                         SEQUENCE LISTING

<110>  AvroBio, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR TREATMENT OF GAUCHER DISEASE

<130>  51182-034WO2

<150>  US 63/213,885
<151>  2021-06-23

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln 
    530                 535     


<210>  2
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln Gly Gly Gly Gly Ala Gly Gly Gly 
    530                 535                 540                 


Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Pro 
545                 550                 555                 560 


Ser Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly 
                565                 570                 575     


Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Ala Arg 
            580                 585                 590         


Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala 
        595                 600                 605             


Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu 
    610                 615                 620     


<210>  3
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln Gly Ala Pro Gly Gly Gly Ser Pro 
    530                 535                 540                 


Ala Pro Ala Pro Thr Pro Ala Pro Ala Pro Thr Pro Ala Pro Ala Gly 
545                 550                 555                 560 


Gly Gly Pro Ser Gly Ala Pro Leu Cys Gly Gly Glu Leu Val Asp Thr 
                565                 570                 575     


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            580                 585                 590         


Ser Arg Val Ser Ala Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        595                 600                 605             


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    610                 615                 620                 


Lys Ser Glu 
625         


<210>  4
<211>  652
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln Gly Ala Pro Gly Gly Ser Pro Ala 
    530                 535                 540                 


Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 
545                 550                 555                 560 


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
                565                 570                 575     


Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Gly Pro Ser Gly Ala Pro 
            580                 585                 590         


Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp 
        595                 600                 605             


Arg Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Ala Arg Ser 
    610                 615                 620                 


Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu 
625                 630                 635                 640 


Leu Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu 
                645                 650         


<210>  5
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Arg Pro Cys Ile Pro Lys Ser 
            20                  25                  30          


Phe Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp 
        35                  40                  45              


Ser Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr 
    50                  55                  60                  


Glu Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile 
65                  70                  75                  80  


Gln Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu 
                85                  90                  95      


Gln Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala 
            100                 105                 110         


Ala Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu 
        115                 120                 125             


Leu Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg 
    130                 135                 140                 


Val Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala 
145                 150                 155                 160 


Asp Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu 
                165                 170                 175     


Asp Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala 
            180                 185                 190         


Gln Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp 
        195                 200                 205             


Leu Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln 
    210                 215                 220                 


Pro Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe 
225                 230                 235                 240 


Leu Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala 
                245                 250                 255     


Glu Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys 
            260                 265                 270         


Leu Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu 
        275                 280                 285             


Gly Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met 
    290                 295                 300                 


Leu Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu 
305                 310                 315                 320 


Thr Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp 
                325                 330                 335     


Tyr Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His 
            340                 345                 350         


Arg Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly 
        355                 360                 365             


Ser Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly 
    370                 375                 380                 


Met Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val 
385                 390                 395                 400 


Gly Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn 
                405                 410                 415     


Trp Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys 
            420                 425                 430         


Asp Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser 
        435                 440                 445             


Lys Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln 
    450                 455                 460                 


Lys Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala 
465                 470                 475                 480 


Val Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile 
                485                 490                 495     


Lys Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser 
            500                 505                 510         


Ile His Thr Tyr Leu Trp Arg Arg Gln 
        515                 520     


<210>  6
<211>  2275
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (2005)..(2005)
<223>  n is a, c, g, or t

<400>  6
gctaacctag tgcctatagc taaggcaggt acctgcatcc ttgtttttgt ttagtggatc       60

ctctatcctt cagagactct ggaacccctg tggtcttctc ttcatctaat gaccctgagg      120

ggatggagtt ttcaagtcct tccagagagg aatgtcccaa gcctttgagt agggtaagca      180

tcatggctgg cagcctcaca ggtttgcttc tacttcaggc agtgtcgtgg gcatcaggtg      240

cccgcccctg catccctaaa agcttcggct acagctcggt ggtgtgtgtc tgcaatgcca      300

catactgtga ctcctttgac cccccgacct ttcctgccct tggtaccttc agccgctatg      360

agagtacacg cagtgggcga cggatggagc tgagtatggg gcccatccag gctaatcaca      420

cgggcacagg cctgctactg accctgcagc cagaacagaa gttccagaaa gtgaagggat      480

ttggaggggc catgacagat gctgctgctc tcaacatcct tgccctgtca ccccctgccc      540

aaaatttgct acttaaatcg tacttctctg aagaaggaat cggatataac atcatccggg      600

tacccatggc cagctgtgac ttctccatcc gcacctacac ctatgcagac acccctgatg      660

atttccagtt gcacaacttc agcctcccag aggaagatac caagctcaag atacccctga      720

ttcaccgagc cctgcagttg gcccagcgtc ccgtttcact ccttgccagc ccctggacat      780

cacccacttg gctcaagacc aatggagcgg tgaatgggaa ggggtcactc aagggacagc      840

ccggagacat ctaccaccag acctgggcca gatactttgt gaagttcctg gatgcctatg      900

ctgagcacaa gttacagttc tgggcagtga cagctgaaaa tgagccttct gctgggctgt      960

tgagtggata ccccttccag tgcctgggct tcacccctga acatcagcga gacttcattg     1020

cccgtgacct aggtcctacc ctcgccaaca gtactcacca caatgtccgc ctactcatgc     1080

tggatgacca acgcttgctg ctgccccact gggcaaaggt ggtactgaca gacccagaag     1140

cagctaaata tgttcatggc attgctgtac attggtacct ggactttctg gctccagcca     1200

aagccaccct aggggagaca caccgcctgt tccccaacac catgctcttt gcctcagagg     1260

cctgtgtggg ctccaagttc tgggagcaga gtgtgcggct aggctcctgg gatcgaggga     1320

tgcagtacag ccacagcatc atcacgaacc tcctgtacca tgtggtcggc tggaccgact     1380

ggaaccttgc cctgaacccc gaaggaggac ccaattgggt gcgtaacttt gtcgacagtc     1440

ccatcattgt agacatcacc aaggacacgt tttacaaaca gcccatgttc taccaccttg     1500

gccacttcag caagttcatt cctgagggct cccagagagt ggggctggtt gccagtcaga     1560

agaacgacct ggacgcagtg gcactgatgc atcccgatgg ctctgctgtt gtggtcgtgc     1620

taaaccgctc ctctaaggat gtgcctctta ccatcaagga tcctgctgtg ggcttcctgg     1680

agacaatctc acctggctac tccattcaca cctacctgtg gcatcgccag tgatggagca     1740

gatactcaag gaggcactgg gctcagcctg ggcattaaag ggacagagtc agctcacacg     1800

ctgtctgtga ctaaagaggg cacagcaggg ccagtgtgag cttacagcga cgtaagccca     1860

ggggcaatgg tttgggtgac tcactttccc ctctaggtgg tgcccagggc tggaggcccc     1920

tagaaaaaga tcagtaagcc ccagtgtccc cccagccccc atgcttatgt gaacatgcgc     1980

tgtgtgctgc ttgctttgga aactngcctg ggtccaggcc tagggtgagc tcactgtccg     2040

tacaaacaca agatcagggc tgagggtaag gaaaagaaga gactaggaaa gctgggccca     2100

aaactggaga ctgtttgtct ttcctagaga tgcagaactg ggcccgtgga gcagcagtgt     2160

cagcatcagg gcggaagcct taaagcagca gcgggtgtgc ccaggcaccc agatgattcc     2220

tatggcacca gccaggaaaa atggcagctc ttaaaggaga aaatgtttga gccca          2275


<210>  7
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7
atggaattca gcagccccag ccgggaggaa tgccccaagc ccctgagcag agtgtccatc       60

atggccggat ctctgaccgg actgctgctg ctgcaagccg tgtcttgggc cagcggcgcc      120

agaccttgca tccccaagag cttcggctac agcagcgtcg tgtgcgtgtg caacgccacc      180

tactgcgaca gcttcgaccc ccctaccttt cccgccctgg gcaccttcag cagatacgag      240

agcacccgca gcggcagacg gatggaactg agcatgggcc ccatccaggc caatcacacc      300

ggaaccggcc tgctgctgac cctgcagccc gagcagaaat tccagaaagt gaagggcttc      360

ggcggagcca tgacagacgc cgctgccctg aacatcctgg ccctgagccc ccctgctcag      420

aatctgctgc tcaagagcta cttcagcgag gaaggcatcg gctacaacat catccgggtg      480

cccatggcta gctgcgactt cagcatccgg acctacacct acgccgacac ccccgacgac      540

ttccagctgc acaacttcag cctgcccgaa gaggacacca agctgaagat ccccctgatc      600

cacagagccc tgcagctggc ccagaggcct gtgtctctgc tggctagccc ttggaccagc      660

cccacctggc tgaaaaccaa cggagccgtg aacggcaagg gcagcctgaa gggccagccc      720

ggcgacatct accaccagac ctgggcccgg tacttcgtga agttcctgga cgcctatgcc      780

gagcacaagc tgcagttctg ggccgtgacc gccgagaatg agcctagcgc tggactgctg      840

tccggctacc ccttccaatg cctgggcttc acacccgagc accagcggga ctttatcgcc      900

agagatctgg gccccacact ggccaacagc acccaccaca acgtgcggct gctgatgctg      960

gacgaccaga gactgctgct cccccactgg gccaaggtgg tgctgacaga ccccgaggcc     1020

gccaaatacg tccacgggat tgccgtgcac tggtatctgg actttctggc ccctgccaag     1080

gccacactgg gcgagacaca ccggctgttc cccaacacca tgctgttcgc cagcgaggcc     1140

tgcgtgggca gcaagttctg ggagcagagc gtgcggctgg gcagctggga cagaggcatg     1200

cagtacagcc acagcatcat caccaacctg ctgtaccacg tcgtgggctg gaccgactgg     1260

aatctggccc tgaaccctga gggaggaccc aactgggtcc gcaacttcgt ggacagcccc     1320

atcatcgtgg acatcaccaa ggacaccttc tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc cgagggcagc cagagagtgg gactggtcgc cagccagaag     1440

aacgatctgg acgccgtggc cctgatgcac cctgatggca gcgctgtggt ggtggtcctg     1500

aatcggtcca gcaaggacgt gcccctgacc atcaaggacc ccgccgtggg cttcctggaa     1560

accatcagcc ccggctactc catccacacc tacctgtggc ggagacaatg a              1611


<210>  8
<211>  1869
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8
atggaattca gcagccccag ccgggaggaa tgccccaagc ccctgagcag agtgtccatc       60

atggccggat ctctgaccgg actgctgctg ctgcaagccg tgtcttgggc cagcggcgcc      120

agaccttgca tccccaagag cttcggctac agcagcgtcg tgtgcgtgtg caacgccacc      180

tactgcgaca gcttcgaccc ccctaccttt cccgccctgg gcaccttcag cagatacgag      240

agcacccgca gcggcagacg gatggaactg agcatgggcc ccatccaggc caatcacacc      300

ggaaccggcc tgctgctgac cctgcagccc gagcagaaat tccagaaagt gaagggcttc      360

ggcggagcca tgacagacgc cgctgccctg aacatcctgg ccctgagccc ccctgctcag      420

aatctgctgc tcaagagcta cttcagcgag gaaggcatcg gctacaacat catccgggtg      480

cccatggcta gctgcgactt cagcatccgg acctacacct acgccgacac ccccgacgac      540

ttccagctgc acaacttcag cctgcccgaa gaggacacca agctgaagat ccccctgatc      600

cacagagccc tgcagctggc ccagaggcct gtgtctctgc tggctagccc ttggaccagc      660

cccacctggc tgaaaaccaa cggagccgtg aacggcaagg gcagcctgaa gggccagccc      720

ggcgacatct accaccagac ctgggcccgg tacttcgtga agttcctgga cgcctatgcc      780

gagcacaagc tgcagttctg ggccgtgacc gccgagaatg agcctagcgc tggactgctg      840

tccggctacc ccttccaatg cctgggcttc acacccgagc accagcggga ctttatcgcc      900

agagatctgg gccccacact ggccaacagc acccaccaca acgtgcggct gctgatgctg      960

gacgaccaga gactgctgct cccccactgg gccaaggtgg tgctgacaga ccccgaggcc     1020

gccaaatacg tccacgggat tgccgtgcac tggtatctgg actttctggc ccctgccaag     1080

gccacactgg gcgagacaca ccggctgttc cccaacacca tgctgttcgc cagcgaggcc     1140

tgcgtgggca gcaagttctg ggagcagagc gtgcggctgg gcagctggga cagaggcatg     1200

cagtacagcc acagcatcat caccaacctg ctgtaccacg tcgtgggctg gaccgactgg     1260

aatctggccc tgaaccctga gggaggaccc aactgggtcc gcaacttcgt ggacagcccc     1320

atcatcgtgg acatcaccaa ggacaccttc tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc cgagggcagc cagagagtgg gactggtcgc cagccagaag     1440

aacgatctgg acgccgtggc cctgatgcac cctgatggca gcgctgtggt ggtggtcctg     1500

aatcggtcca gcaaggacgt gcccctgacc atcaaggacc ccgccgtggg cttcctggaa     1560

accatcagcc ccggctactc catccacacc tacctgtggc ggagacaagg cggaggcgga     1620

gctggtggcg gcggagcagg cggtggtggt gcaggcggcg gaggtgctgg cggaggacca     1680

tctctttgtg gcggagaact ggtggacacc ctgcagttcg tgtgtggcga cagaggcttc     1740

tactttagca gacccgccag cagagtgtcc gccagatcta gaggaatcgt ggaagagtgc     1800

tgcttcagaa gctgcgacct ggcactgctg gaaacctact gtgccacacc agccaagagc     1860

gagtgatga                                                             1869


<210>  9
<211>  1887
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9
atggaattca gcagccccag ccgggaggaa tgccccaagc ccctgagcag agtgtccatc       60

atggccggat ctctgaccgg actgctgctg ctgcaagccg tgtcttgggc cagcggcgcc      120

agaccttgca tccccaagag cttcggctac agcagcgtcg tgtgcgtgtg caacgccacc      180

tactgcgaca gcttcgaccc ccctaccttt cccgccctgg gcaccttcag cagatacgag      240

agcacccgca gcggcagacg gatggaactg agcatgggcc ccatccaggc caatcacacc      300

ggaaccggcc tgctgctgac cctgcagccc gagcagaaat tccagaaagt gaagggcttc      360

ggcggagcca tgacagacgc cgctgccctg aacatcctgg ccctgagccc ccctgctcag      420

aatctgctgc tcaagagcta cttcagcgag gaaggcatcg gctacaacat catccgggtg      480

cccatggcta gctgcgactt cagcatccgg acctacacct acgccgacac ccccgacgac      540

ttccagctgc acaacttcag cctgcccgaa gaggacacca agctgaagat ccccctgatc      600

cacagagccc tgcagctggc ccagaggcct gtgtctctgc tggctagccc ttggaccagc      660

cccacctggc tgaaaaccaa cggagccgtg aacggcaagg gcagcctgaa gggccagccc      720

ggcgacatct accaccagac ctgggcccgg tacttcgtga agttcctgga cgcctatgcc      780

gagcacaagc tgcagttctg ggccgtgacc gccgagaatg agcctagcgc tggactgctg      840

tccggctacc ccttccaatg cctgggcttc acacccgagc accagcggga ctttatcgcc      900

agagatctgg gccccacact ggccaacagc acccaccaca acgtgcggct gctgatgctg      960

gacgaccaga gactgctgct cccccactgg gccaaggtgg tgctgacaga ccccgaggcc     1020

gccaaatacg tccacgggat tgccgtgcac tggtatctgg actttctggc ccctgccaag     1080

gccacactgg gcgagacaca ccggctgttc cccaacacca tgctgttcgc cagcgaggcc     1140

tgcgtgggca gcaagttctg ggagcagagc gtgcggctgg gcagctggga cagaggcatg     1200

cagtacagcc acagcatcat caccaacctg ctgtaccacg tcgtgggctg gaccgactgg     1260

aatctggccc tgaaccctga gggaggaccc aactgggtcc gcaacttcgt ggacagcccc     1320

atcatcgtgg acatcaccaa ggacaccttc tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc cgagggcagc cagagagtgg gactggtcgc cagccagaag     1440

aacgatctgg acgccgtggc cctgatgcac cctgatggca gcgctgtggt ggtggtcctg     1500

aatcggtcca gcaaggacgt gcccctgacc atcaaggacc ccgccgtggg cttcctggaa     1560

accatcagcc ccggctactc catccacacc tacctgtggc ggagacaagg agcaccaggc     1620

ggaggatctc cagctcctgc tcctacacca gctccagcac cgacgcctgc tccagctggc     1680

ggaggacctt ctggtgcacc tctttgtggc ggagagctgg tggataccct gcagttcgtg     1740

tgtggcgacc ggggcttcta ctttagcaga cctgccagca gagtgtccgc cagatctaga     1800

ggcatcgtgg aagagtgctg cttcagaagc tgcgacctgg cactgctgga aacctactgt     1860

gccacaccag ccaagagcga gtgatga                                         1887


<210>  10
<211>  1962
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10
atggaattca gcagccccag ccgggaggaa tgccccaagc ccctgagcag agtgtccatc       60

atggccggat ctctgaccgg actgctgctg ctgcaagccg tgtcttgggc cagcggcgcc      120

agaccttgca tccccaagag cttcggctac agcagcgtcg tgtgcgtgtg caacgccacc      180

tactgcgaca gcttcgaccc ccctaccttt cccgccctgg gcaccttcag cagatacgag      240

agcacccgca gcggcagacg gatggaactg agcatgggcc ccatccaggc caatcacacc      300

ggaaccggcc tgctgctgac cctgcagccc gagcagaaat tccagaaagt gaagggcttc      360

ggcggagcca tgacagacgc cgctgccctg aacatcctgg ccctgagccc ccctgctcag      420

aatctgctgc tcaagagcta cttcagcgag gaaggcatcg gctacaacat catccgggtg      480

cccatggcta gctgcgactt cagcatccgg acctacacct acgccgacac ccccgacgac      540

ttccagctgc acaacttcag cctgcccgaa gaggacacca agctgaagat ccccctgatc      600

cacagagccc tgcagctggc ccagaggcct gtgtctctgc tggctagccc ttggaccagc      660

cccacctggc tgaaaaccaa cggagccgtg aacggcaagg gcagcctgaa gggccagccc      720

ggcgacatct accaccagac ctgggcccgg tacttcgtga agttcctgga cgcctatgcc      780

gagcacaagc tgcagttctg ggccgtgacc gccgagaatg agcctagcgc tggactgctg      840

tccggctacc ccttccaatg cctgggcttc acacccgagc accagcggga ctttatcgcc      900

agagatctgg gccccacact ggccaacagc acccaccaca acgtgcggct gctgatgctg      960

gacgaccaga gactgctgct cccccactgg gccaaggtgg tgctgacaga ccccgaggcc     1020

gccaaatacg tccacgggat tgccgtgcac tggtatctgg actttctggc ccctgccaag     1080

gccacactgg gcgagacaca ccggctgttc cccaacacca tgctgttcgc cagcgaggcc     1140

tgcgtgggca gcaagttctg ggagcagagc gtgcggctgg gcagctggga cagaggcatg     1200

cagtacagcc acagcatcat caccaacctg ctgtaccacg tcgtgggctg gaccgactgg     1260

aatctggccc tgaaccctga gggaggaccc aactgggtcc gcaacttcgt ggacagcccc     1320

atcatcgtgg acatcaccaa ggacaccttc tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc cgagggcagc cagagagtgg gactggtcgc cagccagaag     1440

aacgatctgg acgccgtggc cctgatgcac cctgatggca gcgctgtggt ggtggtcctg     1500

aatcggtcca gcaaggacgt gcccctgacc atcaaggacc ccgccgtggg cttcctggaa     1560

accatcagcc ccggctactc catccacacc tacctgtggc ggagacaagg agcaccaggc     1620

ggatctccag caggatctcc aacctctacc gaggaaggca caagcgagtc tgccacacct     1680

gagtctggac ctggcacaag cacagagcct agcgaaggat ctgccccagg ttctcctgcc     1740

ggctctccta caagtacagg accttctggc gctccactgt gtggcggaga actggtggat     1800

accctgcagt tcgtgtgcgg cgacagaggc ttctacttta gcagacccgc cagcagagtg     1860

tccgccagat ctagaggaat cgtggaagag tgctgcttca gaagctgcga tctggcactg     1920

ctggaaacct actgtgccac accagccaag agcgagtgat ga                        1962


<210>  11
<211>  1566
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11
atggggattc ctatgggcaa gtctatgctg gtcctgctga catttctggc cttcgcttca       60

tgctgtatcg ctgccagacc ttgcatcccc aagagcttcg gctacagcag cgtcgtgtgc      120

gtgtgcaacg ccacctactg cgacagcttc gaccccccta cctttcccgc cctgggcacc      180

ttcagcagat acgagagcac ccgcagcggc agacggatgg aactgagcat gggccccatc      240

caggccaatc acaccggaac cggcctgctg ctgaccctgc agcccgagca gaaattccag      300

aaagtgaagg gcttcggcgg agccatgaca gacgccgctg ccctgaacat cctggccctg      360

agcccccctg ctcagaatct gctgctcaag agctacttca gcgaggaagg catcggctac      420

aacatcatcc gggtgcccat ggctagctgc gacttcagca tccggaccta cacctacgcc      480

gacacccccg acgacttcca gctgcacaac ttcagcctgc ccgaagagga caccaagctg      540

aagatccccc tgatccacag agccctgcag ctggcccaga ggcctgtgtc tctgctggct      600

agcccttgga ccagccccac ctggctgaaa accaacggag ccgtgaacgg caagggcagc      660

ctgaagggcc agcccggcga catctaccac cagacctggg cccggtactt cgtgaagttc      720

ctggacgcct atgccgagca caagctgcag ttctgggccg tgaccgccga gaatgagcct      780

agcgctggac tgctgtccgg ctaccccttc caatgcctgg gcttcacacc cgagcaccag      840

cgggacttta tcgccagaga tctgggcccc acactggcca acagcaccca ccacaacgtg      900

cggctgctga tgctggacga ccagagactg ctgctccccc actgggccaa ggtggtgctg      960

acagaccccg aggccgccaa atacgtccac gggattgccg tgcactggta tctggacttt     1020

ctggcccctg ccaaggccac actgggcgag acacaccggc tgttccccaa caccatgctg     1080

ttcgccagcg aggcctgcgt gggcagcaag ttctgggagc agagcgtgcg gctgggcagc     1140

tgggacagag gcatgcagta cagccacagc atcatcacca acctgctgta ccacgtcgtg     1200

ggctggaccg actggaatct ggccctgaac cctgagggag gacccaactg ggtccgcaac     1260

ttcgtggaca gccccatcat cgtggacatc accaaggaca ccttctacaa gcagcccatg     1320

ttctaccacc tgggccactt cagcaagttc atccccgagg gcagccagag agtgggactg     1380

gtcgccagcc agaagaacga tctggacgcc gtggccctga tgcaccctga tggcagcgct     1440

gtggtggtgg tcctgaatcg gtccagcaag gacgtgcccc tgaccatcaa ggaccccgcc     1500

gtgggcttcc tggaaaccat cagccccggc tactccatcc acacctacct gtggcggaga     1560

caatga                                                                1566


<210>  12
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala 
            20                  


<210>  13
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13
atggggattc ctatgggcaa gtctatgctg gtcctgctga catttctggc cttcgcttca       60

tgctgtatcg ct                                                           72


<210>  14
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Arg Cys Cys Phe Tyr Thr Ala Gly Thr Leu Ser Leu Leu Leu 
1               5                   10                  15      


Leu Val Thr Ser Val Thr Leu Leu Val Ala Arg Val Phe Gln Lys Ala 
            20                  25                  30          


Val Asp Gln Ser Ile Glu Lys Lys Ile Val Leu Arg Asn Gly Thr Glu 
        35                  40                  45              


Ala Phe Asp Ser Trp Glu Lys Pro Pro Leu Pro Val Tyr Thr Gln Phe 
    50                  55                  60                  


Tyr Phe Phe Asn Val Thr Asn Pro Glu Glu Ile Leu Arg Gly Glu Thr 
65                  70                  75                  80  


Pro Arg Val Glu Glu Val Gly Pro Tyr Thr Tyr Arg Glu Leu Arg Asn 
                85                  90                  95      


Lys Ala Asn Ile Gln Phe Gly Asp Asn Gly Thr Thr Ile Ser Ala Val 
            100                 105                 110         


Ser Asn Lys Ala Tyr Val Phe Glu Arg Asp Gln Ser Val Gly Asp Pro 
        115                 120                 125             


Lys Ile Asp Leu Ile Arg Thr Leu Asn Ile Pro Val Leu Thr Val Ile 
    130                 135                 140                 


Glu Trp Ser Gln Val His Phe Leu Arg Glu Ile Ile Glu Ala Met Leu 
145                 150                 155                 160 


Lys Ala Tyr Gln Gln Lys Leu Phe Val Thr His Thr Val Asp Glu Leu 
                165                 170                 175     


Leu Trp Gly Tyr Lys Asp Glu Ile Leu Ser Leu Ile His Val Phe Arg 
            180                 185                 190         


Pro Asp Ile Ser Pro Tyr Phe Gly Leu Phe Tyr Glu Lys Asn Gly Thr 
        195                 200                 205             


Asn Asp Gly Asp Tyr Val Phe Leu Thr Gly Glu Asp Ser Tyr Leu Asn 
    210                 215                 220                 


Phe Thr Lys Ile Val Glu Trp Asn Gly Lys Thr Ser Leu Asp Trp Trp 
225                 230                 235                 240 


Ile Thr Asp Lys Cys Asn Met Ile Asn Gly Thr Asp Gly Asp Ser Phe 
                245                 250                 255     


His Pro Leu Ile Thr Lys Asp Glu Val Leu Tyr Val Phe Pro Ser Asp 
            260                 265                 270         


Phe Cys Arg Ser Val Tyr Ile Thr Phe Ser Asp Tyr Glu Ser Val Gln 
        275                 280                 285             


Gly Leu Pro Ala Phe Arg Tyr Lys Val Pro Ala Glu Leu Ala Asn Thr 
    290                 295                 300                 


Ser Asp Asn Ala Gly Phe Cys Ile Pro Glu Gly Asn Cys Leu Gly Ser 
305                 310                 315                 320 


Gly Val Leu Asn Val Ser Ile Cys Lys Asn Gly Ala Pro Ile Ile Met 
                325                 330                 335     


Ser Phe Pro His Phe Tyr Gln Ala Asp Glu Arg Phe Val Ser Ala Ile 
            340                 345                 350         


Glu Gly Met His Pro Asn Gln Glu Asp His Glu Thr Phe Val Asp Ile 
        355                 360                 365             


Asn Pro Leu Thr Gly Ile Ile Leu Lys Ala Ala Lys Arg Phe Gln Ile 
    370                 375                 380                 


Asn Ile Tyr Val Lys Lys Leu Asp Asp Phe Val Glu Thr Gly Asp Ile 
385                 390                 395                 400 


Arg Thr Met Val Phe Pro Val Met Tyr Leu Asn Glu Ser Val His Ile 
                405                 410                 415     


Asp Lys Glu Thr Ala Ser Arg Leu Lys Ser Met Ile Asn Thr Thr Leu 
            420                 425                 430         


Ile Ile Thr Asn Ile Pro Tyr Ile Ile Met Ala Leu Gly Val Phe Phe 
        435                 440                 445             


Gly Leu Val Phe Thr Trp Leu Ala Cys Lys Gly Gln Gly Ser Met Asp 
    450                 455                 460                 


Glu Gly Thr Ala Asp Glu Arg Ala Pro Leu Ile Arg Thr 
465                 470                 475         


<210>  15
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gly Arg Cys Cys Phe Tyr Thr Ala Gly Thr Leu Ser Leu Leu Leu 
1               5                   10                  15      


Leu Val Thr Ser Val Thr Leu Leu Val Ala Arg Val Phe Gln Lys Ala 
            20                  25                  30          


Val Asp Gln Ser Ile Glu Lys Lys Ile Val Leu Arg Asn Gly Thr Glu 
        35                  40                  45              


Ala Phe Asp Ser Trp Glu Lys Pro Pro Leu Pro Val Tyr Thr Gln Phe 
    50                  55                  60                  


Tyr Phe Phe Asn Val Thr Asn Pro Glu Glu Ile Leu Arg Gly Glu Thr 
65                  70                  75                  80  


Pro Arg Val Glu Glu Val Gly Pro Tyr Thr Tyr Arg Ser Leu Asp Trp 
                85                  90                  95      


Trp Ile Thr Asp Lys Cys Asn Met Ile Asn Gly Thr Asp Gly Asp Ser 
            100                 105                 110         


Phe His Pro Leu Ile Thr Lys Asp Glu Val Leu Tyr Val Phe Pro Ser 
        115                 120                 125             


Asp Phe Cys Arg Ser Val Tyr Ile Thr Phe Ser Asp Tyr Glu Ser Val 
    130                 135                 140                 


Gln Gly Leu Pro Ala Phe Arg Tyr Lys Val Pro Ala Glu Ile Leu Ala 
145                 150                 155                 160 


Asn Thr Ser Asp Asn Ala Gly Phe Cys Ile Pro Glu Gly Asn Cys Leu 
                165                 170                 175     


Gly Ser Gly Val Leu Asn Val Ser Ile Cys Lys Asn Gly Ala Pro Ile 
            180                 185                 190         


Ile Met Ser Phe Pro His Phe Tyr Gln Ala Asp Glu Arg Phe Val Ser 
        195                 200                 205             


Ala Ile Glu Gly Met His Pro Asn Gln Glu Asp His Glu Thr Phe Val 
    210                 215                 220                 


Asp Ile Asn Pro Leu Thr Gly Ile Ile Leu Lys Ala Ala Lys Arg Phe 
225                 230                 235                 240 


Gln Ile Asn Ile Tyr Val Lys Lys Leu Asp Asp Phe Val Glu Thr Gly 
                245                 250                 255     


Asp Ile Arg Thr Met Val Phe Pro Val Met Tyr Leu Asn Glu Ser Val 
            260                 265                 270         


His Ile Asp Lys Glu Thr Ala Ser Arg Leu Lys Ser Met Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Ile Thr Asn Ile Pro Tyr Ile Ile Met Ala Leu Gly Val 
    290                 295                 300                 


Phe Phe Gly Leu Val Phe Thr Trp Leu Ala Cys Lys Gly Gln Gly Ser 
305                 310                 315                 320 


Met Asp Glu Gly Thr Ala Asp Glu Arg Ala Pro Leu Ile Arg Thr 
                325                 330                 335 


<210>  16
<211>  4780
<212>  DNA
<213>  Homo sapiens

<400>  16
gcagtcgccg gcggttgcct cgcggggttg cggcgagccc ggcccgcgaa cgtcacgtcc       60

ctgcgcgctc cctgcactct cccgagctgc gctaggcggg cgccacggct gcccggcgaa      120

ggaaaccgaa accgagtccg ggcccgtccc tccgcggccc catccgcccg gtgcacccgg      180

ggccgcgctc gccaggccgc ggagcccaga gctgcgcgca cgaaccgtgc gccgggaggg      240

cgtgggcgtg gcgccgaagg gtcccgggtc ttcgacgcct ctgcggcggc tcctccctcc      300

ttgcagttgg atccctggcg ggtgcggccc ggcccggccc gtgagcggcg cacagaatgg      360

gccgatgctg cttctacacg gcggggacgt tgtccctgct cctgctggtg accagcgtca      420

cgctgctggt ggcccgggtc ttccagaagg ctgtagacca gagtatcgag aagaaaattg      480

tgttaaggaa tggtactgag gcatttgact cctgggagaa gccccctctg cctgtgtata      540

ctcagttcta tttcttcaat gtcaccaatc cagaggagat cctcagaggg gagacccctc      600

gggtggaaga agtggggcca tacacctaca gggaactcag aaacaaagca aatattcaat      660

ttggagataa tggaacaaca atatctgctg ttagcaacaa ggcctatgtt tttgaacgag      720

accaatctgt tggagaccct aaaattgact taattagaac attaaatatt cctgtattga      780

ctgtcataga gtggtcccag gtgcacttcc tcagggagat catcgaggcc atgttgaaag      840

cctatcagca gaagctcttt gtgactcaca cagttgacga attgctctgg ggctacaaag      900

atgaaatctt gtcccttatc catgttttca ggcccgatat ctctccctat tttggcctat      960

tctatgagaa aaatgggact aatgatggag actatgtttt tctaactgga gaagacagtt     1020

accttaactt tacaaaaatt gtggaatgga atgggaaaac gtcacttgac tggtggataa     1080

cagacaagtg caatatgatt aatggaacag atggagattc ttttcaccca ctaataacca     1140

aagatgaggt cctttatgtc ttcccatctg acttttgcag gtcagtgtat attactttca     1200

gtgactatga gagtgtacag ggactgcctg cctttcggta taaagttcct gcagaaatat     1260

tagccaatac gtcagacaat gccggcttct gtatacctga gggaaactgc ctgggctcag     1320

gagttctgaa tgtcagcatc tgcaagaatg gtgcacccat cattatgtct ttcccacact     1380

tttaccaagc agatgagagg tttgtttctg ccatagaagg catgcaccca aatcaggaag     1440

accatgagac atttgtggac attaatcctt tgactggaat aatcctaaaa gcagccaaga     1500

ggttccaaat caacatttat gtcaaaaaat tagatgactt tgttgaaacg ggagacatta     1560

gaaccatggt tttcccagtg atgtacctca atgagagtgt tcacattgat aaagagacgg     1620

cgagtcgact gaagtctatg attaacacta ctttgatcat caccaacata ccctacatca     1680

tcatggcgct gggtgtgttc tttggtttgg tttttacctg gcttgcatgc aaaggacagg     1740

gatccatgga tgagggaaca gcggatgaaa gagcacccct cattcgaacc taaacattgc     1800

ctttgcttgg tgaagaaact gtgtgagctg tcctgacctg gacgatgacg tggggaaacc     1860

ctccacctcc ttgcaggctt gttgcctgtt gaaagaagga aaaagacacg gcgctggcaa     1920

gtgataggaa cattctggcc agaggttaaa gagcaggctg acatggctgg ccattaagct     1980

ttataaaatc atgtgggctc tgaaattgtt cttttatgtg tctagcaagt atttaataaa     2040

cccttgtata gtaattttgt tgttgttggg tgctggtagc tccagaattt tgtgaccact     2100

attgtgggta aaatgtctct gcatcacttg ttaatgctac tggtctaact tcattcagta     2160

tgcttcattc accgaacttt gtgctcaaaa tgcgtatata ccattttatg ttgtattcct     2220

ccatttcact tgcaaaacag aagtaaataa gagttcggga cccagggtaa aatggtagct     2280

tcatccaata tatcattcaa atgcatctga tttctaaaac atattacatt ttatgctgat     2340

cttcagttca taattcttcc aggaaaactc agtcttccaa ctgcaataaa atactgggta     2400

gaatcaaatg ggaaaggggt tgggtggggc aatacccatg agttgatagt gataagctcc     2460

taaggatttt taacttgtac ttttgtgaac gaagagaatg cataaataat gttggtgagg     2520

ataaagtaca gatatttcat gtagaattaa ttgctagtta tgatgcttgt ggatagttaa     2580

ctgttttttt tttagtcaaa atgatcatgc tacgaaaaga tgcttctgag agaatgtaat     2640

gagtaactga tttttcttcc tgagtcgccc ttgccaaata tgttactgta ttaattaatc     2700

taatattgag tgattatttg taaaattatg aatatgggaa atccatctat ctacagccta     2760

agttacacat aagtttcaga aagtctgatt agactaaaga gatatttctt ctgggacagc     2820

cgccttcttg gtaattttga agttcttttt acaagttcct tcctcagttt cagttctttc     2880

cagtgttttg tagctcactg tcactcactg aatagagaaa cgtgtgccct atacttcctg     2940

tgacaatcat tttgctgaca gaatgatgga tgtttaaaat attgcacaaa gtactttaaa     3000

gaaaggtctg ttaggaccag aagcagagac accacttttc aaaggacttc ttggtttcag     3060

cataacctaa gacagggaat tgggagccat catatgtcac agtgttcaga attcaagcat     3120

atttaagggc attttctttg attctcaaag ttcagcattc attttgaatt gagaagccta     3180

tacatttagc tgacaaagtg cttatagaat ttcttaacaa ctgaaccatt caaaaggatt     3240

ttttttgttt aaaactggat ttcaatgtaa gcaaatgaag aaaaaaatat agatttcatt     3300

tccatagctt cttatccctg tattgaggta ataaattgtt ttactgacaa tttttccttt     3360

ttctacacta aaacaatatg tgatatattt cccctcttga agaggcaatt cattaaactc     3420

tcaaattttc tatagaatca agatagaacc tttagatact ccaactcacc aaaatgtaaa     3480

aaaactaaca aaaatatttg gtcttcaata atgctaaata tctacatttt tagaatttat     3540

caacatttaa ctagataatt gggcatgtct taattatgca tgtacttatc catactaata     3600

aaattgacaa tgctagtgca tacttattgg tttagtccta ttatcaggat ataatcatct     3660

gtgaggagga tattttaaat actgtaaatg ataacagtta atgatataca catttagact     3720

gagttgcaca ctggcaggga gaccaaaaac attacttcca tacttgtgtc atgattcttt     3780

tttttttgag agagtctcac tctgtcgcca ggctggagta cagtggcatg atctcggctc     3840

actgcaacct ctgcctcccg ggttcaagca attctcctgc ctcagccacc caagtagctg     3900

ggactacagg tgcgtgccac cacgcccagc taaattttgt atttttagtg gagacggggt     3960

ttcaccatgt tggccaggat ggtctcaatc tcctgaccct gcgatctgcc cacctcagcc     4020

tcccaaagtg ctgggattac aggcgtaagc caccgggcct ggcctgtttt atgattctta     4080

atagttactt ggtttaaatc acatttgata ctatccttct gaaaagtctg agacagatct     4140

acaaactaca gtcaaaatta tagattaaga ggaatgaatg cacctatttg gctttaagtt     4200

gaagatgaat tatttctcat gctcattttc ttgcggcagt tatcttagaa agacccccaa     4260

aggctttgtg attgtaagca ctgtcatgat cacagaatgc aagcttctgg taccatgatc     4320

ctcaacttag agaggaagaa accaagacag agagcttaac tcacttctct cagggaaaat     4380

taggagttga gcacaggaca ggaaatgggc tttgccactt ttagctccag gcttttctaa     4440

ccagacttga tttcctcatg ttctagaaag atcactaatg gtcaagtgga acaagcacta     4500

cacgactaac ccctattggg gtttttaact taagggaggc taatttttaa tttaaactgc     4560

tcgagatatg agttctgcaa aaggtggtcc gcatccttgg ccctctggac attatcacta     4620

aattgcttgt gcctgttaac aagaatactg accagaatgc tcttcatgta gcttatacag     4680

ttggttcact tcatgcggtt cttgacatgt ttatttctac ccttaatgca atgaaatgtt     4740

tcattaataa aaaaccactt tatataaaaa aaaaaaaaaa                           4780


<210>  17
<211>  4340
<212>  DNA
<213>  Homo sapiens

<400>  17
gcagtcgccg gcggttgcct cgcggggttg cggcgagccc ggcccgcgaa cgtcacgtcc       60

ctgcgcgctc cctgcactct cccgagctgc gctaggcggg cgccacggct gcccggcgaa      120

ggaaaccgaa accgagtccg ggcccgtccc tccgcggccc catccgcccg gtgcacccgg      180

ggccgcgctc gccaggccgc ggagcccaga gctgcgcgca cgaaccgtgc gccgggaggg      240

cgtgggcgtg gcgccgaagg gtcccgggtc ttcgacgcct ctgcggcggc tcctccctcc      300

ttgcagttgg atccctggcg ggtgcggccc ggcccggccc gtgagcggcg cacagaatgg      360

gccgatgctg cttctacacg gcggggacgt tgtccctgct cctgctggtg accagcgtca      420

cgctgctggt ggcccgggtc ttccagaagg ctgtagacca gagtatcgag aagaaaattg      480

tgttaaggaa tggtactgag gcatttgact cctgggagaa gccccctctg cctgtgtata      540

ctcagttcta tttcttcaat gtcaccaatc cagaggagat cctcagaggg gagacccctc      600

gggtggaaga agtggggcca tacacctaca ggtcacttga ctggtggata acagacaagt      660

gcaatatgat taatggaaca gatggagatt cttttcaccc actaataacc aaagatgagg      720

tcctttatgt cttcccatct gacttttgca ggtcagtgta tattactttc agtgactatg      780

agagtgtaca gggactgcct gcctttcggt ataaagttcc tgcagaaata ttagccaata      840

cgtcagacaa tgccggcttc tgtatacctg agggaaactg cctgggctca ggagttctga      900

atgtcagcat ctgcaagaat ggtgcaccca tcattatgtc tttcccacac ttttaccaag      960

cagatgagag gtttgtttct gccatagaag gcatgcaccc aaatcaggaa gaccatgaga     1020

catttgtgga cattaatcct ttgactggaa taatcctaaa agcagccaag aggttccaaa     1080

tcaacattta tgtcaaaaaa ttagatgact ttgttgaaac gggagacatt agaaccatgg     1140

ttttcccagt gatgtacctc aatgagagtg ttcacattga taaagagacg gcgagtcgac     1200

tgaagtctat gattaacact actttgatca tcaccaacat accctacatc atcatggcgc     1260

tgggtgtgtt ctttggtttg gtttttacct ggcttgcatg caaaggacag ggatccatgg     1320

atgagggaac agcggatgaa agagcacccc tcattcgaac ctaaacattg cctttgcttg     1380

gtgaagaaac tgtgtgagct gtcctgacct ggacgatgac gtggggaaac cctccacctc     1440

cttgcaggct tgttgcctgt tgaaagaagg aaaaagacac ggcgctggca agtgatagga     1500

acattctggc cagaggttaa agagcaggct gacatggctg gccattaagc tttataaaat     1560

catgtgggct ctgaaattgt tcttttatgt gtctagcaag tatttaataa acccttgtat     1620

agtaattttg ttgttgttgg gtgctggtag ctccagaatt ttgtgaccac tattgtgggt     1680

aaaatgtctc tgcatcactt gttaatgcta ctggtctaac ttcattcagt atgcttcatt     1740

caccgaactt tgtgctcaaa atgcgtatat accattttat gttgtattcc tccatttcac     1800

ttgcaaaaca gaagtaaata agagttcggg acccagggta aaatggtagc ttcatccaat     1860

atatcattca aatgcatctg atttctaaaa catattacat tttatgctga tcttcagttc     1920

ataattcttc caggaaaact cagtcttcca actgcaataa aatactgggt agaatcaaat     1980

gggaaagggg ttgggtgggg caatacccat gagttgatag tgataagctc ctaaggattt     2040

ttaacttgta cttttgtgaa cgaagagaat gcataaataa tgttggtgag gataaagtac     2100

agatatttca tgtagaatta attgctagtt atgatgcttg tggatagtta actgtttttt     2160

ttttagtcaa aatgatcatg ctacgaaaag atgcttctga gagaatgtaa tgagtaactg     2220

atttttcttc ctgagtcgcc cttgccaaat atgttactgt attaattaat ctaatattga     2280

gtgattattt gtaaaattat gaatatggga aatccatcta tctacagcct aagttacaca     2340

taagtttcag aaagtctgat tagactaaag agatatttct tctgggacag ccgccttctt     2400

ggtaattttg aagttctttt tacaagttcc ttcctcagtt tcagttcttt ccagtgtttt     2460

gtagctcact gtcactcact gaatagagaa acgtgtgccc tatacttcct gtgacaatca     2520

ttttgctgac agaatgatgg atgtttaaaa tattgcacaa agtactttaa agaaaggtct     2580

gttaggacca gaagcagaga caccactttt caaaggactt cttggtttca gcataaccta     2640

agacagggaa ttgggagcca tcatatgtca cagtgttcag aattcaagca tatttaaggg     2700

cattttcttt gattctcaaa gttcagcatt cattttgaat tgagaagcct atacatttag     2760

ctgacaaagt gcttatagaa tttcttaaca actgaaccat tcaaaaggat tttttttgtt     2820

taaaactgga tttcaatgta agcaaatgaa gaaaaaaata tagatttcat ttccatagct     2880

tcttatccct gtattgaggt aataaattgt tttactgaca atttttcctt tttctacact     2940

aaaacaatat gtgatatatt tcccctcttg aagaggcaat tcattaaact ctcaaatttt     3000

ctatagaatc aagatagaac ctttagatac tccaactcac caaaatgtaa aaaaactaac     3060

aaaaatattt ggtcttcaat aatgctaaat atctacattt ttagaattta tcaacattta     3120

actagataat tgggcatgtc ttaattatgc atgtacttat ccatactaat aaaattgaca     3180

atgctagtgc atacttattg gtttagtcct attatcagga tataatcatc tgtgaggagg     3240

atattttaaa tactgtaaat gataacagtt aatgatatac acatttagac tgagttgcac     3300

actggcaggg agaccaaaaa cattacttcc atacttgtgt catgattctt ttttttttga     3360

gagagtctca ctctgtcgcc aggctggagt acagtggcat gatctcggct cactgcaacc     3420

tctgcctccc gggttcaagc aattctcctg cctcagccac ccaagtagct gggactacag     3480

gtgcgtgcca ccacgcccag ctaaattttg tatttttagt ggagacgggg tttcaccatg     3540

ttggccagga tggtctcaat ctcctgaccc tgcgatctgc ccacctcagc ctcccaaagt     3600

gctgggatta caggcgtaag ccaccgggcc tggcctgttt tatgattctt aatagttact     3660

tggtttaaat cacatttgat actatccttc tgaaaagtct gagacagatc tacaaactac     3720

agtcaaaatt atagattaag aggaatgaat gcacctattt ggctttaagt tgaagatgaa     3780

ttatttctca tgctcatttt cttgcggcag ttatcttaga aagaccccca aaggctttgt     3840

gattgtaagc actgtcatga tcacagaatg caagcttctg gtaccatgat cctcaactta     3900

gagaggaaga aaccaagaca gagagcttaa ctcacttctc tcagggaaaa ttaggagttg     3960

agcacaggac aggaaatggg ctttgccact tttagctcca ggcttttcta accagacttg     4020

atttcctcat gttctagaaa gatcactaat ggtcaagtgg aacaagcact acacgactaa     4080

cccctattgg ggtttttaac ttaagggagg ctaattttta atttaaactg ctcgagatat     4140

gagttctgca aaaggtggtc cgcatccttg gccctctgga cattatcact aaattgcttg     4200

tgcctgttaa caagaatact gaccagaatg ctcttcatgt agcttataca gttggttcac     4260

ttcatgcggt tcttgacatg tttatttcta cccttaatgc aatgaaatgt ttcattaata     4320

aaaaaccact ttatataaaa                                                 4340


<210>  18
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  18

Leu Arg Glu Ile Ile Glu Ala Met Leu Lys Ala Tyr Gln Gln Lys Leu 
1               5                   10                  15      


<210>  19
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  19

Ile Ile Glu Ala Met Leu Lys Ala Tyr Gln Gln Lys Leu Phe Val Thr 
1               5                   10                  15      


His Thr Val Asp Glu Leu Leu Trp Gly Tyr Lys Asp Glu Ile Leu Ser 
            20                  25                  30          


Leu Ile His Val Phe 
        35          


<210>  20
<211>  385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20
gatcaaggtt aggaacagag agacaggaga atatgggcca aacaggatat ctgtggtaag       60

cagttcctgc cccggctcag ggccaagaac agttggaaca gcagaatatg ggccaaacag      120

gatatctgtg gtaagcagtt cctgccccgg ctcagggcca agaacagatg gtccccagat      180

gcggtcccgc cctcagcagt ttctagagaa ccatcagatg tttccagggt gccccaagga      240

cctgaaatga ccctgtgcct tatttgaact aaccaatcag ttcgcttctc gcttctgttc      300

gcgcgcttct gctccccgag ctcaataaaa gagcccacaa cccctcactc ggcgcgccag      360

tcctccgata gactgcgtcg cccgg                                            385


<210>  21
<211>  398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21
ttatttagtc tccagaaaaa ggggggaatg aaagacccca cctgtaggtt tggcaagcta       60

ggatcaaggt taggaacaga gagacagcag aatatgggcc aaacaggata tctgtggtaa      120

gcagttcctg ccccggctca gggccaagaa cagttggaac agcagaatat gggccaaaca      180

ggatatctgt ggtaagcagt tcctgccccg gctcagggcc aagaacagat ggtccccaga      240

tgcggtcccg ccctcagcag tttctagaga accatcagat gtttccaggg tgccccaagg      300

acctgaaatg accctgtgcc ttatttgaac taaccaatca gttcgcttct cgcttctgtt      360

cgcgcgcttc tgctccccga gctcaataaa agagccca                              398


<210>  22
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  23
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly 
1               5                   10                  15      


Gly Gly Gly Ala Gly Gly Gly Pro Ser Leu Cys Gly Gly Glu Leu Val 
            20                  25                  30          


Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg 
        35                  40                  45              


Pro Ala Ser Arg Val Ser Ala Arg Ser Arg Gly Ile Val Glu Glu Cys 
    50                  55                  60                  


Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr 
65                  70                  75                  80  


Pro Ala Lys Ser Glu 
                85  


<210>  24
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Gly Ala Pro Gly Gly Gly Ser Pro Ala Pro Ala Pro Thr Pro Ala Pro 
1               5                   10                  15      


Ala Pro Thr Pro Ala Pro Ala Gly Gly Gly Pro Ser Gly Ala Pro Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Ala Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu 
                85                  90      


<210>  25
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Gly Ala Pro Gly Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
1               5                   10                  15      


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 
            20                  25                  30          


Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 
        35                  40                  45              


Ser Thr Gly Pro Ser Gly Ala Pro Leu Cys Gly Gly Glu Leu Val Asp 
    50                  55                  60                  


Thr Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro 
65                  70                  75                  80  


Ala Ser Arg Val Ser Ala Arg Ser Arg Gly Ile Val Glu Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro 
            100                 105                 110         


Ala Lys Ser Glu 
        115     


<210>  26
<211>  260
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26
ggcggaggcg gagctggtgg cggcggagca ggcggtggtg gtgcaggcgg cggaggtgct       60

ggcggaggac catctctttg tggcggagaa ctggtggaca ccctgcagtt cgtgtgtggc      120

gacagaggct tctactttag cagacccgcc agcagagtgt ccgccagatc tagaggaatc      180

gtggaagagt gctgcttcag aagctgcgac ctggcactgc tggaaaccta ctgtgccaca      240

ccagccaaga gcgagtgatg                                                  260


<210>  27
<211>  279
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27
ggagcaccag gcggaggatc tccagctcct gctcctacac cagctccagc accgacgcct       60

gctccagctg gcggaggacc ttctggtgca cctctttgtg gcggagagct ggtggatacc      120

ctgcagttcg tgtgtggcga ccggggcttc tactttagca gacctgccag cagagtgtcc      180

gccagatcta gaggcatcgt ggaagagtgc tgcttcagaa gctgcgacct ggcactgctg      240

gaaacctact gtgccacacc agccaagagc gagtgatga                             279


<210>  28
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28
ggagcaccag gcggatctcc agcaggatct ccaacctcta ccgaggaagg cacaagcgag       60

tctgccacac ctgagtctgg acctggcaca agcacagagc ctagcgaagg atctgcccca      120

ggttctcctg ccggctctcc tacaagtaca ggaccttctg gcgctccact gtgtggcgga      180

gaactggtgg ataccctgca gttcgtgtgc ggcgacagag gcttctactt tagcagaccc      240

gccagcagag tgtccgccag atctagagga atcgtggaag agtgctgctt cagaagctgc      300

gatctggcac tgctggaaac ctactgtgcc acaccagcca agagcgagtg atga            354


<210>  29
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29

Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys 
1               5                   10                  15      


Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu 
            20                  25                  30          


Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 
        35                  40                  45              


Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln 
    50                  55                  60                  


Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala 
65                  70                  75                  80  


Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 
                85                  90                  95      


Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser 
            100                 105                 110         


Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 
        115                 120                 125             


Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 
    130                 135                 140                 


Gly Gln Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg 
145                 150                 155                 160 


Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 
                165                 170                 175     


Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 
            180                 185                 190         


Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val 
        195                 200                 205             


Arg Ala Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg 
    210                 215                 220                 


Ala Gln Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly 
225                 230                 235                 240 


Ser Arg Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu 
                245                 250                 255     


Val Arg Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala 
            260                 265                 270         


Glu Ala Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu 
        275                 280                 285             


Asp Met Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala 
    290                 295                 300                 


Val Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His 
305                 310                 315         


<210>  30
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Arg Gln Ile Lys Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15  


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  32
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33

Arg Arg Leu Ser Tyr Ser Arg Arg Arg Phe 
1               5                   10  


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Pro Ile Arg Arg Arg Lys Lys Leu Arg Arg Leu Lys 
1               5                   10          


<210>  35
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

Arg Arg Arg Arg Asn Arg Thr Arg Arg Asn Arg Arg Arg Val Arg 
1               5                   10                  15  


<210>  37
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37

Lys Met Thr Arg Ala Gln Arg Arg Ala Ala Ala Arg Arg Asn Arg Trp 
1               5                   10                  15      


Thr Ala Arg 
            


<210>  38
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Thr Arg Arg Gln Arg Thr Arg Arg Ala Arg Arg Asn Arg 
1               5                   10              


<210>  39
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  40
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  41
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Lys Leu Ala Leu Lys Leu Ala Leu Lys Leu Ala Leu Ala Leu Lys Leu 
1               5                   10                  15      


Ala 
    


<210>  43
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43

Met Gly Leu Gly Leu His Leu Leu Val Leu Ala Ala Ala Leu Gln Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  44
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  45
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  46
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Ser Lys Arg Lys Val 
            20                  25          


<210>  47
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  47

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  48
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Lys Glu Thr Trp Phe Glu Thr Trp Phe Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  49
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Gly Arg Cys Cys Phe Tyr Thr Ala Gly Thr Leu Ser Leu Leu Leu 
1               5                   10                  15      


Leu Val Thr Ser Val Thr Leu Leu Val Ala 
            20                  25      


