                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  NOVEL THERAPEUTIC DELIVERY MOIETIES AND USES THEREOF

<130>  X22934

<150>  63/214,555
<151>  2021-06-24

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage and
       a 5'-phosphate substitution

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  1
auaaaaucua cagucauagg aau                                               23


<210>  2
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  2
uccuaugacu guagauuuua u                                                 21


<210>  3
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage and
       a 5'-phosphate substitution

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  3
acguagguca agauauccac ugg                                               23


<210>  4
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  4
aguggauauc uugaccuacg u                                                 21


<210>  5
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage and
       a 5'-phosphate substitution

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-F modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-OMe modified nucleotide

<400>  5
aauaaggagg uacucaacuu guu                                               23


<210>  6
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-F modified nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-OMe modified nucleotide with a 3'-phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-OMe modified nucleotide

<400>  6
caaguugagu accuccuuau u                                                 21


