                               SEQUENCE LISTING

<110> FUJIFILM IRVINE SCIENTIFIC, INC.
 
<120> METHOD AND USE OF A TRANSGENIC MOUSE LINE

<130> 106556-0470

<140> PCT/US2022/034294
<141> 2022-06-21

<150> 63/213,335
<151> 2021-06-22

<160> 16    

<170> PatentIn version 3.5

<210> 1
<211> 351
<212> PRT
<213> Mus musculus

<400> 1
Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly Gly 
1               5                   10                  15      


Gly Asp Gly Ser Ala Gly Leu Glu Pro Gly Trp Val Asp Pro Arg Thr 
            20                  25                  30          


Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly Pro Gly 
        35                  40                  45              


Ser Glu Val Leu Gly Ile Ser Pro Cys Pro Pro Ala Tyr Glu Phe Cys 
    50                  55                  60                  


Gly Gly Met Ala Tyr Cys Gly Pro Gln Val Gly Leu Gly Leu Val Pro 
65                  70                  75                  80  


Gln Val Gly Val Glu Thr Leu Gln Pro Glu Gly Gln Ala Gly Ala Arg 
                85                  90                  95      


Val Glu Ser Asn Ser Glu Gly Thr Ser Ser Glu Pro Cys Ala Asp Arg 
            100                 105                 110         


Pro Asn Ala Val Lys Leu Glu Lys Val Glu Pro Thr Pro Glu Glu Ser 
        115                 120                 125             


Gln Asp Met Lys Ala Leu Gln Lys Glu Leu Glu Gln Phe Ala Lys Leu 
    130                 135                 140                 


Leu Lys Gln Lys Arg Ile Thr Leu Gly Tyr Thr Gln Ala Asp Val Gly 
145                 150                 155                 160 


Leu Thr Leu Gly Val Leu Phe Gly Lys Val Phe Ser Gln Thr Thr Ile 
                165                 170                 175     


Cys Arg Phe Glu Ala Leu Gln Leu Ser Leu Lys Asn Met Cys Lys Leu 
            180                 185                 190         


Arg Pro Leu Leu Glu Lys Trp Val Glu Glu Ala Asp Asn Asn Glu Asn 
        195                 200                 205             


Leu Gln Glu Ile Cys Lys Ser Glu Thr Leu Val Gln Ala Arg Lys Arg 
    210                 215                 220                 


Lys Arg Thr Ser Ile Glu Asn Arg Val Arg Trp Ser Leu Glu Thr Met 
225                 230                 235                 240 


Phe Leu Lys Cys Pro Lys Pro Ser Leu Gln Gln Ile Thr His Ile Ala 
                245                 250                 255     


Asn Gln Leu Gly Leu Glu Lys Asp Val Val Arg Val Trp Phe Cys Asn 
            260                 265                 270         


Arg Arg Gln Lys Gly Lys Arg Ser Ser Ile Glu Tyr Ser Gln Arg Glu 
        275                 280                 285             


Glu Tyr Glu Ala Thr Gly Thr Pro Phe Pro Gly Gly Ala Val Ser Phe 
    290                 295                 300                 


Pro Leu Pro Pro Gly Pro His Phe Gly Thr Pro Gly Tyr Gly Ser Pro 
305                 310                 315                 320 


His Phe Thr Thr Leu Tyr Ser Val Pro Phe Pro Glu Gly Glu Ala Phe 
                325                 330                 335     


Pro Ser Val Pro Val Thr Ala Leu Gly Ser Pro Met His Ser Asn 
            340                 345                 350     


<210> 2
<211> 239
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      GFP protein sequence

<400> 2
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210> 3
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210> 4
<211> 606
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Asp Gly Ser Ala Gly Leu Glu Pro Gly Trp Val Asp Pro Arg 
            20                  25                  30          


Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly Pro 
        35                  40                  45              


Gly Ser Glu Val Leu Gly Ile Ser Pro Cys Pro Pro Ala Tyr Glu Phe 
    50                  55                  60                  


Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val Gly Leu Gly Leu Val 
65                  70                  75                  80  


Pro Gln Val Gly Val Glu Thr Leu Gln Pro Glu Gly Gln Ala Gly Ala 
                85                  90                  95      


Arg Val Glu Ser Asn Ser Glu Gly Thr Ser Ser Glu Pro Cys Ala Asp 
            100                 105                 110         


Arg Pro Asn Ala Val Lys Leu Glu Lys Val Glu Pro Thr Pro Glu Glu 
        115                 120                 125             


Ser Gln Asp Met Lys Ala Leu Gln Lys Glu Leu Glu Gln Phe Ala Lys 
    130                 135                 140                 


Leu Leu Lys Gln Lys Arg Ile Thr Leu Gly Tyr Thr Gln Ala Asp Val 
145                 150                 155                 160 


Gly Leu Thr Leu Gly Val Leu Phe Gly Lys Val Phe Ser Gln Thr Thr 
                165                 170                 175     


Ile Cys Arg Phe Glu Ala Leu Gln Leu Ser Leu Lys Asn Met Cys Lys 
            180                 185                 190         


Leu Arg Pro Leu Leu Glu Lys Trp Val Glu Glu Ala Asp Asn Asn Glu 
        195                 200                 205             


Asn Leu Gln Glu Ile Cys Lys Ser Glu Thr Leu Val Gln Arg Lys Arg 
    210                 215                 220                 


Lys Arg Thr Ser Ile Glu Asn Arg Val Arg Trp Ser Leu Glu Thr Met 
225                 230                 235                 240 


Phe Leu Lys Cys Pro Lys Pro Ser Leu Gln Gln Ile Thr His Ile Ala 
                245                 250                 255     


Asn Gln Leu Gly Leu Glu Lys Asp Val Val Arg Val Trp Phe Cys Asn 
            260                 265                 270         


Arg Arg Gln Lys Gly Lys Arg Ser Ser Ile Glu Tyr Ser Gln Arg Glu 
        275                 280                 285             


Glu Tyr Glu Ala Thr Gly Thr Pro Phe Pro Gly Gly Ala Val Ser Phe 
    290                 295                 300                 


Pro Leu Pro Pro Gly Pro His Phe Gly Thr Pro Gly Tyr Gly Ser Pro 
305                 310                 315                 320 


His Phe Thr Thr Leu Tyr Ser Val Pro Phe Pro Glu Gly Glu Ala Phe 
                325                 330                 335     


Pro Ser Val Pro Val Thr Ala Leu Gly Ser Pro Met His Ser Asn Ser 
            340                 345                 350         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
        355                 360                 365             


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
    370                 375                 380                 


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
385                 390                 395                 400 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
                405                 410                 415     


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
            420                 425                 430         


Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
        435                 440                 445             


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
    450                 455                 460                 


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
465                 470                 475                 480 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
                485                 490                 495     


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
            500                 505                 510         


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
        515                 520                 525             


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
    530                 535                 540                 


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
545                 550                 555                 560 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu Ser 
                565                 570                 575     


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
            580                 585                 590         


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
        595                 600                 605     


<210> 5
<211> 19278
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
gggcctacta agtgttcact atgcagcagg ggctagcctg aactcccaga tagcattact       60

gttatatata aataatagca ttactgttat tttaaattta gtttgttatg tgtatgaggg      120

ttttgctttc ctgtgagcat gccctcaaag gtcagatgag ggcattggat cctctggaac      180

tgaagttcca aatgattgtg agccatccat cattcaggtg ctgagaactg agctcaggtc      240

ttctccaaga gcagcaggtg ctatttaaat tctctctcgc cgggcgtggt ggcgcacgtc      300

tttaatccca gcactctgga ggcagaggca ggaggatttc tgagttcgag gccagtcctc      360

tccctcttct tcttcttctt ttttttttcc gagacagggt ttctctgtgt agccctggct      420

gtcctggaac tcactctgta gaccaggctg gcctcgaact cagaaatttg cctgcctctg      480

cctcccaagt gctgggatta taaattcttt ttttttttta agatttattt atttattata      540

tataagtaca ctgtagttgt ctccagacgc accagaagag ggcgtcagat ctcattacgg      600

gtggttgtga gccaccatgt ggttgctggg atttgaactt cggacctttg gaagagcagt      660

cgggtgctct tacccactga gccatctcac cagcccctgg attataaatt cttatttgta      720

cagtttttgt tgttggtttt gtttgtttgt ttgtttcaac acttgggatt gaatccaggg      780

tcattggagt gtttggcctg ggttctgctg ctgagccaca ctccatatac ttgcatggat      840

tgtgtctttt attctatgtg gtggtggtgg tggtggtggt ggtggtggtg gtggtggtgg      900

tggtggtggt agagggaact cacccagccc acctcctctg gtttcactcc tccacacaca      960

cccttcatcc ctgtccttac cccctgccag taagaaactc cacaggatgt ctctctagga     1020

gtctgagaaa aaagcactaa gagaacaagc tgtttgtttt ttggggtttt ttttgggggg     1080

gtgggggggg gagttagaac tcaggaaatc agaacagggc taggtgtggt aatgaatgac     1140

atagatctag tcactcaaag gctgtgtacc tctgaagttg agactagcct ggtttatata     1200

aaaagtaacc tggtctatat aaaaaattct aagttacgcc gggcgatgat ggcacatgcc     1260

tttgatccta gcacttggga ggcagaggca ggcggatttc gaagtttgag gccagcctgg     1320

tctacaaagt gagttccagg acagccaggg ctacacagag aaaccctgcc ttgaaaacaa     1380

acaaacaaac aaacaaaaaa ccaaaaacaa ccaaaacaaa caaacaaaaa aaccccaaaa     1440

ccaaaacaaa acaaaacaaa aagttctaag ctatgtagaa ctcttggggc actcgtgatc     1500

aaagtctaag cattgaaaat ctctaaatgc caggcttggt ggcgcacgca cttaatacca     1560

gcacttggga ggcagaggca ggcagatttc tgagttcgag gccaacctgg tctacaaagt     1620

gagttccatg acagccaggg ctacacagag aaaccctgtc tcgaaagaca aaaaaaaaaa     1680

aaaaaaaaaa aaaaaaaaat ctctaaacaa gccctatcaa tcttcccttg ggggtatgga     1740

ctgttatctc ttcatcataa gaggaaagcg aataggtggt gtgaaggagg tctttggtgg     1800

tgcaggaggg agccactggc tgcaggggac acagggtaca gcatggctcc ttagttggac     1860

atctgcttga cagaatgagt gtctatctat ctgtggactt gggaatcaac cccaggtatt     1920

ccaggaggta agaagaacca ctctctgaac cagggtggtc ttttgagcca ccagaaaaaa     1980

catccaccat gtaattgtaa ccaagtaacc agtcataacc ccctgcaaca gcgcccagga     2040

gacttttgaa tctgaaacaa gcagaaccac agagaggggg aggaaaggtt atcctgaccc     2100

agagaggcaa atcctctctg gaaccccggg agctaggtca gatgctaagg gcatttgtgg     2160

ggagggctgg gagagaaggg ccctaggcta gcagcaggtc ctccttccct ttaacctctg     2220

gccatgttgg gtagggactc tccttgacaa acctgataac caggagttca tttccgagca     2280

cccacacagt ggaagaagct agcccatcgc ctaaagttgc ccttttgttc tctttttctc     2340

tctctcacac aaatttttaa attttattat ttatttattg acataatttc tctatgtatc     2400

ccaggctgtc tcagaactca ctttgtagac caggctggcc tcaaacttag agatgctcct     2460

acctctgcct cctgagtact aggattaagg atatccatca caacacctaa ctgtaataaa     2520

aatttcaatt tttttttctc tcttagcctc agctgcaatc acctctttta gccagtatac     2580

ctgcaggagc tccagtccat aggcgggctc tcctaatgcc tgaatttgac tctcaaagtg     2640

cattcacttc ctctcattac agctcttctg cagactcttt tatatcagga atctcaaaac     2700

ttgggttggg catggtactc gcctttaatc ccaggaggtg gaggccagcc tggtgtacaa     2760

agtgagttct aggtcaggca ggactgtaat gtctactcct tacatgaaca ggatagggcc     2820

tggcggggag agagggggga agctaggtgg gagtaagggt ggaaacgggc aatcgtgtca     2880

atggaagaag taaatgatca agacaatagg tctgttcaca gcattagaac cacccaaatg     2940

gtcatttggc atcggagtcc tctccctcct cccaatcccc ccccccattt gcttatctat     3000

ttatttttat tttatgtatg caagcatttt tcttttttct ttttctttct gggtttttcg     3060

agacagggtt tctctgtgta gccctggctg tcctggaact cactctgtag accaggctag     3120

cttcgaactc agaaatctgc ctgcctctgc ctcccaagtg ctggaatcaa aggcaagggc     3180

caccacacct ggcgcaagca tttttcaaag atgtatttgt ttatatatgt gagtacatta     3240

tctctctctt caggcacacc aggagagaga gagagagaga gagagagaga gagagagaga     3300

gagagagaga gagagagaga atcagatcct gtcacagatg gttgtgagtc accaagtggg     3360

agctgggatt tgaactcagg acctctggaa gagctgtcag tgcacttaac ctgtgagcca     3420

tctctccagt ccttttcctc tctgtttttt tttttttttt tttttttttt ttgacacagt     3480

ttaaccatgt agcttaggct aatcttcagt ttgctgtgcc tcagcttctg agtgtccact     3540

tgggattgca ggagtttgcc gccttgctca gcttacagct tgggatgctc ttctcacaga     3600

catccacgta ctagtactga aagacaaaga caaacaccgg tttgcttgca aactgctcaa     3660

gtcttgtcta gtttgattag gcttgagagg agaccttgcc agctttccca agaagactgt     3720

gtggaggttg gcggtagaag gtggggtaca gaagacttgc tttcatctca caaggtgccc     3780

cacccatctc tctaacgccc aatttttctt tacagaggca cagggacaac tccctacccc     3840

gacccatgtg gagtgagaag ggcaggagga tgcatgggaa tagggctgta gttttctttt     3900

caagttggaa gaaaatggag agttaggcca gggaaggtag tgacaccccc ctggggtgtc     3960

acacacacac acacacacac acacacacac acacacacat acacacacag ggaattctag     4020

cactggtggt gtgagcaagt aggtagctat atgtagtaat ataacaagat ttattttgct     4080

gagagtcatc acataaggtt cacactctaa gccagccagg tggtggtggt ggcacatgcc     4140

tttaatccca gcacttcgga gacagagaca ggaggatttc tgagttcgag gccagcctgg     4200

tctacaaagt gagttccagg atagccaggg ctacacagag aaaccctgtc tcgagagaaa     4260

aaaaaaaaaa aaaggttcac actctgtaaa ttcctaacta atgtctcatt cctgtctccc     4320

cacagctgct cacctatgtg acatatttta gcagaaggtc aggtccactc tcttaatctc     4380

ttaagagtgt ctgtgatttg agggacagga tcctagcggg gagactctcc acctacaagg     4440

cagatcaagg tggctggtta tcttgaatga gtgatgtcgt ggggttctgg ttatcagggg     4500

cagccttggg tgtagtggtg aagccatttc tgcaagtcta aaaggcattt ggacactgct     4560

catcagaact gggaaggcaa gaggatcaga agttcaaggg ccttcttggc tacgtagagt     4620

ttaggggcag cctctgctac atgtaaattt gtctcagaag aaaaaaggaa acgggcagta     4680

gtggcgaatg cctataatcc cagcacttgg gaagcagagg gcaggctgat ttctgagctc     4740

aaggccagcc tggtctacag agtgagttcc aggacagcca gggctacaca gagaaaccct     4800

gtctcagaaa gaaaaaaaaa aaaagggaga aatagaactc atttatttca aagggagcag     4860

gcacattccg caagccttct gttctgctgg tgacctattc ctaccttcag cttctagatc     4920

tttgtttttt cttttaattt ttattgtatt gtgtgtgtgt gtgtatctga gtgcaatatc     4980

aatatcgaac ctctggagat caaatgcttc tttgaaatgg accccaggga tcaaatccat     5040

ggtcgttagg ctcagcaagt gtggttactt gctgagctgt cctcaggttc ctctcaggcc     5100

tcccctcaag tctccccctc caaccccccc cccctcctgc cccctgcaag tctttttgat     5160

taggcaagaa aaccaagaca aggaaaggga gatgcagtta gctaaggaat ctatgccagc     5220

cagagaaact acctcctccc ttccagaaca tctggatttg ggaagagacg ttgctggtcc     5280

cagggcggct gggggttggg gttgggggag ggggatgcta accagcaagg aagctgttcc     5340

tggctggggc aggcctgact gagctcatgt cgctgaaact cctcatttct ccctatggct     5400

tcatagggag acccagcctg gatgctaaca cgagtgattt ccctgctcta gtctagtgtc     5460

ctccgtgagt ccatttaact gatcacccag tctgtgagga ggtggctgaa ctcacagtaa     5520

gaaagctgtg ggggtcaacg cctattgttt gtttgttttg ttttagacaa ggtctcctgc     5580

tgaggctggc tcaagctggc ctggaggact cttgtgttta aggctggcct taaattctct     5640

ttaaaagaaa atcatgtgta tatatgtgtg tccatgtaac tgcagatgac cacagcagcc     5700

aagagatttc tgttctccta gctgtaaacc acccaatatg ggtgctagga acagaatttt     5760

aaaagggtcc tctgaaagag caatgtacac tcaaatgctg agttctttcc cagcccctag     5820

ccttggacct ttgttcttat cacttccaac gcccaagggc aggcattata ggtgtggcat     5880

tccgcatctg gcttcccagg ataccttttc atgctggtgg accatctctg gctggggacg     5940

tgtgggcttc tctgctgtct ttggttctcc agacagaact ccgagacaga tcttgacttg     6000

gttctaaaat acaggtggtt tgtggcaagt taacgaattt tagctcaaat ttggggtatt     6060

taagatacca tggtgactct tttttgtttg tttttctttc tttctttttt ttttttaaaa     6120

agatttattt attattgtac gtaagtactt cagacaccag aagagggtga cagatttttt     6180

ttttttttcg agacaggatt tctctgtgaa gccctggctg tcctggaact cactctgtag     6240

accaggctgg cctggaactc agaaatccac ctgcctctgc ctcccaagtg ctgggattaa     6300

agccatgagt tgggaccgca cccggcccaa agtgactctt aaagggggca gagtggcaca     6360

tattttcaat cctagcactc aggaagcaaa ggctggtgga tctctgtgag ttcaaggcca     6420

gcctggtcta cagagtgagt tccaagccat ctaaggctat gtagggaacc cttgaatcaa     6480

acccaaaagt tagtctgatg attttctaag acccaggagg caagaaactg gatcagatga     6540

gccaacaggt ctgctgtccc atctccaggg ccaccaggct cacagctcgg gaccaggcta     6600

gggcacatct gtttcaagct agttctaaga agacttggga cttcagacaa agttgctgtt     6660

aaggactgta ttatactcta ggcacgctta gggctaacct ggttgcaaag ccagtcacta     6720

ggcagttaaa ggactcagaa tatgtctctt gtcctggcca gtgagtcacc aaaagagaaa     6780

tcacaatcca taagacaagg ttggtattga atacagacag gactgctggg ctgcaggcat     6840

acttgaactg tggtggagag tgctgtctag gccttagagg ctggccctgg gaggaactgg     6900

gtgtggggag gttgtagccc gaccctgccc ctccccccag ggaggttgag agttctgggc     6960

agacggcaga tgcataacaa aggtgcatga tagctctgcc ctgggggcag agaagatggt     7020

tggggagggg tccctctcgt cctagccctt ccttaatctg ctattgagga agctttgtga     7080

acttggcggc ttccaagtcg ctgcctttat ttaggtcttc caactaacct atggcactgt     7140

tccacaatga atgtatagaa attgggaggt gagcatgaca gagtggagga aacggaagat     7200

tcatggagag ggccagagag atggcccctc agccaccctg ggggatgact tggacccatg     7260

tggtagaagg aggggacttc cacacatgtg ctatgtgtag ctgtgtgtag gtacatacac     7320

acccttaaaa taaaacgcaa tttttttttc aaagtctcag ggtgaatttg gtgaagtcga     7380

tgaagctgag gcaggagaat tatcaggagt tcaagggcag cttgttttat agagaaaggt     7440

tccatctcta cctgatgaag actaccatca agagacaccc ccgcccccca gggcacctag     7500

agccactgac cctagccaac agctcaggcg ggctgggccc aggctcagaa ctctgtcctg     7560

gctatgtaca ctgtggggtg ctctgggctt tttgaggctg tgtgattcac cctggggcct     7620

tcgttcagag catggtgtag gagcagacag acaaacacca tcccttgcag acaggcactc     7680

tgagggctat tctcttgcaa agataactaa gcaccaggcc agtaatggga tcgtgaccca     7740

aggcaggggt gagaggacct tgaaggttga aaatgaaggc ctcctggggt cccgtcctaa     7800

gggttgtcct gtccagacgt ccccaacctc cgtctggaag acacaggcag atagcgctcg     7860

cctcagtttc tcccaccccc acagctctgc tcctccaccc acccaggggg cggggccaga     7920

ggtcaaggct agagggtggg attggggagg gagaggtgaa accgtcccta ggtgagccgt     7980

ctttccacca ggcccccggc tcggggtgcc caccttcccc atggctggac acctggcttc     8040

agacttcgcc ttctcacccc caccaggtgg gggtgatggg tcagcagggc tggagccggg     8100

ctgggtggat cctcgaacct ggctaagctt ccaagggcct ccaggtgggc ctggaatcgg     8160

accaggctca gaggtattgg ggatctcccc atgtccgccc gcatacgagt tctgcggagg     8220

gatggcatac tgtggacctc aggttggact gggcctagtc ccccaagttg gcgtggagac     8280

tttgcagcct gagggccagg caggagcacg agtggaaagc aactcagagg gaacctcctc     8340

tgagccctgt gccgaccgcc ccaatgccgt gaagttggag aaggtggaac caactcccga     8400

ggaggtaagt gaagggactt ggctgggctg gcagaggcag cagtgaaggg aattgggaac     8460

atgtagggta gccaccctgc ctgccaaagg tggtgatggc tgccgggcct cctgagaagc     8520

acgacgcagt gtggactaga acccagaatt gcaagaatca gaaaccggcc tggattgttt     8580

cggcctggcc cttgtcatgt aggtcaccta ggcctggcct gtgtcccgac acttgcttca     8640

tgccatcact gtctgtacac cagtgatgcg tgaaaatcag ccccccccca aaaaaaaaaa     8700

catatcagcc cctctgggga cttggatcac agtcggaccc aggaacttgg ccttaaggtt     8760

aggcatggct gggggggtaa aaaatggtgc ttatcctgga gttattgtta ctgaagaggt     8820

tgggtgtgac tggctgctga taggagctct tgtttgggcc atgtgtggag tagggctcac     8880

cttcagtcaa gtttacggcc tgtctacttt agcctcagac tccatgagtc acctttacac     8940

gagcagaccc ttgtagtgcc tgaggtgcag atctgatcga tttcagcctt tctacctttc     9000

cttgtaaaca agaaagggac acccttgggt aggggagttt tatctccagg ccatcttaag     9060

atcattctgt gagtgcacgg gccttgctta gtgtctgatg gcctacagcc agcactctgg     9120

agcaagtgta agcaattagc cttaagaaca aggtgcgagt ggataccgat gcccgccggg     9180

agttccgaca gcttagcgat tgttgtagca ggagtcccct ccctaagtgc cagtttctgt     9240

gttatctcag gtcctgtatg ccgccgggag tcccctagga aggcattaat agtttatctc     9300

acatcttaaa tggcccttaa tgaagcaaga gatttgaacc ttagttaagc taatcccaaa     9360

tcctcaaaat aggatttaga aaagccaaag acactgctga gggcgattac aagttttggt     9420

cttttgagga gcagttggag atgaaagtct gtctgaagcc gagagaatcc ttttccattg     9480

aaatggcatt gaggtgtgcc tcactggctg ctgcttctgt ctgtgccctg ggttggccag     9540

cctttgtgga gcacctcagc cctccatcct ggacctttgc tccaacaacc tgctcctctt     9600

ccgccctcaa ggctgacttg catctcccca gatgactgcc tccatttctg tcttctgtta     9660

gagacagaaa agcctgagaa accgacagcc attttggggg gggggggtcc ggttcacacg     9720

ctgcaactta gaaagcacac tcaactggcc atctgttata ccctccccac ctggtcccaa     9780

ccatcactgt gtactactga gaagaaggca gccttagcca caccctcgag tgcccctgcc     9840

gttctattgc tcatacatcg attgatatcc ctgtttcaac tttgaaaaaa aaaaattttt     9900

ttttttttgt ggtgtgtgca tgcctgctac tgtacacctg tgggcgtcag aggtggtcct     9960

ctgcaccctc cggccagtac cgcatccagg gtgagtcaga tgatttcctg tggtttgggc    10020

ctcaaggctt ctcacctcca gaggcttcta gcctgctgcc ttgctttctc tgtcgcactc    10080

tagtacagca ggagttttct tcgcactccg gagtgttgtc agctcctggg gcatggacat    10140

ttggctactt agagtgtgct gtgtaggttt tcatttagag ctgaacagag ggatggatct    10200

tattacccca gcccttgaga cactgaggca ggagagcttc ctagtgagtc cctgtttcaa    10260

tatcttcact aatactgtgt catactttgg gactttcttt cttcctttct ttcttttgat    10320

tttttttttt tttatatgag tacagtgtac ctgtcttcag acacacacca gaagagggca    10380

tcagatccta ctacagaagg ttgtgagcca ccttgtggtt gctgggaatt gaactccgga    10440

tctccggaag agaagtccgt ataccaactt ctgtattagt cagggttctc tagagtcaca    10500

gaacttatgg acagtctcta gatagtaaag gaatttattg atgacttaca gtcggcagcc    10560

caattcccaa caatggttca gtcgcagctg tgaatggaag tccaaggatc tagcagttac    10620

ttagtctcac gcagcaagca ggcgaaggag caagagctag agcttaactg ctgagccatg    10680

tgtttcttga gtaaagggat tacatgctcg ttcgtctggt caattctgca gccttaaaac    10740

ttcttcagaa tagggtgaca ttttgtcctc agtggggcgg ttttgagtaa tctgtgagca    10800

gataggaact tgctggggta ctgcacagaa ctctgggtag tgtggtactg tagatggcta    10860

ggttctgggg ggggaaagag ccatctatgt cacctaggaa tagagtgaat aacatttata    10920

taatcagacc agcccttgag gaggctgaga tcttttcatg gggcacccta gggtcacagt    10980

cccagctggt gtgactctga caagtctgcc tttctcacta cagtcccagg acatgaaagc    11040

cctgcagaag gagctagaac agtttgccaa gctgctgaag cagaagagga tcaccttggg    11100

gtacacccag gccgacgtgg ggctcaccct gggcgttctc tttggtgggt ctcccccagc    11160

atgttctgat ctcacggctc ttaatgtagg cgcaaggggg tggggcatct taggagctgc    11220

ttctccacag gtaagggagg attagacgct tgtagcttga actgtcagag gtgggggctt    11280

gggctccctt cttgctgcct cactcactct gtttgatcgg cctttcagga aaggtgttca    11340

gccagaccac catctgtcgc ttcgaggcct tgcagctcag ccttaagaac atgtgtaagc    11400

tgcggcccct gctggagaag tgggtggagg aagccgacaa caatgagaac cttcaggagg    11460

tgaggagtgg caggatgtgt gcaatgtctg ccaggcacag tcccttctgc tgcttccatt    11520

cctggcttga aactcctccc tctccaaccg gagctcgcag gagaagttct gtgtccttat    11580

tctgctgcta tgaattggaa tccagagcct taacatttgc taatcaatca ggctctctcc    11640

ttctgagtca ccctctgccc ccaccagcct gacaatggtc cctccccaga accccgtcta    11700

gtgctggtga aggctcagac ctaggtctac cagccccttc cagagcccct ttcagtaacc    11760

cctggctctg gggccacatc cagtcaatgc tcccttagca caatccctta gcggtttgtt    11820

cttcagtccc atctcaaggt ggggctgttg ccaagtcaaa tactaaagtt gctcttgtcg    11880

cccccatctt cccctgccca gatatgcaaa tcggagaccc tggtgcaggc ccggaagaga    11940

aagcgaacta gcattgagaa ccgtgtgagg tggagtctgg agaccatgtt tctgaagtgc    12000

ccgaagccct ccctacagca gatcactcac atcgccaatc agcttgggct agagaaggat    12060

gtgagtgcca agatcctgcc ctgtggtacc tggatgtttc cctgttccca ttccccaccc    12120

cccccacccc cccaccccca ccgccgccac cgctgactgc agcatcccag agcttatgat    12180

ctgatgtcca tctctgtgcc catcctaggt ggttcgagta tggttctgta accggcgcca    12240

gaagggcaaa agatcaagta ttgagtattc ccaacgagaa gagtatgagg ctacagggac    12300

acctttccca gggggggctg tatcctttcc tctgccccca ggtccccact ttggcacccc    12360

aggctatgga agcccccact tcaccacact ctactcagtc ccttttcctg agggcgaggc    12420

ctttccctct gttcccgtca ctgctctggg ctctcccatg cattcaaact ctggcggagg    12480

cgggagcggg gggggtggct ccggcggcgg agggagcatg gtgagcaagg gcgaggagct    12540

gttcaccggg gtggtgccca tcctggtcga gctggacggc gacgtaaacg gccacaagtt    12600

cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc aagctgaccc tgaagttcat    12660

ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc tgacctacgg    12720

cgtgcagtgc ttcagccgct accccgacca catgaagcag cacgacttct tcaagtccgc    12780

catgcccgaa ggctacgtcc aggagcgcac catcttcttc aaggacgacg gcaactacaa    12840

gacccgcgcc gaggtgaagt tcgagggcga caccctggtg aaccgcatcg agctgaaggg    12900

catcgacttc aaggaggacg gcaacatcct ggggcacaag ctggagtaca actacaacag    12960

ccacaacgtc tatatcatgg ccgacaagca gaagaacggc atcaaggtga acttcaagat    13020

ccgccacaac atcgaggacg gcagcgtgca gctcgccgac cactaccagc agaacacccc    13080

catcggcgac ggccccgtgc tgctgcccga caaccactac ctgagcaccc agtccaagct    13140

tagcaaagac cccaacgaga agcgcgatca catggtcctg ctggagttcg tgaccgccgc    13200

cgggatcact ctcggcatgg acgagctgta caagtaatga ggcaccagcc ctccctgggg    13260

atgctgtgag ccaaggcaag ggaggtagac aagagaacct ggagctttgg ggttaaattc    13320

ttttactgag gagggattaa aagcacaaca ggggtggggg gtgggatggg gaaagaagct    13380

cagtgatgct gttgatcagg agcctggcct gtctgtcact catcattttg ttcttaaata    13440

aagactggga cacacagtag atagctgaat tttgttttcc ttcagttcct agagagcctg    13500

cggttggaga aagccagtaa tggattctca aaccccaggt gatcttcaaa acaggcgcca    13560

ttgaaaccat tggagttcca caaaatgccc agggatagtt ggggttggag cccaacctat    13620

agaggaaggc attgcatatt cgccatccta gaggcggtaa gtctctgcta gctgatggac    13680

atcacctcat agccattgtc tggcagccgc cttctttcct cttgtcactc tgggagttct    13740

ggtgggctta tactttaaaa aaaagagttt ttttgggggg gttaagattt attttattta    13800

tatgggtaca ctgtagctgt cttctagaca caccagaaga gggcatggga tcccattaca    13860

gatggttgtg agccaccatg tggttgctgg gaattgaact caggacctct ggaagagcag    13920

tcagtgctct taaccgctga gccatctctc cagccctcaa actctttttt ttcttttcct    13980

tcaagatgag ttctgtgtag tcctggcgga ccaggttggc ctcagatcag cctgcctctg    14040

cctccgcagt gctgagatta aaggcccgtg ccactctagg ctaaattgtt atgcttctat    14100

tctagctgat gaccaccttt tttgggcgta gtagtgctgg gagtagggtc tgtacacatg    14160

tctacaatgc cagaataggt caaaggcttt agatctcaag gaactggatt tatagagagt    14220

tgggagcagc catgtaggtt ctgagaacca aacctgggtc ctctgcaaga agagccattg    14280

gctttttgtt tttgtttgtt ttgagacatt tctcggtgta gccctggcta tctggaactc    14340

tgtaggccag gctgtccctg aactcagatc cagtctatcc atccctgcct tccaagagct    14400

gggattaagg tcatgtacca ccacaggcca gctagccata gctcctaact gctgaaccat    14460

ttatttattt atttatttta tttttttggt ttttcgagac agggtttctc tgtatagctc    14520

tggatgtcct ggaactcact ttgtaaacca gtctggcctc gaactcagaa atctgcttgc    14580

ctctgcctcc ccagtgagtg ctgggatcaa atgcgtgcgc caccactccc agcttaagtc    14640

tttatttttt aaaatgttat ttattttggg gctggtgaga tggctcagtg gttaagagca    14700

ctgactgctc tgccagaggt cccgagttca aatcccagca actacatggt ggctcacaac    14760

catctgtaat gagatctgac gccctcttct ggtatgtctg aagacaacta cagtgtactt    14820

acatatatat ataataaata aattaaaaaa aaaaaagaga ggaggagcca agcagctcct    14880

ttagaaaaaa aaaaagttat ttattttatg tatttgagct gtcttcagac acaccagaag    14940

agggcaatgg atcccattac agatggttgt gagccaccat ggttgatggg aattgaactc    15000

tggacctctg gcagagcagt cagtgctctt aaccgctgag ccatctctcc agcccccaaa    15060

gccaagtctt aaagcatttt tgctgctgaa tgtcagccct accagatctc tgcctccctc    15120

ccctcccctc cccccagtat ctcatgaaga ccaagctggc ctggacacag taagtatgtg    15180

catatttatg tgtgaagatt gtcacaatgt gaggaaaaaa gttggttccc tccatggtgt    15240

gggtcctgtg ggtcaagtcc aggtcgctag gcttggcagc aagtgccttg actcatagtc    15300

ttctcctgcc caactccatg cttggtttcc acgagcccct gtgctatgga gaattccatc    15360

tccaggcctc accaaatcta atctccccat cctttgaaaa gcagacttag attcaacgca    15420

agtggatgaa acagtttatt ctttatttgg gaataaagac taagctctga aaagctagtc    15480

ccagagactc agctggtggt gatactagct agcggtggca tgaggatgcc ttgggaatgt    15540

gctctgggtc cttcagggtg ctttagccga tgccattcaa gaacatgagt agggttaggg    15600

tattgtggca gagcacttgc ctggtatatg ctggcttcag caaaataaaa ccataccttc    15660

taggaatggt ttctgggacc ggtgctctaa ctgcaggtat cctggcatcc atggaggcaa    15720

ggctttattc cttgtgactg ggcttgtagc tcactggaaa cttggaggct gcaacatctt    15780

tggcaggaaa ccatcttttc tgtcacttca tttgcaagca ttctccagcc ttgagtcagt    15840

ctttagcaat ggacctttcc ctgtggtcat tccctttgga gaaagacatt cctcaaagtc    15900

catggtaact ttgaatgagt gttttgcatg tacacatgcg tgagtgtgca tgcgctctca    15960

cacacgcacg cacatgcaca cgcgtgcaca cacacacaca cacacacaca cacacacaca    16020

cacacacaca ctgcttcagc ccttaggagc cattcttcta ttattatgtt tgagtgctct    16080

gcctgaatgt gcacctgcag gccagaagag ggcatcagat cccttttaga gatggtcaca    16140

agccatcatg ttgttgctgg aaattgggac ttctggaaga gcagccagtg tacccttaat    16200

tgctgagcca tcttactgcc caagatacat tcttacactg tgcctgaccc tgagccacat    16260

ctgtgtcctg actgcaaagt caagatgcca ttatggcatc ctggatgcta tagccagtgc    16320

aggccagagg gtaccagatg tcacagccat cacaccaacc caggctctgc tctctagcaa    16380

aaagaagctg gacaggactc cctaagggag tgagtgttcc tgagaaaccc tttgagtaac    16440

ttgcctctgg gtaactggta gccagaacag gaggctaaga ctgggatata ggaacttgga    16500

gattagggat gttaagtaga gcatacgcat agcacaaaag atacttggct ttggatatga    16560

gctgttgacg ccttcaatcc atcacaactc ccattctgaa tgctctatcc cgactacatg    16620

agggatttga ggctagcctg gattacacag tgagaccttg tattaaaaaa gagttgggtg    16680

tctcctccag agaggatctg ggtttgaacc tcagcaccta catagtggct agcaattatc    16740

cctccagttc ccagagaacc cagtgccctc ttctggcttc tgccggtatt gcatgcaagt    16800

gtgataccca atcatgcagg caaacaaagc agccttgaat tgacctgctc tcctctagtt    16860

ttgagacagt gttagtatgg ttttttatgt atagtgctgg gactccaaac atgggcaagt    16920

caggtgcttg ctaggcagtg ctcttctagt gagacatctc tttgttccct gtctcccaga    16980

ttgctttgta tagtctagtc ctaaccattg ttcccacata gtagcttgtc atgcatttat    17040

gggtgaaagc taacctgggt gtctgctgtg cccgtgcacc ccccttccct gccttctaag    17100

acctcagtct gaggctgttc aaagatctag aattcaaggt gctgacaggt gaccccactt    17160

acccactggc tatcagagca gctctggcga aaatgagacg ttggcgatcg cgtggcactt    17220

ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt    17280

atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta    17340

tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg    17400

tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac    17460

gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg    17520

aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc    17580

gtattgacgc cgggcaagag caactcggtc gccgcataca ctattctcag aatgacttgg    17640

ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat    17700

gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg    17760

gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg    17820

atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc    17880

ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt    17940

cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct    18000

cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc    18060

gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca    18120

cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct    18180

cactgattaa gcattggtaa tttgatatcg agctcgcttg gactcctgtt gatagatcca    18240

gtaatgacct cagaactcca tctggatttg ttcagaacgc tcggttgccg ccgggcgttt    18300

tttattggtg agaatccaag cactagtaac aacttatatc gtatggggct gacttcaggt    18360

gctacatttg aagagataaa ttgcactgaa atctagaaat attttatctg attaataaga    18420

tgatcttctt gagatcgttt tggtctgcgc gtaatctctt gctctgaaaa cgaaaaaacc    18480

gccttgcagg gcggtttttc gaaggttctc tgagctacca actctttgaa ccgaggtaac    18540

tggcttggag gagcgcagtc accaaaactt gtcctttcag tttagcctta accggcgcat    18600

gacttcaaga ctaactcctc taaatcaatt accagtggct gctgccagtg gtgcttttgc    18660

atgtctttcc gggttggact caagacgata gttaccggat aaggcgcagc ggtcggactg    18720

aacggggggt tcgtgcatac agtccagctt ggagcgaact gcctacccgg aactgagtgt    18780

caggcgtgga atgagacaaa cgcggccata acagcggaat gacaccggta aaccgaaagg    18840

caggaacagg agagcgcacg agggagccgc cagggggaaa cgcctggtat ctttatagtc    18900

ctgtcgggtt tcgccaccac tgatttgagc gtcagatttc gtgatgcttg tcaggggggc    18960

ggagcctatg gaaaaacggc tttgccgcgg ccctctcact tccctgttaa gtatcttcct    19020

ggcatcttcc aggaaatctc cgccccgttc gtaagccatt tccgctcgcc gcagtcgaac    19080

gaccgagcgt agcgagtcag tgagcgagga agcggaatat atccctaggt ataaacgcag    19140

aaaggcccac ccgaaggtga gccagtgtga ctctagtaga gagcgttcac cgacaaacaa    19200

cagataaaac gaaaggccca gtctttcgac tgagcctttc gttttatttg atgcgatcgc    19260

ctggagatcc ttactcga                                                  19278


<210> 6
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 6
atcttcttca aggacgacgg caac                                              24


<210> 7
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
tcctcgatgt tgtggcggat cttg                                              24


<210> 8
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 8
gagcttctgg tattagcgtt aggt                                              24


<210> 9
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 9
tccacaatga caaagacatg aggt                                              24


<210> 10
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 10
ccacatgaag cagcacgact t                                                 21


<210> 11
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 11
ggtgcgctcc tggacgta                                                     18


<210> 12
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 12
ttcaagtccg ccatgcccga a                                                 21


<210> 13
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 13
cacgtgggct ccagcatt                                                     18


<210> 14
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 14
tcaccagtca tttctgcctt tg                                                22


<210> 15
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 15
ccaatggtcg ggcactgctc aa                                                22


<210> 16
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> SITE
<222> (1)..(50) 
<223> This sequence may encompass 1-10 "Gly Gly Gly Gly Ser"
      repeating units

<400> 16
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser 
    50  


