                         SEQUENCE LISTING

<110>  NANJING IMMUNOPHAGE BIOTECH CO.,LTD
 
<120>  Anti-CCR8 antibodies and uses thereof

<130>  20210617

<150>  PCT/CN2021/102324

<151>  2021-06-25

<150>  PCT/CN2022/092803

<151>  2022-05-13

<160>  111

<170>  PatentIn version 3.5

<210>  1
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 101E4

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Pro Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Asn Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp Tyr Tyr Gly Gly Arg Ser Ser Ile Gly Met Asp 
            100                 105                 110         


Tyr Trp Gly His Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1

<400>  2

Gly Phe Ser Phe Asn Pro Tyr Ala 
1               5               


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2

<400>  3

Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3

<400>  4

Val Arg Asp Tyr Tyr Gly Gly Arg Ser Ser Ile Gly Met Asp Tyr 
1               5                   10                  15  


<210>  5
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 101E4

<400>  5

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1

<400>  6

Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  7
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2

<400>  7

Arg Met Ser 
1           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3

<400>  8

Leu Gln His Leu Glu Tyr Pro Phe Thr 
1               5                   


<210>  9
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 103G4

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Pro Tyr 
            20                  25                  30          


Ala Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Asn Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Lys Asp Tyr Tyr Gly Thr Arg Pro Ser Ile Gly Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3

<400>  10

Val Lys Asp Tyr Tyr Gly Thr Arg Pro Ser Ile Gly Met Asp Tyr 
1               5                   10                  15  


<210>  11
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 103G4

<400>  11

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Arg Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro His Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1

<400>  12

Arg Ser Leu Leu His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3

<400>  13

Phe Gln Gly Ser Gly Tyr Pro Leu Thr 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3

<400>  14

Met Gln His Leu Glu Tyr Pro Phe Thr 
1               5                   


<210>  15
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 118H1

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Pro Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Ala Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Asn Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Lys Asn Leu Ile Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp Tyr Tyr Gly Thr Arg Pro Ser Ile Gly Met Asp 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2

<400>  16

Ile Arg Ser Lys Ser Asn Asn Tyr Ala Ala 
1               5                   10  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3

<400>  17

Val Arg Asp Tyr Tyr Gly Thr Arg Pro Ser Ile Gly Met Asp Tyr 
1               5                   10                  15  


<210>  18
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   VL of antibody 118H1

<400>  18

Asp Ile Ala Met Thr Gln Ala Ala Pro Ser Val Phe Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Arg Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1

<400>  19

Gln Ser Leu Leu His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  20
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2

<400>  20

Leu Val Ser 
1           


<210>  21
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 170G6

<400>  21

Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asn 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Gly Val Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met Asp Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Asn Ser Leu Ser Trp Gly Pro Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1

<400>  22

Gly Tyr Thr Phe Thr Asp Asn Tyr 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2

<400>  23

Ile Asn Pro Tyr Asn Gly Val Thr 
1               5               


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3

<400>  24

Ser Asn Ser Leu Ser 
1               5   


<210>  25
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 170G6

<400>  25

Asp Val Val Met Thr Gln Ser Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Thr Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Thr 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Ile His Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1

<400>  26

Gln Ser Leu Leu Asp Thr Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3

<400>  27

Trp Gln Gly Ile His Tyr Pro Arg Thr 
1               5                   


<210>  28
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 172E7

<400>  28

Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asn 
            20                  25                  30          


Tyr Met Asn Trp Met Lys Gln Ser His Gly Lys Thr Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Gly Val Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Asn Ser Leu Ser Trp Gly Pro Gly Thr Ser Leu Thr Val Ser Ser 
            100                 105                 110         


<210>  29
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 172E7

<400>  29

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Ala Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Ile His Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Ile 
            100                 105                 110         


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1

<400>  30

Gln Ser Leu Val Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  31
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 84B4

<400>  31

Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Phe Thr Ile Thr Asp Tyr 
            20                  25                  30          


Tyr Phe Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asn Pro Tyr Asn Gly Val Ala Arg Tyr Lys Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Phe Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Phe Val Tyr Gly Thr Thr Tyr Asp Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1

<400>  32

Gly Phe Thr Ile Thr Asp Tyr Tyr 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2

<400>  33

Ile Asn Pro Tyr Asn Gly Val Ala 
1               5               


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3

<400>  34

Val Arg Phe Val Tyr Gly Thr Thr Tyr Asp Tyr Ala Met Asp Tyr 
1               5                   10                  15  


<210>  35
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 84B4

<400>  35

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Val Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1

<400>  36

Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  37
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2

<400>  37

Lys Val Ser 
1           


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3

<400>  38

Phe Gln Gly Ser His Val Pro Pro Thr 
1               5                   


<210>  39
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 2P15

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Ala Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Met Arg Ser Lys Ser Asn Tyr Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gln Thr Tyr Gly Ser Lys Asp Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1

<400>  40

Gly Phe Ser Phe Asn Ala Tyr Ala 
1               5               


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2

<400>  41

Met Arg Ser Lys Ser Asn Tyr Tyr Ala Thr 
1               5                   10  


<210>  42
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3

<400>  42

Val Arg Gln Thr Tyr Gly Ser Lys Asp Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  43
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 2P15

<400>  43

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Phe His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1

<400>  44

Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3

<400>  45

Ser Gln Ser Thr His Val Pro Phe Thr 
1               5                   


<210>  46
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 3C11

<400>  46

Glu Phe Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Asn Ile Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Asn His Gly Thr Thr Lys Ser Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asp Tyr Asp Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1

<400>  47

Gly Tyr Ser Phe Thr Asp Tyr Asn 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2

<400>  48

Ile Asn Pro Asn His Gly Thr Thr 
1               5               


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3

<400>  49

Ala Arg His Asp Tyr Asp Gly Ala Tyr 
1               5                   


<210>  50
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 3C11

<400>  50

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ile His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr Arg Ala Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1

<400>  51

Gln Ser Leu Ile His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  52
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2

<400>  52

Lys Ile Ser 
1           


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3

<400>  53

Ser Gln Ser Thr Arg Ala Pro Trp Thr 
1               5                   


<210>  54
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 3O20

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Ser Phe Asn Ala Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Thr Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Thr Leu Lys Thr Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gly Gly Tyr His Gly Asn Ser Ala Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  55
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3

<400>  55

Val Arg Gly Gly Tyr His Gly Asn Ser Ala Tyr Phe Asp Val 
1               5                   10                  


<210>  56
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 3O20

<400>  56

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  57
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 4M13

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Met Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gly Lys Asp Thr Ser Gly Ser Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Ser Val Ser Ser 
        115                 120             


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1

<400>  58

Gly Phe Ser Phe Asn Thr Tyr Ala 
1               5               


<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2

<400>  59

Met Arg Ser Lys Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  60
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3

<400>  60

Val Arg Gly Lys Asp Thr Ser Gly Ser Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  61
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 4M13

<400>  61

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro His Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Lys Val Glu Thr Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  62
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 2L15

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Ala Asp Ser Glu Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gly Lys Asp Ile Ser Val Ser Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  63
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3

<400>  63

Val Arg Gly Lys Asp Ile Ser Val Ser Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  64
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 2L15

<400>  64

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Gln His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Thr Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  65
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1

<400>  65

Lys Ser Leu Gln His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  66
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 4D24

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Pro Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gln Gly Trp Val Lys Arg Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  67
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3

<400>  67

Val Arg Gln Gly Trp Val Lys Arg Tyr Phe Asp Val 
1               5                   10          


<210>  68
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 4D24

<400>  68

Gly Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Gly Thr Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Thr Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1

<400>  69

Ser Ser Gly Thr Tyr 
1               5   


<210>  70
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2

<400>  70

Asp Thr Ser 
1           


<210>  71
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 1G17


<400>  71

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asp Tyr 
            20                  25                  30          
Glu Met His Trp Val Lys Gln Thr Pro Val Leu Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Arg Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Phe Lys Ala Thr Leu Thr Ala Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Arg Ala Tyr Trp Gly Gly Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         
Val Ser Ser 
        115 


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 of antibody 1G17


<400>  72
Gly Tyr Thr Phe Ala Asp Tyr Glu 
1               5               

<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 of antibody 1G17


<400>  73
Ile Asp Pro Glu Thr Gly Arg Thr 
1               5               

<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 of antibody 1G17


<400>  74
Thr Arg Arg Ala Tyr Trp Gly Gly 
1               5               

<210>  75
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 1G17


<400>  75
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Ser Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  76
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 of antibody 1G17


<400>  76
Gln Ser Leu Val His Ser Ser Gly Asn Thr Tyr 
1               5                   10      

<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 of antibody 1G17


<400>  77
Ser Gln Ser Thr His Val Pro Tyr Thr 
1               5                   

<210>  78
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 3F11


<400>  78
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Ser Asn Tyr Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Ser Met 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      
Tyr Cys Val Arg Gly Arg Glu Leu Gly Asp Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             

<210>  79
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 of antibody 3F11


<400>  79
Ile Arg Ser Lys Ser Asn Tyr Tyr Ala Thr 
1               5                   10  

<210>  80
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 of antibody 3F11


<400>  80
Val Arg Gly Arg Glu Leu Gly Asp Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  

<210>  81
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 3F11


<400>  81
Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asn Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      
Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  82
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 3F6


<400>  82
Glu Val Gln Phe Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Thr Lys Ser Asn Asn Tyr Ala Thr His Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Ile Val Ser Arg Asp Asp Ser Glu Asn Ile 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Gly Met Tyr 
                85                  90                  95      
Tyr Cys Val Arg Gly Gly Asn Gly Ile Tyr Gly Arg Asn Ala Met Asp 
            100                 105                 110         
Asn Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 

<210>  83
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 of antibody 3F6


<400>  83
Ile Arg Thr Lys Ser Asn Asn Tyr Ala Thr 
1               5                   10  

<210>  84
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 of antibody 3F6


<400>  84
Val Arg Gly Gly Asn Gly Ile Tyr Gly Arg Asn Ala Met Asp Asn 
1               5                   10                  15  

<210>  85
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 3F6


<400>  85
Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Ser Pro Gly 
1               5                   10                  15      
Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Ser Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      
Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  86
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 of antibody 3F6


<400>  86
Lys Ser Leu Leu His Ser Ser Gly Asn Thr Tyr 
1               5                   10      

<210>  87
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 4G19


<400>  87
Glu Val Gln Phe Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Thr Lys Ser Asn Asn Tyr Ala Thr His Tyr Ala Asp 
    50                  55                  60                  
Ser Val Thr Asp Arg Phe Ile Val Ser Arg Asp Asp Ser Glu Ser Met 
65                  70                  75                  80  
Thr Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Gly Met Tyr 
                85                  90                  95      
Tyr Cys Val Arg Gly Gly Asn Gly Ile Tyr Gly Arg Asn Thr Met Asp 
            100                 105                 110         
Asn Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 

<210>  88
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 of antibody 4G19


<400>  88
Val Arg Gly Gly Asn Gly Ile Tyr Gly Arg Asn Thr Met Asp Asn 
1               5                   10                  15  

<210>  89
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 4G19


<400>  89
Asp Ile Val Met Thr Gln Thr Ala Pro Ser Val Pro Val Ser Pro Gly 
1               5                   10                  15      
Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Ser Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      
Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Gln 
            100                 105                 110         

<210>  90
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 3F11hz1


<400>  90
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Arg Ile Arg Ser Lys Ser Asn Tyr Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Thr Arg Gly Arg Glu Leu Gly Asp Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210>  91
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 3F11hz1


<400>  91
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      
Leu Glu Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  92
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 3F11hz2, 3F11hz5 and 3F11hz6


<400>  92
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Arg Ile Arg Ser Lys Ser Asn Tyr Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg Gly Arg Glu Leu Gly Asp Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210>  93
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 3F11hz2


<400>  93
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asp Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      
Leu Glu Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  94
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 3F11hz3


<400>  94
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Arg Ile Arg Ser Lys Ser Asn Tyr Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg Gly Arg Glu Leu Gly Asp Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210>  95
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 3F11hz3


<400>  95
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asp Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      
Leu Glu Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  96
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 3F11hz4


<400>  96
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Arg Ile Arg Ser Lys Ser Asn Tyr Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg Gly Arg Glu Leu Gly Asp Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210>  97
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 3F11hz4


<400>  97
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      
Leu Glu Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  98
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 3F11hz5


<400>  98
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      
Leu Glu Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  99
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 3F11hz6


<400>  99
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Ser Gly Asn Thr Tyr Leu Asp Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      
Leu Glu Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  100
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 3O20hz1


<400>  100
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Ala Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Ala Tyr Ala Ala 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg Gly Gly Tyr His Gly Asn Ser Ala Tyr Phe Asp Val 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210>  101
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 3O20hz1


<400>  101
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln His 
                85                  90                  95      
Leu Glu Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  102
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 3O20hz2


<400>  102
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Ser Phe Asn Ala Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Thr Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg Gly Gly Tyr His Gly Asn Ser Ala Tyr Phe Asp Val 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210>  103
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 3O20hz2


<400>  103
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln His 
                85                  90                  95      
Leu Glu Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  104
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 3O20hz3


<400>  104
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Ser Phe Asn Ala Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Ala Tyr Ala Ala 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Thr Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg Gly Gly Tyr His Gly Asn Ser Ala Tyr Phe Asp Val 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210>  105
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 3O20hz3


<400>  105
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Gln Gly Asn Thr Tyr Leu Asp Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln His 
                85                  90                  95      
Leu Glu Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  106
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 1G17hz1


<400>  106
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asp Tyr 
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Arg Thr Ala Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg Ala Tyr Trp Gly Gly Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210>  107
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 1G17hz1


<400>  107
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Ser Gly Asn Thr Tyr Leu His Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      
Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  108
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 1G17hz2


<400>  108
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asp Tyr 
            20                  25                  30          
Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ile Ile Asp Pro Glu Thr Gly Arg Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Ala Thr Leu Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Arg Ala Tyr Trp Gly Gly Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210>  109
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 1G17hz2


<400>  109
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Ser Gly Asn Thr Tyr Leu Asn Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  110
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of antibody 1G17hz3


<400>  110
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asp Tyr 
            20                  25                  30          
Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Arg Thr Ala Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Arg Ala Tyr Trp Gly Gly Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210>  111
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of antibody 1G17hz3


<400>  111
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Ser Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110