               SEQUENCE LISTING

<110> Releviate, LLC

<120> MMP-14 ANTIBODIES AND USES THEREOF

<130> RELE-04-PCT

<150>  US 63/215,209
<151>  2021-06-21

<160> 41

<210> 1
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> immunoglobulin heavy chain CDR-H3

<400> 1
Val Lys Leu Gln Lys Asp Lys Ser His Gln Trp Ile Arg Asn Leu Val 
1               5                   10                  15      
Ala Thr Pro Tyr Gly Arg Tyr Val Met Asp Tyr 
            20                  25          

<210> 2
<211> 213
<212> PRT
<213> Artificial Sequence


<220> 
<223> immunoglobulin light chain

<400> 2
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Tyr Pro Ile Thr 
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Ser Gln Leu Lys Ser Gly Thr 
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             
Asn Arg Gly Glu Cys 
    210             

<210> 3
<211> 466
<212> PRT
<213> Artificial Sequence


<220> 
<223> immunoglobulin heavy chain

<400> 3
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Ser Ser Ser 
            20                  25                  30          
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Tyr Pro Ser Tyr Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Val Lys Leu Gln Lys Asp Lys Ser His Gln Trp Ile Arg Asn 
            100                 105                 110         
Leu Val Ala Thr Pro Tyr Gly Arg Tyr Val Met Asp Tyr Trp Gly Gln 
        115                 120                 125             
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 
Gly Lys 
465     

<210> 4
<211> 466
<212> PRT
<213> Artificial Sequence


<220> 
<223> immunoglobulin heavy chain with the YTE substitution

<400> 4
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Ser Ser Ser 
            20                  25                  30          
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Tyr Pro Ser Tyr Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Val Lys Leu Gln Lys Asp Lys Ser His Gln Trp Ile Arg Asn 
            100                 105                 110         
Leu Val Ala Thr Pro Tyr Gly Arg Tyr Val Met Asp Tyr Trp Gly Gln 
        115                 120                 125             
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile 
            260                 265                 270         
Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 
Gly Lys 
465     

<210> 5
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> signal sequence useful for secretion of immunoglobulins

<400> 5
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser 
            

<210> 6
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> signal sequence useful for secretion of immunoglobulins

<400> 6
Met Asp Leu Leu His Lys Asn Met Lys His Leu Trp Phe Phe Leu Leu 
1               5                   10                  15      
Leu Val Ala Ala Pro Arg Trp Val Leu Ser 
            20                  25      

<210> 7
<211> 22
<212> PRT
<213> Artificial Sequence


<220> 
<223> signal sequence useful for secretion of immunoglobulins

<400> 7
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      
Leu Ser Gly Ala Arg Cys 
            20          

<210> 8
<211> 213
<212> PRT
<213> Artificial Sequence


<220> 
<223> immunoglobulin light chain

<400> 8
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Tyr Pro Ile Thr 
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Ser Gln Leu Lys Ser Gly Thr 
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             
Asn Arg Gly Glu Cys 
    210             

<210> 9
<211> 213
<212> PRT
<213> Artificial Sequence


<220> 
<223> immunoglobulin light chain

<400> 9
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Tyr Pro Ile Thr 
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             
Asn Arg Gly Glu Cys 
    210             

<210> 10
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 10
Val Lys Leu Gln Lys 
1               5   

<210> 11
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 11
Lys Leu Gln Lys Asp 
1               5   

<210> 12
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 12
Leu Gln Lys Asp Lys 
1               5   

<210> 13
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 13
Gln Lys Asp Lys Ser 
1               5   

<210> 14
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 14
Lys Asp Lys Ser His 
1               5   

<210> 15
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 15
Asp Lys Ser His Gln 
1               5   

<210> 16
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 16
Lys Ser His Gln Trp 
1               5   

<210> 17
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 17
Ser His Gln Trp Ile 
1               5   

<210> 18
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 18
His Gln Trp Ile Arg 
1               5   

<210> 19
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 19
Gln Trp Ile Arg Asn 
1               5   

<210> 20
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 20
Trp Ile Arg Asn Leu 
1               5   

<210> 21
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 21
Ile Arg Asn Leu Val 
1               5   

<210> 22
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 22
Arg Asn Leu Val Ala 
1               5   

<210> 23
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 23
Asn Leu Val Ala Thr 
1               5   

<210> 24
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 24
Leu Val Ala Thr Pro 
1               5   

<210> 25
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 25
Val Ala Thr Pro Tyr 
1               5   

<210> 26
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 26
Ala Thr Pro Tyr Gly 
1               5   

<210> 27
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 27
Thr Pro Tyr Gly Arg 
1               5   

<210> 28
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 28
Pro Tyr Gly Arg Tyr 
1               5   

<210> 29
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 29
Tyr Gly Arg Tyr Val 
1               5   

<210> 30
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 30
Gly Arg Tyr Val Met 
1               5   

<210> 31
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 31
Arg Tyr Val Met Asp 
1               5   

<210> 32
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5-mer from SEQ ID NO:1

<400> 32
Tyr Val Met Asp Tyr 
1               5   

<210> 33
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> signal sequence useful for secretion of immunoglobulins

<400> 33
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly 
            20  

<210> 34
<211> 233
<212> PRT
<213> Artificial Sequence


<220> 
<223> immunoglobulin light chain having SEQ ID NO:2 with the signal
      sequence having SEQ ID NO:33

<400> 34
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              
Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  
Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly 
            100                 105                 110         
Tyr Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             
Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Ser Gln Leu 
    130                 135                 140                 
Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 
Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             
Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 
Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             

<210> 35
<211> 705
<212> DNA
<213> Artificial Sequence


<220> 
<223> exemplary DNA sequence encoding protein of SEQ ID NO:34

<400> 35
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ctccaccggc      60

gacattcaga tgacacaatc tcctagttcc ctgtccgcct ccgtcggcga tcgcgtcact     120

attacgtgtc gggcaagtca gtcggtcagc tctgctgtgg cctggtacca acaaaagcca     180

ggcaaggctc ccaaactcct gatctattcc gcctcaagct tgtactccgg cgttcctagc     240

cggttttcgg gaagccggag cggcacagat ttcaccctga caatcagcag tttgcaacca     300

gaagacttcg ctacttacta ctgccaacaa tacggatatc ccattacctt tggacaagga     360

accaaggtcg agatcaaacg tacggtggct gcaccatctg tcttcatctt cccgccatct     420

gattcccagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc     480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag     540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg     600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg     660

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt aatag                     705


<210> 36
<211> 485
<212> PRT
<213> Artificial Sequence


<220> 
<223> immunoglobulin heavy chain having SEQ ID NO:4 with a signal
      sequence having SEQ ID NO:5

<400> 36
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu 
        35                  40                  45              
Ser Ser Ser Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ala Ser Ile Tyr Pro Ser Tyr Ser Tyr Thr Tyr Tyr Ala 
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
                85                  90                  95      
Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Val Lys Leu Gln Lys Asp Lys Ser His Gln Trp 
        115                 120                 125             
Ile Arg Asn Leu Val Ala Thr Pro Tyr Gly Arg Tyr Val Met Asp Tyr 
    130                 135                 140                 
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
145                 150                 155                 160 
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
                165                 170                 175     
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
            180                 185                 190         
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
        195                 200                 205             
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
    210                 215                 220                 
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
225                 230                 235                 240 
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
                245                 250                 255     
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            260                 265                 270         
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        275                 280                 285             
Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val 
    290                 295                 300                 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
305                 310                 315                 320 
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                325                 330                 335     
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            340                 345                 350         
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        355                 360                 365             
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    370                 375                 380                 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
385                 390                 395                 400 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                405                 410                 415     
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            420                 425                 430         
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        435                 440                 445             
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    450                 455                 460                 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
465                 470                 475                 480 
Leu Ser Pro Gly Lys 
                485 

<210> 37
<211> 1461
<212> DNA
<213> Artificial Sequence


<220> 
<223> exemplary nucleotide sequence encoding SEQ ID NO:36

<400> 37
atgggatggt catgtatcat cctttttctg gtagcaactg caactggagt acatagcgag      60

gttcagctcg tggagagcgg cggcggtttg gttcaacctg gtggctccct gaggctgtcc     120

tgtgccgcct ctggctttaa cctgagtagt agcagcatgc attgggttcg ccaagcgccc     180

ggcaagggac tggaatgggt ggcctctatc tacccctctt atagctatac ttactacgct     240

gattccgtga aaggtcgctt cacaatttct gctgacacct caaaaaatac cgcttacttg     300

caaatgaatt ccctgcgggc tgaggatacg gctgtatact actgcgcccg cgtcaagctc     360

cagaaggata aaagtcacca atggatcaga aacttggtgg ccaccccata cggtagatac     420

gtgatggact attggggtca gggtaccctg gtaacagtat catcagctag caccaagggc     480

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg     540

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc     600

ctgaccagcg gcgtgcacac cttcccggcc gtcctacagt cctcaggact ctactccctc     660

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg     720

aatcacaagc ccagcaacac caaggtggac aagaaggttg agcccaaatc ttgtgacaaa     780

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc     840

ttccccccaa aacccaagga caccctctac atcacccggg agcctgaggt cacatgcgtg     900

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     960

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg    1020

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag    1080

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag    1140

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag    1200

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag    1260

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc    1320

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc    1380

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc    1440

ctgtctccgg gcaaataata g                                              1461


<210> 38
<211> 177
<212> PRT
<213> Homo sapiens


<220> 
<223> human MMP14 catalytic domain

<400> 38
Tyr Ala Ile Gln Gly Leu Lys Trp Gln His Asn Glu Ile Thr Phe Cys 
1               5                   10                  15      
Ile Gln Asn Tyr Thr Pro Lys Val Gly Glu Tyr Ala Thr Phe Glu Ala 
            20                  25                  30          
Ile Arg Lys Ala Phe Arg Val Trp Glu Ser Ala Thr Pro Leu Arg Phe 
        35                  40                  45              
Arg Glu Val Pro Tyr Ala Tyr Ile Arg Glu Gly His Glu Lys Gln Ala 
    50                  55                  60                  
Asp Ile Met Ile Leu Phe Ala Glu Gly Phe His Gly Asp Ser Thr Pro 
65                  70                  75                  80  
Phe Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro 
                85                  90                  95      
Asn Ile Gly Gly Asp Thr His Phe Asp Ser Ala Glu Pro Trp Thr Val 
            100                 105                 110         
Gln Asn Glu Asp Leu Asn Gly Asn Asp Ile Phe Leu Val Ala Val His 
        115                 120                 125             
Glu Leu Gly His Ala Leu Gly Leu Glu His Ser Asn Asp Pro Ser Ala 
    130                 135                 140                 
Ile Met Ala Pro Phe Tyr Gln Trp Met Asp Thr Glu Asn Phe Val Leu 
145                 150                 155                 160 
Pro Asp Asp Asp Arg Arg Gly Ile Gln Gln Leu Tyr Gly Asp Lys Ser 
                165                 170                 175     
Gly 
    

<210> 39
<211> 177
<212> PRT
<213> Macaca mulatta


<220> 
<223> monkey MMP14 catalytic domain

<400> 39
Tyr Ala Ile Gln Gly Leu Lys Trp Gln His Asn Glu Ile Thr Phe Cys 
1               5                   10                  15      
Ile Gln Asn Tyr Thr Pro Lys Val Gly Glu Tyr Ala Thr Phe Glu Ala 
            20                  25                  30          
Ile Arg Lys Ala Phe Arg Val Trp Glu Ser Ala Thr Pro Leu Arg Phe 
        35                  40                  45              
Arg Glu Val Pro Tyr Ala Tyr Ile Arg Glu Gly His Glu Lys Gln Ala 
    50                  55                  60                  
Asp Ile Met Ile Leu Phe Ala Glu Gly Phe His Gly Asp Ser Thr Pro 
65                  70                  75                  80  
Phe Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro 
                85                  90                  95      
Asn Ile Gly Gly Asp Thr His Phe Asp Ser Ala Glu Pro Trp Thr Val 
            100                 105                 110         
Gln Asn Glu Asp Leu Asn Gly Asn Asp Ile Phe Leu Val Ala Val His 
        115                 120                 125             
Glu Leu Gly His Ala Leu Gly Leu Glu His Ser Asn Asp Pro Ser Ala 
    130                 135                 140                 
Ile Met Ala Pro Phe Tyr Gln Trp Met Asp Thr Glu Asn Phe Val Leu 
145                 150                 155                 160 
Pro Asp Asp Asp Arg Arg Gly Ile Gln Gln Leu Tyr Gly Ser Lys Ser 
                165                 170                 175     
Gly 
    

<210> 40
<211> 177
<212> PRT
<213> Mus musculus


<220> 
<223> murine MMP14 catalytic domain

<400> 40
Tyr Ala Ile Gln Gly Leu Lys Trp Gln His Asn Glu Ile Thr Phe Cys 
1               5                   10                  15      
Ile Gln Asn Tyr Thr Pro Lys Val Gly Glu Tyr Ala Thr Tyr Glu Ala 
            20                  25                  30          
Ile Arg Lys Ala Phe Arg Val Trp Glu Ser Ala Thr Pro Leu Arg Phe 
        35                  40                  45              
Arg Glu Val Pro Tyr Ala Tyr Ile Arg Glu Gly His Glu Lys Gln Ala 
    50                  55                  60                  
Asp Ile Met Ile Phe Phe Ala Glu Gly Phe His Gly Asp Ser Thr Pro 
65                  70                  75                  80  
Phe Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro 
                85                  90                  95      
Asn Ile Gly Gly Asp Thr His Phe Asp Ser Ala Glu Pro Trp Thr Val 
            100                 105                 110         
Arg Asn Glu Asp Leu Asn Gly Asn Asp Ile Phe Leu Val Ala Val His 
        115                 120                 125             
Glu Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asp Pro Ser Ala 
    130                 135                 140                 
Ile Met Ala Pro Phe Tyr Gln Trp Met Asp Thr Glu Asn Phe Val Leu 
145                 150                 155                 160 
Pro Asp Asp Asp Arg Arg Gly Ile Gln Gln Leu Tyr Gly Gly Glu Ser 
                165                 170                 175     
Gly 
    

<210> 41
<211> 177
<212> PRT
<213> Rattus norvegicus


<220> 
<223> rat MMP14 catalytic domain

<400> 41
Tyr Ala Ile Gln Gly Leu Lys Trp Gln Tyr Asn Glu Ile Thr Phe Cys 
1               5                   10                  15      
Ile Gln Asn Tyr Thr Pro Lys Val Gly Glu Tyr Ala Thr Tyr Glu Ala 
            20                  25                  30          
Ile Arg Lys Ala Phe Arg Val Trp Glu Ser Ala Thr Pro Leu Arg Phe 
        35                  40                  45              
Arg Glu Val Pro Tyr Ala Tyr Ile Arg Glu Gly His Glu Lys Gln Ala 
    50                  55                  60                  
Asp Ile Met Ile Phe Phe Ala Glu Gly Phe His Gly Asp Ser Thr Pro 
65                  70                  75                  80  
Phe Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro 
                85                  90                  95      
Asn Ile Gly Gly Asp Thr His Phe Asp Ser Ala Glu Pro Trp Thr Val 
            100                 105                 110         
Gly Asn Glu Asp Leu Asn Gly Asn Asp Ile Phe Leu Val Ala Val His 
        115                 120                 125             
Glu Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asp Pro Ser Ala 
    130                 135                 140                 
Ile Met Ala Pro Phe Tyr Gln Trp Met Asp Thr Glu Asn Phe Val Leu 
145                 150                 155                 160 
Pro Asp Asp Asp Arg Arg Gly Ile Gln Gln Leu Tyr Gly Ser Glu Ser 
                165                 170                 175     
Gly 
    

