                         б

<110>  ǺҽҩƼ޹˾

<120>  CD8϶ļ;

<130>  0173-PA-010

<160>  59

<170>  PatentIn version 3.5

<210>  1
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37 VHH

<400>  1

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Ser Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  2
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-YHDMS VHH

<400>  2

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn His Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  3
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-S72R VHH

<400>  3

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Ser Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  4
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-T85S VHH

<400>  4

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Ser Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  5
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-D109A VHH

<400>  5

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Ser Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  6
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-RA VHH

<400>  6

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Ser Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  7
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-RSA VHH

<400>  7

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Ser Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  8
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-F1 VHH

<400>  8

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn His Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Leu 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  9
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37H VHH

<400>  9

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn His Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Leu 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  10
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-H1 VHH

<400>  10

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn His Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Leu 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  11
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-H2 VHH

<400>  11

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn His Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Leu 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  12
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-H3 VHH

<400>  12

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn His Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Leu 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  13
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-H4 VHH

<400>  13

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn His Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Leu 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  14
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-YHDMS VHH; C37-S72R VHH; C37-T85S VHH; C37-D109A VHH; C37-RA VHH; C37-RSA VHH; C37-F1 VHH; C37H VHH; C37-H1 VHH; C37-H2 VHH; C37-H3 VHH; C37-H4 VHH

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = GluSer

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa = GlyArg

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa = AsnArg

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa = SerTyr

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa = HisGln

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa = IleMet

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa = AlaAsp

<220>
<221>  misc_feature
<222>  (112)..(112)
<223>  Xaa = LeuMet

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  Xaa = LysGln

<400>  14

Gln Xaa Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Xaa Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Xaa Xaa Thr Tyr Xaa Ala Xaa Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Xaa Asp Asn Xaa Lys Asn Xaa Val Tyr 
65                  70                  75                  80  


Leu Gln Xaa Asn Xaa Leu Xaa Xaa Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Xaa Tyr Asp Xaa 
            100                 105                 110         


Asp Tyr Trp Gly Xaa Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  15
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-S72R VHH; C37-T85S VHH; C37-D109A VHH; C37-RA VHH; C37-RSA VHH

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa = AlaAsp

<400>  15

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Ser Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Xaa Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Xaa Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Xaa Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  16
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-F1 VHH; C37H VHH; C37-H1 VHH; C37-H2 VHH; C37-H3 VHH; C37-H4 VHH

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa = GlyArg

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa = AsnArg

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  Xaa = LysGln

<400>  16

Gln Xaa Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Xaa Xaa Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Xaa Lys Asn His Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Xaa Xaa Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Leu 
            100                 105                 110         


Asp Tyr Trp Gly Xaa Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  17
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-YHDMS CDR1; C37-S72R CDR1; C37-T85S CDR1; C37-D109A CDR1; C37-RA CDR1; C37-RSA CDR1

<400>  17

Gly Leu Thr Phe Glu Asp Tyr 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-F1 CDR1; C37H CDR1; C37-H1 CDR1; C37-H2 CDR1; C37-H3 CDR1; C37-H4 CDR1

<400>  18

Gly Leu Thr Phe Ser Asp Tyr 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-YHDMS CDR1; C37-S72R CDR1; C37-T85S CDR1; C37-D109A CDR1; C37-RA CDR1; C37-RSA CDR1; C37-F1 CDR1; C37H CDR1; C37-H1 CDR1; C37-H2 CDR1; C37-H3 CDR1; C37-H4 CDR1

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = GluSer

<400>  19

Gly Leu Thr Phe Xaa Asp Tyr 
1               5           


<210>  20
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-YHDMS CDR2; C37-S72R CDR2; C37-T85S CDR2; C37-D109A CDR2; C37-RA CDR2; C37-RSA CDR2; C37-F1 CDR2; C37H CDR2; C37-H3 CDR2; C37-H4 CDR2

<400>  20

Arg Ile Tyr Asp Gly Asn 
1               5       


<210>  21
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-H1 CDR2

<400>  21

Arg Ile Tyr Asp Gly Arg 
1               5       


<210>  22
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-H2 CDR2

<400>  22

Arg Ile Tyr Asp Arg Asn 
1               5       


<210>  23
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-YHDMS CDR2; C37-S72R CDR2; C37-T85S CDR2; C37-D109A CDR2; C37-RA CDR2; C37-RSA CDR2; C37-F1 CDR2; C37H CDR2; C37-H3 CDR2; C37-H4 CDR2; C37-H1 CDR2; C37-H2 CDR2

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = GlyArg

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = AsnArg

<400>  23

Arg Ile Tyr Asp Xaa Xaa 
1               5       


<210>  24
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-YHDMS CDR3; C37-S72R CDR3; C37-T85S CDR3

<400>  24

Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Met Asp Tyr 
1               5                   10                  15      


<210>  25
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-D109A CDR3; C37-RA CDR3; C37-RSA CDR3

<400>  25

Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Met Asp Tyr 
1               5                   10                  15      


<210>  26
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-F1 CDR3; C37H CDR3; C37-H1 CDR3; C37-H2 CDR3; C37-H3 CDR3; C37-H4 CDR3

<400>  26

Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Leu Asp Tyr 
1               5                   10                  15      


<210>  27
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-YHDMS CDR3; C37-S72R CDR3; C37-T85S CDR3; C37-D109A CDR3; C37-RA CDR3; C37-RSA CDR3; C37-F1 CDR3; C37H CDR3; C37-H1 CDR3; C37-H2 CDR3; C37-H3 CDR3; C37-H4 CDR3

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = AlaAsp

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = LeuMet

<400>  27

Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Xaa Tyr Asp Xaa Asp Tyr 
1               5                   10                  15      


<210>  28
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-YHDMS CDR3; C37-S72R CDR3; C37-T85S CDR3; C37-D109A CDR3; C37-RA CDR3; C37-RSA CDR3

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = AlaAsp

<400>  28

Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Xaa Tyr Asp Met Asp Tyr 
1               5                   10                  15      


<210>  29
<211>  126
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37H-C VHH

<400>  29

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn His Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Leu 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Cys 
        115                 120                 125     


<210>  30
<211>  128
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37H-VDC VHH

<400>  30

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn His Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Leu 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Val Asp Cys 
        115                 120                 125             


<210>  31
<211>  128
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37H-GSC VHH

<400>  31

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn His Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Leu 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Ser Cys 
        115                 120                 125             


<210>  32
<211>  128
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37H-GGC VHH

<400>  32

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn His Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Leu 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Cys 
        115                 120                 125             


<210>  33
<211>  141
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-cHis VHH

<400>  33

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Ser Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Ser Met 
        115                 120                 125             


Asp Pro Gly Gly Ser His His His His His His His His 
    130                 135                 140     


<210>  34
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-S60Y VHH

<400>  34

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  35
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-ST-YS VHH

<400>  35

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  36
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-YDS VHH

<400>  36

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  37
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-YMS VHH

<400>  37

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  38
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-YDMS VHH

<400>  38

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  39
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-KL-QQ VHH

<400>  39

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Ser Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  40
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-D111A VHH

<400>  40

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Ser Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  41
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-D31Y VHH

<400>  41

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Ser Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  42
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-M112L VHH

<400>  42

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Ser Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Leu 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  43
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-TMS VHH

<400>  43

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Ser Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  44
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-E30S VHH

<400>  44

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Ser Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  45
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-SA VHH

<400>  45

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Ser Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  46
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-SR VHH

<400>  46

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Ser Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  47
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-SRA VHH

<400>  47

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Ser Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  48
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-SRS VHH

<400>  48

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Ser Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  49
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-R VHH

<400>  49

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  50
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-TRA VHH

<400>  50

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  51
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-YDMS-A VHH

<400>  51

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  52
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-YDTMS-A VHH

<400>  52

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  53
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-YDTMS-R VHH

<400>  53

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  54
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-YDMS-SR VHH

<400>  54

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Asp Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  55
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-YDMS-SRA VHH

<400>  55

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  56
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-F VHH

<400>  56

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Leu 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  57
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-F2 VHH

<400>  57

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Gln Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Leu 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  58
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-F4 VHH

<400>  58

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Leu 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  59
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C37-F5 VHH

<400>  59

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Arg Ile Tyr Asp Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Tyr Tyr Ser Cys Ser Val Tyr Pro Ala Tyr Asp Leu 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 



