                         SEQUENCE LISTING

<110>  Novartis AG
 
<120>  PYRAZOLYL DERIVATIVES AS INHIBITORS OF THE KRAS MUTANT PROTEIN

<130>  PAT059119-WO-PCT

<150>  US 63/214,009
<151>  2021-06-23

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  5128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
atgcgtccgg cgtagaggat cgagatcgat ctcgatcccg cgaaattaat acgactcact       60

ataggggaat tgtgagcgga taacaattcc cctctagaaa taattttgtt taactttaag      120

aaggagatat acatatgaaa acacatcatc atcatcatca tggtggcggc agtggcggtg      180

gctcaggcgg tggttctctc gaggttctgt tccagggtcc gggtttgaac gacatcttcg      240

aagctcagaa gatcgaatgg cacgagggtg gcggtagtgg tggtggctct atgactgaat      300

acaagctggt tgttgttggt gcttgtggcg ttggtaagag cgcactgacc atccagctca      360

ttcagaatca cttcgtggac gagtacgacc cgaccatcga agattcttac cgtaaacagg      420

tggttattga tggcgaaacc tgtctgctgg atattctgga cactgctggt caggaagagt      480

actccgctat gcgtgatcag tacatgcgta ctggtgaagg tttcctctgc gtgttcgcta      540

tcaacaacac caagtccttc gaagatatcc accattaccg tgaacagatc aaacgtgtga      600

aggacagcga agacgtgcca atggttctgg tgggcaacaa atgtgatctc ccgagccgta      660

ccgttgacac caaacaggca caagacctgg cacgttccta cggcatccca ttcattgaaa      720

ctagcgcgaa gactcgtcag ggtgtggacg acgcattcta cactctggtg cgtgaaattc      780

gcaagcacaa agagaaataa tggtaccgaa ttcgcggccg cctgcagcct aggctgctaa      840

acaaagcccg aaaggaagct gagttggctg ctgccaccgc tgagcaataa ctagcataac      900

cccttggggc ctctaaacgg gtcttgaggg gttttttgct gaaaggagga actatatccg      960

gattggcgaa tgggacgcgc cctgtagcgg cgcattaagt gcagcgtcaa aagggcgaca     1020

caaaatttat tctaaatgca taataaatac tgataacatc ttatagtttg tattatattt     1080

tgtattatcg ttgacatgta taattttgat atcaaaaact gattttccct ttattatttt     1140

cgagatttat tttcttaatt ctctttaaca aactagaaat attgtatata caaaaaatca     1200

taaataatag atgaatagtt taattatagg tgttcatcaa tcgaaaaagc aacgtatctt     1260

atttaaagtg cgttgctttt ttctcattta taaggttaaa taattctcat atatcaagca     1320

aagtgacagg cgcccttaaa tattctgaca aatgctcttt ccctaaactc cccccataaa     1380

aaaacccgcc gaagcgggtt tttacgttat ttgcggatta acgattactc gttatcagaa     1440

ccgcccaggg ggcccgagct taagactggc cgtcgtttta caacacagaa agagtttgta     1500

gaaacgcaaa aaggccatcc gtcaggggcc ttctgcttag tttgatgcct ggcagttccc     1560

tactctcgcc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     1620

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     1680

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     1740

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     1800

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     1860

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     1920

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     1980

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     2040

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     2100

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     2160

agtggtgggc taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga     2220

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     2280

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     2340

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgacgcg cgcgtaactc     2400

acgttaaggg attttggtca tgagcttgcg ccgtcccgtc aagtcagcgt aatgctctgc     2460

ttttagaaaa actcatcgag catcaaatga aactgcaatt tattcatatc aggattatca     2520

ataccatatt tttgaaaaag ccgtttctgt aatgaaggag aaaactcacc gaggcagttc     2580

cataggatgg caagatcctg gtatcggtct gcgattccga ctcgtccaac atcaatacaa     2640

cctattaatt tcccctcgtc aaaaataagg ttatcaagtg agaaatcacc atgagtgacg     2700

actgaatccg gtgagaatgg caaaagttta tgcatttctt tccagacttg ttcaacaggc     2760

cagccattac gctcgtcatc aaaatcactc gcatcaacca aaccgttatt cattcgtgat     2820

tgcgcctgag cgaggcgaaa tacgcgatcg ctgttaaaag gacaattaca aacaggaatc     2880

gagtgcaacc ggcgcaggaa cactgccagc gcatcaacaa tattttcacc tgaatcagga     2940

tattcttcta atacctggaa cgctgttttt ccggggatcg cagtggtgag taaccatgca     3000

tcatcaggag tacggataaa atgcttgatg gtcggaagtg gcataaattc cgtcagccag     3060

tttagtctga ccatctcatc tgtaacatca ttggcaacgc tacctttgcc atgtttcaga     3120

aacaactctg gcgcatcggg cttcccatac aagcgataga ttgtcgcacc tgattgcccg     3180

acattatcgc gagcccattt atacccatat aaatcagcat ccatgttgga atttaatcgc     3240

ggcctcgacg tttcccgttg aatatggctc atattcttcc tttttcaata ttattgaagc     3300

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa     3360

caaatagggg tcagtgttac aaccaattaa ccaattctga acattatcgc gagcccattt     3420

atacctgaat atggctcata acaccccttg tttgcctggc ggcagtagcg cggtggtccc     3480

acctgacccc atgccgaact cagaagtgaa acgccgtagc gccgatggta gtgtggggac     3540

tccccatgcg agagtaggga actgccaggc atcaaataaa acgaaaggct cagtcgaaag     3600

actgggcctt tcgcccgggc taattagggg gtgtcgccct tcgctgaaga attgatcccg     3660

gtgcctaatg agtgagctaa cttacattaa ttgcgttgcg ctcactgccc gctttccagt     3720

cgggaaacct gtcgtgccag ctgcattaat gaatcggcca acgcgcgggg agaggcggtt     3780

tgcgtattgg gcgccagggt ggtttttctt ttcaccagtg acacgggcaa cagctgattg     3840

cccttcaccg cctggccctg agagagttgc agcaagcggt ccacgctggt ttgccccagc     3900

aggcgaaaat cctgtttgat ggtggttaac ggcgggatat aacatgagct gtcttcggta     3960

tcgtcgtatc ccactaccga gatgtccgca ccaacgcgca gcccggactc ggtaatggcg     4020

cgcattgcgc ccagcgccat ctgatcgttg gcaaccagca tcgcagtggg aacgatgccc     4080

tcattcagca tttgcatggt ttgttgaaaa ccggacatgg cactccagtc gccttcccgt     4140

tccgctatcg gctgaatttg attgcgagtg agatatttat gccagccagc cagacgcaga     4200

cgcgccgaga cagaacttaa tgggcccgct aacagcgcga tttgctggtg acccaatgcg     4260

accagatgct ccacgcccag tcgcgtaccg tcttcatggg agaaaataat actgttgatg     4320

ggtgtctggt cagagacatc aagaaataac gccggaacat tagtgcaggc agcttccaca     4380

gcaatggcat cctggtcatc cagcggatag ttaatgatca gcccactgac gcgttgcgcg     4440

agaagattgt gcaccgccgc tttacaggct tcgacgccgc ttcgttctac catcgacacc     4500

accacgctgg cacccagttg atcggcgcga gatttaatcg ccgcgacaat ttgcgacggc     4560

gcgtgcaggg ccagactgga ggtggcaacg ccaatcagca acgactgttt gcccgccagt     4620

tgttgtgcca cgcggttggg aatgtaattc agctccgcca tcgccgcttc cactttttcc     4680

cgcgttttcg cagaaacgtg gctggcctgg ttcaccacgc gggaaacggt ctgataagag     4740

acaccggcat actctgcgac atcgtataac gttactggtt tcacattcac caccctgaat     4800

tgactctctt ccgggcgcta tcatgccata ccgcgaaagg ttttgcgcca ttcgatggtg     4860

tccgggatct cgacgctctc ccttatgcga ctcctgcatt aggaagcagc ccagtagtag     4920

gttgaggccg ttgagcaccg ccgccgcaag gaatggtgca tgcaaggaga tggcgcccaa     4980

cagtcccccg gccacggggc ctgccaccat acccacgccg aaacaagcgc tcatgagccc     5040

gaagtggcga gcccgatctt ccccatcggt gatgtcggcg atataggcgc cagcaaccgc     5100

acctgtggcg ccggtgatgc cggccacg                                        5128


