                         SEQUENCE LISTING

<110>  Northwestern University
       Dmello, Crismita
       Sonabend Worthalter, Adam
       Sonabend, Aaron
       Stupp, Roger
 
<120>  METHODS OF DETERMINING RESPONSIVENESS TO CHEMOTHERAPEUTIC 
       COMPOUNDS FOR CANCER THERAPY

<130>  702581.02181

<150>  63/202,761
<151>  2021-06-23

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- ERN1 1F

<400>  1
caccggagtc ctcgccatgc cggcc                                             25


<210>  2
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- ERN1 1R

<400>  2
aaacggccgg catggcgagg actcc                                             25


<210>  3
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- ERN1 2F

<400>  3
caccgcttgt tgtttgtgtc aacgc                                             25


<210>  4
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- ERN1 2R

<400>  4
aaacgcgttg acacaaacaa caagc                                             25


<210>  5
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- SSR3 1F

<400>  5
caccgaggac ttggccgaga gattg                                             25


<210>  6
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- SSR3 1R

<400>  6
aaaccaatct ctcggccaag tcctc                                             25


<210>  7
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- SSR3 2F

<400>  7
caccgctcca aacagcagtc tgagg                                             25


<210>  8
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- SSR3 2R

<400>  8
aaaccctcag actgctgttt ggagc                                             25


<210>  9
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- IRAK4 1F

<400>  9
caccgcctgg gagcaaaaga ctcgc                                             25


<210>  10
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- IRAK4 1R

<400>  10
aaacgcgagt cttttgctcc caggc                                             25


<210>  11
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO IRAK4 2F

<400>  11
caccgctcat gtgccaagaa agtgg                                             25


<210>  12
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- IRAK4 2R

<400>  12
aaacccactt tcttggcaca tgagc                                             25


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- TMEM131 1F

<400>  13
caccgcttcc atacttagct caccc                                             25


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- TMEM131 1R

<400>  14
aaacgggtga gctaagtatg gaagc                                             25


<210>  15
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- TMEM131 2F

<400>  15
caccggaata tgggagccat ttcga                                             25


<210>  16
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- TMEM131 2R

<400>  16
aaactcgaaa tggctcccat attcc                                             25


<210>  17
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- EPC2 1F

<400>  17
caccggatgt ataggatttg caagg                                             25


<210>  18
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- EPC2 1R

<400>  18
aaacccttgc aaatcctata catcc                                             25


<210>  19
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- EPC2 2F

<400>  19
caccgtatta caatcgcttg tacaa                                             25


<210>  20
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- EPC2 2R

<400>  20
aaacttgtac aagcgattgt aatac                                             25


<210>  21
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- MBNL1 1F

<400>  21
caccggtatg tagagagttc cagag                                             25


<210>  22
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- MBNL1 1R

<400>  22
aaacctctgg aactctctac atacc                                             25


<210>  23
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- MBNL1 2F

<400>  23
caccggtatg tcgagagtac caacg                                             25


<210>  24
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- MBNL1 2R

<400>  24
aaaccgttgg tactctcgac atacc                                             25


<210>  25
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- ZNF813 1F

<400>  25
caccgagaca tgaaagtcat cacac                                             25


<210>  26
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- ZNF813 1R

<400>  26
aaacgtgtga tgactttcat gtctc                                             25


<210>  27
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- ZBTB20 1F

<400>  27
caccgcagcg acatcgagat cccgt                                             25


<210>  28
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- guide for single gene CRISPR KO- ZBTB20 1R

<400>  28
aaacacggga tctcgatgtc gctgc                                             25


<210>  29
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- primers for quantitative RT-PCR- SSR3 F

<400>  29
ggatttcagc cgcaatctct c                                                 21


<210>  30
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- primers for quantitative RT-PCR- SSR3 R

<400>  30
tgccatattc gccagtataa cc                                                22


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- primers for quantitative RT-PCR- IRAK4 F

<400>  31
cctgactcct caagtccaga a                                                 21


<210>  32
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- primers for quantitative RT-PCR- IRAK4 R

<400>  32
acagaaatgg gtcgttcatc aaa                                               23


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- primers for quantitative RT-PCR- TMEM131 F

<400>  33
gtgatgaccc tcgtagtggc                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- primers for quantitative RT-PCR- TMEM131 R

<400>  34
cggtctgtag tagccctcca                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- primers for quantitative RT-PCR- EPC2 F

<400>  35
caagccgctg cctatctacc                                                   20


<210>  36
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- primers for quantitative RT-PCR- EPC2 R

<400>  36
aaatgatgtt ccgattcctc ctc                                               23


<210>  37
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- primers for quantitative RT-PCR- MBNL1 F

<400>  37
gctgttagtg tcacaccaat tcg                                               23


<210>  38
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- primers for quantitative RT-PCR- MBNL1 R

<400>  38
aggcgattac tcgtccattt tc                                                22


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- primers for quantitative RT-PCR- ZNF813 F

<400>  39
acactggaga ctttcgcttt c                                                 21


<210>  40
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- primers for quantitative RT-PCR- ZNF813 R

<400>  40
gtttcgcttc cgattaaaga cct                                               23


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- primers for quantitative RT-PCR- ZBTB20 F

<400>  41
gacaggatct actcggcact c                                                 21


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- primers for quantitative RT-PCR- ZBTB20 R

<400>  42
actgcgccgc tgtaaaaaga                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- primers for quantitative RT-PCR- CEP63 F

<400>  43
tgggaaggac gtacacatgc                                                   20


<210>  44
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- primers for quantitative RT-PCR- CEP63 R

<400>  44
acatccaact gactcctaag act                                               23


<210>  45
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- primers for quantitative RT-PCR- RPS28 F

<400>  45
cgatccatca tccgcaatg                                                    19


<210>  46
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- primers for quantitative RT-PCR- RPS28 R

<400>  46
agccaagctc agcgcaac                                                     18


<210>  47
<211>  198
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(198)
<223>  SSR3 isoform 1

<400>  47

Met Ala Pro Lys Gly Ser Ser Lys Gln Gln Ser Glu Glu Asp Leu Leu 
1               5                   10                  15      


Leu Gln Asp Phe Ser Arg Asn Leu Ser Ala Lys Ser Ser Ala Leu Phe 
            20                  25                  30          


Phe Gly Asn Ala Phe Ile Val Ser Ala Ile Pro Ile Trp Leu Tyr Trp 
        35                  40                  45              


Arg Ile Trp His Met Asp Leu Ile Gln Ser Ala Val Leu Tyr Ser Val 
    50                  55                  60                  


Met Thr Leu Val Ser Thr Tyr Leu Val Ala Phe Ala Tyr Lys Asn Val 
65                  70                  75                  80  


Lys Phe Val Leu Lys His Lys Val Ala Gln Lys Arg Glu Asp Ala Val 
                85                  90                  95      


Ser Lys Glu Val Thr Arg Lys Leu Ser Glu Ala Asp Asn Arg Lys Met 
            100                 105                 110         


Ser Arg Lys Glu Lys Asp Glu Arg Phe Asp Ser Cys Leu Lys Tyr Gly 
        115                 120                 125             


His His Lys Arg Gly Ile Leu Trp Lys Lys Asn Glu Val Ala Asp Tyr 
    130                 135                 140                 


Glu Ala Thr Thr Phe Ser Ile Phe Tyr Asn Asn Thr Leu Phe Leu Val 
145                 150                 155                 160 


Val Val Ile Val Ala Ser Phe Phe Ile Leu Lys Asn Phe Asn Pro Thr 
                165                 170                 175     


Val Asn Tyr Ile Leu Ser Ile Ser Ala Ser Ser Gly Leu Ile Ala Leu 
            180                 185                 190         


Leu Ser Thr Gly Ser Lys 
        195             


<210>  48
<211>  343
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(343)
<223>  MBNL1 isoform 8

<400>  48

Met Gly Arg Cys Ser Arg Glu Asn Cys Lys Tyr Leu His Pro Pro Pro 
1               5                   10                  15      


His Leu Lys Thr Gln Leu Glu Ile Asn Gly Arg Asn Asn Leu Ile Gln 
            20                  25                  30          


Gln Lys Asn Met Ala Met Leu Ala Gln Gln Met Gln Leu Ala Asn Ala 
        35                  40                  45              


Met Met Pro Gly Ala Pro Leu Gln Pro Val Pro Met Phe Ser Val Ala 
    50                  55                  60                  


Pro Ser Leu Ala Thr Asn Ala Ser Ala Ala Ala Phe Asn Pro Tyr Leu 
65                  70                  75                  80  


Gly Pro Val Ser Pro Ser Leu Val Pro Ala Glu Ile Leu Pro Thr Ala 
                85                  90                  95      


Pro Met Leu Val Thr Gly Asn Pro Gly Val Pro Val Pro Ala Ala Ala 
            100                 105                 110         


Ala Ala Ala Ala Gln Lys Leu Met Arg Thr Asp Arg Leu Glu Val Cys 
        115                 120                 125             


Arg Glu Tyr Gln Arg Gly Asn Cys Asn Arg Gly Glu Asn Asp Cys Arg 
    130                 135                 140                 


Phe Ala His Pro Ala Asp Ser Thr Met Ile Asp Thr Asn Asp Asn Thr 
145                 150                 155                 160 


Val Thr Val Cys Met Asp Tyr Ile Lys Gly Arg Cys Ser Arg Glu Lys 
                165                 170                 175     


Cys Lys Tyr Phe His Pro Pro Ala His Leu Gln Ala Lys Ile Lys Ala 
            180                 185                 190         


Ala Gln Tyr Gln Val Asn Gln Ala Ala Ala Ala Gln Ala Ala Ala Thr 
        195                 200                 205             


Ala Ala Ala Met Thr Gln Ser Ala Val Lys Ser Leu Lys Arg Pro Leu 
    210                 215                 220                 


Glu Ala Thr Phe Asp Leu Gly Ile Pro Gln Ala Val Leu Pro Pro Leu 
225                 230                 235                 240 


Pro Lys Arg Pro Ala Leu Glu Lys Thr Asn Gly Ala Thr Ala Val Phe 
                245                 250                 255     


Asn Thr Gly Ile Phe Gln Tyr Gln Gln Ala Leu Ala Asn Met Gln Leu 
            260                 265                 270         


Gln Gln His Thr Ala Phe Leu Pro Pro Gly Ser Ile Leu Cys Met Thr 
        275                 280                 285             


Pro Ala Thr Ser Val Val Pro Met Val His Gly Ala Thr Pro Ala Thr 
    290                 295                 300                 


Val Ser Ala Ala Thr Thr Ser Ala Thr Ser Val Pro Phe Ala Ala Thr 
305                 310                 315                 320 


Ala Thr Ala Asn Gln Ile Pro Ile Ile Ser Ala Glu His Leu Thr Ser 
                325                 330                 335     


His Lys Tyr Val Thr Gln Met 
            340             


<210>  49
<211>  1176
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1176)
<223>  TDRD1 isoform 2

<400>  49

Met Ser Val Lys Ser Pro Phe Asn Val Met Ser Arg Asn Asn Leu Glu 
1               5                   10                  15      


Ala Pro Pro Cys Lys Met Thr Glu Pro Phe Asn Phe Glu Lys Asn Glu 
            20                  25                  30          


Asn Lys Leu Pro Pro His Glu Ser Leu Arg Ser Pro Gly Thr Leu Pro 
        35                  40                  45              


Asn His Pro Asn Phe Arg Leu Lys Ser Ser Glu Asn Gly Asn Lys Lys 
    50                  55                  60                  


Asn Asn Phe Leu Leu Cys Glu Gln Thr Lys Gln Tyr Leu Ala Ser Gln 
65                  70                  75                  80  


Glu Asp Asn Ser Val Ser Ser Asn Pro Asn Gly Ile Asn Gly Glu Val 
                85                  90                  95      


Val Gly Ser Lys Gly Asp Arg Lys Lys Leu Pro Ala Gly Asn Ser Val 
            100                 105                 110         


Ser Pro Pro Ser Ala Glu Ser Asn Ser Pro Pro Lys Glu Val Asn Ile 
        115                 120                 125             


Lys Pro Gly Asn Asn Val Arg Pro Ala Lys Ser Lys Lys Leu Asn Lys 
    130                 135                 140                 


Leu Val Glu Asn Ser Leu Ser Ile Ser Asn Pro Gly Leu Phe Thr Ser 
145                 150                 155                 160 


Leu Gly Pro Pro Leu Arg Ser Thr Thr Cys His Arg Cys Gly Leu Phe 
                165                 170                 175     


Gly Ser Leu Arg Cys Ser Gln Cys Lys Gln Thr Tyr Tyr Cys Ser Thr 
            180                 185                 190         


Ala Cys Gln Arg Arg Asp Trp Ser Ala His Ser Ile Val Cys Arg Pro 
        195                 200                 205             


Val Gln Pro Asn Phe His Lys Leu Glu Asn Lys Ser Ser Ile Glu Thr 
    210                 215                 220                 


Lys Asp Val Glu Val Asn Asn Lys Ser Asp Cys Pro Leu Gly Val Thr 
225                 230                 235                 240 


Lys Glu Ile Ala Ile Trp Ala Glu Arg Ile Met Phe Ser Asp Leu Arg 
                245                 250                 255     


Ser Leu Gln Leu Lys Lys Thr Met Glu Ile Lys Gly Thr Val Thr Glu 
            260                 265                 270         


Phe Lys His Pro Gly Asp Phe Tyr Val Gln Leu Tyr Ser Ser Glu Val 
        275                 280                 285             


Leu Glu Tyr Met Asn Gln Leu Ser Ala Ser Leu Lys Glu Thr Tyr Ala 
    290                 295                 300                 


Asn Val His Glu Lys Asp Tyr Ile Pro Val Lys Gly Glu Val Cys Ile 
305                 310                 315                 320 


Ala Lys Tyr Thr Val Asp Gln Thr Trp Asn Arg Ala Ile Ile Gln Asn 
                325                 330                 335     


Val Asp Val Gln Gln Lys Lys Ala His Val Leu Tyr Ile Asp Tyr Gly 
            340                 345                 350         


Asn Glu Glu Ile Ile Pro Leu Asn Arg Ile Tyr His Leu Asn Arg Asn 
        355                 360                 365             


Ile Asp Leu Phe Pro Pro Cys Ala Ile Lys Cys Phe Val Ala Asn Val 
    370                 375                 380                 


Ile Pro Ala Glu Gly Asn Trp Ser Ser Asp Cys Ile Lys Ala Thr Lys 
385                 390                 395                 400 


Pro Leu Leu Met Glu Gln Tyr Cys Ser Ile Lys Ile Val Asp Ile Leu 
                405                 410                 415     


Glu Glu Glu Val Val Thr Phe Ala Val Glu Val Glu Leu Pro Asn Ser 
            420                 425                 430         


Gly Lys Leu Leu Asp His Val Leu Ile Glu Met Gly Tyr Gly Leu Lys 
        435                 440                 445             


Pro Ser Gly Gln Asp Ser Lys Lys Glu Asn Ala Asp Gln Ser Asp Pro 
    450                 455                 460                 


Glu Asp Val Gly Lys Met Thr Thr Glu Asn Asn Ile Val Val Asp Lys 
465                 470                 475                 480 


Ser Asp Leu Ile Pro Lys Val Leu Thr Leu Asn Val Gly Asp Glu Phe 
                485                 490                 495     


Cys Gly Val Val Ala His Ile Gln Thr Pro Glu Asp Phe Phe Cys Gln 
            500                 505                 510         


Gln Leu Gln Ser Gly Arg Lys Leu Ala Glu Leu Gln Ala Ser Leu Ser 
        515                 520                 525             


Lys Tyr Cys Asp Gln Leu Pro Pro Arg Ser Asp Phe Tyr Pro Ala Ile 
    530                 535                 540                 


Gly Asp Ile Cys Cys Ala Gln Phe Ser Glu Asp Asp Gln Trp Tyr Arg 
545                 550                 555                 560 


Ala Ser Val Leu Ala Tyr Ala Ser Glu Glu Ser Val Leu Val Gly Tyr 
                565                 570                 575     


Val Asp Tyr Gly Asn Phe Glu Ile Leu Ser Leu Met Arg Leu Cys Pro 
            580                 585                 590         


Ile Ile Pro Lys Leu Leu Glu Leu Pro Met Gln Ala Ile Lys Cys Val 
        595                 600                 605             


Leu Ala Gly Val Lys Pro Ser Leu Gly Ile Trp Thr Pro Glu Ala Ile 
    610                 615                 620                 


Cys Leu Met Lys Lys Leu Val Gln Asn Lys Ile Ile Thr Val Lys Val 
625                 630                 635                 640 


Val Asp Lys Leu Glu Asn Ser Ser Leu Val Glu Leu Ile Asp Lys Ser 
                645                 650                 655     


Glu Thr Pro His Val Ser Val Ser Lys Val Leu Leu Asp Ala Gly Phe 
            660                 665                 670         


Ala Val Gly Glu Gln Ser Met Val Thr Asp Lys Pro Ser Asp Val Lys 
        675                 680                 685             


Glu Thr Ser Val Pro Leu Gly Val Glu Gly Lys Val Asn Pro Leu Glu 
    690                 695                 700                 


Trp Thr Trp Val Glu Leu Gly Val Asp Gln Thr Val Asp Val Val Val 
705                 710                 715                 720 


Cys Val Ile Tyr Ser Pro Gly Glu Phe Tyr Cys His Val Leu Lys Glu 
                725                 730                 735     


Asp Ala Leu Lys Lys Leu Asn Asp Leu Asn Lys Ser Leu Ala Glu His 
            740                 745                 750         


Cys Gln Gln Lys Leu Pro Asn Gly Phe Lys Ala Glu Ile Gly Gln Pro 
        755                 760                 765             


Cys Cys Ala Phe Phe Ala Gly Asp Gly Ser Trp Tyr Arg Ala Leu Val 
    770                 775                 780                 


Lys Glu Ile Leu Pro Asn Gly His Val Lys Val His Phe Val Asp Tyr 
785                 790                 795                 800 


Gly Asn Ile Glu Glu Val Thr Ala Asp Glu Leu Arg Met Ile Ser Ser 
                805                 810                 815     


Thr Phe Leu Asn Leu Pro Phe Gln Gly Ile Arg Cys Gln Leu Ala Asp 
            820                 825                 830         


Ile Gln Ser Arg Asn Lys His Trp Ser Glu Glu Ala Ile Thr Arg Phe 
        835                 840                 845             


Gln Met Cys Val Ala Gly Ile Lys Leu Gln Ala Arg Val Val Glu Val 
    850                 855                 860                 


Thr Glu Asn Gly Ile Gly Val Glu Leu Thr Asp Leu Ser Thr Cys Tyr 
865                 870                 875                 880 


Pro Arg Ile Ile Ser Asp Val Leu Ile Asp Glu His Leu Val Leu Lys 
                885                 890                 895     


Ser Ala Ser Pro His Lys Asp Leu Pro Asn Asp Arg Leu Val Asn Lys 
            900                 905                 910         


His Glu Leu Gln Val His Val Gln Gly Leu Gln Ala Glu Gln Trp Lys 
        915                 920                 925             


Thr Ile Glu Leu Pro Val Asp Lys Thr Ile Gln Ala Asn Val Leu Glu 
    930                 935                 940                 


Ile Ile Ser Pro Asn Leu Phe Tyr Ala Leu Pro Lys Gly Met Pro Glu 
945                 950                 955                 960 


Asn Gln Glu Lys Leu Cys Met Leu Thr Ala Glu Leu Leu Glu Tyr Cys 
                965                 970                 975     


Asn Ala Pro Lys Ser Arg Pro Pro Tyr Arg Pro Arg Ile Gly Asp Ala 
            980                 985                 990         


Cys Cys Ala Lys Tyr Thr Ser Asp  Asp Phe Trp Tyr Arg  Ala Val Val 
        995                 1000                 1005             


Leu Gly  Thr Ser Asp Thr Asp  Val Glu Val Leu Tyr  Ala Asp Tyr 
    1010                 1015                 1020             


Gly Asn  Ile Glu Thr Leu Pro  Leu Cys Arg Val Gln  Pro Ile Thr 
    1025                 1030                 1035             


Ser Ser  His Leu Ala Leu Pro  Phe Gln Ile Ile Arg  Cys Ser Leu 
    1040                 1045                 1050             


Glu Gly  Leu Met Glu Leu Asn  Gly Ser Ser Ser Gln  Leu Ile Ile 
    1055                 1060                 1065             


Met Leu  Leu Lys Asn Phe Met  Leu Asn Gln Asn Val  Met Leu Ser 
    1070                 1075                 1080             


Val Lys  Gly Ile Thr Lys Asn  Val His Thr Val Ser  Val Glu Lys 
    1085                 1090                 1095             


Cys Ser  Glu Asn Gly Thr Val  Asp Val Ala Asp Lys  Leu Val Thr 
    1100                 1105                 1110             


Phe Gly  Leu Ala Lys Asn Ile  Thr Pro Gln Arg Gln  Ser Ala Leu 
    1115                 1120                 1125             


Asn Thr  Glu Lys Met Tyr Arg  Met Asn Cys Cys Cys  Thr Glu Leu 
    1130                 1135                 1140             


Gln Lys  Gln Val Glu Lys His  Glu His Ile Leu Leu  Phe Leu Leu 
    1145                 1150                 1155             


Asn Asn  Ser Thr Asn Gln Asn  Lys Phe Ile Glu Met  Lys Lys Leu 
    1160                 1165                 1170             


Leu Lys  Ser 
    1175     


<210>  50
<211>  495
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(495)
<223>  CEP63 isoform c

<400>  50

Met Glu Ala Leu Leu Glu Gly Ile Gln Asn Arg Gly His Gly Gly Gly 
1               5                   10                  15      


Phe Leu Thr Ser Cys Glu Ala Glu Leu Gln Glu Leu Met Lys Gln Ile 
            20                  25                  30          


Asp Ile Met Val Ala His Lys Lys Ser Glu Trp Glu Gly Arg Thr His 
        35                  40                  45              


Ala Leu Glu Thr Cys Leu Lys Ile Arg Glu Gln Glu Leu Lys Ser Leu 
    50                  55                  60                  


Arg Ser Gln Leu Asp Val Thr His Lys Glu Val Gly Met Leu His Gln 
65                  70                  75                  80  


Gln Val Glu Glu His Glu Lys Ile Lys Gln Glu Met Thr Met Glu Tyr 
                85                  90                  95      


Lys Gln Glu Leu Lys Lys Leu His Glu Glu Leu Cys Ile Leu Lys Arg 
            100                 105                 110         


Ser Tyr Glu Lys Leu Gln Lys Lys Gln Met Arg Glu Phe Arg Gly Asn 
        115                 120                 125             


Thr Lys Asn His Arg Glu Asp Arg Ser Glu Ile Glu Arg Leu Thr Ala 
    130                 135                 140                 


Lys Ile Glu Glu Phe Arg Gln Lys Ser Leu Asp Trp Glu Lys Gln Arg 
145                 150                 155                 160 


Leu Ile Tyr Gln Gln Gln Val Ser Ser Leu Glu Ala Gln Arg Lys Ala 
                165                 170                 175     


Leu Ala Glu Gln Ser Glu Ile Ile Gln Ala Gln Leu Val Asn Arg Lys 
            180                 185                 190         


Gln Lys Leu Glu Ser Val Glu Leu Ser Ser Gln Ser Glu Ile Gln His 
        195                 200                 205             


Leu Ser Ser Lys Leu Glu Arg Ala Asn Asp Thr Ile Cys Ala Asn Glu 
    210                 215                 220                 


Leu Glu Ile Glu Arg Leu Thr Met Arg Val Asn Asp Leu Val Gly Thr 
225                 230                 235                 240 


Ser Met Thr Val Leu Gln Glu Gln Gln Gln Lys Glu Glu Lys Leu Arg 
                245                 250                 255     


Glu Ser Glu Lys Leu Leu Glu Ala Leu Gln Glu Glu Lys Arg Glu Leu 
            260                 265                 270         


Lys Ala Ala Leu Gln Ser Gln Glu Asn Leu Ile His Glu Ala Arg Ile 
        275                 280                 285             


Gln Lys Glu Lys Leu Gln Glu Lys Val Lys Ala Thr Asn Thr Gln His 
    290                 295                 300                 


Ala Val Glu Ala Ile Ser Leu Glu Ser Val Ser Ala Thr Cys Lys Gln 
305                 310                 315                 320 


Leu Ser Gln Glu Leu Met Glu Lys Tyr Glu Glu Leu Lys Arg Met Glu 
                325                 330                 335     


Ala His Asn Asn Glu Tyr Lys Ala Glu Ile Lys Lys Leu Lys Glu Gln 
            340                 345                 350         


Ile Leu Gln Gly Glu Gln Ser Tyr Ser Ser Ala Leu Glu Gly Met Lys 
        355                 360                 365             


Met Glu Ile Ser His Leu Thr Gln Glu Leu His Gln Arg Asp Ile Thr 
    370                 375                 380                 


Ile Ala Ser Thr Lys Gly Ser Ser Ser Asp Met Glu Lys Arg Leu Arg 
385                 390                 395                 400 


Ala Glu Met Gln Lys Ala Glu Asp Lys Ala Val Glu His Lys Glu Ile 
                405                 410                 415     


Leu Asp Gln Leu Glu Ser Leu Lys Leu Glu Asn Arg His Leu Ser Glu 
            420                 425                 430         


Met Val Met Lys Leu Glu Leu Gly Leu His Glu Cys Ser Leu Pro Val 
        435                 440                 445             


Ser Pro Leu Gly Ser Ile Ala Thr Arg Phe Leu Glu Glu Glu Glu Leu 
    450                 455                 460                 


Arg Ser His His Ile Leu Glu Arg Leu Asp Ala His Ile Glu Glu Leu 
465                 470                 475                 480 


Lys Arg Glu Ser Glu Lys Thr Val Arg Gln Phe Thr Ala Leu Lys 
                485                 490                 495 


<210>  51
<211>  455
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(455)
<223>  IRAK4 isoform a

<400>  51

Met Asn Lys Pro Ile Thr Pro Ser Thr Tyr Val Arg Cys Leu Asn Val 
1               5                   10                  15      


Gly Leu Ile Arg Lys Leu Ser Asp Phe Ile Asp Pro Gln Glu Gly Trp 
            20                  25                  30          


Lys Lys Leu Ala Val Ala Ile Lys Lys Pro Ser Gly Asp Asp Arg Tyr 
        35                  40                  45              


Asn Gln Phe His Ile Arg Arg Phe Glu Ala Leu Leu Gln Thr Gly Lys 
    50                  55                  60                  


Ser Pro Thr Ser Glu Leu Leu Phe Asp Trp Gly Thr Thr Asn Cys Thr 
65                  70                  75                  80  


Val Gly Asp Leu Val Asp Leu Leu Ile Gln Asn Glu Phe Phe Ala Pro 
                85                  90                  95      


Ala Ser Leu Leu Leu Pro Asp Ala Val Pro Lys Thr Ala Asn Thr Leu 
            100                 105                 110         


Pro Ser Lys Glu Ala Ile Thr Val Gln Gln Lys Gln Met Pro Phe Cys 
        115                 120                 125             


Asp Lys Asp Arg Thr Leu Met Thr Pro Val Gln Asn Leu Glu Gln Ser 
    130                 135                 140                 


Tyr Met Pro Pro Asp Ser Ser Ser Pro Glu Asn Lys Ser Leu Glu Val 
145                 150                 155                 160 


Ser Asp Thr Arg Phe His Ser Phe Ser Phe Tyr Glu Leu Lys Asn Val 
                165                 170                 175     


Thr Asn Asn Phe Asp Glu Arg Pro Ile Ser Val Gly Gly Asn Lys Met 
            180                 185                 190         


Gly Glu Gly Gly Phe Gly Val Val Tyr Lys Gly Tyr Val Asn Asn Thr 
        195                 200                 205             


Thr Val Ala Val Lys Lys Leu Ala Ala Met Val Asp Ile Thr Thr Glu 
    210                 215                 220                 


Glu Leu Lys Gln Gln Phe Asp Gln Glu Ile Lys Val Met Ala Lys Cys 
225                 230                 235                 240 


Gln His Glu Asn Leu Val Glu Leu Leu Gly Phe Ser Ser Asp Gly Asp 
                245                 250                 255     


Asp Leu Cys Leu Val Tyr Val Tyr Met Pro Asn Gly Ser Leu Leu Asp 
            260                 265                 270         


Arg Leu Ser Cys Leu Asp Gly Thr Pro Pro Leu Ser Trp His Met Arg 
        275                 280                 285             


Cys Lys Ile Ala Gln Gly Ala Ala Asn Gly Ile Asn Phe Leu His Glu 
    290                 295                 300                 


Asn His His Ile His Arg Asp Ile Lys Ser Ala Asn Ile Leu Leu Asp 
305                 310                 315                 320 


Glu Ala Phe Thr Ala Lys Ile Ser Asp Phe Gly Leu Ala Arg Ala Ser 
                325                 330                 335     


Glu Lys Phe Ala Gln Thr Val Met Thr Ser Arg Ile Val Gly Thr Thr 
            340                 345                 350         


Ala Tyr Met Ala Pro Glu Ala Leu Arg Gly Glu Ile Thr Pro Lys Ser 
        355                 360                 365             


Asp Ile Tyr Ser Phe Gly Val Val Leu Leu Glu Ile Ile Thr Gly Leu 
    370                 375                 380                 


Pro Ala Val Asp Glu His Arg Glu Pro Gln Leu Leu Leu Asp Ile Lys 
385                 390                 395                 400 


Glu Glu Ile Glu Asp Glu Glu Lys Thr Ile Glu Asp Tyr Ile Asp Lys 
                405                 410                 415     


Lys Met Asn Asp Ala Asp Ser Thr Ser Val Glu Ala Met Tyr Ser Val 
            420                 425                 430         


Ala Ser Gln Cys Leu His Glu Lys Lys Asn Lys Arg Pro Asp Ile Lys 
        435                 440                 445             


Lys Val Gln Gln Leu Leu Gln 
    450                 455 


<210>  52
<211>  1883
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1883)
<223>  TMEM131

<400>  52

Met Gly Lys Arg Ala Gly Gly Gly Ala Thr Gly Ala Thr Thr Ala Ala 
1               5                   10                  15      


Val Ser Thr Ser Ala Gly Ala Gly Leu Glu Pro Ala Ala Ala Arg Ser 
            20                  25                  30          


Gly Gly Pro Arg Ser Ala Ala Ala Gly Leu Leu Gly Ala Leu His Leu 
        35                  40                  45              


Val Met Thr Leu Val Val Ala Ala Ala Arg Ala Glu Lys Glu Ala Phe 
    50                  55                  60                  


Val Gln Ser Glu Ser Ile Ile Glu Val Leu Arg Phe Asp Asp Gly Gly 
65                  70                  75                  80  


Leu Leu Gln Thr Glu Thr Thr Leu Gly Leu Ser Ser Tyr Gln Gln Lys 
                85                  90                  95      


Ser Ile Ser Leu Tyr Arg Gly Asn Cys Arg Pro Ile Arg Phe Glu Pro 
            100                 105                 110         


Pro Met Leu Asp Phe His Glu Gln Pro Val Gly Met Pro Lys Met Glu 
        115                 120                 125             


Lys Val Tyr Leu His Asn Pro Ser Ser Glu Glu Thr Ile Thr Leu Val 
    130                 135                 140                 


Ser Ile Ser Ala Thr Thr Ser His Phe His Ala Ser Phe Phe Gln Asn 
145                 150                 155                 160 


Arg Lys Ile Leu Pro Gly Gly Asn Thr Ser Phe Asp Val Val Phe Leu 
                165                 170                 175     


Ala Arg Val Val Gly Asn Val Glu Asn Thr Leu Phe Ile Asn Thr Ser 
            180                 185                 190         


Asn His Gly Val Phe Thr Tyr Gln Val Phe Gly Val Gly Val Pro Asn 
        195                 200                 205             


Pro Tyr Arg Leu Arg Pro Phe Leu Gly Ala Arg Val Pro Val Asn Ser 
    210                 215                 220                 


Ser Phe Ser Pro Ile Ile Asn Ile His Asn Pro His Ser Glu Pro Leu 
225                 230                 235                 240 


Gln Val Val Glu Met Tyr Ser Ser Gly Gly Asp Leu His Leu Glu Leu 
                245                 250                 255     


Pro Thr Gly Gln Gln Gly Gly Thr Arg Lys Leu Trp Glu Ile Pro Pro 
            260                 265                 270         


Tyr Glu Thr Lys Gly Val Met Arg Ala Ser Phe Ser Ser Arg Glu Ala 
        275                 280                 285             


Asp Asn His Thr Ala Phe Ile Arg Ile Lys Thr Asn Ala Ser Asp Ser 
    290                 295                 300                 


Thr Glu Phe Ile Ile Leu Pro Val Glu Val Glu Val Thr Thr Ala Pro 
305                 310                 315                 320 


Gly Ile Tyr Ser Ser Thr Glu Met Leu Asp Phe Gly Thr Leu Arg Thr 
                325                 330                 335     


Gln Asp Leu Pro Lys Val Leu Asn Leu His Leu Leu Asn Ser Gly Thr 
            340                 345                 350         


Lys Asp Val Pro Ile Thr Ser Val Arg Pro Thr Pro Gln Asn Asp Ala 
        355                 360                 365             


Ile Thr Val His Phe Lys Pro Ile Thr Leu Lys Ala Ser Glu Ser Lys 
    370                 375                 380                 


Tyr Thr Lys Val Ala Ser Ile Ser Phe Asp Ala Ser Lys Ala Lys Lys 
385                 390                 395                 400 


Pro Ser Gln Phe Ser Gly Lys Ile Thr Val Lys Ala Lys Glu Lys Ser 
                405                 410                 415     


Tyr Ser Lys Leu Glu Ile Pro Tyr Gln Ala Glu Val Leu Asp Gly Tyr 
            420                 425                 430         


Leu Gly Phe Asp His Ala Ala Thr Leu Phe His Ile Arg Asp Ser Pro 
        435                 440                 445             


Ala Asp Pro Val Glu Arg Pro Ile Tyr Leu Thr Asn Thr Phe Ser Phe 
    450                 455                 460                 


Ala Ile Leu Ile His Asp Val Leu Leu Pro Glu Glu Ala Lys Thr Met 
465                 470                 475                 480 


Phe Lys Val His Asn Phe Ser Lys Pro Val Leu Ile Leu Pro Asn Glu 
                485                 490                 495     


Ser Gly Tyr Ile Phe Thr Leu Leu Phe Met Pro Ser Thr Ser Ser Met 
            500                 505                 510         


His Ile Asp Asn Asn Ile Leu Leu Ile Thr Asn Ala Ser Lys Phe His 
        515                 520                 525             


Leu Pro Val Arg Val Tyr Thr Gly Phe Leu Asp Tyr Phe Val Leu Pro 
    530                 535                 540                 


Pro Lys Ile Glu Glu Arg Phe Ile Asp Phe Gly Val Leu Ser Ala Thr 
545                 550                 555                 560 


Glu Ala Ser Asn Ile Leu Phe Ala Ile Ile Asn Ser Asn Pro Ile Glu 
                565                 570                 575     


Leu Ala Ile Lys Ser Trp His Ile Ile Gly Asp Gly Leu Ser Ile Glu 
            580                 585                 590         


Leu Val Ala Val Glu Arg Gly Asn Arg Thr Thr Ile Ile Ser Ser Leu 
        595                 600                 605             


Pro Glu Phe Glu Lys Ser Ser Leu Ser Asp Gln Ser Ser Val Thr Leu 
    610                 615                 620                 


Ala Ser Gly Tyr Phe Ala Val Phe Arg Val Lys Leu Thr Ala Lys Lys 
625                 630                 635                 640 


Leu Glu Gly Ile His Asp Gly Ala Ile Gln Ile Thr Thr Asp Tyr Glu 
                645                 650                 655     


Ile Leu Thr Ile Pro Val Lys Ala Val Ile Ala Val Gly Ser Leu Thr 
            660                 665                 670         


Cys Phe Pro Lys His Val Val Leu Pro Pro Ser Phe Pro Gly Lys Ile 
        675                 680                 685             


Val His Gln Ser Leu Asn Ile Met Asn Ser Phe Ser Gln Lys Val Lys 
    690                 695                 700                 


Ile Gln Gln Ile Arg Ser Leu Ser Glu Asp Val Arg Phe Tyr Tyr Lys 
705                 710                 715                 720 


Arg Leu Arg Gly Asn Lys Glu Asp Leu Glu Pro Gly Lys Lys Ser Lys 
                725                 730                 735     


Ile Ala Asn Ile Tyr Phe Asp Pro Gly Leu Gln Cys Gly Asp His Cys 
            740                 745                 750         


Tyr Val Gly Leu Pro Phe Leu Ser Lys Ser Glu Pro Lys Val Gln Pro 
        755                 760                 765             


Gly Val Ala Met Gln Glu Asp Met Trp Asp Ala Asp Trp Asp Leu His 
    770                 775                 780                 


Gln Ser Leu Phe Lys Gly Trp Thr Gly Ile Lys Glu Asn Ser Gly His 
785                 790                 795                 800 


Arg Leu Ser Ala Ile Phe Glu Val Asn Thr Asp Leu Gln Lys Asn Ile 
                805                 810                 815     


Ile Ser Lys Ile Thr Ala Glu Leu Ser Trp Pro Ser Ile Leu Ser Ser 
            820                 825                 830         


Pro Arg His Leu Lys Phe Pro Leu Thr Asn Thr Asn Cys Ser Ser Glu 
        835                 840                 845             


Glu Glu Ile Thr Leu Glu Asn Pro Ala Asp Val Pro Val Tyr Val Gln 
    850                 855                 860                 


Phe Ile Pro Leu Ala Leu Tyr Ser Asn Pro Ser Val Phe Val Asp Lys 
865                 870                 875                 880 


Leu Val Ser Arg Phe Asn Leu Ser Lys Val Ala Lys Ile Asp Leu Arg 
                885                 890                 895     


Thr Leu Glu Phe Gln Val Phe Arg Asn Ser Ala His Pro Leu Gln Ser 
            900                 905                 910         


Ser Thr Gly Phe Met Glu Gly Leu Ser Arg His Leu Ile Leu Asn Leu 
        915                 920                 925             


Ile Leu Lys Pro Gly Glu Lys Lys Ser Val Lys Val Lys Phe Thr Pro 
    930                 935                 940                 


Val His Asn Arg Thr Val Ser Ser Leu Ile Ile Val Arg Asn Asn Leu 
945                 950                 955                 960 


Thr Val Met Asp Ala Val Met Val Gln Gly Gln Gly Thr Thr Glu Asn 
                965                 970                 975     


Leu Arg Val Ala Gly Lys Leu Pro Gly Pro Gly Ser Ser Leu Arg Phe 
            980                 985                 990         


Lys Ile Thr Glu Ala Leu Leu Lys  Asp Cys Thr Asp Ser  Leu Lys Leu 
        995                 1000                 1005             


Arg Glu  Pro Asn Phe Thr Leu  Lys Arg Thr Phe Lys  Val Glu Asn 
    1010                 1015                 1020             


Thr Gly  Gln Leu Gln Ile His  Ile Glu Thr Ile Glu  Ile Ser Gly 
    1025                 1030                 1035             


Tyr Ser  Cys Glu Gly Tyr Gly  Phe Lys Val Val Asn  Cys Gln Glu 
    1040                 1045                 1050             


Phe Thr  Leu Ser Ala Asn Ala  Ser Arg Asp Ile Ile  Ile Leu Phe 
    1055                 1060                 1065             


Thr Pro  Asp Phe Thr Ala Ser  Arg Val Ile Arg Glu  Leu Lys Phe 
    1070                 1075                 1080             


Ile Thr  Thr Ser Gly Ser Glu  Phe Val Phe Ile Leu  Asn Ala Ser 
    1085                 1090                 1095             


Leu Pro  Tyr His Met Leu Ala  Thr Cys Ala Glu Ala  Leu Pro Arg 
    1100                 1105                 1110             


Pro Asn  Trp Glu Leu Ala Leu  Tyr Ile Ile Ile Ser  Gly Ile Met 
    1115                 1120                 1125             


Ser Ala  Leu Phe Leu Leu Val  Ile Gly Thr Ala Tyr  Leu Glu Ala 
    1130                 1135                 1140             


Gln Gly  Ile Trp Glu Pro Phe  Arg Arg Arg Leu Ser  Phe Glu Ala 
    1145                 1150                 1155             


Ser Asn  Pro Pro Phe Asp Val  Gly Arg Pro Phe Asp  Leu Arg Arg 
    1160                 1165                 1170             


Ile Val  Gly Ile Ser Ser Glu  Gly Asn Leu Asn Thr  Leu Ser Cys 
    1175                 1180                 1185             


Asp Pro  Gly His Ser Arg Gly  Phe Cys Gly Ala Gly  Gly Ser Ser 
    1190                 1195                 1200             


Ser Arg  Pro Ser Ala Gly Ser  His Lys Gln Cys Gly  Pro Ser Val 
    1205                 1210                 1215             


His Pro  His Ser Ser His Ser  Asn Arg Asn Ser Ala  Asp Val Glu 
    1220                 1225                 1230             


Asn Val  Arg Ala Lys Asn Ser  Ser Ser Thr Ser Ser  Arg Thr Ser 
    1235                 1240                 1245             


Ala Gln  Ala Ala Ser Ser Gln  Ser Ala Asn Lys Thr  Ser Pro Leu 
    1250                 1255                 1260             


Val Leu  Asp Ser Asn Thr Val  Thr Gln Gly His Thr  Ala Gly Arg 
    1265                 1270                 1275             


Lys Ser  Lys Gly Ala Lys Gln  Ser Gln His Gly Ser  Gln His His 
    1280                 1285                 1290             


Ala His  Ser Pro Leu Glu Gln  His Pro Gln Pro Pro  Leu Pro Pro 
    1295                 1300                 1305             


Pro Val  Pro Gln Pro Gln Glu  Pro Gln Pro Glu Arg  Leu Ser Pro 
    1310                 1315                 1320             


Ala Pro  Leu Ala His Pro Ser  His Pro Glu Arg Ala  Ser Ser Ala 
    1325                 1330                 1335             


Arg His  Ser Ser Glu Asp Ser  Asp Ile Thr Ser Leu  Ile Glu Ala 
    1340                 1345                 1350             


Met Asp  Lys Asp Phe Asp His  His Asp Ser Pro Ala  Leu Glu Val 
    1355                 1360                 1365             


Phe Thr  Glu Gln Pro Pro Ser  Pro Leu Pro Lys Ser  Lys Gly Lys 
    1370                 1375                 1380             


Gly Lys  Pro Leu Gln Arg Lys  Val Lys Pro Pro Lys  Lys Gln Glu 
    1385                 1390                 1395             


Glu Lys  Glu Lys Lys Gly Lys  Gly Lys Pro Gln Glu  Asp Glu Leu 
    1400                 1405                 1410             


Lys Asp  Ser Leu Ala Asp Asp  Asp Ser Ser Ser Thr  Thr Thr Glu 
    1415                 1420                 1425             


Thr Ser  Asn Pro Asp Thr Glu  Pro Leu Leu Lys Glu  Asp Thr Glu 
    1430                 1435                 1440             


Lys Gln  Lys Gly Lys Gln Ala  Met Pro Glu Lys His  Glu Ser Glu 
    1445                 1450                 1455             


Met Ser  Gln Val Lys Gln Lys  Ser Lys Lys Leu Leu  Asn Ile Lys 
    1460                 1465                 1470             


Lys Glu  Ile Pro Thr Asp Val  Lys Pro Ser Ser Leu  Glu Leu Pro 
    1475                 1480                 1485             


Tyr Thr  Pro Pro Leu Glu Ser  Lys Gln Arg Arg Asn  Leu Pro Ser 
    1490                 1495                 1500             


Lys Ile  Pro Leu Pro Thr Ala  Met Thr Ser Gly Ser  Lys Ser Arg 
    1505                 1510                 1515             


Asn Ala  Gln Lys Thr Lys Gly  Thr Ser Lys Leu Val  Asp Asn Arg 
    1520                 1525                 1530             


Pro Pro  Ala Leu Ala Lys Phe  Leu Pro Asn Ser Gln  Glu Leu Gly 
    1535                 1540                 1545             


Asn Thr  Ser Ser Ser Glu Gly  Glu Lys Asp Ser Pro  Pro Pro Glu 
    1550                 1555                 1560             


Trp Asp  Ser Val Pro Val His  Lys Pro Gly Ser Ser  Thr Asp Ser 
    1565                 1570                 1575             


Leu Tyr  Lys Leu Ser Leu Gln  Thr Leu Asn Ala Asp  Ile Phe Leu 
    1580                 1585                 1590             


Lys Gln  Arg Gln Thr Ser Pro  Thr Pro Ala Ser Pro  Ser Pro Pro 
    1595                 1600                 1605             


Ala Ala  Pro Cys Pro Phe Val  Ala Arg Gly Ser Tyr  Ser Ser Ile 
    1610                 1615                 1620             


Val Asn  Ser Ser Ser Ser Ser  Asp Pro Lys Ile Lys  Gln Pro Asn 
    1625                 1630                 1635             


Gly Ser  Lys His Lys Leu Thr  Lys Ala Ala Ser Leu  Pro Gly Lys 
    1640                 1645                 1650             


Asn Gly  Asn Pro Thr Phe Ala  Ala Val Thr Ala Gly  Tyr Asp Lys 
    1655                 1660                 1665             


Ser Pro  Gly Gly Asn Gly Phe  Ala Lys Val Ser Ser  Asn Lys Thr 
    1670                 1675                 1680             


Gly Phe  Ser Ser Ser Leu Gly  Ile Ser His Ala Pro  Val Asp Ser 
    1685                 1690                 1695             


Asp Gly  Ser Asp Ser Ser Gly  Leu Trp Ser Pro Val  Ser Asn Pro 
    1700                 1705                 1710             


Ser Ser  Pro Asp Phe Thr Pro  Leu Asn Ser Phe Ser  Ala Phe Gly 
    1715                 1720                 1725             


Asn Ser  Phe Asn Leu Thr Gly  Glu Val Phe Ser Lys  Leu Gly Leu 
    1730                 1735                 1740             


Ser Arg  Ser Cys Asn Gln Ala  Ser Gln Arg Ser Trp  Asn Glu Phe 
    1745                 1750                 1755             


Asn Ser  Gly Pro Ser Tyr Leu  Trp Glu Ser Pro Ala  Thr Asp Pro 
    1760                 1765                 1770             


Ser Pro  Ser Trp Pro Ala Ser  Ser Gly Ser Pro Thr  His Thr Ala 
    1775                 1780                 1785             


Thr Ser  Val Leu Gly Asn Thr  Ser Gly Leu Trp Ser  Thr Thr Pro 
    1790                 1795                 1800             


Phe Ser  Ser Ser Ile Trp Ser  Ser Asn Leu Ser Ser  Ala Leu Pro 
    1805                 1810                 1815             


Phe Thr  Thr Pro Ala Asn Thr  Leu Ala Ser Ile Gly  Leu Met Gly 
    1820                 1825                 1830             


Thr Glu  Asn Ser Pro Ala Pro  His Ala Pro Ser Thr  Ser Ser Pro 
    1835                 1840                 1845             


Ala Asp  Asp Leu Gly Gln Thr  Tyr Asn Pro Trp Arg  Ile Trp Ser 
    1850                 1855                 1860             


Pro Thr  Ile Gly Arg Arg Ser  Ser Asp Pro Trp Ser  Asn Ser His 
    1865                 1870                 1875             


Phe Pro  His Glu Asn 
    1880             


<210>  53
<211>  807
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(807)
<223>  EPC2

<400>  53

Met Ser Lys Leu Ser Phe Arg Ala Arg Ala Leu Asp Ala Ala Lys Pro 
1               5                   10                  15      


Leu Pro Ile Tyr Arg Gly Lys Asp Met Pro Asp Leu Asn Asp Cys Val 
            20                  25                  30          


Ser Ile Asn Arg Ala Val Pro Gln Met Pro Thr Gly Met Glu Lys Glu 
        35                  40                  45              


Glu Glu Ser Glu His His Leu Gln Arg Ala Ile Ser Ala Gln Gln Val 
    50                  55                  60                  


Phe Arg Glu Lys Lys Glu Ser Met Val Ile Pro Val Pro Glu Ala Glu 
65                  70                  75                  80  


Ser Asn Val Asn Tyr Tyr Asn Arg Leu Tyr Lys Gly Glu Phe Lys Gln 
                85                  90                  95      


Pro Lys Gln Phe Ile His Ile Gln Pro Phe Asn Leu Asp Asn Glu Gln 
            100                 105                 110         


Pro Asp Tyr Asp Met Asp Ser Glu Asp Glu Thr Leu Leu Asn Arg Leu 
        115                 120                 125             


Asn Arg Lys Met Glu Ile Lys Pro Leu Gln Phe Glu Ile Met Ile Asp 
    130                 135                 140                 


Arg Leu Glu Lys Ala Ser Ser Asn Gln Leu Val Thr Leu Gln Glu Ala 
145                 150                 155                 160 


Lys Leu Leu Leu Asn Glu Asp Asp Tyr Leu Ile Lys Ala Val Tyr Asp 
                165                 170                 175     


Tyr Trp Val Arg Lys Arg Lys Asn Cys Arg Gly Pro Ser Leu Ile Pro 
            180                 185                 190         


Gln Ile Lys Gln Glu Lys Arg Asp Gly Ser Thr Asn Asn Asp Pro Tyr 
        195                 200                 205             


Val Ala Phe Arg Arg Arg Thr Glu Lys Met Gln Thr Arg Lys Asn Arg 
    210                 215                 220                 


Lys Asn Asp Glu Ala Ser Tyr Glu Lys Met Leu Lys Leu Arg Arg Glu 
225                 230                 235                 240 


Phe Ser Arg Ala Ile Thr Ile Leu Glu Met Ile Lys Arg Arg Glu Lys 
                245                 250                 255     


Thr Lys Arg Glu Leu Leu His Leu Thr Leu Glu Val Val Glu Lys Arg 
            260                 265                 270         


Tyr His Leu Gly Asp Tyr Gly Gly Glu Ile Leu Asn Glu Val Lys Ile 
        275                 280                 285             


Ser Arg Ser Glu Lys Glu Leu Tyr Ala Thr Pro Ala Thr Leu His Asn 
    290                 295                 300                 


Gly Asn His His Lys Val Gln Glu Cys Lys Thr Lys His Pro His His 
305                 310                 315                 320 


Leu Ser Leu Lys Glu Glu Ala Ser Asp Val Val Arg Gln Lys Lys Lys 
                325                 330                 335     


Tyr Pro Lys Lys Pro Lys Ala Glu Ala Leu Ile Thr Ser Gln Gln Pro 
            340                 345                 350         


Thr Pro Glu Thr Leu Pro Val Ile Asn Lys Ser Asp Ile Lys Gln Tyr 
        355                 360                 365             


Asp Phe His Ser Ser Asp Glu Asp Glu Phe Pro Gln Val Leu Ser Pro 
    370                 375                 380                 


Val Ser Glu Pro Glu Glu Glu Asn Asp Pro Asp Gly Pro Cys Ala Phe 
385                 390                 395                 400 


Arg Arg Arg Ala Gly Cys Gln Tyr Tyr Ala Pro Arg Leu Asp Gln Ala 
                405                 410                 415     


Asn His Ser Cys Glu Asn Ser Glu Leu Ala Asp Leu Asp Lys Leu Arg 
            420                 425                 430         


Tyr Arg His Cys Leu Thr Thr Leu Thr Val Pro Arg Arg Cys Ile Gly 
        435                 440                 445             


Phe Ala Arg Arg Arg Ile Gly Arg Gly Gly Arg Val Ile Met Asp Arg 
    450                 455                 460                 


Ile Ser Thr Glu His Asp Pro Val Leu Lys Gln Ile Asp Pro Glu Met 
465                 470                 475                 480 


Leu Asn Ser Phe Ser Ser Ser Ser Gln Thr Ile Asp Phe Ser Ser Asn 
                485                 490                 495     


Phe Ser Arg Thr Asn Ala Ser Ser Lys His Cys Glu Asn Arg Leu Ser 
            500                 505                 510         


Leu Ser Glu Ile Leu Ser Asn Ile Arg Ser Cys Arg Leu Gln Cys Phe 
        515                 520                 525             


Gln Pro Arg Leu Leu Asn Leu Gln Asp Ser Asp Ser Glu Glu Cys Thr 
    530                 535                 540                 


Ser Arg Lys Pro Gly Gln Thr Val Asn Asn Lys Arg Val Ser Ala Ala 
545                 550                 555                 560 


Ser Val Ala Leu Leu Asn Thr Ser Lys Asn Gly Ile Ser Val Thr Gly 
                565                 570                 575     


Gly Ile Thr Glu Glu Gln Phe Gln Thr His Gln Gln Gln Leu Val Gln 
            580                 585                 590         


Met Gln Arg Gln Gln Leu Ala Gln Leu Gln Gln Lys Gln Gln Ser Gln 
        595                 600                 605             


His Ser Ser Gln Gln Thr His Pro Lys Ala Gln Gly Ser Ser Thr Ser 
    610                 615                 620                 


Asp Cys Met Ser Lys Thr Leu Asp Ser Ala Ser Ala His Phe Ala Ala 
625                 630                 635                 640 


Ser Ala Val Val Ser Ala Pro Val Pro Ser Arg Ser Glu Val Ala Lys 
                645                 650                 655     


Glu Gln Asn Thr Gly His Asn Asn Ile Asn Gly Val Val Gln Pro Ser 
            660                 665                 670         


Gly Thr Ser Lys Thr Leu Tyr Ser Thr Asn Met Ala Leu Ser Ser Ser 
        675                 680                 685             


Pro Gly Ile Ser Ala Val Gln Leu Val Arg Thr Val Gly His Thr Thr 
    690                 695                 700                 


Thr Asn His Leu Ile Pro Ala Leu Cys Thr Ser Ser Pro Gln Thr Leu 
705                 710                 715                 720 


Pro Met Asn Asn Ser Cys Leu Thr Asn Ala Val His Leu Asn Asn Val 
                725                 730                 735     


Ser Val Val Ser Pro Val Asn Val His Ile Asn Thr Arg Thr Ser Ala 
            740                 745                 750         


Pro Ser Pro Thr Ala Leu Lys Leu Ala Thr Val Ala Ala Ser Met Asp 
        755                 760                 765             


Arg Val Pro Lys Val Thr Pro Ser Ser Ala Ile Ser Ser Ile Ala Arg 
    770                 775                 780                 


Glu Asn His Glu Pro Glu Arg Leu Gly Leu Asn Gly Ile Ala Glu Thr 
785                 790                 795                 800 


Thr Val Ala Met Glu Val Thr 
                805         


<210>  54
<211>  617
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(617)
<223>  ZNF813

<400>  54

Met Ala Leu Pro Gln Gly Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Gln Glu Glu Trp Lys Cys Leu Asp Pro Ala Gln Arg Thr Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Val Ser Leu Asp 
        35                  40                  45              


Ile Ser Ser Lys Cys Met Met Lys Glu Phe Ser Ser Thr Ala Gln Gly 
    50                  55                  60                  


Asn Arg Glu Val Ile His Thr Gly Thr Leu Gln Arg His Glu Ser His 
65                  70                  75                  80  


His Thr Gly Asp Phe Arg Phe Gln Glu Ile Asp Lys Asp Ile His Asn 
                85                  90                  95      


Leu Glu Phe Gln Trp Gln Glu Asp Glu Arg Asn Ser His Glu Ala Pro 
            100                 105                 110         


Met Thr Glu Ile Lys Lys Leu Thr Gly Ser Ala Asp Arg Tyr Asp Gln 
        115                 120                 125             


Arg His Ala Gly Asn Lys Pro Ile Lys Asp Gln Leu Gly Ser Ser Phe 
    130                 135                 140                 


His Ser His Leu Pro Glu Leu His Met Phe Gln Thr Gln Gly Lys Ile 
145                 150                 155                 160 


Gly Asn Gln Val Glu Lys Ser Ile Asn Asp Ala Ser Ser Ile Ser Thr 
                165                 170                 175     


Ser Gln Arg Ile Ser Cys Arg Pro Lys Thr His Ile Ser Asn Asn Tyr 
            180                 185                 190         


Gly Asn Asn Phe Arg Asn Ser Ser Leu Leu Thr Gln Lys Gln Glu Val 
        195                 200                 205             


His Met Arg Glu Lys Ser Phe Gln Cys Asn Glu Ser Gly Lys Ala Phe 
    210                 215                 220                 


Asn Tyr Ser Ser Leu Leu Arg Lys His Gln Ile Ile His Leu Gly Glu 
225                 230                 235                 240 


Lys Gln Tyr Lys Cys Asp Val Cys Gly Lys Val Phe Asn Arg Lys Arg 
                245                 250                 255     


Asn Leu Val Cys His Arg Arg Cys His Thr Gly Glu Lys Pro Tyr Arg 
            260                 265                 270         


Cys Asn Glu Cys Gly Lys Thr Phe Ser Gln Thr Tyr Ser Leu Thr Cys 
        275                 280                 285             


His Arg Arg Leu His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys 
    290                 295                 300                 


Asp Lys Ala Phe Ser Phe Lys Ser Asn Leu Lys Arg His Arg Arg Ile 
305                 310                 315                 320 


His Ala Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Thr Phe 
                325                 330                 335     


Ser Gln Thr Ser Ser Leu Thr Cys His Arg Arg Leu His Thr Gly Glu 
            340                 345                 350         


Lys Pro Phe Lys Cys Asn Glu Cys Gly Lys Thr Phe Ser Arg Lys Ser 
        355                 360                 365             


Ser Leu Thr Cys His His Arg Leu His Thr Gly Glu Lys Pro Tyr Lys 
    370                 375                 380                 


Cys Asn Glu Cys Gly Lys Thr Phe Ser Gln Glu Leu Thr Leu Lys Cys 
385                 390                 395                 400 


His Arg Arg Leu His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys 
                405                 410                 415     


Gly Lys Val Phe Asn Lys Lys Ala Asn Leu Ala Arg His His Arg Leu 
            420                 425                 430         


His Ser Gly Glu Lys Pro Tyr Lys Cys Thr Glu Cys Val Lys Thr Phe 
        435                 440                 445             


Ser Arg Asn Ser Ala Leu Val Ile His Lys Ala Ile His Ile Gly Glu 
    450                 455                 460                 


Lys Arg Tyr Lys Cys Asn Glu Cys Gly Lys Thr Phe Ser Arg Ile Ser 
465                 470                 475                 480 


Ala Leu Val Ile His Thr Ala Ile His Thr Gly Glu Lys Pro Tyr Lys 
                485                 490                 495     


Cys Asn Glu Cys Gly Lys Gly Phe Asn Arg Lys Thr His Leu Ala Cys 
            500                 505                 510         


His His Arg Leu His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys 
        515                 520                 525             


Gly Lys Val Phe Asn Arg Lys Thr His Leu Ala His His His Arg Leu 
    530                 535                 540                 


His Thr Gly Asp Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe 
545                 550                 555                 560 


Asn Gln Lys Ala His Leu Ala Arg His His Arg Leu His Thr Gly Glu 
                565                 570                 575     


Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe Asn Gln Lys Ala 
            580                 585                 590         


Asn Leu Ala Arg His His Arg Leu His Thr Gly Glu Lys Pro Tyr Lys 
        595                 600                 605             


Phe Asn Glu Cys Gly Lys Ala Phe Asn 
    610                 615         


<210>  55
<211>  741
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(741)
<223>  ZBTB20 isoform 1

<400>  55

Met Leu Glu Arg Lys Lys Pro Lys Thr Ala Glu Asn Gln Lys Ala Ser 
1               5                   10                  15      


Glu Glu Asn Glu Ile Thr Gln Pro Gly Gly Ser Ser Ala Lys Pro Gly 
            20                  25                  30          


Leu Pro Cys Leu Asn Phe Glu Ala Val Leu Ser Pro Asp Pro Ala Leu 
        35                  40                  45              


Ile His Ser Thr His Ser Leu Thr Asn Ser His Ala His Thr Gly Ser 
    50                  55                  60                  


Ser Asp Cys Asp Ile Ser Cys Lys Gly Met Thr Glu Arg Ile His Ser 
65                  70                  75                  80  


Ile Asn Leu His Asn Phe Ser Asn Ser Val Leu Glu Thr Leu Asn Glu 
                85                  90                  95      


Gln Arg Asn Arg Gly His Phe Cys Asp Val Thr Val Arg Ile His Gly 
            100                 105                 110         


Ser Met Leu Arg Ala His Arg Cys Val Leu Ala Ala Gly Ser Pro Phe 
        115                 120                 125             


Phe Gln Asp Lys Leu Leu Leu Gly Tyr Ser Asp Ile Glu Ile Pro Ser 
    130                 135                 140                 


Val Val Ser Val Gln Ser Val Gln Lys Leu Ile Asp Phe Met Tyr Ser 
145                 150                 155                 160 


Gly Val Leu Arg Val Ser Gln Ser Glu Ala Leu Gln Ile Leu Thr Ala 
                165                 170                 175     


Ala Ser Ile Leu Gln Ile Lys Thr Val Ile Asp Glu Cys Thr Arg Ile 
            180                 185                 190         


Val Ser Gln Asn Val Gly Asp Val Phe Pro Gly Ile Gln Asp Ser Gly 
        195                 200                 205             


Gln Asp Thr Pro Arg Gly Thr Pro Glu Ser Gly Thr Ser Gly Gln Ser 
    210                 215                 220                 


Ser Asp Thr Glu Ser Gly Tyr Leu Gln Ser His Pro Gln His Ser Val 
225                 230                 235                 240 


Asp Arg Ile Tyr Ser Ala Leu Tyr Ala Cys Ser Met Gln Asn Gly Ser 
                245                 250                 255     


Gly Glu Arg Ser Phe Tyr Ser Gly Ala Val Val Ser His His Glu Thr 
            260                 265                 270         


Ala Leu Gly Leu Pro Arg Asp His His Met Glu Asp Pro Ser Trp Ile 
        275                 280                 285             


Thr Arg Ile His Glu Arg Ser Gln Gln Met Glu Arg Tyr Leu Ser Thr 
    290                 295                 300                 


Thr Pro Glu Thr Thr His Cys Arg Lys Gln Pro Arg Pro Val Arg Ile 
305                 310                 315                 320 


Gln Thr Leu Val Gly Asn Ile His Ile Lys Gln Glu Met Glu Asp Asp 
                325                 330                 335     


Tyr Asp Tyr Tyr Gly Gln Gln Arg Val Gln Ile Leu Glu Arg Asn Glu 
            340                 345                 350         


Ser Glu Glu Cys Thr Glu Asp Thr Asp Gln Ala Glu Gly Thr Glu Ser 
        355                 360                 365             


Glu Pro Lys Gly Glu Ser Phe Asp Ser Gly Val Ser Ser Ser Ile Gly 
    370                 375                 380                 


Thr Glu Pro Asp Ser Val Glu Gln Gln Phe Gly Pro Gly Ala Ala Arg 
385                 390                 395                 400 


Asp Ser Gln Ala Glu Pro Thr Gln Pro Glu Gln Ala Ala Glu Ala Pro 
                405                 410                 415     


Ala Glu Gly Gly Pro Gln Thr Asn Gln Leu Glu Thr Gly Ala Ser Ser 
            420                 425                 430         


Pro Glu Arg Ser Asn Glu Val Glu Met Asp Ser Thr Val Ile Thr Val 
        435                 440                 445             


Ser Asn Ser Ser Asp Lys Ser Val Leu Gln Gln Pro Ser Val Asn Thr 
    450                 455                 460                 


Ser Ile Gly Gln Pro Leu Pro Ser Thr Gln Leu Tyr Leu Arg Gln Thr 
465                 470                 475                 480 


Glu Thr Leu Thr Ser Asn Leu Arg Met Pro Leu Thr Leu Thr Ser Asn 
                485                 490                 495     


Thr Gln Val Ile Gly Thr Ala Gly Asn Thr Tyr Leu Pro Ala Leu Phe 
            500                 505                 510         


Thr Thr Gln Pro Ala Gly Ser Gly Pro Lys Pro Phe Leu Phe Ser Leu 
        515                 520                 525             


Pro Gln Pro Leu Ala Gly Gln Gln Thr Gln Phe Val Thr Val Ser Gln 
    530                 535                 540                 


Pro Gly Leu Ser Thr Phe Thr Ala Gln Leu Pro Ala Pro Gln Pro Leu 
545                 550                 555                 560 


Ala Ser Ser Ala Gly His Ser Thr Ala Ser Gly Gln Gly Glu Lys Lys 
                565                 570                 575     


Pro Tyr Glu Cys Thr Leu Cys Asn Lys Thr Phe Thr Ala Lys Gln Asn 
            580                 585                 590         


Tyr Val Lys His Met Phe Val His Thr Gly Glu Lys Pro His Gln Cys 
        595                 600                 605             


Ser Ile Cys Trp Arg Ser Phe Ser Leu Lys Asp Tyr Leu Ile Lys His 
    610                 615                 620                 


Met Val Thr His Thr Gly Val Arg Ala Tyr Gln Cys Ser Ile Cys Asn 
625                 630                 635                 640 


Lys Arg Phe Thr Gln Lys Ser Ser Leu Asn Val His Met Arg Leu His 
                645                 650                 655     


Arg Gly Glu Lys Ser Tyr Glu Cys Tyr Ile Cys Lys Lys Lys Phe Ser 
            660                 665                 670         


His Lys Thr Leu Leu Glu Arg His Val Ala Leu His Ser Ala Ser Asn 
        675                 680                 685             


Gly Thr Pro Pro Ala Gly Thr Pro Pro Gly Ala Arg Ala Gly Pro Pro 
    690                 695                 700                 


Gly Val Val Ala Cys Thr Glu Gly Thr Thr Tyr Val Cys Ser Val Cys 
705                 710                 715                 720 


Pro Ala Lys Phe Asp Gln Ile Glu Gln Phe Asn Asp His Met Arg Met 
                725                 730                 735     


His Val Ser Asp Gly 
            740     


