﻿                         序列表

<110>  徐州医科大学

<120>  新型全人源抗人B7H3抗体和嵌合抗原受体及其用途

<150>  202110736498.8
<151>  2021-06-30

<150>  202110768579.6
<151>  2021-07-07

<150>  202110784331.9
<151>  2021-07-12

<150>  202110783589.7
<151>  2021-07-12

<150>  202110736533.6
<151>  2021-06-30

<150>  202110739700.2
<151>  2021-06-30

<150>  202110768592.1
<151>  2021-07-07

<150>  202110768590.2
<151>  2021-07-07

<150>  202110739303.5
<151>  2021-06-30

<150>  202110739305.4
<151>  2021-06-30

<150>  202110739693.6
<151>  2021-06-30

<160>  68

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  1
Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               

<210>  2
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  2
Gly Phe Gly Phe Ser Gly Tyr Ala 
1               5               

<210>  3
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               

<210>  4
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  4
Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               

<210>  5
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Ala Arg Gly Val Gly Arg Gly Phe Asp Tyr 
1               5                   10  

<210>  6
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Ala Lys Ala Leu Gly Ala Pro Val Tyr 
1               5                   

<210>  7
<211>  117
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  7
Glu Val Gln Leu Phe Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Val Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  8
<211>  115
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  8
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Gly Phe Ser Gly Tyr Ala 
            20                  25                  30          
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        35                  40                  45              
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Lys Ala Leu Gly Ala Pro Val Tyr Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210>  9
<211>  351
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  9
gaggtgcagc tgttccagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc        60
tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct       120
ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac       180
gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat       240
ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc caggggtgtt       300
ggccggggct ttgactactg gggccagggg accacggtca ccgtctcctc a                351

<210>  10
<211>  345
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  10
gtgcagctgg tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc        60
tgtgcagcct ctggattcgg ttttagtggc tatgccatga gctgggtccg ccaggctcca       120
gggaaggggc tggagtgggt ctcagctatc agtggtagtg gtggtagcac atactacgca       180
gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg       240
caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa agctctggga       300
gcaccagtct actggggcca gggaacaatg gtcaccgtct cctca                       345

<210>  11
<211>  6
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  11
Gln Ser Ile Ser Ile Tyr 
1               5       

<210>  12
<211>  6
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  12
Gln Ser Ile Ser Ser Tyr 
1               5       

<210>  13
<211>  3
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  13
Ala Ala Ser 
1           

<210>  14
<211>  3
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  14
Ala Ala Ser 
1           

<210>  15
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  15
Gln Gln Thr Tyr Ser Thr Pro Pro Trp Thr 
1               5                   10  

<210>  16
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  16
Gln Gln Ser Tyr Ser Thr Pro Pro Trp Thr 
1               5                   10  

<210>  17
<211>  108
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  17
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ile Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Arg Gln Gln Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Thr Tyr Ser Thr Pro Pro 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105             

<210>  18
<211>  108
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  18
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105             

<210>  19
<211>  324
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  19
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc        60
atcacttgcc gggcaagtca gagcattagc atctatttaa attggtatcg gcagcaacca       120
gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca       180
aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct       240
gaagattttg caacttactt ctgtcaacag acttacagta cccctccgtg gacgttcggc       300
caagggacca aagtggatat caaa                                              324

<210>  20
<211>  324
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  20
gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc        60
atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca       120
gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca       180
aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct       240
gaagattttg caacttacta ctgtcaacag agttacagta cccctccgtg gacgttcggc       300
caagggacca aagtggatat caaa                                              324

<210>  21
<211>  15
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  21
Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

<210>  22
<211>  15
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  22
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

<210>  23
<211>  45
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  23
agtggcggtg gctctggcgg tggtgggtcg ggtggcggcg gatca                        45

<210>  24
<211>  45
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  24
ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatca                        45

<210>  25
<211>  240
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  25
Glu Val Gln Leu Phe Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Val Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         
Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
    130                 135                 140                 
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
145                 150                 155                 160 
Ile Ser Ile Tyr Leu Asn Trp Tyr Arg Gln Gln Pro Gly Lys Ala Pro 
                165                 170                 175     
Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
            180                 185                 190         
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Thr Tyr 
    210                 215                 220                 
Ser Thr Pro Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
225                 230                 235                 240 

<210>  26
<211>  238
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  26
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Gly Phe Ser Gly Tyr Ala 
            20                  25                  30          
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        35                  40                  45              
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Lys Ala Leu Gly Ala Pro Val Tyr Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
    130                 135                 140                 
Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
145                 150                 155                 160 
Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
                165                 170                 175     
Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
            180                 185                 190         
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
        195                 200                 205             
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
    210                 215                 220                 
Pro Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
225                 230                 235             

<210>  27
<211>  720
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  27
gaggtgcagc tgttccagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc        60
tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct       120
ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac       180
gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat       240
ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc caggggtgtt       300
ggccggggct ttgactactg gggccagggg accacggtca ccgtctcctc aagtggcggt       360
ggctctggcg gtggtgggtc gggtggcggc ggatcagaca tccagttgac ccagtctcca       420
tcctccctgt ctgcatctgt aggagacaga gtcaccatca cttgccgggc aagtcagagc       480
attagcatct atttaaattg gtatcggcag caaccaggga aagcccctaa gctcctgatc       540
tatgctgcat ccagtttgca aagtggggtc ccatcaaggt tcagtggcag tggatctggg       600
acagatttca ctctcaccat cagcagtctg caacctgaag attttgcaac ttacttctgt       660
caacagactt acagtacccc tccgtggacg ttcggccaag ggaccaaagt ggatatcaaa       720

<210>  28
<211>  714
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  28
gtgcagctgg tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc        60
tgtgcagcct ctggattcgg ttttagtggc tatgccatga gctgggtccg ccaggctcca       120
gggaaggggc tggagtgggt ctcagctatc agtggtagtg gtggtagcac atactacgca       180
gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg       240
caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa agctctggga       300
gcaccagtct actggggcca gggaacaatg gtcaccgtct cctcaggtgg cggtggctcg       360
ggcggtggtg ggtcgggtgg cggcggatca gacatcgtga tgacccagtc tccatcctcc       420
ctgtctgcat ctgtaggaga cagagtcacc atcacttgcc gggcaagtca gagcattagc       480
agctatttaa attggtatca gcagaaacca gggaaagccc ctaagctcct gatctatgct       540
gcatccagtt tgcaaagtgg ggtcccatca aggttcagtg gcagtggatc tgggacagat       600
ttcactctca ccatcagcag tctgcaacct gaagattttg caacttacta ctgtcaacag       660
agttacagta cccctccgtg gacgttcggc caagggacca aagtggatat caaa             714

<210>  29
<211>  22
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  29
Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
1               5                   10                  15      
Val Ile Thr Leu Tyr Cys 
            20          

<210>  30
<211>  66
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  30
atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt        60
tactgc                                                                   66

<210>  31
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  31
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         

<210>  32
<211>  336
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  32
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc        60
tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc       120
cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat       180
gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc       240
cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc       300
tacgacgccc ttcacatgca ggccctgccc cctcgc                                 336

<210>  33
<211>  47
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  33
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        35                  40                  45          

<210>  34
<211>  141
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  34
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg        60
tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg       120
gacttcgcct gtgatatcta c                                                 141

<210>  35
<211>  19
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  35
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys 
            

<210>  36
<211>  57
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  36
atggaatttg gcctgagctg gctgtttctg gtggcgattc tgaaaggcgt gcagtgc           57

<210>  37
<211>  41
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  37
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          
Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      

<210>  38
<211>  123
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  38
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc        60
gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc       120
tcc                                                                     123

<210>  39
<211>  48
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  39
Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
1               5                   10                  15      
Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
            20                  25                  30          
Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
        35                  40                  45              

<210>  40
<211>  144
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  40
aggttcagtg tcgtgaagag aggccggaag aagctgctgt acatcttcaa gcagcctttc        60
atgaggcccg tgcagactac ccaggaggaa gatggatgca gctgtagatt ccctgaagag       120
gaggaaggag gctgtgagct gaga                                              144

<210>  41
<211>  21
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  41
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      
Glu Asn Pro Gly Pro 
            20      

<210>  43
<211>  63
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  43
ggatctggag agggcagagg aagtcttcta acatgcggtg acgtggagga gaatcccggc        60
cct                                                                      63

<210>  44
<211>  728
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  44
Met Glu Ala Ala Ala Gly Gly Arg Gly Cys Phe Gln Pro His Pro Gly 
1               5                   10                  15      
Leu Gln Lys Thr Leu Glu Gln Phe His Leu Ser Ser Met Ser Ser Leu 
            20                  25                  30          
Gly Gly Pro Ala Ala Phe Ser Ala Arg Trp Ala Gln Glu Ala Tyr Lys 
        35                  40                  45              
Lys Glu Ser Ala Lys Glu Ala Gly Ala Ala Ala Val Pro Ala Pro Val 
    50                  55                  60                  
Pro Ala Ala Thr Glu Pro Pro Pro Val Leu His Leu Pro Ala Ile Gln 
65                  70                  75                  80  
Pro Pro Pro Pro Val Leu Pro Gly Pro Phe Phe Met Pro Ser Asp Arg 
                85                  90                  95      
Ser Thr Glu Arg Cys Glu Thr Val Leu Glu Gly Glu Thr Ile Ser Cys 
            100                 105                 110         
Phe Val Val Gly Gly Glu Lys Arg Leu Cys Leu Pro Gln Ile Leu Asn 
        115                 120                 125             
Ser Val Leu Arg Asp Phe Ser Leu Gln Gln Ile Asn Ala Val Cys Asp 
    130                 135                 140                 
Glu Leu His Ile Tyr Cys Ser Arg Cys Thr Ala Asp Gln Leu Glu Ile 
145                 150                 155                 160 
Leu Lys Val Met Gly Ile Leu Pro Phe Ser Ala Pro Ser Cys Gly Leu 
                165                 170                 175     
Ile Thr Lys Thr Asp Ala Glu Arg Leu Cys Asn Ala Leu Leu Tyr Gly 
            180                 185                 190         
Gly Ala Tyr Pro Pro Pro Cys Lys Lys Glu Leu Ala Ala Ser Leu Ala 
        195                 200                 205             
Leu Gly Leu Glu Leu Ser Glu Arg Ser Val Arg Val Tyr His Glu Cys 
    210                 215                 220                 
Phe Gly Lys Cys Lys Gly Leu Leu Val Pro Glu Leu Tyr Ser Ser Pro 
225                 230                 235                 240 
Ser Ala Ala Cys Ile Gln Cys Leu Asp Cys Arg Leu Met Tyr Pro Pro 
                245                 250                 255     
His Lys Phe Val Val His Ser His Lys Ala Leu Glu Asn Arg Thr Cys 
            260                 265                 270         
His Trp Gly Phe Asp Ser Ala Asn Trp Arg Ala Tyr Ile Leu Leu Ser 
        275                 280                 285             
Gln Asp Tyr Thr Gly Lys Glu Glu Gln Ala Arg Leu Gly Arg Cys Leu 
    290                 295                 300                 
Asp Asp Val Lys Glu Lys Phe Asp Tyr Gly Asn Lys Tyr Lys Arg Arg 
305                 310                 315                 320 
Val Pro Arg Val Ser Ser Glu Pro Pro Ala Ser Ile Arg Pro Lys Thr 
                325                 330                 335     
Asp Asp Thr Ser Ser Gln Ser Pro Ala Pro Ser Glu Lys Asp Lys Pro 
            340                 345                 350         
Ser Ser Trp Leu Arg Thr Leu Ala Gly Ser Ser Asn Lys Ser Leu Gly 
        355                 360                 365             
Cys Val His Pro Arg Gln Arg Leu Ser Ala Phe Arg Pro Trp Ser Pro 
    370                 375                 380                 
Ala Val Ser Ala Ser Glu Lys Glu Leu Ser Pro His Leu Pro Ala Leu 
385                 390                 395                 400 
Ile Arg Asp Ser Phe Tyr Ser Tyr Lys Ser Phe Glu Thr Ala Val Ala 
                405                 410                 415     
Pro Asn Val Ala Leu Ala Pro Pro Ala Gln Gln Lys Val Val Ser Ser 
            420                 425                 430         
Pro Pro Cys Ala Ala Ala Val Ser Arg Ala Pro Glu Pro Leu Ala Thr 
        435                 440                 445             
Cys Thr Gln Pro Arg Lys Arg Lys Leu Thr Val Asp Thr Pro Gly Ala 
    450                 455                 460                 
Pro Glu Thr Leu Ala Pro Val Ala Ala Pro Glu Glu Asp Lys Asp Ser 
465                 470                 475                 480 
Glu Ala Glu Val Glu Val Glu Ser Arg Glu Glu Phe Thr Ser Ser Leu 
                485                 490                 495     
Ser Ser Leu Ser Ser Pro Ser Phe Thr Ser Ser Ser Ser Ala Lys Asp 
            500                 505                 510         
Leu Gly Ser Pro Gly Ala Arg Ala Leu Pro Ser Ala Val Pro Asp Ala 
        515                 520                 525             
Ala Ala Pro Ala Asp Ala Pro Ser Gly Leu Glu Ala Glu Leu Glu His 
    530                 535                 540                 
Leu Arg Gln Ala Leu Glu Gly Gly Leu Asp Thr Lys Glu Ala Lys Glu 
545                 550                 555                 560 
Lys Phe Leu His Glu Val Val Lys Met Arg Val Lys Gln Glu Glu Lys 
                565                 570                 575     
Leu Ser Ala Ala Leu Gln Ala Lys Arg Ser Leu His Gln Glu Leu Glu 
            580                 585                 590         
Phe Leu Arg Val Ala Lys Lys Glu Lys Leu Arg Glu Ala Thr Glu Ala 
        595                 600                 605             
Lys Arg Asn Leu Arg Lys Glu Ile Glu Arg Leu Arg Ala Glu Asn Glu 
    610                 615                 620                 
Lys Lys Met Lys Glu Ala Asn Glu Ser Arg Leu Arg Leu Lys Arg Glu 
625                 630                 635                 640 
Leu Glu Gln Ala Arg Gln Ala Arg Val Cys Asp Lys Gly Cys Glu Ala 
                645                 650                 655     
Gly Arg Leu Arg Ala Lys Tyr Ser Ala Gln Ile Glu Asp Leu Gln Val 
            660                 665                 670         
Lys Leu Gln His Ala Glu Ala Asp Arg Glu Gln Leu Arg Ala Asp Leu 
        675                 680                 685             
Leu Arg Glu Arg Glu Ala Arg Glu His Leu Glu Lys Val Val Lys Glu 
    690                 695                 700                 
Leu Gln Glu Gln Leu Trp Pro Arg Ala Arg Pro Glu Ala Ala Gly Ser 
705                 710                 715                 720 
Glu Gly Ala Ala Glu Leu Glu Pro 
                725             

<210>  45
<211>  2187
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  45
atggaggcgg cggcaggcgg ccgcggctgt ttccagccgc acccggggct gcagaagacg        60
ctggagcagt tccacctgag ctccatgagc tcgctgggcg gcccggccgc tttctcggcg       120
cgctgggcgc aggaggccta caagaaggag agcgccaagg aggcgggcgc ggccgcggtg       180
ccggcgccgg tgcccgcagc caccgagccg ccgcccgtgc tgcacctgcc cgccatccag       240
ccgccgccgc ccgtgctgcc cgggcccttc ttcatgccgt ccgaccgctc caccgagcgc       300
tgcgagaccg tactggaagg cgagaccatc tcgtgcttcg tggtgggagg cgagaagcgc       360
ctgtgtctgc cgcagattct caactcggtg ctgcgcgact tctcgctgca gcagatcaac       420
gcggtgtgcg acgagctcca catctactgc tcgcgctgca cggccgacca gctggagatc       480
ctcaaagtca tgggcatcct gcccttctcg gcgccctcgt gcgggctcat caccaagacg       540
gacgccgagc gcctgtgcaa cgcgctgctc tacggcggcg cctacccgcc gccctgcaag       600
aaggagctgg ccgccagcct ggcgctgggc ctggagctca gcgagcgcag cgtccgcgtg       660
taccacgagt gcttcggcaa gtgtaagggg ctgctggtgc ccgagctcta cagcagcccg       720
agcgccgcct gcatccagtg cctggactgc cgcctcatgt acccgccgca caagttcgtg       780
gtgcactcgc acaaggccct ggagaaccgg acctgccact ggggcttcga ctcggccaac       840
tggcgggcct acatcctgct gagccaggat tacacgggca aggaggagca ggcgcgcctc       900
ggccgctgcc tggacgacgt gaaggagaaa ttcgactatg gcaacaagta caagcggcgg       960
gtgccccggg tctcctctga gcctccggcc tccataagac ccaaaacaga tgacacctct      1020
tcccagtccc ccgcgccttc cgaaaaggac aagccgtcca gctggctgcg gaccttggcc      1080
ggctcttcca ataagagcct gggctgtgtt caccctcgcc agcgcctctc tgctttccga      1140
ccctggtccc ccgcagtgtc agcgagtgag aaagagctct ccccacacct cccggccctc      1200
atccgagaca gcttctactc ctacaagagc tttgagacag ccgtggcgcc caacgtggcc      1260
ctcgcaccgc cggcccagca gaaggttgtg agcagccctc cgtgtgccgc cgccgtctcc      1320
cgggcccccg agcctctcgc cacttgcacc cagcctcgga agcggaagct gactgtggac      1380
accccaggag ccccagagac gctggcgccc gtggctgccc cagaggagga caaggactcg      1440
gaggcggagg tggaagttga aagcagggag gaattcacct cctccttgtc ctcgctctct      1500
tccccgtcct ttacctcatc cagctccgcc aaggacctgg gctccccggg tgcgcgtgcc      1560
ctgccctcgg ccgtccctga tgctgcggcc cctgccgacg cccccagtgg gctggaggcg      1620
gagctggagc acctgcggca ggcactggag ggcggcctgg acaccaagga agccaaagag      1680
aagttcctgc atgaggtggt caagatgcgc gtgaagcagg aggagaagct cagcgcagcc      1740
ctgcaggcca agcgcagcct ccaccaggag ctggagttcc tacgcgtggc caagaaggag      1800
aagctgcggg aggccacgga ggccaagcgt aacctgcgga aggagatcga gcgtctccgc      1860
gccgagaacg agaagaagat gaaagaggcc aacgagtcac ggctgcgcct gaagcgggag      1920
ctggagcagg cgcggcaggc ccgggtgtgc gacaagggct gcgaggcggg ccgcctgcgc      1980
gccaagtact cggcccagat cgaagacctg caggtgaagc tgcagcacgc ggaggcggac      2040
cgggagcagc tgcgggccga cctgctgcgg gagcgcgagg cccgggagca cctggagaag      2100
gtggtgaagg agctgcagga acagctgtgg ccgcgggccc gccccgaggc tgcgggcagc      2160
gagggcgctg cggagctgga gccgtag                                          2187

<210>  48
<211>  352
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  48
Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      
Ser Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser 
            20                  25                  30          
Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser 
        35                  40                  45              
Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser 
    50                  55                  60                  
Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys 
65                  70                  75                  80  
Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu 
                85                  90                  95      
Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly 
            100                 105                 110         
Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn 
        115                 120                 125             
Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp 
    130                 135                 140                 
Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn 
145                 150                 155                 160 
Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser 
                165                 170                 175     
Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala 
            180                 185                 190         
Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val 
        195                 200                 205             
Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn 
    210                 215                 220                 
Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile 
225                 230                 235                 240 
Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr 
                245                 250                 255     
Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly 
            260                 265                 270         
Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn 
        275                 280                 285             
Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys 
    290                 295                 300                 
His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys 
305                 310                 315                 320 
Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly 
                325                 330                 335     
Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
            340                 345                 350         

<210>  49
<211>  1059
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  49
atgtggctgc agagcctgct gctcttgggc actgtggcct gcagcatctc tcgcaaagtg        60
tgtaacggaa taggtattgg tgaatttaaa gactcactct ccataaatgc tacgaatatt       120
aaacacttca aaaactgcac ctccatcagt ggcgatctcc acatcctgcc ggtggcattt       180
aggggtgact ccttcacaca tactcctcct ctggatccac aggaactgga tattctgaaa       240
accgtaaagg aaatcacagg gtttttgctg attcaggctt ggcctgaaaa caggacggac       300
ctccatgcct ttgagaacct agaaatcata cgcggcagga ccaagcaaca tggtcagttt       360
tctcttgcag tcgtcagcct gaacataaca tccttgggat tacgctccct caaggagata       420
agtgatggag atgtgataat ttcaggaaac aaaaatttgt gctatgcaaa tacaataaac       480
tggaaaaaac tgtttgggac ctccggtcag aaaaccaaaa ttataagcaa cagaggtgaa       540
aacagctgca aggccacagg ccaggtctgc catgccttgt gctcccccga gggctgctgg       600
ggcccggagc ccagggactg cgtctcttgc cggaatgtca gccgaggcag ggaatgcgtg       660
gacaagtgca accttctgga gggtgagcca agggagtttg tggagaactc tgagtgcata       720
cagtgccacc cagagtgcct gcctcaggcc atgaacatca cctgcacagg acggggacca       780
gacaactgta tccagtgtgc ccactacatt gacggccccc actgcgtcaa gacctgcccg       840
gcaggagtca tgggagaaaa caacaccctg gtctggaagt acgcagacgc cggccatgtg       900
tgccacctgt gccatccaaa ctgcacctac ggatgcactg ggccaggtct tgaaggctgt       960
ccaacgaatg ggcctaagat cccgtccatc gccactggga tggtgggggc cctcctcttg      1020
ctgctggtgg tggccctggg gatcggcctc ttcatgtaa                             1059

<210>  50
<211>  162
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  50
Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      
Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          
Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  
Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  
Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      
Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         
Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             
Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 
Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 
Thr Ser 
        

<210>  51
<211>  489
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  51
atgagaattt cgaaaccaca tttgagaagt atttccatcc agtgctactt gtgtttactt        60
ctaaacagtc attttctaac tgaagctggc attcatgtct tcattttggg ctgtttcagt       120
gcagggcttc ctaaaacaga agccaactgg gtgaatgtaa taagtgattt gaaaaaaatt       180
gaagacctta ttcaatctat gcatattgat gctactttat atacggaaag tgatgttcac       240
cccagttgca aagtaacagc aatgaagtgc tttctcttgg agttacaagt tatttcactt       300
gagtccggag atgcaagtat tcatgataca gtagaaaatc tgatcatcct agcaaacaac       360
agtttgtctt ctaatgggaa tgtaacagaa tctggatgca aagaatgtga ggaactggag       420
gaaaaaaata ttaaagaatt tttgcagagt tttgtacata ttgtccaaat gttcatcaac       480
acttcttga                                                               489

<210>  52
<211>  162
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  52
Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      
Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          
Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              
Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  
Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  
Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      
Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         
Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             
Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 
Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 
Asp Ser 
        

<210>  53
<211>  489
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  53
atgagatcca gtcctggcaa catggagagg attgtcatct gtctgatggt catcttcttg        60
gggacactgg tccacaaatc aagctcccaa ggtcaagatc gccacatgat tagaatgcgt       120
caacttatag atattgttga tcagctgaaa aattatgtga atgacttggt ccctgaattt       180
ctgccagctc cagaagatgt agagacaaac tgtgagtggt cagctttttc ctgctttcag       240
aaggcccaac taaagtcagc aaatacagga aacaatgaaa ggataatcaa tgtatcaatt       300
aaaaagctga agaggaaacc accttccaca aatgcaggga gaagacagaa acacagacta       360
acatgccctt catgtgattc ttatgagaaa aaaccaccca aagaattcct agaaagattc       420
aaatcacttc tccaaaagat gattcatcag catctgtcct ctagaacaca cggaagtgaa       480
gattcctga                                                               489

<210>  54
<211>  210
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  54
Met Pro Pro Tyr Thr Val Val Tyr Phe Pro Val Arg Gly Arg Cys Ala 
1               5                   10                  15      
Ala Leu Arg Met Leu Leu Ala Asp Gln Gly Gln Ser Trp Lys Glu Glu 
            20                  25                  30          
Val Val Thr Val Glu Thr Trp Gln Glu Gly Ser Leu Lys Ala Ser Cys 
        35                  40                  45              
Leu Tyr Gly Gln Leu Pro Lys Phe Gln Asp Gly Asp Leu Thr Leu Tyr 
    50                  55                  60                  
Gln Ser Asn Thr Ile Leu Arg His Leu Gly Arg Thr Leu Gly Leu Tyr 
65                  70                  75                  80  
Gly Lys Asp Gln Gln Glu Ala Ala Leu Val Asp Met Val Asn Asp Gly 
                85                  90                  95      
Val Glu Asp Leu Arg Cys Lys Tyr Ile Ser Leu Ile Tyr Thr Asn Tyr 
            100                 105                 110         
Glu Ala Gly Lys Asp Asp Tyr Val Lys Ala Leu Pro Gly Gln Leu Lys 
        115                 120                 125             
Pro Phe Glu Thr Leu Leu Ser Gln Asn Gln Gly Gly Lys Thr Phe Ile 
    130                 135                 140                 
Val Gly Asp Gln Ile Ser Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu 
145                 150                 155                 160 
Leu Ile His Glu Val Leu Ala Pro Gly Cys Leu Asp Ala Phe Pro Leu 
                165                 170                 175     
Leu Ser Ala Tyr Val Gly Arg Leu Ser Ala Arg Pro Lys Leu Lys Ala 
            180                 185                 190         
Phe Leu Ala Ser Pro Glu Tyr Val Asn Leu Pro Ile Asn Gly Asn Gly 
        195                 200                 205             
Lys Gln 
    210 

<210>  55
<211>  633
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  55
atgccgccct acaccgtggt ctatttccca gttcgaggcc gctgcgcggc cctgcgcatg        60
ctgctggcag atcagggcca gagctggaag gaggaggtgg tgaccgtgga gacgtggcag       120
gagggctcac tcaaagcctc ctgcctatac gggcagctcc ccaagttcca ggacggagac       180
ctcaccctgt accagtccaa taccatcctg cgtcacctgg gccgcaccct tgggctctat       240
gggaaggacc agcaggaggc agccctggtg gacatggtga atgacggcgt ggaggacctc       300
cgctgcaaat acatctccct catctacacc aactatgagg cgggcaagga tgactatgtg       360
aaggcactgc ccgggcaact gaagcctttt gagaccctgc tgtcccagaa ccagggaggc       420
aagaccttca ttgtgggaga ccagatctcc ttcgctgact acaacctgct ggacttgctg       480
ctgatccatg aggtcctagc ccctggctgc ctggatgcgt tccccctgct ctcagcatat       540
gtggggcgcc tcagtgcccg gcccaagctc aaggccttcc tggcctcccc tgagtacgtg       600
aacctcccca tcaatggcaa cgggaaacag tga                                    633

<210>  56
<211>  1234
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  56
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Glu Val Gln Leu Phe Gln Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Gly Val Gly Arg Gly Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             
Gly Thr Thr Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser 
145                 150                 155                 160 
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                165                 170                 175     
Ser Gln Ser Ile Ser Ile Tyr Leu Asn Trp Tyr Arg Gln Gln Pro Gly 
            180                 185                 190         
Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
        195                 200                 205             
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln 
225                 230                 235                 240 
Gln Thr Tyr Ser Thr Pro Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
                245                 250                 255     
Asp Ile Lys Thr Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            260                 265                 270         
Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        275                 280                 285             
Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    290                 295                 300                 
Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
305                 310                 315                 320 
Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
                325                 330                 335     
Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            340                 345                 350         
Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        355                 360                 365             
Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 
Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 
Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     
Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             
Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 
Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 
Pro Pro Arg Ala Cys Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
                485                 490                 495     
Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Ala Ala Ala Gly 
            500                 505                 510         
Gly Arg Gly Cys Phe Gln Pro His Pro Gly Leu Gln Lys Thr Leu Glu 
        515                 520                 525             
Gln Phe His Leu Ser Ser Met Ser Ser Leu Gly Gly Pro Ala Ala Phe 
    530                 535                 540                 
Ser Ala Arg Trp Ala Gln Glu Ala Tyr Lys Lys Glu Ser Ala Lys Glu 
545                 550                 555                 560 
Ala Gly Ala Ala Ala Val Pro Ala Pro Val Pro Ala Ala Thr Glu Pro 
                565                 570                 575     
Pro Pro Val Leu His Leu Pro Ala Ile Gln Pro Pro Pro Pro Val Leu 
            580                 585                 590         
Pro Gly Pro Phe Phe Met Pro Ser Asp Arg Ser Thr Glu Arg Cys Glu 
        595                 600                 605             
Thr Val Leu Glu Gly Glu Thr Ile Ser Cys Phe Val Val Gly Gly Glu 
    610                 615                 620                 
Lys Arg Leu Cys Leu Pro Gln Ile Leu Asn Ser Val Leu Arg Asp Phe 
625                 630                 635                 640 
Ser Leu Gln Gln Ile Asn Ala Val Cys Asp Glu Leu His Ile Tyr Cys 
                645                 650                 655     
Ser Arg Cys Thr Ala Asp Gln Leu Glu Ile Leu Lys Val Met Gly Ile 
            660                 665                 670         
Leu Pro Phe Ser Ala Pro Ser Cys Gly Leu Ile Thr Lys Thr Asp Ala 
        675                 680                 685             
Glu Arg Leu Cys Asn Ala Leu Leu Tyr Gly Gly Ala Tyr Pro Pro Pro 
    690                 695                 700                 
Cys Lys Lys Glu Leu Ala Ala Ser Leu Ala Leu Gly Leu Glu Leu Ser 
705                 710                 715                 720 
Glu Arg Ser Val Arg Val Tyr His Glu Cys Phe Gly Lys Cys Lys Gly 
                725                 730                 735     
Leu Leu Val Pro Glu Leu Tyr Ser Ser Pro Ser Ala Ala Cys Ile Gln 
            740                 745                 750         
Cys Leu Asp Cys Arg Leu Met Tyr Pro Pro His Lys Phe Val Val His 
        755                 760                 765             
Ser His Lys Ala Leu Glu Asn Arg Thr Cys His Trp Gly Phe Asp Ser 
    770                 775                 780                 
Ala Asn Trp Arg Ala Tyr Ile Leu Leu Ser Gln Asp Tyr Thr Gly Lys 
785                 790                 795                 800 
Glu Glu Gln Ala Arg Leu Gly Arg Cys Leu Asp Asp Val Lys Glu Lys 
                805                 810                 815     
Phe Asp Tyr Gly Asn Lys Tyr Lys Arg Arg Val Pro Arg Val Ser Ser 
            820                 825                 830         
Glu Pro Pro Ala Ser Ile Arg Pro Lys Thr Asp Asp Thr Ser Ser Gln 
        835                 840                 845             
Ser Pro Ala Pro Ser Glu Lys Asp Lys Pro Ser Ser Trp Leu Arg Thr 
    850                 855                 860                 
Leu Ala Gly Ser Ser Asn Lys Ser Leu Gly Cys Val His Pro Arg Gln 
865                 870                 875                 880 
Arg Leu Ser Ala Phe Arg Pro Trp Ser Pro Ala Val Ser Ala Ser Glu 
                885                 890                 895     
Lys Glu Leu Ser Pro His Leu Pro Ala Leu Ile Arg Asp Ser Phe Tyr 
            900                 905                 910         
Ser Tyr Lys Ser Phe Glu Thr Ala Val Ala Pro Asn Val Ala Leu Ala 
        915                 920                 925             
Pro Pro Ala Gln Gln Lys Val Val Ser Ser Pro Pro Cys Ala Ala Ala 
    930                 935                 940                 
Val Ser Arg Ala Pro Glu Pro Leu Ala Thr Cys Thr Gln Pro Arg Lys 
945                 950                 955                 960 
Arg Lys Leu Thr Val Asp Thr Pro Gly Ala Pro Glu Thr Leu Ala Pro 
                965                 970                 975     
Val Ala Ala Pro Glu Glu Asp Lys Asp Ser Glu Ala Glu Val Glu Val 
            980                 985                 990         
Glu Ser Arg Glu Glu Phe Thr Ser  Ser Leu Ser Ser Leu  Ser Ser Pro 
        995                 1000                 1005             
Ser Phe  Thr Ser Ser Ser Ser  Ala Lys Asp Leu Gly  Ser Pro Gly Ala 
    1010                 1015                 1020                 
Arg  Ala Leu Pro Ser Ala  Val Pro Asp Ala Ala  Ala Pro Ala Asp Ala  
1025                 1030                 1035                 1040 
Pro Ser Gly Leu Glu  Ala Glu Leu Glu His  Leu Arg Gln Ala Leu  Glu 
                1045                 1050                 1055     
Gly Gly Leu Asp  Thr Lys Glu Ala Lys  Glu Lys Phe Leu His  Glu Val 
            1060                 1065                 1070         
Val Lys Met  Arg Val Lys Gln Glu  Glu Lys Leu Ser Ala  Ala Leu Gln 
        1075                 1080                 1085             
Ala Lys  Arg Ser Leu His Gln  Glu Leu Glu Phe Leu  Arg Val Ala Lys 
    1090                 1095                 1100                 
Lys  Glu Lys Leu Arg Glu  Ala Thr Glu Ala Lys  Arg Asn Leu Arg Lys  
1105                 1110                 1115                 1120 
Glu Ile Glu Arg Leu  Arg Ala Glu Asn Glu  Lys Lys Met Lys Glu  Ala 
                1125                 1130                 1135     
Asn Glu Ser Arg  Leu Arg Leu Lys Arg  Glu Leu Glu Gln Ala  Arg Gln 
            1140                 1145                 1150         
Ala Arg Val  Cys Asp Lys Gly Cys  Glu Ala Gly Arg Leu  Arg Ala Lys 
        1155                 1160                 1165             
Tyr Ser  Ala Gln Ile Glu Asp  Leu Gln Val Lys Leu  Gln His Ala Glu 
    1170                 1175                 1180                 
Ala  Asp Arg Glu Gln Leu  Arg Ala Asp Leu Leu  Arg Glu Arg Glu Ala  
1185                 1190                 1195                 1200 
Arg Glu His Leu Glu  Lys Val Val Lys Glu  Leu Gln Glu Gln Leu  Trp 
                1205                 1210                 1215     
Pro Arg Ala Arg  Pro Glu Ala Ala Gly  Ser Glu Gly Ala Ala  Glu Leu 
            1220                 1225                 1230         
Glu Pro 
        

<210>  57
<211>  3705
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  57
atggaatttg gcctgagctg gctgtttctg gtggcgattc tgaaaggcgt gcagtgcgag        60
gtgcagctgt tccagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc       120
tgtgcagcct ctggattcac ctttagcagc tatgccatga gctgggtccg ccaggctcca       180
gggaaggggc tggagtgggt ctcagctatt agtggtagtg gtggtagcac atactacgca       240
gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg       300
caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgccag gggtgttggc       360
cggggctttg actactgggg ccaggggacc acggtcaccg tctcctcaag tggcggtggc       420
tctggcggtg gtgggtcggg tggcggcgga tcagacatcc agttgaccca gtctccatcc       480
tccctgtctg catctgtagg agacagagtc accatcactt gccgggcaag tcagagcatt       540
agcatctatt taaattggta tcggcagcaa ccagggaaag cccctaagct cctgatctat       600
gctgcatcca gtttgcaaag tggggtccca tcaaggttca gtggcagtgg atctgggaca       660
gatttcactc tcaccatcag cagtctgcaa cctgaagatt ttgcaactta cttctgtcaa       720
cagacttaca gtacccctcc gtggacgttc ggccaaggga ccaaagtgga tatcaaaacg       780
cgtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc       840
ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg       900
ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt       960
ctcctgtcac tggttatcac cctttactgc aggagtaaga ggagcaggct cctgcacagt      1020
gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat      1080
gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac      1140
gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      1200
gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg      1260
agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      1320
gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt      1380
taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg      1440
ccccctcgcg catgcggatc tggagagggc agaggaagtc ttctaacatg cggtgacgtg      1500
gaggagaatc ccggccctat ggaggcggcg gcaggcggcc gcggctgttt ccagccgcac      1560
ccggggctgc agaagacgct ggagcagttc cacctgagct ccatgagctc gctgggcggc      1620
ccggccgctt tctcggcgcg ctgggcgcag gaggcctaca agaaggagag cgccaaggag      1680
gcgggcgcgg ccgcggtgcc ggcgccggtg cccgcagcca ccgagccgcc gcccgtgctg      1740
cacctgcccg ccatccagcc gccgccgccc gtgctgcccg ggcccttctt catgccgtcc      1800
gaccgctcca ccgagcgctg cgagaccgta ctggaaggcg agaccatctc gtgcttcgtg      1860
gtgggaggcg agaagcgcct gtgtctgccg cagattctca actcggtgct gcgcgacttc      1920
tcgctgcagc agatcaacgc ggtgtgcgac gagctccaca tctactgctc gcgctgcacg      1980
gccgaccagc tggagatcct caaagtcatg ggcatcctgc ccttctcggc gccctcgtgc      2040
gggctcatca ccaagacgga cgccgagcgc ctgtgcaacg cgctgctcta cggcggcgcc      2100
tacccgccgc cctgcaagaa ggagctggcc gccagcctgg cgctgggcct ggagctcagc      2160
gagcgcagcg tccgcgtgta ccacgagtgc ttcggcaagt gtaaggggct gctggtgccc      2220
gagctctaca gcagcccgag cgccgcctgc atccagtgcc tggactgccg cctcatgtac      2280
ccgccgcaca agttcgtggt gcactcgcac aaggccctgg agaaccggac ctgccactgg      2340
ggcttcgact cggccaactg gcgggcctac atcctgctga gccaggatta cacgggcaag      2400
gaggagcagg cgcgcctcgg ccgctgcctg gacgacgtga aggagaaatt cgactatggc      2460
aacaagtaca agcggcgggt gccccgggtc tcctctgagc ctccggcctc cataagaccc      2520
aaaacagatg acacctcttc ccagtccccc gcgccttccg aaaaggacaa gccgtccagc      2580
tggctgcgga ccttggccgg ctcttccaat aagagcctgg gctgtgttca ccctcgccag      2640
cgcctctctg ctttccgacc ctggtccccc gcagtgtcag cgagtgagaa agagctctcc      2700
ccacacctcc cggccctcat ccgagacagc ttctactcct acaagagctt tgagacagcc      2760
gtggcgccca acgtggccct cgcaccgccg gcccagcaga aggttgtgag cagccctccg      2820
tgtgccgccg ccgtctcccg ggcccccgag cctctcgcca cttgcaccca gcctcggaag      2880
cggaagctga ctgtggacac cccaggagcc ccagagacgc tggcgcccgt ggctgcccca      2940
gaggaggaca aggactcgga ggcggaggtg gaagttgaaa gcagggagga attcacctcc      3000
tccttgtcct cgctctcttc cccgtccttt acctcatcca gctccgccaa ggacctgggc      3060
tccccgggtg cgcgtgccct gccctcggcc gtccctgatg ctgcggcccc tgccgacgcc      3120
cccagtgggc tggaggcgga gctggagcac ctgcggcagg cactggaggg cggcctggac      3180
accaaggaag ccaaagagaa gttcctgcat gaggtggtca agatgcgcgt gaagcaggag      3240
gagaagctca gcgcagccct gcaggccaag cgcagcctcc accaggagct ggagttccta      3300
cgcgtggcca agaaggagaa gctgcgggag gccacggagg ccaagcgtaa cctgcggaag      3360
gagatcgagc gtctccgcgc cgagaacgag aagaagatga aagaggccaa cgagtcacgg      3420
ctgcgcctga agcgggagct ggagcaggcg cggcaggccc gggtgtgcga caagggctgc      3480
gaggcgggcc gcctgcgcgc caagtactcg gcccagatcg aagacctgca ggtgaagctg      3540
cagcacgcgg aggcggaccg ggagcagctg cgggccgacc tgctgcggga gcgcgaggcc      3600
cgggagcacc tggagaaggt ggtgaaggag ctgcaggaac agctgtggcc gcgggcccgc      3660
cccgaggctg cgggcagcga gggcgctgcg gagctggagc cgtag                      3705

<210>  58
<211>  670
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  58
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Glu Val Gln Leu Phe Gln Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Gly Val Gly Arg Gly Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             
Gly Thr Thr Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser 
145                 150                 155                 160 
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                165                 170                 175     
Ser Gln Ser Ile Ser Ile Tyr Leu Asn Trp Tyr Arg Gln Gln Pro Gly 
            180                 185                 190         
Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
        195                 200                 205             
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln 
225                 230                 235                 240 
Gln Thr Tyr Ser Thr Pro Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
                245                 250                 255     
Asp Ile Lys Thr Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            260                 265                 270         
Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        275                 280                 285             
Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    290                 295                 300                 
Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
305                 310                 315                 320 
Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
                325                 330                 335     
Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            340                 345                 350         
Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        355                 360                 365             
Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 
Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 
Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     
Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             
Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 
Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 
Pro Pro Arg Ala Cys Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
                485                 490                 495     
Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Thr Met Arg Ile Ser 
            500                 505                 510         
Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr Leu Cys Leu Leu 
        515                 520                 525             
Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His Val Phe Ile Leu 
    530                 535                 540                 
Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn 
545                 550                 555                 560 
Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His 
                565                 570                 575     
Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys 
            580                 585                 590         
Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu 
        595                 600                 605             
Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile 
    610                 615                 620                 
Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly 
625                 630                 635                 640 
Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu 
                645                 650                 655     
Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
            660                 665                 670 

<210>  59
<211>  2013
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  59
atggaatttg gcctgagctg gctgtttctg gtggcgattc tgaaaggcgt gcagtgcgag        60
gtgcagctgt tccagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc       120
tgtgcagcct ctggattcac ctttagcagc tatgccatga gctgggtccg ccaggctcca       180
gggaaggggc tggagtgggt ctcagctatt agtggtagtg gtggtagcac atactacgca       240
gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg       300
caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgccag gggtgttggc       360
cggggctttg actactgggg ccaggggacc acggtcaccg tctcctcaag tggcggtggc       420
tctggcggtg gtgggtcggg tggcggcgga tcagacatcc agttgaccca gtctccatcc       480
tccctgtctg catctgtagg agacagagtc accatcactt gccgggcaag tcagagcatt       540
agcatctatt taaattggta tcggcagcaa ccagggaaag cccctaagct cctgatctat       600
gctgcatcca gtttgcaaag tggggtccca tcaaggttca gtggcagtgg atctgggaca       660
gatttcactc tcaccatcag cagtctgcaa cctgaagatt ttgcaactta cttctgtcaa       720
cagacttaca gtacccctcc gtggacgttc ggccaaggga ccaaagtgga tatcaaaacg       780
cgtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc       840
ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg       900
ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt       960
ctcctgtcac tggttatcac cctttactgc aggagtaaga ggagcaggct cctgcacagt      1020
gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat      1080
gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac      1140
gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      1200
gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg      1260
agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      1320
gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt      1380
taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg      1440
ccccctcgcg catgcggatc tggagagggc agaggaagtc ttctaacatg cggtgacgtg      1500
gaggagaatc ccggccctcg tacgatgaga atttcgaaac cacatttgag aagtatttcc      1560
atccagtgct acttgtgttt acttctaaac agtcattttc taactgaagc tggcattcat      1620
gtcttcattt tgggctgttt cagtgcaggg cttcctaaaa cagaagccaa ctgggtgaat      1680
gtaataagtg atttgaaaaa aattgaagac cttattcaat ctatgcatat tgatgctact      1740
ttatatacgg aaagtgatgt tcaccccagt tgcaaagtaa cagcaatgaa gtgctttctc      1800
ttggagttac aagttatttc acttgagtcc ggagatgcaa gtattcatga tacagtagaa      1860
aatctgatca tcctagcaaa caacagtttg tcttctaatg ggaatgtaac agaatctgga      1920
tgcaaagaat gtgaggaact ggaggaaaaa aatattaaag aatttttgca gagttttgta      1980
catattgtcc aaatgttcat caacacttct tga                                   2013

<210>  60
<211>  670
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  60
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Glu Val Gln Leu Phe Gln Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Gly Val Gly Arg Gly Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             
Gly Thr Thr Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser 
145                 150                 155                 160 
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                165                 170                 175     
Ser Gln Ser Ile Ser Ile Tyr Leu Asn Trp Tyr Arg Gln Gln Pro Gly 
            180                 185                 190         
Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
        195                 200                 205             
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln 
225                 230                 235                 240 
Gln Thr Tyr Ser Thr Pro Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
                245                 250                 255     
Asp Ile Lys Thr Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            260                 265                 270         
Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        275                 280                 285             
Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    290                 295                 300                 
Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
305                 310                 315                 320 
Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
                325                 330                 335     
Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            340                 345                 350         
Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        355                 360                 365             
Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 
Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 
Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     
Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             
Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 
Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 
Pro Pro Arg Ala Cys Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
                485                 490                 495     
Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Thr Met Arg Ser Ser 
            500                 505                 510         
Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met Val Ile Phe Leu 
        515                 520                 525             
Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln Asp Arg His Met 
    530                 535                 540                 
Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr 
545                 550                 555                 560 
Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu 
                565                 570                 575     
Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu 
            580                 585                 590         
Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile 
        595                 600                 605             
Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln 
    610                 615                 620                 
Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro 
625                 630                 635                 640 
Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile 
                645                 650                 655     
His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser 
            660                 665                 670 

<210>  61
<211>  2013
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  61
atggaatttg gcctgagctg gctgtttctg gtggcgattc tgaaaggcgt gcagtgcgag        60
gtgcagctgt tccagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc       120
tgtgcagcct ctggattcac ctttagcagc tatgccatga gctgggtccg ccaggctcca       180
gggaaggggc tggagtgggt ctcagctatt agtggtagtg gtggtagcac atactacgca       240
gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg       300
caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgccag gggtgttggc       360
cggggctttg actactgggg ccaggggacc acggtcaccg tctcctcaag tggcggtggc       420
tctggcggtg gtgggtcggg tggcggcgga tcagacatcc agttgaccca gtctccatcc       480
tccctgtctg catctgtagg agacagagtc accatcactt gccgggcaag tcagagcatt       540
agcatctatt taaattggta tcggcagcaa ccagggaaag cccctaagct cctgatctat       600
gctgcatcca gtttgcaaag tggggtccca tcaaggttca gtggcagtgg atctgggaca       660
gatttcactc tcaccatcag cagtctgcaa cctgaagatt ttgcaactta cttctgtcaa       720
cagacttaca gtacccctcc gtggacgttc ggccaaggga ccaaagtgga tatcaaaacg       780
cgtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc       840
ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg       900
ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt       960
ctcctgtcac tggttatcac cctttactgc aggagtaaga ggagcaggct cctgcacagt      1020
gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat      1080
gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac      1140
gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      1200
gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg      1260
agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      1320
gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt      1380
taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg      1440
ccccctcgcg catgcggatc tggagagggc agaggaagtc ttctaacatg cggtgacgtg      1500
gaggagaatc ccggccctcg tacgatgaga tccagtcctg gcaacatgga gaggattgtc      1560
atctgtctga tggtcatctt cttggggaca ctggtccaca aatcaagctc ccaaggtcaa      1620
gatcgccaca tgattagaat gcgtcaactt atagatattg ttgatcagct gaaaaattat      1680
gtgaatgact tggtccctga atttctgcca gctccagaag atgtagagac aaactgtgag      1740
tggtcagctt tttcctgctt tcagaaggcc caactaaagt cagcaaatac aggaaacaat      1800
gaaaggataa tcaatgtatc aattaaaaag ctgaagagga aaccaccttc cacaaatgca      1860
gggagaagac agaaacacag actaacatgc ccttcatgtg attcttatga gaaaaaacca      1920
cccaaagaat tcctagaaag attcaaatca cttctccaaa agatgattca tcagcatctg      1980
tcctctagaa cacacggaag tgaagattcc tga                                   2013

<210>  62
<211>  670
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  62
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Glu Val Gln Leu Phe Gln Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Gly Val Gly Arg Gly Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             
Gly Thr Thr Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser 
145                 150                 155                 160 
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                165                 170                 175     
Ser Gln Ser Ile Ser Ile Tyr Leu Asn Trp Tyr Arg Gln Gln Pro Gly 
            180                 185                 190         
Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
        195                 200                 205             
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln 
225                 230                 235                 240 
Gln Thr Tyr Ser Thr Pro Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
                245                 250                 255     
Asp Ile Lys Thr Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            260                 265                 270         
Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        275                 280                 285             
Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    290                 295                 300                 
Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
305                 310                 315                 320 
Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
                325                 330                 335     
Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            340                 345                 350         
Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        355                 360                 365             
Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 
Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 
Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     
Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             
Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 
Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 
Pro Pro Arg Ala Cys Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
                485                 490                 495     
Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Thr Met Arg Ile Ser 
            500                 505                 510         
Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr Leu Cys Leu Leu 
        515                 520                 525             
Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His Val Phe Ile Leu 
    530                 535                 540                 
Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn 
545                 550                 555                 560 
Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His 
                565                 570                 575     
Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys 
            580                 585                 590         
Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu 
        595                 600                 605             
Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile 
    610                 615                 620                 
Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly 
625                 630                 635                 640 
Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu 
                645                 650                 655     
Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
            660                 665                 670 

<210>  63
<211>  2013
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  63
atggaatttg gcctgagctg gctgtttctg gtggcgattc tgaaaggcgt gcagtgcgag        60
gtgcagctgt tccagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc       120
tgtgcagcct ctggattcac ctttagcagc tatgccatga gctgggtccg ccaggctcca       180
gggaaggggc tggagtgggt ctcagctatt agtggtagtg gtggtagcac atactacgca       240
gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg       300
caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgccag gggtgttggc       360
cggggctttg actactgggg ccaggggacc acggtcaccg tctcctcaag tggcggtggc       420
tctggcggtg gtgggtcggg tggcggcgga tcagacatcc agttgaccca gtctccatcc       480
tccctgtctg catctgtagg agacagagtc accatcactt gccgggcaag tcagagcatt       540
agcatctatt taaattggta tcggcagcaa ccagggaaag cccctaagct cctgatctat       600
gctgcatcca gtttgcaaag tggggtccca tcaaggttca gtggcagtgg atctgggaca       660
gatttcactc tcaccatcag cagtctgcaa cctgaagatt ttgcaactta cttctgtcaa       720
cagacttaca gtacccctcc gtggacgttc ggccaaggga ccaaagtgga tatcaaaacg       780
cgtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc       840
ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg       900
ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt       960
ctcctgtcac tggttatcac cctttactgc aggagtaaga ggagcaggct cctgcacagt      1020
gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat      1080
gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac      1140
gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      1200
gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg      1260
agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      1320
gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt      1380
taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg      1440
ccccctcgcg catgcggatc tggagagggc agaggaagtc ttctaacatg cggtgacgtg      1500
gaggagaatc ccggccctcg tacgatgaga atttcgaaac cacatttgag aagtatttcc      1560
atccagtgct acttgtgttt acttctaaac agtcattttc taactgaagc tggcattcat      1620
gtcttcattt tgggctgttt cagtgcaggg cttcctaaaa cagaagccaa ctgggtgaat      1680
gtaataagtg atttgaaaaa aattgaagac cttattcaat ctatgcatat tgatgctact      1740
ttatatacgg aaagtgatgt tcaccccagt tgcaaagtaa cagcaatgaa gtgctttctc      1800
ttggagttac aagttatttc acttgagtcc ggagatgcaa gtattcatga tacagtagaa      1860
aatctgatca tcctagcaaa caacagtttg tcttctaatg ggaatgtaac agaatctgga      1920
tgcaaagaat gtgaggaact ggaggaaaaa aatattaaag aatttttgca gagttttgta      1980
catattgtcc aaatgttcat caacacttct tga                                   2013

<210>  64
<211>  863
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  64
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Gly Phe Ser 
        35                  40                  45              
Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  
Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         
Tyr Cys Ala Lys Ala Leu Gly Ala Pro Val Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             
Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu 
145                 150                 155                 160 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
                165                 170                 175     
Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
            180                 185                 190         
Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro 
        195                 200                 205             
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
    210                 215                 220                 
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
225                 230                 235                 240 
Tyr Ser Thr Pro Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile 
                245                 250                 255     
Lys Thr Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         
Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             
Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
305                 310                 315                 320 
Ser Leu Val Ile Thr Leu Tyr Cys Arg Phe Ser Val Val Lys Arg Gly 
                325                 330                 335     
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             
Glu Glu Gly Gly Cys Glu Leu Arg Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 
Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 
Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     
Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         
Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             
Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 
Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 
His Met Gln Ala Leu Pro Pro Arg Ala Cys Gly Ser Gly Glu Gly Arg 
                485                 490                 495     
Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            500                 505                 510         
Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile Ser 
        515                 520                 525             
Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
    530                 535                 540                 
Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
545                 550                 555                 560 
Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
                565                 570                 575     
Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
            580                 585                 590         
Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
        595                 600                 605             
Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
    610                 615                 620                 
Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
625                 630                 635                 640 
Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
                645                 650                 655     
Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
            660                 665                 670         
Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
        675                 680                 685             
Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
    690                 695                 700                 
Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
705                 710                 715                 720 
Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
                725                 730                 735     
Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
            740                 745                 750         
Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
        755                 760                 765             
Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
    770                 775                 780                 
His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
785                 790                 795                 800 
Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
                805                 810                 815     
Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
            820                 825                 830         
Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
        835                 840                 845             
Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
    850                 855                 860             

<210>  65
<211>  2592
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  65
atggaatttg gcctgagctg gctgtttctg gtggcgattc tgaaaggcgt gcagtgcgtg        60
cagctggtgg agtctggggg aggcttggta cagcctgggg ggtccctgag actctcctgt       120
gcagcctctg gattcggttt tagtggctat gccatgagct gggtccgcca ggctccaggg       180
aaggggctgg agtgggtctc agctatcagt ggtagtggtg gtagcacata ctacgcagac       240
tccgtgaagg gccggttcac catctccaga gacaattcca agaacacgct gtatctgcaa       300
atgaacagcc tgagagccga ggacacggcc gtatattact gtgcgaaagc tctgggagca       360
ccagtctact ggggccaggg aacaatggtc accgtctcct caggtggcgg tggctcgggc       420
ggtggtgggt cgggtggcgg cggatcagac atcgtgatga cccagtctcc atcctccctg       480
tctgcatctg taggagacag agtcaccatc acttgccggg caagtcagag cattagcagc       540
tatttaaatt ggtatcagca gaaaccaggg aaagccccta agctcctgat ctatgctgca       600
tccagtttgc aaagtggggt cccatcaagg ttcagtggca gtggatctgg gacagatttc       660
actctcacca tcagcagtct gcaacctgaa gattttgcaa cttactactg tcaacagagt       720
tacagtaccc ctccgtggac gttcggccaa gggaccaaag tggatatcaa aacgcgtacc       780
acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc       840
ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac       900
ttcgcctgtg atatctacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg       960
tcactggtta tcacccttta ctgcaggttc agtgtcgtga agagaggccg gaagaagctg      1020
ctgtacatct tcaagcagcc tttcatgagg cccgtgcaga ctacccagga ggaagatgga      1080
tgcagctgta gattccctga agaggaggaa ggaggctgtg agctgagaag agtgaagttc      1140
agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc      1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag      1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa      1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag      1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt      1440
cacatgcagg ccctgccccc tcgcgcatgc ggatctggag agggcagagg aagtcttcta      1500
acatgcggtg acgtggagga gaatcccggc cctatgtggc tgcagagcct gctgctcttg      1560
ggcactgtgg cctgcagcat ctctcgcaaa gtgtgtaacg gaataggtat tggtgaattt      1620
aaagactcac tctccataaa tgctacgaat attaaacact tcaaaaactg cacctccatc      1680
agtggcgatc tccacatcct gccggtggca tttaggggtg actccttcac acatactcct      1740
cctctggatc cacaggaact ggatattctg aaaaccgtaa aggaaatcac agggtttttg      1800
ctgattcagg cttggcctga aaacaggacg gacctccatg cctttgagaa cctagaaatc      1860
atacgcggca ggaccaagca acatggtcag ttttctcttg cagtcgtcag cctgaacata      1920
acatccttgg gattacgctc cctcaaggag ataagtgatg gagatgtgat aatttcagga      1980
aacaaaaatt tgtgctatgc aaatacaata aactggaaaa aactgtttgg gacctccggt      2040
cagaaaacca aaattataag caacagaggt gaaaacagct gcaaggccac aggccaggtc      2100
tgccatgcct tgtgctcccc cgagggctgc tggggcccgg agcccaggga ctgcgtctct      2160
tgccggaatg tcagccgagg cagggaatgc gtggacaagt gcaaccttct ggagggtgag      2220
ccaagggagt ttgtggagaa ctctgagtgc atacagtgcc acccagagtg cctgcctcag      2280
gccatgaaca tcacctgcac aggacgggga ccagacaact gtatccagtg tgcccactac      2340
attgacggcc cccactgcgt caagacctgc ccggcaggag tcatgggaga aaacaacacc      2400
ctggtctgga agtacgcaga cgccggccat gtgtgccacc tgtgccatcc aaactgcacc      2460
tacggatgca ctgggccagg tcttgaaggc tgtccaacga atgggcctaa gatcccgtcc      2520
atcgccactg ggatggtggg ggccctcctc ttgctgctgg tggtggccct ggggatcggc      2580
ctcttcatgt aa                                                          2592

<210>  66
<211>  865
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  66
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Glu Val Gln Leu Phe Gln Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Gly Val Gly Arg Gly Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             
Gly Thr Thr Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser 
145                 150                 155                 160 
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                165                 170                 175     
Ser Gln Ser Ile Ser Ile Tyr Leu Asn Trp Tyr Arg Gln Gln Pro Gly 
            180                 185                 190         
Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
        195                 200                 205             
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln 
225                 230                 235                 240 
Gln Thr Tyr Ser Thr Pro Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
                245                 250                 255     
Asp Ile Lys Thr Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            260                 265                 270         
Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        275                 280                 285             
Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    290                 295                 300                 
Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
305                 310                 315                 320 
Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Phe Ser Val Val Lys 
                325                 330                 335     
Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         
Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             
Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Arg Val Lys Phe Ser Arg 
    370                 375                 380                 
Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 
Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     
Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         
Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             
Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 
Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 
Ala Leu His Met Gln Ala Leu Pro Pro Arg Ala Cys Gly Ser Gly Glu 
                485                 490                 495     
Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
            500                 505                 510         
Pro Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser 
        515                 520                 525             
Ile Ser Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp 
    530                 535                 540                 
Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr 
545                 550                 555                 560 
Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp 
                565                 570                 575     
Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu 
            580                 585                 590         
Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro 
        595                 600                 605             
Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg 
    610                 615                 620                 
Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu 
625                 630                 635                 640 
Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly 
                645                 650                 655     
Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile 
            660                 665                 670         
Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile 
        675                 680                 685             
Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His 
    690                 695                 700                 
Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys 
705                 710                 715                 720 
Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys 
                725                 730                 735     
Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys 
            740                 745                 750         
Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys 
        755                 760                 765             
Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp 
    770                 775                 780                 
Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn 
785                 790                 795                 800 
Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu 
                805                 810                 815     
Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly 
            820                 825                 830         
Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val 
        835                 840                 845             
Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe 
    850                 855                 860                 
Met 
865 

<210>  67
<211>  2598
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  67
atggaatttg gcctgagctg gctgtttctg gtggcgattc tgaaaggcgt gcagtgcgag        60
gtgcagctgt tccagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc       120
tgtgcagcct ctggattcac ctttagcagc tatgccatga gctgggtccg ccaggctcca       180
gggaaggggc tggagtgggt ctcagctatt agtggtagtg gtggtagcac atactacgca       240
gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg       300
caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgccag gggtgttggc       360
cggggctttg actactgggg ccaggggacc acggtcaccg tctcctcaag tggcggtggc       420
tctggcggtg gtgggtcggg tggcggcgga tcagacatcc agttgaccca gtctccatcc       480
tccctgtctg catctgtagg agacagagtc accatcactt gccgggcaag tcagagcatt       540
agcatctatt taaattggta tcggcagcaa ccagggaaag cccctaagct cctgatctat       600
gctgcatcca gtttgcaaag tggggtccca tcaaggttca gtggcagtgg atctgggaca       660
gatttcactc tcaccatcag cagtctgcaa cctgaagatt ttgcaactta cttctgtcaa       720
cagacttaca gtacccctcc gtggacgttc ggccaaggga ccaaagtgga tatcaaaacg       780
cgtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc       840
ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg       900
ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt       960
ctcctgtcac tggttatcac cctttactgc aggttcagtg tcgtgaagag aggccggaag      1020
aagctgctgt acatcttcaa gcagcctttc atgaggcccg tgcagactac ccaggaggaa      1080
gatggatgca gctgtagatt ccctgaagag gaggaaggag gctgtgagct gagaagagtg      1140
aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac      1200
gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac      1260
cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg      1320
cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg      1380
ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac      1440
gcccttcaca tgcaggccct gccccctcgc gcatgcggat ctggagaggg cagaggaagt      1500
cttctaacat gcggtgacgt ggaggagaat cccggcccta tgtggctgca gagcctgctg      1560
ctcttgggca ctgtggcctg cagcatctct cgcaaagtgt gtaacggaat aggtattggt      1620
gaatttaaag actcactctc cataaatgct acgaatatta aacacttcaa aaactgcacc      1680
tccatcagtg gcgatctcca catcctgccg gtggcattta ggggtgactc cttcacacat      1740
actcctcctc tggatccaca ggaactggat attctgaaaa ccgtaaagga aatcacaggg      1800
tttttgctga ttcaggcttg gcctgaaaac aggacggacc tccatgcctt tgagaaccta      1860
gaaatcatac gcggcaggac caagcaacat ggtcagtttt ctcttgcagt cgtcagcctg      1920
aacataacat ccttgggatt acgctccctc aaggagataa gtgatggaga tgtgataatt      1980
tcaggaaaca aaaatttgtg ctatgcaaat acaataaact ggaaaaaact gtttgggacc      2040
tccggtcaga aaaccaaaat tataagcaac agaggtgaaa acagctgcaa ggccacaggc      2100
caggtctgcc atgccttgtg ctcccccgag ggctgctggg gcccggagcc cagggactgc      2160
gtctcttgcc ggaatgtcag ccgaggcagg gaatgcgtgg acaagtgcaa ccttctggag      2220
ggtgagccaa gggagtttgt ggagaactct gagtgcatac agtgccaccc agagtgcctg      2280
cctcaggcca tgaacatcac ctgcacagga cggggaccag acaactgtat ccagtgtgcc      2340
cactacattg acggccccca ctgcgtcaag acctgcccgg caggagtcat gggagaaaac      2400
aacaccctgg tctggaagta cgcagacgcc ggccatgtgt gccacctgtg ccatccaaac      2460
tgcacctacg gatgcactgg gccaggtctt gaaggctgtc caacgaatgg gcctaagatc      2520
ccgtccatcg ccactgggat ggtgggggcc ctcctcttgc tgctggtggt ggccctgggg      2580
atcggcctct tcatgtaa                                                    2598

<210>  68
<211>  716
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  68
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Glu Val Gln Leu Phe Gln Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Gly Val Gly Arg Gly Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             
Gly Thr Thr Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser 
145                 150                 155                 160 
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                165                 170                 175     
Ser Gln Ser Ile Ser Ile Tyr Leu Asn Trp Tyr Arg Gln Gln Pro Gly 
            180                 185                 190         
Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
        195                 200                 205             
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln 
225                 230                 235                 240 
Gln Thr Tyr Ser Thr Pro Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
                245                 250                 255     
Asp Ile Lys Thr Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            260                 265                 270         
Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        275                 280                 285             
Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    290                 295                 300                 
Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
305                 310                 315                 320 
Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
                325                 330                 335     
Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            340                 345                 350         
Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        355                 360                 365             
Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 
Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 
Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     
Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             
Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 
Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 
Pro Pro Arg Gly Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
                485                 490                 495     
Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro Pro Tyr Thr Val 
            500                 505                 510         
Val Tyr Phe Pro Val Arg Gly Arg Cys Ala Ala Leu Arg Met Leu Leu 
        515                 520                 525             
Ala Asp Gln Gly Gln Ser Trp Lys Glu Glu Val Val Thr Val Glu Thr 
    530                 535                 540                 
Trp Gln Glu Gly Ser Leu Lys Ala Ser Cys Leu Tyr Gly Gln Leu Pro 
545                 550                 555                 560 
Lys Phe Gln Asp Gly Asp Leu Thr Leu Tyr Gln Ser Asn Thr Ile Leu 
                565                 570                 575     
Arg His Leu Gly Arg Thr Leu Gly Leu Tyr Gly Lys Asp Gln Gln Glu 
            580                 585                 590         
Ala Ala Leu Val Asp Met Val Asn Asp Gly Val Glu Asp Leu Arg Cys 
        595                 600                 605             
Lys Tyr Ile Ser Leu Ile Tyr Thr Asn Tyr Glu Ala Gly Lys Asp Asp 
    610                 615                 620                 
Tyr Val Lys Ala Leu Pro Gly Gln Leu Lys Pro Phe Glu Thr Leu Leu 
625                 630                 635                 640 
Ser Gln Asn Gln Gly Gly Lys Thr Phe Ile Val Gly Asp Gln Ile Ser 
                645                 650                 655     
Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu Leu Ile His Glu Val Leu 
            660                 665                 670         
Ala Pro Gly Cys Leu Asp Ala Phe Pro Leu Leu Ser Ala Tyr Val Gly 
        675                 680                 685             
Arg Leu Ser Ala Arg Pro Lys Leu Lys Ala Phe Leu Ala Ser Pro Glu 
    690                 695                 700                 
Tyr Val Asn Leu Pro Ile Asn Gly Asn Gly Lys Gln 
705                 710                 715     

<210>  69
<211>  2151
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  69
atggaatttg gcctgagctg gctgtttctg gtggcgattc tgaaaggcgt gcagtgcgag        60
gtgcagctgt tccagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc       120
tgtgcagcct ctggattcac ctttagcagc tatgccatga gctgggtccg ccaggctcca       180
gggaaggggc tggagtgggt ctcagctatt agtggtagtg gtggtagcac atactacgca       240
gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg       300
caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgccag gggtgttggc       360
cggggctttg actactgggg ccaggggacc acggtcaccg tctcctcaag tggcggtggc       420
tctggcggtg gtgggtcggg tggcggcgga tcagacatcc agttgaccca gtctccatcc       480
tccctgtctg catctgtagg agacagagtc accatcactt gccgggcaag tcagagcatt       540
agcatctatt taaattggta tcggcagcaa ccagggaaag cccctaagct cctgatctat       600
gctgcatcca gtttgcaaag tggggtccca tcaaggttca gtggcagtgg atctgggaca       660
gatttcactc tcaccatcag cagtctgcaa cctgaagatt ttgcaactta cttctgtcaa       720
cagacttaca gtacccctcc gtggacgttc ggccaaggga ccaaagtgga tatcaaaacg       780
cgtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc       840
ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg       900
ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt       960
ctcctgtcac tggttatcac cctttactgc aggagtaaga ggagcaggct cctgcacagt      1020
gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat      1080
gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac      1140
gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      1200
gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg      1260
agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      1320
gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt      1380
taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg      1440
ccccctcgcg gatccggatc tggagagggc agaggaagtc ttctaacatg cggtgacgtg      1500
gaggagaatc ccggccctat gccgccctac accgtggtct atttcccagt tcgaggccgc      1560
tgcgcggccc tgcgcatgct gctggcagat cagggccaga gctggaagga ggaggtggtg      1620
accgtggaga cgtggcagga gggctcactc aaagcctcct gcctatacgg gcagctcccc      1680
aagttccagg acggagacct caccctgtac cagtccaata ccatcctgcg tcacctgggc      1740
cgcacccttg ggctctatgg gaaggaccag caggaggcag ccctggtgga catggtgaat      1800
gacggcgtgg aggacctccg ctgcaaatac atctccctca tctacaccaa ctatgaggcg      1860
ggcaaggatg actatgtgaa ggcactgccc gggcaactga agccttttga gaccctgctg      1920
tcccagaacc agggaggcaa gaccttcatt gtgggagacc agatctcctt cgctgactac      1980
aacctgctgg acttgctgct gatccatgag gtcctagccc ctggctgcct ggatgcgttc      2040
cccctgctct cagcatatgt ggggcgcctc agtgcccggc ccaagctcaa ggccttcctg      2100
gcctcccctg agtacgtgaa cctccccatc aatggcaacg ggaaacagtg a               2151

<210>  70
<211>  240
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  70
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Asn Ser His 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Val Ile Trp Tyr Asp Gly Ser Asn Ala Tyr Tyr Ala Asp Ser Ala 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Val Tyr 
65                  70                  75                  80  
Leu Gln Leu Asn Ser Leu Gly Val Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Ser Asp Arg Pro His Pro Met Gly Phe Tyr Tyr Tyr Met Asp 
            100                 105                 110         
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val 
    130                 135                 140                 
Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser 
145                 150                 155                 160 
Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro 
                165                 170                 175     
Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asn Arg Pro Ser 
            180                 185                 190         
Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
        195                 200                 205             
Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 
Ser Ser Tyr Thr Ser Ser Ser Thr Leu Val Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 

<210>  71
<211>  720
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  71
caggtgcagc tggtgcagag cggcggcggc gtggtgcagc cgggccgcag cctgcgcctg        60
agctgcagcg cgagcggctt tacctttaac agccatggca tgcattgggt gcgccaggcg       120
ccgggcaaag gcctggaatg ggtgggcgtg atttggtatg atggcagcaa cgcgtattat       180
gcggatagcg cgaaaggccg ctttaccatt agccgcgata acagcaaaaa cagcgtgtat       240
ctgcagctga acagcctggg cgtggaagat accgcgctgt attattgcgc gaaaagcgat       300
cgcccgcatc cgatgggctt ttattattat atggatgtgt ggggccaggg caccaccgtg       360
accgtgagca gcggcggcgg cggcagcggc ggcggcggca gccagagcgc gctgacccag       420
ccggcgagcg tgagcggcag cccgggccag agcattacca ttagctgcac cggcaccagc       480
agcgatgtgg gcggctataa ctatgtgagc tggtatcagc agcatccggg caaagcgccg       540
aaactgatga tttatgatgt gagcaaccgc ccgagcggcg tgagcaaccg ctttagcggc       600
agcaaaagcg gcaacaccgc gagcctgacc attagcggcc tgcaggcgga agatgaagcg       660
gattattatt gcagcagcta taccagcagc agcaccctgg tgtttggcgg cggcaccaaa       720

