                               SEQUENCE LISTING

<110> THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
 
<120> ADENO-ASSOCIATED VIRAL (AAV) VECTORS FOR TISSUE-TARGETED 
      EXPRESSION OF THERAPEUTIC GENES

<130> 40175-0036WO1

<140> PCT/US2022/073051
<141> 2022-06-21

<150> 63/213,045
<151> 2021-06-21

<160> 115   

<170> PatentIn version 3.5

<210> 1
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> AAV9 viral vector

<400> 1
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 2
<211> 742
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> AAV9.CPP16 viral vector

<400> 2
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Thr Val Ser Ala 
            580                 585                 590         


Leu Lys Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile Leu 
        595                 600                 605             


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
    610                 615                 620                 


Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu 
625                 630                 635                 640 


Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
                645                 650                 655     


Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys 
            660                 665                 670         


Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu 
        675                 680                 685             


Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
    690                 695                 700                 


Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala 
705                 710                 715                 720 


Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg 
                725                 730                 735     


Tyr Leu Thr Arg Asn Leu 
            740         


<210> 3
<211> 743
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> AAV9.CPP21 viral vector

<400> 3
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Thr Val Ser Ala 
            580                 585                 590         


Leu Phe Lys Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210> 4
<211> 479
<212> DNA
<213> Homo sapiens

<400> 4
acgggtggca tccctgtgac ccctccccag tgcctctcct ggccctggaa gttgccactc       60

cagtgcccac cagccttgtc ctaataaaat taagttgcat cattttgtct gactaggtgt      120

ccttctataa tattatgggg tggagggggg tggtatggag caaggggcaa gttgggaaga      180

caacctgtag ggcctgcggg gtctattggg aaccaagctg gagtgcagtg gcacaatctt      240

ggctcactgc aatctccgcc tcctgggttc aagcgattct cctgcctcag cctcccgagt      300

tgttgggatt ccaggcatgc atgaccaggc tcagctaatt tttgtttttt tggtagagac      360

ggggtttcac catattggcc aggctggtct ccaactccta atctcaggtg atctacccac      420

cttggcctcc caaattgctg ggattacagg cgtgaaccac tgctcccttc cctgtcctt       479


<210> 5
<211> 135
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct      120

tatcatgtct ggatc                                                       135


<210> 6
<211> 228
<212> DNA
<213> Bos taurus

<400> 6
cgactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga       60

ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt      120

gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg      180

attgggaaga caatagcagg catgctgggg atgcggtggg ctctatgg                   228


<210> 7
<211> 527
<212> DNA
<213> Oryctolagus cuniculus

<400> 7
ttcactcctc aggtgcaggc tgcctatcag aaggtggtgg ctggtgtggc caatgccctg       60

gctcacaaat accactgaga tctttttccc tctgccaaaa attatgggga catcatgaag      120

ccccttgagc atctgacttc tggctaataa aggaaattta ttttcattgc aatagtgtgt      180

tggaattttt tgtgtctctc actcggaagg acatatggga gggcaaatca tttaaaacat      240

cagaatgagt atttggttta gagtttggca acatatgccc atatgctggc tgccatgaac      300

aaaggttggc tataaagagg tcatcagtat atgaaacagc cccctgctgt ccattcctta      360

ttccatagaa aagccttgac ttgaggttag atttttttta tattttgttt tgtgttattt      420

ttttctttaa catccctaaa attttcctta catgttttac tagccagatt tttcctcctc      480

tcctgactac tcccagtcat agctgtccct cttctcttat ggagatc                    527


<210> 8
<211> 25
<212> PRT
<213> Homo sapiens

<400> 8
Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser Met 
            20                  25  


<210> 9
<211> 19
<212> PRT
<213> Homo sapiens

<400> 9
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210> 10
<211> 21
<212> PRT
<213> Homo sapiens

<400> 10
Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp 
1               5                   10                  15      


Pro Met Val Trp Ala 
            20      


<210> 11
<211> 22
<212> PRT
<213> Homo sapiens

<400> 11
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210> 12
<211> 16
<212> PRT
<213> Homo sapiens

<400> 12
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


<210> 13
<211> 23
<212> PRT
<213> Homo sapiens

<400> 13
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser 
            20              


<210> 14
<211> 18
<212> PRT
<213> Homo sapiens

<400> 14
Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly 
        


<210> 15
<211> 15
<212> PRT
<213> Homo sapiens

<400> 15
Met Asn Leu Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Val Ala 
1               5                   10                  15  


<210> 16
<211> 20
<212> PRT
<213> Homo sapiens

<400> 16
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210> 17
<211> 16
<212> PRT
<213> Homo sapiens

<400> 17
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Ser Ser Ala Tyr Ser 
1               5                   10                  15      


<210> 18
<211> 24
<212> PRT
<213> Homo sapiens

<400> 18
Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala 
            20                  


<210> 19
<211> 24
<212> PRT
<213> Homo sapiens

<400> 19
Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala 
            20                  


<210> 20
<211> 22
<212> DNA
<213> Homo sapiens

<400> 20
atcaaggtcc gctgtgaaca cg                                                22


<210> 21
<211> 22
<212> DNA
<213> Homo sapiens

<400> 21
caaacaccat tgtcacactc ca                                                22


<210> 22
<211> 22
<212> DNA
<213> Homo sapiens

<400> 22
ccaaacactg ctgggtaaga cg                                                22


<210> 23
<211> 23
<212> DNA
<213> Mus musculus

<400> 23
tatgggcata taaagaagta tgt                                               23


<210> 24
<211> 22
<212> DNA
<213> Homo sapiens

<400> 24
atgggcatat aaagaagtat gt                                                22


<210> 25
<211> 22
<212> RNA
<213> Homo sapiens

<400> 25
cguguucaca gcggaccuug au                                                22


<210> 26
<211> 22
<212> RNA
<213> Homo sapiens

<400> 26
uggaguguga caaugguguu ug                                                22


<210> 27
<211> 22
<212> RNA
<213> Homo sapiens

<400> 27
cgucuuaccc agcaguguuu gg                                                22


<210> 28
<211> 23
<212> RNA
<213> Mus musculus

<400> 28
acauacuucu uuauaugccc aua                                               23


<210> 29
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Val Pro Ala Leu Arg 
1               5   


<210> 30
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Val Ser Ala Leu Lys 
1               5   


<210> 31
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Thr Val Pro Ala Leu Arg 
1               5       


<210> 32
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Thr Val Ser Ala Leu Lys 
1               5       


<210> 33
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Phe Thr Val Ser Ala Leu Lys 
1               5           


<210> 34
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Leu Thr Val Ser Ala Leu Lys 
1               5           


<210> 35
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Thr Phe Val Ser Ala Leu Lys 
1               5           


<210> 36
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Thr Val Ser Ala Leu Phe Lys 
1               5           


<210> 37
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Thr Val Pro Ala Leu Phe Arg 
1               5           


<210> 38
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Thr Val Pro Met Leu Phe Lys 
1               5           


<210> 39
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Thr Val Pro Thr Leu Phe Lys 
1               5           


<210> 40
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Thr Val Pro Met Leu Lys 
1               5       


<210> 41
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Thr Val Pro Thr Leu Lys 
1               5       


<210> 42
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Val Pro Met Leu Lys 
1               5   


<210> 43
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Val Pro Thr Leu Lys 
1               5   


<210> 44
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Val Pro Met Leu Lys Glu 
1               5       


<210> 45
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Val Pro Thr Leu Lys Asp 
1               5       


<210> 46
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Val Pro Ala Leu Arg Asp 
1               5       


<210> 47
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Val Ser Ala Leu Lys Glu 
1               5       


<210> 48
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Val Ser Ala Leu Lys Asp 
1               5       


<210> 49
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Thr Ala Val Ser Leu Lys 
1               5       


<210> 50
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Thr Ala Leu Val Ser Lys 
1               5       


<210> 51
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Thr Val Leu Ser Ala Lys 
1               5       


<210> 52
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Thr Leu Val Ser Ala Lys 
1               5       


<210> 53
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 53
Thr Met Val Pro Leu Lys 
1               5       


<210> 54
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Thr Met Leu Val Pro Lys 
1               5       


<210> 55
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 55
Thr Val Leu Pro Met Lys 
1               5       


<210> 56
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Thr Leu Val Pro Met Lys 
1               5       


<210> 57
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 57
Thr Thr Val Pro Leu Lys 
1               5       


<210> 58
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 58
Thr Thr Leu Val Pro Lys 
1               5       


<210> 59
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Thr Val Leu Pro Thr Lys 
1               5       


<210> 60
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Thr Leu Val Pro Thr Lys 
1               5       


<210> 61
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Thr Ala Val Pro Leu Arg 
1               5       


<210> 62
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 62
Thr Ala Leu Val Pro Arg 
1               5       


<210> 63
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 63
Thr Val Leu Pro Ala Arg 
1               5       


<210> 64
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 64
Thr Leu Val Pro Ala Arg 
1               5       


<210> 65
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 65
Thr Ala Val Ser Leu Lys Glu 
1               5           


<210> 66
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 66
Thr Ala Leu Val Ser Lys Glu 
1               5           


<210> 67
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 67
Thr Val Leu Ser Ala Lys Glu 
1               5           


<210> 68
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 68
Thr Leu Val Ser Ala Lys Glu 
1               5           


<210> 69
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 69
Thr Met Val Pro Leu Lys Glu 
1               5           


<210> 70
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 70
Thr Met Leu Val Pro Lys Glu 
1               5           


<210> 71
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 71
Thr Val Leu Pro Met Lys Glu 
1               5           


<210> 72
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 72
Thr Leu Val Pro Met Lys Glu 
1               5           


<210> 73
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 73
Thr Thr Val Pro Leu Lys Asp 
1               5           


<210> 74
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 74
Thr Thr Leu Val Pro Lys Asp 
1               5           


<210> 75
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 75
Thr Val Leu Pro Thr Lys Asp 
1               5           


<210> 76
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 76
Thr Leu Val Pro Thr Lys Asp 
1               5           


<210> 77
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 77
Thr Ala Val Pro Leu Arg Asp 
1               5           


<210> 78
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 78
Thr Ala Leu Val Pro Arg Asp 
1               5           


<210> 79
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 79
Thr Val Leu Pro Ala Arg Asp 
1               5           


<210> 80
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 80
Thr Leu Val Pro Ala Arg Asp 
1               5           


<210> 81
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 81
Thr Ala Val Ser Leu Phe Lys 
1               5           


<210> 82
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 82
Thr Ala Leu Val Ser Phe Lys 
1               5           


<210> 83
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 83
Thr Val Leu Ser Ala Phe Lys 
1               5           


<210> 84
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 84
Thr Leu Val Ser Ala Phe Lys 
1               5           


<210> 85
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 85
Thr Met Val Pro Leu Phe Lys 
1               5           


<210> 86
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 86
Thr Met Leu Val Pro Phe Lys 
1               5           


<210> 87
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 87
Thr Val Leu Pro Met Phe Lys 
1               5           


<210> 88
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 88
Thr Leu Val Pro Met Phe Lys 
1               5           


<210> 89
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 89
Thr Thr Val Pro Leu Phe Lys 
1               5           


<210> 90
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 90
Thr Thr Leu Val Pro Phe Lys 
1               5           


<210> 91
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 91
Thr Val Leu Pro Thr Phe Lys 
1               5           


<210> 92
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 92
Thr Leu Val Pro Thr Phe Lys 
1               5           


<210> 93
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 93
Thr Ala Val Pro Leu Phe Arg 
1               5           


<210> 94
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 94
Thr Ala Leu Val Pro Phe Arg 
1               5           


<210> 95
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 95
Thr Val Leu Pro Ala Phe Arg 
1               5           


<210> 96
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 96
Thr Leu Val Pro Ala Phe Arg 
1               5           


<210> 97
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (2)..(2)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (3)..(3)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (4)..(4)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (5)..(5)
<223> K, R, H, D, or E

<220>
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 97
Xaa Xaa Xaa Xaa Xaa 
1               5   


<210> 98
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (3)..(3)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (4)..(4)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (5)..(5)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (6)..(6)
<223> K, R, H, D, or E

<220>
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 98
Thr Xaa Xaa Xaa Xaa Xaa 
1               5       


<210> 99
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (2)..(2)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (3)..(3)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (4)..(4)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (5)..(5)
<223> K, R, H, D, or E

<220>
<221> MOD_RES
<222> (6)..(6)
<223> E or D

<220>
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 99
Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210> 100
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> F, L, W, or Y

<220>
<221> MOD_RES
<222> (3)..(3)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (4)..(4)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (5)..(5)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (6)..(6)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (7)..(7)
<223> K, R, H, D, or E

<220>
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 100
Xaa Thr Xaa Xaa Xaa Xaa Xaa 
1               5           


<210> 101
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (3)..(3)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (4)..(4)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (5)..(5)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (6)..(6)
<223> K, R, H, D, or E

<220>
<221> MOD_RES
<222> (7)..(7)
<223> E or D

<220>
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 101
Thr Xaa Xaa Xaa Xaa Xaa Xaa 
1               5           


<210> 102
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (2)..(2)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (3)..(3)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (4)..(4)
<223> V, A, L, I, G, P, S, T, or M

<220>
<221> MOD_RES
<222> (5)..(5)
<223> K, R, H, D, or E

<220>
<221> MOD_RES
<222> (6)..(6)
<223> E or D

<220>
<221> MOD_RES
<222> (7)..(7)
<223> A or I

<220>
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 102
Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5           


<210> 103
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> S or P

<220>
<221> MOD_RES
<222> (3)..(3)
<223> A, M, or T

<220>
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 103
Val Xaa Xaa Leu 
1               


<210> 104
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> S or P

<220>
<221> MOD_RES
<222> (4)..(4)
<223> A, M, or T

<220>
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 104
Thr Val Xaa Xaa Leu 
1               5   


<210> 105
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> S or P

<220>
<221> MOD_RES
<222> (4)..(4)
<223> A, M, or T

<220>
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 105
Thr Val Xaa Xaa Leu Lys 
1               5       


<210> 106
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> S or P

<220>
<221> MOD_RES
<222> (4)..(4)
<223> A, M, or T

<220>
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 106
Thr Val Xaa Xaa Leu Phe Lys 
1               5           


<210> 107
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 107
Lys Leu Ala Ser Val Thr 
1               5       


<210> 108
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 108
Lys Phe Leu Ala Ser Val Thr 
1               5           


<210> 109
<211> 22
<212> RNA
<213> Homo sapiens

<400> 109
acauacuucu uuauaugccc au                                                22


<210> 110
<211> 22
<212> DNA
<213> Mus musculus

<400> 110
atcaaggtcc gctgtgaaca cg                                                22


<210> 111
<211> 22
<212> DNA
<213> Mus musculus

<400> 111
caaacaccat tgtcacactc ca                                                22


<210> 112
<211> 22
<212> DNA
<213> Mus musculus

<400> 112
ccaaacactg ctgggtaaga cg                                                22


<210> 113
<211> 22
<212> RNA
<213> Mus musculus

<400> 113
cguguucaca gcggaccuug au                                                22


<210> 114
<211> 22
<212> RNA
<213> Mus musculus

<400> 114
uggaguguga caaugguguu ug                                                22


<210> 115
<211> 22
<212> RNA
<213> Mus musculus

<400> 115
cgucuuaccc agcaguguuu gg                                                22


