                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  NOVEL RNA THERAPEUTICS AND USES THEREOF

<130>  X22935M

<150>  US 63/214,584
<151>  2021-06-24

<150>  US 63/214,555
<151>  2021-06-24

<160>  525   

<170>  PatentIn version 3.5

<210>  1
<211>  872
<212>  DNA
<213>  HOMO SAPIENS

<400>  1
ataccttaga ccctcagtca tgccagtgcc tgctctgtgc ctgctctggg ccctggcaat       60

ggtgacccgg cctgcctcag cggcccccat gggcggccca gaactggcac agcatgagga      120

gctgaccctg ctcttccatg ggaccctgca gctgggccag gccctcaacg gtgtgtacag      180

gaccacggag ggacggctga caaaggccag gaacagcctg ggtctctatg gccgcacaat      240

agaactcctg gggcaggagg tcagccgggg ccgggatgca gcccaggaac ttcgggcaag      300

cctgttggag actcagatgg aggaggatat tctgcagctg caggcagagg ccacagctga      360

ggtgctgggg gaggtggccc aggcacagaa ggtgctacgg gacagcgtgc agcggctaga      420

agtccagctg aggagcgcct ggctgggccc tgcctaccga gaatttgagg tcttaaaggc      480

tcacgctgac aagcagagcc acatcctatg ggccctcaca ggccacgtgc agcggcagag      540

gcgggagatg gtggcacagc agcatcggct gcgacagatc caggagagac tccacacagc      600

ggcgctccca gcctgaatct gcctggatgg aactgaggac caatcatgct gcaaggaaca      660

cttccacgcc ccgtgaggcc cctgtgcagg gaggagctgc ctgttcactg ggatcagcca      720

gggcgccggg ccccacttct gagcacagag cagagacaga cgcaggcggg gacaaaggca      780

gaggatgtag ccccattggg gaggggtgga ggaaggacat gtaccctttc atgcctacac      840

acccctcatt aaagcagagt cgtggcatct ca                                    872


<210>  2
<211>  1386
<212>  DNA
<213>  HOMO SAPIENS

<400>  2
atgttcacca tcaagctgct gctgttcatc gtgcccctcg tgatcagcag cagaatcgac       60

caggacaaca gcagcttcga cagcctgagc cccgagccca agagcagatt cgccatgctg      120

gacgacgtga agatcctggc caacggcctg ctgcagctgg gccacggcct gaaggatttc      180

gtgcacaaga ccaagggcca gatcaacgac atcttccaga agctgaacat cttcgaccag      240

agcttctacg acctgagcct gcagaccagc gagatcaaag aggaagagaa agagctgcgg      300

aggaccacct acaagctgca agtgaagaac gaggaagtga aaaacatgag cctggaactg      360

aacagcaagc tggaaagcct gctggaagaa aagattctgc tgcagcagaa agtgaagtac      420

ctggaagaac agctgaccaa cctgatccag aaccagcccg agacacccga gcaccccgaa      480

gtgaccagcc tgaaaacctt cgtggaaaag caggacaact ccatcaagga cctgctgcag      540

accgtggaag atcagtacaa gcagctgaac cagcagcact cccagatcaa agaaatcgag      600

aaccagctga ggcggaccag catccaggaa cccaccgaga tcagcctgtc cagcaagccc      660

agagccccca gaacaacccc attcctgcag ctgaatgaga tccggaacgt gaagcacgac      720

ggcatccctg ccgagtgcac caccatctac aacagaggcg agcacaccag cgggatgtac      780

gccatcagac ccagcaacag ccaggtgttc cacgtgtact gcgacgtgat cagcggcagc      840

ccctggacac tgatccagca cagaatcgat ggcagccaga acttcaacga gacatgggag      900

aactataagt acggcttcgg cagactggac ggcgagtttt ggctgggcct ggaaaagatc      960

tacagcatcg tgaagcagag caactacgtg ctgagaatcg agctggaaga ttggaaggac     1020

aacaagcact acatcgagta cagcttctac ctgggcaacc acgagacaaa ctacaccctg     1080

cacctggtgg ccatcaccgg caacgtgcca aacgccatcc ccgagaacaa ggatctggtg     1140

ttcagcacct gggaccacaa ggctaagggc cacttcaact gccccgaggg ctactctggc     1200

ggctggtggt ggcatgatga gtgcggcgag aacaacctga acggcaagta caacaagccc     1260

agggccaaga gcaagcctga gagaagaaga ggcctgtcct ggaagtccca gaacggcagg     1320

ctgtactcta tcaagagcac caagatgctg atccacccca ccgacagcga gagcttcgag     1380

tgataa                                                                1386


<210>  3
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  3
agctgaccct gctcttcc                                                     18


<210>  4
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  4
ggaccctgca gctgggcc                                                     18


<210>  5
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  5
agctgggcca ggccctca                                                     18


<210>  6
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  6
acggagggac ggctgaca                                                     18


<210>  7
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  7
cggagggacg gctgacaa                                                     18


<210>  8
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  8
ggacggctga caaaggcc                                                     18


<210>  9
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  9
cggctgacaa aggccagg                                                     18


<210>  10
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  10
ggctgacaaa ggccagga                                                     18


<210>  11
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  11
ctgacaaagg ccaggaac                                                     18


<210>  12
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  12
ggaacagcct gggtctct                                                     18


<210>  13
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  13
gaacagcctg ggtctcta                                                     18


<210>  14
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  14
agcctgggtc tctatggc                                                     18


<210>  15
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  15
cctgggtctc tatggccg                                                     18


<210>  16
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  16
ctgggtctct atggccgc                                                     18


<210>  17
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  17
tgggtctcta tggccgca                                                     18


<210>  18
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  18
gggtctctat ggccgcac                                                     18


<210>  19
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  19
ggtcagccgg ggccggga                                                     18


<210>  20
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  20
ggggccggga tgcagccc                                                     18


<210>  21
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  21
gccgggatgc agcccagg                                                     18


<210>  22
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  22
ccgggatgca gcccagga                                                     18


<210>  23
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  23
gggatgcagc ccaggaac                                                     18


<210>  24
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  24
ggatgcagcc caggaact                                                     18


<210>  25
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  25
gcccaggaac ttcgggca                                                     18


<210>  26
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  26
cccaggaact tcgggcaa                                                     18


<210>  27
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  27
ccaggaactt cgggcaag                                                     18


<210>  28
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  28
caggaacttc gggcaagc                                                     18


<210>  29
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  29
aggaacttcg ggcaagcc                                                     18


<210>  30
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  30
ggaacttcgg gcaagcct                                                     18


<210>  31
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  31
gaacttcggg caagcctg                                                     18


<210>  32
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  32
cttcgggcaa gcctgttg                                                     18


<210>  33
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  33
ttcgggcaag cctgttgg                                                     18


<210>  34
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  34
cgggcaagcc tgttggag                                                     18


<210>  35
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  35
caagcctgtt ggagactc                                                     18


<210>  36
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  36
agcctgttgg agactcag                                                     18


<210>  37
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  37
gcctgttgga gactcaga                                                     18


<210>  38
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  38
tgttggagac tcagatgg                                                     18


<210>  39
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  39
gttggagact cagatgga                                                     18


<210>  40
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  40
agactcagat ggaggagg                                                     18


<210>  41
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  41
gactcagatg gaggagga                                                     18


<210>  42
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  42
actcagatgg aggaggat                                                     18


<210>  43
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  43
ctcagatgga ggaggata                                                     18


<210>  44
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  44
tcagatggag gaggatat                                                     18


<210>  45
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  45
cagatggagg aggatatt                                                     18


<210>  46
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  46
agatggagga ggatattc                                                     18


<210>  47
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  47
gatggaggag gatattct                                                     18


<210>  48
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  48
atggaggagg atattctg                                                     18


<210>  49
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  49
ggaggaggat attctgca                                                     18


<210>  50
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  50
aggaggatat tctgcagc                                                     18


<210>  51
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  51
aggtggccca ggcacaga                                                     18


<210>  52
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  52
ccaggcacag aaggtgct                                                     18


<210>  53
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  53
agcggctaga agtccagc                                                     18


<210>  54
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  54
gcggctagaa gtccagct                                                     18


<210>  55
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  55
cggctagaag tccagctg                                                     18


<210>  56
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  56
ggctagaagt ccagctga                                                     18


<210>  57
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  57
gctagaagtc cagctgag                                                     18


<210>  58
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  58
aagtccagct gaggagcg                                                     18


<210>  59
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  59
agtccagctg aggagcgc                                                     18


<210>  60
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  60
cctggctggg ccctgcct                                                     18


<210>  61
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  61
gagaatttga ggtcttaa                                                     18


<210>  62
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  62
agaatttgag gtcttaaa                                                     18


<210>  63
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  63
aatttgaggt cttaaagg                                                     18


<210>  64
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  64
atttgaggtc ttaaaggc                                                     18


<210>  65
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  65
tttgaggtct taaaggct                                                     18


<210>  66
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  66
ttgaggtctt aaaggctc                                                     18


<210>  67
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  67
tgaggtctta aaggctca                                                     18


<210>  68
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  68
gaggtcttaa aggctcac                                                     18


<210>  69
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  69
ggtcttaaag gctcacgc                                                     18


<210>  70
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  70
tcttaaaggc tcacgctg                                                     18


<210>  71
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  71
cttaaaggct cacgctga                                                     18


<210>  72
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  72
ttaaaggctc acgctgac                                                     18


<210>  73
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  73
taaaggctca cgctgaca                                                     18


<210>  74
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  74
aaaggctcac gctgacaa                                                     18


<210>  75
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  75
aaggctcacg ctgacaag                                                     18


<210>  76
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  76
aggctcacgc tgacaagc                                                     18


<210>  77
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  77
gctcacgctg acaagcag                                                     18


<210>  78
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  78
ctcacgctga caagcaga                                                     18


<210>  79
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  79
tcacgctgac aagcagag                                                     18


<210>  80
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  80
cacgctgaca agcagagc                                                     18


<210>  81
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  81
acgctgacaa gcagagcc                                                     18


<210>  82
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  82
gctgacaagc agagccac                                                     18


<210>  83
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  83
ccctcacagg ccacgtgc                                                     18


<210>  84
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  84
cctcacaggc cacgtgca                                                     18


<210>  85
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  85
aggccacgtg cagcggca                                                     18


<210>  86
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  86
ggccacgtgc agcggcag                                                     18


<210>  87
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  87
cacgtgcagc ggcagagg                                                     18


<210>  88
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  88
cagcggcaga ggcgggag                                                     18


<210>  89
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  89
ggcagaggcg ggagatgg                                                     18


<210>  90
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  90
ggcgggagat ggtggcac                                                     18


<210>  91
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  91
gggagatggt ggcacagc                                                     18


<210>  92
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  92
agatggtggc acagcagc                                                     18


<210>  93
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  93
ggcacagcag catcggct                                                     18


<210>  94
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  94
cacagcagca tcggctgc                                                     18


<210>  95
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  95
cagcagcatc ggctgcga                                                     18


<210>  96
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  96
agcagcatcg gctgcgac                                                     18


<210>  97
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  97
gcagcatcgg ctgcgaca                                                     18


<210>  98
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  98
cagcatcggc tgcgacag                                                     18


<210>  99
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  99
agcatcggct gcgacaga                                                     18


<210>  100
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  100
gcatcggctg cgacagat                                                     18


<210>  101
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  101
catcggctgc gacagatc                                                     18


<210>  102
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  102
atcggctgcg acagatcc                                                     18


<210>  103
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  103
tcggctgcga cagatcca                                                     18


<210>  104
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  104
ggctgcgaca gatccagg                                                     18


<210>  105
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  105
ctgcgacaga tccaggag                                                     18


<210>  106
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  106
tgcgacagat ccaggaga                                                     18


<210>  107
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  107
gcgacagatc caggagag                                                     18


<210>  108
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  108
cccagcctga atctgcct                                                     18


<210>  109
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  109
agcctgaatc tgcctgga                                                     18


<210>  110
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  110
gcctgaatct gcctggat                                                     18


<210>  111
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  111
ctgcctggat ggaactga                                                     18


<210>  112
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  112
tcatgctgca aggaacac                                                     18


<210>  113
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  113
caaggaacac ttccacgc                                                     18


<210>  114
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  114
ggaacacttc cacgcccc                                                     18


<210>  115
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  115
tgcctgttca ctgggatc                                                     18


<210>  116
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  116
gcctgttcac tgggatca                                                     18


<210>  117
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  117
ctgttcactg ggatcagc                                                     18


<210>  118
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  118
tgttcactgg gatcagcc                                                     18


<210>  119
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  119
tgggatcagc cagggcgc                                                     18


<210>  120
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  120
gggatcagcc agggcgcc                                                     18


<210>  121
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  121
cattaaagca gagtcgtg                                                     18


<210>  122
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  122
attaaagcag agtcgtgg                                                     18


<210>  123
<211>  18
<212>  DNA
<213>  HOMO SAPIENS

<400>  123
taaagcagag tcgtggca                                                     18


<210>  124
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  124
ggagcugacc cugcucuucc a                                                 21


<210>  125
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  125
ccacggaggg acggcugaca a                                                 21


<210>  126
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  126
acggcugaca aaggccagga a                                                 21


<210>  127
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  127
ggcugacaaa ggccaggaac a                                                 21


<210>  128
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  128
caggaacagc cugggucucu a                                                 21


<210>  129
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  129
caggaacagc cugggucucu c                                                 21


<210>  130
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  130
aggaacagcc ugggucucua u                                                 21


<210>  131
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  131
aggaacagcc ugggucucua a                                                 21


<210>  132
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  132
gccugggucu cuauggccgc a                                                 21


<210>  133
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  133
cugggucucu auggccgcac a                                                 21


<210>  134
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  134
cuuggucucu auggccgcac a                                                 21


<210>  135
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  135
cuaggucucu auggccgcac a                                                 21


<210>  136
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  136
caaggucucu auggccgcac a                                                 21


<210>  137
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  137
cccggucucu auggccgcac a                                                 21


<210>  138
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  138
cauggucucu auggccgcac a                                                 21


<210>  139
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  139
cagggucucu auggccgcac a                                                 21


<210>  140
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  140
cgaggucucu auggccgcac a                                                 21


<210>  141
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  141
cggggucucu auggccgcac a                                                 21


<210>  142
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  142
ccaggucucu auggccgcac a                                                 21


<210>  143
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  143
ccgggaugca gcccaggaac u                                                 21


<210>  144
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  144
cgggaugcag cccaggaacu u                                                 21


<210>  145
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  145
agcccaggaa cuucgggcaa a                                                 21


<210>  146
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  146
gcccaggaac uucgggcaag a                                                 21


<210>  147
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  147
caggaacuuc gggcaagccu a                                                 21


<210>  148
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  148
aggaacuucg ggcaagccug a                                                 21


<210>  149
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  149
aacuucgggc aagccuguug a                                                 21


<210>  150
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  150
acuucgggca agccuguugg a                                                 21


<210>  151
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  151
uucgggcaag ccuguuggag a                                                 21


<210>  152
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  152
ggcaagccug uuggagacuc a                                                 21


<210>  153
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  153
caagccuguu ggagacucag a                                                 21


<210>  154
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  154
aagccuguug gagacucaga u                                                 21


<210>  155
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  155
ccuguuggag acucagaugg a                                                 21


<210>  156
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  156
cuguuggaga cucagaugga a                                                 21


<210>  157
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  157
ggagacucag auggaggagg a                                                 21


<210>  158
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  158
gagacucaga uggaggagga u                                                 21


<210>  159
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  159
agacucagau ggaggaggau a                                                 21


<210>  160
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  160
gacucagaug gaggaggaua u                                                 21


<210>  161
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  161
acucagaugg aggaggauau u                                                 21


<210>  162
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  162
acucagaugg aggaggauau a                                                 21


<210>  163
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  163
ucagauggag gaggauauuc u                                                 21


<210>  164
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  164
gcagauggag gaggauauuc a                                                 21


<210>  165
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  165
ucagauggag gaggauauuc a                                                 21


<210>  166
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  166
ucagauggag gaggauauuc c                                                 21


<210>  167
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  167
cagauggagg aggauauucu g                                                 21


<210>  168
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  168
cagauggagg aggauauucu a                                                 21


<210>  169
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  169
auggaggagg auauucugca g                                                 21


<210>  170
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  170
auggaggagg auauucugca a                                                 21


<210>  171
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  171
auggaggagg cuauucugca g                                                 21


<210>  172
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  172
auggaggagg auauucugca g                                                 21


<210>  173
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  173
auggaggagg guauucugca g                                                 21


<210>  174
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  174
agauggagga ggauauucug cag                                               23


<210>  175
<211>  24
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  175
cagauggagg aggauauucu gcag                                              24


<210>  176
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  176
ccagauggag gaggauauuc ugcag                                             25


<210>  177
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  177
ggaggaggau auucugcagc u                                                 21


<210>  178
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  178
gcccaggcac agaaggugcu a                                                 21


<210>  179
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  179
agcggcuaga aguccagcug a                                                 21


<210>  180
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  180
gcggcuagaa guccagcuga a                                                 21


<210>  181
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  181
cggcuagaag uccagcugag a                                                 21


<210>  182
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  182
ccgagaauuu gaggucuuaa a                                                 21


<210>  183
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  183
cgagaauuug aggucuuaaa g                                                 21


<210>  184
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  184
ggagaauuug aggucuuaaa a                                                 21


<210>  185
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  185
cgagaauuug aggucuuaaa a                                                 21


<210>  186
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  186
agaauuugag gucuuaaagg a                                                 21


<210>  187
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  187
gaauuugagg ucuuaaaggc a                                                 21


<210>  188
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  188
aauuugaggu cuuaaaggcu a                                                 21


<210>  189
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  189
auuugagguc uuaaaggcuc a                                                 21


<210>  190
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  190
aucugagguc uuaaaggcuc a                                                 21


<210>  191
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  191
accugagguc uuaaaggcuc a                                                 21


<210>  192
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  192
uuugaggucu uaaaggcuca a                                                 21


<210>  193
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  193
gaggucuuaa aggcucacgc u                                                 21


<210>  194
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  194
gaggucuuaa aggcucacgc a                                                 21


<210>  195
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  195
ggucuuaaag gcucacgcug a                                                 21


<210>  196
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  196
ugucuuaaag gcucacgcug c                                                 21


<210>  197
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  197
gucuuaaagg cucacgcuga a                                                 21


<210>  198
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  198
ucuuaaaggc ucacgcugac a                                                 21


<210>  199
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  199
ccgaaaggcu cacgcugaca a                                                 21


<210>  200
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  200
cuuaaaggcu cacgcugaca a                                                 21


<210>  201
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  201
cacaaaggcu cacgcugaca a                                                 21


<210>  202
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  202
ccuaaaggcu cacgcugaca a                                                 21


<210>  203
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  203
cugaaaggcu cacgcugaca a                                                 21


<210>  204
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  204
cucaaaggcu cacgcugaca a                                                 21


<210>  205
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  205
ccaaaaggcu cacgcugaca a                                                 21


<210>  206
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  206
caaaaaggcu cacgcugaca a                                                 21


<210>  207
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  207
cgcaaaggcu cacgcugaca a                                                 21


<210>  208
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  208
cgaaaaggcu cacgcugaca a                                                 21


<210>  209
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  209
cagaaaggcu cacgcugaca a                                                 21


<210>  210
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  210
cccaaaggcu cacgcugaca a                                                 21


<210>  211
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  211
cguaaaggcu cacgcugaca a                                                 21


<210>  212
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  212
cggaaaggcu cacgcugaca a                                                 21


<210>  213
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  213
uuaaaggcuc acgcugacaa a                                                 21


<210>  214
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  214
aggcucacgc ugacaagcag a                                                 21


<210>  215
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  215
ugcagcggca gaggcgggag a                                                 21


<210>  216
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  216
gcggcagagg cgggagaugg u                                                 21


<210>  217
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  217
gaggcgggag augguggcac a                                                 21


<210>  218
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  218
gcgggagaug guggcacagc a                                                 21


<210>  219
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  219
guggcacagc agcaucggcu a                                                 21


<210>  220
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  220
cagcagcauc ggcugcgaca a                                                 21


<210>  221
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  221
agcagcaucg gcugcgacag a                                                 21


<210>  222
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  222
gcagcaucgg cugcgacaga a                                                 21


<210>  223
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  223
cagcaucggc ugcgacagau a                                                 21


<210>  224
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  224
agcaucggcu gcgacagauc a                                                 21


<210>  225
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  225
gcaucggcug cgacagaucc a                                                 21


<210>  226
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  226
caucggcugc gacagaucca a                                                 21


<210>  227
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  227
ucggcugcga cagauccagg a                                                 21


<210>  228
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  228
ggcugcgaca gauccaggag a                                                 21


<210>  229
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  229
gcugcgacag auccaggaga a                                                 21


<210>  230
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  230
cugcgacaga uccaggagag a                                                 21


<210>  231
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  231
uggaagagca gggucagcuc cuc                                               23


<210>  232
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  232
uugucagccg ucccuccgug guc                                               23


<210>  233
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  233
uuccuggccu uugucagccg ucc                                               23


<210>  234
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  234
uguuccuggc cuuugucagc cgu                                               23


<210>  235
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  235
uagagaccca ggcuguuccu ggc                                               23


<210>  236
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  236
gagagaccca ggcuguuccu ggc                                               23


<210>  237
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  237
auagagaccc aggcuguucc ugg                                               23


<210>  238
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  238
uuagagaccc aggcuguucc ugg                                               23


<210>  239
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  239
ugcggccaua gagacccagg cug                                               23


<210>  240
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  240
ugugcggcca uagagaccca ggc                                               23


<210>  241
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  241
ugugcggcca uagagaccaa ggc                                               23


<210>  242
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  242
ugugcggcca uagagaccca gug                                               23


<210>  243
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  243
ugugcggcca uagagaccca gcc                                               23


<210>  244
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  244
ugugcggcca uagagaccca guu                                               23


<210>  245
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  245
ugugcggcca uagagaccca gag                                               23


<210>  246
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  246
ugugcggcca uagagaccca gau                                               23


<210>  247
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  247
ugugcggcca uagagaccca ggu                                               23


<210>  248
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  248
ugugcggcca uagagaccca gaa                                               23


<210>  249
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  249
ugugcggcca uagagaccua ggc                                               23


<210>  250
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  250
ugugcggcca uagagaccca gcg                                               23


<210>  251
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  251
ugugcggcca uagagaccuu ggc                                               23


<210>  252
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  252
ugugcggcca uagagaccca gca                                               23


<210>  253
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  253
ugugcggcca uagagaccca gac                                               23


<210>  254
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  254
ugugcggcca uagagaccca gcu                                               23


<210>  255
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  255
ugugcggcca uagagaccgg ggc                                               23


<210>  256
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  256
ugugcggcca uagagaccca gua                                               23


<210>  257
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  257
ugugcggcca uagagaccau ggc                                               23


<210>  258
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  258
ugugcggcca uagagacccu ggc                                               23


<210>  259
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  259
ugugcggcca uagagaccuc ggc                                               23


<210>  260
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  260
ugugcggcca uagagacccc ggc                                               23


<210>  261
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  261
ugugcggcca uagagaccug ggc                                               23


<210>  262
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  262
aguuccuggg cugcaucccg gcc                                               23


<210>  263
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  263
aaguuccugg gcugcauccc ggc                                               23


<210>  264
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  264
uuugcccgaa guuccugggc ugc                                               23


<210>  265
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  265
ucuugcccga aguuccuggg cug                                               23


<210>  266
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  266
uaggcuugcc cgaaguuccu ggg                                               23


<210>  267
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  267
ucaggcuugc ccgaaguucc ugg                                               23


<210>  268
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  268
ucaacaggcu ugcccgaagu ucc                                               23


<210>  269
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  269
uccaacaggc uugcccgaag uuc                                               23


<210>  270
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  270
ucuccaacag gcuugcccga agu                                               23


<210>  271
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  271
ugagucucca acaggcuugc ccg                                               23


<210>  272
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  272
ucugagucuc caacaggcuu gcc                                               23


<210>  273
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  273
aucugagucu ccaacaggcu ugc                                               23


<210>  274
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  274
uccaucugag ucuccaacag gcu                                               23


<210>  275
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  275
uuccaucuga gucuccaaca ggc                                               23


<210>  276
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  276
uccuccucca ucugagucuc caa                                               23


<210>  277
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  277
auccuccucc aucugagucu cca                                               23


<210>  278
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  278
uauccuccuc caucugaguc ucc                                               23


<210>  279
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  279
auauccuccu ccaucugagu cuc                                               23


<210>  280
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  280
aauauccucc uccaucugag ucu                                               23


<210>  281
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  281
uauauccucc uccaucugag ucu                                               23


<210>  282
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  282
agaauauccu ccuccaucug agu                                               23


<210>  283
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  283
ugaauauccu ccuccaucug cgu                                               23


<210>  284
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  284
ugaauauccu ccuccaucug agu                                               23


<210>  285
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  285
ggaauauccu ccuccaucug agu                                               23


<210>  286
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  286
cagaauaucc uccuccaucu gag                                               23


<210>  287
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  287
uagaauaucc uccuccaucu gag                                               23


<210>  288
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  288
cugcagaaua uccuccucca ucu                                               23


<210>  289
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  289
uugcagaaua uccuccucca ucu                                               23


<210>  290
<211>  26
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  290
cugcagaaua uccuccucca ucuttt                                            26


<210>  291
<211>  25
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  291
cugcagaaua uccuccucca ucutt                                             25


<210>  292
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  292
agcugcagaa uauccuccuc cau                                               23


<210>  293
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  293
uagcaccuuc ugugccuggg cca                                               23


<210>  294
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  294
ucagcuggac uucuagccgc ugc                                               23


<210>  295
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  295
uucagcugga cuucuagccg cug                                               23


<210>  296
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  296
ucucagcugg acuucuagcc gcu                                               23


<210>  297
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  297
uuuaagaccu caaauucucg gua                                               23


<210>  298
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  298
cuuuaagacc ucaaauucuc ggu                                               23


<210>  299
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  299
uuuuaagacc ucaaauucuc cgu                                               23


<210>  300
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  300
uuuuaagacc ucaaauucuc ggu                                               23


<210>  301
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  301
uccuuuaaga ccucaaauuc ucg                                               23


<210>  302
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  302
ugccuuuaag accucaaauu cuc                                               23


<210>  303
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  303
uagccuuuaa gaccucaaau ucu                                               23


<210>  304
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  304
ugagccuuua agaccucaaa uuc                                               23


<210>  305
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  305
ugagccuuua agaccucaga uuc                                               23


<210>  306
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  306
ugagccuuua agaccucagg uuc                                               23


<210>  307
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  307
uugagccuuu aagaccucaa auu                                               23


<210>  308
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  308
agcgugagcc uuuaagaccu caa                                               23


<210>  309
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  309
ugcgugagcc uuuaagaccu caa                                               23


<210>  310
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  310
ucagcgugag ccuuuaagac cuc                                               23


<210>  311
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  311
gcagcgugag ccuuuaagac auc                                               23


<210>  312
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  312
uucagcguga gccuuuaaga ccu                                               23


<210>  313
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  313
ugucagcgug agccuuuaag acc                                               23


<210>  314
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  314
uugucagcgu gagccuuucg gac                                               23


<210>  315
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  315
uugucagcgu gagccuuuaa gaa                                               23


<210>  316
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  316
uugucagcgu gagccuuugu gac                                               23


<210>  317
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  317
uugucagcgu gagccuuuaa ggu                                               23


<210>  318
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  318
uugucagcgu gagccuuuag gac                                               23


<210>  319
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  319
uugucagcgu gagccuuuaa gca                                               23


<210>  320
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  320
uugucagcgu gagccuuuaa gag                                               23


<210>  321
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  321
uugucagcgu gagccuuuca gac                                               23


<210>  322
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  322
uugucagcgu gagccuuuaa ggg                                               23


<210>  323
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  323
uugucagcgu gagccuuuga gac                                               23


<210>  324
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  324
uugucagcgu gagccuuuug gac                                               23


<210>  325
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  325
uugucagcgu gagccuuuaa gua                                               23


<210>  326
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  326
uugucagcgu gagccuuuaa ggc                                               23


<210>  327
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  327
uugucagcgu gagccuuuaa gcu                                               23


<210>  328
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  328
uugucagcgu gagccuuuaa gga                                               23


<210>  329
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  329
uugucagcgu gagccuuuaa gug                                               23


<210>  330
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  330
uugucagcgu gagccuuuuu gac                                               23


<210>  331
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  331
uugucagcgu gagccuuugc gac                                               23


<210>  332
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  332
uugucagcgu gagccuuuuc gac                                               23


<210>  333
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  333
uugucagcgu gagccuuuaa gcg                                               23


<210>  334
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  334
uugucagcgu gagccuuucu gac                                               23


<210>  335
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  335
uugucagcgu gagccuuugg gac                                               23


<210>  336
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  336
uugucagcgu gagccuuuaa gac                                               23


<210>  337
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  337
uugucagcgu gagccuuuaa gcc                                               23


<210>  338
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  338
uugucagcgu gagccuuuaa gau                                               23


<210>  339
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  339
uugucagcgu gagccuuuac gac                                               23


<210>  340
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  340
uugucagcgu gagccuuuaa guc                                               23


<210>  341
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  341
uugucagcgu gagccuuuaa guu                                               23


<210>  342
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  342
uugucagcgu gagccuuucc gac                                               23


<210>  343
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  343
uuugucagcg ugagccuuua aga                                               23


<210>  344
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  344
ucugcuuguc agcgugagcc uuu                                               23


<210>  345
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  345
ucucccgccu cugccgcugc acg                                               23


<210>  346
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  346
accaucuccc gccucugccg cug                                               23


<210>  347
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  347
ugugccacca ucucccgccu cug                                               23


<210>  348
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  348
ugcugugcca ccaucucccg ccu                                               23


<210>  349
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  349
uagccgaugc ugcugugcca cca                                               23


<210>  350
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  350
uugucgcagc cgaugcugcu gug                                               23


<210>  351
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  351
ucugucgcag ccgaugcugc ugu                                               23


<210>  352
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  352
uucugucgca gccgaugcug cug                                               23


<210>  353
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  353
uaucugucgc agccgaugcu gcu                                               23


<210>  354
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  354
ugaucugucg cagccgaugc ugc                                               23


<210>  355
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  355
uggaucuguc gcagccgaug cug                                               23


<210>  356
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  356
uuggaucugu cgcagccgau gcu                                               23


<210>  357
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  357
uccuggaucu gucgcagccg aug                                               23


<210>  358
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  358
ucuccuggau cugucgcagc cga                                               23


<210>  359
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  359
uucuccugga ucugucgcag ccg                                               23


<210>  360
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide

<400>  360
ucucuccugg aucugucgca gcc                                               23


<210>  361
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mA*mU*mGmGmAmGfGmAfGfGfAmUmAmUmUmCmUmGmC*mA*mA


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  361
auggaggagg auauucugca a                                                 21


<210>  362
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mC*mC*mGmAmGmAfAmUfUfUfGmAmGmGmUmCmUmUmA*mA*mA


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  362
ccgagaauuu gaggucuuaa a                                                 21


<210>  363
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mA*mU*mGmGmAmGfGmAfGfGfAmUmAmUmUmCmUmGmC*mA*mA


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  363
auggaggagg auauucugca a                                                 21


<210>  364
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mG*mG*mUmCmUmUfAmAfAfGfGmCmUmCmAmCmGmCmU*mG*mA


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  364
ggucuuaaag gcucacgcug a                                                 21


<210>  365
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mA*mU*mGmGmAmGfGmAfGfGfAmUmAmUmUmCmUmGmC*mA*mG


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  365
auggaggagg auauucugca g                                                 21


<210>  366
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mC*mG*mAmGmAmAfUmUfUfGfAmGmGmUmCmUmUmAmA*mA*mG


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  366
cgagaauuug aggucuuaaa g                                                 21


<210>  367
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: 
       [Phos]mU*fU*mGmCmAfGmAmAmUmAmUmCmCfUmCfCmUmCmCmAmU*mC*mU


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  367
uugcagaaua uccuccucca ucu                                               23


<210>  368
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: 
       [Phos]mU*fU*mUmAmAfGmAmCmCmUmCmAmAfAmUfUmCmUmCmGmG*mU*mA


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phopshate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  368
uuuaagaccu caaauucucg gua                                               23


<210>  369
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mU*fU*mGmCmAfGmAmAmUmAmUmCmCfUmCfCmUmCmCmAmU*mC*mU


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  369
uugcagaaua uccuccucca ucu                                               23


<210>  370
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mU*fC*mAmGmCfGmUmGmAmGmCmCmUfUmUfAmAmGmAmCmC*mU*mC


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  370
ucagcgugag ccuuuaagac cuc                                               23


<210>  371
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mC*fU*mGmCmAfGmAmAmUmAmUmCmCfUmCfCmUmCmCmAmU*mC*mU


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  371
cugcagaaua uccuccucca ucu                                               23


<210>  372
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mC*fU*mUmUmAfAmGmAmCmCmUmCmAfAmAfUmUmCmUmCmG*mG*mU


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  372
cuuuaagacc ucaaauucuc ggu                                               23


<210>  373
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mU*mC*mAmGmAmUmGmGfAfGfGmAmGmGmAmUmAmUmUmCmU


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  373
ucagauggag gaggauauuc u                                                 21


<210>  374
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mG*mC*mAmGmAmUfGmGfAfGfGmAmGmGmAmUmAmUmU*mC*mA


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  374
gcagauggag gaggauauuc a                                                 21


<210>  375
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mU*mC*mAmGmAmUfGmGfAfGfGmAmGmGmAmUmAmUmUmCmU


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  375
ucagauggag gaggauauuc u                                                 21


<210>  376
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mU*mC*mAmGmAmUfGmGfAfGfGmAmGmGmAmUmAmUmU*mC*mC


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  376
ucagauggag gaggauauuc c                                                 21


<210>  377
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mU*mC*mAmGmAmUfGmGfAfGfGmAmGmGmAmUmAmUmUmCmUP


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  377
ucagauggag gaggauauuc u                                                 21


<210>  378
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mC*mA*mGmAmUmGfGmAfGfGfAmGmGmAmUmAmUmUmC*mU*mA


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  378
cagauggagg aggauauucu a                                                 21


<210>  379
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mA*mU*mGmGmAmGfGmAfGfGfAmUmAmUmUmCmUmGmC*mA*mA


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  379
auggaggagg auauucugca a                                                 21


<210>  380
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mC*mC*mGmAmGmAfAmUfUfUfGmAmGmGmUmCmUmUmA*mA*mA


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  380
ccgagaauuu gaggucuuaa a                                                 21


<210>  381
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mC*mG*mAmGmAmAfUmUfUfGfAmGmGmUmCmUmUmAmA*mA*mG


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  381
cgagaauuug aggucuuaaa g                                                 21


<210>  382
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mC*mG*mAmGmAmAfUmUfUfGfAmGmGmUmCmUmUmAmA*mA*mG


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  382
cgagaauuug aggucuuaaa g                                                 21


<210>  383
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mG*mG*mAmGmAmAfUmUfUfGfAmGmGmUmCmUmUmAmA*mA*mA


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  383
ggagaauuug aggucuuaaa a                                                 21


<210>  384
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mC*mG*mAmGmAmAfUmUfUfGfAmGmGmUmCmUmUmAmA*mA*mA


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  384
cgagaauuug aggucuuaaa a                                                 21


<210>  385
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mC*mG*mAmGmAmAfUmUfUfGfAmGmGmUmCmUmUmAmAmAmG


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  385
cgagaauuug aggucuuaaa g                                                 21


<210>  386
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mC*mG*mAmGmAmAmUmUfUfGfAmGmGmUmCmUmUmAmAmAmG


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  386
cgagaauuug aggucuuaaa g                                                 21


<210>  387
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mC*mG*mAmGmAmAfUmUfUfGfAmGmGmUmCmUmUmAmAmAmG


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  387
cgagaauuug aggucuuaaa g                                                 21


<210>  388
<211>  21
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: mC*mG*mAmGmAmAmUmUfUfGfAmGmGmUmCmUmUmAmAmAmG


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  388
cgagaauuug aggucuuaaa g                                                 21


<210>  389
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: 
       PmA*fG*mAmAmUfAmUmCmCmUmCmCmUfCmCfAmUmCmUmGmA*mG*mU


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  389
agaauauccu ccuccaucug agu                                               23


<210>  390
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: 
       PmU*fG*mAmAmUfAmUmCmCmUmCmCmUfCmCfAmUmCmUmGmC*mG*mU


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  390
ugaauauccu ccuccaucug cgu                                               23


<210>  391
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: 
       PmA*fG*mAmAmUfAmUmCmCmUmCmCmUfCmCfAmUmCmUmGmA*mG*mU


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  391
agaauauccu ccuccaucug agu                                               23


<210>  392
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: 
       PmG*fG*mAmAmUfAmUmCmCmUmCmCmUfCmCfAmUmCmUmGmA*mG*mU


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  392
ggaauauccu ccuccaucug agu                                               23


<210>  393
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: 
       PmA*fG*mAmAmUmAmUmCmCmUmCmCmUfCmCmAmUmCmUmGmA*mG*mU


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phopphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  393
agaauauccu ccuccaucug agu                                               23


<210>  394
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: 
       PmU*fA*mGmAmAfUmAmUmCmCmUmCmCfUmCfCmAmUmCmUmG*mA*mG


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  394
uagaauaucc uccuccaucu gag                                               23


<210>  395
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: 
       PmU*fU*mGmCmAfGmAmAmUmAmUmCmCfUmCfCmUmCmCmAmU*mC*mU


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  395
uugcagaaua uccuccucca ucu                                               23


<210>  396
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: 
       PmU*fU*mUmAmAfGmAmCmCmUmCmAmAfAmUfUmCmUmCmGmG*mU*mA


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  396
uuuaagaccu caaauucucg gua                                               23


<210>  397
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: 
       PmC*fU*mUmUmAfAmGmAmCmCmUmCmAfAmAfUmUmCmUmCmG*mG*mU


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-Phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  397
cuuuaagacc ucaaauucuc ggu                                               23


<210>  398
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: 
       PmC*fU*mUmUmAfAmGmAmCmCmUmCmAfAmAfUmUmCmUmCmG*mG*mU


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  398
cuuuaagacc ucaaauucuc ggu                                               23


<210>  399
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: 
       PmU*fU*mUmUmAfAmGmAmCmCmUmCmAfAmAfUmUmCmUmCmC*mG*mU


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  399
uuuuaagacc ucaaauucuc cgu                                               23


<210>  400
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: 
       PmU*fU*mUmUmAfAmGmAmCmCmUmCmAfAmAfUmUmCmUmCmG*mG*mU


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  400
uuuuaagacc ucaaauucuc ggu                                               23


<210>  401
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: 
       PmC*fU*mUmUmAfAmGmAmCmCmUmCmAfAmAfUmUmCmUmCmG*mG*mU


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  401
cuuuaagacc ucaaauucuc ggu                                               23


<210>  402
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: 
       PmC*fU*mUmUmAfAmGmAmCmCmUmCmAfAmAfUmUmCmUmCmG*mG*mU


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  402
cuuuaagacc ucaaauucuc ggu                                               23


<210>  403
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: 
       PmC*fU*mUmUmAmAmGmAmCmCmUmCmAfAmAmUmUmCmUmCmG*mG*mU


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  403
cuuuaagacc ucaaauucuc ggu                                               23


<210>  404
<211>  23
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Synthetic Oligonucleotide; sequence (5' to 3') with 
       modifications: 
       PmC*fU*mUmUmAmAmGmAmCmCmUmCmAfAmAmUmUmCmUmCmG*mG*mU


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  404
cuuuaagacc ucaaauucuc ggu                                               23


<210>  405
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  405
ggaagagcag ggucagcu                                                     18


<210>  406
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  406
ggcccagcug cagggucc                                                     18


<210>  407
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  407
ugagggccug gcccagcu                                                     18


<210>  408
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  408
ugucagccgu cccuccgu                                                     18


<210>  409
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  409
uugucagccg ucccuccg                                                     18


<210>  410
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  410
ggccuuuguc agccgucc                                                     18


<210>  411
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  411
ccuggccuuu gucagccg                                                     18


<210>  412
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  412
uccuggccuu ugucagcc                                                     18


<210>  413
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  413
guuccuggcc uuugucag                                                     18


<210>  414
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  414
agagacccag gcuguucc                                                     18


<210>  415
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  415
uagagaccca ggcuguuc                                                     18


<210>  416
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  416
gccauagaga cccaggcu                                                     18


<210>  417
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  417
cggccauaga gacccagg                                                     18


<210>  418
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  418
gcggccauag agacccag                                                     18


<210>  419
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  419
ugcggccaua gagaccca                                                     18


<210>  420
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  420
gugcggccau agagaccc                                                     18


<210>  421
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  421
ucccggcccc ggcugacc                                                     18


<210>  422
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  422
gggcugcauc ccggcccc                                                     18


<210>  423
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  423
ccugggcugc aucccggc                                                     18


<210>  424
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  424
uccugggcug caucccgg                                                     18


<210>  425
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  425
guuccugggc ugcauccc                                                     18


<210>  426
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  426
aguuccuggg cugcaucc                                                     18


<210>  427
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  427
ugcccgaagu uccugggc                                                     18


<210>  428
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  428
uugcccgaag uuccuggg                                                     18


<210>  429
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  429
cuugcccgaa guuccugg                                                     18


<210>  430
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  430
gcuugcccga aguuccug                                                     18


<210>  431
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  431
ggcuugcccg aaguuccu                                                     18


<210>  432
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  432
aggcuugccc gaaguucc                                                     18


<210>  433
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  433
caggcuugcc cgaaguuc                                                     18


<210>  434
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  434
caacaggcuu gcccgaag                                                     18


<210>  435
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  435
ccaacaggcu ugcccgaa                                                     18


<210>  436
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  436
cuccaacagg cuugcccg                                                     18


<210>  437
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  437
gagucuccaa caggcuug                                                     18


<210>  438
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  438
cugagucucc aacaggcu                                                     18


<210>  439
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  439
ucugagucuc caacaggc                                                     18


<210>  440
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  440
ccaucugagu cuccaaca                                                     18


<210>  441
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  441
uccaucugag ucuccaac                                                     18


<210>  442
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  442
ccuccuccau cugagucu                                                     18


<210>  443
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  443
uccuccucca ucugaguc                                                     18


<210>  444
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  444
auccuccucc aucugagu                                                     18


<210>  445
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  445
uauccuccuc caucugag                                                     18


<210>  446
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  446
auauccuccu ccaucuga                                                     18


<210>  447
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  447
aauauccucc uccaucug                                                     18


<210>  448
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  448
gaauauccuc cuccaucu                                                     18


<210>  449
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  449
agaauauccu ccuccauc                                                     18


<210>  450
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  450
cagaauaucc uccuccau                                                     18


<210>  451
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  451
ugcagaauau ccuccucc                                                     18


<210>  452
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  452
gcugcagaau auccuccu                                                     18


<210>  453
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  453
ucugugccug ggccaccu                                                     18


<210>  454
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  454
agcaccuucu gugccugg                                                     18


<210>  455
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  455
gcuggacuuc uagccgcu                                                     18


<210>  456
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  456
agcuggacuu cuagccgc                                                     18


<210>  457
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  457
cagcuggacu ucuagccg                                                     18


<210>  458
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  458
ucagcuggac uucuagcc                                                     18


<210>  459
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  459
cucagcugga cuucuagc                                                     18


<210>  460
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  460
cgcuccucag cuggacuu                                                     18


<210>  461
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  461
gcgcuccuca gcuggacu                                                     18


<210>  462
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  462
aggcagggcc cagccagg                                                     18


<210>  463
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  463
uuaagaccuc aaauucuc                                                     18


<210>  464
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  464
uuuaagaccu caaauucu                                                     18


<210>  465
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  465
ccuuuaagac cucaaauu                                                     18


<210>  466
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  466
gccuuuaaga ccucaaau                                                     18


<210>  467
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  467
agccuuuaag accucaaa                                                     18


<210>  468
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  468
gagccuuuaa gaccucaa                                                     18


<210>  469
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  469
ugagccuuua agaccuca                                                     18


<210>  470
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  470
gugagccuuu aagaccuc                                                     18


<210>  471
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  471
gcgugagccu uuaagacc                                                     18


<210>  472
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  472
cagcgugagc cuuuaaga                                                     18


<210>  473
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  473
ucagcgugag ccuuuaag                                                     18


<210>  474
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  474
gucagcguga gccuuuaa                                                     18


<210>  475
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  475
ugucagcgug agccuuua                                                     18


<210>  476
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  476
uugucagcgu gagccuuu                                                     18


<210>  477
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  477
cuugucagcg ugagccuu                                                     18


<210>  478
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  478
gcuugucagc gugagccu                                                     18


<210>  479
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  479
cugcuuguca gcgugagc                                                     18


<210>  480
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  480
ucugcuuguc agcgugag                                                     18


<210>  481
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  481
cucugcuugu cagcguga                                                     18


<210>  482
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  482
gcucugcuug ucagcgug                                                     18


<210>  483
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  483
ggcucugcuu gucagcgu                                                     18


<210>  484
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  484
guggcucugc uugucagc                                                     18


<210>  485
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  485
gcacguggcc ugugaggg                                                     18


<210>  486
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  486
ugcacguggc cugugagg                                                     18


<210>  487
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  487
ugccgcugca cguggccu                                                     18


<210>  488
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  488
cugccgcugc acguggcc                                                     18


<210>  489
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  489
ccucugccgc ugcacgug                                                     18


<210>  490
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  490
cucccgccuc ugccgcug                                                     18


<210>  491
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  491
ccaucucccg ccucugcc                                                     18


<210>  492
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  492
gugccaccau cucccgcc                                                     18


<210>  493
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  493
gcugugccac caucuccc                                                     18


<210>  494
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  494
gcugcugugc caccaucu                                                     18


<210>  495
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  495
agccgaugcu gcugugcc                                                     18


<210>  496
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  496
gcagccgaug cugcugug                                                     18


<210>  497
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  497
ucgcagccga ugcugcug                                                     18


<210>  498
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  498
gucgcagccg augcugcu                                                     18


<210>  499
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  499
ugucgcagcc gaugcugc                                                     18


<210>  500
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  500
cugucgcagc cgaugcug                                                     18


<210>  501
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  501
ucugucgcag ccgaugcu                                                     18


<210>  502
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  502
aucugucgca gccgaugc                                                     18


<210>  503
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  503
gaucugucgc agccgaug                                                     18


<210>  504
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  504
ggaucugucg cagccgau                                                     18


<210>  505
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  505
uggaucuguc gcagccga                                                     18


<210>  506
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  506
ccuggaucug ucgcagcc                                                     18


<210>  507
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  507
cuccuggauc ugucgcag                                                     18


<210>  508
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  508
ucuccuggau cugucgca                                                     18


<210>  509
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  509
cucuccugga ucugucgc                                                     18


<210>  510
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  510
aggcagauuc aggcuggg                                                     18


<210>  511
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  511
uccaggcaga uucaggcu                                                     18


<210>  512
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  512
auccaggcag auucaggc                                                     18


<210>  513
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  513
ucaguuccau ccaggcag                                                     18


<210>  514
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  514
guguuccuug cagcauga                                                     18


<210>  515
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  515
gcguggaagu guuccuug                                                     18


<210>  516
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  516
ggggcgugga aguguucc                                                     18


<210>  517
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  517
gaucccagug aacaggca                                                     18


<210>  518
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  518
ugaucccagu gaacaggc                                                     18


<210>  519
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  519
gcugauccca gugaacag                                                     18


<210>  520
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  520
ggcugauccc agugaaca                                                     18


<210>  521
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  521
gcgcccuggc ugauccca                                                     18


<210>  522
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  522
ggcgcccugg cugauccc                                                     18


<210>  523
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  523
cacgacucug cuuuaaug                                                     18


<210>  524
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  524
ccacgacucu gcuuuaau                                                     18


<210>  525
<211>  18
<212>  RNA
<213>  Homo sapiens

<400>  525
ugccacgacu cugcuuua                                                     18


