                               SEQUENCE LISTING

<110> THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR 
      UNIVERSITY
 
<120> COMPOSITIONS AND METHODS FOR EFFICIENT RETRON RECRUITMENT TO DNA 
      BREAKS

<130> 079445-1330546-010210PC

<140> PCT/US2022/073130
<141> 2022-06-23

<150> 63/214,196
<151> 2021-06-23

<160> 11    

<170> PatentIn version 3.5

<210> 1
<211> 82
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
atgcgcaccc ttagcgagag gtttatcatt aaggtcaacc tctggatgtt gtttcggcat       60

cctgcattga atctgagtta ct                                                82


<210> 2
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
tctgagttac tgtctgtttt cct                                               23


<210> 3
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
aggaaacccg tttcttctga cgtaagggtg cgca                                   34


<210> 4
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Met Pro Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Ser 
1               5                   10              


<210> 5
<211> 129
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr Gly 
1               5                   10                  15      


Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu Trp 
            20                  25                  30          


Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser Val 
        35                  40                  45              


Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu Val 
    50                  55                  60                  


Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val Ala 
65                  70                  75                  80  


Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe Ala 
                85                  90                  95      


Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu Leu 
            100                 105                 110         


Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly Ile 
        115                 120                 125             


Tyr 
    


<210> 6
<211> 202
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Lys Ala Leu Thr Ala Arg Gln Gln Glu Val Phe Asp Leu Ile Arg 
1               5                   10                  15      


Asp His Ile Ser Gln Thr Gly Met Pro Pro Thr Arg Ala Glu Ile Ala 
            20                  25                  30          


Gln Arg Leu Gly Phe Arg Ser Pro Asn Ala Ala Glu Glu His Leu Lys 
        35                  40                  45              


Ala Leu Ala Arg Lys Gly Val Ile Glu Ile Val Ser Gly Ala Ser Arg 
    50                  55                  60                  


Gly Ile Arg Leu Leu Gln Glu Glu Glu Glu Gly Leu Pro Leu Val Gly 
65                  70                  75                  80  


Arg Val Ala Ala Gly Glu Pro Leu Leu Ala Gln Gln His Ile Glu Gly 
                85                  90                  95      


His Tyr Gln Val Asp Pro Ser Leu Phe Lys Pro Asn Ala Asp Phe Leu 
            100                 105                 110         


Leu Arg Val Ser Gly Met Ser Met Lys Asp Ile Gly Ile Met Asp Gly 
        115                 120                 125             


Asp Leu Leu Ala Val His Lys Thr Gln Asp Val Arg Asn Gly Gln Val 
    130                 135                 140                 


Val Val Ala Arg Ile Asp Asp Glu Val Thr Val Lys Arg Leu Lys Lys 
145                 150                 155                 160 


Gln Gly Asn Lys Val Glu Leu Leu Pro Glu Asn Ser Glu Phe Lys Pro 
                165                 170                 175     


Ile Val Val Asp Leu Arg Gln Gln Ser Phe Thr Ile Glu Gly Leu Ala 
            180                 185                 190         


Val Gly Val Ile Arg Asn Gly Asp Trp Leu 
        195                 200         


<210> 7
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Pro Lys Lys Lys Arg Lys Val Ala Ala Ala Gly Ser Gly 
            20                  25                  30      


<210> 8
<211> 230
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Ser Val Thr Ser Arg Glu Gln Lys Phe Ser Gly Lys Tyr Ser Ser 
1               5                   10                  15      


Tyr Thr Ala Gln Asp Arg Gln Gly Leu Val Asn Ala Val Thr Cys Val 
            20                  25                  30          


Leu Ser Ser Ser Ser Asp Pro Val Ala Val Ser Ser Asp Tyr Ser Asn 
        35                  40                  45              


Ser Leu Ser Ile Ala Arg Glu Val Asn Ala Tyr Ala Lys Ile Ala Gly 
    50                  55                  60                  


Cys Asp Trp Thr Tyr Tyr Val Gln Lys Leu Glu Val Thr Ile Gly Arg 
65                  70                  75                  80  


Asn Thr Asp Ser Leu Asn Leu Asn Ala Val Pro Gly Thr Val Val Lys 
                85                  90                  95      


Lys Asn Ile Asp Ile Asp Leu Gly Pro Ala Lys Ile Val Ser Arg Lys 
            100                 105                 110         


His Ala Ala Ile Arg Phe Asn Leu Glu Ser Gly Ser Trp Glu Leu Gln 
        115                 120                 125             


Ile Phe Gly Arg Asn Gly Ala Lys Val Asn Phe Arg Arg Ile Pro Thr 
    130                 135                 140                 


Gly Pro Asp Ser Pro Pro Thr Val Leu Gln Ser Gly Cys Ile Ile Asp 
145                 150                 155                 160 


Ile Gly Gly Val Gln Met Ile Phe Ile Leu Pro Glu Gln Glu Thr Ile 
                165                 170                 175     


Ile Ser Asp Tyr Cys Leu Asn His Leu Met Pro Lys Leu Leu Ser Thr 
            180                 185                 190         


Tyr Gly Thr Asn Gly Asn Asn Asn Pro Leu Leu Arg Asn Ile Ile Glu 
        195                 200                 205             


Gly Ser Thr Tyr Leu Arg Glu Gln Arg Leu Gln Glu Glu Ala Arg Leu 
    210                 215                 220                 


Gln Arg Leu Asp His Leu 
225                 230 


<210> 9
<211> 611
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Pro Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Ser Ala Ser Asn 
1               5                   10                  15      


Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr Gly Asp Val Thr 
            20                  25                  30          


Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu Trp Ile Ser Ser 
        35                  40                  45              


Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser Val Arg Gln Ser 
    50                  55                  60                  


Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu Val Pro Lys Val 
65                  70                  75                  80  


Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val Ala Ala Trp Arg 
                85                  90                  95      


Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe Ala Thr Asn Ser 
            100                 105                 110         


Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu Leu Lys Asp Gly 
        115                 120                 125             


Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly Ile Tyr Ser Ala 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Pro Lys Lys Lys Arg Lys Val Ala Ala Ala Gly Ser Gly Met Lys Ala 
                165                 170                 175     


Leu Thr Ala Arg Gln Gln Glu Val Phe Asp Leu Ile Arg Asp His Ile 
            180                 185                 190         


Ser Gln Thr Gly Met Pro Pro Thr Arg Ala Glu Ile Ala Gln Arg Leu 
        195                 200                 205             


Gly Phe Arg Ser Pro Asn Ala Ala Glu Glu His Leu Lys Ala Leu Ala 
    210                 215                 220                 


Arg Lys Gly Val Ile Glu Ile Val Ser Gly Ala Ser Arg Gly Ile Arg 
225                 230                 235                 240 


Leu Leu Gln Glu Glu Glu Glu Gly Leu Pro Leu Val Gly Arg Val Ala 
                245                 250                 255     


Ala Gly Glu Pro Leu Leu Ala Gln Gln His Ile Glu Gly His Tyr Gln 
            260                 265                 270         


Val Asp Pro Ser Leu Phe Lys Pro Asn Ala Asp Phe Leu Leu Arg Val 
        275                 280                 285             


Ser Gly Met Ser Met Lys Asp Ile Gly Ile Met Asp Gly Asp Leu Leu 
    290                 295                 300                 


Ala Val His Lys Thr Gln Asp Val Arg Asn Gly Gln Val Val Val Ala 
305                 310                 315                 320 


Arg Ile Asp Asp Glu Val Thr Val Lys Arg Leu Lys Lys Gln Gly Asn 
                325                 330                 335     


Lys Val Glu Leu Leu Pro Glu Asn Ser Glu Phe Lys Pro Ile Val Val 
            340                 345                 350         


Asp Leu Arg Gln Gln Ser Phe Thr Ile Glu Gly Leu Ala Val Gly Val 
        355                 360                 365             


Ile Arg Asn Gly Asp Trp Leu Glu Phe Pro Gly Ile Arg Met Ser Val 
    370                 375                 380                 


Thr Ser Arg Glu Gln Lys Phe Ser Gly Lys Tyr Ser Ser Tyr Thr Ala 
385                 390                 395                 400 


Gln Asp Arg Gln Gly Leu Val Asn Ala Val Thr Cys Val Leu Ser Ser 
                405                 410                 415     


Ser Ser Asp Pro Val Ala Val Ser Ser Asp Tyr Ser Asn Ser Leu Ser 
            420                 425                 430         


Ile Ala Arg Glu Val Asn Ala Tyr Ala Lys Ile Ala Gly Cys Asp Trp 
        435                 440                 445             


Thr Tyr Tyr Val Gln Lys Leu Glu Val Thr Ile Gly Arg Asn Thr Asp 
    450                 455                 460                 


Ser Leu Asn Leu Asn Ala Val Pro Gly Thr Val Val Lys Lys Asn Ile 
465                 470                 475                 480 


Asp Ile Asp Leu Gly Pro Ala Lys Ile Val Ser Arg Lys His Ala Ala 
                485                 490                 495     


Ile Arg Phe Asn Leu Glu Ser Gly Ser Trp Glu Leu Gln Ile Phe Gly 
            500                 505                 510         


Arg Asn Gly Ala Lys Val Asn Phe Arg Arg Ile Pro Thr Gly Pro Asp 
        515                 520                 525             


Ser Pro Pro Thr Val Leu Gln Ser Gly Cys Ile Ile Asp Ile Gly Gly 
    530                 535                 540                 


Val Gln Met Ile Phe Ile Leu Pro Glu Gln Glu Thr Ile Ile Ser Asp 
545                 550                 555                 560 


Tyr Cys Leu Asn His Leu Met Pro Lys Leu Leu Ser Thr Tyr Gly Thr 
                565                 570                 575     


Asn Gly Asn Asn Asn Pro Leu Leu Arg Asn Ile Ile Glu Gly Ser Thr 
            580                 585                 590         


Tyr Leu Arg Glu Gln Arg Leu Gln Glu Glu Ala Arg Leu Gln Arg Leu 
        595                 600                 605             


Asp His Leu 
    610     


<210> 10
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Pro Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Ser Ala Ser Asn 
1               5                   10                  15      


Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr Gly Asp Val Thr 
            20                  25                  30          


Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu Trp Ile Ser Ser 
        35                  40                  45              


Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser Val Arg Gln Ser 
    50                  55                  60                  


Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu Val Pro Lys Val 
65                  70                  75                  80  


Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val Ala Ala Trp Arg 
                85                  90                  95      


Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe Ala Thr Asn Ser 
            100                 105                 110         


Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu Leu Lys Asp Gly 
        115                 120                 125             


Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly Ile Tyr Ser Ala 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Pro Lys Lys Lys Arg Lys Val Ala Ala Ala Gly Ser Gly Ile Arg Met 
                165                 170                 175     


Ser Val Thr Ser Arg Glu Gln Lys Phe Ser Gly Lys Tyr Ser Ser Tyr 
            180                 185                 190         


Thr Ala Gln Asp Arg Gln Gly Leu Val Asn Ala Val Thr Cys Val Leu 
        195                 200                 205             


Ser Ser Ser Ser Asp Pro Val Ala Val Ser Ser Asp Tyr Ser Asn Ser 
    210                 215                 220                 


Leu Ser Ile Ala Arg Glu Val Asn Ala Tyr Ala Lys Ile Ala Gly Cys 
225                 230                 235                 240 


Asp Trp Thr Tyr Tyr Val Gln Lys Leu Glu Val Thr Ile Gly Arg Asn 
                245                 250                 255     


Thr Asp Ser Leu Asn Leu Asn Ala Val Pro Gly Thr Val Val Lys Lys 
            260                 265                 270         


Asn Ile Asp Ile Asp Leu Gly Pro Ala Lys Ile Val Ser Arg Lys His 
        275                 280                 285             


Ala Ala Ile Arg Phe Asn Leu Glu Ser Gly Ser Trp Glu Leu Gln Ile 
    290                 295                 300                 


Phe Gly Arg Asn Gly Ala Lys Val Asn Phe Arg Arg Ile Pro Thr Gly 
305                 310                 315                 320 


Pro Asp Ser Pro Pro Thr Val Leu Gln Ser Gly Cys Ile Ile Asp Ile 
                325                 330                 335     


Gly Gly Val Gln Met Ile Phe Ile Leu Pro Glu Gln Glu Thr Ile Ile 
            340                 345                 350         


Ser Asp Tyr Cys Leu Asn His Leu Met Pro Lys Leu Leu Ser Thr Tyr 
        355                 360                 365             


Gly Thr Asn Gly Asn Asn Asn Pro Leu Leu Arg Asn Ile Ile Glu Gly 
    370                 375                 380                 


Ser Thr Tyr Leu Arg Glu Gln Arg Leu Gln Glu Glu Ala Arg Leu Gln 
385                 390                 395                 400 


Arg Leu Asp His Leu 
                405 


<210> 11
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Tyr Ala Asp Asp 
1               


