                               SEQUENCE LISTING

<110> UNIVERSITY OF MASSACHUSETTS
      BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
 
<120> OPTIMIZED ANTI-FLT1 OLIGONUCLEOTIDE COMPOUNDS FOR TREATMENT OF
      PREECLAMPSIA AND OTHER ANGIOGENIC DISORDERS

<130> 727517-UM9-267PC

<140>PCT/US2022/034461
<141>2022-06-22

<150> 63/214,224
<151> 2021-06-23

<160> 26    

<170> PatentIn version 3.5

<210> 1
<211> 20
<212> DNA
<213> Homo sapiens

<400> 1
ctctcggatc tccaaattta                                                   20


<210> 2
<211> 20
<212> DNA
<213> Homo sapiens

<400> 2
catcatagct accatttatt                                                   20


<210> 3

<400> 3
000


<210> 4

<400> 4
000


<210> 5
<211> 114
<212> DNA
<213> Homo sapiens

<400> 5
gtgagcactg caacaaaaag gctgttttct ctcggatctc caaatttaaa agcacaagga       60

atgattgtac cacacaaagt aatgtaaaac attaaaggac tcattaaaaa gtaa            114


<210> 6
<211> 456
<212> DNA
<213> Homo sapiens

<400> 6
gaagaaagaa attacaatca gaggtgagca ctgcaacaaa aaggctgttt tctctcggat       60

ctccaaattt aaaagcacaa ggaatgattg taccacacaa agtaatgtaa aacattaaag      120

gactcattaa aaagtaacag ttgtctcata tcatcttgat ttattgtcac tgttgctaac      180

tttcaggctc ggaggagatg ctcctcccaa aatgagttcg gagatgatag cagtaataat      240

gagacccccg ggctccagct ctgggccccc cattcaggcc gagggggctg ctccgggggg      300

ccgacttggt gcacgtttgg atttggagga tccctgcact gccttctctg tgtttgttgc      360

tcttgctgtt ttctcctgcc tgataaacaa caacttggga tgatcctttc cattttgatg      420

ccaacctctt tttattttta agcggcgccc tatagt                                456


<210> 7
<211> 570
<212> DNA
<213> Homo sapiens

<400> 7
aactgtatac atcaacgtca ccatcgtcat cgtcatcatc accattgtca tcatcatcat       60

catcgtcatc atcatcatca tcatagctat catcattatc atcatcatca tcatcatcat      120

catagctacc atttattgaa aactattatg tgtcaacttc aaagaactta tcctttagtt      180

ggagagccaa gacaatcata acaataacaa atggccgggc atggtggctc acgcctgtaa      240

tcccagcact ttgggaggcc aaggcaggtg gatcatttga ggtcaggagt ccaagaccag      300

cctgaccaag atggtgaaat gctgtctcta ttaaaaatac aaaattagcc aggcatggtg      360

gctcatgcct gtaatgccag ctactcggga ggctgagaca ggagaatcac ttgaacccag      420

gaggcagagg ttgcagggag ccgagatcgt gtactgcact ccagcctggg caacaagagc      480

gaaactccgt ctcaaaaaac aaataaataa ataaataaat aaacagacaa aattcacttt      540

ttattctatt aaacttaaca tacatgctaa                                       570


<210> 8
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
uaaauuugga gauccgagag a                                                 21


<210> 9
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
cggaucucca aauuua                                                       16


<210> 10
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
uauaaauggu agcuaugaug a                                                 21


<210> 11
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
auagcuacca uuuaua                                                       16


<210> 12
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
uaaauuugga gauccgagag a                                                 21


<210> 13
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
cggaucucca aauuua                                                       16


<210> 14
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
uauaaauggu agcuaugaug a                                                 21


<210> 15
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
auagcuacca uuuaua                                                       16


<210> 16
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
uauaaauggu agcuaugaug a                                                 21


<210> 17
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
uaaauuugga gauccgagag a                                                 21


<210> 18
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 18
cggaucucca aauuuatt                                                     18


<210> 19
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
uauaaauggu agcuaugaug a                                                 21


<210> 20
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 20
auagcuacca uuuauatt                                                     18


<210> 21
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 21
cggaucucca aauuuatt                                                     18


<210> 22
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
uaaauuugga gauccgagag a                                                 21


<210> 23
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 23
auagcuacca uuuauatt                                                     18


<210> 24
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
uauaaauggu agcuaugaug a                                                 21


<210> 25
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
uauaaauggu agcuaugaug a                                                 21


<210> 26
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 26
auagcuacca uuuauatt                                                     18


