                         б

<110>  ҽƴѧ
 
<120>  ø

<130>  FPCH21160341P

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  390
<212>  PRT
<213>  ˹

<220>
<223>  HyperLigase

<400>  1

Met Thr Trp Ile Lys Asn Pro Glu Pro Trp Met Val Asn Leu Val Ala 
1               5                   10                  15      


Glu Lys Leu Gly Leu Asp Val Glu Arg Val Glu Thr Leu Ala Arg His 
            20                  25                  30          


Gly Thr Ile Arg Phe Arg Gly Tyr Arg Asp Val Val Tyr Ala Leu Leu 
        35                  40                  45              


Arg Arg Glu Ile Ala Gly His Pro Glu Gly Thr Val Val Leu Leu Glu 
    50                  55                  60                  


Arg Asn Gly Ala Arg Leu Val Pro Gly Tyr Pro Pro Ile Gln Arg Met 
65                  70                  75                  80  


Val Leu Pro Thr Ile Ala Leu Pro Arg His Phe Ile Asp Lys Val Val 
                85                  90                  95      


Val Glu Glu Ala Met Asn Gly Tyr Asn Val Arg Leu Val Met Phe His 
            100                 105                 110         


Arg Lys Leu Leu Ala Val Thr Arg Gly Gly Phe Ile Cys Pro Tyr Thr 
        115                 120                 125             


Thr Ala Arg Leu Glu Arg Leu Ile Gly Gly Arg Val Arg Glu Leu Phe 
    130                 135                 140                 


Arg Glu Ile Asp Pro Glu Thr Tyr Thr Ile Ala Gly Glu Val Val Gly 
145                 150                 155                 160 


Leu Glu Asn Pro Tyr Thr Arg Tyr Phe Tyr Pro Glu Ala Pro Arg Phe 
                165                 170                 175     


Asp Tyr Phe Val Phe Asp Leu Phe His Glu Leu Lys Pro Leu Pro Pro 
            180                 185                 190         


Leu Glu Arg Asn Glu Leu Leu Glu Lys Tyr Gly Leu Lys His Val Arg 
        195                 200                 205             


Leu Leu Gly Val Ile Asp Lys Asn Asp Val Glu Met Phe Lys Gln Ile 
    210                 215                 220                 


Val Ala Glu Leu Asp Arg Glu Gly Arg Glu Gly Val Val Ala Lys Asp 
225                 230                 235                 240 


Pro Glu Tyr Arg Val Pro Pro Leu Lys Tyr Thr Thr Ser Ala Val Asn 
                245                 250                 255     


Ile Gly Asp Val Arg Tyr Gly Met Arg Phe Phe Met Glu Glu Gly Arg 
            260                 265                 270         


Ser Phe Leu Phe Ser Arg Leu Leu Arg Glu Leu Phe Arg Ala Tyr Glu 
        275                 280                 285             


Glu Gly Phe Gly Asp Ala Gln Leu Glu Lys Leu Ala Leu Glu Phe Gly 
    290                 295                 300                 


Arg Ala Ala Thr Glu Pro Ala Leu Glu Ser Ile Arg Lys Val Ala Met 
305                 310                 315                 320 


Gly Asp Met Leu Tyr Glu Glu Phe Glu Leu Val Phe Ala Asp Glu Val 
                325                 330                 335     


Glu Leu Glu Glu Phe Thr Ser Tyr Met Ala Glu Leu Gly Val Asp Ile 
            340                 345                 350         


Val Val Val Ser Thr Ser Arg Glu Asp Glu Gly Leu Arg Ala Arg Met 
        355                 360                 365             


Arg Lys Ile Lys Asp Thr Trp Ile Gln Leu Arg Lys Val Leu Asp Thr 
    370                 375                 380                 


Gly Leu Ser Pro Val Asp 
385                 390 


<210>  2
<211>  390
<212>  PRT
<213>  ˹

<220>
<223>  HyperligaseR79ͻ


<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  XaaArg֮κȻ

<400>  2

Met Thr Trp Ile Lys Asn Pro Glu Pro Trp Met Val Asn Leu Val Ala 
1               5                   10                  15      


Glu Lys Leu Gly Leu Asp Val Glu Arg Val Glu Thr Leu Ala Arg His 
            20                  25                  30          


Gly Thr Ile Arg Phe Arg Gly Tyr Arg Asp Val Val Tyr Ala Leu Leu 
        35                  40                  45              


Arg Arg Glu Ile Ala Gly His Pro Glu Gly Thr Val Val Leu Leu Glu 
    50                  55                  60                  


Arg Asn Gly Ala Arg Leu Val Pro Gly Tyr Pro Pro Ile Gln Xaa Met 
65                  70                  75                  80  


Val Leu Pro Thr Ile Ala Leu Pro Arg His Phe Ile Asp Lys Val Val 
                85                  90                  95      


Val Glu Glu Ala Met Asn Gly Tyr Asn Val Arg Leu Val Met Phe His 
            100                 105                 110         


Arg Lys Leu Leu Ala Val Thr Arg Gly Gly Phe Ile Cys Pro Tyr Thr 
        115                 120                 125             


Thr Ala Arg Leu Glu Arg Leu Ile Gly Gly Arg Val Arg Glu Leu Phe 
    130                 135                 140                 


Arg Glu Ile Asp Pro Glu Thr Tyr Thr Ile Ala Gly Glu Val Val Gly 
145                 150                 155                 160 


Leu Glu Asn Pro Tyr Thr Arg Tyr Phe Tyr Pro Glu Ala Pro Arg Phe 
                165                 170                 175     


Asp Tyr Phe Val Phe Asp Leu Phe His Glu Leu Lys Pro Leu Pro Pro 
            180                 185                 190         


Leu Glu Arg Asn Glu Leu Leu Glu Lys Tyr Gly Leu Lys His Val Arg 
        195                 200                 205             


Leu Leu Gly Val Ile Asp Lys Asn Asp Val Glu Met Phe Lys Gln Ile 
    210                 215                 220                 


Val Ala Glu Leu Asp Arg Glu Gly Arg Glu Gly Val Val Ala Lys Asp 
225                 230                 235                 240 


Pro Glu Tyr Arg Val Pro Pro Leu Lys Tyr Thr Thr Ser Ala Val Asn 
                245                 250                 255     


Ile Gly Asp Val Arg Tyr Gly Met Arg Phe Phe Met Glu Glu Gly Arg 
            260                 265                 270         


Ser Phe Leu Phe Ser Arg Leu Leu Arg Glu Leu Phe Arg Ala Tyr Glu 
        275                 280                 285             


Glu Gly Phe Gly Asp Ala Gln Leu Glu Lys Leu Ala Leu Glu Phe Gly 
    290                 295                 300                 


Arg Ala Ala Thr Glu Pro Ala Leu Glu Ser Ile Arg Lys Val Ala Met 
305                 310                 315                 320 


Gly Asp Met Leu Tyr Glu Glu Phe Glu Leu Val Phe Ala Asp Glu Val 
                325                 330                 335     


Glu Leu Glu Glu Phe Thr Ser Tyr Met Ala Glu Leu Gly Val Asp Ile 
            340                 345                 350         


Val Val Val Ser Thr Ser Arg Glu Asp Glu Gly Leu Arg Ala Arg Met 
        355                 360                 365             


Arg Lys Ile Lys Asp Thr Trp Ile Gln Leu Arg Lys Val Leu Asp Thr 
    370                 375                 380                 


Gly Leu Ser Pro Val Asp 
385                 390 


<210>  3
<211>  390
<212>  PRT
<213>  ˹

<220>
<223>  HyperLigaseR281ͻ


<220>
<221>  misc_feature
<222>  (281)..(281)
<223>  XaaArg֮κȻ

<400>  3

Met Thr Trp Ile Lys Asn Pro Glu Pro Trp Met Val Asn Leu Val Ala 
1               5                   10                  15      


Glu Lys Leu Gly Leu Asp Val Glu Arg Val Glu Thr Leu Ala Arg His 
            20                  25                  30          


Gly Thr Ile Arg Phe Arg Gly Tyr Arg Asp Val Val Tyr Ala Leu Leu 
        35                  40                  45              


Arg Arg Glu Ile Ala Gly His Pro Glu Gly Thr Val Val Leu Leu Glu 
    50                  55                  60                  


Arg Asn Gly Ala Arg Leu Val Pro Gly Tyr Pro Pro Ile Gln Arg Met 
65                  70                  75                  80  


Val Leu Pro Thr Ile Ala Leu Pro Arg His Phe Ile Asp Lys Val Val 
                85                  90                  95      


Val Glu Glu Ala Met Asn Gly Tyr Asn Val Arg Leu Val Met Phe His 
            100                 105                 110         


Arg Lys Leu Leu Ala Val Thr Lys Gly Gly Phe Ile Cys Pro Tyr Thr 
        115                 120                 125             


Thr Ala Arg Leu Glu Arg Leu Ile Gly Gly Arg Val Arg Glu Leu Phe 
    130                 135                 140                 


Arg Glu Ile Asp Pro Glu Thr Tyr Thr Ile Ala Gly Glu Val Val Gly 
145                 150                 155                 160 


Leu Glu Asn Pro Tyr Thr Arg Tyr Phe Tyr Pro Glu Ala Pro Arg Phe 
                165                 170                 175     


Asp Tyr Phe Val Phe Asp Leu Phe His Glu Leu Lys Pro Leu Pro Pro 
            180                 185                 190         


Leu Glu Arg Asn Glu Leu Leu Glu Lys Tyr Gly Leu Lys His Val Arg 
        195                 200                 205             


Leu Leu Gly Val Ile Asp Lys Asn Asp Val Glu Met Phe Lys Gln Ile 
    210                 215                 220                 


Val Ala Glu Leu Asp Arg Glu Gly Arg Glu Gly Val Val Ala Lys Asp 
225                 230                 235                 240 


Pro Glu Tyr Arg Val Pro Pro Leu Lys Tyr Thr Thr Ser Ala Val Asn 
                245                 250                 255     


Ile Gly Asp Val Arg Tyr Gly Met Arg Phe Phe Met Glu Glu Gly Arg 
            260                 265                 270         


Ser Phe Leu Phe Ser Arg Leu Leu Xaa Glu Leu Phe Arg Ala Tyr Glu 
        275                 280                 285             


Glu Gly Phe Gly Asp Ala Gln Leu Glu Lys Leu Ala Leu Glu Phe Gly 
    290                 295                 300                 


Arg Ala Ala Thr Glu Pro Ala Leu Glu Ser Ile Arg Lys Val Ala Met 
305                 310                 315                 320 


Gly Asp Met Leu Tyr Glu Glu Phe Glu Leu Val Phe Ala Asp Glu Val 
                325                 330                 335     


Glu Leu Glu Glu Phe Thr Ser Tyr Met Ala Glu Leu Gly Val Asp Ile 
            340                 345                 350         


Val Val Val Ser Thr Ser Arg Glu Asp Glu Gly Leu Arg Ala Arg Met 
        355                 360                 365             


Arg Lys Ile Lys Asp Thr Trp Ile Gln Leu Arg Lys Val Leu Asp Thr 
    370                 375                 380                 


Gly Leu Ser Pro Val Asp 
385                 390 


<210>  4
<211>  390
<212>  PRT
<213>  ˹

<220>
<223>  HyperligaseK370ͻ


<220>
<221>  misc_feature
<222>  (370)..(370)
<223>  XaaLys֮κȻ

<400>  4

Met Thr Trp Ile Lys Asn Pro Glu Pro Trp Met Val Asn Leu Val Ala 
1               5                   10                  15      


Glu Lys Leu Gly Leu Asp Val Glu Arg Val Glu Thr Leu Ala Arg His 
            20                  25                  30          


Gly Thr Ile Arg Phe Arg Gly Tyr Arg Asp Val Val Tyr Ala Leu Leu 
        35                  40                  45              


Arg Arg Glu Ile Ala Gly His Pro Glu Gly Thr Val Val Leu Leu Glu 
    50                  55                  60                  


Arg Asn Gly Ala Arg Leu Val Pro Gly Tyr Pro Pro Ile Gln Arg Met 
65                  70                  75                  80  


Val Leu Pro Thr Ile Ala Leu Pro Arg His Phe Ile Asp Lys Val Val 
                85                  90                  95      


Val Glu Glu Ala Met Asn Gly Tyr Asn Val Arg Leu Val Met Phe His 
            100                 105                 110         


Arg Lys Leu Leu Ala Val Thr Lys Gly Gly Phe Ile Cys Pro Tyr Thr 
        115                 120                 125             


Thr Ala Arg Leu Glu Arg Leu Ile Gly Gly Arg Val Arg Glu Leu Phe 
    130                 135                 140                 


Arg Glu Ile Asp Pro Glu Thr Tyr Thr Ile Ala Gly Glu Val Val Gly 
145                 150                 155                 160 


Leu Glu Asn Pro Tyr Thr Arg Tyr Phe Tyr Pro Glu Ala Pro Arg Phe 
                165                 170                 175     


Asp Tyr Phe Val Phe Asp Leu Phe His Glu Leu Lys Pro Leu Pro Pro 
            180                 185                 190         


Leu Glu Arg Asn Glu Leu Leu Glu Lys Tyr Gly Leu Lys His Val Arg 
        195                 200                 205             


Leu Leu Gly Val Ile Asp Lys Asn Asp Val Glu Met Phe Lys Gln Ile 
    210                 215                 220                 


Val Ala Glu Leu Asp Arg Glu Gly Arg Glu Gly Val Val Ala Lys Asp 
225                 230                 235                 240 


Pro Glu Tyr Arg Val Pro Pro Leu Lys Tyr Thr Thr Ser Ala Val Asn 
                245                 250                 255     


Ile Gly Asp Val Arg Tyr Gly Met Arg Phe Phe Met Glu Glu Gly Arg 
            260                 265                 270         


Ser Phe Leu Phe Ser Arg Leu Leu Arg Glu Leu Phe Arg Ala Tyr Glu 
        275                 280                 285             


Glu Gly Phe Gly Asp Ala Gln Leu Glu Lys Leu Ala Leu Glu Phe Gly 
    290                 295                 300                 


Arg Ala Ala Thr Glu Pro Ala Leu Glu Ser Ile Arg Lys Val Ala Met 
305                 310                 315                 320 


Gly Asp Met Leu Tyr Glu Glu Phe Glu Leu Val Phe Ala Asp Glu Val 
                325                 330                 335     


Glu Leu Glu Glu Phe Thr Ser Tyr Met Ala Glu Leu Gly Val Asp Ile 
            340                 345                 350         


Val Val Val Ser Thr Ser Arg Glu Asp Glu Gly Leu Arg Ala Arg Met 
        355                 360                 365             


Arg Xaa Ile Lys Asp Thr Trp Ile Gln Leu Arg Lys Val Leu Asp Thr 
    370                 375                 380                 


Gly Leu Ser Pro Val Asp 
385                 390 


<210>  5
<211>  390
<212>  PRT
<213>  ˹

<220>
<223>  HyperLigaseK372ͻ

<220>
<221>  misc_feature
<222>  (372)..(372)
<223>  XaaLys֮κȻ

<400>  5

Met Thr Trp Ile Lys Asn Pro Glu Pro Trp Met Val Asn Leu Val Ala 
1               5                   10                  15      


Glu Lys Leu Gly Leu Asp Val Glu Arg Val Glu Thr Leu Ala Arg His 
            20                  25                  30          


Gly Thr Ile Arg Phe Arg Gly Tyr Arg Asp Val Val Tyr Ala Leu Leu 
        35                  40                  45              


Arg Arg Glu Ile Ala Gly His Pro Glu Gly Thr Val Val Leu Leu Glu 
    50                  55                  60                  


Arg Asn Gly Ala Arg Leu Val Pro Gly Tyr Pro Pro Ile Gln Arg Met 
65                  70                  75                  80  


Val Leu Pro Thr Ile Ala Leu Pro Arg His Phe Ile Asp Lys Val Val 
                85                  90                  95      


Val Glu Glu Ala Met Asn Gly Tyr Asn Val Arg Leu Val Met Phe His 
            100                 105                 110         


Arg Lys Leu Leu Ala Val Thr Lys Gly Gly Phe Ile Cys Pro Tyr Thr 
        115                 120                 125             


Thr Ala Arg Leu Glu Arg Leu Ile Gly Gly Arg Val Arg Glu Leu Phe 
    130                 135                 140                 


Arg Glu Ile Asp Pro Glu Thr Tyr Thr Ile Ala Gly Glu Val Val Gly 
145                 150                 155                 160 


Leu Glu Asn Pro Tyr Thr Arg Tyr Phe Tyr Pro Glu Ala Pro Arg Phe 
                165                 170                 175     


Asp Tyr Phe Val Phe Asp Leu Phe His Glu Leu Lys Pro Leu Pro Pro 
            180                 185                 190         


Leu Glu Arg Asn Glu Leu Leu Glu Lys Tyr Gly Leu Lys His Val Arg 
        195                 200                 205             


Leu Leu Gly Val Ile Asp Lys Asn Asp Val Glu Met Phe Lys Gln Ile 
    210                 215                 220                 


Val Ala Glu Leu Asp Arg Glu Gly Arg Glu Gly Val Val Ala Lys Asp 
225                 230                 235                 240 


Pro Glu Tyr Arg Val Pro Pro Leu Lys Tyr Thr Thr Ser Ala Val Asn 
                245                 250                 255     


Ile Gly Asp Val Arg Tyr Gly Met Arg Phe Phe Met Glu Glu Gly Arg 
            260                 265                 270         


Ser Phe Leu Phe Ser Arg Leu Leu Arg Glu Leu Phe Arg Ala Tyr Glu 
        275                 280                 285             


Glu Gly Phe Gly Asp Ala Gln Leu Glu Lys Leu Ala Leu Glu Phe Gly 
    290                 295                 300                 


Arg Ala Ala Thr Glu Pro Ala Leu Glu Ser Ile Arg Lys Val Ala Met 
305                 310                 315                 320 


Gly Asp Met Leu Tyr Glu Glu Phe Glu Leu Val Phe Ala Asp Glu Val 
                325                 330                 335     


Glu Leu Glu Glu Phe Thr Ser Tyr Met Ala Glu Leu Gly Val Asp Ile 
            340                 345                 350         


Val Val Val Ser Thr Ser Arg Glu Asp Glu Gly Leu Arg Ala Arg Met 
        355                 360                 365             


Arg Lys Ile Xaa Asp Thr Trp Ile Gln Leu Arg Lys Val Leu Asp Thr 
    370                 375                 380                 


Gly Leu Ser Pro Val Asp 
385                 390 


<210>  6
<211>  390
<212>  PRT
<213>  ˹

<220>
<223>  HyperLigaseK370K372ͻ

<220>
<221>  misc_feature
<222>  (370)..(370)
<223>  XaaLys֮κȻ

<220>
<221>  misc_feature
<222>  (372)..(372)
<223>  XaaLys֮κȻ

<400>  6

Met Thr Trp Ile Lys Asn Pro Glu Pro Trp Met Val Asn Leu Val Ala 
1               5                   10                  15      


Glu Lys Leu Gly Leu Asp Val Glu Arg Val Glu Thr Leu Ala Arg His 
            20                  25                  30          


Gly Thr Ile Arg Phe Arg Gly Tyr Arg Asp Val Val Tyr Ala Leu Leu 
        35                  40                  45              


Arg Arg Glu Ile Ala Gly His Pro Glu Gly Thr Val Val Leu Leu Glu 
    50                  55                  60                  


Arg Asn Gly Ala Arg Leu Val Pro Gly Tyr Pro Pro Ile Gln Arg Met 
65                  70                  75                  80  


Val Leu Pro Thr Ile Ala Leu Pro Arg His Phe Ile Asp Lys Val Val 
                85                  90                  95      


Val Glu Glu Ala Met Asn Gly Tyr Asn Val Arg Leu Val Met Phe His 
            100                 105                 110         


Arg Lys Leu Leu Ala Val Thr Arg Gly Gly Phe Ile Cys Pro Tyr Thr 
        115                 120                 125             


Thr Ala Arg Leu Glu Arg Leu Ile Gly Gly Arg Val Arg Glu Leu Phe 
    130                 135                 140                 


Arg Glu Ile Asp Pro Glu Thr Tyr Thr Ile Ala Gly Glu Val Val Gly 
145                 150                 155                 160 


Leu Glu Asn Pro Tyr Thr Arg Tyr Phe Tyr Pro Glu Ala Pro Arg Phe 
                165                 170                 175     


Asp Tyr Phe Val Phe Asp Leu Phe His Glu Leu Lys Pro Leu Pro Pro 
            180                 185                 190         


Leu Glu Arg Asn Glu Leu Leu Glu Lys Tyr Gly Leu Lys His Val Arg 
        195                 200                 205             


Leu Leu Gly Val Ile Asp Lys Asn Asp Val Glu Met Phe Lys Gln Ile 
    210                 215                 220                 


Val Ala Glu Leu Asp Arg Glu Gly Arg Glu Gly Val Val Ala Lys Asp 
225                 230                 235                 240 


Pro Glu Tyr Arg Val Pro Pro Leu Lys Tyr Thr Thr Ser Ala Val Asn 
                245                 250                 255     


Ile Gly Asp Val Arg Tyr Gly Met Arg Phe Phe Met Glu Glu Gly Arg 
            260                 265                 270         


Ser Phe Leu Phe Ser Arg Leu Leu Arg Glu Leu Phe Arg Ala Tyr Glu 
        275                 280                 285             


Glu Gly Phe Gly Asp Ala Gln Leu Glu Lys Leu Ala Leu Glu Phe Gly 
    290                 295                 300                 


Arg Ala Ala Thr Glu Pro Ala Leu Glu Ser Ile Arg Lys Val Ala Met 
305                 310                 315                 320 


Gly Asp Met Leu Tyr Glu Glu Phe Glu Leu Val Phe Ala Asp Glu Val 
                325                 330                 335     


Glu Leu Glu Glu Phe Thr Ser Tyr Met Ala Glu Leu Gly Val Asp Ile 
            340                 345                 350         


Val Val Val Ser Thr Ser Arg Glu Asp Glu Gly Leu Arg Ala Arg Met 
        355                 360                 365             


Arg Xaa Ile Xaa Asp Thr Trp Ile Gln Leu Arg Lys Val Leu Asp Thr 
    370                 375                 380                 


Gly Leu Ser Pro Val Asp 
385                 390 


<210>  7
<211>  390
<212>  PRT
<213>  ˹

<220>
<223>  Hyperligaseλͻ


<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  XaaArg֮κȻ

<220>
<221>  misc_feature
<222>  (281)..(281)
<223>  XaaArg֮κȻ

<220>
<221>  misc_feature
<222>  (370)..(370)
<223>  XaaLys֮κȻ

<220>
<221>  misc_feature
<222>  (372)..(372)
<223>  XaaLys֮κȻ

<400>  7

Met Thr Trp Ile Lys Asn Pro Glu Pro Trp Met Val Asn Leu Val Ala 
1               5                   10                  15      


Glu Lys Leu Gly Leu Asp Val Glu Arg Val Glu Thr Leu Ala Arg His 
            20                  25                  30          


Gly Thr Ile Arg Phe Arg Gly Tyr Arg Asp Val Val Tyr Ala Leu Leu 
        35                  40                  45              


Arg Arg Glu Ile Ala Gly His Pro Glu Gly Thr Val Val Leu Leu Glu 
    50                  55                  60                  


Arg Asn Gly Ala Arg Leu Val Pro Gly Tyr Pro Pro Ile Gln Xaa Met 
65                  70                  75                  80  


Val Leu Pro Thr Ile Ala Leu Pro Arg His Phe Ile Asp Lys Val Val 
                85                  90                  95      


Val Glu Glu Ala Met Asn Gly Tyr Asn Val Arg Leu Val Met Phe His 
            100                 105                 110         


Arg Lys Leu Leu Ala Val Thr Arg Gly Gly Phe Ile Cys Pro Tyr Thr 
        115                 120                 125             


Thr Ala Arg Leu Glu Arg Leu Ile Gly Gly Arg Val Arg Glu Leu Phe 
    130                 135                 140                 


Arg Glu Ile Asp Pro Glu Thr Tyr Thr Ile Ala Gly Glu Val Val Gly 
145                 150                 155                 160 


Leu Glu Asn Pro Tyr Thr Arg Tyr Phe Tyr Pro Glu Ala Pro Arg Phe 
                165                 170                 175     


Asp Tyr Phe Val Phe Asp Leu Phe His Glu Leu Lys Pro Leu Pro Pro 
            180                 185                 190         


Leu Glu Arg Asn Glu Leu Leu Glu Lys Tyr Gly Leu Lys His Val Arg 
        195                 200                 205             


Leu Leu Gly Val Ile Asp Lys Asn Asp Val Glu Met Phe Lys Gln Ile 
    210                 215                 220                 


Val Ala Glu Leu Asp Arg Glu Gly Arg Glu Gly Val Val Ala Lys Asp 
225                 230                 235                 240 


Pro Glu Tyr Arg Val Pro Pro Leu Lys Tyr Thr Thr Ser Ala Val Asn 
                245                 250                 255     


Ile Gly Asp Val Arg Tyr Gly Met Arg Phe Phe Met Glu Glu Gly Arg 
            260                 265                 270         


Ser Phe Leu Phe Ser Arg Leu Leu Xaa Glu Leu Phe Arg Ala Tyr Glu 
        275                 280                 285             


Glu Gly Phe Gly Asp Ala Gln Leu Glu Lys Leu Ala Leu Glu Phe Gly 
    290                 295                 300                 


Arg Ala Ala Thr Glu Pro Ala Leu Glu Ser Ile Arg Lys Val Ala Met 
305                 310                 315                 320 


Gly Asp Met Leu Tyr Glu Glu Phe Glu Leu Val Phe Ala Asp Glu Val 
                325                 330                 335     


Glu Leu Glu Glu Phe Thr Ser Tyr Met Ala Glu Leu Gly Val Asp Ile 
            340                 345                 350         


Val Val Val Ser Thr Ser Arg Glu Asp Glu Gly Leu Arg Ala Arg Met 
        355                 360                 365             


Arg Xaa Ile Xaa Asp Thr Trp Ile Gln Leu Arg Lys Val Leu Asp Thr 
    370                 375                 380                 


Gly Leu Ser Pro Val Asp 
385                 390 






