                         序列表

<110>  宁波茂行生物医药科技有限公司

<120>  靶向IL13Rα2的通用型CAR-T细胞及其制备方法和应用

<130>  0131-PA-024

<160>  245

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 HCDR1; Hu01 HCDR1;

<400>  1

Ser Arg Asn Gly Met Ser 
1               5       


<210>  2
<211>  17
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 HCDR2; Hu01 HCDR2;

<400>  2

Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  13
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 HCDR3; Hu01 HCDR3;

<400>  3

Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe Asp Val 
1               5                   10              


<210>  4
<211>  29
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 HFR1; Hu01 HFR1

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Asp或Gly

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = Gln或Arg

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = Gln或Arg

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Xaa Leu Val Xaa Pro Gly Gly 
1               5                   10                  15      


Ser Leu Xaa Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  


<210>  5
<211>  14
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 HFR2; Hu01 HFR2

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = Ala或Thr

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = Asp或Gly

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = Lys或Arg

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = Gly或Arg

<400>  5

Trp Val Arg Gln Xaa Pro Xaa Xaa Xaa Leu Glu Trp Val Ala 
1               5                   10                  


<210>  6
<211>  32
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 HFR3; Hu01 HFR3

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Lys或Arg

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = Asn或Ser

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = Lys或Arg

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = Ala或Ser

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = Met或Val

<400>  6

Arg Phe Thr Ile Ser Arg Asp Asn Ala Xaa Asn Xaa Leu Tyr Leu Gln 
1               5                   10                  15      


Met Xaa Ser Leu Xaa Xaa Glu Asp Thr Ala Xaa Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  7
<211>  11
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 HFR4; Hu01 HFR4

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = Ala或Gln

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = Leu或Thr

<400>  7

Trp Gly Xaa Gly Thr Xaa Val Thr Val Ser Ser 
1               5                   10      


<210>  8
<211>  29
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 HFR1

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gln Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  


<210>  9
<211>  14
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 HFR2

<400>  9

Trp Val Arg Gln Thr Pro Asp Arg Arg Leu Glu Trp Val Ala 
1               5                   10                  


<210>  10
<211>  32
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 HFR3

<400>  10

Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  11
<211>  11
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 HFR4

<400>  11

Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  12
<211>  29
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu01 HFR1

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  


<210>  13
<211>  14
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu01 HFR2

<400>  13

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  14
<211>  32
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu01 HFR3

<400>  14

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  15
<211>  11
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu01 HFR4

<400>  15

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  16
<211>  122
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 VH

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gln Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Arg Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  17
<211>  122
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu01 VH

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  18
<211>  122
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 VH; Hu01 VH

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Asp或Gly

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = Gln或Arg

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = Gln或Arg

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa = Ala或Thr

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa = Asp或Gly

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa = Lys或Arg

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa = Gly或Arg

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa = Lys或Arg

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa = Asn或Ser

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa = Lys或Arg

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = Ala或Ser

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa = Met或Val

<220>
<221>  misc_feature
<222>  (114)..(114)
<223>  Xaa = Ala或Gln

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  Xaa = Leu或Thr

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Xaa Leu Val Xaa Pro Gly Gly 
1               5                   10                  15      


Ser Leu Xaa Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Xaa Pro Xaa Xaa Xaa Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Xaa Asn Xaa Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Xaa Ser Leu Xaa Xaa Glu Asp Thr Ala Xaa Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe Asp Val Trp 
            100                 105                 110         


Gly Xaa Gly Thr Xaa Val Thr Val Ser Ser 
        115                 120         


<210>  19
<211>  11
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 LCDR1; Hu01 LCDR1;

<400>  19

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  20
<211>  7
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 LCDR2; Hu01 LCDR2;

<400>  20

Ser Ala Ser Tyr Arg Ser Thr 
1               5           


<210>  21
<211>  9
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 LCDR3; Hu01 LCDR3;

<400>  21

Gln His His Tyr Ser Ala Pro Trp Thr 
1               5                   


<210>  22
<211>  23
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 LFR1; Hu01 LFR1

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = Gln或Val

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = His或Pro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = Lys或Ser

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Phe或Ser

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = Ile或Leu

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = Ala或Thr

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = Ser或Thr

<400>  22

Asp Ile Xaa Met Thr Gln Ser Xaa Xaa Xaa Xaa Ser Xaa Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Xaa Ile Thr Cys 
            20              


<210>  23
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 LFR2; Hu01 LFR2

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = Ile或Lys

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = Lys或Gln

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = Ala或Ser

<400>  23

Trp Tyr Gln Gln Xaa Pro Gly Xaa Xaa Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  24
<211>  32
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 LFR3; Hu01 LFR3

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = Ile或Val

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = Asp或Ser

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = Phe或Leu

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = Ile或Thr

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = Leu或Val

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = Ala或Pro

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = Phe或Leu

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa = Leu或Thr

<400>  24

Gly Xaa Pro Xaa Arg Phe Xaa Gly Ser Gly Ser Gly Thr Asp Phe Xaa 
1               5                   10                  15      


Xaa Xaa Ile Ser Ser Xaa Gln Xaa Glu Asp Xaa Ala Xaa Tyr Tyr Cys 
            20                  25                  30          


<210>  25
<211>  10
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 LFR4; Hu01 LFR4

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = Lys或Thr

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = Leu或Val

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = Asp或Glu

<400>  25

Phe Gly Gly Gly Thr Xaa Xaa Xaa Ile Lys 
1               5                   10  


<210>  26
<211>  23
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 LFR1

<400>  26

Asp Ile Val Met Thr Gln Ser His Lys Phe Ile Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys 
            20              


<210>  27
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 LFR2

<400>  27

Trp Tyr Gln Gln Ile Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  28
<211>  32
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 LFR3

<400>  28

Gly Ile Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Ser 
1               5                   10                  15      


Phe Ile Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Leu Tyr Tyr Cys 
            20                  25                  30          


<210>  29
<211>  10
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 LFR4

<400>  29

Phe Gly Gly Gly Thr Thr Leu Asp Ile Lys 
1               5                   10  


<210>  30
<211>  23
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu01 LFR1

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  31
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu01 LFR2

<400>  31

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  32
<211>  32
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu01 LFR3

<400>  32

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  33
<211>  10
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu01 LFR4

<400>  33

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  34
<211>  107
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 VL

<400>  34

Asp Ile Val Met Thr Gln Ser His Lys Phe Ile Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Ile Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Ser Thr Gly Ile Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Ile Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Leu Tyr Tyr Cys Gln His His Tyr Ser Ala Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Thr Leu Asp Ile Lys 
            100                 105         


<210>  35
<211>  107
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu01 VL

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Ser Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Ser Ala Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  36
<211>  107
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 VL; Hu01 VL

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = Gln或Val

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = His或Pro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = Lys或Ser

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Phe或Ser

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = Ile或Leu

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = Ala或Thr

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa = Ile或Lys

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa = Lys或Gln

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa = Ala或Ser

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa = Ile或Val

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa = Asp或Ser

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  Xaa = Phe或Leu

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa = Ile或Thr

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa = Leu或Val

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa = Ala或Pro

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa = Phe或Leu

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa = Leu或Thr

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  Xaa = Lys或Thr

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa = Leu或Val

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa = Asp或Glu

<400>  36

Asp Ile Xaa Met Thr Gln Ser Xaa Xaa Xaa Xaa Ser Xaa Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Xaa Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Xaa Pro Gly Xaa Xaa Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Ser Thr Gly Xaa Pro Xaa Arg Phe Xaa Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Xaa Xaa Xaa Ile Ser Ser Xaa Gln Xaa 
65                  70                  75                  80  


Glu Asp Xaa Ala Xaa Tyr Tyr Cys Gln His His Tyr Ser Ala Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Xaa Xaa Xaa Ile Lys 
            100                 105         


<210>  37
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  接头1

<400>  37

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  38
<211>  18
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  接头2

<400>  38

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  39
<211>  244
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 scFv VLVH

<400>  39

Asp Ile Val Met Thr Gln Ser His Lys Phe Ile Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Ile Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Ser Thr Gly Ile Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Ile Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Leu Tyr Tyr Cys Gln His His Tyr Ser Ala Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Thr Leu Asp Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Asp Leu Val Arg Pro Gly Gly Ser Leu Gln Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Thr Pro Asp Arg Arg Leu Glu Trp Val Ala Thr Val Ser Ser Gly 
                165                 170                 175     


Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Gly Thr Thr 
    210                 215                 220                 


Ala Leu Ala Thr Arg Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  40
<211>  244
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu01 scFv VLVH

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Ser Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Ser Ala Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Val Ser Ser Gly 
                165                 170                 175     


Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gln Gly Thr Thr 
    210                 215                 220                 


Ala Leu Ala Thr Arg Phe Phe Asp Val Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  41
<211>  244
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 scFv VLVH; Hu01 scFv VLVH

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = Gln或Val

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = His或Pro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = Lys或Ser

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Phe或Ser

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = Ile或Leu

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = Ala或Thr

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa = Ile或Lys

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa = Lys或Gln

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa = Ala或Ser

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa = Ile或Val

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa = Asp或Ser

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  Xaa = Phe或Leu

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa = Ile或Thr

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa = Leu或Val

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa = Ala或Pro

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa = Phe或Leu

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa = Leu或Thr

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  Xaa = Lys或Thr

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa = Leu或Val

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa = Asp或Glu

<220>
<221>  misc_feature
<222>  (132)..(132)
<223>  Xaa = Asp或Gly

<220>
<221>  misc_feature
<222>  (135)..(135)
<223>  Xaa = Gln或Arg

<220>
<221>  misc_feature
<222>  (141)..(141)
<223>  Xaa = Gln或Arg

<220>
<221>  misc_feature
<222>  (162)..(162)
<223>  Xaa = Ala或Thr

<220>
<221>  misc_feature
<222>  (164)..(164)
<223>  Xaa = Asp或Gly

<220>
<221>  misc_feature
<222>  (165)..(165)
<223>  Xaa = Lys或Arg

<220>
<221>  misc_feature
<222>  (166)..(166)
<223>  Xaa = Gly或Arg

<220>
<221>  misc_feature
<222>  (198)..(198)
<223>  Xaa = Lys或Arg

<220>
<221>  misc_feature
<222>  (200)..(200)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (206)..(206)
<223>  Xaa = Asn或Ser

<220>
<221>  misc_feature
<222>  (209)..(209)
<223>  Xaa = Lys或Arg

<220>
<221>  misc_feature
<222>  (210)..(210)
<223>  Xaa = Ala或Ser

<220>
<221>  misc_feature
<222>  (215)..(215)
<223>  Xaa = Met或Val

<220>
<221>  misc_feature
<222>  (236)..(236)
<223>  Xaa = Ala或Gln

<220>
<221>  misc_feature
<222>  (239)..(239)
<223>  Xaa = Leu或Thr

<400>  41

Asp Ile Xaa Met Thr Gln Ser Xaa Xaa Xaa Xaa Ser Xaa Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Xaa Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Xaa Pro Gly Xaa Xaa Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Ser Thr Gly Xaa Pro Xaa Arg Phe Xaa Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Xaa Xaa Xaa Ile Ser Ser Xaa Gln Xaa 
65                  70                  75                  80  


Glu Asp Xaa Ala Xaa Tyr Tyr Cys Gln His His Tyr Ser Ala Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Xaa Xaa Xaa Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Xaa Leu Val Xaa Pro Gly Gly Ser Leu Xaa Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Xaa Pro Xaa Xaa Xaa Leu Glu Trp Val Ala Thr Val Ser Ser Gly 
                165                 170                 175     


Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Xaa Asn Xaa Leu Tyr Leu Gln Met Xaa Ser Leu 
        195                 200                 205             


Xaa Xaa Glu Asp Thr Ala Xaa Tyr Tyr Cys Ala Arg Gln Gly Thr Thr 
    210                 215                 220                 


Ala Leu Ala Thr Arg Phe Phe Asp Val Trp Gly Xaa Gly Thr Xaa Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  42
<211>  244
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 scFv VHVL

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gln Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Arg Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


His Lys Phe Ile Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Ile 
                165                 170                 175     


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Ser 
            180                 185                 190         


Thr Gly Ile Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Ser Phe Ile Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Leu Tyr Tyr 
    210                 215                 220                 


Cys Gln His His Tyr Ser Ala Pro Trp Thr Phe Gly Gly Gly Thr Thr 
225                 230                 235                 240 


Leu Asp Ile Lys 
                


<210>  43
<211>  244
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu01 scFv VHVL

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Ser 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln His His Tyr Ser Ala Pro Trp Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  44
<211>  244
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 scFv VHVL; Hu01 scFv VHVL

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Asp或Gly

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = Gln或Arg

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = Gln或Arg

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa = Ala或Thr

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa = Asp或Gly

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa = Lys或Arg

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa = Gly或Arg

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa = Lys或Arg

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa = Asn或Ser

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa = Lys或Arg

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = Ala或Ser

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa = Met或Val

<220>
<221>  misc_feature
<222>  (114)..(114)
<223>  Xaa = Ala或Gln

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  Xaa = Leu或Thr

<220>
<221>  misc_feature
<222>  (140)..(140)
<223>  Xaa = Gln或Val

<220>
<221>  misc_feature
<222>  (145)..(145)
<223>  Xaa = His或Pro

<220>
<221>  misc_feature
<222>  (146)..(146)
<223>  Xaa = Lys或Ser

<220>
<221>  misc_feature
<222>  (147)..(147)
<223>  Xaa = Phe或Ser

<220>
<221>  misc_feature
<222>  (148)..(148)
<223>  Xaa = Ile或Leu

<220>
<221>  misc_feature
<222>  (150)..(150)
<223>  Xaa = Ala或Thr

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (176)..(176)
<223>  Xaa = Ile或Lys

<220>
<221>  misc_feature
<222>  (179)..(179)
<223>  Xaa = Lys或Gln

<220>
<221>  misc_feature
<222>  (180)..(180)
<223>  Xaa = Ala或Ser

<220>
<221>  misc_feature
<222>  (195)..(195)
<223>  Xaa = Ile或Val

<220>
<221>  misc_feature
<222>  (197)..(197)
<223>  Xaa = Asp或Ser

<220>
<221>  misc_feature
<222>  (200)..(200)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (209)..(209)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (210)..(210)
<223>  Xaa = Phe或Leu

<220>
<221>  misc_feature
<222>  (211)..(211)
<223>  Xaa = Ile或Thr

<220>
<221>  misc_feature
<222>  (215)..(215)
<223>  Xaa = Leu或Val

<220>
<221>  misc_feature
<222>  (217)..(217)
<223>  Xaa = Ala或Pro

<220>
<221>  misc_feature
<222>  (220)..(220)
<223>  Xaa = Phe或Leu

<220>
<221>  misc_feature
<222>  (222)..(222)
<223>  Xaa = Leu或Thr

<220>
<221>  misc_feature
<222>  (240)..(240)
<223>  Xaa = Lys或Thr

<220>
<221>  misc_feature
<222>  (241)..(241)
<223>  Xaa = Leu或Val

<220>
<221>  misc_feature
<222>  (242)..(242)
<223>  Xaa = Asp或Glu

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Xaa Leu Val Xaa Pro Gly Gly 
1               5                   10                  15      


Ser Leu Xaa Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Xaa Pro Xaa Xaa Xaa Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Xaa Asn Xaa Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Xaa Ser Leu Xaa Xaa Glu Asp Thr Ala Xaa Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe Asp Val Trp 
            100                 105                 110         


Gly Xaa Gly Thr Xaa Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Xaa Met Thr Gln Ser 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Ser Xaa Ser Val Gly Asp Arg Val Xaa Ile Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Xaa 
                165                 170                 175     


Pro Gly Xaa Xaa Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Ser 
            180                 185                 190         


Thr Gly Xaa Pro Xaa Arg Phe Xaa Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Xaa Xaa Xaa Ile Ser Ser Xaa Gln Xaa Glu Asp Xaa Ala Xaa Tyr Tyr 
    210                 215                 220                 


Cys Gln His His Tyr Ser Ala Pro Trp Thr Phe Gly Gly Gly Thr Xaa 
225                 230                 235                 240 


Xaa Xaa Ile Lys 
                


<210>  45
<211>  502
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 CAR VLVH;

<400>  45

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser His Lys Phe Ile 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asp Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Ile Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Ser Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Ser Phe Ile Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Leu Tyr Tyr Cys Gln His His 
            100                 105                 110         


Tyr Ser Ala Pro Trp Thr Phe Gly Gly Gly Thr Thr Leu Asp Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Arg Pro Gly Gly Ser 
145                 150                 155                 160 


Leu Gln Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn Gly 
                165                 170                 175     


Met Ser Trp Val Arg Gln Thr Pro Asp Arg Arg Leu Glu Trp Val Ala 
            180                 185                 190         


Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr Leu 
    210                 215                 220                 


Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe Asp Val Trp Gly 
                245                 250                 255     


Ala Gly Thr Thr Val Thr Val Ser Ser Phe Val Pro Val Phe Leu Pro 
            260                 265                 270         


Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        275                 280                 285             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
    290                 295                 300                 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
305                 310                 315                 320 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                325                 330                 335     


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly Arg 
            340                 345                 350         


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
        355                 360                 365             


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
    370                 375                 380                 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
385                 390                 395                 400 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
                405                 410                 415     


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
            420                 425                 430         


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
        435                 440                 445             


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
    450                 455                 460                 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
465                 470                 475                 480 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
                485                 490                 495     


Gln Ala Leu Pro Pro Arg 
            500         


<210>  46
<211>  502
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu01 CAR VHVL

<400>  46

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Asn Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gln Gly Thr Thr Ala Leu Ala Thr Arg 
        115                 120                 125             


Phe Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser 
        195                 200                 205             


Ala Ser Tyr Arg Ser Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
225                 230                 235                 240 


Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Ser Ala Pro Trp Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Val Glu Ile Lys Phe Val Pro Val Phe Leu Pro 
            260                 265                 270         


Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        275                 280                 285             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
    290                 295                 300                 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
305                 310                 315                 320 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                325                 330                 335     


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly Arg 
            340                 345                 350         


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
        355                 360                 365             


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
    370                 375                 380                 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
385                 390                 395                 400 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
                405                 410                 415     


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
            420                 425                 430         


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
        435                 440                 445             


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
    450                 455                 460                 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
465                 470                 475                 480 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
                485                 490                 495     


Gln Ala Leu Pro Pro Arg 
            500         


<210>  47
<211>  366
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 VH核酸序列

<400>  47
gaggtgcagc tggttgagtc tggcggcgat cttgttagac ctggcggaag cctgcagctg       60

tcttgtgccg cttccggctt caccttcagc agaaacggca tgagctgggt ccgacagacc      120

cctgatagac ggctggaatg ggtcgccaca gtgtctagcg gcggcagcta catctactac      180

gccgactctg tgaagggcag attcaccatc tccagagaca acgcccggaa caccctgtac      240

ctgcagatga gcagcctgaa gtccgaggac accgccatgt actactgtgc cagacagggc      300

acaacagccc tggccaccag attcttcgat gtgtggggag ccggaaccac cgtgacagtc      360

tcttct                                                                 366


<210>  48
<211>  366
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu01 VH核酸序列

<400>  48
gaggtgcagc tggtggagtc tggcggcgga ctggtgcagc ctggcggctc tctgagactg       60

tcttgtgccg cctccggctt caccttcagt aggaatggca tgtcttgggt gaggcaggcc      120

cctggcaagg gcctggagtg ggtggccacc gttagtagtg gtggtagtta catctactat      180

gcagacagtg tgaaggggcg gttcaccatc tccagggaca acgccaagaa ctccctgtac      240

ctccagatga actccctgag ggccgaggat accgccgtgt actactgtgc cagacaaggg      300

actacggcac tagctacgag gttcttcgat gtctggggcc agggcaccct ggtgaccgtg      360

tcctct                                                                 366


<210>  49
<211>  321
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 VL核酸序列

<400>  49
gacatcgtga tgacccagag ccacaagttc atcagcacca gcgtgggcga cagagtgtcc       60

atcacctgta aagccagcca ggatgtggga acagccgtgg cctggtatca gcagatccct      120

ggccagtctc ctaagctgct gatctacagc gccagctaca gaagcacagg catccccgat      180

agattcaccg gctctggcag cggcaccgac ttcagcttta tcatcagcag cgtgcaggcc      240

gaggatctgg ccctgtacta ttgccagcac cactactctg ccccttggac ctttggcggc      300

ggaaccacac tggacatcaa g                                                321


<210>  50
<211>  321
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu01 VL核酸序列

<400>  50
gacatccaga tgacccagtc cccctcttct ctgtctgcct ctgtgggcga cagagtgacc       60

atcacctgta aggccagtca ggatgtaggt actgctgtag cctggtatca gcagaagcct      120

ggcaaggctc ccaagctgct gatctactcg gcatcctacc ggtccactgg cgtgccttcc      180

agattctccg gctctggctc tggcaccgat ttcaccctga ccatctcctc cctccagcct      240

gaggatttcg ccacctacta ctgccagcac cattatagtg ctccgtggac gtttggcggc      300

ggaacaaagg tggagatcaa g                                                321


<210>  51
<211>  1506
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  Mu01 CAR VLVH核酸序列;

<400>  51
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcg tgatgaccca gagccacaag ttcatcagca ccagcgtggg cgacagagtg      120

tccatcacct gtaaagccag ccaggatgtg ggaacagccg tggcctggta tcagcagatc      180

cctggccagt ctcctaagct gctgatctac agcgccagct acagaagcac aggcatcccc      240

gatagattca ccggctctgg cagcggcacc gacttcagct ttatcatcag cagcgtgcag      300

gccgaggatc tggccctgta ctattgccag caccactact ctgccccttg gacctttggc      360

ggcggaacca cactggacat caagggaggc ggaggttctg gcggcggagg aagtggtggc      420

ggaggctctg aggtgcagct ggttgagtct ggcggcgatc ttgttagacc tggcggaagc      480

ctgcagctgt cttgtgccgc ttccggcttc accttcagca gaaacggcat gagctgggtc      540

cgacagaccc ctgatagacg gctggaatgg gtcgccacag tgtctagcgg cggcagctac      600

atctactacg ccgactctgt gaagggcaga ttcaccatct ccagagacaa cgcccggaac      660

accctgtacc tgcagatgag cagcctgaag tccgaggaca ccgccatgta ctactgtgcc      720

agacagggca caacagccct ggccaccaga ttcttcgatg tgtggggagc cggaaccacc      780

gtgacagtct cttctttcgt ccccgtgttc ctgcctgcca agccaacaac tacccctgct      840

ccacgaccac ctactccagc acctaccatc gcaagtcagc ccctgtcact gcgacctgag      900

gcttgccggc cagcagctgg aggagcagtg cacacccgag gcctggactt cgcatgcgat      960

atctacattt gggcaccact ggctggaacc tgtggggtcc tgctgctgag cctggtcatc     1020

accctgtatt gtaaccacag aaataaaagg gggcgcaaga aactgctgta catcttcaag     1080

cagcctttta tgcgcccagt gcagacaact caggaggaag acggatgctc ttgtcggttc     1140

ccagaggagg aggaaggagg ctgcgagctg agagtgaagt tcagccggag cgccgatgca     1200

ccagcatatc agcagggaca gaatcagctg tacaacgagc tgaatctggg caggcgcgag     1260

gaatatgacg tgctggataa gcgacgagga cgggaccccg aaatgggagg aaaacccaga     1320

aggaagaacc ctcaggaggg gctgtataat gaactgcaga aagacaagat ggctgaggca     1380

tacagcgaaa ttggaatgaa aggagagcgc cgacggggga agggacacga tgggctgtac     1440

cagggactgt caaccgccac taaagatacc tacgacgcac tgcacatgca ggctctgccc     1500

ccaaga                                                                1506


<210>  52
<211>  1506
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu01 CAR VHVL核酸序列

<400>  52
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggcggc ggactggtgc agcctggcgg ctctctgaga      120

ctgtcttgtg ccgcctccgg cttcaccttc agtaggaatg gcatgtcttg ggtgaggcag      180

gcccctggca agggcctgga gtgggtggcc accgttagta gtggtggtag ttacatctac      240

tatgcagaca gtgtgaaggg gcggttcacc atctccaggg acaacgccaa gaactccctg      300

tacctccaga tgaactccct gagggccgag gataccgccg tgtactactg tgccagacaa      360

gggactacgg cactagctac gaggttcttc gatgtctggg gccagggcac cctggtgacc      420

gtgtcctctg gaggcggagg ttctggcggc ggaggaagtg gtggcggagg ctctgacatc      480

cagatgaccc agtccccctc ttctctgtct gcctctgtgg gcgacagagt gaccatcacc      540

tgtaaggcca gtcaggatgt aggtactgct gtagcctggt atcagcagaa gcctggcaag      600

gctcccaagc tgctgatcta ctcggcatcc taccggtcca ctggcgtgcc ttccagattc      660

tccggctctg gctctggcac cgatttcacc ctgaccatct cctccctcca gcctgaggat      720

ttcgccacct actactgcca gcaccattat agtgctccgt ggacgtttgg cggcggaaca      780

aaggtggaga tcaagttcgt ccccgtgttc ctgcctgcca agccaacaac tacccctgct      840

ccacgaccac ctactccagc acctaccatc gcaagtcagc ccctgtcact gcgacctgag      900

gcttgccggc cagcagctgg aggagcagtg cacacccgag gcctggactt cgcatgcgat      960

atctacattt gggcaccact ggctggaacc tgtggggtcc tgctgctgag cctggtcatc     1020

accctgtatt gtaaccacag aaataaaagg gggcgcaaga aactgctgta catcttcaag     1080

cagcctttta tgcgcccagt gcagacaact caggaggaag acggatgctc ttgtcggttc     1140

ccagaggagg aggaaggagg ctgcgagctg agagtgaagt tcagccggag cgccgatgca     1200

ccagcatatc agcagggaca gaatcagctg tacaacgagc tgaatctggg caggcgcgag     1260

gaatatgacg tgctggataa gcgacgagga cgggaccccg aaatgggagg aaaacccaga     1320

aggaagaacc ctcaggaggg gctgtataat gaactgcaga aagacaagat ggctgaggca     1380

tacagcgaaa ttggaatgaa aggagagcgc cgacggggga agggacacga tgggctgtac     1440

cagggactgt caaccgccac taaagatacc tacgacgcac tgcacatgca ggctctgccc     1500

ccaaga                                                                1506


<210>  53
<211>  6
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu07 HCDR1

<400>  53

Thr Lys Tyr Gly Val His 
1               5       


<210>  54
<211>  16
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu07 HCDR2

<400>  54

Gly Val Lys Trp Ala Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Met 
1               5                   10                  15      


<210>  55
<211>  8
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu07 HCDR3

<400>  55

Asp His Arg Asp Ala Met Asp Tyr 
1               5               


<210>  56
<211>  116
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu07 VH

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Lys Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Lys Trp Ala Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Arg Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  57
<211>  12
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu07 LCDR1

<400>  57

Thr Ala Ser Leu Ser Val Ser Ser Thr Tyr Leu His 
1               5                   10          


<210>  58
<211>  7
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu07 LCDR2

<400>  58

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  59
<211>  9
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu07 LCDR3

<400>  59

His Gln Tyr His Arg Ser Pro Leu Thr 
1               5                   


<210>  60
<211>  108
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu07 VL

<400>  60

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Thr Ala Ser Leu Ser Val Ser Ser Thr 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  61
<211>  239
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu07 scFv VHVL

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Lys Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Lys Trp Ala Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Arg Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Thr Ala Ser Leu Ser Val 
145                 150                 155                 160 


Ser Ser Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro 
                165                 170                 175     


Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr His 
    210                 215                 220                 


Arg Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 


<210>  62
<211>  239
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu07 scFv VLVH

<400>  62

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Thr Ala Ser Leu Ser Val Ser Ser Thr 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Ser Leu Thr Lys Tyr Gly Val His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Val Lys Trp Ala 
                165                 170                 175     


Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Met Ser Arg Phe Thr Ile 
            180                 185                 190         


Ser Lys Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp His Arg Asp 
    210                 215                 220                 


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 


<210>  63
<211>  348
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu07 VH核苷酸序列

<400>  63
gaagtacagc tggttgagag tggcgggggt ctcgtacagc ccggcgggtc tcttaggctc       60

tcctgtgctg cttctggttt ctccttgact aaatacgggg tacattgggt tcgccaggcc      120

cctggcaaag gtcttgaatg ggtgggcgtc aagtgggctg gcggaagcac tgattataat      180

tccgcattga tgtcccgatt cactatttct aaggataatg ccaagaacag tctctatttg      240

caaatgaact ccctgagagc ggaggatact gccgtttact actgtgcacg ggatcaccga      300

gacgctatgg attactgggg tcagggtacc ctggtgaccg taagctcc                   348


<210>  64
<211>  324
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu07 VL核苷酸序列

<400>  64
gacatacaaa tgacacagtc cccctcatcc ttgtctgctt ccgtaggaga ccgggttacc       60

atcacgtgca ccgcttcttt gtccgtttca agtacctacc tccactggta ccagcaaaaa      120

cccggcagca gccccaagtt gtggatttac tcaacttcta acttggcctc aggggtaccg      180

tcaagattta gcggatctgg cagtggcacg agttatactt tgacgatatc aagccttcaa      240

ccggaggatt tcgccaccta ttactgtcat cagtatcatc gaagcccctt gacctttggg      300

ggagggacaa aagtggaaat aaaa                                             324


<210>  65
<211>  648
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu07 scFv VHVL核苷酸序列

<400>  65
gaagtacagc tggttgagag tggcgggggt ctcgtacagc ccggcgggtc tcttaggctc       60

tcctgtgctg cttctggttt ctccttgact aaatacgggg tacattgggt tcgccaggcc      120

cctggcaaag gtcttgaatg ggtgggcgtc aagtgggctg gcggaagcac tgattataat      180

tccgcattga tgtcccgatt cactatttct aaggataatg ccaagaacag tctctatttg      240

caaatgaact ccctgagagc ggaggatact gccgtttact actgtgcacg ggatcaccga      300

gacgctatgg attactgggg tcagggtacc ctggtgaccg taagctccgg gggaggtgga      360

agtggtggcg gtggatctgg tggcggcggg tcagacatac aaatgacaca gtccccctca      420

tccttgtctg cttccgtagg agaccgggtt accatcacgt gcaccgcttc tttgtccgtt      480

tcaagtacct acctccactg gtaccagcaa aaacccggca gcagccccaa gttgtggatt      540

tactcaactt ctaacttggc ctcaggggta ccgtcaagat ttagcggatc tggcagtggc      600

acgagttata ctttgacgat atcaagcctt caaccggagg atttcgcc                   648


<210>  66
<211>  717
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hu07 scFv VLVH核苷酸序列

<400>  66
gacatacaaa tgacacagtc cccctcatcc ttgtctgctt ccgtaggaga ccgggttacc       60

atcacgtgca ccgcttcttt gtccgtttca agtacctacc tccactggta ccagcaaaaa      120

cccggcagca gccccaagtt gtggatttac tcaacttcta acttggcctc aggggtaccg      180

tcaagattta gcggatctgg cagtggcacg agttatactt tgacgatatc aagccttcaa      240

ccggaggatt tcgccaccta ttactgtcat cagtatcatc gaagcccctt gacctttggg      300

ggagggacaa aagtggaaat aaaaggggga ggtggaagtg gtggcggtgg atctggtggc      360

ggcgggtcag aagtacagct ggttgagagt ggcgggggtc tcgtacagcc cggcgggtct      420

cttaggctct cctgtgctgc ttctggtttc tccttgacta aatacggggt acattgggtt      480

cgccaggccc ctggcaaagg tcttgaatgg gtgggcgtca agtgggctgg cggaagcact      540

gattataatt ccgcattgat gtcccgattc actatttcta aggataatgc caagaacagt      600

ctctatttgc aaatgaactc cctgagagcg gaggatactg ccgtttacta ctgtgcacgg      660

gatcaccgag acgctatgga ttactggggt cagggtaccc tggtgaccgt aagctcc         717


<210>  67
<211>  237
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CAR非抗原结合域的氨基酸序列

<400>  67

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    50                  55                  60                  


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
65                  70                  75                  80  


His Arg Asn Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
                85                  90                  95      


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
            100                 105                 110         


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
        115                 120                 125             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
    130                 135                 140                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
145                 150                 155                 160 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                165                 170                 175     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            180                 185                 190         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        195                 200                 205             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    210                 215                 220                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
225                 230                 235         


<210>  68
<211>  711
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CAR非抗原结合域的DNA序列

<400>  68
ttcgtccccg tgttcctgcc tgccaagcca acaactaccc ctgctccacg accacctact       60

ccagcaccta ccatcgcaag tcagcccctg tcactgcgac ctgaggcttg ccggccagca      120

gctggaggag cagtgcacac ccgaggcctg gacttcgcat gcgatatcta catttgggca      180

ccactggctg gaacctgtgg ggtcctgctg ctgagcctgg tcatcaccct gtattgtaac      240

cacagaaata aaagggggcg caagaaactg ctgtacatct tcaagcagcc ttttatgcgc      300

ccagtgcaga caactcagga ggaagacgga tgctcttgtc ggttcccaga ggaggaggaa      360

ggaggctgcg agctgagagt gaagttcagc cggagcgccg atgcaccagc atatcagcag      420

ggacagaatc agctgtacaa cgagctgaat ctgggcaggc gcgaggaata tgacgtgctg      480

gataagcgac gaggacggga ccccgaaatg ggaggaaaac ccagaaggaa gaaccctcag      540

gaggggctgt ataatgaact gcagaaagac aagatggctg aggcatacag cgaaattgga      600

atgaaaggag agcgccgacg ggggaaggga cacgatgggc tgtaccaggg actgtcaacc      660

gccactaaag atacctacga cgcactgcac atgcaggctc tgcccccaag a               711


<210>  69
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD8A跨膜域

<400>  69

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  70
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD8B跨膜域

<400>  70

Ile Thr Leu Gly Leu Leu Val Ala Gly Val Leu Val Leu Leu Val Ser 
1               5                   10                  15      


Leu Gly Val Ala Ile 
            20      


<210>  71
<211>  27
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD28跨膜域

<400>  71

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  72
<211>  27
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4-1BB跨膜域

<400>  72

Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210>  73
<211>  22
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD4跨膜域

<400>  73

Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
1               5                   10                  15      


Gly Leu Gly Ile Phe Phe 
            20          


<210>  74
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD27跨膜域

<400>  74

Ile Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly 
1               5                   10                  15      


Ala Leu Phe Leu His 
            20      


<210>  75
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD7跨膜域

<400>  75

Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu Gly Leu Gly Val 
1               5                   10                  15      


Ala Cys Val Leu Ala 
            20      


<210>  76
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  PD-1跨膜域

<400>  76

Val Gly Val Val Gly Gly Leu Leu Gly Ser Leu Val Leu Leu Val Trp 
1               5                   10                  15      


Val Leu Ala Val Ile 
            20      


<210>  77
<211>  23
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  TRAC跨膜域

<400>  77

Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
1               5                   10                  15      


Leu Met Thr Leu Arg Leu Trp 
            20              


<210>  78
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  TRBC跨膜域

<400>  78

Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu 
1               5                   10                  15      


Val Leu Met Ala Met 
            20      


<210>  79
<211>  26
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD3e跨膜域；CD3ε跨膜域

<400>  79

Val Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly 
1               5                   10                  15      


Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
            20                  25      


<210>  80
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD3ζ跨膜域

<400>  80

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu 
            20      


<210>  81
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CTLA-4跨膜域

<400>  81

Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe Tyr 
1               5                   10                  15      


Ser Phe Leu Leu Thr 
            20      


<210>  82
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LAG-3跨膜域

<400>  82

Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu Val Thr 
1               5                   10                  15      


Gly Ala Phe Gly Phe 
            20      


<210>  83
<211>  30
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD5跨膜域

<400>  83

Ala Gly Leu Ala Ala Gly Thr Val Ala Ser Ile Ile Leu Ala Leu Val 
1               5                   10                  15      


Leu Leu Val Val Leu Leu Val Val Cys Gly Pro Leu Ala Tyr 
            20                  25                  30  


<210>  84
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  ICOS跨膜域

<400>  84

Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
1               5                   10                  15      


Gly Cys Ile Leu Ile 
            20      


<210>  85
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  OX40跨膜域

<400>  85

Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu 
            20      


<210>  86
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  NKG2D跨膜域

<400>  86

Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly Ile Arg Phe 
1               5                   10                  15      


Ile Ile Met Val Ala 
            20      


<210>  87
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  2B4跨膜域；CD244跨膜域

<400>  87

Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu Phe Leu Gly Thr Leu 
1               5                   10                  15      


Ala Cys Phe Cys Val 
            20      


<210>  88
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  FcεRIγ跨膜域

<400>  88

Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu Tyr Gly Ile Val Leu 
1               5                   10                  15      


Thr Leu Leu Tyr Cys 
            20      


<210>  89
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  BTLA跨膜域

<400>  89

Leu Leu Pro Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys 
1               5                   10                  15      


Leu Phe Cys Cys Leu 
            20      


<210>  90
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD30跨膜域

<400>  90

Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly Ser 
1               5                   10                  15      


Ser Ala Phe Leu Leu 
            20      


<210>  91
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  GITR跨膜域

<400>  91

Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys Val Leu 
1               5                   10                  15      


Leu Leu Thr Ser Ala 
            20      


<210>  92
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HVEM跨膜域

<400>  92

Trp Trp Phe Leu Ser Gly Ser Leu Val Ile Val Ile Val Cys Ser Thr 
1               5                   10                  15      


Val Gly Leu Ile Ile 
            20      


<210>  93
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  DAP10跨膜域

<400>  93

Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
1               5                   10                  15      


Val Gly Ala Val Phe 
            20      


<210>  94
<211>  26
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD2跨膜域

<400>  94

Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met Val 
1               5                   10                  15      


Phe Val Ala Leu Leu Val Phe Tyr Ile Thr 
            20                  25      


<210>  95
<211>  23
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  NKG2C跨膜域

<400>  95

Leu Thr Ala Glu Val Leu Gly Ile Ile Cys Ile Val Leu Met Ala Thr 
1               5                   10                  15      


Val Leu Lys Thr Ile Val Leu 
            20              


<210>  96
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LIGHT跨膜域

<400>  96

Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly Ala Gly Leu Ala Val 
1               5                   10                  15      


Gln Gly Trp Phe Leu 
            20      


<210>  97
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  DAP12跨膜域

<400>  97

Gly Val Leu Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu 
1               5                   10                  15      


Ile Ala Leu Ala Val 
            20      


<210>  98
<211>  24
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD40L跨膜域；CD154跨膜域

<400>  98

Ile Phe Met Tyr Leu Leu Thr Val Phe Leu Ile Thr Gln Met Ile Gly 
1               5                   10                  15      


Ser Ala Leu Phe Ala Val Tyr Leu 
            20                  


<210>  99
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  TIM1跨膜域

<400>  99

Ile Tyr Ala Gly Val Cys Ile Ser Val Leu Val Leu Leu Ala Leu Leu 
1               5                   10                  15      


Gly Val Ile Ile Ala 
            20      


<210>  100
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD226跨膜域

<400>  100

Gly Gly Thr Val Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile 
1               5                   10                  15      


Ile Val Ile Phe Leu 
            20      


<210>  101
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  DR3跨膜域

<400>  101

Met Phe Trp Val Gln Val Leu Leu Ala Gly Leu Val Val Pro Leu Leu 
1               5                   10                  15      


Leu Gly Ala Thr Leu 
            20      


<210>  102
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD45跨膜域

<400>  102

Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala 
1               5                   10                  15      


Leu Leu Val Val Leu 
            20      


<210>  103
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD80跨膜域

<400>  103

Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe 
1               5                   10                  15      


Val Ile Cys Cys Leu 
            20      


<210>  104
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD86跨膜域

<400>  104

Trp Ile Thr Ala Val Leu Pro Thr Val Ile Ile Cys Val Met Val Phe 
1               5                   10                  15      


Cys Leu Ile Leu Trp 
            20      


<210>  105
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD9跨膜域1

<400>  105

Leu Leu Phe Gly Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val 
1               5                   10                  15      


Leu Ala Ile Gly Leu 
            20      


<210>  106
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD9跨膜域2

<400>  106

Phe Tyr Thr Gly Val Tyr Ile Leu Ile Gly Ala Gly Ala Leu Met Met 
1               5                   10                  15      


Leu Val Gly Phe Leu 
            20      


<210>  107
<211>  24
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD9跨膜域3

<400>  107

Met Leu Gly Leu Phe Phe Gly Phe Leu Leu Val Ile Phe Ala Ile Glu 
1               5                   10                  15      


Ile Ala Ala Ala Ile Trp Gly Tyr 
            20                  


<210>  108
<211>  26
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD9跨膜域4

<400>  108

Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile Phe Gly Met 
1               5                   10                  15      


Ile Phe Ser Met Ile Leu Cys Cys Ala Ile 
            20                  25      


<210>  109
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD16跨膜域

<400>  109

Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
1               5                   10                  15      


Leu Tyr Phe Ser Val 
            20      


<210>  110
<211>  19
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD22跨膜域

<400>  110

Val Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile 
1               5                   10                  15      


Cys Gly Leu 
            


<210>  111
<211>  23
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD33跨膜域

<400>  111

Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Cys Leu Ile Phe Phe Ile Val 
            20              


<210>  112
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD37跨膜域1

<400>  112

Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe Gly 
1               5                   10                  15      


Ile Trp Ile Leu Ile 
            20      


<210>  113
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD37跨膜域2

<400>  113

Val Leu Ala Ile Ser Gly Ile Phe Thr Met Gly Ile Ala Leu Leu 
1               5                   10                  15  


<210>  114
<211>  26
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD37跨膜域3

<400>  114

Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu Leu Phe Ala Thr Gln 
1               5                   10                  15      


Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln 
            20                  25      


<210>  115
<211>  25
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD37跨膜域4

<400>  115

Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu Leu 
1               5                   10                  15      


Gly Phe Met Thr Leu Ser Ile Phe Leu 
            20                  25  


<210>  116
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD64跨膜域

<400>  116

Val Leu Phe Tyr Leu Ala Val Gly Ile Met Phe Leu Val Asn Thr Val 
1               5                   10                  15      


Leu Trp Val Thr Ile 
            20      


<210>  117
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  SLAM跨膜域

<400>  117

Trp Ala Val Tyr Ala Gly Leu Leu Gly Gly Val Ile Met Ile Leu Ile 
1               5                   10                  15      


Met Val Val Ile Leu 
            20      


<210>  118
<211>  41
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD28胞内共刺激信号传导结构域

<400>  118

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  119
<211>  42
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4-1BB胞内共刺激信号传导结构域

<400>  119

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  120
<211>  48
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD27胞内共刺激信号传导结构域

<400>  120

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  121
<211>  116
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD2胞内共刺激信号传导结构域

<400>  121

Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr 
1               5                   10                  15      


Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln 
            20                  25                  30          


Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro 
        35                  40                  45              


Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro 
    50                  55                  60                  


Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro 
                85                  90                  95      


Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser 
            100                 105                 110         


Pro Ser Ser Asn 
        115     


<210>  122
<211>  39
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD7胞内共刺激信号传导结构域

<400>  122

Arg Thr Gln Ile Lys Lys Leu Cys Ser Trp Arg Asp Lys Asn Ser Ala 
1               5                   10                  15      


Ala Cys Val Val Tyr Glu Asp Met Ser His Ser Arg Cys Asn Thr Leu 
            20                  25                  30          


Ser Ser Pro Asn Gln Tyr Gln 
        35                  


<210>  123
<211>  32
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD8A胞内共刺激信号传导结构域

<400>  123

Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg 
1               5                   10                  15      


Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
            20                  25                  30          


<210>  124
<211>  19
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD8B胞内共刺激信号传导结构域

<400>  124

His Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln 
1               5                   10                  15      


Phe Tyr Lys 
            


<210>  125
<211>  42
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  OX40胞内共刺激信号传导结构域

<400>  125

Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210>  126
<211>  61
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD226胞内共刺激信号传导结构域

<400>  126

Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Thr Glu Ser Trp 
1               5                   10                  15      


Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile Ser Thr Ser 
            20                  25                  30          


Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg Glu Asp Ile Tyr Val 
        35                  40                  45              


Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr Arg Val 
    50                  55                  60      


<210>  127
<211>  197
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  DR3胞内共刺激信号传导结构域

<400>  127

Thr Tyr Thr Tyr Arg His Cys Trp Pro His Lys Pro Leu Val Thr Ala 
1               5                   10                  15      


Asp Glu Ala Gly Met Glu Ala Leu Thr Pro Pro Pro Ala Thr His Leu 
            20                  25                  30          


Ser Pro Leu Asp Ser Ala His Thr Leu Leu Ala Pro Pro Asp Ser Ser 
        35                  40                  45              


Glu Lys Ile Cys Thr Val Gln Leu Val Gly Asn Ser Trp Thr Pro Gly 
    50                  55                  60                  


Tyr Pro Glu Thr Gln Glu Ala Leu Cys Pro Gln Val Thr Trp Ser Trp 
65                  70                  75                  80  


Asp Gln Leu Pro Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr Leu 
                85                  90                  95      


Ser Pro Glu Ser Pro Ala Gly Ser Pro Ala Met Met Leu Gln Pro Gly 
            100                 105                 110         


Pro Gln Leu Tyr Asp Val Met Asp Ala Val Pro Ala Arg Arg Trp Lys 
        115                 120                 125             


Glu Phe Val Arg Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala Val 
    130                 135                 140                 


Glu Val Glu Ile Gly Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu Lys 
145                 150                 155                 160 


Arg Trp Arg Gln Gln Gln Pro Ala Gly Leu Gly Ala Val Tyr Ala Ala 
                165                 170                 175     


Leu Glu Arg Met Gly Leu Asp Gly Cys Val Glu Asp Leu Arg Ser Arg 
            180                 185                 190         


Leu Gln Arg Gly Pro 
        195         


<210>  128
<211>  77
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  SLAM胞内共刺激信号传导结构域

<400>  128

Gln Leu Arg Arg Arg Gly Lys Thr Asn His Tyr Gln Thr Thr Val Glu 
1               5                   10                  15      


Lys Lys Ser Leu Thr Ile Tyr Ala Gln Val Gln Lys Pro Gly Pro Leu 
            20                  25                  30          


Gln Lys Lys Leu Asp Ser Phe Pro Ala Gln Asp Pro Cys Thr Thr Ile 
        35                  40                  45              


Tyr Val Ala Ala Thr Glu Pro Val Pro Glu Ser Val Gln Glu Thr Asn 
    50                  55                  60                  


Ser Ile Thr Val Tyr Ala Ser Val Thr Leu Pro Glu Ser 
65                  70                  75          


<210>  129
<211>  29
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  ICAM-1胞内共刺激信号传导结构域

<400>  129

Asn Arg Gln Arg Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys 
1               5                   10                  15      


Gly Thr Pro Met Lys Pro Asn Thr Gln Ala Thr Pro Pro 
            20                  25                  


<210>  130
<211>  51
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  NKG2D胞内共刺激信号传导结构域

<400>  130

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser 
    50      


<210>  131
<211>  70
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  NKG2C胞内共刺激信号传导结构域

<400>  131

Met Ser Lys Gln Arg Gly Thr Phe Ser Glu Val Ser Leu Ala Gln Asp 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Pro Lys Gly Asn Lys Ser Ser Ile Ser 
            20                  25                  30          


Gly Thr Glu Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Pro 
        35                  40                  45              


Ser Leu Asn His Gln Gly Ile Asp Lys Ile Tyr Asp Cys Gln Gly Leu 
    50                  55                  60                  


Leu Pro Pro Pro Glu Lys 
65                  70  


<210>  132
<211>  47
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  B7-H3胞内共刺激信号传导结构域

<400>  132

Cys Trp Arg Lys Ile Lys Gln Ser Cys Glu Glu Glu Asn Ala Gly Ala 
1               5                   10                  15      


Glu Asp Gln Asp Gly Glu Gly Glu Gly Ser Lys Thr Ala Leu Gln Pro 
            20                  25                  30          


Leu Lys His Ser Asp Ser Lys Glu Asp Asp Gly Gln Glu Ile Ala 
        35                  40                  45          


<210>  133
<211>  120
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  2B4胞内共刺激信号传导结构域；CD244胞内共刺激信号传导结构域

<400>  133

Trp Arg Arg Lys Arg Lys Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu 
1               5                   10                  15      


Phe Leu Thr Ile Tyr Glu Asp Val Lys Asp Leu Lys Thr Arg Arg Asn 
            20                  25                  30          


His Glu Gln Glu Gln Thr Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser 
        35                  40                  45              


Met Ile Gln Ser Gln Ser Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr 
    50                  55                  60                  


Thr Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys 
65                  70                  75                  80  


Arg Asn His Ser Pro Ser Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly 
                85                  90                  95      


Lys Ser Gln Pro Lys Ala Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu 
            100                 105                 110         


Leu Glu Asn Phe Asp Val Tyr Ser 
        115                 120 


<210>  134
<211>  42
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  FcεRIγ胞内共刺激信号传导结构域；FcεRIγ胞内信号转导结构域

<400>  134

Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys 
1               5                   10                  15      


Ser Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr 
            20                  25                  30          


Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
        35                  40          


<210>  135
<211>  111
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  BTLA胞内共刺激信号传导结构域

<400>  135

Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala Gly Arg 
1               5                   10                  15      


Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr Glu Ala 
            20                  25                  30          


Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly Ile Tyr 
        35                  40                  45              


Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser Glu Val 
    50                  55                  60                  


Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val Tyr Ala 
65                  70                  75                  80  


Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu Ala Arg Asn 
                85                  90                  95      


Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg Ser 
            100                 105                 110     


<210>  136
<211>  58
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  GITR胞内共刺激信号传导结构域

<400>  136

Gln Leu Gly Leu His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro 
1               5                   10                  15      


Arg Glu Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala 
            20                  25                  30          


Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu 
        35                  40                  45              


Glu Lys Gly Arg Leu Gly Asp Leu Trp Val 
    50                  55              


<210>  137
<211>  60
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HVEM胞内共刺激信号传导结构域

<400>  137

Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val 
1               5                   10                  15      


Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile 
            20                  25                  30          


Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu 
        35                  40                  45              


Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
    50                  55                  60  


<210>  138
<211>  24
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  DAP10胞内共刺激信号传导结构域；DAP10胞内信号转导结构域

<400>  138

Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val 
1               5                   10                  15      


Tyr Ile Asn Met Pro Gly Arg Gly 
            20                  


<210>  139
<211>  52
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  DAP12胞内共刺激信号传导结构域；DAP-12胞内信号转导结构域

<400>  139

Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala 
1               5                   10                  15      


Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu 
            20                  25                  30          


Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg 
        35                  40                  45              


Pro Tyr Tyr Lys 
    50          


<210>  140
<211>  189
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD30胞内共刺激信号传导结构域

<400>  140

Cys His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu 
1               5                   10                  15      


Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser 
            20                  25                  30          


Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr 
        35                  40                  45              


Glu Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu 
    50                  55                  60                  


Thr Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln 
65                  70                  75                  80  


Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu 
                85                  90                  95      


Pro Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr 
            100                 105                 110         


Ile Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu 
        115                 120                 125             


Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu 
    130                 135                 140                 


Glu Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu 
145                 150                 155                 160 


Pro Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu 
                165                 170                 175     


Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            180                 185                 


<210>  141
<211>  62
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD40胞内共刺激信号传导结构域

<400>  141

Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
1               5                   10                  15      


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
            20                  25                  30          


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
        35                  40                  45              


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    50                  55                  60          


<210>  142
<211>  22
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD40L胞内共刺激信号传导结构域

<400>  142

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys 
            20          


<210>  143
<211>  48
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  TIM1胞内共刺激信号传导结构域

<400>  143

Lys Lys Tyr Phe Phe Lys Lys Glu Val Gln Gln Leu Ser Val Ser Phe 
1               5                   10                  15      


Ser Ser Leu Gln Ile Lys Ala Leu Gln Asn Ala Val Glu Lys Glu Val 
            20                  25                  30          


Gln Ala Glu Asp Asn Ile Tyr Ile Glu Asn Ser Leu Tyr Ala Thr Asp 
        35                  40                  45              


<210>  144
<211>  97
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  PD-1胞内共刺激信号传导结构域

<400>  144

Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln 
1               5                   10                  15      


Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr 
            20                  25                  30          


Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val 
        35                  40                  45              


Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser 
    50                  55                  60                  


Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro 
65                  70                  75                  80  


Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro 
                85                  90                  95      


Leu 
    


<210>  145
<211>  59
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LFA-1胞内共刺激信号传导结构域

<400>  145

Tyr Lys Val Gly Phe Phe Lys Arg Asn Leu Lys Glu Lys Met Glu Ala 
1               5                   10                  15      


Gly Arg Gly Val Pro Asn Gly Ile Pro Ala Glu Asp Ser Glu Gln Leu 
            20                  25                  30          


Ala Ser Gly Gln Glu Ala Gly Asp Pro Gly Cys Leu Lys Pro Leu His 
        35                  40                  45              


Glu Lys Asp Ser Glu Ser Gly Gly Gly Lys Asp 
    50                  55                  


<210>  146
<211>  182
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LIGHT胞内共刺激信号传导结构域

<400>  146

Leu Gln Leu His Trp Arg Leu Gly Glu Met Val Thr Arg Leu Pro Asp 
1               5                   10                  15      


Gly Pro Ala Gly Ser Trp Glu Gln Leu Ile Gln Glu Arg Arg Ser His 
            20                  25                  30          


Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr 
        35                  40                  45              


Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe 
    50                  55                  60                  


Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala 
65                  70                  75                  80  


Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys 
                85                  90                  95      


Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr 
            100                 105                 110         


Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro 
        115                 120                 125             


Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe 
    130                 135                 140                 


Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Lys Val Val Val Arg 
145                 150                 155                 160 


Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr 
                165                 170                 175     


Phe Gly Ala Phe Met Val 
            180         


<210>  147
<211>  98
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  JAML胞内共刺激信号传导结构域

<400>  147

Lys Lys Thr Cys Gly Asn Lys Ser Ser Val Asn Ser Thr Val Leu Val 
1               5                   10                  15      


Lys Asn Thr Lys Lys Thr Asn Pro Glu Ile Lys Glu Lys Pro Cys His 
            20                  25                  30          


Phe Glu Arg Cys Glu Gly Glu Lys His Ile Tyr Ser Pro Ile Ile Val 
        35                  40                  45              


Arg Glu Val Ile Glu Glu Glu Glu Pro Ser Glu Lys Ser Glu Ala Thr 
    50                  55                  60                  


Tyr Met Thr Met His Pro Val Trp Pro Ser Leu Arg Ser Asp Arg Asn 
65                  70                  75                  80  


Asn Ser Leu Glu Lys Lys Ser Gly Gly Gly Met Pro Lys Thr Gln Gln 
                85                  90                  95      


Ala Phe 
        


<210>  148
<211>  107
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD100胞内共刺激信号传导结构域

<400>  148

Tyr Lys Gly Tyr Leu Pro Arg Gln Cys Leu Lys Phe Arg Ser Ala Leu 
1               5                   10                  15      


Leu Ile Gly Lys Lys Lys Pro Lys Ser Asp Phe Cys Asp Arg Glu Gln 
            20                  25                  30          


Ser Leu Lys Glu Thr Leu Val Glu Pro Gly Ser Phe Ser Gln Gln Asn 
        35                  40                  45              


Gly Glu His Pro Lys Pro Ala Leu Asp Thr Gly Tyr Glu Thr Glu Gln 
    50                  55                  60                  


Asp Thr Ile Thr Ser Lys Val Pro Thr Asp Arg Glu Asp Ser Gln Arg 
65                  70                  75                  80  


Ile Asp Asp Leu Ser Ala Arg Asp Lys Pro Phe Asp Val Lys Cys Glu 
                85                  90                  95      


Leu Lys Phe Ala Asp Ser Asp Ala Asp Gly Asp 
            100                 105         


<210>  149
<211>  38
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  ICOS胞内共刺激信号传导结构域

<400>  149

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  150
<211>  296
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  MyD88胞内共刺激信号传导结构域

<400>  150

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp 
            100                 105                 110         


Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro 
        115                 120                 125             


Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu 
    130                 135                 140                 


Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg 
145                 150                 155                 160 


Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln 
                165                 170                 175     


Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys 
            180                 185                 190         


Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala 
        195                 200                 205             


Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met Val Val Val Val Ser 
    210                 215                 220                 


Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe Gln Thr Lys Phe Ala 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Ala His Gln Lys Arg Leu Ile Pro Ile Lys 
                245                 250                 255     


Tyr Lys Ala Met Lys Lys Glu Phe Pro Ser Ile Leu Arg Phe Ile Thr 
            260                 265                 270         


Val Cys Asp Tyr Thr Asn Pro Cys Thr Lys Ser Trp Phe Trp Thr Arg 
        275                 280                 285             


Leu Ala Lys Ala Leu Ser Leu Pro 
    290                 295     


<210>  151
<211>  113
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD3ζ胞内信号转导结构域

<400>  151

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  152
<211>  45
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD3δ胞内信号转导结构域

<400>  152

Gly His Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu 
1               5                   10                  15      


Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala 
            20                  25                  30          


Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
        35                  40                  45  


<210>  153
<211>  45
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD3γ胞内信号转导结构域

<400>  153

Gly Gln Asp Gly Val Arg Gln Ser Arg Ala Ser Asp Lys Gln Thr Leu 
1               5                   10                  15      


Leu Pro Asn Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp 
            20                  25                  30          


Gln Tyr Ser His Leu Gln Gly Asn Gln Leu Arg Arg Asn 
        35                  40                  45  


<210>  154
<211>  55
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD3ε胞内信号转导结构域

<400>  154

Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala 
1               5                   10                  15      


Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro 
            20                  25                  30          


Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
        35                  40                  45              


Gly Leu Asn Gln Arg Arg Ile 
    50                  55  


<210>  155
<211>  61
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD79a胞内信号转导结构域

<400>  155

Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu Asp Ala Gly Asp Glu 
1               5                   10                  15      


Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser 
            20                  25                  30          


Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly Thr Tyr Gln Asp Val 
        35                  40                  45              


Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu Lys Pro 
    50                  55                  60      


<210>  156
<211>  49
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD79b胞内信号转导结构域

<400>  156

Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu Asp His Thr Tyr 
1               5                   10                  15      


Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu Asp Ile Val Thr 
            20                  25                  30          


Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu His Pro Gly Gln 
        35                  40                  45              


Glu 
    


<210>  157
<211>  44
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  FceRIβ胞内信号转导结构域

<400>  157

Ile Cys Gly Ala Gly Glu Glu Leu Lys Gly Asn Lys Val Pro Glu Asp 
1               5                   10                  15      


Arg Val Tyr Glu Glu Leu Asn Ile Tyr Ser Ala Thr Tyr Ser Glu Leu 
            20                  25                  30          


Glu Asp Pro Gly Glu Met Ser Pro Pro Ile Asp Leu 
        35                  40                  


<210>  158
<211>  77
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  FcγRIIa胞内信号转导结构域

<400>  158

Cys Arg Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala 
1               5                   10                  15      


Ala Gln Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg 
            20                  25                  30          


Gln Leu Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr 
        35                  40                  45              


Met Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr 
    50                  55                  60                  


Leu Thr Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
65                  70                  75          


<210>  159
<211>  58
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  牛白血病病毒gp30胞内信号转导结构域

<400>  159

Lys Cys Leu Thr Ser Arg Leu Leu Lys Leu Leu Arg Gln Ala Pro His 
1               5                   10                  15      


Phe Pro Glu Ile Ser Phe Pro Pro Lys Pro Asp Ser Asp Tyr Gln Ala 
            20                  25                  30          


Leu Leu Pro Ser Ala Pro Glu Ile Tyr Ser His Leu Ser Pro Thr Lys 
        35                  40                  45              


Pro Asp Tyr Ile Asn Leu Arg Pro Cys Pro 
    50                  55              


<210>  160
<211>  123
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Epstein-Barr病毒(EBV)LMP2A胞内信号转导结构域

<400>  160

Met Gly Ser Leu Glu Met Val Pro Met Gly Ala Gly Pro Pro Ser Pro 
1               5                   10                  15      


Gly Gly Asp Pro Asp Gly Tyr Asp Gly Gly Asn Asn Ser Gln Tyr Pro 
            20                  25                  30          


Ser Ala Ser Gly Ser Ser Gly Asn Thr Pro Thr Pro Pro Asn Asp Glu 
        35                  40                  45              


Glu Arg Glu Ser Asn Glu Glu Pro Pro Pro Pro Tyr Glu Asp Pro Tyr 
    50                  55                  60                  


Trp Gly Asn Gly Asp Arg His Ser Asp Tyr Gln Pro Leu Gly Thr Gln 
65                  70                  75                  80  


Asp Gln Ser Leu Tyr Leu Gly Leu Gln His Asp Gly Asn Asp Gly Leu 
                85                  90                  95      


Pro Pro Pro Pro Tyr Ser Pro Arg Asp Asp Ser Ser Gln His Ile Tyr 
            100                 105                 110         


Glu Glu Ala Gly Arg Gly Ser Met Asn Pro Val 
        115                 120             


<210>  161
<211>  260
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  猿免疫缺陷病毒PBj14 Nef胞内信号转导结构域

<400>  161

Gly Gly Val Thr Ser Lys Lys Gln Arg Arg Arg Gly Gly Asn Leu Tyr 
1               5                   10                  15      


Glu Arg Leu Leu Gln Ala Arg Gly Glu Thr Tyr Gly Arg Leu Trp Glu 
            20                  25                  30          


Gly Leu Glu Gly Glu Tyr Ser Gln Ser Gln Asp Ala Ser Gly Lys Gly 
        35                  40                  45              


Leu Ser Ser Leu Ser Cys Glu Pro Gln Lys Tyr Cys Glu Gly Gln Phe 
    50                  55                  60                  


Met Asn Thr Pro Trp Arg Asn Pro Ala Thr Glu Arg Ala Lys Leu Asp 
65                  70                  75                  80  


Tyr Arg Gln Gln Asn Met Asp Asp Val Asp Ser Ala Asp Leu Val Gly 
                85                  90                  95      


Cys Pro Val Ser Pro Arg Val Pro Val Arg Ile Met Thr Tyr Lys Leu 
            100                 105                 110         


Ala Ile Asp Met Ser His Phe Ile Lys Glu Lys Gly Gly Leu Glu Gly 
        115                 120                 125             


Ile Tyr Tyr Ser Asp Arg Arg His Lys Ile Leu Asp Leu Tyr Leu Glu 
    130                 135                 140                 


Lys Glu Glu Gly Ile Ile Pro Asp Trp Gln Asn Tyr Thr Ala Gly Pro 
145                 150                 155                 160 


Gly Ile Arg Tyr Pro Met Phe Phe Gly Trp Leu Trp Lys Leu Val Pro 
                165                 170                 175     


Val Asn Val Ser Asp Glu Ala Gln Glu Asp Glu Thr His Tyr Leu Met 
            180                 185                 190         


His Pro Ala Gln Thr Ser Gln Trp Asp Asp Pro Trp Gly Glu Val Leu 
        195                 200                 205             


Ala Trp Lys Phe Asp Pro Lys Leu Ala Tyr Asn Tyr Lys Ala Phe Val 
    210                 215                 220                 


Glu His Pro Glu Glu Phe Gly Ser Gln Ser Gly Leu Ser Lys Glu Glu 
225                 230                 235                 240 


Val Gln Arg Arg Leu Thr Ala Arg Gly Leu Leu Lys Met Ala Asp Lys 
                245                 250                 255     


Lys Lys Thr Ser 
            260 


<210>  162
<211>  134
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD28 铰链区

<400>  162

Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn 
1               5                   10                  15      


Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu 
            20                  25                  30          


Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys 
        35                  40                  45              


Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr 
    50                  55                  60                  


Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile 
                85                  90                  95      


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
            100                 105                 110         


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
        115                 120                 125             


Pro Gly Pro Ser Lys Pro 
    130                 


<210>  163
<211>  220
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  IgG1铰链区

<400>  163

Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        35                  40                  45              


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    50                  55                  60                  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
65                  70                  75                  80  


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                85                  90                  95      


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            100                 105                 110         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        115                 120                 125             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    130                 135                 140                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
145                 150                 155                 160 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                165                 170                 175     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            180                 185                 190         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220 


<210>  164
<211>  217
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  IgG4铰链区

<400>  164

Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215         


<210>  165
<211>  223
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  IgD铰链区

<400>  165

Cys Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala 
1               5                   10                  15      


Val Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val 
            20                  25                  30          


Val Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly 
        35                  40                  45              


Lys Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser 
    50                  55                  60                  


Asn Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu 
65                  70                  75                  80  


Trp Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu 
                85                  90                  95      


Pro Pro Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Gln Ala Pro Val 
            100                 105                 110         


Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala 
        115                 120                 125             


Ser Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu 
    130                 135                 140                 


Leu Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala 
145                 150                 155                 160 


Pro Ala Arg Pro Pro Pro Gln Pro Arg Ser Thr Thr Phe Trp Ala Trp 
                165                 170                 175     


Ser Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr 
            180                 185                 190         


Thr Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser 
        195                 200                 205             


Arg Ser Leu Glu Val Ser Tyr Val Thr Asp His Gly Pro Met Lys 
    210                 215                 220             


<210>  166
<211>  163
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4-1BB铰链区

<400>  166

Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln 
            


<210>  167
<211>  371
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD4铰链区

<400>  167

Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys 
1               5                   10                  15      


Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn 
            20                  25                  30          


Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro 
        35                  40                  45              


Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp Gln 
    50                  55                  60                  


Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp 
65                  70                  75                  80  


Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu 
                85                  90                  95      


Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu Gln Gly Gln 
            100                 105                 110         


Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser Pro Ser Val 
        115                 120                 125             


Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly Lys Thr Leu 
    130                 135                 140                 


Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp Thr Cys Thr 
145                 150                 155                 160 


Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp Ile Val Val 
                165                 170                 175     


Leu Ala Phe Gln Lys Ala Ser Ser Ile Val Tyr Lys Lys Glu Gly Glu 
            180                 185                 190         


Gln Val Glu Phe Ser Phe Pro Leu Ala Phe Thr Val Glu Lys Leu Thr 
        195                 200                 205             


Gly Ser Gly Glu Leu Trp Trp Gln Ala Glu Arg Ala Ser Ser Ser Lys 
    210                 215                 220                 


Ser Trp Ile Thr Phe Asp Leu Lys Asn Lys Glu Val Ser Val Lys Arg 
225                 230                 235                 240 


Val Thr Gln Asp Pro Lys Leu Gln Met Gly Lys Lys Leu Pro Leu His 
                245                 250                 255     


Leu Thr Leu Pro Gln Ala Leu Pro Gln Tyr Ala Gly Ser Gly Asn Leu 
            260                 265                 270         


Thr Leu Ala Leu Glu Ala Lys Thr Gly Lys Leu His Gln Glu Val Asn 
        275                 280                 285             


Leu Val Val Met Arg Ala Thr Gln Leu Gln Lys Asn Leu Thr Cys Glu 
    290                 295                 300                 


Val Trp Gly Pro Thr Ser Pro Lys Leu Met Leu Ser Leu Lys Leu Glu 
305                 310                 315                 320 


Asn Lys Glu Ala Lys Val Ser Lys Arg Glu Lys Ala Val Trp Val Leu 
                325                 330                 335     


Asn Pro Glu Ala Gly Met Trp Gln Cys Leu Leu Ser Asp Ser Gly Gln 
            340                 345                 350         


Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro 
        355                 360                 365             


Val Gln Pro 
    370     


<210>  168
<211>  172
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD27铰链区

<400>  168

Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr Trp Ala Gln 
1               5                   10                  15      


Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe Leu Val Lys 
            20                  25                  30          


Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro Cys Ile Pro 
        35                  40                  45              


Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His Cys Glu Ser 
    50                  55                  60                  


Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys Thr Ile Thr 
65                  70                  75                  80  


Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys Arg Asp Lys 
                85                  90                  95      


Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu Thr Ala Arg 
            100                 105                 110         


Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His Leu Pro Tyr 
        115                 120                 125             


Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met Gln Thr Leu 
    130                 135                 140                 


Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr His Trp Pro 
145                 150                 155                 160 


Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg 
                165                 170         


<210>  169
<211>  155
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD7铰链区

<400>  169

Ala Gln Glu Val Gln Gln Ser Pro His Cys Thr Thr Val Pro Val Gly 
1               5                   10                  15      


Ala Ser Val Asn Ile Thr Cys Ser Thr Ser Gly Gly Leu Arg Gly Ile 
            20                  25                  30          


Tyr Leu Arg Gln Leu Gly Pro Gln Pro Gln Asp Ile Ile Tyr Tyr Glu 
        35                  40                  45              


Asp Gly Val Val Pro Thr Thr Asp Arg Arg Phe Arg Gly Arg Ile Asp 
    50                  55                  60                  


Phe Ser Gly Ser Gln Asp Asn Leu Thr Ile Thr Met His Arg Leu Gln 
65                  70                  75                  80  


Leu Ser Asp Thr Gly Thr Tyr Thr Cys Gln Ala Ile Thr Glu Val Asn 
                85                  90                  95      


Val Tyr Gly Ser Gly Thr Leu Val Leu Val Thr Glu Glu Gln Ser Gln 
            100                 105                 110         


Gly Trp His Arg Cys Ser Asp Ala Pro Pro Arg Ala Ser Ala Leu Pro 
        115                 120                 125             


Ala Pro Pro Thr Gly Ser Ala Leu Pro Asp Pro Gln Thr Ala Ser Ala 
    130                 135                 140                 


Leu Pro Asp Pro Pro Ala Ala Ser Ala Leu Pro 
145                 150                 155 


<210>  170
<211>  161
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD8A铰链区

<400>  170

Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu 
1               5                   10                  15      


Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly 
            20                  25                  30          


Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe 
        35                  40                  45              


Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp 
    50                  55                  60                  


Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr 
65                  70                  75                  80  


Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala 
                85                  90                  95      


Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
            100                 105                 110         


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        115                 120                 125             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    130                 135                 140                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
145                 150                 155                 160 


Asp 
    


<210>  171
<211>  147
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  PD-1铰链区

<400>  171

Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro 
1               5                   10                  15      


Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
            20                  25                  30          


Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser 
        35                  40                  45              


Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser 
    50                  55                  60                  


Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly 
65                  70                  75                  80  


Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly 
                85                  90                  95      


Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys 
            100                 105                 110         


Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 
        115                 120                 125             


Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln 
    130                 135                 140                 


Thr Leu Val 
145         


<210>  172
<211>  120
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  ICOS铰链区

<400>  172

Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile Phe His Asn Gly 
1               5                   10                  15      


Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val Gln Gln Phe Lys 
            20                  25                  30          


Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp Leu Thr Lys Thr 
        35                  40                  45              


Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu Lys Phe Cys His 
    50                  55                  60                  


Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu Tyr Asn Leu Asp 
65                  70                  75                  80  


His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser Ile Phe Asp Pro 
                85                  90                  95      


Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu His Ile Tyr Glu 
            100                 105                 110         


Ser Gln Leu Cys Cys Gln Leu Lys 
        115                 120 


<210>  173
<211>  133
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  OX40铰链区

<400>  173

Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          


Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn 
    50                  55                  60                  


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             


Glu Phe Cys Val Leu 
    130             


<210>  174
<211>  144
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  NKG2D铰链区

<400>  174

Ile Trp Ser Ala Val Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln 
1               5                   10                  15      


Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile 
            20                  25                  30          


Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp 
        35                  40                  45              


Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys 
    50                  55                  60                  


Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr 
65                  70                  75                  80  


His Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp 
                85                  90                  95      


Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met 
            100                 105                 110         


Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile 
        115                 120                 125             


Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 140                 


<210>  175
<211>  138
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  NKG2C铰链区

<400>  175

Ile Pro Phe Leu Glu Gln Asn Asn Ser Ser Pro Asn Thr Arg Thr Gln 
1               5                   10                  15      


Lys Ala Arg His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser 
            20                  25                  30          


Asn Ser Cys Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Ser 
        35                  40                  45              


Leu Leu Ala Cys Thr Ser Lys Asn Ser Ser Leu Leu Ser Ile Asp Asn 
    50                  55                  60                  


Glu Glu Glu Met Lys Phe Leu Ala Ser Ile Leu Pro Ser Ser Trp Ile 
65                  70                  75                  80  


Gly Val Phe Arg Asn Ser Ser His His Pro Trp Val Thr Ile Asn Gly 
                85                  90                  95      


Leu Ala Phe Lys His Lys Ile Lys Asp Ser Asp Asn Ala Glu Leu Asn 
            100                 105                 110         


Cys Ala Val Leu Gln Val Asn Arg Leu Lys Ser Ala Gln Cys Gly Ser 
        115                 120                 125             


Ser Met Ile Tyr His Cys Lys His Lys Leu 
    130                 135             


<210>  176
<211>  5
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  FcεRIγ铰链区

<400>  176

Leu Gly Glu Pro Gln 
1               5   


<210>  177
<211>  127
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  BTLA铰链区

<400>  177

Lys Glu Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His 
1               5                   10                  15      


Ser Ile Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr 
            20                  25                  30          


Cys Ala Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr 
        35                  40                  45              


Cys Val Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn 
    50                  55                  60                  


Ile Ser Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn 
65                  70                  75                  80  


Gly Ser Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser 
                85                  90                  95      


His Ser Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg 
            100                 105                 110         


Pro Ser Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg 
        115                 120                 125         


<210>  178
<211>  137
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  GITR铰链区

<400>  178

Gln Arg Pro Thr Gly Gly Pro Gly Cys Gly Pro Gly Arg Leu Leu Leu 
1               5                   10                  15      


Gly Thr Gly Thr Asp Ala Arg Cys Cys Arg Val His Thr Thr Arg Cys 
            20                  25                  30          


Cys Arg Asp Tyr Pro Gly Glu Glu Cys Cys Ser Glu Trp Asp Cys Met 
        35                  40                  45              


Cys Val Gln Pro Glu Phe His Cys Gly Asp Pro Cys Cys Thr Thr Cys 
    50                  55                  60                  


Arg His His Pro Cys Pro Pro Gly Gln Gly Val Gln Ser Gln Gly Lys 
65                  70                  75                  80  


Phe Ser Phe Gly Phe Gln Cys Ile Asp Cys Ala Ser Gly Thr Phe Ser 
                85                  90                  95      


Gly Gly His Glu Gly His Cys Lys Pro Trp Thr Asp Cys Thr Gln Phe 
            100                 105                 110         


Gly Phe Leu Thr Val Phe Pro Gly Asn Lys Thr His Asn Ala Val Cys 
        115                 120                 125             


Val Pro Gly Ser Pro Pro Ala Glu Pro 
    130                 135         


<210>  179
<211>  30
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  DAP10铰链区

<400>  179

Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly 
1               5                   10                  15      


Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
            20                  25                  30  


<210>  180
<211>  275
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  TIM1铰链区

<400>  180

Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val Thr Leu Pro Cys 
1               5                   10                  15      


His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn Arg Gly Ser Cys 
            20                  25                  30          


Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr Asn Gly Thr His 
        35                  40                  45              


Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu Gly Asp Leu Ser 
    50                  55                  60                  


Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala Val Ser Asp Ser 
65                  70                  75                  80  


Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp Phe Asn Asp Met 
                85                  90                  95      


Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys Val Thr Thr Thr 
            100                 105                 110         


Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val Arg Thr Ser Thr 
        115                 120                 125             


Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr Val Pro Thr Thr 
    130                 135                 140                 


Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr Thr Val Leu Thr 
145                 150                 155                 160 


Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr Thr Thr Ser Ile 
                165                 170                 175     


Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val Ser Thr Phe Val 
            180                 185                 190         


Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro Val Ala Thr Ser 
        195                 200                 205             


Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr Thr Leu Gln Gly 
    210                 215                 220                 


Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr Ser Tyr Thr Thr 
225                 230                 235                 240 


Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly Leu Trp Asn Asn 
                245                 250                 255     


Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu Thr Ala Asn Thr 
            260                 265                 270         


Thr Lys Gly 
        275 


<210>  181
<211>  217
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  SLAM铰链区

<400>  181

Ala Ser Tyr Gly Thr Gly Gly Arg Met Met Asn Cys Pro Lys Ile Leu 
1               5                   10                  15      


Arg Gln Leu Gly Ser Lys Val Leu Leu Pro Leu Thr Tyr Glu Arg Ile 
            20                  25                  30          


Asn Lys Ser Met Asn Lys Ser Ile His Ile Val Val Thr Met Ala Lys 
        35                  40                  45              


Ser Leu Glu Asn Ser Val Glu Asn Lys Ile Val Ser Leu Asp Pro Ser 
    50                  55                  60                  


Glu Ala Gly Pro Pro Arg Tyr Leu Gly Asp Arg Tyr Lys Phe Tyr Leu 
65                  70                  75                  80  


Glu Asn Leu Thr Leu Gly Ile Arg Glu Ser Arg Lys Glu Asp Glu Gly 
                85                  90                  95      


Trp Tyr Leu Met Thr Leu Glu Lys Asn Val Ser Val Gln Arg Phe Cys 
            100                 105                 110         


Leu Gln Leu Arg Leu Tyr Glu Gln Val Ser Thr Pro Glu Ile Lys Val 
        115                 120                 125             


Leu Asn Lys Thr Gln Glu Asn Gly Thr Cys Thr Leu Ile Leu Gly Cys 
    130                 135                 140                 


Thr Val Glu Lys Gly Asp His Val Ala Tyr Ser Trp Ser Glu Lys Ala 
145                 150                 155                 160 


Gly Thr His Pro Leu Asn Pro Ala Asn Ser Ser His Leu Leu Ser Leu 
                165                 170                 175     


Thr Leu Gly Pro Gln His Ala Asp Asn Ile Tyr Ile Cys Thr Val Ser 
            180                 185                 190         


Asn Pro Ile Ser Asn Asn Ser Gln Thr Phe Ser Pro Trp Pro Gly Cys 
        195                 200                 205             


Arg Thr Asp Pro Ser Glu Thr Lys Pro 
    210                 215         


<210>  182
<211>  367
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD30铰链区

<400>  182

Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn Pro Ser 
1               5                   10                  15      


His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys Pro Met 
            20                  25                  30          


Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp Cys Arg 
        35                  40                  45              


Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg Cys Thr 
    50                  55                  60                  


Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro Cys 
65                  70                  75                  80  


Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met Phe Cys 
                85                  90                  95      


Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His Ser Val 
            100                 105                 110         


Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln Lys Asn 
        115                 120                 125             


Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys Ala Ser 
    130                 135                 140                 


Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln Ala Lys 
145                 150                 155                 160 


Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met Pro Val 
                165                 170                 175     


Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu Thr Arg 
            180                 185                 190         


Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp Pro Gly 
        195                 200                 205             


Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys Arg Lys 
    210                 215                 220                 


Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys Thr Ala 
225                 230                 235                 240 


Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro Cys Ala 
                245                 250                 255     


Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile Cys Ala 
            260                 265                 270         


Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro Ile Cys 
        275                 280                 285             


Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys Asp Thr 
    290                 295                 300                 


Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn Pro Thr 
305                 310                 315                 320 


Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln Ser Leu 
                325                 330                 335     


Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr Ser Ala 
            340                 345                 350         


Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala Gly 
        355                 360                 365         


<210>  183
<211>  37
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LIGHT铰链区

<400>  183

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg 
        35          


<210>  184
<211>  21
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD8A信号肽氨基酸序列

<400>  184

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  185
<211>  63
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD8A信号肽核酸序列

<400>  185
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  186
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  TRAC sg9

<400>  186
agagucucuc agcugguaca                                                   20


<210>  187
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  TRAC sg10

<400>  187
ugugcuagac augaggucua                                                   20


<210>  188
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  TRAC sg11

<400>  188
cucucagcug guacacggca                                                   20


<210>  189
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  TRAC sg12

<400>  189
acacggcagg gucaggguuc                                                   20


<210>  190
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  TRAC sg13

<400>  190
agcugguaca cggcaggguc                                                   20


<210>  191
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  TRAC sg14

<400>  191
gagaaucaaa aucggugaau                                                   20


<210>  192
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  TRAC sg15

<400>  192
gacaccuucu uccccagccc                                                   20


<210>  193
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  TRAC sg16

<400>  193
ucucucagcu gguacacggc                                                   20


<210>  194
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  TRAC sg17

<400>  194
gcugguacac ggcaggguca                                                   20


<210>  195
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  TRAC sg18

<400>  195
aaagucagau uuguugcucc                                                   20


<210>  196
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  TRAC sg19

<400>  196
cuggggaaga aggugucuuc                                                   20


<210>  197
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  TRAC sg20

<400>  197
uggauuuaga gucucucagc                                                   20


<210>  198
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  TRAC sg21

<400>  198
agagcaacag ugcuguggcc                                                   20


<210>  199
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  TRAC sg22

<400>  199
cuucaagagc aacagugcug                                                   20


<210>  200
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  TRAC sg23

<400>  200
auuuguuuga gaaucaaaau                                                   20


<210>  201
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg10

<400>  201
cccucguccu gcuacucucg                                                   20


<210>  202
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg2

<400>  202
cguacuggug guacccgcgg                                                   20


<210>  203
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg5

<400>  203
cugaccauga agccacccug                                                   20


<210>  204
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg14

<400>  204
agacucaccg aguggaccug                                                   20


<210>  205
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg21

<400>  205
ggacccuccu gcucuaucca                                                   20


<210>  206
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg23

<400>  206
gauguaaucc uugccgucgu                                                   20


<210>  207
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg26

<400>  207
ccugcgcucu uggaccgcgg                                                   20


<210>  208
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg29

<400>  208
ccucguccug cuacucucgg                                                   20


<210>  209
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg30

<400>  209
aacccucguc cugcuacucu                                                   20


<210>  210
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg31

<400>  210
gaggguucgg ggcgccauga                                                   20


<210>  211
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg32

<400>  211
ccugcuacuc ucgggggcuc                                                   20


<210>  212
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg33

<400>  212
cugguuguag uagccgcgca                                                   20


<210>  213
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg34

<400>  213
uagcccacug cgaugaagcg                                                   20


<210>  214
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg35

<400>  214
guggaccugg ggacccugcg                                                   20


<210>  215
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg36

<400>  215
uggacgacac gcaguucgug                                                   20


<210>  216
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg37

<400>  216
acagacucac cgaguggacc                                                   20


<210>  217
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg38

<400>  217
gcaggagggu ccggaguauu                                                   20


<210>  218
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg39

<400>  218
aguauuggga cggggagaca                                                   20


<210>  219
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg40

<400>  219
cucagaccac caagcacaag                                                   20


<210>  220
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg41

<400>  220
ccgccgcggu ccaagagcgc                                                   20


<210>  221
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg42

<400>  221
cucuuggacc gcggcggaca                                                   20


<210>  222
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A02 sg43

<400>  222
ggauuacauc gcccugaaag                                                   20


<210>  223
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A11 sg8-3

<400>  223
cccccgagag uagcaggagg                                                   20


<210>  224
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A11 sg9-3

<400>  224
aguagcagga ggaggguucg                                                   20


<210>  225
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A11 sg10-3

<400>  225
cccuccuccu gcuacucucg                                                   20


<210>  226
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A11 sg11-3

<400>  226
ccccgagagu agcaggagga                                                   20


<210>  227
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A11 sg14-3

<400>  227
agacugaccg aguggaccug                                                   20


<210>  228
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A11 sg16-3

<400>  228
ggggccggag uauugggacc                                                   20


<210>  229
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A11 sg20-3

<400>  229
ccacucgguc agucugugac                                                   20


<210>  230
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A11 sg21-3

<400>  230
uggauagagc aggaggggcc                                                   20


<210>  231
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A11 sg28-3

<400>  231
ugccgucgua ggcguccugc                                                   20


<210>  232
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A11 Rsg2

<400>  232
cguccugccg guacccgcgg                                                   20


<210>  233
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A11 sg21

<400>  233
ggccccuccu gcucuaucca                                                   20


<210>  234
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A24 sg12-2

<400>  234
ccuggcccug acccagaccu                                                   20


<210>  235
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A24 sg13-2

<400>  235
cccuggcccu gacccagacc                                                   20


<210>  236
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A24 sg14-2

<400>  236
agacugaccg agagaaccug                                                   20


<210>  237
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A24 sg16-2

<400>  237
ggggccggag uauugggacg                                                   20


<210>  238
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A24 sg20-2

<400>  238
ucucucgguc agucugugag                                                   20


<210>  239
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A24 sg21-2

<400>  239
ggccccuccu gcucuaucca                                                   20


<210>  240
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A24 sg22-2

<400>  240
aggcguacug gugguacccg                                                   20


<210>  241
<211>  20
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A24 sg25-2

<400>  241
cugagccgcc auguccgccg                                                   20


<210>  242
<211>  21
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A-homo-551

<400>  242
gcggagcagu ugagagccua c                                                 21


<210>  243
<211>  21
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  HLA-A-homo-NEG

<400>  243
gcucagauca ccaagcgcaa g                                                 21


<210>  244
<211>  21
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  TRAC-homo-375

<400>  244
gaaaguggcc ggguuuaauc u                                                 21


<210>  245
<211>  21
<212>  RNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  TRAC-homo-NEG

<400>  245
gaaacagaua cgaaccuaaa c                                                 21



