                         SEQUENCE LISTING

<110>  The University of North Carolina at Chapel Hill
       PECOT, Chad
       CHAREDDY, Yogitha
 
<120>  INVERTED CHIMERIC siRNA MOLECULES AND METHODS OF USE THEREOF

<130>  5470.902.WO

<150>  US 63/212,976
<151>  2021-06-21

<160>  106   

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  1
gaggauaucu ggaagaaau                                                    19


<210>  2
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  2
gagaacaguu gaaacacaa                                                    19


<210>  3
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  3
aacacaaacu ugaacagcu                                                    19


<210>  4
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  4
aagaagauga ggaagaaau                                                    19


<210>  5
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  5
cacagcccac ugguccucaa ga                                                22


<210>  6
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  6
aagaggcgaa cacacaacgu c                                                 21


<210>  7
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  7
cagaucagca acaaccg                                                      17


<210>  8
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  8
gagaccuuca ucaaaaacau cauca                                             25


<210>  9
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  9
gagcuaaaac ggagcuuuu                                                    19


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  10
gaggauaucu ggaagaaaut t                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  11
gagaacaguu gaaacacaat t                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  12
aacacaaacu ugaacagcut t                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  13
aagaagauga ggaagaaaut t                                                 21


<210>  14
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  14
cacagcccac ugguccucaa gatt                                              24


<210>  15
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  15
aagaggcgaa cacacaacgu ctt                                               23


<210>  16
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  16
cagaucagca acaaccgtt                                                    19


<210>  17
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  17
gagaccuuca ucaaaaacau caucatt                                           27


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  18
gagcuaaaac ggagcuuuut t                                                 21


<210>  19
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  19
auuucuucca gauauccuc                                                    19


<210>  20
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  20
uuguguuuca acuguucuc                                                    19


<210>  21
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  21
agcuguucaa guuuguguu                                                    19


<210>  22
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  22
auuucuuccu caucuucuu                                                    19


<210>  23
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  23
ucuugaggac cagugggcug ug                                                22


<210>  24
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  24
gacguugugu guucgccucu u                                                 21


<210>  25
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  25
cgguuguugc ugaucug                                                      17


<210>  26
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  26
ugaugauguu uuugaugaag gucuc                                             25


<210>  27
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  27
aaaagcuccg uuuuagcuc                                                    19


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  28
auuucuucca gauauccuct t                                                 21


<210>  29
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  29
uuguguuuca acuguucuct t                                                 21


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  30
agcuguucaa guuuguguut t                                                 21


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  31
auuucuuccu caucuucuut t                                                 21


<210>  32
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  32
ucuugaggac cagugggcug ugtt                                              24


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  33
gacguugugu guucgccucu utt                                               23


<210>  34
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  34
cgguuguugc ugaucugtt                                                    19


<210>  35
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  35
ugaugauguu uuugaugaag gucuctt                                           27


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  36
aaaagcuccg uuuuagcuct t                                                 21


<210>  37
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2-Fluoroguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2-Fluoroguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-Fluorouridine

<400>  37
gcgaggauau cuggaagaaa u                                                 21


<210>  38
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methylguanosine

<400>  38
auuucuucca gauauccucg cug                                               23


<210>  39
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-Fluoroadenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-Fluoroadenosine

<400>  39
acgagaacag uugaaacaca a                                                 21


<210>  40
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methylguanosine

<400>  40
uuguguuuca acuguucucg ucg                                               23


<210>  41
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-Fluoroadenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-Fluorouridine

<400>  41
acaagaagau gaggaagaaa u                                                 21


<210>  42
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methylcytidine

<400>  42
auuucuuccu caucuucuug uuc                                               23


<210>  43
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-Fluoroadenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(10)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-Fluorocytidine

<400>  43
aagaggcgaa cacacaacgu c                                                 21


<210>  44
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluoroadenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (12)..(13)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyladenosine

<400>  44
gacguugugu guucgccucu uga                                               23


<210>  45
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-Fluoroguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-Fluorouridine

<400>  45
gagagcuaaa acggagcuuu u                                                 21


<210>  46
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluoroadenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (11)..(13)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyluridine

<400>  46
aaaagcuccg uuuuagcucu cgu                                               23


<210>  47
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyladenosine

<400>  47
gucucuugga uauucucga                                                    19


<210>  48
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluorocytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (11)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methylguanosine

<400>  48
ucgagaauau ccaagagaca g                                                 21


<210>  49
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (18)..(19)
<223>  2'-O-methyluridine

<400>  49
cagcuaauuc agaaucauu                                                    19


<210>  50
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluoroadenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (11)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<400>  50
aaugauucug aauuagcugu a                                                 21


<210>  51
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<400>  51
acgagaacag uugaaacaca a                                                 21


<210>  52
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methylguanosine

<400>  52
uuguguuuca acuguucucg ucg                                               23


<210>  53
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (15)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyluridine

<400>  53
acaagaagau gaggaagaaa u                                                 21


<210>  54
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (8)..(9)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(19)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methylcytidine

<400>  54
auuucuuccu caucuucuug uuc                                               23


<210>  55
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (17)..(18)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methylcytidine

<400>  55
gugguaguug gagcuguugg c                                                 21


<210>  56
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluorocytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (11)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (18)..(19)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyladenosine

<400>  56
gccaacagcu ccaacuacca caa                                               23


<210>  57
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(10)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(16)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<400>  57
uaacaauguu gcuuuucaaa a                                                 21


<210>  58
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (7)..(9)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (12)..(13)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyluridine

<400>  58
uuuugaaaag caacauuguu agu                                               23


<210>  59
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<400>  59
acuguacagu cuaaaauguc a                                                 21


<210>  60
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluoroguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (7)..(9)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methylguanosine

<400>  60
ugacauuuua gacuguacag ugg                                               23


<210>  61
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(16)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<400>  61
guaguuggag cuggggacgu a                                                 21


<210>  62
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (8)..(9)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(15)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (16)..(17)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyladenosine

<400>  62
uacgucacca gcuccaacua cca                                               23


<210>  63
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-Fluoroadenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-Fluorocytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  2'-Fluorocytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (28)..(28)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (36)..(37)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (42)..(42)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (43)..(43)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (44)..(44)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (46)..(46)
<223>  2'-O-methylguanosine

<400>  63
acgagaacag uugaaacaca attttucgag aauauccaag agacag                      46


<210>  64
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methylguanosine

<400>  64
uuguguuuca acuguucucg ucg                                               23


<210>  65
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyladenosine

<400>  65
gucucuugga uauucucga                                                    19


<210>  66
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (28)..(28)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  2'-Fluorocytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (38)..(39)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (42)..(42)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (43)..(43)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (44)..(44)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (45)..(45)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (46)..(46)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (47)..(47)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (48)..(48)
<223>  2'-O-methylguanosine

<400>  66
uuguguuuca acuguucucg ucgttttucg agaauaucca agagacag                    48


<210>  67
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-Fluoroadenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-Fluorocytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-Fluoroadenosine

<400>  67
acgagaacag uugaaacaca a                                                 21


<210>  68
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyladenosine

<400>  68
gucucuugga uauucucga                                                    19


<210>  69
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  2'-Fluorocytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (28)..(28)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (36)..(37)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (42)..(42)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (43)..(43)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (44)..(44)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (45)..(45)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (46)..(46)
<223>  2'-O-methylguanosine

<400>  69
acgagaacag uugaaacaca attttucgag aauauccaag agacag                      46


<210>  70
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methylguanosine

<400>  70
uuguguuuca acuguucucg ucg                                               23


<210>  71
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyladenosine

<400>  71
gucucuugga uauucucga                                                    19


<210>  72
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (28)..(28)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (30)..(31)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (33)..(34)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (42)..(42)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (43)..(43)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (44)..(44)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (45)..(45)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (46)..(46)
<223>  2'-O-methylguanosine

<400>  72
gucucuugga uauucucgat tttuuguguu ucaacuguuc ucgucg                      46


<210>  73
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluorocytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (11)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methylguanosine

<400>  73
ucgagaauau ccaagagaca g                                                 21


<210>  74
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<400>  74
acgagaacag uugaaacaca a                                                 21


<210>  75
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  2'-Fluorocytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (28)..(28)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (29)..(30)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (36)..(37)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (42)..(42)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (43)..(44)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (45)..(45)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (46)..(46)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (47)..(47)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (48)..(48)
<223>  2'-O-methyladenosine

<400>  75
acgagaacag uugaaacaaa attttgccaa cagcuccaac uaccacaa                    48


<210>  76
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methylguanosine

<400>  76
uuguguuuca acuguucucg ucg                                               23


<210>  77
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (17)..(18)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methylcytidine

<400>  77
gugguaguug gagcuguugg c                                                 21


<210>  78
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  2'-Fluoroadenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (28)..(28)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (29)..(30)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (33)..(34)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (42)..(43)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (44)..(44)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (45)..(45)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (46)..(46)
<223>  2'-O-methylcytidine

<400>  78
acgagaacag uugaaacaca attttuacgg caccagcucc aaauac                      46


<210>  79
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methylguanosine

<400>  79
uuguguuuca acuguucucg ucg                                               23


<210>  80
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyladenosine

<400>  80
aguuggagcu ggugacgua                                                    19


<210>  81
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  2'-Fluorocytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (28)..(28)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (34)..(35)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (42)..(42)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (43)..(43)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (44)..(44)
<223>  2'-O-methylguanosine

<400>  81
cagcuaauuc agaaucauut tttucgagaa uauccaagag acag                        44


<210>  82
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluoroadenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (11)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<400>  82
aaugauucug aauuagcugu a                                                 21


<210>  83
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyladenosine

<400>  83
gucucuugga uauucucga                                                    19


<210>  84
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (28)..(29)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (33)..(34)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (42)..(42)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (43)..(44)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (45)..(45)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (46)..(47)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (48)..(48)
<223>  2'-O-methylcytidine

<400>  84
acgagaacag uugaaacaca attttauuuc uuccucaucu ucuuguuc                    48


<210>  85
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methylguanosine

<400>  85
uuguguuuca acuguucucg ucg                                               23


<210>  86
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (15)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyluridine

<400>  86
acaagaagau gaggaagaaa u                                                 21


<210>  87
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (15)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (28)..(28)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (32)..(33)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (35)..(36)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (42)..(42)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (43)..(43)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (44)..(44)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (45)..(45)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (46)..(46)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (47)..(47)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (48)..(48)
<223>  2'-O-methylguanosine

<400>  87
acaagaagau gaggaagaaa uttttuugug uuucaacugu ucucgucg                    48


<210>  88
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (8)..(9)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(19)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methylcytidine

<400>  88
auuucuuccu caucuucuug uuc                                               23


<210>  89
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<400>  89
acgagaacag uugaaacaca a                                                 21


<210>  90
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (28)..(28)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (42)..(42)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (43)..(43)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (44)..(44)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (45)..(45)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (46)..(47)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (48)..(48)
<223>  2'-O-methylguanosine

<400>  90
acgagaacag uugaaacaca attttauuac uuagacauua cuagauug                    48


<210>  91
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Sythetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methylguanosine

<400>  91
uuguguuuca acuguucucg ucg                                               23


<210>  92
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (15)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyluridine

<400>  92
aucuaguaau gucuaaguaa u                                                 21


<210>  93
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(10)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(16)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  2'-Fluoroguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (28)..(28)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (32)..(34)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (42)..(42)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (43)..(43)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (44)..(44)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (45)..(45)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (46)..(46)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (47)..(47)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (48)..(48)
<223>  2'-O-methylguanosine

<400>  93
uaacaauguu gcuuuucaaa attttugaca uuuuagacug uacagugg                    48


<210>  94
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (7)..(9)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (12)..(13)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyluridine

<400>  94
uuuugaaaag caacauuguu agu                                               23


<210>  95
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<400>  95
acuguacagu cuaaaauguc a                                                 21


<210>  96
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (7)..(9)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (12)..(13)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (28)..(28)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  2'-Fluoroguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (42)..(42)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (43)..(43)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (44)..(44)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (45)..(45)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (46)..(46)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (47)..(47)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (48)..(48)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (49)..(49)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (50)..(50)
<223>  2'-O-methylguanosine

<400>  96
uuuugaaaag caacauuguu aguttttuga cauuuuagac uguacagugg                  50


<210>  97
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(10)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(16)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<400>  97
uaacaauguu gcuuuucaaa a                                                 21


<210>  98
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<400>  98
acuguacagu cuaaaauguc a                                                 21


<210>  99
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (28)..(29)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (32)..(34)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (37)..(38)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (42)..(42)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (43)..(43)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (44)..(45)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (46)..(46)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (47)..(47)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (48)..(48)
<223>  2'-O-methyluridine

<400>  99
acuguacagu cuaaaauguc attttuuuug aaaagcaaca uuguuagu                    48


<210>  100
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluoroguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (7)..(9)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methylguanosine

<400>  100
ugacauuuua gacuguacag ugg                                               23


<210>  101
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(10)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(16)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<400>  101
uaacaauguu gcuuuucaaa a                                                 21


<210>  102
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluoroguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (7)..(9)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (28)..(28)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  2'-Fluorouridine, phosphorothioate

<220>
<221>  modified_base
<222>  (30)..(31)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (39)..(40)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (42)..(42)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (43)..(43)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (44)..(44)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (45)..(45)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (46)..(47)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (48)..(48)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (49)..(49)
<223>  2'-O-methylguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (50)..(50)
<223>  2'-O-methyluridine

<400>  102
ugacauuuua gacuguacag uggttttuuu ugaaaagcaa cauuguuagu                  50


<210>  103
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<400>  103
acuguacagu cuaaaauguc a                                                 21


<210>  104
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(10)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(16)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2'-O-methyladenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyladenosine

<400>  104
uaacaauguu gcuuuucaaa a                                                 21


<210>  105
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-Fluoroguanosine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-Fluorouridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-Fluoroadenosine

<400>  105
guaguuggag cuguuggcgu a                                                 21


<210>  106
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine, phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-Fluoroadenosine, phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-Fluoroguanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-Fluorocytidine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-Fluoroadenosine

<220>
<221>  modified_base
<222>  (21)..(22)
<223>  2'-O-methylcytidine, phosphorothioate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyladenosine

<400>  106
uacgccaaca gcuccaacua cca                                               23


