﻿                         序列表

<110>  南京圣和药业股份有限公司

<120>  抗CRTAM抗体及其应用

<160>  114

<170>  PatentIn version 3.3

<210>  1
<211>  10
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR1

<400>  1
Gly Tyr Thr Phe Thr Asn Asn Asp Ile Asn 
1               5                   10  

<210>  2
<211>  17
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR2

<400>  2
Trp Ile Tyr Pro Arg Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe Arg 
1               5                   10                  15      
Gly 
    

<210>  3
<211>  5
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR3

<400>  3
Gly Leu Val Asp Tyr 
1               5   

<210>  4
<211>  16
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR1

<400>  4
Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      

<210>  5
<211>  7
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR2

<400>  5
Lys Val Ser Asn Arg Phe Ser 
1               5           

<210>  6
<211>  9
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR3

<400>  6
Ser Gln Ser Thr Arg Val Pro Trp Thr 
1               5                   

<210>  7
<211>  16
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR1

<400>  7
Arg Ser Ser Gln Ser Leu Val His Ser Asn Lys Asn Thr Tyr Leu His 
1               5                   10                  15      

<210>  8
<211>  11
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR1

<400>  8
Gly Tyr Ser Ile Thr Ser Asp Tyr Ala Trp Asn 
1               5                   10      

<210>  9
<211>  16
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR2

<400>  9
Tyr Ile Asn Tyr Ser Gly Thr Thr Ser Tyr Asn Pro Ser Leu Lys Gly 
1               5                   10                  15      

<210>  10
<211>  5
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR3

<400>  10
Arg Phe Leu Asp Tyr 
1               5   

<210>  11
<211>  16
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR2

<400>  11
Tyr Ile Ser Tyr Ser Gly Thr Thr Ser Tyr Asn Pro Ser Leu Lys Gly 
1               5                   10                  15      

<210>  12
<211>  16
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR1

<400>  12
Arg Ser Ser Gln Ser Leu Gly His Ser Asn Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      

<210>  13
<211>  7
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR2

<400>  13
Lys Val Phe Asn Arg Phe Ser 
1               5           

<210>  14
<211>  9
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR3

<400>  14
Ser Gln Ser Thr Arg Val Pro Trp Thr 
1               5                   

<210>  15
<211>  16
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR1

<400>  15
Arg Ser Ser Gln Ser Leu Gly His Ser Asn Lys Asn Thr Tyr Leu Asn 
1               5                   10                  15      

<210>  16
<211>  10
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR1

<400>  16
Gly Phe Thr Phe Ser Thr Ser Ala Met Ser 
1               5                   10  

<210>  17
<211>  17
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR2

<400>  17
Thr Ile Ser Ser Gly Gly Asp Tyr Thr Tyr Tyr Ser Asp Asn Val Lys 
1               5                   10                  15      
Gly 
    

<210>  18
<211>  7
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR3

<400>  18
Gly Tyr Asp Glu Ala Asp Tyr 
1               5           

<210>  19
<211>  11
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR1

<400>  19
Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      

<210>  20
<211>  7
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR2

<400>  20
Tyr Thr Ser Arg Leu His Ser 
1               5           

<210>  21
<211>  9
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR3

<400>  21
Gln Gln Gly Asp Thr Phe Pro Trp Thr 
1               5                   

<210>  22
<211>  10
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR1

<400>  22
Gly Tyr Ser Phe Ser Asn Tyr Trp Ile Glu 
1               5                   10  

<210>  23
<211>  17
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR2

<400>  23
Glu Ile Leu Pro Gly Val Pro Thr Ile Tyr Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      
Asp 
    

<210>  24
<211>  6
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR3

<400>  24
Asp Pro Trp Phe Ala Tyr 
1               5       

<210>  25
<211>  17
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR2

<400>  25
Glu Ile Leu Pro Gly Val Pro Thr Ile Tyr Tyr Asn Ala Lys Phe Lys 
1               5                   10                  15      
Asp 
    

<210>  26
<211>  11
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR1

<400>  26
Arg Ala Ser Gln Ser Ile Gly Thr Ser Leu His 
1               5                   10      

<210>  27
<211>  7
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR2

<400>  27
Tyr Ala Ser Gln Ser Ile Ser 
1               5           

<210>  28
<211>  9
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR3

<400>  28
Gln Gln Ser Asn Asn Trp Pro Phe Thr 
1               5                   

<210>  29
<211>  393
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  human-CRTAM

<400>  29
Met Trp Trp Arg Val Leu Ser Leu Leu Ala Trp Phe Pro Leu Gln Glu 
1               5                   10                  15      
Ala Ser Leu Thr Asn His Thr Glu Thr Ile Thr Val Glu Glu Gly Gln 
            20                  25                  30          
Thr Leu Thr Leu Lys Cys Val Thr Ser Leu Arg Lys Asn Ser Ser Leu 
        35                  40                  45              
Gln Trp Leu Thr Pro Ser Gly Phe Thr Ile Phe Leu Asn Glu Tyr Pro 
    50                  55                  60                  
Ala Leu Lys Asn Ser Lys Tyr Gln Leu Leu His His Ser Ala Asn Gln 
65                  70                  75                  80  
Leu Ser Ile Thr Val Pro Asn Val Thr Leu Gln Asp Glu Gly Val Tyr 
                85                  90                  95      
Lys Cys Leu His Tyr Ser Asp Ser Val Ser Thr Lys Glu Val Lys Val 
            100                 105                 110         
Ile Val Leu Ala Thr Pro Phe Lys Pro Ile Leu Glu Ala Ser Val Ile 
        115                 120                 125             
Arg Lys Gln Asn Gly Glu Glu His Val Val Leu Met Cys Ser Thr Met 
    130                 135                 140                 
Arg Ser Lys Pro Pro Pro Gln Ile Thr Trp Leu Leu Gly Asn Ser Met 
145                 150                 155                 160 
Glu Val Ser Gly Gly Thr Leu His Glu Phe Glu Thr Asp Gly Lys Lys 
                165                 170                 175     
Cys Asn Thr Thr Ser Thr Leu Ile Ile His Thr Tyr Gly Lys Asn Ser 
            180                 185                 190         
Thr Val Asp Cys Ile Ile Arg His Arg Gly Leu Gln Gly Arg Lys Leu 
        195                 200                 205             
Val Ala Pro Phe Arg Phe Glu Asp Leu Val Thr Asp Glu Glu Thr Ala 
    210                 215                 220                 
Ser Asp Ala Leu Glu Arg Asn Ser Leu Ser Ser Gln Asp Pro Gln Gln 
225                 230                 235                 240 
Pro Thr Ser Thr Val Ser Val Thr Glu Asp Ser Ser Thr Ser Glu Ile 
                245                 250                 255     
Asp Lys Glu Glu Lys Glu Gln Thr Thr Gln Asp Pro Asp Leu Thr Thr 
            260                 265                 270         
Glu Ala Asn Pro Gln Tyr Leu Gly Leu Ala Arg Lys Lys Ser Gly Ile 
        275                 280                 285             
Leu Leu Leu Thr Leu Val Ser Phe Leu Ile Phe Ile Leu Phe Ile Ile 
    290                 295                 300                 
Val Gln Leu Phe Ile Met Lys Leu Arg Lys Ala His Val Ile Trp Lys 
305                 310                 315                 320 
Lys Glu Asn Glu Val Ser Glu His Thr Leu Glu Ser Tyr Arg Ser Arg 
                325                 330                 335     
Ser Asn Asn Glu Glu Thr Ser Ser Glu Glu Lys Asn Gly Gln Ser Ser 
            340                 345                 350         
His Pro Met Arg Cys Met Asn Tyr Ile Thr Lys Leu Tyr Ser Glu Ala 
        355                 360                 365             
Lys Thr Lys Arg Lys Glu Asn Val Gln His Ser Lys Leu Glu Glu Lys 
    370                 375                 380                 
His Ile Gln Val Pro Glu Ser Ile Val 
385                 390             

<210>  30
<211>  522
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  human-CRTAM-ECD-mFc

<400>  30
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Leu Thr Asn His Thr Glu Thr Ile Thr Val Glu Glu 
            20                  25                  30          
Gly Gln Thr Leu Thr Leu Lys Cys Val Thr Ser Leu Arg Lys Asn Ser 
        35                  40                  45              
Ser Leu Gln Trp Leu Thr Pro Ser Gly Phe Thr Ile Phe Leu Asn Glu 
    50                  55                  60                  
Tyr Pro Ala Leu Lys Asn Ser Lys Tyr Gln Leu Leu His His Ser Ala 
65                  70                  75                  80  
Asn Gln Leu Ser Ile Thr Val Pro Asn Val Thr Leu Gln Asp Glu Gly 
                85                  90                  95      
Val Tyr Lys Cys Leu His Tyr Ser Asp Ser Val Ser Thr Lys Glu Val 
            100                 105                 110         
Lys Val Ile Val Leu Ala Thr Pro Phe Lys Pro Ile Leu Glu Ala Ser 
        115                 120                 125             
Val Ile Arg Lys Gln Asn Gly Glu Glu His Val Val Leu Met Cys Ser 
    130                 135                 140                 
Thr Met Arg Ser Lys Pro Pro Pro Gln Ile Thr Trp Leu Leu Gly Asn 
145                 150                 155                 160 
Ser Met Glu Val Ser Gly Gly Thr Leu His Glu Phe Glu Thr Asp Gly 
                165                 170                 175     
Lys Lys Cys Asn Thr Thr Ser Thr Leu Ile Ile His Thr Tyr Gly Lys 
            180                 185                 190         
Asn Ser Thr Val Asp Cys Ile Ile Arg His Arg Gly Leu Gln Gly Arg 
        195                 200                 205             
Lys Leu Val Ala Pro Phe Arg Phe Glu Asp Leu Val Thr Asp Glu Glu 
    210                 215                 220                 
Thr Ala Ser Asp Ala Leu Glu Arg Asn Ser Leu Ser Ser Gln Asp Pro 
225                 230                 235                 240 
Gln Gln Pro Thr Ser Thr Val Ser Val Thr Glu Asp Ser Ser Thr Ser 
                245                 250                 255     
Glu Ile Asp Lys Glu Glu Lys Glu Gln Thr Thr Gln Asp Pro Asp Leu 
            260                 265                 270         
Thr Thr Glu Ala Asn Pro Gln Tyr Leu Gly Leu Ala Arg Lys Lys Ser 
        275                 280                 285             
Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
    290                 295                 300                 
Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
305                 310                 315                 320 
Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
                325                 330                 335     
Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
            340                 345                 350         
Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
        355                 360                 365             
Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
    370                 375                 380                 
His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
385                 390                 395                 400 
Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
                405                 410                 415     
Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
            420                 425                 430         
Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
        435                 440                 445             
Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
    450                 455                 460                 
Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
465                 470                 475                 480 
Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
                485                 490                 495     
Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
            500                 505                 510         
Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        515                 520         

<210>  31
<211>  521
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  human-CRTAM-ECD-hFc

<400>  31
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Leu Thr Asn His Thr Glu Thr Ile Thr Val Glu Glu 
            20                  25                  30          
Gly Gln Thr Leu Thr Leu Lys Cys Val Thr Ser Leu Arg Lys Asn Ser 
        35                  40                  45              
Ser Leu Gln Trp Leu Thr Pro Ser Gly Phe Thr Ile Phe Leu Asn Glu 
    50                  55                  60                  
Tyr Pro Ala Leu Lys Asn Ser Lys Tyr Gln Leu Leu His His Ser Ala 
65                  70                  75                  80  
Asn Gln Leu Ser Ile Thr Val Pro Asn Val Thr Leu Gln Asp Glu Gly 
                85                  90                  95      
Val Tyr Lys Cys Leu His Tyr Ser Asp Ser Val Ser Thr Lys Glu Val 
            100                 105                 110         
Lys Val Ile Val Leu Ala Thr Pro Phe Lys Pro Ile Leu Glu Ala Ser 
        115                 120                 125             
Val Ile Arg Lys Gln Asn Gly Glu Glu His Val Val Leu Met Cys Ser 
    130                 135                 140                 
Thr Met Arg Ser Lys Pro Pro Pro Gln Ile Thr Trp Leu Leu Gly Asn 
145                 150                 155                 160 
Ser Met Glu Val Ser Gly Gly Thr Leu His Glu Phe Glu Thr Asp Gly 
                165                 170                 175     
Lys Lys Cys Asn Thr Thr Ser Thr Leu Ile Ile His Thr Tyr Gly Lys 
            180                 185                 190         
Asn Ser Thr Val Asp Cys Ile Ile Arg His Arg Gly Leu Gln Gly Arg 
        195                 200                 205             
Lys Leu Val Ala Pro Phe Arg Phe Glu Asp Leu Val Thr Asp Glu Glu 
    210                 215                 220                 
Thr Ala Ser Asp Ala Leu Glu Arg Asn Ser Leu Ser Ser Gln Asp Pro 
225                 230                 235                 240 
Gln Gln Pro Thr Ser Thr Val Ser Val Thr Glu Asp Ser Ser Thr Ser 
                245                 250                 255     
Glu Ile Asp Lys Glu Glu Lys Glu Gln Thr Thr Gln Asp Pro Asp Leu 
            260                 265                 270         
Thr Thr Glu Ala Asn Pro Gln Tyr Leu Gly Leu Ala Arg Lys Lys Ser 
        275                 280                 285             
Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    290                 295                 300                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
305                 310                 315                 320 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                325                 330                 335     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            340                 345                 350         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        355                 360                 365             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    370                 375                 380                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
385                 390                 395                 400 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                405                 410                 415     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            420                 425                 430         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        435                 440                 445             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    450                 455                 460                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
465                 470                 475                 480 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                485                 490                 495     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            500                 505                 510         
Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520     

<210>  32
<211>  307
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  human-CRTAM-ECD-Myc-10His

<400>  32
Met Trp Trp Arg Val Leu Ser Leu Leu Ala Trp Phe Pro Leu Gln Glu 
1               5                   10                  15      
Ala Ser Leu Thr Asn His Thr Glu Thr Ile Thr Val Glu Glu Gly Gln 
            20                  25                  30          
Thr Leu Thr Leu Lys Cys Val Thr Ser Leu Arg Lys Asn Ser Ser Leu 
        35                  40                  45              
Gln Trp Leu Thr Pro Ser Gly Phe Thr Ile Phe Leu Asn Glu Tyr Pro 
    50                  55                  60                  
Ala Leu Lys Asn Ser Lys Tyr Gln Leu Leu His His Ser Ala Asn Gln 
65                  70                  75                  80  
Leu Ser Ile Thr Val Pro Asn Val Thr Leu Gln Asp Glu Gly Val Tyr 
                85                  90                  95      
Lys Cys Leu His Tyr Ser Asp Ser Val Ser Thr Lys Glu Val Lys Val 
            100                 105                 110         
Ile Val Leu Ala Thr Pro Phe Lys Pro Ile Leu Glu Ala Ser Val Ile 
        115                 120                 125             
Arg Lys Gln Asn Gly Glu Glu His Val Val Leu Met Cys Ser Thr Met 
    130                 135                 140                 
Arg Ser Lys Pro Pro Pro Gln Ile Thr Trp Leu Leu Gly Asn Ser Met 
145                 150                 155                 160 
Glu Val Ser Gly Gly Thr Leu His Glu Phe Glu Thr Asp Gly Lys Lys 
                165                 170                 175     
Cys Asn Thr Thr Ser Thr Leu Ile Ile His Thr Tyr Gly Lys Asn Ser 
            180                 185                 190         
Thr Val Asp Cys Ile Ile Arg His Arg Gly Leu Gln Gly Arg Lys Leu 
        195                 200                 205             
Val Ala Pro Phe Arg Phe Glu Asp Leu Val Thr Asp Glu Glu Thr Ala 
    210                 215                 220                 
Ser Asp Ala Leu Glu Arg Asn Ser Leu Ser Ser Gln Asp Pro Gln Gln 
225                 230                 235                 240 
Pro Thr Ser Thr Val Ser Val Thr Glu Asp Ser Ser Thr Ser Glu Ile 
                245                 250                 255     
Asp Lys Glu Glu Lys Glu Gln Thr Thr Gln Asp Pro Asp Leu Thr Thr 
            260                 265                 270         
Glu Ala Asn Pro Gln Tyr Leu Gly Leu Ala Arg Lys Lys Ser Gly Glu 
        275                 280                 285             
Gln Lys Leu Ile Ser Glu Glu Asp Leu His His His His His His His 
    290                 295                 300                 
His His His 
305         

<210>  33
<211>  393
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  cyno-CRTAM

<400>  33
Met Trp Trp Gly Val Phe Ser Leu Leu Ala Trp Phe Pro Leu Gln Glu 
1               5                   10                  15      
Ala Ser Leu Thr Asn His Thr Glu Thr Ile Thr Val Glu Glu Gly Gln 
            20                  25                  30          
Thr Leu Thr Leu Lys Cys Val Thr Ser Leu Arg Lys Ser Ser Ser Leu 
        35                  40                  45              
Gln Trp Leu Thr Pro Ser Gly Phe Thr Ile Phe Leu Asn Glu Tyr Pro 
    50                  55                  60                  
Ala Phe Lys Asn Ser Arg Tyr Gln Leu Leu His His Ser Ala Asn Gln 
65                  70                  75                  80  
Leu Ser Ile Ser Val Ser Asn Ile Thr Leu Gln Asp Glu Gly Val Tyr 
                85                  90                  95      
Lys Cys Leu His Tyr Ser Asp Ser Val Ser Thr Lys Glu Val Lys Val 
            100                 105                 110         
Ile Val Leu Ala Thr Pro Phe Lys Pro Ile Leu Glu Ala Ser Val Ile 
        115                 120                 125             
Arg Lys Gln Asn Gly Glu Glu His Val Val Leu Met Cys Ser Ala Met 
    130                 135                 140                 
Arg Ser Lys Pro Pro Pro Gln Ile Thr Trp Leu Leu Gly Asn Gly Val 
145                 150                 155                 160 
Glu Val Ser Gly Gly Thr His His Glu Phe Glu Thr Asp Gly Lys Lys 
                165                 170                 175     
Cys Asn Thr Thr Ser Thr Leu Ile Ile His Thr Tyr Gly Lys Asn Ser 
            180                 185                 190         
Thr Val Asp Cys Ile Ile Arg His Arg Gly Leu Gln Gly Arg Lys Leu 
        195                 200                 205             
Val Ala Pro Phe Arg Phe Glu Asp Leu Val Thr Asp Glu Glu Thr Ala 
    210                 215                 220                 
Ser Asp Ala Leu Glu Arg Asn Ser Val Ser Ser Gln Asp Pro Gln Gln 
225                 230                 235                 240 
Pro Thr Ser Thr Val Ser Val Met Glu Asp Ser Ser Thr Leu Glu Ile 
                245                 250                 255     
Asp Lys Glu Glu Lys Glu Gln Thr Thr Gln Asp Pro Asp Leu Thr Thr 
            260                 265                 270         
Lys Ala Asn Pro Gln Tyr Leu Gly Leu Ala Arg Lys Lys Ser Gly Ile 
        275                 280                 285             
Leu Leu Leu Thr Leu Val Ser Phe Leu Ile Phe Ile Leu Phe Ile Ile 
    290                 295                 300                 
Val Gln Leu Phe Ile Met Lys Leu Arg Lys Ala His Val Ile Trp Lys 
305                 310                 315                 320 
Lys Glu Asn Glu Val Ser Glu His Thr Leu Glu Ser Tyr Arg Ser Arg 
                325                 330                 335     
Ser Asn Asn Glu Glu Thr Ser Ser Gln Glu Lys Asn Gly Gln Ser Ser 
            340                 345                 350         
His Pro Val Arg Cys Met Asn Tyr Ile Thr Lys Leu Tyr Ser Glu Ala 
        355                 360                 365             
Lys Thr Lys Arg Lys Glu Asn Val Gln His Ser Lys Leu Asn Glu Lys 
    370                 375                 380                 
His Thr Gln Val Pro Glu Thr Ile Val 
385                 390             

<210>  34
<211>  522
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  cyno-CRTAM-ECD-mFc

<400>  34
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Leu Thr Asn His Thr Glu Thr Ile Thr Val Glu Glu 
            20                  25                  30          
Gly Gln Thr Leu Thr Leu Lys Cys Val Thr Ser Leu Arg Lys Ser Ser 
        35                  40                  45              
Ser Leu Gln Trp Leu Thr Pro Ser Gly Phe Thr Ile Phe Leu Asn Glu 
    50                  55                  60                  
Tyr Pro Ala Phe Lys Asn Ser Arg Tyr Gln Leu Leu His His Ser Ala 
65                  70                  75                  80  
Asn Gln Leu Ser Ile Ser Val Ser Asn Ile Thr Leu Gln Asp Glu Gly 
                85                  90                  95      
Val Tyr Lys Cys Leu His Tyr Ser Asp Ser Val Ser Thr Lys Glu Val 
            100                 105                 110         
Lys Val Ile Val Leu Ala Thr Pro Phe Lys Pro Ile Leu Glu Ala Ser 
        115                 120                 125             
Val Ile Arg Lys Gln Asn Gly Glu Glu His Val Val Leu Met Cys Ser 
    130                 135                 140                 
Ala Met Arg Ser Lys Pro Pro Pro Gln Ile Thr Trp Leu Leu Gly Asn 
145                 150                 155                 160 
Gly Val Glu Val Ser Gly Gly Thr His His Glu Phe Glu Thr Asp Gly 
                165                 170                 175     
Lys Lys Cys Asn Thr Thr Ser Thr Leu Ile Ile His Thr Tyr Gly Lys 
            180                 185                 190         
Asn Ser Thr Val Asp Cys Ile Ile Arg His Arg Gly Leu Gln Gly Arg 
        195                 200                 205             
Lys Leu Val Ala Pro Phe Arg Phe Glu Asp Leu Val Thr Asp Glu Glu 
    210                 215                 220                 
Thr Ala Ser Asp Ala Leu Glu Arg Asn Ser Val Ser Ser Gln Asp Pro 
225                 230                 235                 240 
Gln Gln Pro Thr Ser Thr Val Ser Val Met Glu Asp Ser Ser Thr Leu 
                245                 250                 255     
Glu Ile Asp Lys Glu Glu Lys Glu Gln Thr Thr Gln Asp Pro Asp Leu 
            260                 265                 270         
Thr Thr Lys Ala Asn Pro Gln Tyr Leu Gly Leu Ala Arg Lys Lys Ser 
        275                 280                 285             
Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
    290                 295                 300                 
Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
305                 310                 315                 320 
Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
                325                 330                 335     
Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
            340                 345                 350         
Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
        355                 360                 365             
Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
    370                 375                 380                 
His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
385                 390                 395                 400 
Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
                405                 410                 415     
Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
            420                 425                 430         
Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
        435                 440                 445             
Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
    450                 455                 460                 
Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
465                 470                 475                 480 
Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
                485                 490                 495     
Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
            500                 505                 510         
Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        515                 520         

<210>  35
<211>  521
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  cyno-CRTAM-ECD-hFc

<400>  35
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Leu Thr Asn His Thr Glu Thr Ile Thr Val Glu Glu 
            20                  25                  30          
Gly Gln Thr Leu Thr Leu Lys Cys Val Thr Ser Leu Arg Lys Ser Ser 
        35                  40                  45              
Ser Leu Gln Trp Leu Thr Pro Ser Gly Phe Thr Ile Phe Leu Asn Glu 
    50                  55                  60                  
Tyr Pro Ala Phe Lys Asn Ser Arg Tyr Gln Leu Leu His His Ser Ala 
65                  70                  75                  80  
Asn Gln Leu Ser Ile Ser Val Ser Asn Ile Thr Leu Gln Asp Glu Gly 
                85                  90                  95      
Val Tyr Lys Cys Leu His Tyr Ser Asp Ser Val Ser Thr Lys Glu Val 
            100                 105                 110         
Lys Val Ile Val Leu Ala Thr Pro Phe Lys Pro Ile Leu Glu Ala Ser 
        115                 120                 125             
Val Ile Arg Lys Gln Asn Gly Glu Glu His Val Val Leu Met Cys Ser 
    130                 135                 140                 
Ala Met Arg Ser Lys Pro Pro Pro Gln Ile Thr Trp Leu Leu Gly Asn 
145                 150                 155                 160 
Gly Val Glu Val Ser Gly Gly Thr His His Glu Phe Glu Thr Asp Gly 
                165                 170                 175     
Lys Lys Cys Asn Thr Thr Ser Thr Leu Ile Ile His Thr Tyr Gly Lys 
            180                 185                 190         
Asn Ser Thr Val Asp Cys Ile Ile Arg His Arg Gly Leu Gln Gly Arg 
        195                 200                 205             
Lys Leu Val Ala Pro Phe Arg Phe Glu Asp Leu Val Thr Asp Glu Glu 
    210                 215                 220                 
Thr Ala Ser Asp Ala Leu Glu Arg Asn Ser Val Ser Ser Gln Asp Pro 
225                 230                 235                 240 
Gln Gln Pro Thr Ser Thr Val Ser Val Met Glu Asp Ser Ser Thr Leu 
                245                 250                 255     
Glu Ile Asp Lys Glu Glu Lys Glu Gln Thr Thr Gln Asp Pro Asp Leu 
            260                 265                 270         
Thr Thr Lys Ala Asn Pro Gln Tyr Leu Gly Leu Ala Arg Lys Lys Ser 
        275                 280                 285             
Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    290                 295                 300                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
305                 310                 315                 320 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                325                 330                 335     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            340                 345                 350         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        355                 360                 365             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    370                 375                 380                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
385                 390                 395                 400 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                405                 410                 415     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            420                 425                 430         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        435                 440                 445             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    450                 455                 460                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
465                 470                 475                 480 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                485                 490                 495     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            500                 505                 510         
Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520     

<210>  36
<211>  307
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  cyno-CRTAM-ECD-Myc-10His

<400>  36
Met Trp Trp Gly Val Phe Ser Leu Leu Ala Trp Phe Pro Leu Gln Glu 
1               5                   10                  15      
Ala Ser Leu Thr Asn His Thr Glu Thr Ile Thr Val Glu Glu Gly Gln 
            20                  25                  30          
Thr Leu Thr Leu Lys Cys Val Thr Ser Leu Arg Lys Ser Ser Ser Leu 
        35                  40                  45              
Gln Trp Leu Thr Pro Ser Gly Phe Thr Ile Phe Leu Asn Glu Tyr Pro 
    50                  55                  60                  
Ala Phe Lys Asn Ser Arg Tyr Gln Leu Leu His His Ser Ala Asn Gln 
65                  70                  75                  80  
Leu Ser Ile Ser Val Ser Asn Ile Thr Leu Gln Asp Glu Gly Val Tyr 
                85                  90                  95      
Lys Cys Leu His Tyr Ser Asp Ser Val Ser Thr Lys Glu Val Lys Val 
            100                 105                 110         
Ile Val Leu Ala Thr Pro Phe Lys Pro Ile Leu Glu Ala Ser Val Ile 
        115                 120                 125             
Arg Lys Gln Asn Gly Glu Glu His Val Val Leu Met Cys Ser Ala Met 
    130                 135                 140                 
Arg Ser Lys Pro Pro Pro Gln Ile Thr Trp Leu Leu Gly Asn Gly Val 
145                 150                 155                 160 
Glu Val Ser Gly Gly Thr His His Glu Phe Glu Thr Asp Gly Lys Lys 
                165                 170                 175     
Cys Asn Thr Thr Ser Thr Leu Ile Ile His Thr Tyr Gly Lys Asn Ser 
            180                 185                 190         
Thr Val Asp Cys Ile Ile Arg His Arg Gly Leu Gln Gly Arg Lys Leu 
        195                 200                 205             
Val Ala Pro Phe Arg Phe Glu Asp Leu Val Thr Asp Glu Glu Thr Ala 
    210                 215                 220                 
Ser Asp Ala Leu Glu Arg Asn Ser Val Ser Ser Gln Asp Pro Gln Gln 
225                 230                 235                 240 
Pro Thr Ser Thr Val Ser Val Met Glu Asp Ser Ser Thr Leu Glu Ile 
                245                 250                 255     
Asp Lys Glu Glu Lys Glu Gln Thr Thr Gln Asp Pro Asp Leu Thr Thr 
            260                 265                 270         
Lys Ala Asn Pro Gln Tyr Leu Gly Leu Ala Arg Lys Lys Ser Gly Glu 
        275                 280                 285             
Gln Lys Leu Ile Ser Glu Glu Asp Leu His His His His His His His 
    290                 295                 300                 
His His His 
305         

<210>  37
<211>  525
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  mouse-CRTAM-ECD-mFc

<400>  37
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ala Phe Leu Lys Met Glu Thr Val Thr Val Glu Glu Gly 
            20                  25                  30          
Gln Thr Leu Thr Leu Thr Cys Val Thr Ser Gln Thr Lys Asn Val Ser 
        35                  40                  45              
Leu Gln Trp Leu Ala Pro Ser Gly Phe Thr Ile Phe Leu Asn Gln His 
    50                  55                  60                  
Pro Ala Leu Lys Ser Ser Lys Tyr Gln Leu Leu His His Ser Ala Thr 
65                  70                  75                  80  
Gln Leu Ser Ile Ser Val Ser Asn Val Thr Leu Arg Glu Glu Gly Val 
                85                  90                  95      
Tyr Thr Cys Leu His Tyr Gly Ser Ser Val Lys Thr Lys Gln Val Arg 
            100                 105                 110         
Val Thr Val Leu Val Thr Pro Phe Gln Pro Thr Val Glu Ala Leu Val 
        115                 120                 125             
Leu Arg Arg Gln Asn Gly Glu Lys Ser Val Val Leu Lys Cys Ser Thr 
    130                 135                 140                 
Glu Arg Ser Lys Pro Pro Pro Gln Ile Thr Trp Leu Leu Gly Glu Gly 
145                 150                 155                 160 
Leu Glu Ile Tyr Gly Glu Leu Asn His Glu Phe Glu Ala Asp Gly Lys 
                165                 170                 175     
Ile Cys Asn Thr Ser Ser Met Leu Ile Ala Arg Ala Tyr Gly Lys Asn 
            180                 185                 190         
Ser Thr Val His Cys Ile Ile Gln His Glu Gly Leu His Gly Arg Lys 
        195                 200                 205             
Leu Val Ala Pro Phe Gln Phe Glu Asp Leu Val Ala Asp Gln Glu Thr 
    210                 215                 220                 
Ser Asp Gln Glu Thr Ser Asp Ala Pro Glu Gln Ser Ser Leu Ser Ser 
225                 230                 235                 240 
Gln Ala Leu Gln Gln Pro Thr Ser Thr Val Ser Met Met Glu Asn Ser 
                245                 250                 255     
Ser Ile Pro Glu Thr Asp Lys Glu Glu Lys Glu His Ala Thr Gln Asp 
            260                 265                 270         
Pro Gly Leu Ser Thr Glu Ala Ser Ala Gln His Thr Gly Leu Ala Arg 
        275                 280                 285             
Arg Lys Ser Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro 
    290                 295                 300                 
Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile 
305                 310                 315                 320 
Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile 
                325                 330                 335     
Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln 
            340                 345                 350         
Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln 
        355                 360                 365             
Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu 
    370                 375                 380                 
Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys 
385                 390                 395                 400 
Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys 
                405                 410                 415     
Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro 
            420                 425                 430         
Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr 
        435                 440                 445             
Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys 
    450                 455                 460                 
Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 
Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val 
                485                 490                 495     
Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn 
            500                 505                 510         
His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        515                 520                 525 

<210>  38
<211>  524
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  mouse-CRTAM-ECD-hFc

<400>  38
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ala Phe Leu Lys Met Glu Thr Val Thr Val Glu Glu Gly 
            20                  25                  30          
Gln Thr Leu Thr Leu Thr Cys Val Thr Ser Gln Thr Lys Asn Val Ser 
        35                  40                  45              
Leu Gln Trp Leu Ala Pro Ser Gly Phe Thr Ile Phe Leu Asn Gln His 
    50                  55                  60                  
Pro Ala Leu Lys Ser Ser Lys Tyr Gln Leu Leu His His Ser Ala Thr 
65                  70                  75                  80  
Gln Leu Ser Ile Ser Val Ser Asn Val Thr Leu Arg Glu Glu Gly Val 
                85                  90                  95      
Tyr Thr Cys Leu His Tyr Gly Ser Ser Val Lys Thr Lys Gln Val Arg 
            100                 105                 110         
Val Thr Val Leu Val Thr Pro Phe Gln Pro Thr Val Glu Ala Leu Val 
        115                 120                 125             
Leu Arg Arg Gln Asn Gly Glu Lys Ser Val Val Leu Lys Cys Ser Thr 
    130                 135                 140                 
Glu Arg Ser Lys Pro Pro Pro Gln Ile Thr Trp Leu Leu Gly Glu Gly 
145                 150                 155                 160 
Leu Glu Ile Tyr Gly Glu Leu Asn His Glu Phe Glu Ala Asp Gly Lys 
                165                 170                 175     
Ile Cys Asn Thr Ser Ser Met Leu Ile Ala Arg Ala Tyr Gly Lys Asn 
            180                 185                 190         
Ser Thr Val His Cys Ile Ile Gln His Glu Gly Leu His Gly Arg Lys 
        195                 200                 205             
Leu Val Ala Pro Phe Gln Phe Glu Asp Leu Val Ala Asp Gln Glu Thr 
    210                 215                 220                 
Ser Asp Gln Glu Thr Ser Asp Ala Pro Glu Gln Ser Ser Leu Ser Ser 
225                 230                 235                 240 
Gln Ala Leu Gln Gln Pro Thr Ser Thr Val Ser Met Met Glu Asn Ser 
                245                 250                 255     
Ser Ile Pro Glu Thr Asp Lys Glu Glu Lys Glu His Ala Thr Gln Asp 
            260                 265                 270         
Pro Gly Leu Ser Thr Glu Ala Ser Ala Gln His Thr Gly Leu Ala Arg 
        275                 280                 285             
Arg Lys Ser Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
    290                 295                 300                 
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
305                 310                 315                 320 
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                325                 330                 335     
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            340                 345                 350         
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        355                 360                 365             
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    370                 375                 380                 
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
385                 390                 395                 400 
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                405                 410                 415     
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            420                 425                 430         
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        435                 440                 445             
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    450                 455                 460                 
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
465                 470                 475                 480 
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                485                 490                 495     
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            500                 505                 510         
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520                 

<210>  39
<211>  309
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  mouse-CRTAM-ECD-Myc-10His

<400>  39
Met Trp Trp Gly Ala Leu Ser Leu Leu Phe Trp Val Pro Val Gln Ala 
1               5                   10                  15      
Ala Phe Leu Lys Met Glu Thr Val Thr Val Glu Glu Gly Gln Thr Leu 
            20                  25                  30          
Thr Leu Thr Cys Val Thr Ser Gln Thr Lys Asn Val Ser Leu Gln Trp 
        35                  40                  45              
Leu Ala Pro Ser Gly Phe Thr Ile Phe Leu Asn Gln His Pro Ala Leu 
    50                  55                  60                  
Lys Ser Ser Lys Tyr Gln Leu Leu His His Ser Ala Thr Gln Leu Ser 
65                  70                  75                  80  
Ile Ser Val Ser Asn Val Thr Leu Arg Glu Glu Gly Val Tyr Thr Cys 
                85                  90                  95      
Leu His Tyr Gly Ser Ser Val Lys Thr Lys Gln Val Arg Val Thr Val 
            100                 105                 110         
Leu Val Thr Pro Phe Gln Pro Thr Val Glu Ala Leu Val Leu Arg Arg 
        115                 120                 125             
Gln Asn Gly Glu Lys Ser Val Val Leu Lys Cys Ser Thr Glu Arg Ser 
    130                 135                 140                 
Lys Pro Pro Pro Gln Ile Thr Trp Leu Leu Gly Glu Gly Leu Glu Ile 
145                 150                 155                 160 
Tyr Gly Glu Leu Asn His Glu Phe Glu Ala Asp Gly Lys Ile Cys Asn 
                165                 170                 175     
Thr Ser Ser Met Leu Ile Ala Arg Ala Tyr Gly Lys Asn Ser Thr Val 
            180                 185                 190         
His Cys Ile Ile Gln His Glu Gly Leu His Gly Arg Lys Leu Val Ala 
        195                 200                 205             
Pro Phe Gln Phe Glu Asp Leu Val Ala Asp Gln Glu Thr Ser Asp Gln 
    210                 215                 220                 
Glu Thr Ser Asp Ala Pro Glu Gln Ser Ser Leu Ser Ser Gln Ala Leu 
225                 230                 235                 240 
Gln Gln Pro Thr Ser Thr Val Ser Met Met Glu Asn Ser Ser Ile Pro 
                245                 250                 255     
Glu Thr Asp Lys Glu Glu Lys Glu His Ala Thr Gln Asp Pro Gly Leu 
            260                 265                 270         
Ser Thr Glu Ala Ser Ala Gln His Thr Gly Leu Ala Arg Arg Lys Ser 
        275                 280                 285             
Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu His His His His His 
    290                 295                 300                 
His His His His His 
305                 

<210>  40
<211>  582
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  human-CADM1-ECD-mFc

<400>  40
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Gln Asn Leu Phe Thr Lys Asp Val Thr Val Ile Glu Gly 
            20                  25                  30          
Glu Val Ala Thr Ile Ser Cys Gln Val Asn Lys Ser Asp Asp Ser Val 
        35                  40                  45              
Ile Gln Leu Leu Asn Pro Asn Arg Gln Thr Ile Tyr Phe Arg Asp Phe 
    50                  55                  60                  
Arg Pro Leu Lys Asp Ser Arg Phe Gln Leu Leu Asn Phe Ser Ser Ser 
65                  70                  75                  80  
Glu Leu Lys Val Ser Leu Thr Asn Val Ser Ile Ser Asp Glu Gly Arg 
                85                  90                  95      
Tyr Phe Cys Gln Leu Tyr Thr Asp Pro Pro Gln Glu Ser Tyr Thr Thr 
            100                 105                 110         
Ile Thr Val Leu Val Pro Pro Arg Asn Leu Met Ile Asp Ile Gln Lys 
        115                 120                 125             
Asp Thr Ala Val Glu Gly Glu Glu Ile Glu Val Asn Cys Thr Ala Met 
    130                 135                 140                 
Ala Ser Lys Pro Ala Thr Thr Ile Arg Trp Phe Lys Gly Asn Thr Glu 
145                 150                 155                 160 
Leu Lys Gly Lys Ser Glu Val Glu Glu Trp Ser Asp Met Tyr Thr Val 
                165                 170                 175     
Thr Ser Gln Leu Met Leu Lys Val His Lys Glu Asp Asp Gly Val Pro 
            180                 185                 190         
Val Ile Cys Gln Val Glu His Pro Ala Val Thr Gly Asn Leu Gln Thr 
        195                 200                 205             
Gln Arg Tyr Leu Glu Val Gln Tyr Lys Pro Gln Val His Ile Gln Met 
    210                 215                 220                 
Thr Tyr Pro Leu Gln Gly Leu Thr Arg Glu Gly Asp Ala Leu Glu Leu 
225                 230                 235                 240 
Thr Cys Glu Ala Ile Gly Lys Pro Gln Pro Val Met Val Thr Trp Val 
                245                 250                 255     
Arg Val Asp Asp Glu Met Pro Gln His Ala Val Leu Ser Gly Pro Asn 
            260                 265                 270         
Leu Phe Ile Asn Asn Leu Asn Lys Thr Asp Asn Gly Thr Tyr Arg Cys 
        275                 280                 285             
Glu Ala Ser Asn Ile Val Gly Lys Ala His Ser Asp Tyr Met Leu Tyr 
    290                 295                 300                 
Val Tyr Asp Pro Pro Thr Thr Ile Pro Pro Pro Thr Thr Thr Thr Thr 
305                 310                 315                 320 
Thr Thr Thr Thr Thr Thr Thr Thr Ile Leu Thr Ile Ile Thr Asp Ser 
                325                 330                 335     
Arg Ala Gly Glu Glu Gly Ser Ile Arg Ala Val Asp His Glu Pro Arg 
            340                 345                 350         
Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
        355                 360                 365             
Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
    370                 375                 380                 
Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp 
385                 390                 395                 400 
Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
                405                 410                 415     
Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
            420                 425                 430         
Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
        435                 440                 445             
Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro 
    450                 455                 460                 
Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
465                 470                 475                 480 
Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
                485                 490                 495     
Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
            500                 505                 510         
Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
        515                 520                 525             
Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
    530                 535                 540                 
Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
545                 550                 555                 560 
Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
                565                 570                 575     
Ser Arg Thr Pro Gly Lys 
            580         

<210>  41
<211>  581
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  human-CADM1-ECD-hFc

<400>  41
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Gln Asn Leu Phe Thr Lys Asp Val Thr Val Ile Glu Gly 
            20                  25                  30          
Glu Val Ala Thr Ile Ser Cys Gln Val Asn Lys Ser Asp Asp Ser Val 
        35                  40                  45              
Ile Gln Leu Leu Asn Pro Asn Arg Gln Thr Ile Tyr Phe Arg Asp Phe 
    50                  55                  60                  
Arg Pro Leu Lys Asp Ser Arg Phe Gln Leu Leu Asn Phe Ser Ser Ser 
65                  70                  75                  80  
Glu Leu Lys Val Ser Leu Thr Asn Val Ser Ile Ser Asp Glu Gly Arg 
                85                  90                  95      
Tyr Phe Cys Gln Leu Tyr Thr Asp Pro Pro Gln Glu Ser Tyr Thr Thr 
            100                 105                 110         
Ile Thr Val Leu Val Pro Pro Arg Asn Leu Met Ile Asp Ile Gln Lys 
        115                 120                 125             
Asp Thr Ala Val Glu Gly Glu Glu Ile Glu Val Asn Cys Thr Ala Met 
    130                 135                 140                 
Ala Ser Lys Pro Ala Thr Thr Ile Arg Trp Phe Lys Gly Asn Thr Glu 
145                 150                 155                 160 
Leu Lys Gly Lys Ser Glu Val Glu Glu Trp Ser Asp Met Tyr Thr Val 
                165                 170                 175     
Thr Ser Gln Leu Met Leu Lys Val His Lys Glu Asp Asp Gly Val Pro 
            180                 185                 190         
Val Ile Cys Gln Val Glu His Pro Ala Val Thr Gly Asn Leu Gln Thr 
        195                 200                 205             
Gln Arg Tyr Leu Glu Val Gln Tyr Lys Pro Gln Val His Ile Gln Met 
    210                 215                 220                 
Thr Tyr Pro Leu Gln Gly Leu Thr Arg Glu Gly Asp Ala Leu Glu Leu 
225                 230                 235                 240 
Thr Cys Glu Ala Ile Gly Lys Pro Gln Pro Val Met Val Thr Trp Val 
                245                 250                 255     
Arg Val Asp Asp Glu Met Pro Gln His Ala Val Leu Ser Gly Pro Asn 
            260                 265                 270         
Leu Phe Ile Asn Asn Leu Asn Lys Thr Asp Asn Gly Thr Tyr Arg Cys 
        275                 280                 285             
Glu Ala Ser Asn Ile Val Gly Lys Ala His Ser Asp Tyr Met Leu Tyr 
    290                 295                 300                 
Val Tyr Asp Pro Pro Thr Thr Ile Pro Pro Pro Thr Thr Thr Thr Thr 
305                 310                 315                 320 
Thr Thr Thr Thr Thr Thr Thr Thr Ile Leu Thr Ile Ile Thr Asp Ser 
                325                 330                 335     
Arg Ala Gly Glu Glu Gly Ser Ile Arg Ala Val Asp His Glu Pro Lys 
            340                 345                 350         
Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        355                 360                 365             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    370                 375                 380                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
385                 390                 395                 400 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                405                 410                 415     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            420                 425                 430         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        435                 440                 445             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    450                 455                 460                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
465                 470                 475                 480 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                485                 490                 495     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            500                 505                 510         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        515                 520                 525             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    530                 535                 540                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
545                 550                 555                 560 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                565                 570                 575     
Leu Ser Pro Gly Lys 
            580     

<210>  42
<211>  394
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  human-CADM1-ECD-Myc-10His

<400>  42
Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      
Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          
Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              
Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  
Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  
Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      
Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         
Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             
Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 
Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 
Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     
Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         
Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             
Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 
Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 
Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     
Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         
Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             
Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 
Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 
Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Pro Pro Thr Thr 
                325                 330                 335     
Ile Pro Pro Pro Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr 
            340                 345                 350         
Thr Ile Leu Thr Ile Ile Thr Asp Ser Arg Ala Gly Glu Glu Gly Ser 
        355                 360                 365             
Ile Arg Ala Val Asp His Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
    370                 375                 380                 
His His His His His His His His His His 
385                 390                 

<210>  43
<211>  449
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  5A11抗体的重链

<400>  43
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          
Ala Met Tyr Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Thr Lys Thr Asn Asn Tyr Ala Ala His Tyr Val Glu 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      
Tyr Cys Thr Ser Val Pro Gln Gly Thr Gln Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Glu His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys 
    

<210>  44
<211>  214
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  5A11抗体的轻链

<400>  44
Ser Tyr Glu Leu Thr Gln Pro Ser Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      
Thr Ala Arg Ile Thr Cys Ser Gly Asp Val Leu Ser Lys Arg Tyr Ala 
            20                  25                  30          
Gln Trp Ser Gln Gln Lys Pro Gly Gln Ala Ile Val Ser Val Ile Tyr 
        35                  40                  45              
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  
Ser Ser Gly Thr Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Leu Ser Thr Tyr Ala Asp Asp Asn Leu 
                85                  90                  95      
Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 
Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 
Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     
Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         
Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             
Ala Pro Thr Glu Cys Ser 
    210                 

<210>  45
<211>  114
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  45
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Arg Leu Glu Trp 
        35                  40                  45              
Met Gly Tyr Ile Asn Tyr Ser Gly Thr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Gly Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  
Leu His Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Phe Tyr Cys 
                85                  90                  95      
Ser Arg Arg Phe Leu Asp Tyr Trp Gly Arg Gly Thr Ser Leu Thr Val 
            100                 105                 110         
Ser Ser 
        

<210>  46
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  46
Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Gly His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Phe Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Ile Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  47
<211>  444
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链

<400>  47
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Arg Leu Glu Trp 
        35                  40                  45              
Met Gly Tyr Ile Asn Tyr Ser Gly Thr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Gly Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  
Leu His Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Phe Tyr Cys 
                85                  90                  95      
Ser Arg Arg Phe Leu Asp Tyr Trp Gly Arg Gly Thr Ser Leu Thr Val 
            100                 105                 110         
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             
Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         
Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             
Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     
Thr Cys Val Val Val Asp Val Glu His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 
Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 

<210>  48
<211>  218
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链

<400>  48
Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Gly His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Phe Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Ile Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 
Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         
Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215             

<210>  49
<211>  444
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链

<400>  49
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Arg Leu Glu Trp 
        35                  40                  45              
Met Gly Tyr Ile Ser Tyr Ser Gly Thr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Gly Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  
Leu His Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Phe Tyr Cys 
                85                  90                  95      
Ser Arg Arg Phe Leu Asp Tyr Trp Gly Arg Gly Thr Ser Leu Thr Val 
            100                 105                 110         
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             
Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         
Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             
Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     
Thr Cys Val Val Val Asp Val Glu His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 
Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 

<210>  50
<211>  114
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  50
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Tyr Ile Ser Tyr Ser Gly Thr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg Phe Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210>  51
<211>  114
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  51
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Tyr Ile Ser Tyr Ser Gly Thr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg Phe Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210>  52
<211>  114
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  52
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Tyr Ile Ser Tyr Ser Gly Thr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Phe Tyr Cys 
                85                  90                  95      
Ser Arg Arg Phe Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210>  53
<211>  114
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  53
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Met Gly Tyr Ile Ser Tyr Ser Gly Thr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Gly Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Phe Tyr Cys 
                85                  90                  95      
Ser Arg Arg Phe Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210>  54
<211>  114
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  54
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Met Gly Tyr Ile Ser Tyr Ser Gly Thr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Gly Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Phe Tyr Cys 
                85                  90                  95      
Ser Arg Arg Phe Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210>  55
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  55
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Gly His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Arg Arg Leu Ile Tyr Lys Val Phe Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         

<210>  56
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  56
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Gly His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Arg Arg Leu Ile Tyr Lys Val Phe Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         

<210>  57
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  57
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Gly His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Arg Arg Leu Ile Tyr Lys Val Phe Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         

<210>  58
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  58
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Gly His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Phe Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         

<210>  59
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  59
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Gly His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Phe Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         

<210>  60
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  60
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Ser Leu Gly His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Phe Asn Arg Phe Ser Gly Ile Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         

<210>  61
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  61
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Ser Leu Gly His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ala 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Phe Asn Arg Phe Ser Gly Ile Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         

<210>  62
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  62
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Ser Leu Gly His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ala 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Phe Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         

<210>  63
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  63
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Ser Leu Gly His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ala 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Phe Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Arg Leu Glu Pro Glu Asp Phe Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         

<210>  64
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  64
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Ser Leu Gly His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ala 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Phe Asn Arg Phe Ser Gly Ile Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Arg Leu Glu Pro Glu Asp Phe Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         

<210>  65
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  65
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Ser Leu Gly His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ala 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Phe Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Arg Leu Glu Pro Glu Asp Phe Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         

<210>  66
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  66
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Ser Leu Gly His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ala 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Phe Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Arg Val Glu Pro Glu Asp Phe Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         

<210>  67
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  67
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Ser Leu Gly His Ser 
            20                  25                  30          
Asn Lys Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ala 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Phe Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Arg Val Glu Pro Glu Asp Phe Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         

<210>  68
<211>  116
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  68
Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Ser 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Ser Ser Gly Gly Asp Tyr Thr Tyr Tyr Ser Asp Asn Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Thr Leu Gly Tyr Asp Glu Ala Asp Tyr Trp Gly Gln Gly Ser Thr Leu 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210>  69
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  69
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Glu 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp Thr Phe Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  70
<211>  446
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链

<400>  70
Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Ser 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Ser Ser Gly Gly Asp Tyr Thr Tyr Tyr Ser Asp Asn Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Thr Leu Gly Tyr Asp Glu Ala Asp Tyr Trp Gly Gln Gly Ser Thr Leu 
            100                 105                 110         
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             
Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 
Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     
Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         
Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             
Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Glu His Glu Asp Pro Glu Val 
            260                 265                 270         
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 
Lys Val Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     

<210>  71
<211>  213
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链

<400>  71
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Glu 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp Thr Phe Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gln Pro Lys Ala 
            100                 105                 110         
Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             
Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 
Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 
Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     
Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         
Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             
Pro Thr Glu Cys Ser 
    210             

<210>  72
<211>  116
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  72
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Ser 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Ser Ser Gly Gly Asp Tyr Thr Tyr Tyr Ser Asp Asn Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Gly Tyr Asp Glu Ala Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210>  73
<211>  116
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  73
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Ser 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Ser Ser Gly Gly Asp Tyr Thr Tyr Tyr Ser Asp Asn Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Gly Tyr Asp Glu Ala Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210>  74
<211>  116
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  74
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Ser 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Ser Ser Gly Gly Asp Tyr Thr Tyr Tyr Ser Asp Asn Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Leu Gly Tyr Asp Glu Ala Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210>  75
<211>  116
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  75
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Ser 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Ser Ser Gly Gly Asp Tyr Thr Tyr Tyr Ser Asp Asn Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Leu Gly Tyr Asp Glu Ala Asp Tyr Trp Gly Gln Gly Ser Leu Leu 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210>  76
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  76
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Thr Phe Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  77
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  77
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Thr Phe Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  78
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  78
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Thr Phe Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  79
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  79
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Thr Phe Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  80
<211>  114
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  80
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          
Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Tyr Pro Arg Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Arg Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Val His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Gly Leu Val Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         
Ser Ser 
        

<210>  81
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  81
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp His Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  82
<211>  444
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链

<400>  82
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          
Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Tyr Pro Arg Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Arg Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Val His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Gly Leu Val Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             
Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         
Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             
Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     
Thr Cys Val Val Val Asp Val Glu His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 
Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 

<210>  83
<211>  218
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链

<400>  83
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp His Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 
Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         
Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215             

<210>  84
<211>  114
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  84
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          
Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Arg Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Arg Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Leu Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210>  85
<211>  114
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  85
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          
Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Arg Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Arg Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Gly Leu Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210>  86
<211>  114
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  86
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          
Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Tyr Pro Arg Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Arg Gly Arg Val Thr Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Gly Leu Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210>  87
<211>  114
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  87
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          
Asp Ile Asn Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Tyr Pro Arg Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Arg Gly Arg Ala Thr Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Gly Leu Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210>  88
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  88
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  89
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  89
Asp Val Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  90
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  90
Asp Val Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  91
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  91
Asp Val Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Ser Leu Gln Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  92
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  92
Asp Val Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asn Lys Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  93
<211>  115
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  93
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Ser Phe Ser Asn Tyr 
            20                  25                  30          
Trp Ile Glu Trp Val Arg Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Leu Pro Gly Val Pro Thr Ile Tyr Tyr Asn Gly Lys Phe 
    50                  55                  60                  
Lys Asp Lys Ala Thr Phe Thr Ala Asp Ala Ser Ser Asn Thr Ala His 
65                  70                  75                  80  
Met Arg Leu Thr Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Arg Asp Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ala 
        115 

<210>  94
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区


<400>  94
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          
Leu His Trp Phe Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Leu Pro Ser Arg Phe Gly Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Val Glu Ser 
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Asn Trp Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  95
<211>  445
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链

<400>  95
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Ser Phe Ser Asn Tyr 
            20                  25                  30          
Trp Ile Glu Trp Val Arg Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Leu Pro Gly Val Pro Thr Ile Tyr Tyr Asn Gly Lys Phe 
    50                  55                  60                  
Lys Asp Lys Ala Thr Phe Thr Ala Asp Ala Ser Ser Asn Thr Ala His 
65                  70                  75                  80  
Met Arg Leu Thr Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Arg Asp Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Glu His Glu Asp Pro Glu Val Lys 
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 
Val Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 

<210>  96
<211>  213
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链

<400>  96
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          
Leu His Trp Phe Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Leu Pro Ser Arg Phe Gly Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Val Glu Ser 
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Asn Trp Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gln Pro Lys Ala 
            100                 105                 110         
Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             
Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 
Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 
Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     
Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         
Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             
Pro Thr Glu Cys Ser 
    210             

<210>  97
<211>  115
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  97
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Asn Tyr 
            20                  25                  30          
Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Glu Ile Leu Pro Gly Val Pro Thr Ile Tyr Tyr Asn Gly Lys Phe 
    50                  55                  60                  
Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ala 
        115 

<210>  98
<211>  115
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  98
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Asn Tyr 
            20                  25                  30          
Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Leu Pro Gly Val Pro Thr Ile Tyr Tyr Asn Gly Lys Phe 
    50                  55                  60                  
Lys Asp Arg Val Thr Phe Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ala 
        115 

<210>  99
<211>  115
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  99
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Asn Tyr 
            20                  25                  30          
Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Leu Pro Gly Val Pro Thr Ile Tyr Tyr Asn Gly Lys Phe 
    50                  55                  60                  
Lys Asp Arg Val Thr Phe Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Arg Asp Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ala 
        115 

<210>  100
<211>  115
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  100
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Asn Tyr 
            20                  25                  30          
Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Leu Pro Gly Val Pro Thr Ile Tyr Tyr Asn Gly Lys Phe 
    50                  55                  60                  
Lys Asp Lys Ala Thr Phe Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Arg Asp Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ala 
        115 

<210>  101
<211>  115
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  101
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Asn Tyr 
            20                  25                  30          
Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Leu Pro Gly Val Pro Thr Ile Tyr Tyr Asn Ala Lys Phe 
    50                  55                  60                  
Lys Asp Arg Val Thr Phe Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Arg Asp Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ala 
        115 

<210>  102
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  102
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Asn Trp Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  103
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  103
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Asn Trp Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  104
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  104
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          
Leu His Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Asn Trp Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  105
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链可变区

<400>  105
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Val Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          
Leu His Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Leu Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Asn Trp Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  106
<211>  114
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链可变区

<400>  106
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Arg Leu Glu Trp 
        35                  40                  45              
Met Gly Tyr Ile Ser Tyr Ser Gly Thr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Gly Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  
Leu His Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Phe Tyr Cys 
                85                  90                  95      
Ser Arg Arg Phe Leu Asp Tyr Trp Gly Arg Gly Thr Ser Leu Thr Val 
            100                 105                 110         
Ser Ser 
        

<210>  107
<211>  441
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链

<400>  107
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Tyr Ile Ser Tyr Ser Gly Thr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg Phe Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
        115                 120                 125             
Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         
Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             
Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
    210                 215                 220                 
Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            260                 265                 270         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             
Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            340                 345                 350         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 
Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                405                 410                 415     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         
Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440     

<210>  108
<211>  219
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链

<400>  108
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Ser Leu Gly His Ser 
            20                  25                  30          
Asn Lys Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ala 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Phe Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Arg Val Glu Pro Glu Asp Phe Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 

<210>  109
<211>  446
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链

<400>  109
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Ser 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Ser Ser Gly Gly Asp Tyr Thr Tyr Tyr Ser Asp Asn Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Leu Gly Tyr Asp Glu Ala Asp Tyr Trp Gly Gln Gly Ser Leu Leu 
            100                 105                 110         
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             
Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 
Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     
Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         
Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             
Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     

<210>  110
<211>  214
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链

<400>  110
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Thr Phe Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  111
<211>  441
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链

<400>  111
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          
Asp Ile Asn Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Tyr Pro Arg Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Arg Gly Arg Ala Thr Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Gly Leu Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
        115                 120                 125             
Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         
Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             
Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
    210                 215                 220                 
Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            260                 265                 270         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             
Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            340                 345                 350         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 
Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                405                 410                 415     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         
Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440     

<210>  112
<211>  219
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链

<400>  112
Asp Val Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asn Lys Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      
Thr Arg Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 

<210>  113
<211>  445
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  重链

<400>  113
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Asn Tyr 
            20                  25                  30          
Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Leu Pro Gly Val Pro Thr Ile Tyr Tyr Asn Ala Lys Phe 
    50                  55                  60                  
Lys Asp Arg Val Thr Phe Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Arg Asp Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 

<210>  114
<211>  214
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  轻链

<400>  114
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          
Leu His Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Asn Trp Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

