               SEQUENCE LISTING

<110> Vestlandets Innovasjonsselskap AS (VIS)

<120> NAD-AUGMENTATION THERAPY FOR PARKINSON’S DISEASE

<130> 246 991 u22

<150> GR20220100277
<151> 2022-03-29
<150> GB2200884.1
<151> 2022-01-24
<150> GB 2109138.4
<151> 2021-06-24

<160> 11

<170> BiSSAP 1.3.6

<210> 1
<211> 140
<212> PRT
<213> Homo sapiens


<220> 
<223> SNCA (UniprotKB - P37840 (SYUA_HUMAN); HGNC: 11138, SNCA)

<400> 1
Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      
Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          
Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              
Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  
Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  
Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      
Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            100                 105                 110         
Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
        115                 120                 125             
Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
    130                 135                 140 

<210> 2
<211> 2527
<212> PRT
<213> Homo sapiens


<220> 
<223> LRRK2 (UniProtKB - Q5S007 (LRRK2_HUMAN); HGNC: 18618)

<400> 2
Met Ala Ser Gly Ser Cys Gln Gly Cys Glu Glu Asp Glu Glu Thr Leu 
1               5                   10                  15      
Lys Lys Leu Ile Val Arg Leu Asn Asn Val Gln Glu Gly Lys Gln Ile 
            20                  25                  30          
Glu Thr Leu Val Gln Ile Leu Glu Asp Leu Leu Val Phe Thr Tyr Ser 
        35                  40                  45              
Glu Arg Ala Ser Lys Leu Phe Gln Gly Lys Asn Ile His Val Pro Leu 
    50                  55                  60                  
Leu Ile Val Leu Asp Ser Tyr Met Arg Val Ala Ser Val Gln Gln Val 
65                  70                  75                  80  
Gly Trp Ser Leu Leu Cys Lys Leu Ile Glu Val Cys Pro Gly Thr Met 
                85                  90                  95      
Gln Ser Leu Met Gly Pro Gln Asp Val Gly Asn Asp Trp Glu Val Leu 
            100                 105                 110         
Gly Val His Gln Leu Ile Leu Lys Met Leu Thr Val His Asn Ala Ser 
        115                 120                 125             
Val Asn Leu Ser Val Ile Gly Leu Lys Thr Leu Asp Leu Leu Leu Thr 
    130                 135                 140                 
Ser Gly Lys Ile Thr Leu Leu Ile Leu Asp Glu Glu Ser Asp Ile Phe 
145                 150                 155                 160 
Met Leu Ile Phe Asp Ala Met His Ser Phe Pro Ala Asn Asp Glu Val 
                165                 170                 175     
Gln Lys Leu Gly Cys Lys Ala Leu His Val Leu Phe Glu Arg Val Ser 
            180                 185                 190         
Glu Glu Gln Leu Thr Glu Phe Val Glu Asn Lys Asp Tyr Met Ile Leu 
        195                 200                 205             
Leu Ser Ala Leu Thr Asn Phe Lys Asp Glu Glu Glu Ile Val Leu His 
    210                 215                 220                 
Val Leu His Cys Leu His Ser Leu Ala Ile Pro Cys Asn Asn Val Glu 
225                 230                 235                 240 
Val Leu Met Ser Gly Asn Val Arg Cys Tyr Asn Ile Val Val Glu Ala 
                245                 250                 255     
Met Lys Ala Phe Pro Met Ser Glu Arg Ile Gln Glu Val Ser Cys Cys 
            260                 265                 270         
Leu Leu His Arg Leu Thr Leu Gly Asn Phe Phe Asn Ile Leu Val Leu 
        275                 280                 285             
Asn Glu Val His Glu Phe Val Val Lys Ala Val Gln Gln Tyr Pro Glu 
    290                 295                 300                 
Asn Ala Ala Leu Gln Ile Ser Ala Leu Ser Cys Leu Ala Leu Leu Thr 
305                 310                 315                 320 
Glu Thr Ile Phe Leu Asn Gln Asp Leu Glu Glu Lys Asn Glu Asn Gln 
                325                 330                 335     
Glu Asn Asp Asp Glu Gly Glu Glu Asp Lys Leu Phe Trp Leu Glu Ala 
            340                 345                 350         
Cys Tyr Lys Ala Leu Thr Trp His Arg Lys Asn Lys His Val Gln Glu 
        355                 360                 365             
Ala Ala Cys Trp Ala Leu Asn Asn Leu Leu Met Tyr Gln Asn Ser Leu 
    370                 375                 380                 
His Glu Lys Ile Gly Asp Glu Asp Gly His Phe Pro Ala His Arg Glu 
385                 390                 395                 400 
Val Met Leu Ser Met Leu Met His Ser Ser Ser Lys Glu Val Phe Gln 
                405                 410                 415     
Ala Ser Ala Asn Ala Leu Ser Thr Leu Leu Glu Gln Asn Val Asn Phe 
            420                 425                 430         
Arg Lys Ile Leu Leu Ser Lys Gly Ile His Leu Asn Val Leu Glu Leu 
        435                 440                 445             
Met Gln Lys His Ile His Ser Pro Glu Val Ala Glu Ser Gly Cys Lys 
    450                 455                 460                 
Met Leu Asn His Leu Phe Glu Gly Ser Asn Thr Ser Leu Asp Ile Met 
465                 470                 475                 480 
Ala Ala Val Val Pro Lys Ile Leu Thr Val Met Lys Arg His Glu Thr 
                485                 490                 495     
Ser Leu Pro Val Gln Leu Glu Ala Leu Arg Ala Ile Leu His Phe Ile 
            500                 505                 510         
Val Pro Gly Met Pro Glu Glu Ser Arg Glu Asp Thr Glu Phe His His 
        515                 520                 525             
Lys Leu Asn Met Val Lys Lys Gln Cys Phe Lys Asn Asp Ile His Lys 
    530                 535                 540                 
Leu Val Leu Ala Ala Leu Asn Arg Phe Ile Gly Asn Pro Gly Ile Gln 
545                 550                 555                 560 
Lys Cys Gly Leu Lys Val Ile Ser Ser Ile Val His Phe Pro Asp Ala 
                565                 570                 575     
Leu Glu Met Leu Ser Leu Glu Gly Ala Met Asp Ser Val Leu His Thr 
            580                 585                 590         
Leu Gln Met Tyr Pro Asp Asp Gln Glu Ile Gln Cys Leu Gly Leu Ser 
        595                 600                 605             
Leu Ile Gly Tyr Leu Ile Thr Lys Lys Asn Val Phe Ile Gly Thr Gly 
    610                 615                 620                 
His Leu Leu Ala Lys Ile Leu Val Ser Ser Leu Tyr Arg Phe Lys Asp 
625                 630                 635                 640 
Val Ala Glu Ile Gln Thr Lys Gly Phe Gln Thr Ile Leu Ala Ile Leu 
                645                 650                 655     
Lys Leu Ser Ala Ser Phe Ser Lys Leu Leu Val His His Ser Phe Asp 
            660                 665                 670         
Leu Val Ile Phe His Gln Met Ser Ser Asn Ile Met Glu Gln Lys Asp 
        675                 680                 685             
Gln Gln Phe Leu Asn Leu Cys Cys Lys Cys Phe Ala Lys Val Ala Met 
    690                 695                 700                 
Asp Asp Tyr Leu Lys Asn Val Met Leu Glu Arg Ala Cys Asp Gln Asn 
705                 710                 715                 720 
Asn Ser Ile Met Val Glu Cys Leu Leu Leu Leu Gly Ala Asp Ala Asn 
                725                 730                 735     
Gln Ala Lys Glu Gly Ser Ser Leu Ile Cys Gln Val Cys Glu Lys Glu 
            740                 745                 750         
Ser Ser Pro Lys Leu Val Glu Leu Leu Leu Asn Ser Gly Ser Arg Glu 
        755                 760                 765             
Gln Asp Val Arg Lys Ala Leu Thr Ile Ser Ile Gly Lys Gly Asp Ser 
    770                 775                 780                 
Gln Ile Ile Ser Leu Leu Leu Arg Arg Leu Ala Leu Asp Val Ala Asn 
785                 790                 795                 800 
Asn Ser Ile Cys Leu Gly Gly Phe Cys Ile Gly Lys Val Glu Pro Ser 
                805                 810                 815     
Trp Leu Gly Pro Leu Phe Pro Asp Lys Thr Ser Asn Leu Arg Lys Gln 
            820                 825                 830         
Thr Asn Ile Ala Ser Thr Leu Ala Arg Met Val Ile Arg Tyr Gln Met 
        835                 840                 845             
Lys Ser Ala Val Glu Glu Gly Thr Ala Ser Gly Ser Asp Gly Asn Phe 
    850                 855                 860                 
Ser Glu Asp Val Leu Ser Lys Phe Asp Glu Trp Thr Phe Ile Pro Asp 
865                 870                 875                 880 
Ser Ser Met Asp Ser Val Phe Ala Gln Ser Asp Asp Leu Asp Ser Glu 
                885                 890                 895     
Gly Ser Glu Gly Ser Phe Leu Val Lys Lys Lys Ser Asn Ser Ile Ser 
            900                 905                 910         
Val Gly Glu Phe Tyr Arg Asp Ala Val Leu Gln Arg Cys Ser Pro Asn 
        915                 920                 925             
Leu Gln Arg His Ser Asn Ser Leu Gly Pro Ile Phe Asp His Glu Asp 
    930                 935                 940                 
Leu Leu Lys Arg Lys Arg Lys Ile Leu Ser Ser Asp Asp Ser Leu Arg 
945                 950                 955                 960 
Ser Ser Lys Leu Gln Ser His Met Arg His Ser Asp Ser Ile Ser Ser 
                965                 970                 975     
Leu Ala Ser Glu Arg Glu Tyr Ile Thr Ser Leu Asp Leu Ser Ala Asn 
            980                 985                 990         
Glu Leu Arg Asp Ile Asp Ala Leu Ser Gln Lys Cys Cys Ile Ser Val 
        995                 1000                1005            
His Leu Glu His Leu Glu Lys Leu Glu Leu His Gln Asn Ala Leu Thr 
    1010                1015                1020                
Ser Phe Pro Gln Gln Leu Cys Glu Thr Leu Lys Ser Leu Thr His Leu 
1025                1030                1035                1040
Asp Leu His Ser Asn Lys Phe Thr Ser Phe Pro Ser Tyr Leu Leu Lys 
                1045                1050                1055    
Met Ser Cys Ile Ala Asn Leu Asp Val Ser Arg Asn Asp Ile Gly Pro 
            1060                1065                1070        
Ser Val Val Leu Asp Pro Thr Val Lys Cys Pro Thr Leu Lys Gln Phe 
        1075                1080                1085            
Asn Leu Ser Tyr Asn Gln Leu Ser Phe Val Pro Glu Asn Leu Thr Asp 
    1090                1095                1100                
Val Val Glu Lys Leu Glu Gln Leu Ile Leu Glu Gly Asn Lys Ile Ser 
1105                1110                1115                1120
Gly Ile Cys Ser Pro Leu Arg Leu Lys Glu Leu Lys Ile Leu Asn Leu 
                1125                1130                1135    
Ser Lys Asn His Ile Ser Ser Leu Ser Glu Asn Phe Leu Glu Ala Cys 
            1140                1145                1150        
Pro Lys Val Glu Ser Phe Ser Ala Arg Met Asn Phe Leu Ala Ala Met 
        1155                1160                1165            
Pro Phe Leu Pro Pro Ser Met Thr Ile Leu Lys Leu Ser Gln Asn Lys 
    1170                1175                1180                
Phe Ser Cys Ile Pro Glu Ala Ile Leu Asn Leu Pro His Leu Arg Ser 
1185                1190                1195                1200
Leu Asp Met Ser Ser Asn Asp Ile Gln Tyr Leu Pro Gly Pro Ala His 
                1205                1210                1215    
Trp Lys Ser Leu Asn Leu Arg Glu Leu Leu Phe Ser His Asn Gln Ile 
            1220                1225                1230        
Ser Ile Leu Asp Leu Ser Glu Lys Ala Tyr Leu Trp Ser Arg Val Glu 
        1235                1240                1245            
Lys Leu His Leu Ser His Asn Lys Leu Lys Glu Ile Pro Pro Glu Ile 
    1250                1255                1260                
Gly Cys Leu Glu Asn Leu Thr Ser Leu Asp Val Ser Tyr Asn Leu Glu 
1265                1270                1275                1280
Leu Arg Ser Phe Pro Asn Glu Met Gly Lys Leu Ser Lys Ile Trp Asp 
                1285                1290                1295    
Leu Pro Leu Asp Glu Leu His Leu Asn Phe Asp Phe Lys His Ile Gly 
            1300                1305                1310        
Cys Lys Ala Lys Asp Ile Ile Arg Phe Leu Gln Gln Arg Leu Lys Lys 
        1315                1320                1325            
Ala Val Pro Tyr Asn Arg Met Lys Leu Met Ile Val Gly Asn Thr Gly 
    1330                1335                1340                
Ser Gly Lys Thr Thr Leu Leu Gln Gln Leu Met Lys Thr Lys Lys Ser 
1345                1350                1355                1360
Asp Leu Gly Met Gln Ser Ala Thr Val Gly Ile Asp Val Lys Asp Trp 
                1365                1370                1375    
Pro Ile Gln Ile Arg Asp Lys Arg Lys Arg Asp Leu Val Leu Asn Val 
            1380                1385                1390        
Trp Asp Phe Ala Gly Arg Glu Glu Phe Tyr Ser Thr His Pro His Phe 
        1395                1400                1405            
Met Thr Gln Arg Ala Leu Tyr Leu Ala Val Tyr Asp Leu Ser Lys Gly 
    1410                1415                1420                
Gln Ala Glu Val Asp Ala Met Lys Pro Trp Leu Phe Asn Ile Lys Ala 
1425                1430                1435                1440
Arg Ala Ser Ser Ser Pro Val Ile Leu Val Gly Thr His Leu Asp Val 
                1445                1450                1455    
Ser Asp Glu Lys Gln Arg Lys Ala Cys Met Ser Lys Ile Thr Lys Glu 
            1460                1465                1470        
Leu Leu Asn Lys Arg Gly Phe Pro Ala Ile Arg Asp Tyr His Phe Val 
        1475                1480                1485            
Asn Ala Thr Glu Glu Ser Asp Ala Leu Ala Lys Leu Arg Lys Thr Ile 
    1490                1495                1500                
Ile Asn Glu Ser Leu Asn Phe Lys Ile Arg Asp Gln Leu Val Val Gly 
1505                1510                1515                1520
Gln Leu Ile Pro Asp Cys Tyr Val Glu Leu Glu Lys Ile Ile Leu Ser 
                1525                1530                1535    
Glu Arg Lys Asn Val Pro Ile Glu Phe Pro Val Ile Asp Arg Lys Arg 
            1540                1545                1550        
Leu Leu Gln Leu Val Arg Glu Asn Gln Leu Gln Leu Asp Glu Asn Glu 
        1555                1560                1565            
Leu Pro His Ala Val His Phe Leu Asn Glu Ser Gly Val Leu Leu His 
    1570                1575                1580                
Phe Gln Asp Pro Ala Leu Gln Leu Ser Asp Leu Tyr Phe Val Glu Pro 
1585                1590                1595                1600
Lys Trp Leu Cys Lys Ile Met Ala Gln Ile Leu Thr Val Lys Val Glu 
                1605                1610                1615    
Gly Cys Pro Lys His Pro Lys Gly Ile Ile Ser Arg Arg Asp Val Glu 
            1620                1625                1630        
Lys Phe Leu Ser Lys Lys Arg Lys Phe Pro Lys Asn Tyr Met Ser Gln 
        1635                1640                1645            
Tyr Phe Lys Leu Leu Glu Lys Phe Gln Ile Ala Leu Pro Ile Gly Glu 
    1650                1655                1660                
Glu Tyr Leu Leu Val Pro Ser Ser Leu Ser Asp His Arg Pro Val Ile 
1665                1670                1675                1680
Glu Leu Pro His Cys Glu Asn Ser Glu Ile Ile Ile Arg Leu Tyr Glu 
                1685                1690                1695    
Met Pro Tyr Phe Pro Met Gly Phe Trp Ser Arg Leu Ile Asn Arg Leu 
            1700                1705                1710        
Leu Glu Ile Ser Pro Tyr Met Leu Ser Gly Arg Glu Arg Ala Leu Arg 
        1715                1720                1725            
Pro Asn Arg Met Tyr Trp Arg Gln Gly Ile Tyr Leu Asn Trp Ser Pro 
    1730                1735                1740                
Glu Ala Tyr Cys Leu Val Gly Ser Glu Val Leu Asp Asn His Pro Glu 
1745                1750                1755                1760
Ser Phe Leu Lys Ile Thr Val Pro Ser Cys Arg Lys Gly Cys Ile Leu 
                1765                1770                1775    
Leu Gly Gln Val Val Asp His Ile Asp Ser Leu Met Glu Glu Trp Phe 
            1780                1785                1790        
Pro Gly Leu Leu Glu Ile Asp Ile Cys Gly Glu Gly Glu Thr Leu Leu 
        1795                1800                1805            
Lys Lys Trp Ala Leu Tyr Ser Phe Asn Asp Gly Glu Glu His Gln Lys 
    1810                1815                1820                
Ile Leu Leu Asp Asp Leu Met Lys Lys Ala Glu Glu Gly Asp Leu Leu 
1825                1830                1835                1840
Val Asn Pro Asp Gln Pro Arg Leu Thr Ile Pro Ile Ser Gln Ile Ala 
                1845                1850                1855    
Pro Asp Leu Ile Leu Ala Asp Leu Pro Arg Asn Ile Met Leu Asn Asn 
            1860                1865                1870        
Asp Glu Leu Glu Phe Glu Gln Ala Pro Glu Phe Leu Leu Gly Asp Gly 
        1875                1880                1885            
Ser Phe Gly Ser Val Tyr Arg Ala Ala Tyr Glu Gly Glu Glu Val Ala 
    1890                1895                1900                
Val Lys Ile Phe Asn Lys His Thr Ser Leu Arg Leu Leu Arg Gln Glu 
1905                1910                1915                1920
Leu Val Val Leu Cys His Leu His His Pro Ser Leu Ile Ser Leu Leu 
                1925                1930                1935    
Ala Ala Gly Ile Arg Pro Arg Met Leu Val Met Glu Leu Ala Ser Lys 
            1940                1945                1950        
Gly Ser Leu Asp Arg Leu Leu Gln Gln Asp Lys Ala Ser Leu Thr Arg 
        1955                1960                1965            
Thr Leu Gln His Arg Ile Ala Leu His Val Ala Asp Gly Leu Arg Tyr 
    1970                1975                1980                
Leu His Ser Ala Met Ile Ile Tyr Arg Asp Leu Lys Pro His Asn Val 
1985                1990                1995                2000
Leu Leu Phe Thr Leu Tyr Pro Asn Ala Ala Ile Ile Ala Lys Ile Ala 
                2005                2010                2015    
Asp Tyr Gly Ile Ala Gln Tyr Cys Cys Arg Met Gly Ile Lys Thr Ser 
            2020                2025                2030        
Glu Gly Thr Pro Gly Phe Arg Ala Pro Glu Val Ala Arg Gly Asn Val 
        2035                2040                2045            
Ile Tyr Asn Gln Gln Ala Asp Val Tyr Ser Phe Gly Leu Leu Leu Tyr 
    2050                2055                2060                
Asp Ile Leu Thr Thr Gly Gly Arg Ile Val Glu Gly Leu Lys Phe Pro 
2065                2070                2075                2080
Asn Glu Phe Asp Glu Leu Glu Ile Gln Gly Lys Leu Pro Asp Pro Val 
                2085                2090                2095    
Lys Glu Tyr Gly Cys Ala Pro Trp Pro Met Val Glu Lys Leu Ile Lys 
            2100                2105                2110        
Gln Cys Leu Lys Glu Asn Pro Gln Glu Arg Pro Thr Ser Ala Gln Val 
        2115                2120                2125            
Phe Asp Ile Leu Asn Ser Ala Glu Leu Val Cys Leu Thr Arg Arg Ile 
    2130                2135                2140                
Leu Leu Pro Lys Asn Val Ile Val Glu Cys Met Val Ala Thr His His 
2145                2150                2155                2160
Asn Ser Arg Asn Ala Ser Ile Trp Leu Gly Cys Gly His Thr Asp Arg 
                2165                2170                2175    
Gly Gln Leu Ser Phe Leu Asp Leu Asn Thr Glu Gly Tyr Thr Ser Glu 
            2180                2185                2190        
Glu Val Ala Asp Ser Arg Ile Leu Cys Leu Ala Leu Val His Leu Pro 
        2195                2200                2205            
Val Glu Lys Glu Ser Trp Ile Val Ser Gly Thr Gln Ser Gly Thr Leu 
    2210                2215                2220                
Leu Val Ile Asn Thr Glu Asp Gly Lys Lys Arg His Thr Leu Glu Lys 
2225                2230                2235                2240
Met Thr Asp Ser Val Thr Cys Leu Tyr Cys Asn Ser Phe Ser Lys Gln 
                2245                2250                2255    
Ser Lys Gln Lys Asn Phe Leu Leu Val Gly Thr Ala Asp Gly Lys Leu 
            2260                2265                2270        
Ala Ile Phe Glu Asp Lys Thr Val Lys Leu Lys Gly Ala Ala Pro Leu 
        2275                2280                2285            
Lys Ile Leu Asn Ile Gly Asn Val Ser Thr Pro Leu Met Cys Leu Ser 
    2290                2295                2300                
Glu Ser Thr Asn Ser Thr Glu Arg Asn Val Met Trp Gly Gly Cys Gly 
2305                2310                2315                2320
Thr Lys Ile Phe Ser Phe Ser Asn Asp Phe Thr Ile Gln Lys Leu Ile 
                2325                2330                2335    
Glu Thr Arg Thr Ser Gln Leu Phe Ser Tyr Ala Ala Phe Ser Asp Ser 
            2340                2345                2350        
Asn Ile Ile Thr Val Val Val Asp Thr Ala Leu Tyr Ile Ala Lys Gln 
        2355                2360                2365            
Asn Ser Pro Val Val Glu Val Trp Asp Lys Lys Thr Glu Lys Leu Cys 
    2370                2375                2380                
Gly Leu Ile Asp Cys Val His Phe Leu Arg Glu Val Met Val Lys Glu 
2385                2390                2395                2400
Asn Lys Glu Ser Lys His Lys Met Ser Tyr Ser Gly Arg Val Lys Thr 
                2405                2410                2415    
Leu Cys Leu Gln Lys Asn Thr Ala Leu Trp Ile Gly Thr Gly Gly Gly 
            2420                2425                2430        
His Ile Leu Leu Leu Asp Leu Ser Thr Arg Arg Leu Ile Arg Val Ile 
        2435                2440                2445            
Tyr Asn Phe Cys Asn Ser Val Arg Val Met Met Thr Ala Gln Leu Gly 
    2450                2455                2460                
Ser Leu Lys Asn Val Met Leu Val Leu Gly Tyr Asn Arg Lys Asn Thr 
2465                2470                2475                2480
Glu Gly Thr Gln Lys Gln Lys Glu Ile Gln Ser Cys Leu Thr Val Trp 
                2485                2490                2495    
Asp Ile Asn Leu Pro His Glu Val Gln Asn Leu Glu Lys His Ile Glu 
            2500                2505                2510        
Val Arg Lys Glu Leu Ala Glu Lys Met Arg Arg Thr Ser Val Glu 
        2515                2520                2525        

<210> 3
<211> 796
<212> PRT
<213> Homo sapiens


<220> 
<223> VPS35 (UniProtKB - Q96QK1 (VPS35_HUMAN); HGNC:13487)

<400> 3
Met Pro Thr Thr Gln Gln Ser Pro Gln Asp Glu Gln Glu Lys Leu Leu 
1               5                   10                  15      
Asp Glu Ala Ile Gln Ala Val Lys Val Gln Ser Phe Gln Met Lys Arg 
            20                  25                  30          
Cys Leu Asp Lys Asn Lys Leu Met Asp Ala Leu Lys His Ala Ser Asn 
        35                  40                  45              
Met Leu Gly Glu Leu Arg Thr Ser Met Leu Ser Pro Lys Ser Tyr Tyr 
    50                  55                  60                  
Glu Leu Tyr Met Ala Ile Ser Asp Glu Leu His Tyr Leu Glu Val Tyr 
65                  70                  75                  80  
Leu Thr Asp Glu Phe Ala Lys Gly Arg Lys Val Ala Asp Leu Tyr Glu 
                85                  90                  95      
Leu Val Gln Tyr Ala Gly Asn Ile Ile Pro Arg Leu Tyr Leu Leu Ile 
            100                 105                 110         
Thr Val Gly Val Val Tyr Val Lys Ser Phe Pro Gln Ser Arg Lys Asp 
        115                 120                 125             
Ile Leu Lys Asp Leu Val Glu Met Cys Arg Gly Val Gln His Pro Leu 
    130                 135                 140                 
Arg Gly Leu Phe Leu Arg Asn Tyr Leu Leu Gln Cys Thr Arg Asn Ile 
145                 150                 155                 160 
Leu Pro Asp Glu Gly Glu Pro Thr Asp Glu Glu Thr Thr Gly Asp Ile 
                165                 170                 175     
Ser Asp Ser Met Asp Phe Val Leu Leu Asn Phe Ala Glu Met Asn Lys 
            180                 185                 190         
Leu Trp Val Arg Met Gln His Gln Gly His Ser Arg Asp Arg Glu Lys 
        195                 200                 205             
Arg Glu Arg Glu Arg Gln Glu Leu Arg Ile Leu Val Gly Thr Asn Leu 
    210                 215                 220                 
Val Arg Leu Ser Gln Leu Glu Gly Val Asn Val Glu Arg Tyr Lys Gln 
225                 230                 235                 240 
Ile Val Leu Thr Gly Ile Leu Glu Gln Val Val Asn Cys Arg Asp Ala 
                245                 250                 255     
Leu Ala Gln Glu Tyr Leu Met Glu Cys Ile Ile Gln Val Phe Pro Asp 
            260                 265                 270         
Glu Phe His Leu Gln Thr Leu Asn Pro Phe Leu Arg Ala Cys Ala Glu 
        275                 280                 285             
Leu His Gln Asn Val Asn Val Lys Asn Ile Ile Ile Ala Leu Ile Asp 
    290                 295                 300                 
Arg Leu Ala Leu Phe Ala His Arg Glu Asp Gly Pro Gly Ile Pro Ala 
305                 310                 315                 320 
Asp Ile Lys Leu Phe Asp Ile Phe Ser Gln Gln Val Ala Thr Val Ile 
                325                 330                 335     
Gln Ser Arg Gln Asp Met Pro Ser Glu Asp Val Val Ser Leu Gln Val 
            340                 345                 350         
Ser Leu Ile Asn Leu Ala Met Lys Cys Tyr Pro Asp Arg Val Asp Tyr 
        355                 360                 365             
Val Asp Lys Val Leu Glu Thr Thr Val Glu Ile Phe Asn Lys Leu Asn 
    370                 375                 380                 
Leu Glu His Ile Ala Thr Ser Ser Ala Val Ser Lys Glu Leu Thr Arg 
385                 390                 395                 400 
Leu Leu Lys Ile Pro Val Asp Thr Tyr Asn Asn Ile Leu Thr Val Leu 
                405                 410                 415     
Lys Leu Lys His Phe His Pro Leu Phe Glu Tyr Phe Asp Tyr Glu Ser 
            420                 425                 430         
Arg Lys Ser Met Ser Cys Tyr Val Leu Ser Asn Val Leu Asp Tyr Asn 
        435                 440                 445             
Thr Glu Ile Val Ser Gln Asp Gln Val Asp Ser Ile Met Asn Leu Val 
    450                 455                 460                 
Ser Thr Leu Ile Gln Asp Gln Pro Asp Gln Pro Val Glu Asp Pro Asp 
465                 470                 475                 480 
Pro Glu Asp Phe Ala Asp Glu Gln Ser Leu Val Gly Arg Phe Ile His 
                485                 490                 495     
Leu Leu Arg Ser Glu Asp Pro Asp Gln Gln Tyr Leu Ile Leu Asn Thr 
            500                 505                 510         
Ala Arg Lys His Phe Gly Ala Gly Gly Asn Gln Arg Ile Arg Phe Thr 
        515                 520                 525             
Leu Pro Pro Leu Val Phe Ala Ala Tyr Gln Leu Ala Phe Arg Tyr Lys 
    530                 535                 540                 
Glu Asn Ser Lys Val Asp Asp Lys Trp Glu Lys Lys Cys Gln Lys Ile 
545                 550                 555                 560 
Phe Ser Phe Ala His Gln Thr Ile Ser Ala Leu Ile Lys Ala Glu Leu 
                565                 570                 575     
Ala Glu Leu Pro Leu Arg Leu Phe Leu Gln Gly Ala Leu Ala Ala Gly 
            580                 585                 590         
Glu Ile Gly Phe Glu Asn His Glu Thr Val Ala Tyr Glu Phe Met Ser 
        595                 600                 605             
Gln Ala Phe Ser Leu Tyr Glu Asp Glu Ile Ser Asp Ser Lys Ala Gln 
    610                 615                 620                 
Leu Ala Ala Ile Thr Leu Ile Ile Gly Thr Phe Glu Arg Met Lys Cys 
625                 630                 635                 640 
Phe Ser Glu Glu Asn His Glu Pro Leu Arg Thr Gln Cys Ala Leu Ala 
                645                 650                 655     
Ala Ser Lys Leu Leu Lys Lys Pro Asp Gln Gly Arg Ala Val Ser Thr 
            660                 665                 670         
Cys Ala His Leu Phe Trp Ser Gly Arg Asn Thr Asp Lys Asn Gly Glu 
        675                 680                 685             
Glu Leu His Gly Gly Lys Arg Val Met Glu Cys Leu Lys Lys Ala Leu 
    690                 695                 700                 
Lys Ile Ala Asn Gln Cys Met Asp Pro Ser Leu Gln Val Gln Leu Phe 
705                 710                 715                 720 
Ile Glu Ile Leu Asn Arg Tyr Ile Tyr Phe Tyr Glu Lys Glu Asn Asp 
                725                 730                 735     
Ala Val Thr Ile Gln Val Leu Asn Gln Leu Ile Gln Lys Ile Arg Glu 
            740                 745                 750         
Asp Leu Pro Asn Leu Glu Ser Ser Glu Glu Thr Glu Gln Ile Asn Lys 
        755                 760                 765             
His Phe His Asn Thr Leu Glu His Leu Arg Leu Arg Arg Glu Ser Pro 
    770                 775                 780                 
Glu Ser Glu Gly Pro Ile Tyr Glu Gly Leu Ile Leu 
785                 790                 795     

<210> 4
<211> 796
<212> PRT
<213> Homo sapiens


<220> 
<223> PRKN (UniProtKB - O60260 (PRKN_HUMAN); HGNC:8607)

<400> 4
Met Pro Thr Thr Gln Gln Ser Pro Gln Asp Glu Gln Glu Lys Leu Leu 
1               5                   10                  15      
Asp Glu Ala Ile Gln Ala Val Lys Val Gln Ser Phe Gln Met Lys Arg 
            20                  25                  30          
Cys Leu Asp Lys Asn Lys Leu Met Asp Ala Leu Lys His Ala Ser Asn 
        35                  40                  45              
Met Leu Gly Glu Leu Arg Thr Ser Met Leu Ser Pro Lys Ser Tyr Tyr 
    50                  55                  60                  
Glu Leu Tyr Met Ala Ile Ser Asp Glu Leu His Tyr Leu Glu Val Tyr 
65                  70                  75                  80  
Leu Thr Asp Glu Phe Ala Lys Gly Arg Lys Val Ala Asp Leu Tyr Glu 
                85                  90                  95      
Leu Val Gln Tyr Ala Gly Asn Ile Ile Pro Arg Leu Tyr Leu Leu Ile 
            100                 105                 110         
Thr Val Gly Val Val Tyr Val Lys Ser Phe Pro Gln Ser Arg Lys Asp 
        115                 120                 125             
Ile Leu Lys Asp Leu Val Glu Met Cys Arg Gly Val Gln His Pro Leu 
    130                 135                 140                 
Arg Gly Leu Phe Leu Arg Asn Tyr Leu Leu Gln Cys Thr Arg Asn Ile 
145                 150                 155                 160 
Leu Pro Asp Glu Gly Glu Pro Thr Asp Glu Glu Thr Thr Gly Asp Ile 
                165                 170                 175     
Ser Asp Ser Met Asp Phe Val Leu Leu Asn Phe Ala Glu Met Asn Lys 
            180                 185                 190         
Leu Trp Val Arg Met Gln His Gln Gly His Ser Arg Asp Arg Glu Lys 
        195                 200                 205             
Arg Glu Arg Glu Arg Gln Glu Leu Arg Ile Leu Val Gly Thr Asn Leu 
    210                 215                 220                 
Val Arg Leu Ser Gln Leu Glu Gly Val Asn Val Glu Arg Tyr Lys Gln 
225                 230                 235                 240 
Ile Val Leu Thr Gly Ile Leu Glu Gln Val Val Asn Cys Arg Asp Ala 
                245                 250                 255     
Leu Ala Gln Glu Tyr Leu Met Glu Cys Ile Ile Gln Val Phe Pro Asp 
            260                 265                 270         
Glu Phe His Leu Gln Thr Leu Asn Pro Phe Leu Arg Ala Cys Ala Glu 
        275                 280                 285             
Leu His Gln Asn Val Asn Val Lys Asn Ile Ile Ile Ala Leu Ile Asp 
    290                 295                 300                 
Arg Leu Ala Leu Phe Ala His Arg Glu Asp Gly Pro Gly Ile Pro Ala 
305                 310                 315                 320 
Asp Ile Lys Leu Phe Asp Ile Phe Ser Gln Gln Val Ala Thr Val Ile 
                325                 330                 335     
Gln Ser Arg Gln Asp Met Pro Ser Glu Asp Val Val Ser Leu Gln Val 
            340                 345                 350         
Ser Leu Ile Asn Leu Ala Met Lys Cys Tyr Pro Asp Arg Val Asp Tyr 
        355                 360                 365             
Val Asp Lys Val Leu Glu Thr Thr Val Glu Ile Phe Asn Lys Leu Asn 
    370                 375                 380                 
Leu Glu His Ile Ala Thr Ser Ser Ala Val Ser Lys Glu Leu Thr Arg 
385                 390                 395                 400 
Leu Leu Lys Ile Pro Val Asp Thr Tyr Asn Asn Ile Leu Thr Val Leu 
                405                 410                 415     
Lys Leu Lys His Phe His Pro Leu Phe Glu Tyr Phe Asp Tyr Glu Ser 
            420                 425                 430         
Arg Lys Ser Met Ser Cys Tyr Val Leu Ser Asn Val Leu Asp Tyr Asn 
        435                 440                 445             
Thr Glu Ile Val Ser Gln Asp Gln Val Asp Ser Ile Met Asn Leu Val 
    450                 455                 460                 
Ser Thr Leu Ile Gln Asp Gln Pro Asp Gln Pro Val Glu Asp Pro Asp 
465                 470                 475                 480 
Pro Glu Asp Phe Ala Asp Glu Gln Ser Leu Val Gly Arg Phe Ile His 
                485                 490                 495     
Leu Leu Arg Ser Glu Asp Pro Asp Gln Gln Tyr Leu Ile Leu Asn Thr 
            500                 505                 510         
Ala Arg Lys His Phe Gly Ala Gly Gly Asn Gln Arg Ile Arg Phe Thr 
        515                 520                 525             
Leu Pro Pro Leu Val Phe Ala Ala Tyr Gln Leu Ala Phe Arg Tyr Lys 
    530                 535                 540                 
Glu Asn Ser Lys Val Asp Asp Lys Trp Glu Lys Lys Cys Gln Lys Ile 
545                 550                 555                 560 
Phe Ser Phe Ala His Gln Thr Ile Ser Ala Leu Ile Lys Ala Glu Leu 
                565                 570                 575     
Ala Glu Leu Pro Leu Arg Leu Phe Leu Gln Gly Ala Leu Ala Ala Gly 
            580                 585                 590         
Glu Ile Gly Phe Glu Asn His Glu Thr Val Ala Tyr Glu Phe Met Ser 
        595                 600                 605             
Gln Ala Phe Ser Leu Tyr Glu Asp Glu Ile Ser Asp Ser Lys Ala Gln 
    610                 615                 620                 
Leu Ala Ala Ile Thr Leu Ile Ile Gly Thr Phe Glu Arg Met Lys Cys 
625                 630                 635                 640 
Phe Ser Glu Glu Asn His Glu Pro Leu Arg Thr Gln Cys Ala Leu Ala 
                645                 650                 655     
Ala Ser Lys Leu Leu Lys Lys Pro Asp Gln Gly Arg Ala Val Ser Thr 
            660                 665                 670         
Cys Ala His Leu Phe Trp Ser Gly Arg Asn Thr Asp Lys Asn Gly Glu 
        675                 680                 685             
Glu Leu His Gly Gly Lys Arg Val Met Glu Cys Leu Lys Lys Ala Leu 
    690                 695                 700                 
Lys Ile Ala Asn Gln Cys Met Asp Pro Ser Leu Gln Val Gln Leu Phe 
705                 710                 715                 720 
Ile Glu Ile Leu Asn Arg Tyr Ile Tyr Phe Tyr Glu Lys Glu Asn Asp 
                725                 730                 735     
Ala Val Thr Ile Gln Val Leu Asn Gln Leu Ile Gln Lys Ile Arg Glu 
            740                 745                 750         
Asp Leu Pro Asn Leu Glu Ser Ser Glu Glu Thr Glu Gln Ile Asn Lys 
        755                 760                 765             
His Phe His Asn Thr Leu Glu His Leu Arg Leu Arg Arg Glu Ser Pro 
    770                 775                 780                 
Glu Ser Glu Gly Pro Ile Tyr Glu Gly Leu Ile Leu 
785                 790                 795     

<210> 5
<211> 581
<212> PRT
<213> Homo sapiens


<220> 
<223> PINK1 (UniProtKB - Q9BXM7 (PINK1_HUMAN); HGNC:14581)

<400> 5
Met Ala Val Arg Gln Ala Leu Gly Arg Gly Leu Gln Leu Gly Arg Ala 
1               5                   10                  15      
Leu Leu Leu Arg Phe Thr Gly Lys Pro Gly Arg Ala Tyr Gly Leu Gly 
            20                  25                  30          
Arg Pro Gly Pro Ala Ala Gly Cys Val Arg Gly Glu Arg Pro Gly Trp 
        35                  40                  45              
Ala Ala Gly Pro Gly Ala Glu Pro Arg Arg Val Gly Leu Gly Leu Pro 
    50                  55                  60                  
Asn Arg Leu Arg Phe Phe Arg Gln Ser Val Ala Gly Leu Ala Ala Arg 
65                  70                  75                  80  
Leu Gln Arg Gln Phe Val Val Arg Ala Trp Gly Cys Ala Gly Pro Cys 
                85                  90                  95      
Gly Arg Ala Val Phe Leu Ala Phe Gly Leu Gly Leu Gly Leu Ile Glu 
            100                 105                 110         
Glu Lys Gln Ala Glu Ser Arg Arg Ala Val Ser Ala Cys Gln Glu Ile 
        115                 120                 125             
Gln Ala Ile Phe Thr Gln Lys Ser Lys Pro Gly Pro Asp Pro Leu Asp 
    130                 135                 140                 
Thr Arg Arg Leu Gln Gly Phe Arg Leu Glu Glu Tyr Leu Ile Gly Gln 
145                 150                 155                 160 
Ser Ile Gly Lys Gly Cys Ser Ala Ala Val Tyr Glu Ala Thr Met Pro 
                165                 170                 175     
Thr Leu Pro Gln Asn Leu Glu Val Thr Lys Ser Thr Gly Leu Leu Pro 
            180                 185                 190         
Gly Arg Gly Pro Gly Thr Ser Ala Pro Gly Glu Gly Gln Glu Arg Ala 
        195                 200                 205             
Pro Gly Ala Pro Ala Phe Pro Leu Ala Ile Lys Met Met Trp Asn Ile 
    210                 215                 220                 
Ser Ala Gly Ser Ser Ser Glu Ala Ile Leu Asn Thr Met Ser Gln Glu 
225                 230                 235                 240 
Leu Val Pro Ala Ser Arg Val Ala Leu Ala Gly Glu Tyr Gly Ala Val 
                245                 250                 255     
Thr Tyr Arg Lys Ser Lys Arg Gly Pro Lys Gln Leu Ala Pro His Pro 
            260                 265                 270         
Asn Ile Ile Arg Val Leu Arg Ala Phe Thr Ser Ser Val Pro Leu Leu 
        275                 280                 285             
Pro Gly Ala Leu Val Asp Tyr Pro Asp Val Leu Pro Ser Arg Leu His 
    290                 295                 300                 
Pro Glu Gly Leu Gly His Gly Arg Thr Leu Phe Leu Val Met Lys Asn 
305                 310                 315                 320 
Tyr Pro Cys Thr Leu Arg Gln Tyr Leu Cys Val Asn Thr Pro Ser Pro 
                325                 330                 335     
Arg Leu Ala Ala Met Met Leu Leu Gln Leu Leu Glu Gly Val Asp His 
            340                 345                 350         
Leu Val Gln Gln Gly Ile Ala His Arg Asp Leu Lys Ser Asp Asn Ile 
        355                 360                 365             
Leu Val Glu Leu Asp Pro Asp Gly Cys Pro Trp Leu Val Ile Ala Asp 
    370                 375                 380                 
Phe Gly Cys Cys Leu Ala Asp Glu Ser Ile Gly Leu Gln Leu Pro Phe 
385                 390                 395                 400 
Ser Ser Trp Tyr Val Asp Arg Gly Gly Asn Gly Cys Leu Met Ala Pro 
                405                 410                 415     
Glu Val Ser Thr Ala Arg Pro Gly Pro Arg Ala Val Ile Asp Tyr Ser 
            420                 425                 430         
Lys Ala Asp Ala Trp Ala Val Gly Ala Ile Ala Tyr Glu Ile Phe Gly 
        435                 440                 445             
Leu Val Asn Pro Phe Tyr Gly Gln Gly Lys Ala His Leu Glu Ser Arg 
    450                 455                 460                 
Ser Tyr Gln Glu Ala Gln Leu Pro Ala Leu Pro Glu Ser Val Pro Pro 
465                 470                 475                 480 
Asp Val Arg Gln Leu Val Arg Ala Leu Leu Gln Arg Glu Ala Ser Lys 
                485                 490                 495     
Arg Pro Ser Ala Arg Val Ala Ala Asn Val Leu His Leu Ser Leu Trp 
            500                 505                 510         
Gly Glu His Ile Leu Ala Leu Lys Asn Leu Lys Leu Asp Lys Met Val 
        515                 520                 525             
Gly Trp Leu Leu Gln Gln Ser Ala Ala Thr Leu Leu Ala Asn Arg Leu 
    530                 535                 540                 
Thr Glu Lys Cys Cys Val Glu Thr Lys Met Lys Met Leu Phe Leu Ala 
545                 550                 555                 560 
Asn Leu Glu Cys Glu Thr Leu Cys Gln Ala Ala Leu Leu Leu Cys Ser 
                565                 570                 575     
Trp Arg Ala Ala Leu 
            580     

<210> 6
<211> 3177
<212> DNA
<213> Homo sapiens


<220> 
<223> SNCA (cDNA - NCBI Reference Sequence: NM_000345.4)

<400> 6
ggcgacgacc agaaggggcc caagagaggg ggcgagcgac cgagcgccgc gacgcggaag       60

tgaggtgcgt gcgggctgca gcgcagaccc cggcccggcc cctccgagag cgtcctgggc      120

gctccctcac gccttgcctt caagccttct gcctttccac cctcgtgagc ggagaactgg      180

gagtggccat tcgacgacag tgtggtgtaa aggaattcat tagccatgga tgtattcatg      240

aaaggacttt caaaggccaa ggagggagtt gtggctgctg ctgagaaaac caaacagggt      300

gtggcagaag cagcaggaaa gacaaaagag ggtgttctct atgtaggctc caaaaccaag      360

gagggagtgg tgcatggtgt ggcaacagtg gctgagaaga ccaaagagca agtgacaaat      420

gttggaggag cagtggtgac gggtgtgaca gcagtagccc agaagacagt ggagggagca      480

gggagcattg cagcagccac tggctttgtc aaaaaggacc agttgggcaa gaatgaagaa      540

ggagccccac aggaaggaat tctggaagat atgcctgtgg atcctgacaa tgaggcttat      600

gaaatgcctt ctgaggaagg gtatcaagac tacgaacctg aagcctaaga aatatctttg      660

ctcccagttt cttgagatct gctgacagat gttccatcct gtacaagtgc tcagttccaa      720

tgtgcccagt catgacattt ctcaaagttt ttacagtgta tctcgaagtc ttccatcagc      780

agtgattgaa gtatctgtac ctgcccccac tcagcatttc ggtgcttccc tttcactgaa      840

gtgaatacat ggtagcaggg tctttgtgtg ctgtggattt tgtggcttca atctacgatg      900

ttaaaacaaa ttaaaaacac ctaagtgact accacttatt tctaaatcct cactattttt      960

ttgttgctgt tgttcagaag ttgttagtga tttgctatca tatattataa gatttttagg     1020

tgtcttttaa tgatactgtc taagaataat gacgtattgt gaaatttgtt aatatatata     1080

atacttaaaa atatgtgagc atgaaactat gcacctataa atactaaata tgaaatttta     1140

ccattttgcg atgtgtttta ttcacttgtg tttgtatata aatggtgaga attaaaataa     1200

aacgttatct cattgcaaaa atattttatt tttatcccat ctcactttaa taataaaaat     1260

catgcttata agcaacatga attaagaact gacacaaagg acaaaaatat aaagttatta     1320

atagccattt gaagaaggag gaattttaga agaggtagag aaaatggaac attaacccta     1380

cactcggaat tccctgaagc aacactgcca gaagtgtgtt ttggtatgca ctggttcctt     1440

aagtggctgt gattaattat tgaaagtggg gtgttgaaga ccccaactac tattgtagag     1500

tggtctattt ctcccttcaa tcctgtcaat gtttgcttta cgtattttgg ggaactgttg     1560

tttgatgtgt atgtgtttat aattgttata catttttaat tgagcctttt attaacatat     1620

attgttattt ttgtctcgaa ataatttttt agttaaaatc tattttgtct gatattggtg     1680

tgaatgctgt acctttctga caataaataa tattcgacca tgaataaaaa aaaaaaaaaa     1740

gtgggttccc gggaactaag cagtgtagaa gatgattttg actacaccct ccttagagag     1800

ccataagaca cattagcaca tattagcaca ttcaaggctc tgagagaatg tggttaactt     1860

tgtttaactc agcattcctc actttttttt tttaatcatc agaaattctc tctctctctc     1920

tctctttttc tctcgctctc tttttttttt tttttttaca ggaaatgcct ttaaacatcg     1980

ttggaactac cagagtcacc ttaaaggaga tcaattctct agactgataa aaatttcatg     2040

gcctccttta aatgttgcca aatatatgaa ttctaggatt tttccttagg aaaggttttt     2100

ctctttcagg gaagatctat taactcccca tgggtgctga aaataaactt gatggtgaaa     2160

aactctgtat aaattaattt aaaaattatt tggtttctct ttttaattat tctggggcat     2220

agtcatttct aaaagtcact agtagaaagt ataatttcaa gacagaatat tctagacatg     2280

ctagcagttt atatgtattc atgagtaatg tgatatatat tgggcgctgg tgaggaagga     2340

aggaggaatg agtgactata aggatggtta ccatagaaac ttcctttttt acctaattga     2400

agagagacta ctacagagtg ctaagctgca tgtgtcatct tacactagag agaaatggta     2460

agtttcttgt tttatttaag ttatgtttaa gcaaggaaag gatttgttat tgaacagtat     2520

atttcaggaa ggttagaaag tggcggttag gatatatttt aaatctacct aaagcagcat     2580

attttaaaaa tttaaaagta ttggtattaa attaagaaat agaggacaga actagactga     2640

tagcagtgac ctagaacaat ttgagattag gaaagttgtg accatgaatt taaggattta     2700

tgtggataca aattctcctt taaagtgttt cttcccttaa tatttatctg acggtaattt     2760

ttgagcagtg aattacttta tatatcttaa tagtttattt gggaccaaac acttaaacaa     2820

aaagttcttt aagtcatata agccttttca ggaagcttgt ctcatattca ctcccgagac     2880

attcacctgc caagtggcct gaggatcaat ccagtcctag gtttattttg cagacttaca     2940

ttctcccaag ttattcagcc tcatatgact ccacggtcgg ctttaccaaa acagttcaga     3000

gtgcactttg gcacacaatt gggaacagaa caatctaatg tgtggtttgg tattccaagt     3060

ggggtctttt tcagaatctc tgcactagtg tgagatgcaa acatgtttcc tcatctttct     3120

ggcttatcca gtatgtagct atttgtgaca taataaatat atacatatat gaaaata        3177


<210> 7
<211> 9239
<212> RNA
<213> Homo sapiens


<220> 
<223> LRRK2 (cDNA - NCBI Reference Sequence: NM_198578.4)

<400> 7
ggggcccgcg gggagcgctg gctgcgggcg gtgagctgag ctcgcccccg gggagctgtg       60

gccggcgccc ctgccggttc cctgagcagc ggacgttcat gctgggaggg cggcgggttg      120

gaagcaggtg ccaccatggc tagtggcagc tgtcaggggt gcgaagagga cgaggaaact      180

ctgaagaagt tgatagtcag gctgaacaat gtccaggaag gaaaacagat agaaacgctg      240

gtccaaatcc tggaggatct gctggtgttc acgtactccg agcgcgcctc caagttattt      300

caaggcaaaa atatccatgt gcctctgttg atcgtcttgg actcctatat gagagtcgcg      360

agtgtgcagc aggtgggttg gtcacttctg tgcaaattaa tagaagtctg tccaggtaca      420

atgcaaagct taatgggacc ccaggatgtt ggaaatgatt gggaagtcct tggtgttcac      480

caattgattc ttaaaatgct aacagttcat aatgccagtg taaacttgtc agtgattgga      540

ctgaagacct tagatctcct cctaacttca ggtaaaatca ccttgctgat attggatgaa      600

gaaagtgata ttttcatgtt aatttttgat gccatgcact catttccagc caatgatgaa      660

gtccagaaac ttggatgcaa agctttacat gtgctgtttg agagagtctc agaggagcaa      720

ctgactgaat ttgttgagaa caaagattat atgatattgt taagtgcgtt aacaaatttt      780

aaagatgaag aggaaattgt gcttcatgtg ctgcattgtt tacattccct agcgattcct      840

tgcaataatg tggaagtcct catgagtggc aatgtcaggt gttataatat tgtggtggaa      900

gctatgaaag cattccctat gagtgaaaga attcaagaag tgagttgctg tttgctccat      960

aggcttacat taggtaattt tttcaatatc ctggtattaa acgaagtcca tgagtttgtg     1020

gtgaaagctg tgcagcagta cccagagaat gcagcattgc agatctcagc gctcagctgt     1080

ttggccctcc tcactgagac tattttctta aatcaagatt tagaggaaaa gaatgagaat     1140

caagagaatg atgatgaggg ggaagaagat aaattgtttt ggctggaagc ctgttacaaa     1200

gcattaacgt ggcatagaaa gaacaagcac gtgcaggagg ccgcatgctg ggcactaaat     1260

aatctcctta tgtaccaaaa cagtttacat gagaagattg gagatgaaga tggccatttc     1320

ccagctcata gggaagtgat gctctccatg ctgatgcatt cttcatcaaa ggaagttttc     1380

caggcatctg cgaatgcatt gtcaactctc ttagaacaaa atgttaattt cagaaaaata     1440

ctgttatcaa aaggaataca cctgaatgtt ttggagttaa tgcagaagca tatacattct     1500

cctgaagtgg ctgaaagtgg ctgtaaaatg ctaaatcatc tttttgaagg aagcaacact     1560

tccctggata taatggcagc agtggtcccc aaaatactaa cagttatgaa acgtcatgag     1620

acatcattac cagtgcagct ggaggcgctt cgagctattt tacattttat agtgcctggc     1680

atgccagaag aatccaggga ggatacagaa tttcatcata agctaaatat ggttaaaaaa     1740

cagtgtttca agaatgatat tcacaaactg gtcctagcag ctttgaacag gttcattgga     1800

aatcctggga ttcagaaatg tggattaaaa gtaatttctt ctattgtaca ttttcctgat     1860

gcattagaga tgttatccct ggaaggtgct atggattcag tgcttcacac actgcagatg     1920

tatccagatg accaagaaat tcagtgtctg ggtttaagtc ttataggata cttgattaca     1980

aagaagaatg tgttcatagg aactggacat ctgctggcaa aaattctggt ttccagctta     2040

taccgattta aggatgttgc tgaaatacag actaaaggat ttcagacaat cttagcaatc     2100

ctcaaattgt cagcatcttt ttctaagctg ctggtgcatc attcatttga cttagtaata     2160

ttccatcaaa tgtcttccaa tatcatggaa caaaaggatc aacagtttct aaacctctgt     2220

tgcaagtgtt ttgcaaaagt agctatggat gattacttaa aaaatgtgat gctagagaga     2280

gcgtgtgatc agaataacag catcatggtt gaatgcttgc ttctattggg agcagatgcc     2340

aatcaagcaa aggagggatc ttctttaatt tgtcaggtat gtgagaaaga gagcagtccc     2400

aaattggtgg aactcttact gaatagtgga tctcgtgaac aagatgtacg aaaagcgttg     2460

acgataagca ttgggaaagg tgacagccag atcatcagct tgctcttaag gaggctggcc     2520

ctggatgtgg ccaacaatag catttgcctt ggaggatttt gtataggaaa agttgaacct     2580

tcttggcttg gtcctttatt tccagataag acttctaatt taaggaaaca aacaaatata     2640

gcatctacac tagcaagaat ggtgatcaga tatcagatga aaagtgctgt ggaagaagga     2700

acagcctcag gcagcgatgg aaatttttct gaagatgtgc tgtctaaatt tgatgaatgg     2760

acctttattc ctgactcttc tatggacagt gtgtttgctc aaagtgatga cctggatagt     2820

gaaggaagtg aaggctcatt tcttgtgaaa aagaaatcta attcaattag tgtaggagaa     2880

ttttaccgag atgccgtatt acagcgttgc tcaccaaatt tgcaaagaca ttccaattcc     2940

ttggggccca tttttgatca tgaagattta ctgaagcgaa aaagaaaaat attatcttca     3000

gatgattcac tcaggtcatc aaaacttcaa tcccatatga ggcattcaga cagcatttct     3060

tctctggctt ctgagagaga atatattaca tcactagacc tttcagcaaa tgaactaaga     3120

gatattgatg ccctaagcca gaaatgctgt ataagtgttc atttggagca tcttgaaaag     3180

ctggagcttc accagaatgc actcacgagc tttccacaac agctatgtga aactctgaag     3240

agtttgacac atttggactt gcacagtaat aaatttacat catttccttc ttatttgttg     3300

aaaatgagtt gtattgctaa tcttgatgtc tctcgaaatg acattggacc ctcagtggtt     3360

ttagatccta cagtgaaatg tccaactctg aaacagttta acctgtcata taaccagctg     3420

tcttttgtac ctgagaacct cactgatgtg gtagagaaac tggagcagct cattttagaa     3480

ggaaataaaa tatcagggat atgctccccc ttgagactga aggaactgaa gattttaaac     3540

cttagtaaga accacatttc atccctatca gagaactttc ttgaggcttg tcctaaagtg     3600

gagagtttca gtgccagaat gaattttctt gctgctatgc ctttcttgcc tccttctatg     3660

acaatcctaa aattatctca gaacaaattt tcctgtattc cagaagcaat tttaaatctt     3720

ccacacttgc ggtctttaga tatgagcagc aatgatattc agtacctacc aggtcccgca     3780

cactggaaat ctttgaactt aagggaactc ttatttagcc ataatcagat cagcatcttg     3840

gacttgagtg aaaaagcata tttatggtct agagtagaga aactgcatct ttctcacaat     3900

aaactgaaag agattcctcc tgagattggc tgtcttgaaa atctgacatc tctggatgtc     3960

agttacaact tggaactaag atcctttccc aatgaaatgg ggaaattaag caaaatatgg     4020

gatcttcctt tggatgaact gcatcttaac tttgatttta aacatatagg atgtaaagcc     4080

aaagacatca taaggtttct tcaacagcga ttaaaaaagg ctgtgcctta taaccgaatg     4140

aaacttatga ttgtgggaaa tactgggagt ggtaaaacca ccttattgca gcaattaatg     4200

aaaaccaaga aatcagatct tggaatgcaa agtgccacag ttggcataga tgtgaaagac     4260

tggcctatcc aaataagaga caaaagaaag agagatctcg tcctaaatgt gtgggatttt     4320

gcaggtcgtg aggaattcta tagtactcat ccccatttta tgacgcagcg agcattgtac     4380

cttgctgtct atgacctcag caagggacag gctgaagttg atgccatgaa gccttggctc     4440

ttcaatataa aggctcgcgc ttcttcttcc cctgtgattc tcgttggcac acatttggat     4500

gtttctgatg agaagcaacg caaagcctgc atgagtaaaa tcaccaagga actcctgaat     4560

aagcgagggt tccctgccat acgagattac cactttgtga atgccaccga ggaatctgat     4620

gctttggcaa aacttcggaa aaccatcata aacgagagcc ttaatttcaa gatccgagat     4680

cagcttgttg ttggacagct gattccagac tgctatgtag aacttgaaaa aatcatttta     4740

tcggagcgta aaaatgtgcc aattgaattt cccgtaattg accggaaacg attattacaa     4800

ctagtgagag aaaatcagct gcagttagat gaaaatgagc ttcctcacgc agttcacttt     4860

ctaaatgaat caggagtcct tcttcatttt caagacccag cactgcagtt aagtgacttg     4920

tactttgtgg aacccaagtg gctttgtaaa atcatggcac agattttgac agtgaaagtg     4980

gaaggttgtc caaaacaccc taagggcatt atttcgcgta gagatgtgga aaaatttctt     5040

tcaaaaaaaa ggaaatttcc aaagaactac atgtcacagt attttaagct cctagaaaaa     5100

ttccagattg ctttgccaat aggagaagaa tatttgctgg ttccaagcag tttgtctgac     5160

cacaggcctg tgatagagct tccccattgt gagaactctg aaattatcat ccgactatat     5220

gaaatgcctt attttccaat gggattttgg tcaagattaa tcaatcgatt acttgagatt     5280

tcaccttaca tgctttcagg gagagaacga gcacttcgcc caaacagaat gtattggcga     5340

caaggcattt acttaaattg gtctcctgaa gcttattgtc tggtaggatc tgaagtctta     5400

gacaatcatc cagagagttt cttaaaaatt acagttcctt cttgtagaaa aggctgtatt     5460

cttttgggcc aagttgtgga ccacattgat tctctcatgg aagaatggtt tcctgggttg     5520

ctggagattg atatttgtgg tgaaggagaa actctgttga agaaatgggc attatatagt     5580

tttaatgatg gtgaagaaca tcaaaaaatc ttacttgatg acttgatgaa gaaagcagag     5640

gaaggagatc tcttagtaaa tccagatcaa ccaaggctca ccattccaat atctcagatt     5700

gcccctgact tgattttggc tgacctgcct agaaatatta tgttgaataa tgatgagttg     5760

gaatttgaac aagctccaga gtttctccta ggtgatggca gttttggatc agtttaccga     5820

gcagcctatg aaggagaaga agtggctgtg aagattttta ataaacatac atcactcagg     5880

ctgttaagac aagagcttgt ggtgctttgc cacctccacc accccagttt gatatctttg     5940

ctggcagctg ggattcgtcc ccggatgttg gtgatggagt tagcctccaa gggttccttg     6000

gatcgcctgc ttcagcagga caaagccagc ctcactagaa ccctacagca caggattgca     6060

ctccacgtag ctgatggttt gagatacctc cactcagcca tgattatata ccgagacctg     6120

aaaccccaca atgtgctgct tttcacactg tatcccaatg ctgccatcat tgcaaagatt     6180

gctgactacg gcattgctca gtactgctgt agaatgggga taaaaacatc agagggcaca     6240

ccagggtttc gtgcacctga agttgccaga ggaaatgtca tttataacca acaggctgat     6300

gtttattcat ttggtttact actctatgac attttgacaa ctggaggtag aatagtagag     6360

ggtttgaagt ttccaaatga gtttgatgaa ttagaaatac aaggaaaatt acctgatcca     6420

gttaaagaat atggttgtgc cccatggcct atggttgaga aattaattaa acagtgtttg     6480

aaagaaaatc ctcaagaaag gcctacttct gcccaggtct ttgacatttt gaattcagct     6540

gaattagtct gtctgacgag acgcatttta ttacctaaaa acgtaattgt tgaatgcatg     6600

gttgctacac atcacaacag caggaatgca agcatttggc tgggctgtgg gcacaccgac     6660

agaggacagc tctcatttct tgacttaaat actgaaggat acacttctga ggaagttgct     6720

gatagtagaa tattgtgctt agccttggtg catcttcctg ttgaaaagga aagctggatt     6780

gtgtctggga cacagtctgg tactctcctg gtcatcaata ccgaagatgg gaaaaagaga     6840

cataccctag aaaagatgac tgattctgtc acttgtttgt attgcaattc cttttccaag     6900

caaagcaaac aaaaaaattt tcttttggtt ggaaccgctg atggcaagtt agcaattttt     6960

gaagataaga ctgttaagct taaaggagct gctcctttga agatactaaa tataggaaat     7020

gtcagtactc cattgatgtg tttgagtgaa tccacaaatt caacggaaag aaatgtaatg     7080

tggggaggat gtggcacaaa gattttctcc ttttctaatg atttcaccat tcagaaactc     7140

attgagacaa gaacaagcca actgttttct tatgcagctt tcagtgattc caacatcata     7200

acagtggtgg tagacactgc tctctatatt gctaagcaaa atagccctgt tgtggaagtg     7260

tgggataaga aaactgaaaa actctgtgga ctaatagact gcgtgcactt tttaagggag     7320

gtaatggtaa aagaaaacaa ggaatcaaaa cacaaaatgt cttattctgg gagagtgaaa     7380

accctctgcc ttcagaagaa cactgctctt tggataggaa ctggaggagg ccatatttta     7440

ctcctggatc tttcaactcg tcgacttata cgtgtaattt acaacttttg taattcggtc     7500

agagtcatga tgacagcaca gctaggaagc cttaaaaatg tcatgctggt attgggctac     7560

aaccggaaaa atactgaagg tacacaaaag cagaaagaga tacaatcttg cttgaccgtt     7620

tgggacatca atcttccaca tgaagtgcaa aatttagaaa aacacattga agtgagaaaa     7680

gaattagctg aaaaaatgag acgaacatct gttgagtaag agagaaatag gaattgtctt     7740

tggataggaa aattattctc tcctcttgta aatatttatt ttaaaaatgt tcacatggaa     7800

agggtactca cattttttga aatagctcgt gtgtatgaag gaatgttatt atttttaatt     7860

taaatatatg taaaaatact taccagtaaa tgtgtatttt aaagaactat ttaaaacaca     7920

atgttatatt tcttataaat accagttact ttcgttcatt aattaatgaa aataaatctg     7980

tgaagtacct aatttaagta ctcatactaa aatttataag gccgataatt ttttgttttc     8040

ttgtctgtaa tggaggtaaa ctttatttta aattctgtgc ttaagacagg actattgctt     8100

gtcgattttt ctagaaatct gcacggtata atgaaaatat taagacagtt tcccatgtaa     8160

tgtattcctt cttagattgc atcgaaatgc actatcatat atgcttgtaa atattcaaat     8220

gaatttgcac taataaagtc ctttgttggt atgtgaattc tctttgttgc tgttgcaaac     8280

agtgcatctt acacaacttc actcaattca aaagaaaact ccattaaaag tactaatgaa     8340

aaaacatgac atactgtcaa agtcctcata tctaggaaag acacagaaac tctctttgtc     8400

acagaaactc tctgtgtctt tcctagacat aatagagttg tttttcaact ctatgtttga     8460

atgtggatac cctgaatttt gtataattag tgtaaataca gtgttcagtc cttcaagtga     8520

tatttttatt tttttattca taccactagc tacttgtttt ctaatctgct tcattctaat     8580

gcttatattc atcttttccc taaatttgtg atgctgcaga tcctacatca ttcagataga     8640

aacctttttt tttttcagaa ttatagaatt ccacagctcc taccaagacc atgaggataa     8700

atatctaaca cttttcagtt gctgaaggag aaaggagctt tagttatgat ggataaaaat     8760

atctgccacc ctaggcttcc aaattatact taaattgttt acatagctta ccacaatagg     8820

agtatcaggg ccaaatacct atgtaataat ttgaggtcat ttctgcttta ggaaaagtac     8880

tttcggtaaa ttctttggcc ctgaccagta ttcattattt cagataattc cctgtgatag     8940

gacaactagt acatttaata ttctcagaac ttatggcatt ttactatgtg aaaactttaa     9000

atttatttat attaagggta atcaaattct taaagatgaa agattttctg tattttaaag     9060

gaagctatgc tttaacttgt tatgtaatta acaaaaaaat catatataat agagctcttt     9120

gttccagtgt tatctctttc attgttactt tgtatttgca atttttttta ccaaagacaa     9180

attaaaaaaa tgaataccat atttaaatgg aataataaag gttttttaaa aactttaaa      9239


<210> 8
<211> 6776
<212> DNA
<213> Homo sapiens


<220> 
<223> VPS35 (cDNA - NCBI Reference Sequence: NM_018206.6)

<400> 8
acgcgcgggg cgggtgctgc ttgctgcagg ctctggggag tcgccatgcc tacaacacag       60

cagtcccctc aggatgagca ggaaaagctc ttggatgaag ccatacaggc tgtgaaggtc      120

cagtcattcc aaatgaagag atgcctggac aaaaacaagc ttatggatgc tctaaaacat      180

gcttctaata tgcttggtga actccggact tctatgttat caccaaagag ttactatgaa      240

ctttatatgg ccatttctga tgaactgcac tacttggagg tctacctgac agatgagttt      300

gctaaaggaa ggaaagtggc agatctctac gaacttgtac agtatgctgg aaacattatc      360

ccaaggcttt accttttgat cacagttgga gttgtatatg tcaagtcatt tcctcagtcc      420

aggaaggata ttttgaaaga tttggtagaa atgtgccgtg gtgtgcaaca tcccttgagg      480

ggtctgtttc ttcgaaatta ccttcttcag tgtaccagaa atatcttacc tgatgaagga      540

gagccaacag atgaagaaac aactggtgac atcagtgatt ccatggattt tgtactgctc      600

aactttgcag aaatgaacaa gctctgggtg cgaatgcagc atcagggaca tagccgagat      660

agagaaaaaa gagaacgaga aagacaagaa ctgagaattt tagtgggaac aaatttggtg      720

cgcctcagtc agttggaagg tgtaaatgtg gaacgttaca aacagattgt tttgactggc      780

atattggagc aagttgtaaa ctgtagggat gctttggctc aagaatatct catggagtgt      840

attattcagg ttttccctga tgaatttcac ctccagactt tgaatccttt tcttcgggcc      900

tgtgctgagt tacaccagaa tgtaaatgtg aagaacataa tcattgcttt aattgataga      960

ttagctttat ttgctcaccg tgaagatgga cctggaatcc cagcggatat taaacttttt     1020

gatatatttt cacagcaggt ggctacagtg atacagtcta gacaagacat gccttcagag     1080

gatgttgtat ctttacaagt ctctctgatt aatcttgcca tgaaatgtta ccctgatcgt     1140

gtggactatg ttgataaagt tctagaaaca acagtggaga tattcaataa gctcaacctt     1200

gaacatattg ctaccagtag tgcagtttca aaggaactca ccagactttt gaaaatacca     1260

gttgacactt acaacaatat tttaacagtc ttgaaattaa aacattttca cccactcttt     1320

gagtactttg actacgagtc cagaaagagc atgagttgtt atgtgcttag taatgttctg     1380

gattataaca cagaaattgt ctctcaagac caggtggatt ccataatgaa tttggtatcc     1440

acgttgattc aagatcagcc agatcaacct gtagaagacc ctgatccaga agattttgct     1500

gatgagcaga gccttgtggg ccgcttcatt catctgctgc gctctgagga ccctgaccag     1560

cagtacttga ttttgaacac agcacgaaaa cattttggag ctggtggaaa tcagcggatt     1620

cgcttcacac tgccaccttt ggtatttgca gcttaccagc tggcttttcg atataaagag     1680

aattctaaag tggatgacaa atgggaaaag aaatgccaga agattttttc atttgcccac     1740

cagactatca gtgctttgat caaagcagag ctggcagaat tgcccttaag actttttctt     1800

caaggagcac tagctgctgg ggaaattggt tttgaaaatc atgagacagt cgcatatgaa     1860

ttcatgtccc aggcattttc tctgtatgaa gatgaaatca gcgattccaa agcacagcta     1920

gctgccatca ccttgatcat tggcactttt gaaaggatga agtgcttcag tgaagagaat     1980

cacgaacctc tgaggactca gtgtgccctt gctgcatcca aacttctaaa gaaacctgat     2040

cagggccgag ctgtgagcac ctgtgcacat ctcttctggt ctggcagaaa cacggacaaa     2100

aatggggagg agcttcacgg aggcaagagg gtaatggagt gcctaaaaaa agctctaaaa     2160

atagcaaatc agtgcatgga cccctctcta caagtgcagc tttttataga aattctgaac     2220

agatatatct atttttatga aaaggaaaat gatgcggtaa caattcaggt tttaaaccag     2280

cttatccaaa agattcgaga agacctcccg aatcttgaat ccagtgaaga aacagagcag     2340

attaacaaac attttcataa cacactggag catttgcgct tgcggcggga atcaccagaa     2400

tccgaggggc caatttatga aggtctcatc ctttaaaaag gaaatagctc accatactcc     2460

tttccatgta catccagtga gggttttatt acgctaggtt tcccttccat agattgtgcc     2520

tttcagaaat gctgaggtag gtttcccatt tcttacctgt gatgtgtttt acccagcacc     2580

tccggacact caccttcagg accttaataa aattattcac ttggtaagtg ttcaagtctt     2640

tctgatcacc ccaagtagca tgactgatct gcaatttaaa attcctgtga tctgtaaaaa     2700

aaaaaaaaaa aaaaaacaca aaacccacaa gcacttatct tggctactaa tgaagctctc     2760

cttttttttg tttgtttgtt tgcttcattg ttgattgtgt attttcttca ttcctgggga     2820

gtactaaccc aaaagcgtct gtctcttgtt ttctagtcca gtttgagatt aatttagaag     2880

aaaggaatac tgtatgtgaa attcatcttg ggctttcccc taaattgcaa gataaggcca     2940

tgtgtaagat tttccctaaa actagaatat attaatgcat gtttgagaat tttaaagcac     3000

catggtcaaa accagaagct atattttgca tatttggact cagccatcca ttaagaaccc     3060

atgttgtcct ctggacatat ttatcaatat aattgggttt taaatagtat aaaagaaaac     3120

ttgtgatcta tataatttat gtatcacctt cattgtaaat ttagcaggaa atgcatcaca     3180

attatgattt ttttttttgc accagtgaaa caataaagat gctattaaca attttggagc     3240

tttttttccc ctttcatact atctttaatt gataaaaagt actagtagta tggctataga     3300

gtttaatagt cattctcata tattcacaga gctcacttaa ctctagtttt aagcacttgt     3360

tgaacaaggc agcatctact cttttagtca tttatacccc ttttctttcc tcaactttac     3420

cctgcttttc ccaaggcatg atgaattcac ataaaccccc caaaggctca ccaccgatac     3480

tagttaccta ctatataata aaccatccca aaacttactg tcttaaaaca gcaaacattt     3540

atctcacagg tctctggatc aggaatttgg gagcagctta gctggtggtt ctggcaaaga     3600

gtgtggtgta aggttgcaaa caagatactg gttggggctg cagtcatctg atgctttgac     3660

tggggctgac ttttctgctc actgacctgg ctgttaggca gaggccccag ttcctcttct     3720

tgagggcaga ggccccagtt cctctccttg agggcagagg cctaagttcc tttccttgag     3780

ggcagaggcc ccagttcctc tccttgacgg cccttccata gagtgtcctc acagcatggt     3840

ggctggcttt cccctgagta tgaaagcaag aaggaaacca cagtgccttt cagtggcctc     3900

cctgtggaag tgacatgctc atttttgcct tattctgtaa gtggggagtc actaagtcta     3960

gcctatattc aagggtaagg agaattaagc tccacctctt aaagggaaaa tttatagaca     4020

ttttcaaatg actacatcac ttaacccctc accatctgcc ctcccattgc tagcacttga     4080

tgactagccc ttgctgggct ttacatgaac agatgtttcc caaagttata aaattagtac     4140

cactaaaatg tatcaaatgt taagccattc tgtggtatgt catagtccag caaacccttt     4200

ctgttctttg taggtgttag tttaccccgt ataaacctga ttatggcttg acatgtccat     4260

attatttaca tgttttgtga aatacaactg gaatagtaga aaagacatga gtcaagaaca     4320

cttgagttgg agagcttggt ttgcaagtaa ggtaatgtca gtacagtgtg taaattatct     4380

cttattttct gggttgaggt aaacccaatt ttaaaaataa taaaccaaca aaagtaaata     4440

aaagtgaaac aaaagcactg ctagtatcct taacttacag attttttttg ttgaacaaaa     4500

actgggtacc agatatagtt aggcactgaa tctaaaggtg aagaagatca tagcctctag     4560

cttcaagaac gttagtctgc tgtgaagaca gacctgtagt tacagaagat ggtaagggtt     4620

tgtgcaggag agcagtgaag aagagctttg agggattggg gatggggaag ttctgcagag     4680

ggttgtatga attctcatgg aacatcaagt ccaatagttt atttagcctt ctgaggccag     4740

tgctttggcc tgcagtccca ggctcctcag acccatgggc tgaagcaagt tatactcttg     4800

gctgcctgta gtgaaataga tatttagaaa ttgacttagc atttaaaacc ctttatagca     4860

atttgacaga gtaattttat gtctattgga tgtaataaat atttggcttt gtgctttgtg     4920

tgtctgctat tccctgttct ccttttttag taatttttat tgtgtcttac aaaaaagtac     4980

ctgtccttaa ttggggtgtg gtggggaatc cctcacaggt ggatggaaac gctgaaccag     5040

ggcaggcttg gtgctgaatg gcattaaatt ccaagactag gggatagttt ggggggacac     5100

atctaggaag atgctgtgac tggatgagag atgcctgccg tgttagactt tcctaccctc     5160

cctttcctgc ctctacccag gaaaccagtg attcttagag tccagatgat cccttctttg     5220

cctagaaatt catgtttctg actcatcctc aagcctgaaa ttggtggtca tcaggttaat     5280

gaactgcaaa aacagcccct gctgatagac actgctcaaa gagagaggcg tttgagttga     5340

tcaggcacca gagcacctag aaggagaatg atgagcactt gtgtacagtt cgtgtgcagc     5400

tctcaaaggc attgagaaat gtgacagacc tcaaggaata aatgcaccac cacaggcact     5460

gaggggattt aaacacaaag tctaggttcc agaggggtct tctgttaaca tttgctctct     5520

cattcagaga cctcaaggta ataagctcaa gcagaaagga tttcccaaca gaattgtctt     5580

tgacaatggg aattccagac tgcatattgt aaatgaaagg tagagaaatc tgtgcaggag     5640

accttcctgt ttgctggggt ttgtcctatg gggatgctgt aggcatggac aacagacact     5700

gattcaggtg ccagtatcta cacatttacc atacacttga attcccaaga gtagtgactt     5760

gccttaggtt tgattaaaga caaatgtttc ctggcttgtg gtcttgtatt gctgattact     5820

ccagtagggc accctgcatt gtccaacaaa atggtccatg cttccaaaat ctctggagag     5880

ggactgtata ttttattttt ttgagacgga gtcttgctct gtcacccaag caggagtgca     5940

gtggtgcgat cttggctcac tgcaacctcc gcctccccag ttcaagcaat tctcctgcct     6000

cagcctcccg agtagctggg attacaggcg tgcaccacca tgcctggcta atttttgtat     6060

ttttagtaca gatgggggtt tcaccatgtt ggccaggctg gtcacgaact tctgaccttg     6120

tgatccacct ggctcagcct cccaaagtgc tggaattaca ggcatgagcc accttgccca     6180

gccagattgt atattgtacc actcattgct gtgttcaggc ttgcatcagt agtgtcttca     6240

aataagtaaa atcttaggct gtgacttaaa tccattttca cttagagaaa tagaaacaca     6300

aggaaacctt tggacgcttc ataactgctg ggaaaggggt attatcaatt gtgtttgaga     6360

gtcaaactat aaattacttc ccaaggttag ttctacctat gcccaggaat gaacaaggac     6420

agcttaaagg ttagaagcaa gatggagtca tttgggtctg atctctttca ctgtcataat     6480

ttcctcagtt acaatttttg taaaggtggt ttcaaatgct ttgctgacct cccataaaca     6540

aggatgtgcc aattgtaact tcagttctgc aattcaagtc tgctcccaaa actaaagtcc     6600

attgaattgc atactgattg ataatgttca ttacgagttt atcttcccat gtgcagagca     6660

aagacaagag gagatcagcc attcctccac ctacccagag acgttgcatt ggaaaggagc     6720

cgtatcttct agtatggttt tgcaaatgta aaatgtaaaa tctatgcacg ctcaca         6776


<210> 9
<211> 2657
<212> DNA
<213> Homo sapiens


<220> 
<223> PINK1 (cDNA - NCBI Reference Sequence: NM_032409.3)

<400> 9
agaggcaccg ccccaagttt gttgtgaccg gcgggggacg ccggtggtgg cggcagcggc      60

ggctgcgggg gcaccgggcc gcggcgccac catggcggtg cgacaggcgc tgggccgcgg     120

cctgcagctg ggtcgagcgc tgctgctgcg cttcacgggc aagcccggcc gggcctacgg     180

cttggggcgg ccgggcccgg cggcgggctg tgtccgcggg gagcgtccag gctgggccgc     240

aggaccgggc gcggagcctc gcagggtcgg gctcgggctc cctaaccgtc tccgcttctt     300

ccgccagtcg gtggccgggc tggcggcgcg gttgcagcgg cagttcgtgg tgcgggcctg     360

gggctgcgcg ggcccttgcg gccgggcagt ctttctggcc ttcgggctag ggctgggcct     420

catcgaggaa aaacaggcgg agagccggcg ggcggtctcg gcctgtcagg agatccaggc     480

aatttttacc cagaaaagca agccggggcc tgacccgttg gacacgagac gcttgcaggg     540

ctttcggctg gaggagtatc tgatagggca gtccattggt aagggctgca gtgctgctgt     600

gtatgaagcc accatgccta cattgcccca gaacctggag gtgacaaaga gcaccgggtt     660

gcttccaggg agaggcccag gtaccagtgc accaggagaa gggcaggagc gagctccggg     720

ggcccctgcc ttccccttgg ccatcaagat gatgtggaac atctcggcag gttcctccag     780

cgaagccatc ttgaacacaa tgagccagga gctggtccca gcgagccgag tggccttggc     840

tggggagtat ggagcagtca cttacagaaa atccaagaga ggtcccaagc aactagcccc     900

tcaccccaac atcatccggg ttctccgcgc cttcacctct tccgtgccgc tgctgccagg     960

ggccctggtc gactaccctg atgtgctgcc ctcacgcctc caccctgaag gcctgggcca    1020

tggccggacg ctgttcctcg ttatgaagaa ctatccctgt accctgcgcc agtacctttg    1080

tgtgaacaca cccagccccc gcctcgccgc catgatgctg ctgcagctgc tggaaggcgt    1140

ggaccatctg gttcaacagg gcatcgcgca cagagacctg aaatccgaca acatccttgt    1200

ggagctggac ccagacggct gcccctggct ggtgatcgca gattttggct gctgcctggc    1260

tgatgagagc atcggcctgc agttgccctt cagcagctgg tacgtggatc ggggcggaaa    1320

cggctgtctg atggccccag aggtgtccac ggcccgtcct ggccccaggg cagtgattga    1380

ctacagcaag gctgatgcct gggcagtggg agccatcgcc tatgaaatct tcgggcttgt    1440

caatcccttc tacggccagg gcaaggccca ccttgaaagc cgcagctacc aagaggctca    1500

gctacctgca ctgcccgagt cagtgcctcc agacgtgaga cagttggtga gggcactgct    1560

ccagcgagag gccagcaaga gaccatctgc ccgagtagcc gcaaatgtgc ttcatctaag    1620

cctctggggt gaacatattc tagccctgaa gaatctgaag ttagacaaga tggttggctg    1680

gctcctccaa caatcggccg ccactttgtt ggccaacagg ctcacagaga agtgttgtgt    1740

ggaaacaaaa atgaagatgc tctttctggc taacctggag tgtgaaacgc tctgccaggc    1800

agccctcctc ctctgctcat ggagggcagc cctgtgatgt ccctgcatgg agctggtgaa    1860

ttactaaaag aacatggcat cctctgtgtc gtgatggtct gtgaatggtg agggtgggag    1920

tcaggagaca agacagcgca gagagggctg gttagccgga aaaggcctcg ggcttggcaa    1980

atggaagaac ttgagtgaga gttcagtctg cagtcctctg ctcacagaca tctgaaaagt    2040

gaatggccaa gctggtctag tagatgaggc tggactgagg aggggtaggc ctgcatccac    2100

agagaggatc caggccaagg cactggctgt cagtggcaga gtttggctgt gacctttgcc    2160

cctaacacga ggaactcgtt tgaagggggc agcgtagcat gtctgatttg ccacctggat    2220

gaaggcagac atcaacatgg gtcagcacgt tcagttacgg gagtgggaaa ttacatgagg    2280

cctgggcctc tgcgttccca agctgtgcgt tctggaccag ctactgaatt attaatctca    2340

cttagcgaaa gtgacggatg agcagtaagt aagtaagtgt ggggatttaa acttgagggt    2400

ttccctcctg actagcctct cttacaggaa ttgtgaaata ttaaatgcaa atttacaact    2460

gcagatgacg tatgtgcctt gaactgaata tttggcttta agaatgattc ttatactctg    2520

aaggtgagaa tattttgtgg gcaggtatca acattgggga agagatttca tgtctaacta    2580

actaacttta tacatgattt ttaggaagct attgcctaaa tcagcgtcaa catgcagtaa    2640

aggttgtctt caactga                                                   2657


<210> 10
<211> 4178
<212> DNA
<213> Homo sapiens


<220> 
<223> PRKN (cDNA - NCBI Reference Sequence: NM_004562.3)

<400> 10
aggatttaac ccaggagagc cgctggtggg aggcgcggct ggcgccgctg cgcgcatggg       60

cctgttcctg gcccgcagcc gccacctacc cagtgaccat gatagtgttt gtcaggttca      120

actccagcca tggtttccca gtggaggtcg attctgacac cagcatcttc cagctcaagg      180

aggtggttgc taagcgacag ggggttccgg ctgaccagtt gcgtgtgatt ttcgcaggga      240

aggagctgag gaatgactgg actgtgcaga attgtgacct ggatcagcag agcattgttc      300

acattgtgca gagaccgtgg agaaaaggtc aagaaatgaa tgcaactgga ggcgacgacc      360

ccagaaacgc ggcgggaggc tgtgagcggg agccccagag cttgactcgg gtggacctca      420

gcagctcagt cctcccagga gactctgtgg ggctggctgt cattctgcac actgacagca      480

ggaaggactc accaccagct ggaagtccag caggtagatc aatctacaac agcttttatg      540

tgtattgcaa aggcccctgt caaagagtgc agccgggaaa actcagggta cagtgcagca      600

cctgcaggca ggcaacgctc accttgaccc agggtccatc ttgctgggat gatgttttaa      660

ttccaaaccg gatgagtggt gaatgccaat ccccacactg ccctgggact agtgcagaat      720

ttttctttaa atgtggagca caccccacct ctgacaagga aacatcagta gctttgcacc      780

tgatcgcaac aaatagtcgg aacatcactt gcattacgtg cacagacgtc aggagccccg      840

tcctggtttt ccagtgcaac tcccgccacg tgatttgctt agactgtttc cacttatact      900

gtgtgacaag actcaatgat cggcagtttg ttcacgaccc tcaacttggc tactccctgc      960

cttgtgtggc tggctgtccc aactccttga ttaaagagct ccatcacttc aggattctgg     1020

gagaagagca gtacaaccgg taccagcagt atggtgcaga ggagtgtgtc ctgcagatgg     1080

ggggcgtgtt atgcccccgc cctggctgtg gagcggggct gctgccggag cctgaccaga     1140

ggaaagtcac ctgcgaaggg ggcaatggcc tgggctgtgg gtttgccttc tgccgggaat     1200

gtaaagaagc gtaccatgaa ggggagtgca gtgccgtatt tgaagcctca ggaacaacta     1260

ctcaggccta cagagtcgat gaaagagccg ccgagcaggc tcgttgggaa gcagcctcca     1320

aagaaaccat caagaaaacc accaagccct gtccccgctg ccatgtacca gtggaaaaaa     1380

atggaggctg catgcacatg aagtgtccgc agccccagtg caggctcgag tggtgctgga     1440

actgtggctg cgagtggaac cgcgtctgca tgggggacca ctggttcgac gtgtagccag     1500

ggcggccggg cgccccatcg ccacatcctg ggggagcata cccagtgtct accttcattt     1560

tctaattctc ttttcaaaca cacacacaca cgcgcgcgcg cgcacacaca ctcttcaagt     1620

ttttttcaaa gtccaactac agccaaattg cagaagaaac tcctggatcc ctttcactat     1680

gtccatgaaa aacagcagag taaaattaca gaagaagctc ctgaatccct ttcagtttgt     1740

ccacacaaga cagcagagcc atctgcgaca ccaccaacag gcgttctcag cctccggatg     1800

acacaaatac cagagcacag attcaagtgc aatccatgta tctgtatggg tcattctcac     1860

ctgaattcga gacaggcaga atcagtagct ggagagagag ttctcacatt taatatcctg     1920

ccttttacct tcagtaaaca ccatgaagat gccattgaca aggtgtttct ctgtaaaatg     1980

aactgcagtg ggttctccaa actagattca tggctttaac agtaatgttc ttatttaaat     2040

tttcagaaag catctattcc caaagaaccc caggcaatag tcaaaaacat ttgtttatcc     2100

ttaagaattc catctatata aatcgcatta atgaaatacc aactatgcgt aaatcaactt     2160

gtcacaaagt gagaaattat gaaagttaat ttgaatgttg aatgtttgaa ttacagggaa     2220

gaaatcaagt taatgtactt tcattccctt tcatgatttg caactttaga aagaaattgt     2280

ttttctgaaa gtatcaccaa aaaatctata gtttgattct gagtattcat tttgcaactt     2340

ggagattttg ctaatacatt tggctccact gtaaatttaa tagataaagt gcctataaag     2400

gaaacacgtt tagaaatgat ttcaaaatga tattcaatct taacaaaagt gaacattatt     2460

aaatcagaat ctttaaagag gagcctttcc agaactacca aaatgaagac acgcccgact     2520

ctctccatca gaagggttta tacccctttg gcacaccctc tctgtccaat ctgcaagtcc     2580

cagggagctc tgcataccag gggttcccca ggagagacct tctcttagga cagtaaactc     2640

actagaatat tccttatgtt gacatggatt ggatttcagt tcaatcaaac tttcagcttt     2700

tttttcagcc attcacaaca caatcaaaag attaacaaca ctgcatgcgg caaaccgcat     2760

gctcttaccc acactacgca gaagagaaag tacaaccact atcttttgtt ctacctgtat     2820

tgtctgactt ctcaggaaga tcgtgaacat aactgagggc atgagtctca ctagcacatg     2880

gaggcccttt tggatttaga gactgtaaat tattaaatcg gcaacagggc ttctcttttt     2940

agatgtagca ctgaaatcct tgctggaggg aagagagggg atgaactcaa gttttccaca     3000

tcctgggaca cctgtccctc ttttcctaac tgcctaagat aacccatttc ttccaaccat     3060

ctgaggacag tcccgtcgtc tcagaggccc tgcaccgggg agagactggg ctctgcagca     3120

gccacatcag cattcacagc ttcatgtggc ttcactgtct gaaaatctac cgactccaac     3180

atggccccac ggtgacaaca gacctgtgac aggaagccca aagctcacat agaaatggtg     3240

gacagatcaa agtctctata gtaagggaaa aaaagagagg tggcaggcat gagccccctg     3300

cacccagtgg ctcgtgtcca tactgagtcc agaccctgat caaggcctga cttagtgtca     3360

ctggcagtcc cactaaatta cacttcctta cactggcccg atgcgacaaa tcaggtggct     3420

cccttctgtc acgtggagca cacagtgttt tccatcatcc atagctttct tcctgatggt     3480

gtttgcatta ttgcgccttc ccaatctgca tgctgcgttg ggcttgcggt gcctgaacaa     3540

ggtttgctcc catgagctca ggcaccctag gatcccctgt tagactatta ggctgtccag     3600

catggtctcc tttcccttct tggtggtggt cttttccctt tccagaatag aacagtgatt     3660

cttaaaataa gttagagcag gccgggcgcg gtggctcatg cctgtaatcc cagcactttg     3720

ggaggccgag gtgggtggat cacgaggtca ggagttcaag accagcctgg ccaagatgat     3780

gaaaccccgt ctctattaaa aatacaaaaa ttagctgggc gtggtggcag gcacctgtaa     3840

tcccagcttc ctgggaggct gaggcaggag aatcacttga acccgggggg cagaggttgc     3900

agtgagccga gatcacgcca ctgaactcca gcctgggcaa cagagtgaga ctctgtctca     3960

aaaaaaaaaa aaaaacaaaa acaaaaaagc aagatcatcc actacacatg aacatgaatc     4020

acagtattat ttgcacagga agggtgtaac aaaatatgaa tgtatcaaaa aatagaaata     4080

aagtctttgc agaaaaagtc tgtttttctc tgaagtgtgt tgagattatc tgacaactct     4140

aagattgtac ttaaattgtc aataaagcat caaaagag                             4178


<210> 11
<211> 656
<212> PRT
<213> Homo sapiens


<220> 
<223> MTHFR (UniProtKB - P42898 (MTHR_HUMAN); HGNC:7436)

<400> 11
Met Val Asn Glu Ala Arg Gly Asn Ser Ser Leu Asn Pro Cys Leu Glu 
1               5                   10                  15      
Gly Ser Ala Ser Ser Gly Ser Glu Ser Ser Lys Asp Ser Ser Arg Cys 
            20                  25                  30          
Ser Thr Pro Gly Leu Asp Pro Glu Arg His Glu Arg Leu Arg Glu Lys 
        35                  40                  45              
Met Arg Arg Arg Leu Glu Ser Gly Asp Lys Trp Phe Ser Leu Glu Phe 
    50                  55                  60                  
Phe Pro Pro Arg Thr Ala Glu Gly Ala Val Asn Leu Ile Ser Arg Phe 
65                  70                  75                  80  
Asp Arg Met Ala Ala Gly Gly Pro Leu Tyr Ile Asp Val Thr Trp His 
                85                  90                  95      
Pro Ala Gly Asp Pro Gly Ser Asp Lys Glu Thr Ser Ser Met Met Ile 
            100                 105                 110         
Ala Ser Thr Ala Val Asn Tyr Cys Gly Leu Glu Thr Ile Leu His Met 
        115                 120                 125             
Thr Cys Cys Arg Gln Arg Leu Glu Glu Ile Thr Gly His Leu His Lys 
    130                 135                 140                 
Ala Lys Gln Leu Gly Leu Lys Asn Ile Met Ala Leu Arg Gly Asp Pro 
145                 150                 155                 160 
Ile Gly Asp Gln Trp Glu Glu Glu Glu Gly Gly Phe Asn Tyr Ala Val 
                165                 170                 175     
Asp Leu Val Lys His Ile Arg Ser Glu Phe Gly Asp Tyr Phe Asp Ile 
            180                 185                 190         
Cys Val Ala Gly Tyr Pro Lys Gly His Pro Glu Ala Gly Ser Phe Glu 
        195                 200                 205             
Ala Asp Leu Lys His Leu Lys Glu Lys Val Ser Ala Gly Ala Asp Phe 
    210                 215                 220                 
Ile Ile Thr Gln Leu Phe Phe Glu Ala Asp Thr Phe Phe Arg Phe Val 
225                 230                 235                 240 
Lys Ala Cys Thr Asp Met Gly Ile Thr Cys Pro Ile Val Pro Gly Ile 
                245                 250                 255     
Phe Pro Ile Gln Gly Tyr His Ser Leu Arg Gln Leu Val Lys Leu Ser 
            260                 265                 270         
Lys Leu Glu Val Pro Gln Glu Ile Lys Asp Val Ile Glu Pro Ile Lys 
        275                 280                 285             
Asp Asn Asp Ala Ala Ile Arg Asn Tyr Gly Ile Glu Leu Ala Val Ser 
    290                 295                 300                 
Leu Cys Gln Glu Leu Leu Ala Ser Gly Leu Val Pro Gly Leu His Phe 
305                 310                 315                 320 
Tyr Thr Leu Asn Arg Glu Met Ala Thr Thr Glu Val Leu Lys Arg Leu 
                325                 330                 335     
Gly Met Trp Thr Glu Asp Pro Arg Arg Pro Leu Pro Trp Ala Leu Ser 
            340                 345                 350         
Ala His Pro Lys Arg Arg Glu Glu Asp Val Arg Pro Ile Phe Trp Ala 
        355                 360                 365             
Ser Arg Pro Lys Ser Tyr Ile Tyr Arg Thr Gln Glu Trp Asp Glu Phe 
    370                 375                 380                 
Pro Asn Gly Arg Trp Gly Asn Ser Ser Ser Pro Ala Phe Gly Glu Leu 
385                 390                 395                 400 
Lys Asp Tyr Tyr Leu Phe Tyr Leu Lys Ser Lys Ser Pro Lys Glu Glu 
                405                 410                 415     
Leu Leu Lys Met Trp Gly Glu Glu Leu Thr Ser Glu Glu Ser Val Phe 
            420                 425                 430         
Glu Val Phe Val Leu Tyr Leu Ser Gly Glu Pro Asn Arg Asn Gly His 
        435                 440                 445             
Lys Val Thr Cys Leu Pro Trp Asn Asp Glu Pro Leu Ala Ala Glu Thr 
    450                 455                 460                 
Ser Leu Leu Lys Glu Glu Leu Leu Arg Val Asn Arg Gln Gly Ile Leu 
465                 470                 475                 480 
Thr Ile Asn Ser Gln Pro Asn Ile Asn Gly Lys Pro Ser Ser Asp Pro 
                485                 490                 495     
Ile Val Gly Trp Gly Pro Ser Gly Gly Tyr Val Phe Gln Lys Ala Tyr 
            500                 505                 510         
Leu Glu Phe Phe Thr Ser Arg Glu Thr Ala Glu Ala Leu Leu Gln Val 
        515                 520                 525             
Leu Lys Lys Tyr Glu Leu Arg Val Asn Tyr His Leu Val Asn Val Lys 
    530                 535                 540                 
Gly Glu Asn Ile Thr Asn Ala Pro Glu Leu Gln Pro Asn Ala Val Thr 
545                 550                 555                 560 
Trp Gly Ile Phe Pro Gly Arg Glu Ile Ile Gln Pro Thr Val Val Asp 
                565                 570                 575     
Pro Val Ser Phe Met Phe Trp Lys Asp Glu Ala Phe Ala Leu Trp Ile 
            580                 585                 590         
Glu Arg Trp Gly Lys Leu Tyr Glu Glu Glu Ser Pro Ser Arg Thr Ile 
        595                 600                 605             
Ile Gln Tyr Ile His Asp Asn Tyr Phe Leu Val Asn Leu Val Asp Asn 
    610                 615                 620                 
Asp Phe Pro Leu Asp Asn Cys Leu Trp Gln Val Val Glu Asp Thr Leu 
625                 630                 635                 640 
Glu Leu Leu Asn Arg Pro Thr Gln Asn Ala Arg Glu Thr Glu Ala Pro 
                645                 650                 655     



