

<400>  85

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  86
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions  TEV cleavage site  foldon  poly His.

<400>  86

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Pro Asp Glu Pro 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Leu Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  87
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions  TEV cleavage site  foldon  poly His.

<400>  87

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Val Asn Glu 
    450                 455                 460                 


Leu Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  88
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions  TEV cleavage site  foldon  poly His.

<400>  88

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Ile His Leu Leu Ala Gln Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  89
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions  TEV cleavage site  foldon  poly His.

<400>  89

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Leu His Leu Leu Ala Gln Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  90
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions  TEV cleavage site  foldon  poly His.

<400>  90

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Ile Ile Ile Asn Ser Glu Asp Ile His Leu Leu Ala Gln Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  91
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions  TEV cleavage site  foldon  poly His.

<400>  91

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Phe Ile Ile Asn Ser Glu Asp Ile His Leu Leu Ala Gln Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  92
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions  TEV cleavage site  foldon  poly His.

<400>  92

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Ile Ile Ile Asn Ser Glu Asp Leu His Leu Leu Ala Gln Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  93
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions  TEV cleavage site  foldon  poly His.

<400>  93

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Phe Ile Ile Asn Ser Glu Asp Leu His Leu Leu Ala Gln Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  94
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions  TEV cleavage site  foldon  poly His.

<400>  94

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Pro Asp Glu Pro 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Val Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  95
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions  TEV cleavage site  foldon  poly His.

<400>  95

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Pro Asp Glu Pro 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Val Asn Glu 
    450                 455                 460                 


Leu Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln 
    530                 535                 540                 


Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
545                 550                 555                 560 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
                565                 570                 575     


His His His His His His 
            580         


<210>  96
<211>  273
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  96

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Gly Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys 
    50                  55                  60                  


Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu 
65                  70                  75                  80  


Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His 
                85                  90                  95      


Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu 
            100                 105                 110         


Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu 
        115                 120                 125             


Val Lys Asn Gly Ser Gly Ser Asp Leu Arg Ala Asp Thr Ile Ser Ser 
    130                 135                 140                 


Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu Val Ile Ile Asn Ser 
145                 150                 155                 160 


Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys Leu Lys Lys Met Leu 
                165                 170                 175     


Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys Phe Glu Thr Lys His 
            180                 185                 190         


Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asp 
        195                 200                 205             


Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala 
    210                 215                 220                 


Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln Gly Gly Ser Lys Gly 
225                 230                 235                 240 


Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp 
                245                 250                 255     


Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly His His His His His 
            260                 265                 270         


His 
    


<210>  97
<211>  273
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  97

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Gly Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys 
    50                  55                  60                  


Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu 
65                  70                  75                  80  


Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His 
                85                  90                  95      


Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu 
            100                 105                 110         


Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu 
        115                 120                 125             


Val Lys Asn Gly Ser Gly Ser Asp Leu Arg Ala Asp Thr Ile Ser Ser 
    130                 135                 140                 


Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu Phe Ile Ile Asn Ser 
145                 150                 155                 160 


Glu Asp Glu His Leu Leu Ala Gln Glu Arg Lys Leu Lys Lys Met Leu 
                165                 170                 175     


Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys Phe Glu Thr Lys His 
            180                 185                 190         


Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asp 
        195                 200                 205             


Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala 
    210                 215                 220                 


Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln Gly Gly Ser Lys Gly 
225                 230                 235                 240 


Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp 
                245                 250                 255     


Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly His His His His His 
            260                 265                 270         


His 
    


<210>  98
<211>  273
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  98

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Gly Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys 
    50                  55                  60                  


Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu 
65                  70                  75                  80  


Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His 
                85                  90                  95      


Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu 
            100                 105                 110         


Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Glu Leu Glu 
        115                 120                 125             


Val Lys Asn Gly Ser Gly Ser Asp Leu Arg Ala Asp Thr Ile Ser Ser 
    130                 135                 140                 


Gln Ile Glu Leu Ala Val Leu Leu Val Asn Glu Val Ile Ile Asn Ser 
145                 150                 155                 160 


Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys Leu Lys Lys Met Leu 
                165                 170                 175     


Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys Phe Glu Thr Lys His 
            180                 185                 190         


Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asp 
        195                 200                 205             


Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala 
    210                 215                 220                 


Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln Gly Gly Ser Lys Gly 
225                 230                 235                 240 


Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp 
                245                 250                 255     


Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly His His His His His 
            260                 265                 270         


His 
    


<210>  99
<211>  273
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  99

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Gly Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys 
    50                  55                  60                  


Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu 
65                  70                  75                  80  


Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His 
                85                  90                  95      


Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu 
            100                 105                 110         


Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Glu Leu Glu 
        115                 120                 125             


Val Lys Asn Gly Ser Gly Ser Asp Leu Arg Ala Asp Thr Ile Ser Ser 
    130                 135                 140                 


Gln Ile Glu Leu Ala Val Leu Leu Val Asn Glu Phe Ile Ile Asn Ser 
145                 150                 155                 160 


Glu Asp Glu His Leu Leu Ala Gln Glu Arg Lys Leu Lys Lys Met Leu 
                165                 170                 175     


Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys Phe Glu Thr Lys His 
            180                 185                 190         


Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asp 
        195                 200                 205             


Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala 
    210                 215                 220                 


Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln Gly Gly Ser Lys Gly 
225                 230                 235                 240 


Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp 
                245                 250                 255     


Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly His His His His His 
            260                 265                 270         


His 
    


<210>  100
<211>  263
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  100

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys Leu 
    50                  55                  60                  


Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly 
65                  70                  75                  80  


Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly 
                85                  90                  95      


Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala 
            100                 105                 110         


Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Glu Leu Glu Gly 
        115                 120                 125             


Ser Gly Ser Gly Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Val Asn 
    130                 135                 140                 


Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln Glu Arg 
145                 150                 155                 160 


Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly 
                165                 170                 175     


Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile 
            180                 185                 190         


Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp 
        195                 200                 205             


Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe 
    210                 215                 220                 


Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln 
225                 230                 235                 240 


Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
                245                 250                 255     


Gly His His His His His His 
            260             


<210>  101
<211>  265
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  101

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Gly Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys 
    50                  55                  60                  


Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu 
65                  70                  75                  80  


Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His 
                85                  90                  95      


Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu 
            100                 105                 110         


Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Glu Leu Glu 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    130                 135                 140                 


Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
145                 150                 155                 160 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                165                 170                 175     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            180                 185                 190         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        195                 200                 205             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu 
    210                 215                 220                 


Tyr Phe Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
225                 230                 235                 240 


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
                245                 250                 255     


Phe Leu Gly His His His His His His 
            260                 265 


<210>  102
<211>  265
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  102

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Gly Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys 
    50                  55                  60                  


Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu 
65                  70                  75                  80  


Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His 
                85                  90                  95      


Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu 
            100                 105                 110         


Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Glu Leu Glu 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    130                 135                 140                 


Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln 
145                 150                 155                 160 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                165                 170                 175     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            180                 185                 190         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        195                 200                 205             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu 
    210                 215                 220                 


Tyr Phe Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
225                 230                 235                 240 


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
                245                 250                 255     


Phe Leu Gly His His His His His His 
            260                 265 


<210>  103
<211>  273
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  103

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Gly Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys 
    50                  55                  60                  


Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu 
65                  70                  75                  80  


Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His 
                85                  90                  95      


Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu 
            100                 105                 110         


Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu 
        115                 120                 125             


Val Lys Asn Gly Ser Gly Ser Asp Ser Arg Ala Asp Val Ile Ser Ser 
    130                 135                 140                 


Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu Gly Ile Ile Asn Ser 
145                 150                 155                 160 


Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys Leu Lys Lys Met Leu 
                165                 170                 175     


Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys Phe Glu Thr Lys His 
            180                 185                 190         


Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asp 
        195                 200                 205             


Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala 
    210                 215                 220                 


Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln Gly Gly Ser Lys Gly 
225                 230                 235                 240 


Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp 
                245                 250                 255     


Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly His His His His His 
            260                 265                 270         


His 
    


<210>  104
<211>  273
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  104

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Gly Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys 
    50                  55                  60                  


Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu 
65                  70                  75                  80  


Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His 
                85                  90                  95      


Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu 
            100                 105                 110         


Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu 
        115                 120                 125             


Ser Lys Asn Gly Ser Gly Ser Asp Gln Arg Ala Asp Val Asn Ser Ser 
    130                 135                 140                 


Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu Gly Ile Ile Asn Ser 
145                 150                 155                 160 


Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys Leu Lys Lys Met Leu 
                165                 170                 175     


Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys Phe Glu Thr Lys His 
            180                 185                 190         


Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asp 
        195                 200                 205             


Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala 
    210                 215                 220                 


Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln Gly Gly Ser Lys Gly 
225                 230                 235                 240 


Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp 
                245                 250                 255     


Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly His His His His His 
            260                 265                 270         


His 
    


<210>  105
<211>  273
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  105

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Gly Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys 
    50                  55                  60                  


Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu 
65                  70                  75                  80  


Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His 
                85                  90                  95      


Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu 
            100                 105                 110         


Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu 
        115                 120                 125             


Ser Lys Asn Gly Ser Gly Ser Asp Gln Arg Ala Asp Val Asn Ser Ser 
    130                 135                 140                 


Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu Leu Ile Ile Asn Ser 
145                 150                 155                 160 


Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys Leu Lys Lys Met Leu 
                165                 170                 175     


Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys Phe Glu Thr Lys His 
            180                 185                 190         


Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asp 
        195                 200                 205             


Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala 
    210                 215                 220                 


Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe Gln Gly Gly Ser Lys Gly 
225                 230                 235                 240 


Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp 
                245                 250                 255     


Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly His His His His His 
            260                 265                 270         


His 
    


<210>  106
<211>  264
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem  TEV cleavage site 
       foldon  poly His.

<400>  106

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Gly Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys 
    50                  55                  60                  


Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu 
65                  70                  75                  80  


Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His 
                85                  90                  95      


Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu 
            100                 105                 110         


Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Asp Val Ala Asn Lys Val 
        115                 120                 125             


Ser Lys Ala Gly Ser Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
    130                 135                 140                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
145                 150                 155                 160 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn 
                165                 170                 175     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            180                 185                 190         


Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        195                 200                 205             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr 
    210                 215                 220                 


Phe Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly 
225                 230                 235                 240 


Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe 
                245                 250                 255     


Leu Gly His His His His His His 
            260                 


<210>  107
<211>  264
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem  TEV cleavage site 
       foldon  poly His.

<400>  107

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Gly Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys 
    50                  55                  60                  


Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu 
65                  70                  75                  80  


Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His 
                85                  90                  95      


Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu 
            100                 105                 110         


Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Asp Val Ala Asn Lys Val 
        115                 120                 125             


Ser Lys Ala Gly Gly Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
    130                 135                 140                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
145                 150                 155                 160 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn 
                165                 170                 175     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            180                 185                 190         


Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        195                 200                 205             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr 
    210                 215                 220                 


Phe Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly 
225                 230                 235                 240 


Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe 
                245                 250                 255     


Leu Gly His His His His His His 
            260                 


<210>  108
<211>  263
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  108

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Ala Ser 
        35                  40                  45              


Thr Gly Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys Leu 
    50                  55                  60                  


Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly 
65                  70                  75                  80  


Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly 
                85                  90                  95      


Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala 
            100                 105                 110         


Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Lys Ile Leu Thr 
        115                 120                 125             


Gly Asp Tyr Thr Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Val Asn 
    130                 135                 140                 


Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln Glu Arg 
145                 150                 155                 160 


Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly 
                165                 170                 175     


Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile 
            180                 185                 190         


Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp 
        195                 200                 205             


Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr Phe 
    210                 215                 220                 


Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln 
225                 230                 235                 240 


Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
                245                 250                 255     


Gly His His His His His His 
            260             


<210>  109
<211>  265
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  109

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Ile Pro 
        35                  40                  45              


Gly Thr Gly Thr Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala 
    50                  55                  60                  


Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu 
65                  70                  75                  80  


Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser 
                85                  90                  95      


His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln 
            100                 105                 110         


Glu Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Lys Ile 
        115                 120                 125             


Leu Thr Gly Asp Tyr Thr Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    130                 135                 140                 


Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln 
145                 150                 155                 160 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                165                 170                 175     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            180                 185                 190         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        195                 200                 205             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu 
    210                 215                 220                 


Tyr Phe Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
225                 230                 235                 240 


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
                245                 250                 255     


Phe Leu Gly His His His His His His 
            260                 265 


<210>  110
<211>  264
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  110

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Pro 
        35                  40                  45              


Thr Ser Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys Leu 
    50                  55                  60                  


Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly 
65                  70                  75                  80  


Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly 
                85                  90                  95      


Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala 
            100                 105                 110         


Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Ala Phe Tyr Glu 
        115                 120                 125             


Ala Phe Pro Gly Ala Thr Ser Gln Ile Glu Leu Ala Val Leu Leu Val 
    130                 135                 140                 


Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln Glu 
145                 150                 155                 160 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn 
                165                 170                 175     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            180                 185                 190         


Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        195                 200                 205             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr 
    210                 215                 220                 


Phe Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly 
225                 230                 235                 240 


Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe 
                245                 250                 255     


Leu Gly His His His His His His 
            260                 


<210>  111
<211>  265
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  111

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Tyr Ala 
        35                  40                  45              


Asp Gly Gly Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys 
    50                  55                  60                  


Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu 
65                  70                  75                  80  


Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His 
                85                  90                  95      


Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu 
            100                 105                 110         


Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Ala Phe Tyr 
        115                 120                 125             


Glu Ala Phe Pro Gly Ala Thr Ser Gln Ile Glu Leu Ala Val Leu Leu 
    130                 135                 140                 


Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln 
145                 150                 155                 160 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                165                 170                 175     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            180                 185                 190         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        195                 200                 205             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu 
    210                 215                 220                 


Tyr Phe Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
225                 230                 235                 240 


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
                245                 250                 255     


Phe Leu Gly His His His His His His 
            260                 265 


<210>  112
<211>  266
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  112

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Lys 
        35                  40                  45              


Gly Thr Gly Gly Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala 
    50                  55                  60                  


Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu 
65                  70                  75                  80  


Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser 
                85                  90                  95      


His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln 
            100                 105                 110         


Glu Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Ala Phe 
        115                 120                 125             


Tyr Glu Ala Phe Pro Gly Ala Thr Ser Gln Ile Glu Leu Ala Val Leu 
    130                 135                 140                 


Leu Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala 
145                 150                 155                 160 


Gln Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile 
                165                 170                 175     


Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu 
            180                 185                 190         


Asp Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro 
        195                 200                 205             


Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn 
    210                 215                 220                 


Leu Tyr Phe Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg 
225                 230                 235                 240 


Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser 
                245                 250                 255     


Thr Phe Leu Gly His His His His His His 
            260                 265     


<210>  113
<211>  265
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  113

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Gln Ser 
        35                  40                  45              


Gly Gly Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys Leu 
    50                  55                  60                  


Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly 
65                  70                  75                  80  


Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly 
                85                  90                  95      


Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala 
            100                 105                 110         


Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Ala Thr Leu Asp 
        115                 120                 125             


Arg Ile Pro Ser Leu Lys Glu Ser Gln Ile Glu Leu Ala Val Leu Leu 
    130                 135                 140                 


Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln 
145                 150                 155                 160 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                165                 170                 175     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            180                 185                 190         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        195                 200                 205             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu 
    210                 215                 220                 


Tyr Phe Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
225                 230                 235                 240 


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
                245                 250                 255     


Phe Leu Gly His His His His His His 
            260                 265 


<210>  114
<211>  266
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  114

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Thr Pro 
        35                  40                  45              


Ser Gly Ser Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys 
    50                  55                  60                  


Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu 
65                  70                  75                  80  


Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His 
                85                  90                  95      


Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu 
            100                 105                 110         


Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Ala Thr Leu 
        115                 120                 125             


Asp Glu Ile Pro Ser Leu Lys Glu Ser Gln Ile Glu Leu Ala Val Leu 
    130                 135                 140                 


Leu Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala 
145                 150                 155                 160 


Gln Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile 
                165                 170                 175     


Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu 
            180                 185                 190         


Asp Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro 
        195                 200                 205             


Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn 
    210                 215                 220                 


Leu Tyr Phe Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg 
225                 230                 235                 240 


Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser 
                245                 250                 255     


Thr Phe Leu Gly His His His His His His 
            260                 265     


<210>  115
<211>  267
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  115

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Asp Gln 
        35                  40                  45              


Thr Thr Gln Thr Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala 
    50                  55                  60                  


Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu 
65                  70                  75                  80  


Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser 
                85                  90                  95      


His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln 
            100                 105                 110         


Glu Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Glu Ser 
        115                 120                 125             


Phe Lys Gln Thr Glu Gly Gln Pro Ala Ser Gln Ile Glu Leu Ala Val 
    130                 135                 140                 


Leu Leu Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu 
145                 150                 155                 160 


Ala Gln Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu 
                165                 170                 175     


Ile Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys 
            180                 185                 190         


Leu Asp Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu 
        195                 200                 205             


Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu 
    210                 215                 220                 


Asn Leu Tyr Phe Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro 
225                 230                 235                 240 


Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu 
                245                 250                 255     


Ser Thr Phe Leu Gly His His His His His His 
            260                 265         


<210>  116
<211>  280
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  116

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Ile Ala 
        35                  40                  45              


Gly Pro Gln Gly Ser Val Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro 
    50                  55                  60                  


Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly 
65                  70                  75                  80  


Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr 
                85                  90                  95      


Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser 
            100                 105                 110         


Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser 
        115                 120                 125             


Glu Thr Val Ala Lys Trp Glu Lys Gln Leu Ala Ala Gly Asp Pro Ser 
    130                 135                 140                 


Ala Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Val 
145                 150                 155                 160 


Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln Glu 
                165                 170                 175     


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn 
            180                 185                 190         


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
        195                 200                 205             


Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe 
    210                 215                 220                 


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu Tyr 
225                 230                 235                 240 


Phe Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly 
                245                 250                 255     


Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe 
            260                 265                 270         


Leu Gly His His His His His His 
        275                 280 


<210>  117
<211>  281
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  117

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Val Asn Gly Glu Asp Val Gly Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
    50                  55                  60                  


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
65                  70                  75                  80  


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
                85                  90                  95      


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
            100                 105                 110         


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu 
        115                 120                 125             


Ser Glu Thr Val Ala Lys Trp Glu Lys Gln Leu Ala Ala Gly Asp Pro 
    130                 135                 140                 


Ser Ala Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
145                 150                 155                 160 


Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln 
                165                 170                 175     


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
            180                 185                 190         


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
        195                 200                 205             


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
    210                 215                 220                 


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu 
225                 230                 235                 240 


Tyr Phe Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
                245                 250                 255     


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
            260                 265                 270         


Phe Leu Gly His His His His His His 
        275                 280     


<210>  118
<211>  282
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  118

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Val Ala 
        35                  40                  45              


Ile Pro Asn Thr Ser Tyr Val Val Lys Leu Ala Asn Gly Thr Lys Tyr 
    50                  55                  60                  


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
65                  70                  75                  80  


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
                85                  90                  95      


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
            100                 105                 110         


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser 
        115                 120                 125             


Leu Ser Glu Thr Val Ala Lys Trp Glu Lys Gln Leu Ala Ala Gly Asp 
    130                 135                 140                 


Pro Ser Ala Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu 
145                 150                 155                 160 


Leu Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala 
                165                 170                 175     


Gln Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile 
            180                 185                 190         


Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu 
        195                 200                 205             


Asp Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro 
    210                 215                 220                 


Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn 
225                 230                 235                 240 


Leu Tyr Phe Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg 
                245                 250                 255     


Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser 
            260                 265                 270         


Thr Phe Leu Gly His His His His His His 
        275                 280         


<210>  119
<211>  281
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  119

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Phe Glu 
        35                  40                  45              


Asn Asn Leu Phe Arg Ala Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro 
    50                  55                  60                  


Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly 
65                  70                  75                  80  


Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr 
                85                  90                  95      


Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser 
            100                 105                 110         


Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser 
        115                 120                 125             


Asn Ala Met Ser Lys Leu Ala Gln Gln Phe Thr Asp Gln Pro Thr Pro 
    130                 135                 140                 


Ser Ala Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
145                 150                 155                 160 


Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln 
                165                 170                 175     


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
            180                 185                 190         


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
        195                 200                 205             


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
    210                 215                 220                 


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn Leu 
225                 230                 235                 240 


Tyr Phe Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
                245                 250                 255     


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
            260                 265                 270         


Phe Leu Gly His His His His His His 
        275                 280     


<210>  120
<211>  282
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  120

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Val Ala 
        35                  40                  45              


Phe Asn Asn Asp Asn Asn Gln Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
    50                  55                  60                  


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
65                  70                  75                  80  


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
                85                  90                  95      


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
            100                 105                 110         


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu 
        115                 120                 125             


Ser Asn Ala Met Ser Lys Leu Ala Gln Gln Phe Thr Asp Gln Pro Thr 
    130                 135                 140                 


Pro Ser Ala Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu 
145                 150                 155                 160 


Leu Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala 
                165                 170                 175     


Gln Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile 
            180                 185                 190         


Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu 
        195                 200                 205             


Asp Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro 
    210                 215                 220                 


Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu Asn 
225                 230                 235                 240 


Leu Tyr Phe Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro Arg 
                245                 250                 255     


Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser 
            260                 265                 270         


Thr Phe Leu Gly His His His His His His 
        275                 280         


<210>  121
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem with amino acid 
       substitutions  TEV cleavage site  foldon  poly His.

<400>  121

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Ser Thr 
        35                  40                  45              


Tyr Ala Ala Ile Gly Asn Ala Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
    50                  55                  60                  


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
65                  70                  75                  80  


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
                85                  90                  95      


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
            100                 105                 110         


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser 
        115                 120                 125             


Leu Ser Asn Ala Met Ser Lys Leu Ala Gln Gln Phe Thr Asp Gln Pro 
    130                 135                 140                 


Thr Pro Ser Ala Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val 
145                 150                 155                 160 


Leu Leu Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu 
                165                 170                 175     


Ala Gln Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu 
            180                 185                 190         


Ile Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys 
        195                 200                 205             


Leu Asp Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu 
    210                 215                 220                 


Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Gly Ser Glu 
225                 230                 235                 240 


Asn Leu Tyr Phe Gln Gly Gly Ser Lys Gly Tyr Ile Pro Glu Ala Pro 
                245                 250                 255     


Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu 
            260                 265                 270         


Ser Thr Phe Leu Gly His His His His His His 
        275                 280             


<210>  122
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions  TEV cleavage site - 
       foldon  poly His.

<400>  122
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ctacacaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagagggaa gctgtgcccc aagtgcctga actgcaccga cctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacaag cggctgcttc cccatcatgc acgacagaac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca caacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcggcag ctgccccaac      480

atcaccaacg gcaacggctt cttcgccacc atggcctggg ccgtgcccaa gaacaagacc      540

gccaccaatc ctctgaccat cgaggtgccc tacatctgca ccgagggcga ggatcagatc      600

accgtgtggg gcttccacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacca cccactacgt gagccaaatc      720

ggcggcttcc ccaatcagac cgaggacggc ggcctgcctc agagcggcag aatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaagg tgatcaaggg cagcctgccc      900

ctgatcggcg aggccgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcacgc caaggccatc ggcaactgcc ccatctgggt gaagaccccc     1020

ctgaagctgg ccaacggcac caagtacaga ccccccgcca agctgctgaa ggagcggggc     1080

ttcttcgggg ccatcgccgg ctttctcgag ggcggctggg aggggatgat cgctgggtgg     1140

cacgggtaca caagccatgg cgcccacggc gtggccgtgg ccgccgacct caagagcacc     1200

caagaggcca tcaacaagat caccaagaac ctgaacagcc tgagcgagct ggaggtgaag     1260

aacctgcaga gactgagcgg cgccatggac gagctgcaca acgagatcct ggagctggac     1320

gagaaggtgg acgacctgag agccgacacc atcagcagcc aaatcgagct ggccgtcctc     1380

ctgtccaacg agctgatcat caacagcgag gacgagcacc tgctggccca agagagaaag     1440

ctgaagaaga tgctgggccc tagcgccgtg gagatcggga acggctgctt cgagaccaag     1500

cacaagtgca atcagacctg cctggacaga atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgccg ctagcctggg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgagcacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  123
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions  TEV cleavage site - 
       foldon  poly His.

<400>  123
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ctacacaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagagggaa gctgtgcccc aagtgcctga actgcaccga cctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacaag cggctgcttc cccatcatgc acgacagaac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca caacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcggcag ctgccccaac      480

atcaccaacg gcaacggctt cttcgccacc atggcctggg ccgtgcccaa gaacaagacc      540

gccaccaatc ctctgaccat cgaggtgccc tacatctgca ccgagggcga ggatcagatc      600

accgtgtggg gcttccacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacca cccactacgt gagccaaatc      720

ggcggcttcc ccaatcagac cgaggacggc ggcctgcctc agagcggcag aatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaagg tgatcaaggg cagcctgccc      900

ctgatcggcg aggccgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcacgc caaggccatc ggcaactgcc ccatctgggt gaagaccccc     1020

ctgaagctgg ccaacggcac caagtacaga ccccccgcca agctgctgaa ggagcggggc     1080

ttcttcgggg ccatcgccgg ctttctcgag ggcggctggg aggggatgat cgctgggtgg     1140

cacgggtaca caagccatgg cgcccacggc gtggccgtgg ccgccgacct caagagcacc     1200

caagaggcca tcaacaagat caccaagaac ctgaacagcc tgagcgagct ggaggtgaag     1260

aacctgcaga gactgagcgg cgccatggac gagctgcaca acgagatcct ggagctggac     1320

gagaaggtgg acgacctgag agccgacacc atcagcagcc aaatcgagct ggccgtcctc     1380

ctgtccaacg agttcatcat caacagcgag gacgagcacc tgctggccca agagagaaag     1440

ctgaagaaga tgctgggccc tagcgccgtg gagatcggga acggctgctt cgagaccaag     1500

cacaagtgca atcagacctg cctggacaga atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgccg ctagcctggg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgagcacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  124
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions  TEV cleavage site - 
       foldon  poly His.

<400>  124
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ctacacaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagagggaa gctgtgcccc aagtgcctga actgcaccga cctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacaag cggctgcttc cccatcatgc acgacagaac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca caacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcggcag ctgccccaac      480

atcaccaacg gcaacggctt cttcgccacc atggcctggg ccgtgcccaa gaacaagacc      540

gccaccaatc ctctgaccat cgaggtgccc tacatctgca ccgagggcga ggatcagatc      600

accgtgtggg gcttccacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacca cccactacgt gagccaaatc      720

ggcggcttcc ccaatcagac cgaggacggc ggcctgcctc agagcggcag aatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaagg tgatcaaggg cagcctgccc      900

ctgatcggcg aggccgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcacgc caaggccatc ggcaactgcc ccatctgggt gaagaccccc     1020

ctgaagctgg ccaacggcac caagtacaga ccccccgcca agctgctgaa ggagcggggc     1080

ttcttcgggg ccatcgccgg ctttctcgag ggcggctggg aggggatgat cgctgggtgg     1140

cacgggtaca caagccatgg cgcccacggc gtggccgtgg ccgccgacct caagagcacc     1200

caagaggcca tcaacaagat caccaagaac ctgaacagcc tgagcgagct ggaggtgaag     1260

aacctgcaga gactgagcgg cgcccccgac gagccccaca acgagatcct ggagctggac     1320

gagaaggtgg acgacctgag agccgacacc atcagcagcc aaatcgagct ggccgtcctc     1380

ctgtccaacg agctgatcat caacagcgag gacgagcacc tgctggccca agagagaaag     1440

ctgaagaaga tgctgggccc tagcgccgtg gagatcggga acggctgctt cgagaccaag     1500

cacaagtgca atcagacctg cctggacaga atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgccg ctagcctggg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgagcacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  125
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions  TEV cleavage site - 
       foldon  poly His.

<400>  125
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ctacacaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagagggaa gctgtgcccc aagtgcctga actgcaccga cctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacaag cggctgcttc cccatcatgc acgacagaac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca caacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcggcag ctgccccaac      480

atcaccaacg gcaacggctt cttcgccacc atggcctggg ccgtgcccaa gaacaagacc      540

gccaccaatc ctctgaccat cgaggtgccc tacatctgca ccgagggcga ggatcagatc      600

accgtgtggg gcttccacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacca cccactacgt gagccaaatc      720

ggcggcttcc ccaatcagac cgaggacggc ggcctgcctc agagcggcag aatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaagg tgatcaaggg cagcctgccc      900

ctgatcggcg aggccgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcacgc caaggccatc ggcaactgcc ccatctgggt gaagaccccc     1020

ctgaagctgg ccaacggcac caagtacaga ccccccgcca agctgctgaa ggagcggggc     1080

ttcttcgggg ccatcgccgg ctttctcgag ggcggctggg aggggatgat cgctgggtgg     1140

cacgggtaca caagccatgg cgcccacggc gtggccgtgg ccgccgacct caagagcacc     1200

caagaggcca tcaacaagat caccaagatg ctgaacagcc tgagcgagct ggaggtgaag     1260

aacctgcaga gactgagcgg cgccatggac gagctgcaca acgagatcct ggagctggac     1320

gagaaggtgg acgacctgag agccgacacc atcagcagcc aaatcgagct ggccgtcctc     1380

ctggtgaacg agctgatcat caacagcgag gacgagcacc tgctggccca agagagaaag     1440

ctgaagaaga tgctgggccc tagcgccgtg gagatcggga acggctgctt cgagaccaag     1500

cacaagtgca atcagacctg cctggacaga atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgccg ctagcctggg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgagcacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  126
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions  TEV cleavage site - 
       foldon  poly His.

<400>  126
atgaaggcca ttatcgtgct cctgatggtg gtgacaagca atgctgacag aatttgcacc       60

gggatcacaa gcagcaacag ccctcacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagaggcaa gctgtgcccc aaatgtctga attgtaccga tctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacatc cggctgcttt cccattatgc acgaccggac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca taacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcgggag ctgccccaac      480

attaccaacg gcaacggctt ctttgccacc atggcctggg ctgtgcccaa gaacaaaacc      540

gctaccaacc ccctgaccat cgaggtgccc tatatttgca ccgaaggcga ggatcagatc      600

acagtctggg gctttcacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacaa cacactacgt gtcccaaatc      720

ggcggcttcc ccaatcagac cgaagatggg ggcctgcctc agagcggccg gatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaaag tgatcaaggg gtccctcccc      900

ctgatcggcg aggctgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcatgc caaggccatc ggcaactgcc ccatttgggt caagaccccc     1020

ctgaagctcg ccaacggcac caaatacaga cctcccgcca agctcctgaa ggagagaggc     1080

tttttcggcg ccatcgccgg cttcctggag gggggctggg aaggcatgat cgccggctgg     1140

cacggctaca catcccacgg cgcccacggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaaaat caccaagaac ctcaacagcc tgtccgagct ggaagtcaag     1260

aacctgcagc ggctgagcgg cgccatggac gaactgcaca acgagatcct cgagctggac     1320

gagaaggtgg acgacctgag agctgacacc atcagcagcc aaattgagct ggctgtgctg     1380

ctgtccaacg aaggcatcat caacagcgag gacatccacc tgctggccca agagagaaaa     1440

ctgaaaaaga tgctgggccc ctccgccgtg gagatcggca acggctgctt cgaaaccaag     1500

cacaaatgca atcaaacatg cctcgaccgg atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgctg cctccctcgg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgtccacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  127
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions  TEV cleavage site - 
       foldon  poly His.

<400>  127
atgaaggcca ttatcgtgct cctgatggtg gtgacaagca atgctgacag aatttgcacc       60

gggatcacaa gcagcaacag ccctcacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagaggcaa gctgtgcccc aaatgtctga attgtaccga tctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacatc cggctgcttt cccattatgc acgaccggac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca taacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcgggag ctgccccaac      480

attaccaacg gcaacggctt ctttgccacc atggcctggg ctgtgcccaa gaacaaaacc      540

gctaccaacc ccctgaccat cgaggtgccc tatatttgca ccgaaggcga ggatcagatc      600

acagtctggg gctttcacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacaa cacactacgt gtcccaaatc      720

ggcggcttcc ccaatcagac cgaagatggg ggcctgcctc agagcggccg gatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaaag tgatcaaggg gtccctcccc      900

ctgatcggcg aggctgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcatgc caaggccatc ggcaactgcc ccatttgggt caagaccccc     1020

ctgaagctcg ccaacggcac caaatacaga cctcccgcca agctcctgaa ggagagaggc     1080

tttttcggcg ccatcgccgg cttcctggag gggggctggg aaggcatgat cgccggctgg     1140

cacggctaca catcccacgg cgcccacggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaaaat caccaagaac ctcaacagcc tgtccgagct ggaagtcaag     1260

aacctgcagc ggctgagcgg cgccatggac gaactgcaca acgagatcct cgagctggac     1320

gagaaggtgg acgacctgag agctgacacc atcagcagcc aaattgagct ggctgtgctg     1380

ctgtccaacg aaggcatcat caacagcgag gacctgcacc tgctggccca agagagaaaa     1440

ctgaaaaaga tgctgggccc ctccgccgtg gagatcggca acggctgctt cgaaaccaag     1500

cacaaatgca atcaaacatg cctcgaccgg atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgctg cctccctcgg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgtccacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  128
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions  TEV cleavage site - 
       foldon  poly His.

<400>  128
atgaaggcca ttatcgtgct cctgatggtg gtgacaagca atgctgacag aatttgcacc       60

gggatcacaa gcagcaacag ccctcacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagaggcaa gctgtgcccc aaatgtctga attgtaccga tctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacatc cggctgcttt cccattatgc acgaccggac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca taacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcgggag ctgccccaac      480

attaccaacg gcaacggctt ctttgccacc atggcctggg ctgtgcccaa gaacaaaacc      540

gctaccaacc ccctgaccat cgaggtgccc tatatttgca ccgaaggcga ggatcagatc      600

acagtctggg gctttcacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacaa cacactacgt gtcccaaatc      720

ggcggcttcc ccaatcagac cgaagatggg ggcctgcctc agagcggccg gatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaaag tgatcaaggg gtccctcccc      900

ctgatcggcg aggctgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcatgc caaggccatc ggcaactgcc ccatttgggt caagaccccc     1020

ctgaagctcg ccaacggcac caaatacaga cctcccgcca agctcctgaa ggagagaggc     1080

tttttcggcg ccatcgccgg cttcctggag gggggctggg aaggcatgat cgccggctgg     1140

cacggctaca catcccacgg cgcccacggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaaaat caccaagaac ctcaacagcc tgtccgagct ggaagtcaag     1260

aacctgcagc ggctgagcgg cgccatggac gaactgcaca acgagatcct cgagctggac     1320

gagaaggtgg acgacctgag agctgacacc atcagcagcc aaattgagct ggctgtgctg     1380

ctgtccaacg aaatcatcat caacagcgag gacatccacc tgctggccca agagagaaaa     1440

ctgaaaaaga tgctgggccc ctccgccgtg gagatcggca acggctgctt cgaaaccaag     1500

cacaaatgca atcaaacatg cctcgaccgg atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgctg cctccctcgg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgtccacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  129
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions  TEV cleavage site - 
       foldon  poly His.

<400>  129
atgaaggcca ttatcgtgct cctgatggtg gtgacaagca atgctgacag aatttgcacc       60

gggatcacaa gcagcaacag ccctcacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagaggcaa gctgtgcccc aaatgtctga attgtaccga tctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacatc cggctgcttt cccattatgc acgaccggac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca taacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcgggag ctgccccaac      480

attaccaacg gcaacggctt ctttgccacc atggcctggg ctgtgcccaa gaacaaaacc      540

gctaccaacc ccctgaccat cgaggtgccc tatatttgca ccgaaggcga ggatcagatc      600

acagtctggg gctttcacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacaa cacactacgt gtcccaaatc      720

ggcggcttcc ccaatcagac cgaagatggg ggcctgcctc agagcggccg gatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaaag tgatcaaggg gtccctcccc      900

ctgatcggcg aggctgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcatgc caaggccatc ggcaactgcc ccatttgggt caagaccccc     1020

ctgaagctcg ccaacggcac caaatacaga cctcccgcca agctcctgaa ggagagaggc     1080

tttttcggcg ccatcgccgg cttcctggag gggggctggg aaggcatgat cgccggctgg     1140

cacggctaca catcccacgg cgcccacggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaaaat caccaagaac ctcaacagcc tgtccgagct ggaagtcaag     1260

aacctgcagc ggctgagcgg cgccatggac gaactgcaca acgagatcct cgagctggac     1320

gagaaggtgg acgacctgag agctgacacc atcagcagcc aaattgagct ggctgtgctg     1380

ctgtccaacg agttcatcat caacagcgag gacatccacc tgctggccca agagagaaaa     1440

ctgaaaaaga tgctgggccc ctccgccgtg gagatcggca acggctgctt cgaaaccaag     1500

cacaaatgca atcaaacatg cctcgaccgg atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgctg cctccctcgg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgtccacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  130
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions  TEV cleavage site - 
       foldon  poly His.

<400>  130
atgaaggcca ttatcgtgct cctgatggtg gtgacaagca atgctgacag aatttgcacc       60

gggatcacaa gcagcaacag ccctcacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagaggcaa gctgtgcccc aaatgtctga attgtaccga tctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacatc cggctgcttt cccattatgc acgaccggac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca taacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcgggag ctgccccaac      480

attaccaacg gcaacggctt ctttgccacc atggcctggg ctgtgcccaa gaacaaaacc      540

gctaccaacc ccctgaccat cgaggtgccc tatatttgca ccgaaggcga ggatcagatc      600

acagtctggg gctttcacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacaa cacactacgt gtcccaaatc      720

ggcggcttcc ccaatcagac cgaagatggg ggcctgcctc agagcggccg gatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaaag tgatcaaggg gtccctcccc      900

ctgatcggcg aggctgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcatgc caaggccatc ggcaactgcc ccatttgggt caagaccccc     1020

ctgaagctcg ccaacggcac caaatacaga cctcccgcca agctcctgaa ggagagaggc     1080

tttttcggcg ccatcgccgg cttcctggag gggggctggg aaggcatgat cgccggctgg     1140

cacggctaca catcccacgg cgcccacggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaaaat caccaagaac ctcaacagcc tgtccgagct ggaagtcaag     1260

aacctgcagc ggctgagcgg cgccatggac gaactgcaca acgagatcct cgagctggac     1320

gagaaggtgg acgacctgag agctgacacc atcagcagcc aaattgagct ggctgtgctg     1380

ctgtccaacg aaatcatcat caacagcgag gacctgcacc tgctggccca agagagaaaa     1440

ctgaaaaaga tgctgggccc ctccgccgtg gagatcggca acggctgctt cgaaaccaag     1500

cacaaatgca atcaaacatg cctcgaccgg atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgctg cctccctcgg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgtccacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  131
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions  TEV cleavage site - 
       foldon  poly His.

<400>  131
atgaaggcca ttatcgtgct cctgatggtg gtgacaagca atgctgacag aatttgcacc       60

gggatcacaa gcagcaacag ccctcacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagaggcaa gctgtgcccc aaatgtctga attgtaccga tctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacatc cggctgcttt cccattatgc acgaccggac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca taacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcgggag ctgccccaac      480

attaccaacg gcaacggctt ctttgccacc atggcctggg ctgtgcccaa gaacaaaacc      540

gctaccaacc ccctgaccat cgaggtgccc tatatttgca ccgaaggcga ggatcagatc      600

acagtctggg gctttcacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacaa cacactacgt gtcccaaatc      720

ggcggcttcc ccaatcagac cgaagatggg ggcctgcctc agagcggccg gatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaaag tgatcaaggg gtccctcccc      900

ctgatcggcg aggctgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcatgc caaggccatc ggcaactgcc ccatttgggt caagaccccc     1020

ctgaagctcg ccaacggcac caaatacaga cctcccgcca agctcctgaa ggagagaggc     1080

tttttcggcg ccatcgccgg cttcctggag gggggctggg aaggcatgat cgccggctgg     1140

cacggctaca catcccacgg cgcccacggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaaaat caccaagaac ctcaacagcc tgtccgagct ggaagtcaag     1260

aacctgcagc ggctgagcgg cgccatggac gaactgcaca acgagatcct cgagctggac     1320

gagaaggtgg acgacctgag agctgacacc atcagcagcc aaattgagct ggctgtgctg     1380

ctgtccaacg agttcatcat caacagcgag gacctgcacc tgctggccca agagagaaaa     1440

ctgaaaaaga tgctgggccc ctccgccgtg gagatcggca acggctgctt cgaaaccaag     1500

cacaaatgca atcaaacatg cctcgaccgg atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgctg cctccctcgg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgtccacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  132
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions  TEV cleavage site - 
       foldon  poly His.

<400>  132
atgaaggcca ttatcgtgct cctgatggtg gtgacaagca atgctgacag aatttgcacc       60

gggatcacaa gcagcaacag ccctcacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagaggcaa gctgtgcccc aaatgtctga attgtaccga tctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacatc cggctgcttt cccattatgc acgaccggac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca taacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcgggag ctgccccaac      480

attaccaacg gcaacggctt ctttgccacc atggcctggg ctgtgcccaa gaacaaaacc      540

gctaccaacc ccctgaccat cgaggtgccc tatatttgca ccgaaggcga ggatcagatc      600

acagtctggg gctttcacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacaa cacactacgt gtcccaaatc      720

ggcggcttcc ccaatcagac cgaagatggg ggcctgcctc agagcggccg gatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaaag tgatcaaggg gtccctcccc      900

ctgatcggcg aggctgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcatgc caaggccatc ggcaactgcc ccatttgggt caagaccccc     1020

ctgaagctcg ccaacggcac caaatacaga cctcccgcca agctcctgaa ggagagaggc     1080

tttttcggcg ccatcgccgg cttcctggag gggggctggg aaggcatgat cgccggctgg     1140

cacggctaca catcccacgg cgcccacggc gtggccgtcg ccgccgacct caagagcacc     1200

caagaggcca tcaacaaaat caccaagatg ctcaacagcc tgtccgagct ggaagtcaag     1260

aacctgcagc ggctgagcgg cgcccccgac gagccccaca acgagatcct cgagctggac     1320

gagaaggtgg acgacctgag agctgacacc atcagcagcc aaattgagct ggctgtgctg     1380

ctggtgaacg aaggcatcat caacagcgag gacgagcacc tgctggccct ggagagaaaa     1440

ctgaaaaaga tgctgggccc ctccgccgtg gagatcggca acggctgctt cgaaaccaag     1500

cacaaatgca atcaaacatg cctcgaccgg atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgctg cctccctcgg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgtccacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  133
<211>  1752
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin 
       ectodomain with amino acid substitutions  TEV cleavage site - 
       foldon  poly His.

<400>  133
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ctacacaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccacaacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga caagagggaa gctgtgcccc aagtgcctga actgcaccga cctggacgtg      240

gccctgggca gacccaagtg caccggcaag atccctagcg ctagagtgag catcctgcac      300

gaggtgagac ccgtgacaag cggctgcttc cccatcatgc acgacagaac caagatcaga      360

cagctgccca acctgctgag aggctacgag cacgtgagac tgagcaccca caacgtgatc      420

aacgccgagg acgcccccgg cagaccctac gagatcggca caagcggcag ctgccccaac      480

atcaccaacg gcaacggctt cttcgccacc atggcctggg ccgtgcccaa gaacaagacc      540

gccaccaatc ctctgaccat cgaggtgccc tacatctgca ccgagggcga ggatcagatc      600

accgtgtggg gcttccacag cgacaacgag acacagatgg ccaagctgta cggcgacagc      660

aagcctcaga agttcacaag cagcgccaac ggcgtgacca cccactacgt gagccaaatc      720

ggcggcttcc ccaatcagac cgaggacggc ggcctgcctc agagcggcag aatcgtggtg      780

gactacatgg tgcaaaagag cggcaagacc ggcaccatca cctatcagag aggcatcctg      840

ctgcctcaga aggtgtggtg cgctagcggc agaagcaagg tgatcaaggg cagcctgccc      900

ctgatcggcg aggccgactg cctgcacgag aagtacggcg gcctgaacaa gagcaagccc      960

tactacaccg gcgagcacgc caaggccatc ggcaactgcc ccatctgggt gaagaccccc     1020

ctgaagctgg ccaacggcac caagtacaga ccccccgcca agctgctgaa ggagcggggc     1080

ttcttcgggg ccatcgccgg ctttctcgag ggcggctggg aggggatgat cgctgggtgg     1140

cacgggtaca caagccatgg cgcccacggc gtggccgtgg ccgccgacct caagagcacc     1200

caagaggcca tcaacaagat caccaagatg ctgaacagcc tgagcgagct ggaggtgaag     1260

aacctgcaga gactgagcgg cgcccccgac gagccccaca acgagatcct ggagctggac     1320

gagaaggtgg acgacctgag agccgacacc atcagcagcc aaatcgagct ggccgtcctc     1380

ctggtgaacg agctgatcat caacagcgag gacgagcacc tgctggccca agagagaaag     1440

ctgaagaaga tgctgggccc tagcgccgtg gagatcggga acggctgctt cgagaccaag     1500

cacaagtgca atcagacctg cctggacaga atcgccgccg gcaccttcga cgccggcgag     1560

ttcagcctgc ccaccttcga cagcctgaac atcaccgccg ctagcctggg cagcgagaac     1620

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc     1680

tacgtgagaa aggacggcga gtgggtgctg ctgagcacct tcctgggcca ccatcaccat     1740

caccactgat ga                                                         1752


<210>  134
<211>  825
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  134
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gggcagcggc ctgaagctgg ccaacggcac caagtacaga      180

ccccccgcca agctgctgaa ggagagaggg ttcttcggcg ccatcgccgg cttcctggag      240

ggcggctggg aaggcatgat cgctgggtgg cacggctaca caagccacgg cgctcatggc      300

gtggccgtcg ccgccgacct caagagcacc caagaggcca tcaacaagat caccaagaac      360

ctgaacagcc tgagcgagct ggaggtgaag aacggcagcg gcagcgacct gagagccgac      420

accatcagca gccaaatcga gctggccgtg ctgctgagca acgaggtgat catcaacagc      480

gaggacgagc acctgctggc cctggagaga aagctgaaga agatgctggg ccctagcgcc      540

gtggagatcg ggaacggctg cttcgagacc aagcacaagt gcaatcagac ctgcctggac      600

agaatcgccg ccggcacctt cgacgccggc gagttcagcc tgcccacctt cgacagcctg      660

aacatcaccg ccgctagcct gggcagcgag aacctgtact tccaaggcgg cagcaagggc      720

tacatccccg aggcccctag agacggccaa gcctacgtga gaaaggacgg cgagtgggtg      780

ctgctgagca ccttcctggg ccaccatcac catcaccact gatga                      825


<210>  135
<211>  825
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  135
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gggcagcggc ctgaagctgg ccaacggcac caagtacaga      180

ccccccgcca agctgctgaa ggagagaggg ttcttcggcg ccatcgccgg cttcctggag      240

ggcggctggg aaggcatgat cgctgggtgg cacggctaca caagccacgg cgctcatggc      300

gtggccgtcg ccgccgacct caagagcacc caagaggcca tcaacaagat caccaagaac      360

ctgaacagcc tgagcgagct ggaggtgaag aacggcagcg gcagcgacct gagagccgac      420

accatcagca gccaaatcga gctggccgtg ctgctgagca acgagttcat catcaacagc      480

gaggacgagc acctgctggc ccaagagaga aagctgaaga agatgctggg ccctagcgcc      540

gtggagatcg ggaacggctg cttcgagacc aagcacaagt gcaatcagac ctgcctggac      600

agaatcgccg ccggcacctt cgacgccggc gagttcagcc tgcccacctt cgacagcctg      660

aacatcaccg ccgctagcct gggcagcgag aacctgtact tccaaggcgg cagcaagggc      720

tacatccccg aggcccctag agacggccaa gcctacgtga gaaaggacgg cgagtgggtg      780

ctgctgagca ccttcctggg ccaccatcac catcaccact gatga                      825


<210>  136
<211>  825
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  136
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gggcagcggc ctgaagctgg ccaacggcac caagtacaga      180

ccccccgcca agctgctgaa ggagagaggg ttcttcggcg ccatcgccgg cttcctggag      240

ggcggctggg aaggcatgat cgctgggtgg cacggctaca caagccacgg cgctcatggc      300

gtggccgtcg ccgccgacct caagagcacc caagaggcca tcaacaagat caccaagatg      360

ctgaacagcc tgagcgagct ggaggtgaag aacggcagcg gcagcgacct gagagccgac      420

accatcagca gccaaatcga gctggccgtg ctgctggtga acgaggtgat catcaacagc      480

gaggacgagc acctgctggc cctggagaga aagctgaaga agatgctggg ccctagcgcc      540

gtggagatcg ggaacggctg cttcgagacc aagcacaagt gcaatcagac ctgcctggac      600

agaatcgccg ccggcacctt cgacgccggc gagttcagcc tgcccacctt cgacagcctg      660

aacatcaccg ccgctagcct gggcagcgag aacctgtact tccaaggcgg cagcaagggc      720

tacatccccg aggcccctag agacggccaa gcctacgtga gaaaggacgg cgagtgggtg      780

ctgctgagca ccttcctggg ccaccatcac catcaccact gatga                      825


<210>  137
<211>  825
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  137
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gggcagcggc ctgaagctgg ccaacggcac caagtacaga      180

ccccccgcca agctgctgaa ggagagaggg ttcttcggcg ccatcgccgg cttcctggag      240

ggcggctggg aaggcatgat cgctgggtgg cacggctaca caagccacgg cgctcatggc      300

gtggccgtcg ccgccgacct caagagcacc caagaggcca tcaacaagat caccaagatg      360

ctgaacagcc tgagcgagct ggaggtgaag aacggcagcg gcagcgacct gagagccgac      420

accatcagca gccaaatcga gctggccgtg ctgctggtga acgagttcat catcaacagc      480

gaggacgagc acctgctggc ccaagagaga aagctgaaga agatgctggg ccctagcgcc      540

gtggagatcg ggaacggctg cttcgagacc aagcacaagt gcaatcagac ctgcctggac      600

agaatcgccg ccggcacctt cgacgccggc gagttcagcc tgcccacctt cgacagcctg      660

aacatcaccg ccgctagcct gggcagcgag aacctgtact tccaaggcgg cagcaagggc      720

tacatccccg aggcccctag agacggccaa gcctacgtga gaaaggacgg cgagtgggtg      780

ctgctgagca ccttcctggg ccaccatcac catcaccact gatga                      825


<210>  138
<211>  795
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  138
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gggcagcctg aagctggcca acggcaccaa gtacagaccc      180

cccgccaagc tgctgaagga gagagggttc ttcggcgcca tcgccggctt cctggagggc      240

ggctgggaag gcatgatcgc tgggtggcac ggctacacaa gccacggcgc tcatggcgtg      300

gccgtcgccg ccgacctcaa gagcacccaa gaggccatca acaagatcac caagatgctg      360

aacagcctga gcgagctgga gggcagcggc agcggcagca gccaaatcga gctggccgtg      420

ctgctggtga acgagttcat catcaacagc gaggacgagc acctgctggc ccaagagaga      480

aagctgaaga agatgctggg ccctagcgcc gtggagatcg ggaacggctg cttcgagacc      540

aagcacaagt gcaatcagac ctgcctggac agaatcgccg ccggcacctt cgacgccggc      600

gagttcagcc tgcccacctt cgacagcctg aacatcaccg ccgctagcct gggcagcgag      660

aacctgtact tccaaggcgg cagcaagggc tacatccccg aggcccctag agacggccaa      720

gcctacgtga gaaaggacgg cgagtgggtg ctgctgagca ccttcctggg ccaccatcac      780

catcaccact gatga                                                       795


<210>  139
<211>  801
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  139
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gggcagcggc ctgaagctgg ccaacggcac caagtacaga      180

ccccccgcca agctgctgaa ggagagaggg ttcttcggcg ccatcgccgg cttcctggag      240

ggcggctggg aaggcatgat cgctgggtgg cacggctaca caagccacgg cgctcatggc      300

gtggccgtcg ccgccgacct caagagcacc caagaggcca tcaacaagat caccaagatg      360

ctgaacagcc tgagcgagct ggagggcagc ggcggcagcg gcagcagcca aatcgagctg      420

gccgtgctgc tggtgaacga gttcatcatc aacagcgagg acgagcacct gctggccctg      480

gagagaaagc tgaagaagat gctgggccct agcgccgtgg agatcgggaa cggctgcttc      540

gagaccaagc acaagtgcaa tcagacctgc ctggacagaa tcgccgccgg caccttcgac      600

gccggcgagt tcagcctgcc caccttcgac agcctgaaca tcaccgccgc tagcctgggc      660

agcgagaacc tgtacttcca aggcggcagc aagggctaca tccccgaggc ccctagagac      720

ggccaagcct acgtgagaaa ggacggcgag tgggtgctgc tgagcacctt cctgggccac      780

catcaccatc accactgatg a                                                801


<210>  140
<211>  801
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  140
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gggcagcggc ctgaagctgg ccaacggcac caagtacaga      180

ccccccgcca agctgctgaa ggagagaggg ttcttcggcg ccatcgccgg cttcctggag      240

ggcggctggg aaggcatgat cgctgggtgg cacggctaca caagccacgg cgctcatggc      300

gtggccgtcg ccgccgacct caagagcacc caagaggcca tcaacaagat caccaagatg      360

ctgaacagcc tgagcgagct ggagggcagc ggcggcagcg gcagcagcca aatcgagctg      420

gccgtgctgc tggtgaacga gttcatcatc aacagcgagg acgagcacct gctggcccaa      480

gagagaaagc tgaagaagat gctgggccct agcgccgtgg agatcgggaa cggctgcttc      540

gagaccaagc acaagtgcaa tcagacctgc ctggacagaa tcgccgccgg caccttcgac      600

gccggcgagt tcagcctgcc caccttcgac agcctgaaca tcaccgccgc tagcctgggc      660

agcgagaacc tgtacttcca aggcggcagc aagggctaca tccccgaggc ccctagagac      720

ggccaagcct acgtgagaaa ggacggcgag tgggtgctgc tgagcacctt cctgggccac      780

catcaccatc accactgatg a                                                801


<210>  141
<211>  825
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  141
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gggcagcggc ctgaagctgg ccaacggcac caagtacaga      180

ccccccgcca agctgctgaa ggagagaggg ttcttcggcg ccatcgccgg cttcctggag      240

ggcggctggg aaggcatgat cgctgggtgg cacggctaca caagccacgg cgctcatggc      300

gtggccgtcg ccgccgacct caagagcacc caagaggcca tcaacaagat caccaagaac      360

ctgaacagcc tgagcgagct ggaggtgaag aacggcagcg gcagcgacag cagagccgac      420

gtgatcagca gccaaatcga gctggccgtg ctgctgagca acgagggcat catcaacagc      480

gaggacgagc acctgctggc cctggagaga aagctgaaga agatgctggg ccctagcgcc      540

gtggagatcg ggaacggctg cttcgagacc aagcacaagt gcaatcagac ctgcctggac      600

agaatcgccg ccggcacctt cgacgccggc gagttcagcc tgcccacctt cgacagcctg      660

aacatcaccg ccgctagcct gggcagcgag aacctgtact tccaaggcgg cagcaagggc      720

tacatccccg aggcccctag agacggccaa gcctacgtga gaaaggacgg cgagtgggtg      780

ctgctgagca ccttcctggg ccaccatcac catcaccact gatga                      825


<210>  142
<211>  825
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  142
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gggcagcggc ctgaagctgg ccaacggcac caagtacaga      180

ccccccgcca agctgctgaa ggagagaggg ttcttcggcg ccatcgccgg cttcctggag      240

ggcggctggg aaggcatgat cgctgggtgg cacggctaca caagccacgg cgctcatggc      300

gtggccgtcg ccgccgacct caagagcacc caagaggcca tcaacaagat caccaagaac      360

ctgaacagcc tgagcgagct ggagagcaag aacggcagcg gcagcgacca gagagccgac      420

gtgaacagca gccaaatcga gctggccgtg ctgctgagca acgagggcat catcaacagc      480

gaggacgagc acctgctggc cctggagaga aagctgaaga agatgctggg ccctagcgcc      540

gtggagatcg ggaacggctg cttcgagacc aagcacaagt gcaatcagac ctgcctggac      600

agaatcgccg ccggcacctt cgacgccggc gagttcagcc tgcccacctt cgacagcctg      660

aacatcaccg ccgctagcct gggcagcgag aacctgtact tccaaggcgg cagcaagggc      720

tacatccccg aggcccctag agacggccaa gcctacgtga gaaaggacgg cgagtgggtg      780

ctgctgagca ccttcctggg ccaccatcac catcaccact gatga                      825


<210>  143
<211>  825
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  143
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gggcagcggc ctgaagctgg ccaacggcac caagtacaga      180

ccccccgcca agctgctgaa ggagagaggg ttcttcggcg ccatcgccgg cttcctggag      240

ggcggctggg aaggcatgat cgctgggtgg cacggctaca caagccacgg cgctcatggc      300

gtggccgtcg ccgccgacct caagagcacc caagaggcca tcaacaagat caccaagaac      360

ctgaacagcc tgagcgagct ggagagcaag aacggcagcg gcagcgacca gagagccgac      420

gtgaacagca gccaaatcga gctggccgtg ctgctgagca acgagctgat catcaacagc      480

gaggacgagc acctgctggc cctggagaga aagctgaaga agatgctggg ccctagcgcc      540

gtggagatcg ggaacggctg cttcgagacc aagcacaagt gcaatcagac ctgcctggac      600

agaatcgccg ccggcacctt cgacgccggc gagttcagcc tgcccacctt cgacagcctg      660

aacatcaccg ccgctagcct gggcagcgag aacctgtact tccaaggcgg cagcaagggc      720

tacatccccg aggcccctag agacggccaa gcctacgtga gaaaggacgg cgagtgggtg      780

ctgctgagca ccttcctggg ccaccatcac catcaccact gatga                      825


<210>  144
<211>  798
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem  
       TEV cleavage site - foldon  poly His.

<400>  144
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gggcagcggc ctgaagctgg ccaacggcac caagtacaga      180

ccccccgcca agctgctgaa ggagagaggg ttcttcggcg ccatcgccgg cttcctggag      240

ggcggctggg aaggcatgat cgctgggtgg cacggctaca caagccacgg cgctcatggc      300

gtggccgtcg ccgccgacct caagagcacc caagaggcca tcaacaagat caccaagaac      360

ctgaacgacg tggccaacaa ggtgagcaag gccggcagca gcagccaaat cgagctggcc      420

gtgctgctga gcaacgaggg catcatcaac agcgaggacg agcacctgct ggccctggag      480

agaaagctga agaagatgct gggccctagc gccgtggaga tcgggaacgg ctgcttcgag      540

accaagcaca agtgcaatca gacctgcctg gacagaatcg ccgccggcac cttcgacgcc      600

ggcgagttca gcctgcccac cttcgacagc ctgaacatca ccgccgctag cctgggcagc      660

gagaacctgt acttccaagg cggcagcaag ggctacatcc ccgaggcccc tagagacggc      720

caagcctacg tgagaaagga cggcgagtgg gtgctgctga gcaccttcct gggccaccat      780

caccatcacc actgatga                                                    798


<210>  145
<211>  798
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem  
       TEV cleavage site - foldon  poly His.

<400>  145
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gggcagcggc ctgaagctgg ccaacggcac caagtacaga      180

ccccccgcca agctgctgaa ggagagaggg ttcttcggcg ccatcgccgg cttcctggag      240

ggcggctggg aaggcatgat cgctgggtgg cacggctaca caagccacgg cgctcatggc      300

gtggccgtcg ccgccgacct caagagcacc caagaggcca tcaacaagat caccaagaac      360

ctgaacgacg tggccaacaa ggtgagcaag gccggcggca gcagccaaat cgagctggcc      420

gtgctgctga gcaacgaggg catcatcaac agcgaggacg agcacctgct ggccctggag      480

agaaagctga agaagatgct gggccctagc gccgtggaga tcgggaacgg ctgcttcgag      540

accaagcaca agtgcaatca gacctgcctg gacagaatcg ccgccggcac cttcgacgcc      600

ggcgagttca gcctgcccac cttcgacagc ctgaacatca ccgccgctag cctgggcagc      660

gagaacctgt acttccaagg cggcagcaag ggctacatcc ccgaggcccc tagagacggc      720

caagcctacg tgagaaagga cggcgagtgg gtgctgctga gcaccttcct gggccaccat      780

caccatcacc actgatga                                                    798


<210>  146
<211>  795
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  146
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagacag ccacccaagg cgaggtcaac      120

gtcaccggcg tcattcccgc tagcaccggc aagctggcca acggcaccaa gtacagaccc      180

cccgccaagc tgctgaagga gagaggcttc ttcggcgcca ttgccggctt cctggagggg      240

ggctgggagg gcatgatcgc cgggtggcat gggtacacaa gccatggcgc ccatggcgtg      300

gccgtcgccg ccgacctcaa gagcacccaa gaggccatca acaagatcac caagatgctg      360

aacagcctga gcaagatcct gaccggcgac tacacaagca gccaaatcga gctggccgtg      420

ctgctggtga acgagttcat catcaacagc gaggacgagc acctgctggc ccaagagaga      480

aagctgaaga agatgctggg ccctagcgcc gtggagatcg ggaacggctg cttcgagacc      540

aagcacaagt gcaatcagac ctgcctggac agaatcgccg ccggcacctt cgacgccggc      600

gagttcagcc tgcccacctt cgacagcctg aacatcaccg ccgctagcct gggcagcgag      660

aacctgtact tccaaggcgg cagcaagggc tacatccccg aggcccctag agacggccaa      720

gcctacgtga gaaaggacgg cgagtgggtg ctgctgagca ccttcctggg ccaccatcac      780

catcaccact gatga                                                       795


<210>  147
<211>  801
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  147
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccat ccccggcacc ggcaccaagc tggccaacgg caccaagtac      180

agaccccccg ccaagctgct gaaggagaga ggcttcttcg gcgccatcgc cgggttcctc      240

gaagggggct gggagggcat gatcgctggc tggcacggct acacaagcca cggcgcccat      300

ggcgtcgctg tcgccgccga cctcaagagc acccaagagg ccatcaacaa gatcaccaag      360

atgctgaaca gcctgagcaa gatcctgacc ggcgactaca caagcagcca aatcgagctg      420

gccgtgctgc tggtgaacga gttcatcatc aacagcgagg acgagcacct gctggcccaa      480

gagagaaagc tgaagaagat gctgggccct agcgccgtgg agatcgggaa cggctgcttc      540

gagaccaagc acaagtgcaa tcagacctgc ctggacagaa tcgccgccgg caccttcgac      600

gccggcgagt tcagcctgcc caccttcgac agcctgaaca tcaccgccgc tagcctgggc      660

agcgagaacc tgtacttcca aggcggcagc aagggctaca tccccgaggc ccctagagac      720

ggccaagcct acgtgagaaa ggacggcgag tgggtgctgc tgagcacctt cctgggccac      780

catcaccatc accactgatg a                                                801


<210>  148
<211>  798
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  148
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaagtcaat      120

gtcaccgggg tcattcccct gcccacaagc aaactggcca acggcaccaa gtacagaccc      180

cccgccaagc tgctgaaaga gcggggcttc ttcggcgcca ttgccggctt cctggagggg      240

ggctgggaag gcatgattgc tggctggcat ggctacacaa gccacggcgc ccatggcgtc      300

gctgtggccg ccgacctcaa gagcacccaa gaggccatca acaagatcac caagatgctg      360

aacagcctga gcgccttcta cgaggccttc cccggcgcca caagccaaat cgagctggcc      420

gtgctgctgg tgaacgagtt catcatcaac agcgaggacg agcacctgct ggcccaagag      480

agaaagctga agaagatgct gggccctagc gccgtggaga tcgggaacgg ctgcttcgag      540

accaagcaca agtgcaatca gacctgcctg gacagaatcg ccgccggcac cttcgacgcc      600

ggcgagttca gcctgcccac cttcgacagc ctgaacatca ccgccgctag cctgggcagc      660

gagaacctgt acttccaagg cggcagcaag ggctacatcc ccgaggcccc tagagacggc      720

caagcctacg tgagaaagga cggcgagtgg gtgctgctga gcaccttcct gggccaccat      780

caccatcacc actgatga                                                    798


<210>  149
<211>  801
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  149
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaagtcaat      120

gtcaccgggg tcattcccta cgccgacggc ggcaaactgg ccaacggcac caagtacaga      180

ccccccgcca agctgctgaa agagcggggc ttcttcggcg ccattgccgg cttcctggag      240

gggggctggg aaggcatgat tgctggctgg catggctaca caagccacgg cgcccatggc      300

gtcgctgtgg ccgccgacct caagagcacc caagaggcca tcaacaagat caccaagatg      360

ctgaacagcc tgagcgcctt ctacgaggcc ttccccggcg ccacaagcca aatcgagctg      420

gccgtgctgc tggtgaacga gttcatcatc aacagcgagg acgagcacct gctggcccaa      480

gagagaaagc tgaagaagat gctgggccct agcgccgtgg agatcgggaa cggctgcttc      540

gagaccaagc acaagtgcaa tcagacctgc ctggacagaa tcgccgccgg caccttcgac      600

gccggcgagt tcagcctgcc caccttcgac agcctgaaca tcaccgccgc tagcctgggc      660

agcgagaacc tgtacttcca aggcggcagc aagggctaca tccccgaggc ccctagagac      720

ggccaagcct acgtgagaaa ggacggcgag tgggtgctgc tgagcacctt cctgggccac      780

catcaccatc accactgatg a                                                801


<210>  150
<211>  804
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  150
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaagtcaat      120

gtcaccgggg tcattcccct gaagggcacc gggggcaaac tggccaacgg caccaagtac      180

agaccccccg ccaagctgct gaaagagcgg ggcttcttcg gcgccattgc cggcttcctg      240

gaggggggct gggaaggcat gattgctggc tggcatggct acacaagcca cggcgcccat      300

ggcgtcgctg tggccgccga cctcaagagc acccaagagg ccatcaacaa gatcaccaag      360

atgctgaaca gcctgagcgc cttctacgag gccttccccg gcgccacaag ccaaatcgag      420

ctggccgtgc tgctggtgaa cgagttcatc atcaacagcg aggacgagca cctgctggcc      480

caagagagaa agctgaagaa gatgctgggc cctagcgccg tggagatcgg gaacggctgc      540

ttcgagacca agcacaagtg caatcagacc tgcctggaca gaatcgccgc cggcaccttc      600

gacgccggcg agttcagcct gcccaccttc gacagcctga acatcaccgc cgctagcctg      660

ggcagcgaga acctgtactt ccaaggcggc agcaagggct acatccccga ggcccctaga      720

gacggccaag cctacgtgag aaaggacggc gagtgggtgc tgctgagcac cttcctgggc      780

caccatcacc atcaccactg atga                                             804


<210>  151
<211>  801
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  151
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccca gagcggcggc aagctggcca acggcaccaa gtacagaccc      180

cccgccaagc tgctgaagga gagaggcttc ttcggcgcca tcgccgggtt cctcgaaggg      240

ggctgggagg gcatgatcgc tgggtggcac ggctacacat cccacggcgc ccatggcgtc      300

gctgtggccg ccgacctcaa gagcacccaa gaggccatca acaagatcac caagatgctg      360

aacagcctga gcgccaccct ggatagaatc ccctccctga aggagagcca aatcgagctg      420

gccgtgctgc tggtgaacga gttcatcatc aacagcgagg acgagcacct gctggcccaa      480

gagagaaagc tgaagaagat gctgggccct agcgccgtgg agatcgggaa cggctgcttc      540

gagaccaagc acaagtgcaa tcagacctgc ctcgatagaa tcgccgctgg caccttcgac      600

gccggcgagt tcagcctgcc caccttcgac agcctgaaca tcaccgccgc tagcctgggc      660

agcgagaacc tgtacttcca aggcggcagc aagggctaca tccccgaggc ccctagagac      720

ggccaagcct acgtgagaaa ggacggcgag tgggtgctgc tgagcacctt cctgggccac      780

catcaccatc accactgatg a                                                801


<210>  152
<211>  804
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  152
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccac ccctagcggc agcaagctgg ccaacggcac caagtacaga      180

ccccccgcca agctgctgaa ggagagaggc ttcttcggcg ccatcgccgg gttcctcgaa      240

gggggctggg agggcatgat cgctggctgg cacggctaca caagccacgg cgcccatggc      300

gtcgctgtcg ccgccgacct caagagcacc caagaggcca tcaacaagat caccaagatg      360

ctgaacagcc tgagcgccac cctggacgag atccctagcc tgaaggagag ccaaatcgag      420

ctggccgtgc tgctggtgaa cgagttcatc atcaacagcg aggacgagca cctgctggcc      480

caagagagaa agctgaagaa gatgctgggc cctagcgccg tggagatcgg gaacggctgc      540

ttcgagacca agcacaagtg caatcagacc tgcctggaca gaatcgccgc cggcaccttc      600

gacgccggcg agttcagcct gcccaccttc gacagcctga acatcaccgc cgctagcctg      660

ggcagcgaga acctgtactt ccaaggcggc agcaagggct acatccccga ggcccctaga      720

gacggccaag cctacgtgag aaaggacggc gagtgggtgc tgctgagcac cttcctgggc      780

caccatcacc atcaccactg atga                                             804


<210>  153
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  153
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccctag cacctacgcc gccatcggca acgccctgaa gctggccaac      180

ggcaccaagt acagaccccc cgccaagctg ctgaaggaga gaggcttctt cggcgccatt      240

gccggcttcc tggagggggg ctgggagggg atgatcgccg gctggcatgg gtacacaagc      300

cacggcgctc atggcgtggc tgtggccgcc gacctcaaga gcacccaaga ggccatcaac      360

aagatcacca agatgctgaa cagcctgagc aacgccatga gcaagctggc tcagcagttc      420

accgatcagc ccacccctag cgctgccgac accatcagca gccaaatcga gctggccgtg      480

ctgctggtga acgagttcat catcaacagc gaggacgagc acctgctggc ccaagagaga      540

aagctgaaga agatgctggg ccctagcgcc gtggagatcg ggaacggctg cttcgagacc      600

aagcacaagt gcaatcagac ctgcctggac agaatcgccg ccggcacctt cgacgccggc      660

gagttcagcc tgcccacctt cgacagcctg aacatcaccg ccgctagcct gggcagcgag      720

aacctgtact tccaaggcgg cagcaagggc tacatccccg aggcccctag agacggccaa      780

gcctacgtga gaaaggacgg cgagtgggtg ctgctgagca ccttcctggg ccaccatcac      840

catcaccact gatga                                                       855


<210>  154
<211>  846
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  154
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccat cgccggcccc caaggcagcg tgaagctggc caacggcacc      180

aagtacagac cccccgccaa gctgctgaag gagcggggct tcttcggcgc catcgccggc      240

ttcctggagg gcggctggga gggcatgatt gccggctggc atggctacac aagccacggg      300

gcccatgggg tggctgtcgc cgccgacctc aagagcaccc aagaggccat caacaagatc      360

accaagatgc tgaacagcct gagcgagacc gtggccaaat gggagaagca actcgccgcc      420

ggcgacccta gcgccgccga caccatcagc agccaaatcg agctggccgt gctgctggtg      480

aacgagttca tcatcaacag cgaggacgag cacctgctgg cccaagagag aaagctgaag      540

aagatgctgg gccctagcgc cgtggagatc gggaacggct gcttcgagac caagcacaag      600

tgcaatcaga cctgcctgga cagaatcgcc gccggcacct tcgacgccgg cgagttcagc      660

ctgcccacct tcgacagcct gaacatcacc gccgctagcc tgggcagcga gaacctgtac      720

ttccaaggcg gcagcaaggg ctacatcccc gaggccccta gagacggcca agcctacgtg      780

agaaaggacg gcgagtgggt gctgctgagc accttcctgg gccaccatca ccatcaccac      840

tgatga                                                                 846


<210>  155
<211>  849
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  155
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccct gaccgtgaac ggcgaggacg tgggcaagct ggccaacggc      180

accaagtaca gaccccccgc caagctgctg aaggagcggg gcttcttcgg cgccatcgcc      240

ggcttcctgg agggcggctg ggagggcatg attgccggct ggcatggcta cacaagccac      300

ggggcccatg gggtggctgt cgccgccgac ctcaagagca cccaagaggc catcaacaag      360

atcaccaaga tgctgaacag cctgagcgag accgtggcca aatgggagaa gcaactcgcc      420

gccggcgacc ctagcgccgc cgacaccatc agcagccaaa tcgagctggc cgtgctgctg      480

gtgaacgagt tcatcatcaa cagcgaggac gagcacctgc tggcccaaga gagaaagctg      540

aagaagatgc tgggccctag cgccgtggag atcgggaacg gctgcttcga gaccaagcac      600

aagtgcaatc agacctgcct ggacagaatc gccgccggca ccttcgacgc cggcgagttc      660

agcctgccca ccttcgacag cctgaacatc accgccgcta gcctgggcag cgagaacctg      720

tacttccaag gcggcagcaa gggctacatc cccgaggccc ctagagacgg ccaagcctac      780

gtgagaaagg acggcgagtg ggtgctgctg agcaccttcc tgggccacca tcaccatcac      840

cactgatga                                                              849


<210>  156
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  156
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccccgt ggccatcccc aacacaagct acgtggtgaa gctggccaac      180

ggcaccaagt acagaccccc cgccaagctg ctgaaggagc ggggcttctt cggcgccatc      240

gccggcttcc tggagggcgg ctgggagggc atgattgccg gctggcatgg ctacacaagc      300

cacggggccc atggggtggc tgtcgccgcc gacctcaaga gcacccaaga ggccatcaac      360

aagatcacca agatgctgaa cagcctgagc gagaccgtgg ccaaatggga gaagcaactc      420

gccgccggcg accctagcgc cgccgacacc atcagcagcc aaatcgagct ggccgtgctg      480

ctggtgaacg agttcatcat caacagcgag gacgagcacc tgctggccca agagagaaag      540

ctgaagaaga tgctgggccc tagcgccgtg gagatcggga acggctgctt cgagaccaag      600

cacaagtgca atcagacctg cctggacaga atcgccgccg gcaccttcga cgccggcgag      660

ttcagcctgc ccaccttcga cagcctgaac atcaccgccg ctagcctggg cagcgagaac      720

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc      780

tacgtgagaa aggacggcga gtgggtgctg ctgagcacct tcctgggcca ccatcaccat      840

caccactgat ga                                                          852


<210>  157
<211>  849
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  157
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatcccttt cgagaacaac ctgttcagag ccaagctggc caacggcacc      180

aagtacagac cccccgccaa gctgctgaag gagagaggct tcttcggcgc cattgccggc      240

ttcctggagg ggggctggga ggggatgatc gccggctggc atgggtacac aagccacggc      300

gctcatggcg tggctgtggc cgccgacctc aagagcaccc aagaggccat caacaagatc      360

accaagatgc tgaacagcct gagcaacgcc atgagcaagc tggctcagca gttcaccgat      420

cagcccaccc ctagcgctgc cgacaccatc agcagccaaa tcgagctggc cgtgctgctg      480

gtgaacgagt tcatcatcaa cagcgaggac gagcacctgc tggcccaaga gagaaagctg      540

aagaagatgc tgggccctag cgccgtggag atcgggaacg gctgcttcga gaccaagcac      600

aagtgcaatc agacctgcct ggacagaatc gccgccggca ccttcgacgc cggcgagttc      660

agcctgccca ccttcgacag cctgaacatc accgccgcta gcctgggcag cgagaacctg      720

tacttccaag gcggcagcaa gggctacatc cccgaggccc ctagagacgg ccaagcctac      780

gtgagaaagg acggcgagtg ggtgctgctg agcaccttcc tgggccacca tcaccatcac      840

cactgatga                                                              849


<210>  158
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  158
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccctgt ggccttcaac aacgacaaca atcagaagct ggccaacggc      180

accaagtaca gaccccccgc caagctgctg aaggagagag gcttcttcgg cgccattgcc      240

ggcttcctgg aggggggctg ggaggggatg atcgccggct ggcatgggta cacaagccac      300

ggcgctcatg gcgtggctgt ggccgccgac ctcaagagca cccaagaggc catcaacaag      360

atcaccaaga tgctgaacag cctgagcaac gccatgagca agctggctca gcagttcacc      420

gatcagccca cccctagcgc tgccgacacc atcagcagcc aaatcgagct ggccgtgctg      480

ctggtgaacg agttcatcat caacagcgag gacgagcacc tgctggccca agagagaaag      540

ctgaagaaga tgctgggccc tagcgccgtg gagatcggga acggctgctt cgagaccaag      600

cacaagtgca atcagacctg cctggacaga atcgccgccg gcaccttcga cgccggcgag      660

ttcagcctgc ccaccttcga cagcctgaac atcaccgccg ctagcctggg cagcgagaac      720

ctgtacttcc aaggcggcag caagggctac atccccgagg cccctagaga cggccaagcc      780

tacgtgagaa aggacggcga gtgggtgctg ctgagcacct tcctgggcca ccatcaccat      840

caccactgat ga                                                          852


<210>  159
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence coding for influenza B haemagglutinin stem 
       with amino acid substitutions  TEV cleavage site - foldon  poly
       His.

<400>  159
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgacag aatctgcacc       60

ggcatcacaa gcagcaacag cccccacgtg gtgaagaccg ccacccaagg cgaggtgaac      120

gtgaccggcg tgatccctag cacctacgcc gccatcggca acgccctgaa gctggccaac      180

ggcaccaagt acagaccccc cgccaagctg ctgaaggaga gaggcttctt cggcgccatt      240

gccggcttcc tggagggggg ctgggagggg atgatcgccg gctggcatgg gtacacaagc      300

cacggcgctc atggcgtggc tgtggccgcc gacctcaaga gcacccaaga ggccatcaac      360

aagatcacca agatgctgaa cagcctgagc aacgccatga gcaagctggc tcagcagttc      420

accgatcagc ccacccctag cgctgccgac accatcagca gccaaatcga gctggccgtg      480

ctgctggtga acgagttcat catcaacagc gaggacgagc acctgctggc ccaagagaga      540

aagctgaaga agatgctggg ccctagcgcc gtggagatcg ggaacggctg cttcgagacc      600

aagcacaagt gcaatcagac ctgcctggac agaatcgccg ccggcacctt cgacgccggc      660

gagttcagcc tgcccacctt cgacagcctg aacatcaccg ccgctagcct gggcagcgag      720

aacctgtact tccaaggcgg cagcaagggc tacatccccg aggcccctag agacggccaa      780

gcctacgtga gaaaggacgg cgagtgggtg ctgctgagca ccttcctggg ccaccatcac      840

catcaccact gatga                                                       855


<210>  160
<211>  262
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem construct with amino 
       acid substitutions Flu075 - membrane anchoring sequence

<400>  160

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys Leu 
    50                  55                  60                  


Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly 
65                  70                  75                  80  


Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly 
                85                  90                  95      


Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala 
            100                 105                 110         


Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Glu Leu Glu Gly 
        115                 120                 125             


Ser Gly Ser Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Val Asn Glu 
    130                 135                 140                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
145                 150                 155                 160 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                165                 170                 175     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            180                 185                 190         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        195                 200                 205             


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
    210                 215                 220                 


Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr 
225                 230                 235                 240 


Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg Asp Asn Val 
                245                 250                 255     


Ser Cys Ser Ile Cys Leu 
            260         


<210>  161
<211>  382
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem construct with amino 
       acid substitutions Flu075 - SGG linker - Helicobacter pylori 
       ferritin

<400>  161

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys Leu 
    50                  55                  60                  


Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly 
65                  70                  75                  80  


Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly 
                85                  90                  95      


Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala 
            100                 105                 110         


Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Glu Leu Glu Gly 
        115                 120                 125             


Ser Gly Ser Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Val Asn Glu 
    130                 135                 140                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
145                 150                 155                 160 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                165                 170                 175     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            180                 185                 190         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        195                 200                 205             


Leu Asn Ile Thr Ala Ala Ser Leu Ser Gly Gly Asp Ile Ile Lys Leu 
    210                 215                 220                 


Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met 
225                 230                 235                 240 


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
                245                 250                 255     


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
            260                 265                 270         


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
        275                 280                 285             


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
    290                 295                 300                 


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
305                 310                 315                 320 


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
                325                 330                 335     


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
            340                 345                 350         


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
        355                 360                 365             


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
    370                 375                 380         


<210>  162
<211>  264
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem construct with amino 
       acid substitutions Flu077 - membrane anchoring sequence

<400>  162

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys Leu 
    50                  55                  60                  


Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly 
65                  70                  75                  80  


Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly 
                85                  90                  95      


Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala 
            100                 105                 110         


Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Glu Leu Glu Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Val 
    130                 135                 140                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
145                 150                 155                 160 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn 
                165                 170                 175     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            180                 185                 190         


Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        195                 200                 205             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp 
    210                 215                 220                 


Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala 
225                 230                 235                 240 


Val Thr Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg Asp 
                245                 250                 255     


Asn Val Ser Cys Ser Ile Cys Leu 
            260                 


<210>  163
<211>  384
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem construct with amino 
       acid substitutions Flu077 - SGG linker - Helicobacter pylori 
       ferritin

<400>  163

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Gly 
        35                  40                  45              


Ser Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys Leu 
    50                  55                  60                  


Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly 
65                  70                  75                  80  


Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly 
                85                  90                  95      


Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala 
            100                 105                 110         


Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Glu Leu Glu Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Val 
    130                 135                 140                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
145                 150                 155                 160 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn 
                165                 170                 175     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            180                 185                 190         


Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        195                 200                 205             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Ser Gly Gly Asp Ile Ile 
    210                 215                 220                 


Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu 
225                 230                 235                 240 


Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala 
                245                 250                 255     


Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys 
            260                 265                 270         


Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr 
        275                 280                 285             


Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe 
    290                 295                 300                 


Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn 
305                 310                 315                 320 


Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe 
                325                 330                 335     


Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys 
            340                 345                 350         


Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu 
        355                 360                 365             


Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
    370                 375                 380                 


<210>  164
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions Flu115 - membrane anchoring sequence

<400>  164

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
    530                 535                 540                 


Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr 
545                 550                 555                 560 


Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg Asp Asn Val 
                565                 570                 575     


Ser Cys Ser Ile Cys Leu 
            580         


<210>  165
<211>  702
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions Flu115 - SGG linker - Helicobacter pylori ferritin

<400>  165

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Ser Gly Gly Asp Ile Ile Lys Leu 
    530                 535                 540                 


Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met 
545                 550                 555                 560 


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
                565                 570                 575     


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
            580                 585                 590         


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
        595                 600                 605             


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
    610                 615                 620                 


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
625                 630                 635                 640 


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
                645                 650                 655     


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
            660                 665                 670         


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
        675                 680                 685             


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
    690                 695                 700         


<210>  166
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions Flu159 - membrane anchoring sequence

<400>  166

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
    530                 535                 540                 


Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr 
545                 550                 555                 560 


Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg Asp Asn Val 
                565                 570                 575     


Ser Cys Ser Ile Cys Leu 
            580         


<210>  167
<211>  702
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions Flu159 - SGG linker - Helicobacter pylori ferritin

<400>  167

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Ser Gly Gly Asp Ile Ile Lys Leu 
    530                 535                 540                 


Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met 
545                 550                 555                 560 


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
                565                 570                 575     


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
            580                 585                 590         


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
        595                 600                 605             


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
    610                 615                 620                 


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
625                 630                 635                 640 


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
                645                 650                 655     


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
            660                 665                 670         


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
        675                 680                 685             


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
    690                 695                 700         


<210>  168
<211>  265
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem construct with amino 
       acid substitutions Flu460 - membrane anchoring sequence

<400>  168

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Ile Pro 
        35                  40                  45              


Gly Thr Gly Thr Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala 
    50                  55                  60                  


Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu 
65                  70                  75                  80  


Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser 
                85                  90                  95      


His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln 
            100                 105                 110         


Glu Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Lys Ile 
        115                 120                 125             


Leu Thr Gly Asp Tyr Thr Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    130                 135                 140                 


Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln 
145                 150                 155                 160 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                165                 170                 175     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            180                 185                 190         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        195                 200                 205             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
    210                 215                 220                 


Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu 
225                 230                 235                 240 


Ala Val Thr Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg 
                245                 250                 255     


Asp Asn Val Ser Cys Ser Ile Cys Leu 
            260                 265 


<210>  169
<211>  385
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem construct with amino 
       acid substitutions Flu460 - SGG linker - Helicobacter pylori 
       ferritin

<400>  169

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Ile Pro 
        35                  40                  45              


Gly Thr Gly Thr Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala 
    50                  55                  60                  


Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu 
65                  70                  75                  80  


Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser 
                85                  90                  95      


His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln 
            100                 105                 110         


Glu Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Lys Ile 
        115                 120                 125             


Leu Thr Gly Asp Tyr Thr Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    130                 135                 140                 


Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln 
145                 150                 155                 160 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                165                 170                 175     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            180                 185                 190         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        195                 200                 205             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Ser Gly Gly Asp Ile 
    210                 215                 220                 


Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn 
225                 230                 235                 240 


Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly 
                245                 250                 255     


Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala 
            260                 265                 270         


Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu 
        275                 280                 285             


Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile 
    290                 295                 300                 


Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn 
305                 310                 315                 320 


Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn 
                325                 330                 335     


Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe 
            340                 345                 350         


Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly 
        355                 360                 365             


Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys 
    370                 375                 380                 


Ser 
385 


<210>  170
<211>  265
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem construct with amino 
       acid substitutions Flu474 - membrane anchoring sequence

<400>  170

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Tyr Ala 
        35                  40                  45              


Asp Gly Gly Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys 
    50                  55                  60                  


Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu 
65                  70                  75                  80  


Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His 
                85                  90                  95      


Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu 
            100                 105                 110         


Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Ala Phe Tyr 
        115                 120                 125             


Glu Ala Phe Pro Gly Ala Thr Ser Gln Ile Glu Leu Ala Val Leu Leu 
    130                 135                 140                 


Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln 
145                 150                 155                 160 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                165                 170                 175     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            180                 185                 190         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        195                 200                 205             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
    210                 215                 220                 


Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu 
225                 230                 235                 240 


Ala Val Thr Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg 
                245                 250                 255     


Asp Asn Val Ser Cys Ser Ile Cys Leu 
            260                 265 


<210>  171
<211>  385
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem construct with amino 
       acid substitutions Flu474 - SGG linker - Helicobacter pylori 
       ferritin

<400>  171

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Tyr Ala 
        35                  40                  45              


Asp Gly Gly Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys 
    50                  55                  60                  


Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu 
65                  70                  75                  80  


Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His 
                85                  90                  95      


Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu 
            100                 105                 110         


Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Ala Phe Tyr 
        115                 120                 125             


Glu Ala Phe Pro Gly Ala Thr Ser Gln Ile Glu Leu Ala Val Leu Leu 
    130                 135                 140                 


Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln 
145                 150                 155                 160 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                165                 170                 175     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            180                 185                 190         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        195                 200                 205             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Ser Gly Gly Asp Ile 
    210                 215                 220                 


Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn 
225                 230                 235                 240 


Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly 
                245                 250                 255     


Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala 
            260                 265                 270         


Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu 
        275                 280                 285             


Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile 
    290                 295                 300                 


Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn 
305                 310                 315                 320 


Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn 
                325                 330                 335     


Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe 
            340                 345                 350         


Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly 
        355                 360                 365             


Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys 
    370                 375                 380                 


Ser 
385 


<210>  172
<211>  265
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem construct with amino 
       acid substitutions Flu490 - membrane anchoring sequence

<400>  172

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Gln Ser 
        35                  40                  45              


Gly Gly Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys Leu 
    50                  55                  60                  


Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly 
65                  70                  75                  80  


Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly 
                85                  90                  95      


Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala 
            100                 105                 110         


Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Ala Thr Leu Asp 
        115                 120                 125             


Arg Ile Pro Ser Leu Lys Glu Ser Gln Ile Glu Leu Ala Val Leu Leu 
    130                 135                 140                 


Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln 
145                 150                 155                 160 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                165                 170                 175     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            180                 185                 190         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        195                 200                 205             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
    210                 215                 220                 


Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu 
225                 230                 235                 240 


Ala Val Thr Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg 
                245                 250                 255     


Asp Asn Val Ser Cys Ser Ile Cys Leu 
            260                 265 


<210>  173
<211>  385
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem construct with amino 
       acid substitutions Flu490 - SGG linker - Helicobacter pylori 
       ferritin

<400>  173

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Gln Ser 
        35                  40                  45              


Gly Gly Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys Leu 
    50                  55                  60                  


Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly 
65                  70                  75                  80  


Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly 
                85                  90                  95      


Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala 
            100                 105                 110         


Ile Asn Lys Ile Thr Lys Met Leu Asn Ser Leu Ser Ala Thr Leu Asp 
        115                 120                 125             


Arg Ile Pro Ser Leu Lys Glu Ser Gln Ile Glu Leu Ala Val Leu Leu 
    130                 135                 140                 


Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln 
145                 150                 155                 160 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                165                 170                 175     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            180                 185                 190         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        195                 200                 205             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Ser Gly Gly Asp Ile 
    210                 215                 220                 


Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn 
225                 230                 235                 240 


Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly 
                245                 250                 255     


Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala 
            260                 265                 270         


Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu 
        275                 280                 285             


Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile 
    290                 295                 300                 


Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn 
305                 310                 315                 320 


Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn 
                325                 330                 335     


Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe 
            340                 345                 350         


Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly 
        355                 360                 365             


Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys 
    370                 375                 380                 


Ser 
385 


<210>  174
<211>  282
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem construct with amino 
       acid substitutions Flu523 - membrane anchoring sequence

<400>  174

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Val Ala 
        35                  40                  45              


Ile Pro Asn Thr Ser Tyr Val Val Lys Leu Ala Asn Gly Thr Lys Tyr 
    50                  55                  60                  


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
65                  70                  75                  80  


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
                85                  90                  95      


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
            100                 105                 110         


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser 
        115                 120                 125             


Leu Ser Glu Thr Val Ala Lys Trp Glu Lys Gln Leu Ala Ala Gly Asp 
    130                 135                 140                 


Pro Ser Ala Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu 
145                 150                 155                 160 


Leu Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala 
                165                 170                 175     


Gln Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile 
            180                 185                 190         


Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu 
        195                 200                 205             


Asp Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro 
    210                 215                 220                 


Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly 
225                 230                 235                 240 


Leu Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser 
                245                 250                 255     


Leu Ala Val Thr Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser 
            260                 265                 270         


Arg Asp Asn Val Ser Cys Ser Ile Cys Leu 
        275                 280         


<210>  175
<211>  402
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin stem construct with amino 
       acid substitutions Flu523 - SGG linker - Helicobacter pylori 
       ferritin

<400>  175

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Val Ala 
        35                  40                  45              


Ile Pro Asn Thr Ser Tyr Val Val Lys Leu Ala Asn Gly Thr Lys Tyr 
    50                  55                  60                  


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
65                  70                  75                  80  


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
                85                  90                  95      


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
            100                 105                 110         


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Met Leu Asn Ser 
        115                 120                 125             


Leu Ser Glu Thr Val Ala Lys Trp Glu Lys Gln Leu Ala Ala Gly Asp 
    130                 135                 140                 


Pro Ser Ala Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu 
145                 150                 155                 160 


Leu Val Asn Glu Phe Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala 
                165                 170                 175     


Gln Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile 
            180                 185                 190         


Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu 
        195                 200                 205             


Asp Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro 
    210                 215                 220                 


Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Ser Gly Gly Asp 
225                 230                 235                 240 


Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser 
                245                 250                 255     


Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp 
            260                 265                 270         


Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His 
        275                 280                 285             


Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln 
    290                 295                 300                 


Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln 
305                 310                 315                 320 


Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile 
                325                 330                 335     


Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe 
            340                 345                 350         


Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu 
        355                 360                 365             


Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His 
    370                 375                 380                 


Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg 
385                 390                 395                 400 


Lys Ser 
        


<210>  176
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions Flu209 - membrane anchoring sequence

<400>  176

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Leu Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
    530                 535                 540                 


Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr 
545                 550                 555                 560 


Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg Asp Asn Val 
                565                 570                 575     


Ser Cys Ser Ile Cys Leu 
            580         


<210>  177
<211>  702
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions Flu209 - SGG linker - Helicobacter pylori ferritin

<400>  177

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Leu Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Gln Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Ser Gly Gly Asp Ile Ile Lys Leu 
    530                 535                 540                 


Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met 
545                 550                 555                 560 


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
                565                 570                 575     


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
            580                 585                 590         


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
        595                 600                 605             


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
    610                 615                 620                 


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
625                 630                 635                 640 


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
                645                 650                 655     


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
            660                 665                 670         


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
        675                 680                 685             


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
    690                 695                 700         


<210>  178
<211>  582
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions Flu256 - membrane anchoring sequence

<400>  178

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Phe Ile Ile Asn Ser Glu Asp Ile His Leu Leu Ala Gln Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
    530                 535                 540                 


Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr 
545                 550                 555                 560 


Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg Asp Asn Val 
                565                 570                 575     


Ser Cys Ser Ile Cys Leu 
            580         


<210>  179
<211>  702
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant influenza B haemagglutinin ectodomain with amino acid
       substitutions Flu256 - SGG linker - Helicobacter pylori ferritin

<400>  179

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asp 
    130                 135                 140                 


Ala Pro Gly Arg Pro Tyr Glu Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Phe Ile Ile Asn Ser Glu Asp Ile His Leu Leu Ala Gln Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Ser Gly Gly Asp Ile Ile Lys Leu 
    530                 535                 540                 


Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met 
545                 550                 555                 560 


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
                565                 570                 575     


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
            580                 585                 590         


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
        595                 600                 605             


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
    610                 615                 620                 


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
625                 630                 635                 640 


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
                645                 650                 655     


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
            660                 665                 670         


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
        675                 680                 685             


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
    690                 695                 700         


