                         SEQUENCE LISTING

<110>  Oxford University Innovation Limited
 
<120>  POLYPEPTIDES AND USES THEREOF

<130>  N421908WO

<150>  GB 2109082.4
<151>  2021-06-24

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  619
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  1

Met Ala Asp Asn Gln Pro Val Pro Leu Thr Pro Ala Pro Pro Gly Met 
1               5                   10                  15      


Val Ser Leu Gly Val Asn Glu Asn Gly Glu Glu Glu Met Thr Val Ile 
            20                  25                  30          


Gly Gly Asp Gly Ser Gly Thr Gly Phe Ser Gly Asn Glu Ala Pro Ile 
        35                  40                  45              


Ile Pro Gly Ser Gly Ser Leu Gln Ala Asp Leu Gly Lys Lys Ser Leu 
    50                  55                  60                  


Thr Arg Leu Gln Ala Glu Ser Ser Ala Ala Ile His Ala Thr Ala Lys 
65                  70                  75                  80  


Trp Thr Thr Glu Asn Leu Ala Lys Thr Gln Ala Ala Gln Ala Glu Arg 
                85                  90                  95      


Ala Lys Ala Ala Met Leu Ser Gln Gln Ala Ala Lys Ala Lys Gln Ala 
            100                 105                 110         


Lys Leu Thr Gln His Leu Lys Asp Val Val Asp Arg Ala Leu Gln Asn 
        115                 120                 125             


Asn Lys Thr Arg Pro Thr Val Ile Asp Leu Ala His Gln Asn Asn Gln 
    130                 135                 140                 


Gln Met Ala Ala Met Ala Glu Phe Ile Gly Arg Gln Lys Ala Ile Glu 
145                 150                 155                 160 


Glu Ala Arg Lys Lys Ala Glu Arg Glu Ala Lys Arg Ala Glu Glu Ala 
                165                 170                 175     


Tyr Gln Ala Ala Leu Arg Ala Gln Glu Glu Glu Gln Arg Lys Gln Ala 
            180                 185                 190         


Glu Ile Glu Arg Lys Leu Gln Glu Ala Arg Lys Gln Glu Ala Ala Ala 
        195                 200                 205             


Lys Ala Lys Ala Glu Ala Asp Arg Ile Ala Ala Glu Lys Ala Glu Ala 
    210                 215                 220                 


Glu Ala Arg Ala Lys Ala Glu Ala Glu Arg Arg Lys Ala Glu Glu Ala 
225                 230                 235                 240 


Arg Lys Ala Leu Phe Ala Lys Ala Gly Ile Lys Asp Thr Pro Val Tyr 
                245                 250                 255     


Thr Leu Glu Met Thr Lys Ala Ala Thr Thr Leu Phe Leu Thr Pro Gly 
            260                 265                 270         


Val Arg Leu Leu Asn Arg Ala Pro Ala Met Ile Gln Leu Ser Ala Leu 
        275                 280                 285             


Ala Ala Glu Ile Asn Gly Val Leu Thr Thr Ala Ala Ser Ala Val Met 
    290                 295                 300                 


Thr Ala Thr Ala Glu Phe Ser Gly Trp Ile Ala Ser Ala Leu Trp Arg 
305                 310                 315                 320 


Gly Val Ala Gly Val Ala Thr Ala Ser Thr Val Gly Pro Met Val Ala 
                325                 330                 335     


Ala Ala Ser Thr Leu Phe Phe Ser Pro Arg Ala Gly Gly Gly Ser Asp 
            340                 345                 350         


Ser Lys Val Pro Gly Arg Asp Ile Glu Met Leu Ala Ala Gln Ala Arg 
        355                 360                 365             


Leu Phe Thr Ala Gly Lys Leu Ser Ile Glu Pro Gly Met Lys Ser Val 
    370                 375                 380                 


Asn Leu Pro Val Arg Gly Phe Ile Ser Ser Glu Thr Asp Gly Arg Gln 
385                 390                 395                 400 


Ser Leu Met Leu Val Lys Thr Gly Ser Asp Gly Val Pro Ser Thr Val 
                405                 410                 415     


Pro Val Leu Asp Ala Val Arg Asp Ser Thr Thr Gly Leu Asp Lys Ile 
            420                 425                 430         


Thr Val Pro Ala Met Ser Gly Ala Pro Ser Arg Thr Ile Leu Val Asn 
        435                 440                 445             


Pro Val Pro Ile Gly Pro Ala Ala Pro Trp His Thr Gly Asn Ser Gly 
    450                 455                 460                 


Pro Val Pro Val Thr Pro Val His Thr Gly Thr Glu Val Lys Gln Ala 
465                 470                 475                 480 


Asp Ser Ile Val Thr Thr Thr Leu Pro Ile Ala Asp Ile Pro Pro Leu 
                485                 490                 495     


Gln Asp Phe Ile Tyr Trp Gln Pro Asp Ala Ser Gly Thr Gly Val Glu 
            500                 505                 510         


Pro Ile Tyr Val Met Thr Ser Gln Pro Arg Lys Gly Val Lys Asp Tyr 
        515                 520                 525             


Gly His Asp Tyr His Pro Ala Pro Lys Thr Glu Glu Ile Lys Gly Leu 
    530                 535                 540                 


Gly Glu Leu Ile Glu Ser Arg Lys Lys Thr Pro Lys Gln Gly Gly Gly 
545                 550                 555                 560 


Gly Arg Arg Asp Arg Trp Val Gly Asp Lys Gly Arg Lys Ile Tyr Glu 
                565                 570                 575     


Trp Asp Ser Gln His Gly Glu Leu Glu Gly Tyr Arg Ala Ser Asp Gly 
            580                 585                 590         


Ser His Leu Gly Ala Phe Asp Pro Asn Thr Gly Lys Gln Leu Lys Gly 
        595                 600                 605             


Pro Asp Pro Lys Arg Asn Ile Lys Lys Tyr Leu 
    610                 615                 


<210>  2
<211>  42
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  2

Thr Val Ile Asp Leu Ala His Gln Asn Asn Gln Gln Met Ala Ala Met 
1               5                   10                  15      


Ala Glu Phe Ile Gly Arg Gln Lys Ala Ile Glu Glu Ala Arg Lys Lys 
            20                  25                  30          


Ala Glu Arg Glu Ala Lys Arg Ala Glu Glu 
        35                  40          


<210>  3
<211>  49
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  3

Thr Val Ile Asp Leu Ala His Gln Asn Asn Gln Gln Met Ala Ala Met 
1               5                   10                  15      


Ala Glu Phe Ile Gly Arg Gln Lys Ala Ile Glu Glu Ala Arg Lys Lys 
            20                  25                  30          


Ala Glu Arg Glu Ala Lys Arg Ala Glu Glu Ala Tyr Gln Ala Ala Leu 
        35                  40                  45              


Arg 
    


<210>  4
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KlebC134-182AEDANS

<400>  4

Met Thr Val Ile Asp Leu Ala His Gln Asn Asn Gln Gln Met Ala Ala 
1               5                   10                  15      


Met Ala Glu Phe Ile Gly Arg Gln Lys Ala Ile Glu Glu Ala Arg Lys 
            20                  25                  30          


Lys Ala Glu Arg Glu Ala Lys Arg Ala Glu Glu Ala Tyr Gln Ala Ala 
        35                  40                  45              


Leu Arg Glu Leu Asn Gly Gly Pro Cys Gly Ile Gly Val Ser Gly Gly 
    50                  55                  60                  


Glu Asn Leu Tyr Phe Gln 
65                  70  


<210>  5
<211>  486
<212>  PRT
<213>  Klebsiella quasipneumoniae

<400>  5

Met Lys Lys Leu Leu Pro Ile Leu Ile Gly Leu Ser Leu Thr Gly Phe 
1               5                   10                  15      


Ser Ala Met Ser Gln Ala Glu Asn Leu Leu Gln Val Tyr Gln Gln Ala 
            20                  25                  30          


Arg Ile Ser Asn Pro Asp Leu Arg Lys Ser Ala Ala Asp Arg Asp Ala 
        35                  40                  45              


Ala Phe Glu Lys Ile Asn Glu Ala Arg Ser Pro Leu Leu Pro Gln Leu 
    50                  55                  60                  


Gly Leu Gly Ala Asp Tyr Thr Tyr Thr Ser Gly Phe Arg Asp Tyr Lys 
65                  70                  75                  80  


Asp Gln Asn Ser Asn Val Thr Ser Gly Ser Leu Gln Leu Thr Gln Val 
                85                  90                  95      


Leu Phe Asp Met Ser Lys Trp Arg Ala Leu Thr Leu Gln Glu Lys Ala 
            100                 105                 110         


Ala Gly Ile Gln Asp Val Thr Tyr Gln Thr Asp Gln Gln Thr Leu Ile 
        115                 120                 125             


Leu Asn Thr Ala Thr Ala Tyr Phe Lys Val Leu Ala Ala Ile Asp Thr 
    130                 135                 140                 


Leu Ser Tyr Thr Glu Ala Gln Lys Gln Ala Ile Tyr Arg Gln Leu Asp 
145                 150                 155                 160 


Gln Thr Thr Gln Arg Phe Asn Val Gly Leu Val Ala Ile Thr Asp Val 
                165                 170                 175     


Gln Asn Ala Arg Ser Gln Tyr Asp Ala Val Leu Ala Asn Glu Val Thr 
            180                 185                 190         


Ala Arg Asn Asp Leu Asp Asn Ala Val Glu Glu Leu Arg Gln Val Thr 
        195                 200                 205             


Gly Asn Tyr Tyr Pro Glu Leu Ala Ser Leu Asn Val Asp Gly Phe Lys 
    210                 215                 220                 


Thr Ser Lys Pro Gln Ala Val Asn Ala Leu Leu Lys Glu Ala Glu Asn 
225                 230                 235                 240 


Arg Asn Leu Ser Leu Leu Gln Ala Arg Leu Asn Gln Asp Leu Ala Arg 
                245                 250                 255     


Glu Gln Ile Arg Gln Ala Gln Asp Gly His Leu Pro Thr Leu Asp Leu 
            260                 265                 270         


Asn Ala Ser Ser Gly Val Ser Asn Asn Arg Tyr Ser Gly Ser Lys Ser 
        275                 280                 285             


Ile Ser Gln Asp Ala Asp Ile Gly Gln Asn Lys Ile Gly Leu Ser Phe 
    290                 295                 300                 


Ser Leu Pro Leu Tyr Gln Gly Gly Met Val Asn Ser Gln Val Lys Gln 
305                 310                 315                 320 


Ala Gln Tyr Asn Phe Val Gly Ala Ser Glu Gln Leu Glu Ser Ala His 
                325                 330                 335     


Arg Ser Val Val Gln Thr Val Arg Ser Ser Phe Asn Asn Val Asn Ala 
            340                 345                 350         


Ser Ile Ser Ser Ile Asn Ala Tyr Lys Gln Ala Val Val Ser Ala Gln 
        355                 360                 365             


Ser Ser Leu Asp Ala Met Glu Ala Gly Tyr Ser Val Gly Thr Arg Thr 
    370                 375                 380                 


Ile Val Asp Val Leu Asp Ala Thr Thr Thr Leu Tyr Asn Ala Lys Gln 
385                 390                 395                 400 


Gln Leu Ser Asn Ala Arg Tyr Asn Tyr Leu Ile Asn Glu Leu Asn Ile 
                405                 410                 415     


Lys Ser Ala Leu Gly Thr Leu Asn Glu Gln Asp Leu Ile Ala Leu Asn 
            420                 425                 430         


Asn Thr Leu Gly Lys Pro Ile Ser Thr Ser Ala Asp Ser Val Ala Pro 
        435                 440                 445             


Glu Asn Pro Gln Gln Asp Ala Thr Ala Asp Gly Tyr Gly Asn Thr Thr 
    450                 455                 460                 


Ala Ala Met Lys Pro Ala Ser Ala Arg Thr Thr Thr His Ser Ser Gly 
465                 470                 475                 480 


Ser Asn Pro Phe Arg Gln 
                485     


<210>  6
<211>  464
<212>  PRT
<213>  Klebsiella quasipneumoniae

<400>  6

Glu Asn Leu Leu Gln Val Tyr Gln Gln Ala Arg Ile Ser Asn Pro Asp 
1               5                   10                  15      


Leu Arg Lys Ser Ala Ala Asp Arg Asp Ala Ala Phe Glu Lys Ile Asn 
            20                  25                  30          


Glu Ala Arg Ser Pro Leu Leu Pro Gln Leu Gly Leu Gly Ala Asp Tyr 
        35                  40                  45              


Thr Tyr Thr Ser Gly Phe Arg Asp Tyr Lys Asp Gln Asn Ser Asn Val 
    50                  55                  60                  


Thr Ser Gly Ser Leu Gln Leu Thr Gln Val Leu Phe Asp Met Ser Lys 
65                  70                  75                  80  


Trp Arg Ala Leu Thr Leu Gln Glu Lys Ala Ala Gly Ile Gln Asp Val 
                85                  90                  95      


Thr Tyr Gln Thr Asp Gln Gln Thr Leu Ile Leu Asn Thr Ala Thr Ala 
            100                 105                 110         


Tyr Phe Lys Val Leu Ala Ala Ile Asp Thr Leu Ser Tyr Thr Glu Ala 
        115                 120                 125             


Gln Lys Gln Ala Ile Tyr Arg Gln Leu Asp Gln Thr Thr Gln Arg Phe 
    130                 135                 140                 


Asn Val Gly Leu Val Ala Ile Thr Asp Val Gln Asn Ala Arg Ser Gln 
145                 150                 155                 160 


Tyr Asp Ala Val Leu Ala Asn Glu Val Thr Ala Arg Asn Asp Leu Asp 
                165                 170                 175     


Asn Ala Val Glu Glu Leu Arg Gln Val Thr Gly Asn Tyr Tyr Pro Glu 
            180                 185                 190         


Leu Ala Ser Leu Asn Val Asp Gly Phe Lys Thr Ser Lys Pro Gln Ala 
        195                 200                 205             


Val Asn Ala Leu Leu Lys Glu Ala Glu Asn Arg Asn Leu Ser Leu Leu 
    210                 215                 220                 


Gln Ala Arg Leu Asn Gln Asp Leu Ala Arg Glu Gln Ile Arg Gln Ala 
225                 230                 235                 240 


Gln Asp Gly His Leu Pro Thr Leu Asp Leu Asn Ala Ser Ser Gly Val 
                245                 250                 255     


Ser Asn Asn Arg Tyr Ser Gly Ser Lys Ser Ile Ser Gln Asp Ala Asp 
            260                 265                 270         


Ile Gly Gln Asn Lys Ile Gly Leu Ser Phe Ser Leu Pro Leu Tyr Gln 
        275                 280                 285             


Gly Gly Met Val Asn Ser Gln Val Lys Gln Ala Gln Tyr Asn Phe Val 
    290                 295                 300                 


Gly Ala Ser Glu Gln Leu Glu Ser Ala His Arg Ser Val Val Gln Thr 
305                 310                 315                 320 


Val Arg Ser Ser Phe Asn Asn Val Asn Ala Ser Ile Ser Ser Ile Asn 
                325                 330                 335     


Ala Tyr Lys Gln Ala Val Val Ser Ala Gln Ser Ser Leu Asp Ala Met 
            340                 345                 350         


Glu Ala Gly Tyr Ser Val Gly Thr Arg Thr Ile Val Asp Val Leu Asp 
        355                 360                 365             


Ala Thr Thr Thr Leu Tyr Asn Ala Lys Gln Gln Leu Ser Asn Ala Arg 
    370                 375                 380                 


Tyr Asn Tyr Leu Ile Asn Glu Leu Asn Ile Lys Ser Ala Leu Gly Thr 
385                 390                 395                 400 


Leu Asn Glu Gln Asp Leu Ile Ala Leu Asn Asn Thr Leu Gly Lys Pro 
                405                 410                 415     


Ile Ser Thr Ser Ala Asp Ser Val Ala Pro Glu Asn Pro Gln Gln Asp 
            420                 425                 430         


Ala Thr Ala Asp Gly Tyr Gly Asn Thr Thr Ala Ala Met Lys Pro Ala 
        435                 440                 445             


Ser Ala Arg Thr Thr Thr His Ser Ser Gly Ser Asn Pro Phe Arg Gln 
    450                 455                 460                 


<210>  7
<211>  153
<212>  DNA
<213>  Klebsiella pneumoniae

<400>  7
atgaccgtga tcgatttggc gcatcagaac aatcagcaaa tggcggctat ggcagagttt       60

atcggccgcc agaaagcgat tgaagaagct cgtaagaaag cagaacgcga agccaaacgt      120

gctgaagaag cgtatcaggc cgcgttgcgt taa                                   153


<210>  8
<211>  652
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hybrid KlebC-E9 DNase

<400>  8

Met Ala Asp Asn Gln Pro Val Pro Leu Thr Pro Ala Pro Pro Gly Met 
1               5                   10                  15      


Val Ser Leu Gly Val Asn Glu Asn Gly Glu Glu Glu Met Thr Val Ile 
            20                  25                  30          


Gly Gly Asp Gly Ser Gly Thr Gly Phe Ser Gly Asn Glu Ala Pro Ile 
        35                  40                  45              


Ile Pro Gly Ser Gly Ser Leu Gln Ala Asp Leu Gly Lys Lys Ser Leu 
    50                  55                  60                  


Thr Arg Leu Gln Ala Glu Ser Ser Ala Ala Ile His Ala Thr Ala Lys 
65                  70                  75                  80  


Trp Thr Thr Glu Asn Leu Ala Lys Thr Gln Ala Ala Gln Ala Glu Arg 
                85                  90                  95      


Ala Lys Ala Ala Met Leu Ser Gln Gln Ala Ala Lys Ala Lys Gln Ala 
            100                 105                 110         


Lys Leu Thr Gln His Leu Lys Asp Val Val Asp Arg Ala Leu Gln Asn 
        115                 120                 125             


Asn Lys Thr Arg Pro Thr Val Ile Asp Leu Ala His Gln Asn Asn Gln 
    130                 135                 140                 


Gln Met Ala Ala Met Ala Glu Phe Ile Gly Arg Gln Lys Ala Ile Glu 
145                 150                 155                 160 


Glu Ala Arg Lys Lys Ala Glu Arg Glu Ala Lys Arg Ala Glu Glu Ala 
                165                 170                 175     


Tyr Gln Ala Ala Leu Arg Ala Gln Glu Glu Glu Gln Arg Lys Gln Ala 
            180                 185                 190         


Glu Ile Glu Arg Lys Leu Gln Glu Ala Arg Lys Gln Glu Ala Ala Ala 
        195                 200                 205             


Lys Ala Lys Ala Glu Ala Asp Arg Ile Ala Ala Glu Lys Ala Glu Ala 
    210                 215                 220                 


Glu Ala Arg Ala Lys Ala Glu Ala Glu Arg Arg Lys Ala Glu Glu Ala 
225                 230                 235                 240 


Arg Lys Ala Leu Phe Ala Lys Ala Gly Ile Lys Asp Thr Pro Val Tyr 
                245                 250                 255     


Thr Leu Glu Met Thr Lys Ala Ala Thr Thr Leu Phe Leu Thr Pro Gly 
            260                 265                 270         


Val Arg Leu Leu Asn Arg Ala Pro Ala Met Ile Gln Leu Ser Ala Leu 
        275                 280                 285             


Ala Ala Glu Ile Asn Gly Val Leu Thr Thr Ala Ala Ser Ala Val Met 
    290                 295                 300                 


Thr Ala Thr Ala Glu Phe Ser Gly Trp Ile Ala Ser Ala Leu Trp Arg 
305                 310                 315                 320 


Gly Val Ala Gly Val Ala Thr Ala Ser Thr Val Gly Pro Met Val Ala 
                325                 330                 335     


Ala Ala Ser Thr Leu Phe Phe Ser Pro Arg Ala Gly Gly Gly Ser Asp 
            340                 345                 350         


Ser Lys Val Pro Gly Arg Asp Ile Glu Met Leu Ala Ala Gln Ala Arg 
        355                 360                 365             


Leu Phe Thr Ala Gly Lys Leu Ser Ile Glu Pro Gly Met Lys Ser Val 
    370                 375                 380                 


Asn Leu Pro Val Arg Gly Phe Ile Ser Ser Glu Thr Asp Gly Arg Gln 
385                 390                 395                 400 


Ser Leu Met Leu Val Lys Thr Gly Ser Asp Gly Val Pro Ser Thr Val 
                405                 410                 415     


Pro Val Leu Asp Ala Val Arg Asp Ser Thr Thr Gly Leu Asp Lys Ile 
            420                 425                 430         


Thr Val Pro Ala Met Ser Gly Ala Pro Ser Arg Thr Ile Leu Val Asn 
        435                 440                 445             


Pro Val Pro Ile Gly Pro Ala Ala Pro Trp His Thr Gly Asn Ser Gly 
    450                 455                 460                 


Pro Val Pro Val Thr Pro Val His Thr Gly Thr Glu Val Lys Gln Ala 
465                 470                 475                 480 


Asp Ser Ile Val Thr Thr Thr Leu Pro Ile Ala Asp Ile Pro Pro Leu 
                485                 490                 495     


Gln Asp Phe Ile Tyr Trp Gln Pro Asp Ala Ser Gly Thr Gly Val Glu 
            500                 505                 510         


Pro Ile Tyr Val Met Ala Met Glu Ser Lys Arg Asn Lys Pro Gly Lys 
        515                 520                 525             


Ala Thr Gly Lys Gly Lys Pro Val Gly Asp Lys Trp Leu Asp Asp Ala 
    530                 535                 540                 


Gly Lys Asp Ser Gly Ala Pro Ile Pro Asp Arg Ile Ala Asp Lys Leu 
545                 550                 555                 560 


Arg Asp Lys Glu Phe Lys Ser Phe Asp Asp Phe Arg Lys Ala Val Trp 
                565                 570                 575     


Glu Glu Val Ser Lys Asp Pro Glu Leu Ser Lys Asn Leu Asn Pro Ser 
            580                 585                 590         


Asn Lys Ser Ser Val Ser Lys Gly Tyr Ser Pro Phe Thr Pro Lys Asn 
        595                 600                 605             


Gln Gln Val Gly Gly Arg Lys Val Tyr Glu Leu His His Asp Lys Pro 
    610                 615                 620                 


Ile Ser Gln Gly Gly Glu Val Tyr Asp Met Asp Asn Ile Arg Val Thr 
625                 630                 635                 640 


Thr Pro Lys Arg His Ile Asp Ile His Arg Gly Lys 
                645                 650         


