               SEQUENCE LISTING

<110> Merck Patent GmbH

<120> VHH-Based NKp30 Binders

<130> P21-100-WO-PCT

<140> EPPCT/EP2022/066963
<141> 2022-06-22

<150> EP21180872.0
<151> 2021-06-22

<160> 96

<170> BiSSAP 1.3.6

<210> 1
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH1

<400> 1
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          
Thr Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Glu His Glu Gly Val 
        35                  40                  45              
Ser Cys Phe Ser Pro Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Phe Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Phe Ala Asp Gly Ser Ser Trp Cys Tyr Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     

<210> 2
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH2

<400> 2
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gln Thr Trp Thr Asn Tyr 
            20                  25                  30          
His Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Ala Arg Glu Ser Val 
        35                  40                  45              
Ala Ser Ile Glu Trp Gly Gly Arg Gly Thr Tyr Ala Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Gln Ser Ser Ser Arg Ser Pro Leu Glu Ser Asn Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 3
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH3

<400> 3
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Leu Val Ser Gly Val Thr Tyr His Phe Tyr 
            20                  25                  30          
Asp Ile Thr Trp Phe Arg Gln Ala Pro Gly Leu Glu Arg Glu Gly Val 
        35                  40                  45              
Ser Cys Ile Ser Tyr Ala Ser Gly Thr Thr Lys Phe Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  
Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Thr Gln Gly Ser Gly Ser Cys Ser Asp Phe Met Ser Ala Gly Ser 
            100                 105                 110         
Val Leu Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210> 4
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH4

<400> 4
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Leu Val Ser Gly Val Thr Tyr His Phe Tyr 
            20                  25                  30          
Asp Ile Thr Trp Phe Arg Gln Ala Pro Gly Leu Glu Arg Glu Gly Val 
        35                  40                  45              
Ser Cys Ile Ser Tyr Ala Ser Gly Ser Thr Lys Phe Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Met Gln Gly Ser Gly Ser Cys Ser Asp Phe Met Ser Ala Asp Ser 
            100                 105                 110         
Val Leu Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210> 5
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH5

<400> 5
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Leu Val Ser Gly Val Thr Tyr His Phe Tyr 
            20                  25                  30          
Asp Ile Thr Trp Phe Arg Gln Ala Pro Gly Leu Glu Arg Glu Gly Val 
        35                  40                  45              
Ser Cys Ile Ser Tyr Ala Ser Gly Ser Thr Lys Phe Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Thr Gln Gly Ser Gly Ser Cys Ser Asp Phe Met Ser Ala Asp Ser 
            100                 105                 110         
Val Leu Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210> 6
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH6

<400> 6
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Pro Phe Ser Lys Tyr 
            20                  25                  30          
Ala Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Ser Glu Phe Leu 
        35                  40                  45              
Val Val Val Ser Trp Ser Gly Asp Lys Phe Tyr Gln Asp Asn Met Lys 
    50                  55                  60                  
Gly Arg Cys Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ala Tyr Leu 
65                  70                  75                  80  
Gln Ile Asn Ser Leu Gln Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Ser Gly Ser Tyr Pro Val Thr Asp Arg Tyr Phe Tyr Asn Phe Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

<210> 7
<211> 129
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH7

<400> 7
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Asp Met Gly Trp Tyr Arg Gln Val Pro Gly Lys Glu Cys Glu Leu Val 
        35                  40                  45              
Ala Ala Ile Phe Ser Ala Gly Gly Ser Thr Ile Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Asn Lys Ala Pro Pro Phe Thr Thr Ile Gln Pro Thr Cys Val Met Ile 
            100                 105                 110         
Asp Thr Gln Leu Gly Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             
Ser 
    

<210> 8
<211> 129
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH8

<400> 8
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Cys Glu Leu Val 
        35                  40                  45              
Ala Ala Ile Phe Ser Ala Asp Gly Ser Thr Ile Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Phe 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Asn Lys Ala Pro Pro Phe Thr Thr Ile Gln Pro Met Cys Val Met Ile 
            100                 105                 110         
Asp Thr Gln Leu Gly Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             
Ser 
    

<210> 9
<211> 129
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH9

<400> 9
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Gly Gly Ala Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Ser Trp Thr Gly Asp Thr Thr Tyr Asn Val Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Pro Val Tyr 
65                  70                  75                  80  
Leu Asp Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ala His Trp Thr Arg Val Val Ala Lys Gly Ala Met Ala Asp 
            100                 105                 110         
Glu Lys Lys Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             
Ser 
    

<210> 10
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH10

<400> 10
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Asn 
            20                  25                  30          
Phe Met Gly Trp Phe Arg Gln Ala Pro Asn Lys Asp Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile His Trp Ser Gly Gly Ser Arg Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asp Thr Val Tyr 
65                  70                  75                  80  
Leu Leu Val Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Glu Ile Ser Trp Gln Thr Thr Gly Trp Thr Asn Leu Gly Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 11
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH11

<400> 11
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Asp 
            20                  25                  30          
Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile His Trp Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  
Leu Leu Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Glu Ile Arg Trp Leu Thr Thr Gly Trp Ala Asn Leu Gly Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 12
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH12

<400> 12
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Asp 
            20                  25                  30          
Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile His Trp Ser Gly Gly Ser Arg Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  
Leu Leu Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Glu Ile Arg Trp Gln Thr Thr Gly Trp Ala Asn Leu Gly Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 13
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH13

<400> 13
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      
Pro Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Ser Asp 
            20                  25                  30          
Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile His Trp Ser Gly Gly Ser Arg Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  
Leu Leu Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Glu Ile Arg Trp Gln Thr Ala Gly Trp Val Asn Leu Gly Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 14
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH14

<400> 14
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Val Thr Phe Asn Phe Tyr 
            20                  25                  30          
Ser Met Thr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              
Ala Asp Ile Thr Ser Glu Gly Arg Thr Glu Tyr Ala His Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Ile Ile Ser Arg Asp Asp Phe Gly Thr Met Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      
Thr Gly Gly Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110     

<210> 15
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH15

<400> 15
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Thr Phe Arg Leu Asn 
            20                  25                  30          
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Leu Arg Asp Leu Val 
        35                  40                  45              
Ala Gly Ile Thr Ala Asp Gly Gly Val Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Asn Thr Ala Pro Ala Asn Trp Gly Ser Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 16
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH16

<400> 16
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Ile Phe Ser Ser Leu 
            20                  25                  30          
Thr Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              
Ala Gly Ile Thr Thr Asp Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      
Lys Ser Pro Tyr Tyr Asp Pro Thr Asp Tyr Asp Ser Trp Gly Gln Gly 
            100                 105                 110         
Thr Gln Val Thr Val Ser Ser 
        115                 

<210> 17
<211> 454
<212> PRT
<213> Homo sapiens


<220> 
<223> Human B7-H6

<400> 17
Met Thr Trp Arg Ala Ala Ala Ser Thr Cys Ala Ala Leu Leu Ile Leu 
1               5                   10                  15      
Leu Trp Ala Leu Thr Thr Glu Gly Asp Leu Lys Val Glu Met Met Ala 
            20                  25                  30          
Gly Gly Thr Gln Ile Thr Pro Leu Asn Asp Asn Val Thr Ile Phe Cys 
        35                  40                  45              
Asn Ile Phe Tyr Ser Gln Pro Leu Asn Ile Thr Ser Met Gly Ile Thr 
    50                  55                  60                  
Trp Phe Trp Lys Ser Leu Thr Phe Asp Lys Glu Val Lys Val Phe Glu 
65                  70                  75                  80  
Phe Phe Gly Asp His Gln Glu Ala Phe Arg Pro Gly Ala Ile Val Ser 
                85                  90                  95      
Pro Trp Arg Leu Lys Ser Gly Asp Ala Ser Leu Arg Leu Pro Gly Ile 
            100                 105                 110         
Gln Leu Glu Glu Ala Gly Glu Tyr Arg Cys Glu Val Val Val Thr Pro 
        115                 120                 125             
Leu Lys Ala Gln Gly Thr Val Gln Leu Glu Val Val Ala Ser Pro Ala 
    130                 135                 140                 
Ser Arg Leu Leu Leu Asp Gln Val Gly Met Lys Glu Asn Glu Asp Lys 
145                 150                 155                 160 
Tyr Met Cys Glu Ser Ser Gly Phe Tyr Pro Glu Ala Ile Asn Ile Thr 
                165                 170                 175     
Trp Glu Lys Gln Thr Gln Lys Phe Pro His Pro Ile Glu Ile Ser Glu 
            180                 185                 190         
Asp Val Ile Thr Gly Pro Thr Ile Lys Asn Met Asp Gly Thr Phe Asn 
        195                 200                 205             
Val Thr Ser Cys Leu Lys Leu Asn Ser Ser Gln Glu Asp Pro Gly Thr 
    210                 215                 220                 
Val Tyr Gln Cys Val Val Arg His Ala Ser Leu His Thr Pro Leu Arg 
225                 230                 235                 240 
Ser Asn Phe Thr Leu Thr Ala Ala Arg His Ser Leu Ser Glu Thr Glu 
                245                 250                 255     
Lys Thr Asp Asn Phe Ser Ile His Trp Trp Pro Ile Ser Phe Ile Gly 
            260                 265                 270         
Val Gly Leu Val Leu Leu Ile Val Leu Ile Pro Trp Lys Lys Ile Cys 
        275                 280                 285             
Asn Lys Ser Ser Ser Ala Tyr Thr Pro Leu Lys Cys Ile Leu Lys His 
    290                 295                 300                 
Trp Asn Ser Phe Asp Thr Gln Thr Leu Lys Lys Glu His Leu Ile Phe 
305                 310                 315                 320 
Phe Cys Thr Arg Ala Trp Pro Ser Tyr Gln Leu Gln Asp Gly Glu Ala 
                325                 330                 335     
Trp Pro Pro Glu Gly Ser Val Asn Ile Asn Thr Ile Gln Gln Leu Asp 
            340                 345                 350         
Val Phe Cys Arg Gln Glu Gly Lys Trp Ser Glu Val Pro Tyr Val Gln 
        355                 360                 365             
Ala Phe Phe Ala Leu Arg Asp Asn Pro Asp Leu Cys Gln Cys Cys Arg 
    370                 375                 380                 
Ile Asp Pro Ala Leu Leu Thr Val Thr Ser Gly Lys Ser Ile Asp Asp 
385                 390                 395                 400 
Asn Ser Thr Lys Ser Glu Lys Gln Thr Pro Arg Glu His Ser Asp Ala 
                405                 410                 415     
Val Pro Asp Ala Pro Ile Leu Pro Val Ser Pro Ile Trp Glu Pro Pro 
            420                 425                 430         
Pro Ala Thr Thr Ser Thr Thr Pro Val Leu Ser Ser Gln Pro Pro Thr 
        435                 440                 445             
Leu Leu Leu Pro Leu Gln 
    450                 

<210> 18
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 of VHH1

<400> 18
Ala Thr Ser Gly Phe Thr Leu Asp Asp Tyr Thr Ile Gly 
1               5                   10              

<210> 19
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 of VHH1

<400> 19
Cys Phe Ser Pro Ser Asp Gly Thr Thr Tyr 
1               5                   10  

<210> 20
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 of VHH1

<400> 20
Ala Ala Ser Phe Ala Asp Gly Ser Ser Trp Cys Tyr Asp Tyr Trp 
1               5                   10                  15  

<210> 21
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 of VHH2

<400> 21
Ala Val Ser Gly Gln Thr Trp Thr Asn Tyr His Ile Gly 
1               5                   10              

<210> 22
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 of VHH2

<400> 22
Ser Ile Glu Trp Gly Gly Arg Gly Thr Tyr Ala 
1               5                   10      

<210> 23
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 of VHH2

<400> 23
Ala Ala Gln Ser Ser Ser Arg Ser Pro Leu Glu Ser Asn Tyr Asp Tyr 
1               5                   10                  15      
Trp 
    

<210> 24
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 of VHH3

<400> 24
Leu Val Ser Gly Val Thr Tyr His Phe Tyr Asp Ile Thr 
1               5                   10              

<210> 25
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 of VHH3

<400> 25
Cys Ile Ser Tyr Ala Ser Gly Thr Thr Lys Phe 
1               5                   10      

<210> 26
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 of VHH3

<400> 26
Ala Thr Gln Gly Ser Gly Ser Cys Ser Asp Phe Met Ser Ala Gly Ser 
1               5                   10                  15      
Val Leu Ser Trp 
            20  

<210> 27
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 of VHH4

<400> 27
Leu Val Ser Gly Val Thr Tyr His Phe Tyr Asp Ile Thr 
1               5                   10              

<210> 28
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 of VHH4

<400> 28
Cys Ile Ser Tyr Ala Ser Gly Ser Thr Lys Phe 
1               5                   10      

<210> 29
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 of VHH4

<400> 29
Ala Met Gln Gly Ser Gly Ser Cys Ser Asp Phe Met Ser Ala Asp Ser 
1               5                   10                  15      
Val Leu Ser Trp 
            20  

<210> 30
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 of VHH5

<400> 30
Leu Val Ser Gly Val Thr Tyr His Phe Tyr Asp Ile Thr 
1               5                   10              

<210> 31
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 of VHH5

<400> 31
Cys Ile Ser Tyr Ala Ser Gly Ser Thr Lys Phe 
1               5                   10      

<210> 32
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 of VHH5

<400> 32
Ala Thr Gln Gly Ser Gly Ser Cys Ser Asp Phe Met Ser Ala Asp Ser 
1               5                   10                  15      
Val Leu Ser Trp 
            20  

<210> 33
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 of VHH6

<400> 33
Ala Ala Ser Gly Leu Pro Phe Ser Lys Tyr Ala Ile Ala 
1               5                   10              

<210> 34
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 of VHH6

<400> 34
Val Val Ser Trp Ser Gly Asp Lys Phe Tyr 
1               5                   10  

<210> 35
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 of VHH6

<400> 35
Ala Ala Ser Gly Ser Tyr Pro Val Thr Asp Arg Tyr Phe Tyr Asn Phe 
1               5                   10                  15      
Trp 
    

<210> 36
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 of VHH7

<400> 36
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asp Met Gly 
1               5                   10              

<210> 37
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 of VHH7

<400> 37
Ala Ala Ile Phe Ser Ala Gly Gly Ser Thr Ile Tyr Ala 
1               5                   10              

<210> 38
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 of VHH7

<400> 38
Asn Lys Ala Pro Pro Phe Thr Thr Ile Gln Pro Thr Cys Val Met Ile 
1               5                   10                  15      
Asp Thr Gln Leu Gly Ala Trp 
            20              

<210> 39
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 of VHH8

<400> 39
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asp Met Gly 
1               5                   10              

<210> 40
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 of VHH8

<400> 40
Ala Ala Ile Phe Ser Ala Asp Gly Ser Thr Ile Tyr Ala 
1               5                   10              

<210> 41
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 of VHH8

<400> 41
Asn Lys Ala Pro Pro Phe Thr Thr Ile Gln Pro Met Cys Val Met Ile 
1               5                   10                  15      
Asp Thr Gln Leu Gly Ala Trp 
            20              

<210> 42
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 of VHH9

<400> 42
Ala Ala Ser Gly Arg Gly Gly Ala Ser Tyr Ala Met Gly 
1               5                   10              

<210> 43
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 of VHH9

<400> 43
Ala Ala Ile Ser Trp Thr Gly Asp Thr Thr Tyr Asn 
1               5                   10          

<210> 44
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 of VHH9

<400> 44
Ala Ala Ala His Trp Thr Arg Val Val Ala Lys Gly Ala Met Ala Asp 
1               5                   10                  15      
Glu Lys Lys Tyr Glu Tyr Trp 
            20              

<210> 45
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 of VHH10

<400> 45
Ala Ala Ser Gly Arg Thr Phe Ser Ser Asn Phe Met Gly 
1               5                   10              

<210> 46
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 of VHH10

<400> 46
Ala Ala Ile His Trp Ser Gly Gly Ser Arg Ala Tyr Ala 
1               5                   10              

<210> 47
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 of VHH10

<400> 47
Ala Ala Glu Ile Ser Trp Gln Thr Thr Gly Trp Thr Asn Leu Gly Ser 
1               5                   10                  15      
Trp 
    

<210> 48
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 of VHH11

<400> 48
Ala Ala Ser Gly Arg Thr Phe Ser Ser Asp Phe Met Gly 
1               5                   10              

<210> 49
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 of VHH11

<400> 49
Ala Ala Ile His Trp Ser Gly Gly Ser Thr Ser Tyr Ala 
1               5                   10              

<210> 50
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 of VHH11

<400> 50
Ala Ala Glu Ile Arg Trp Leu Thr Thr Gly Trp Ala Asn Leu Gly Ser 
1               5                   10                  15      
Trp 
    

<210> 51
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 of VHH12

<400> 51
Ala Ala Ser Gly Arg Thr Phe Ser Ser Asp Phe Met Gly 
1               5                   10              

<210> 52
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 of VHH12

<400> 52
Ala Ala Ile His Trp Ser Gly Gly Ser Arg Ser Tyr Ala 
1               5                   10              

<210> 53
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 of VHH12

<400> 53
Ala Ala Glu Ile Arg Trp Gln Thr Thr Gly Trp Ala Asn Leu Gly Ser 
1               5                   10                  15      
Trp 
    

<210> 54
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 of VHH13

<400> 54
Ala Ala Ser Gly Arg Thr Phe Thr Ser Asp Phe Met Gly 
1               5                   10              

<210> 55
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 of VHH13

<400> 55
Ala Ala Ile His Trp Ser Gly Gly Ser Arg Ser Tyr Ala 
1               5                   10              

<210> 56
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 of VHH13

<400> 56
Ala Ala Glu Ile Arg Trp Gln Thr Ala Gly Trp Val Asn Leu Gly Ser 
1               5                   10                  15      
Trp 
    

<210> 57
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 of VHH14

<400> 57
Glu Ala Ser Gly Val Thr Phe Asn Phe Tyr Ser Met Thr 
1               5                   10              

<210> 58
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 of VHH14

<400> 58
Ala Asp Ile Thr Ser Glu Gly Arg Thr Glu Tyr Ala 
1               5                   10          

<210> 59
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 of VHH14

<400> 59
Tyr Thr Gly Gly Ser Trp 
1               5       

<210> 60
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 of VHH15

<400> 60
Ala Val Ser Gly Ser Thr Phe Arg Leu Asn Val Met Gly 
1               5                   10              

<210> 61
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 of VHH15

<400> 61
Ala Gly Ile Thr Ala Asp Gly Gly Val Thr Asn Tyr Ala 
1               5                   10              

<210> 62
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 of VHH15

<400> 62
Asn Thr Ala Pro Ala Asn Trp Gly Ser Trp 
1               5                   10  

<210> 63
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 of VHH16

<400> 63
Thr Ala Ser Gly Ser Ile Phe Ser Ser Leu Thr Met Ala Trp 
1               5                   10                  

<210> 64
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 of VHH16

<400> 64
Ala Gly Ile Thr Thr Asp Gly Ser Thr Asp Tyr Ala 
1               5                   10          

<210> 65
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 of VHH16

<400> 65
Asn Lys Ser Pro Tyr Tyr Asp Pro Thr Asp Tyr Asp Ser Trp 
1               5                   10                  

<210> 66
<211> 117
<212> PRT
<213> Homo sapiens


<220> 
<223> human NKp30 extracellular domain

<400> 66
Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      
Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile 
            20                  25                  30          
Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              
Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser 
    50                  55                  60                  
Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  
Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      
Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu 
            100                 105                 110         
His Pro Gln Leu Gly 
        115         

<210> 67
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH1.1 (humanized)

<400> 67
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          
Thr Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Glu His Glu Gly Val 
        35                  40                  45              
Ser Cys Phe Ser Pro Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Phe Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Phe Ala Asp Gly Ser Ser Trp Cys Tyr Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 68
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH1.2 (humanized)

<400> 68
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          
Thr Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Glu His Glu Gly Val 
        35                  40                  45              
Ser Cys Phe Ser Pro Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Phe Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Phe Ala Asp Gly Ser Ser Trp Cys Tyr Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 69
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH1.3 (humanized)

<400> 69
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          
Thr Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Glu His Glu Gly Val 
        35                  40                  45              
Ser Cys Phe Ser Pro Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Phe Ala Asp Gly Ser Ser Trp Cys Tyr Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 70
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH1.4 (humanized)

<400> 70
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          
Thr Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              
Ser Cys Phe Ser Pro Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Phe Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Phe Ala Asp Gly Ser Ser Trp Cys Tyr Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 71
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH1.5 (humanized)

<400> 71
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          
Thr Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              
Ser Cys Phe Ser Pro Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Phe Ala Asp Gly Ser Ser Trp Cys Tyr Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 72
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH1.6 (humanized)

<400> 72
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          
Thr Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              
Ser Cys Phe Ser Pro Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Phe Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Phe Ala Asp Gly Ser Ser Trp Cys Tyr Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 73
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH1.7 (humanized)

<400> 73
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          
Thr Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              
Ser Cys Phe Ser Pro Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Phe Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Phe Ala Asp Gly Ser Ser Trp Cys Tyr Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 74
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH1.8 (humanized)

<400> 74
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          
Thr Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              
Ser Cys Phe Ser Pro Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Phe Ala Asp Gly Ser Ser Trp Cys Tyr Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 75
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH1.9 (humanized)

<400> 75
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          
Thr Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              
Ser Cys Phe Ser Pro Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Phe Ala Asp Gly Ser Ser Trp Cys Tyr Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 76
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH1.10 (humanized)

<400> 76
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          
Thr Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Cys Phe Ser Pro Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Phe Ala Asp Gly Ser Ser Trp Cys Tyr Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 77
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH1.11 (humanized)

<400> 77
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          
Thr Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Glu His Glu Gly Val 
        35                  40                  45              
Ser Cys Phe Ser Pro Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Phe Ala Asp Gly Ser Ser Trp Cys Tyr Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 78
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH1.12 (humanized)

<400> 78
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          
Thr Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Glu His Glu Gly Val 
        35                  40                  45              
Ser Cys Phe Ser Pro Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Phe Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Phe Ala Asp Gly Ser Ser Trp Cys Tyr Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 79
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH2.1 (humanized)

<400> 79
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gln Thr Trp Thr Asn Tyr 
            20                  25                  30          
His Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Ala Arg Glu Ser Val 
        35                  40                  45              
Ala Ser Ile Glu Trp Gly Gly Arg Gly Thr Tyr Ala Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Gln Ser Ser Ser Arg Ser Pro Leu Glu Ser Asn Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 80
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH2.2 (humanized)

<400> 80
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gln Thr Trp Thr Asn Tyr 
            20                  25                  30          
His Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Ala Arg Glu Ser Val 
        35                  40                  45              
Ala Ser Ile Glu Trp Gly Gly Arg Gly Thr Tyr Ala Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Gln Ser Ser Ser Arg Ser Pro Leu Glu Ser Asn Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 81
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH2.3 (humanized)

<400> 81
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gln Thr Trp Thr Asn Tyr 
            20                  25                  30          
His Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Ala Arg Glu Ser Val 
        35                  40                  45              
Ala Ser Ile Glu Trp Gly Gly Arg Gly Thr Tyr Ala Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Gln Ser Ser Ser Arg Ser Pro Leu Glu Ser Asn Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 82
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH2.4 (humanized)

<400> 82
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gln Thr Trp Thr Asn Tyr 
            20                  25                  30          
His Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Ala Arg Glu Ser Val 
        35                  40                  45              
Ala Ser Ile Glu Trp Gly Gly Arg Gly Thr Tyr Ala Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Gln Ser Ser Ser Arg Ser Pro Leu Glu Ser Asn Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 83
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH2.5 (humanized)

<400> 83
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gln Thr Trp Thr Asn Tyr 
            20                  25                  30          
His Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Val 
        35                  40                  45              
Ala Ser Ile Glu Trp Gly Gly Arg Gly Thr Tyr Ala Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Gln Ser Ser Ser Arg Ser Pro Leu Glu Ser Asn Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 84
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH2.6 (humanized)

<400> 84
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gln Thr Trp Thr Asn Tyr 
            20                  25                  30          
His Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Val 
        35                  40                  45              
Ala Ser Ile Glu Trp Gly Gly Arg Gly Thr Tyr Ala Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Gln Ser Ser Ser Arg Ser Pro Leu Glu Ser Asn Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 85
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH2.7 (humanized)

<400> 85
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gln Thr Trp Thr Asn Tyr 
            20                  25                  30          
His Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Val 
        35                  40                  45              
Ala Ser Ile Glu Trp Gly Gly Arg Gly Thr Tyr Ala Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Gln Ser Ser Ser Arg Ser Pro Leu Glu Ser Asn Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 86
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH2.8 (humanized)

<400> 86
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gln Thr Trp Thr Asn Tyr 
            20                  25                  30          
His Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Glu Trp Gly Gly Arg Gly Thr Tyr Ala Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Gln Ser Ser Ser Arg Ser Pro Leu Glu Ser Asn Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 87
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH2.9 (humanized)

<400> 87
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gln Thr Trp Thr Asn Tyr 
            20                  25                  30          
His Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Val 
        35                  40                  45              
Ala Ser Ile Glu Trp Gly Gly Arg Gly Thr Tyr Ala Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Gln Ser Ser Ser Arg Ser Pro Leu Glu Ser Asn Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 88
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH2.10 (humanized)

<400> 88
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gln Thr Trp Thr Asn Tyr 
            20                  25                  30          
His Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Glu Trp Gly Gly Arg Gly Thr Tyr Ala Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Gln Ser Ser Ser Arg Ser Pro Leu Glu Ser Asn Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 89
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH2.11 (humanized)

<400> 89
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gln Thr Trp Thr Asn Tyr 
            20                  25                  30          
His Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Val 
        35                  40                  45              
Ala Ser Ile Glu Trp Gly Gly Arg Gly Thr Tyr Ala Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Gln Ser Ser Ser Arg Ser Pro Leu Glu Ser Asn Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 90
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH2.12 (humanized)

<400> 90
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gln Thr Trp Thr Asn Tyr 
            20                  25                  30          
His Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Glu Trp Gly Gly Arg Gly Thr Tyr Ala Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Gln Ser Ser Ser Arg Ser Pro Leu Glu Ser Asn Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 91
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH2.13 (humanized)

<400> 91
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gln Thr Trp Thr Asn Tyr 
            20                  25                  30          
His Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Val 
        35                  40                  45              
Ala Ser Ile Glu Trp Gly Gly Arg Gly Thr Tyr Ala Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Gln Ser Ser Ser Arg Ser Pro Leu Glu Ser Asn Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 92
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH2.14 (humanized)

<400> 92
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gln Thr Trp Thr Asn Tyr 
            20                  25                  30          
His Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Glu Trp Gly Gly Arg Gly Thr Tyr Ala Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Gln Ser Ser Ser Arg Ser Pro Leu Glu Ser Asn Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 93
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH2.15 (humanized)

<400> 93
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gln Thr Trp Thr Asn Tyr 
            20                  25                  30          
His Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Val 
        35                  40                  45              
Ala Ser Ile Glu Trp Gly Gly Arg Gly Thr Tyr Ala Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Gln Ser Ser Ser Arg Ser Pro Leu Glu Ser Asn Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 94
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH2.16 (humanized)

<400> 94
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gln Thr Trp Thr Asn Tyr 
            20                  25                  30          
His Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Glu Trp Gly Gly Arg Gly Thr Tyr Ala Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Gln Ser Ser Ser Arg Ser Pro Leu Glu Ser Asn Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 95
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH2.17 (humanized)

<400> 95
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gln Thr Trp Thr Asn Tyr 
            20                  25                  30          
His Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Val 
        35                  40                  45              
Ala Ser Ile Glu Trp Gly Gly Arg Gly Thr Tyr Ala Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Gln Ser Ser Ser Arg Ser Pro Leu Glu Ser Asn Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 96
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> VHH2.18 (humanized)

<400> 96
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gln Thr Trp Thr Asn Tyr 
            20                  25                  30          
His Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Glu Trp Gly Gly Arg Gly Thr Tyr Ala Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Gln Ser Ser Ser Arg Ser Pro Leu Glu Ser Asn Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

