                               SEQUENCE LISTING

<110> INSPIRAR LIMITED
 
<120> COMPOSITION AND METHODS FOR TREATING HEMOPHILIA B

<130> 57837-711.602

<140> PCT/CN2022/100382
<141> 2022-06-22

<150> PCT/CN2021/101845
<151> 2021-06-23

<160> 15    

<170> PatentIn version 3.5

<210> 1
<211> 461
<212> PRT
<213> Homo sapiens

<400> 1
Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210> 2
<211> 1386
<212> DNA
<213> Homo sapiens

<400> 2
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta       60

ggatatctac tcagtgctga atgtacagtt tttcttgatc atgaaaacgc caacaaaatt      120

ctgaatcggc caaagaggta taattcaggt aaattggaag agtttgttca agggaacctt      180

gagagagaat gtatggaaga aaagtgtagt tttgaagaag cacgagaagt ttttgaaaac      240

actgaaagaa caactgaatt ttggaagcag tatgttgatg gagatcagtg tgagtccaat      300

ccatgtttaa atggcggcag ttgcaaggat gacattaatt cctatgaatg ttggtgtccc      360

tttggatttg aaggaaagaa ctgtgaatta gatgtaacat gtaacattaa gaatggcaga      420

tgcgagcagt tttgtaaaaa tagtgctgat aacaaggtgg tttgctcctg tactgaggga      480

tatcgacttg cagaaaacca gaagtcctgt gaaccagcag tgccatttcc atgtggaaga      540

gtttctgttt cacaaacttc taagctcacc cgtgctgaga ctgtttttcc tgatgtggac      600

tatgtaaatt ctactgaagc tgaaaccatt ttggataaca tcactcaaag cacccaatca      660

tttaatgact tcactcgggt tgttggtgga gaagatgcca aaccaggtca attcccttgg      720

caggttgttt tgaatggtaa agttgatgca ttctgtggag gctctatcgt taatgaaaaa      780

tggattgtaa ctgctgccca ctgtgttgaa actggtgtta aaattacagt tgtcgcaggt      840

gaacataata ttgaggagac agaacataca gagcaaaagc gaaatgtgat tcgaattatt      900

cctcaccaca actacaatgc agctattaat aagtacaacc atgacattgc ccttctggaa      960

ctggacgaac ccttagtgct aaacagctac gttacaccta tttgcattgc tgacaaggaa     1020

tacacgaaca tcttcctcaa atttggatct ggctatgtaa gtggctgggg aagagtcttc     1080

cacaaaggga gatcagcttt agttcttcag taccttagag ttccacttgt tgaccgagcc     1140

acatgtcttc gatctacaaa gttcaccatc tataacaaca tgttctgtgc tggcttccat     1200

gaaggaggta gagattcatg tcaaggagat agtgggggac cccatgttac tgaagtggaa     1260

gggaccagtt tcttaactgg aattattagc tggggtgaag agtgtgcaat gaaaggcaaa     1320

tatggaatat ataccaaggt atcccggtat gtcaactgga ttaaggaaaa aacaaagctc     1380

acttaa                                                                1386


<210> 3
<211> 1386
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
atgcagaggg tcaacatgat tatggctgag agccctggcc tgatcaccat ctgtctgctg       60

ggctacctgc tgtctgcaga gtgcacagtg tttctggacc atgagaatgc caacaagatc      120

ctgaacaggc ccaagaggta caactctggc aagctggaag agtttgtgca gggcaacctg      180

gaaagggaat gcatggaaga gaagtgcagc tttgaagagg ccagggaagt gtttgagaac      240

acagagagaa ccacagagtt ctggaagcag tatgtggatg gggaccagtg tgaaagcaac      300

ccctgcctga atggtggcag ctgcaaggat gacatcaaca gctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgaactg gatgtgacct gcaacatcaa gaatggcaga      420

tgtgaacagt tctgcaagaa ctctgctgac aacaaggttg tgtgctcctg cacagagggc      480

tacagactgg ctgagaacca gaaaagctgt gaacctgctg tgccctttcc atgtggcaga      540

gtgtctgtgt cccagaccag caagctgacc agagctgagg ctgtgttccc tgatgtggac      600

tatgtgaact ccacagaggc tgagacaatc ctggacaaca tcacccagag cacccagtcc      660

ttcaatgact tcacaagagt tgttggaggg gaagatgcca agcctggaca gttcccttgg      720

caagtggtgc tgaatggcaa agtggatgcc ttctgtggtg gctccattgt gaatgagaag      780

tggattgtga cagctgccca ctgtgtggaa acaggggtca agatcacagt ggtggctggg      840

gagcacaaca ttgaggaaac agagcacaca gagcaaaaga ggaatgtcat caggatcatc      900

cctcaccaca actacaatgc tgccatcaac aagtacaacc atgacattgc cctgcttgag      960

ctggatgagc ccctggtcct gaactcctat gtgaccccta tctgcattgc tgacaaagag     1020

tacaccaaca tctttctgaa gtttggctct ggctatgtgt ctggctgggg tagagtgttc     1080

cacaagggaa gatctgccct ggtgctgcag tacctgagag tgcccctggt ggatagagcc     1140

acatgtctgc tgagcaccaa gttcaccatc tacaacaaca tgttctgtgc tgggttccat     1200

gaaggtggca gagactcctg ccagggagat agtggtggcc ctcatgtgac agaggtggaa     1260

ggcaccagct ttctgacagg catcatcagc tggggagaag agtgtgccat gaagggcaaa     1320

tatggcatct acaccaaggt gtccagatat gtcaactgga tcaaagaaaa gaccaagctc     1380

acctga                                                                1386


<210> 4
<211> 448
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      APO-HCR-hATT promoter sequence

<400> 4
ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct ccctgcctgc       60

tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac ctccaacatc      120

cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg tggtttaggt      180

agtgtgagag gggaatgact cctttcggta agtgcagtgg aagctgtaca ctgcccaggc      240

aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact tagcccctgt      300

ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct cccccgttgc      360

ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct cagcttcagg      420

caccaccact gacctgggac agtgaatc                                         448


<210> 5
<211> 727
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag      360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc      420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact      480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag      540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg      600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta      660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac      720

agtgaat                                                                727


<210> 6
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
gtaaatataa aatttttaag tgtataatgt gttaaactac tgattctaat tgtttctctc       60

ttttag                                                                  66


<210> 7
<211> 1438
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
gtttgtttcc ttttttataa tacattgagt atgcttgcct tttagatata gaaatatctg       60

attctgtctt cttcactaaa ttttgattac atgatttgac agcaatattg aagagtctaa      120

cagccagcac ccaggttggt aagtactggt tctttgttag ctaggttttc ttcttcttca      180

cttttaaaac taaatagatg gacaatgctt atgatgcaat aaggtttaat aaacactgtt      240

cagttcagta tttggtcatg taattcctgt taaaaaacag tcatctcctt ggtttaaaaa      300

aattaaaagt gggaaaacaa agaaatagca gaatatagtg aaaaaaaata accacagtat      360

ttttgtttgg acttaccact ttgaaatcaa attgggaaac aaaagcacaa acagtggcct      420

tatttacaca aaaagtctga ttttaagata tgtgacaatt caaggtttca gaagtatgta      480

aggaggtgtg tctctaattt tttaaattat atatcttcaa tttaaagttt tagttaaaac      540

ataaagatta acctttcatt agcaagctgt tagttatcac caaagctttt catggattag      600

gaaaaaatca ttttgtctct atctcaaaca tcttggagtt gatatttggg gaaacacaat      660

actcagttga gttccctagg ggagaaaagc aagcttaaga attgacacaa agagtaggaa      720

gttagctatt gcaacatata tcactttgtt ttttcacaac tacagtgact ttatttattt      780

cccagaggaa ggcatacagg gaagaaatta tcccatttgg acaaacagca tgttctcaca      840

gtaagcactt atcacactta cttgtcaact ttctagaatc aaatctagta gctgacagta      900

ccaggatcag gggtgccaac cctaagcacc cccagaaagc tgactggccc tgtggttccc      960

actccagaca tgatgtcagc tgtgaaatcc acctccctgg accataatta ggcttctgtt     1020

cttcaggaga catttgttca aagtcatttg ggcaaccata ttctgaaaac agcccagcca     1080

gggtgatgga tcactttgca aagatcctca atgagctatt ttcaagtgat gacaaagtgt     1140

gaagttaagg gctcatttga gaactttctt tttcatccaa agtaaattca aatatgatta     1200

gaaatctgac cttttattac tggaattctc ttgactaaaa gtaaaattga attttaattc     1260

ctaaatctcc atgtgtatac agtactgtgg gaacatcaca gattttggct ccatgcccta     1320

aagagaaatt ggctttcaga ttatttggat taaaaacaaa gactttctta agagatgtaa     1380

aattttcatg atgttttctt ttttgctaaa actaaagaat tattctttta catttcag       1438


<210> 8
<211> 134
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
atgctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa       60

taaacaagtt aacaacaaca attgcattca ttttatgttt caggttcagg gggaggtgtg      120

ggaggttttt taaa                                                        134


<210> 9
<211> 225
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccttgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcacattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctggggatg cagtgggctc tatgg                      225


<210> 10
<211> 2362
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg       60

acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagag agggagtggc      120

caactccatc actaggggtt cctggagggg tggagtcgtg acccctaaaa tgggcaaaca      180

ttgcaagcag caaacagcaa acacacagcc ctccctgcct gctgaccttg gagctggggc      240

agaggtcaga gacctctctg ggcccatgcc acctccaaca tccactcgac cccttggaat      300

ttcggtggag aggagcagag gttgtcctgg cgtggtttag gtagtgtgag aggggaatga      360

ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc cgggcagcgt      420

aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct ccgataactg      480

gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg atccactgct      540

taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca ctgacctggg      600

acagtgaatc cggactctaa ggtaaatata aaatttttaa gtgtataatg tgttaaacta      660

ctgattctaa ttgtttctct cttttagatt ccaacctttg gaactgaatt ctagaccacc      720

atgcagaggg tgaacatgat catggctgag agccctggcc tgatcaccat ctgcctgctg      780

ggctacctgc tgtctgctga gtgcactgtg ttcctggacc atgagaatgc caacaagatc      840

ctgaacaggc ccaagagata caactctggc aagctggagg agtttgtgca gggcaacctg      900

gagagggagt gcatggagga gaagtgcagc tttgaggagg ccagggaggt gtttgagaac      960

actgagagga ccactgagtt ctggaagcag tatgtggatg gggaccagtg tgagagcaac     1020

ccctgcctga atgggggcag ctgcaaggat gacatcaaca gctatgagtg ctggtgcccc     1080

tttggctttg agggcaagaa ctgtgagctg gatgtgacct gcaacatcaa gaatggcaga     1140

tgtgagcagt tctgcaagaa ctctgctgac aacaaggtgg tgtgcagctg cactgagggc     1200

tacaggctgg ctgagaacca gaagagctgt gagcctgctg tgccattccc atgtggcaga     1260

gtgtctgtga gccagaccag caagctgacc agggctgagg ctgtgttccc tgatgtggac     1320

tatgtgaaca gcactgaggc tgaaaccatc ctggacaaca tcacccagag cacccagagc     1380

ttcaatgact tcaccagggt ggtggggggg gaggatgcca agcctggcca gttcccctgg     1440

caagtggtgc tgaatggcaa ggtggatgcc ttctgtgggg gcagcattgt gaatgagaag     1500

tggattgtga ctgctgccca ctgtgtggag actggggtga agatcactgt ggtggctggg     1560

gagcacaaca ttgaggagac tgagcacact gagcagaaga ggaatgtgat caggatcatc     1620

ccccaccaca actacaatgc tgccatcaac aagtacaacc atgacattgc cctgctggag     1680

ctggatgagc ccctggtgct gaacagctat gtgaccccca tctgcattgc tgacaaggag     1740

tacaccaaca tcttcctgaa gtttggctct ggctatgtgt ctggctgggg cagggtgttc     1800

cacaagggca ggtctgccct ggtgctgcag tacctgaggg tgcccctggt ggacagggcc     1860

acctgcctgc tgagcaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1920

gaggggggca gggacagctg ccagggggac tctgggggcc cccatgtgac tgaggtggag     1980

ggcaccagct tcctgactgg catcatcagc tggggggagg agtgtgccat gaagggcaag     2040

tatggcatct acaccaaagt ctccagatat gtgaactgga tcaaggagaa gaccaagctg     2100

acctgactcg atgctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta     2160

taagctgcaa taaacaagtt aacaacaaca attgcattca ttttatgttt caggttcagg     2220

gggaggtgtg ggaggttttt taaactagtc cactccctct ctgcgcgctc gctcgctcac     2280

tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag     2340

cgagcgagcg cgcagagagg ga                                              2362


<210> 11
<211> 2365
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg       60

acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagag agggagtggc      120

caactccatc actaggggtt cctggagggg tggagtcgtg acccctaaaa tgggcaaaca      180

ttgcaagcag caaacagcaa acacacagcc ctccctgcct gctgaccttg gagctggggc      240

agaggtcaga gacctctctg ggcccatgcc acctccaaca tccactcgac cccttggaat      300

ttcggtggag aggagcagag gttgtcctgg cgtggtttag gtagtgtgag aggggaatga      360

ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc cgggcagcgt      420

aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct ccgataactg      480

gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg atccactgct      540

taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca ctgacctggg      600

acagtgaatc cggactctaa ggtaaatata aaatttttaa gtgtataatg tgttaaacta      660

ctgattctaa ttgtttctct cttttagatt ccaacctttg gaactgaatt ctagaccacc      720

atgcagaggg tcaacatgat tatggctgag agccctggcc tgatcaccat ctgtctgctg      780

ggctacctgc tgtctgcaga gtgcacagtg tttctggacc atgagaatgc caacaagatc      840

ctgaacaggc ccaagaggta caactctggc aagctggaag agtttgtgca gggcaacctg      900

gaaagggaat gcatggaaga gaagtgcagc tttgaagagg ccagggaagt gtttgagaac      960

acagagagaa ccacagagtt ctggaagcag tatgtggatg gggaccagtg tgaaagcaac     1020

ccctgcctga atggtggcag ctgcaaggat gacatcaaca gctatgagtg ctggtgcccc     1080

tttggctttg agggcaagaa ctgtgaactg gatgtgacct gcaacatcaa gaatggcaga     1140

tgtgaacagt tctgcaagaa ctctgctgac aacaaggttg tgtgctcctg cacagagggc     1200

tacagactgg ctgagaacca gaaaagctgt gaacctgctg tgccctttcc atgtggcaga     1260

gtgtctgtgt cccagaccag caagctgacc agagctgagg ctgtgttccc tgatgtggac     1320

tatgtgaact ccacagaggc tgagacaatc ctggacaaca tcacccagag cacccagtcc     1380

ttcaatgact tcacaagagt tgttggaggg gaagatgcca agcctggaca gttcccttgg     1440

caagtggtgc tgaatggcaa agtggatgcc ttctgtggtg gctccattgt gaatgagaag     1500

tggattgtga cagctgccca ctgtgtggaa acaggggtca agatcacagt ggtggctggg     1560

gagcacaaca ttgaggaaac agagcacaca gagcaaaaga ggaatgtcat caggatcatc     1620

cctcaccaca actacaatgc tgccatcaac aagtacaacc atgacattgc cctgcttgag     1680

ctggatgagc ccctggtcct gaactcctat gtgaccccta tctgcattgc tgacaaagag     1740

tacaccaaca tctttctgaa gtttggctct ggctatgtgt ctggctgggg tagagtgttc     1800

cacaagggaa gatctgccct ggtgctgcag tacctgagag tgcccctggt ggatagagcc     1860

acatgtctgc tgagcaccaa gttcaccatc tacaacaaca tgttctgtgc tgggttccat     1920

gaaggtggca gagactcctg ccagggagat agtggtggcc ctcatgtgac agaggtggaa     1980

ggcaccagct ttctgacagg catcatcagc tggggagaag agtgtgccat gaagggcaaa     2040

tatggcatct acaccaaggt gtccagatat gtcaactgga tcaaagaaaa gaccaagctc     2100

acctgatgac tcgatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca     2160

ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc     2220

agggggaggt gtgggaggtt ttttaaacta gtccactccc tctctgcgcg ctcgctcgct     2280

cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt     2340

gagcgagcga gcgcgcagag aggga                                           2365


<210> 12
<211> 2386
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
ggcagctgcg cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg cgtcgggcga       60

cctttggtcg cccggcctca gtgagcgagc gagcgcgcag agagggagtg gccaactcca      120

tcactagggg ttcctgaatt cactagtgag ctcccctaaa atgggcaaac attgcaagca      180

gcaaacagca aacacacagc cctccctgcc tgctgacctt ggagctgggg cagaggtcag      240

agacctctct gggcccatgc cacctccaac atccactcga ccccttggaa tttcggtgga      300

gaggagcaga ggttgtcctg gcgtggttta ggtagtgtga gaggggaatg actcctttcg      360

gtaagtgcag tggaagctgt acactgccca ggcaaagcgt ccgggcagcg taggcgggcg      420

actcagatcc cagccagtgg acttagcccc tgtttgctcc tccgataact ggggtgacct      480

tggttaatat tcaccagcag cctcccccgt tgcccctctg gatccactgc ttaaatacgg      540

acgaggacag ggccctgtct cctcagcttc aggcaccacc actgacctgg gacagtgaat      600

ccggactcta aggtaaatat aaaattttta agtgtataat gtgttaaact actgattcta      660

attgtttctc tcttttagat tccaaccttt ggaactgaat tctagaccac catgcagagg      720

gtgaacatga tcatggctga gagccctggc ctgatcacca tctgcctgct gggctacctg      780

ctgtctgctg agtgcactgt gttcctggac catgagaatg ccaacaagat cctgaacagg      840

cccaagagat acaactctgg caagctggag gagtttgtgc agggcaacct ggagagggag      900

tgcatggagg agaagtgcag ctttgaggag gccagggagg tgtttgagaa cactgagagg      960

accactgagt tctggaagca gtatgtggat ggggaccagt gtgagagcaa cccctgcctg     1020

aatgggggca gctgcaagga tgacatcaac agctatgagt gctggtgccc ctttggcttt     1080

gagggcaaga actgtgagct ggatgtgacc tgcaacatca agaatggcag atgtgagcag     1140

ttctgcaaga actctgctga caacaaggtg gtgtgcagct gcactgaggg ctacaggctg     1200

gctgagaacc agaagagctg tgagcctgct gtgccattcc catgtggcag agtgtctgtg     1260

agccagacca gcaagctgac cagggctgag gctgtgttcc ctgatgtgga ctatgtgaac     1320

agcactgagg ctgaaaccat cctggacaac atcacccaga gcacccagag cttcaatgac     1380

ttcaccaggg tggtgggggg ggaggatgcc aagcctggcc agttcccctg gcaagtggtg     1440

ctgaatggca aggtggatgc cttctgtggg ggcagcattg tgaatgagaa gtggattgtg     1500

actgctgccc actgtgtgga gactggggtg aagatcactg tggtggctgg ggagcacaac     1560

attgaggaga ctgagcacac tgagcagaag aggaatgtga tcaggatcat cccccaccac     1620

aactacaatg ctgccatcaa caagtacaac catgacattg ccctgctgga gctggatgag     1680

cccctggtgc tgaacagcta tgtgaccccc atctgcattg ctgacaagga gtacaccaac     1740

atcttcctga agtttggctc tggctatgtg tctggctggg gcagggtgtt ccacaagggc     1800

aggtctgccc tggtgctgca gtacctgagg gtgcccctgg tggacagggc cacctgcctg     1860

ctgagcacca agttcaccat ctacaacaac atgttctgtg ctggcttcca tgaggggggc     1920

agggacagct gccaggggga ctctgggggc ccccatgtga ctgaggtgga gggcaccagc     1980

ttcctgactg gcatcatcag ctggggggag gagtgtgcca tgaagggcaa gtatggcatc     2040

tacaccaaag tctccagata tgtgaactgg atcaaggaga agaccaagct gacctgactc     2100

gatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca     2160

ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag ggggaggtgt     2220

gggaggtttt ttaaattcga atctagaagg aacccctagt gatggagttg gccactccct     2280

ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct     2340

ttgcccgggc ggcctcagtg agcgagcgag cgcgcagctg cctgca                    2386


<210> 13
<211> 2389
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
ggcagctgcg cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg cgtcgggcga       60

cctttggtcg cccggcctca gtgagcgagc gagcgcgcag agagggagtg gccaactcca      120

tcactagggg ttcctgaatt cactagtgag ctcccctaaa atgggcaaac attgcaagca      180

gcaaacagca aacacacagc cctccctgcc tgctgacctt ggagctgggg cagaggtcag      240

agacctctct gggcccatgc cacctccaac atccactcga ccccttggaa tttcggtgga      300

gaggagcaga ggttgtcctg gcgtggttta ggtagtgtga gaggggaatg actcctttcg      360

gtaagtgcag tggaagctgt acactgccca ggcaaagcgt ccgggcagcg taggcgggcg      420

actcagatcc cagccagtgg acttagcccc tgtttgctcc tccgataact ggggtgacct      480

tggttaatat tcaccagcag cctcccccgt tgcccctctg gatccactgc ttaaatacgg      540

acgaggacag ggccctgtct cctcagcttc aggcaccacc actgacctgg gacagtgaat      600

ccggactcta aggtaaatat aaaattttta agtgtataat gtgttaaact actgattcta      660

attgtttctc tcttttagat tccaaccttt ggaactgaat tctagaccac catgcagagg      720

gtcaacatga ttatggctga gagccctggc ctgatcacca tctgtctgct gggctacctg      780

ctgtctgcag agtgcacagt gtttctggac catgagaatg ccaacaagat cctgaacagg      840

cccaagaggt acaactctgg caagctggaa gagtttgtgc agggcaacct ggaaagggaa      900

tgcatggaag agaagtgcag ctttgaagag gccagggaag tgtttgagaa cacagagaga      960

accacagagt tctggaagca gtatgtggat ggggaccagt gtgaaagcaa cccctgcctg     1020

aatggtggca gctgcaagga tgacatcaac agctatgagt gctggtgccc ctttggcttt     1080

gagggcaaga actgtgaact ggatgtgacc tgcaacatca agaatggcag atgtgaacag     1140

ttctgcaaga actctgctga caacaaggtt gtgtgctcct gcacagaggg ctacagactg     1200

gctgagaacc agaaaagctg tgaacctgct gtgccctttc catgtggcag agtgtctgtg     1260

tcccagacca gcaagctgac cagagctgag gctgtgttcc ctgatgtgga ctatgtgaac     1320

tccacagagg ctgagacaat cctggacaac atcacccaga gcacccagtc cttcaatgac     1380

ttcacaagag ttgttggagg ggaagatgcc aagcctggac agttcccttg gcaagtggtg     1440

ctgaatggca aagtggatgc cttctgtggt ggctccattg tgaatgagaa gtggattgtg     1500

acagctgccc actgtgtgga aacaggggtc aagatcacag tggtggctgg ggagcacaac     1560

attgaggaaa cagagcacac agagcaaaag aggaatgtca tcaggatcat ccctcaccac     1620

aactacaatg ctgccatcaa caagtacaac catgacattg ccctgcttga gctggatgag     1680

cccctggtcc tgaactccta tgtgacccct atctgcattg ctgacaaaga gtacaccaac     1740

atctttctga agtttggctc tggctatgtg tctggctggg gtagagtgtt ccacaaggga     1800

agatctgccc tggtgctgca gtacctgaga gtgcccctgg tggatagagc cacatgtctg     1860

ctgagcacca agttcaccat ctacaacaac atgttctgtg ctgggttcca tgaaggtggc     1920

agagactcct gccagggaga tagtggtggc cctcatgtga cagaggtgga aggcaccagc     1980

tttctgacag gcatcatcag ctggggagaa gagtgtgcca tgaagggcaa atatggcatc     2040

tacaccaagg tgtccagata tgtcaactgg atcaaagaaa agaccaagct cacctgatga     2100

ctcgatgctt tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct     2160

gcaataaaca agttaacaac aacaattgca ttcattttat gtttcaggtt cagggggagg     2220

tgtgggaggt tttttaaatt cgaatctaga aggaacccct agtgatggag ttggccactc     2280

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     2340

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag ctgcctgca                 2389


<210> 14
<211> 4200
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 14
ggcagctgcg cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg cgtcgggcga       60

cctttggtcg cccggcctca gtgagcgagc gagcgcgcag agagggagtg gccaactcca      120

tcactagggg ttcctgaatt cactagtgag ctcaggctca gaggcacaca ggagtttctg      180

ggctcaccct gcccccttcc aacccctcag ttcccatcct ccagcagctg tttgtgtgct      240

gcctctgaag tccacactga acaaacttca gcctactcat gtccctaaaa tgggcaaaca      300

ttgcaagcag caaacagcaa acacacagcc ctccctgcct gctgaccttg gagctggggc      360

agaggtcaga gacctctctg ggcccatgcc acctccaaca tccactcgac cccttggaat      420

ttcggtggag aggagcagag gttgtcctgg cgtggtttag gtagtgtgag aggggtaccc      480

ggggatcttg ctaccagtgg aacagccact aaggattctg cagtgagagc agagggccag      540

ctaagtggta ctctcccaga gactgtctga ctcacgccac cccctccacc ttggacacag      600

gacgctgtgg tttctgagcc aggtacaatg actcctttcg gtaagtgcag tggaagctgt      660

acactgccca ggcaaagcgt ccgggcagcg taggcgggcg actcagatcc cagccagtgg      720

acttagcccc tgtttgctcc tccgataact ggggtgacct tggttaatat tcaccagcag      780

cctcccccgt tgcccctctg gatccactgc ttaaatacgg acgaggacag ggccctgtct      840

cctcagcttc aggcaccacc actgacctgg gacagtgaat accactttca caatctgcta      900

gcaaaggtta tgcagagggt gaacatgatc atggctgaga gccctggcct gatcaccatc      960

tgcctgctgg gctacctgct gtctgctgaa tgtacaggtt tgtttccttt tttataatac     1020

attgagtatg cttgcctttt agatatagaa atatctgatt ctgtcttctt cactaaattt     1080

tgattacatg atttgacagc aatattgaag agtctaacag ccagcaccca ggttggtaag     1140

tactggttct ttgttagcta ggttttcttc ttcttcactt ttaaaactaa atagatggac     1200

aatgcttatg atgcaataag gtttaataaa cactgttcag ttcagtattt ggtcatgtaa     1260

ttcctgttaa aaaacagtca tctccttggt ttaaaaaaat taaaagtggg aaaacaaaga     1320

aatagcagaa tatagtgaaa aaaaataacc acagtatttt tgtttggact taccactttg     1380

aaatcaaatt gggaaacaaa agcacaaaca gtggccttat ttacacaaaa agtctgattt     1440

taagatatgt gacaattcaa ggtttcagaa gtatgtaagg aggtgtgtct ctaatttttt     1500

aaattatata tcttcaattt aaagttttag ttaaaacata aagattaacc tttcattagc     1560

aagctgttag ttatcaccaa agcttttcat ggattaggaa aaaatcattt tgtctctatc     1620

tcaaacatct tggagttgat atttggggaa acacaatact cagttgagtt ccctagggga     1680

gaaaagcaag cttaagaatt gacacaaaga gtaggaagtt agctattgca acatatatca     1740

ctttgttttt tcacaactac agtgacttta tttatttccc agaggaaggc atacagggaa     1800

gaaattatcc catttggaca aacagcatgt tctcacagta agcacttatc acacttactt     1860

gtcaactttc tagaatcaaa tctagtagct gacagtacca ggatcagggg tgccaaccct     1920

aagcaccccc agaaagctga ctggccctgt ggttcccact ccagacatga tgtcagctgt     1980

gaaatccacc tccctggacc ataattaggc ttctgttctt caggagacat ttgttcaaag     2040

tcatttgggc aaccatattc tgaaaacagc ccagccaggg tgatggatca ctttgcaaag     2100

atcctcaatg agctattttc aagtgatgac aaagtgtgaa gttaagggct catttgagaa     2160

ctttcttttt catccaaagt aaattcaaat atgattagaa atctgacctt ttattactgg     2220

aattctcttg actaaaagta aaattgaatt ttaattccta aatctccatg tgtatacagt     2280

actgtgggaa catcacagat tttggctcca tgccctaaag agaaattggc tttcagatta     2340

tttggattaa aaacaaagac tttcttaaga gatgtaaaat tttcatgatg ttttcttttt     2400

tgctaaaact aaagaattat tcttttacat ttcagttttt cttgatcatg aaaatgccaa     2460

caaaattctg aatagaccaa agaggtataa ctctggcaag cttgaagagt ttgtacaggg     2520

gaatctggag agagagtgta tggaagagaa gtgcagcttt gaggaagcca gagaagtgtt     2580

tgaaaataca gagagaacaa ctgaattttg gaagcagtat gtggatggtg atcaatgtga     2640

gagcaatccc tgcttgaatg gggggagctg taaagatgat atcaacagct atgaatgttg     2700

gtgtcccttt ggatttgagg ggaaaaactg tgagcttgat gtgacctgta atatcaagaa     2760

tggcaggtgt gagcaatttt gcaagaattc tgctgataac aaagtggtct gtagctgcac     2820

tgagggatat aggctggctg aaaaccagaa gagctgtgaa cctgcagtgc cttttccctg     2880

tgggagagtg tctgtgagcc aaaccagcaa gctgactagg gctgaagcag tctttcctga     2940

tgtagattat gtgaatagca ctgaggctga gacaatcctt gacaatatca ctcagagcac     3000

acagagcttc aatgacttca ccagggtggt aggaggggag gatgccaagc ctgggcagtt     3060

cccctggcag gtagtgctca atggaaaagt ggatgccttt tgtggaggtt caattgtaaa     3120

tgagaagtgg attgtgactg cagcccactg tgtggaaact ggagtcaaga ttactgtggt     3180

ggctggagag cacaatattg aggaaactga gcacactgag cagaagagga atgtgatcag     3240

gattatcccc caccacaact acaatgctgc tatcaacaag tacaaccatg acattgccct     3300

cctggaactg gatgaacccc tggtcttgaa cagctatgtg acacccatct gtattgctga     3360

taaagagtac accaacatct tcttgaaatt tgggtctgga tatgtgtctg gctggggcag     3420

ggtgttccat aaaggcaggt ctgccctggt attgcagtat ttgagggtgc ctctggtgga     3480

tagagcaacc tgcttgctga gcaccaagtt tacaatctac aacaatatgt tctgtgcagg     3540

gttccatgaa ggtggtagag acagctgcca gggagattct gggggtcccc atgtgactga     3600

ggtggaggga accagcttcc tgactgggat tatcagctgg ggtgaggagt gtgctatgaa     3660

gggaaagtat gggatctaca caaaagtatc cagatatgtg aactggatta aggagaaaac     3720

caagctgact tgatgaaaga tggatttcca aggttaattc attggaattg aaaattaaca     3780

gagatctaga gctgaattcc tgcagccagg gggatcagcc tctactgtgc cttctagttg     3840

ccagccatct gttgtttgcc cctccccctt gccttccttg accctggaag gtgccactcc     3900

cactgtcctt tcctaataaa atgaggaaat tgcatcacat tgtctgagta ggtgtcattc     3960

tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag     4020

gcatgctggg gatgcagtgg gctctatggt tcgaatctag aaggaacccc tagtgatgga     4080

gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc     4140

ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gctgcctgca     4200


<210> 15
<211> 4208
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgaattcact agtgagctca ggctcagagg cacacaggag      180

tttctgggct caccctgccc ccttccaacc cctcagttcc catcctccag cagctgtttg      240

tgtgctgcct ctgaagtcca cactgaacaa acttcagcct actcatgtcc ctaaaatggg      300

caaacattgc aagcagcaaa cagcaaacac acagccctcc ctgcctgctg accttggagc      360

tggggcagag gtcagagacc tctctgggcc catgccacct ccaacatcca ctcgacccct      420

tggaatttcg gtggagagga gcagaggttg tcctggcgtg gtttaggtag tgtgagaggg      480

gtacccgggg atcttgctac cagtggaaca gccactaagg attctgcagt gagagcagag      540

ggccagctaa gtggtactct cccagagact gtctgactca cgccaccccc tccaccttgg      600

acacaggacg ctgtggtttc tgagccaggt acaatgactc ctttcggtaa gtgcagtgga      660

agctgtacac tgcccaggca aagcgtccgg gcagcgtagg cgggcgactc agatcccagc      720

cagtggactt agcccctgtt tgctcctccg ataactgggg tgaccttggt taatattcac      780

cagcagcctc ccccgttgcc cctctggatc cactgcttaa atacggacga ggacagggcc      840

ctgtctcctc agcttcaggc accaccactg acctgggaca gtgaatacca ctttcacaat      900

ctgctagcaa aggttatgca gagggtcaac atgattatgg ctgagagccc tggcctgatc      960

accatctgtc tgctgggcta cctgctgtct gcagagtgca caggtttgtt tcctttttta     1020

taatacattg agtatgcttg ccttttagat atagaaatat ctgattctgt cttcttcact     1080

aaattttgat tacatgattt gacagcaata ttgaagagtc taacagccag cacccaggtt     1140

ggtaagtact ggttctttgt tagctaggtt ttcttcttct tcacttttaa aactaaatag     1200

atggacaatg cttatgatgc aataaggttt aataaacact gttcagttca gtatttggtc     1260

atgtaattcc tgttaaaaaa cagtcatctc cttggtttaa aaaaattaaa agtgggaaaa     1320

caaagaaata gcagaatata gtgaaaaaaa ataaccacag tatttttgtt tggacttacc     1380

actttgaaat caaattggga aacaaaagca caaacagtgg ccttatttac acaaaaagtc     1440

tgattttaag atatgtgaca attcaaggtt tcagaagtat gtaaggaggt gtgtctctaa     1500

ttttttaaat tatatatctt caatttaaag ttttagttaa aacataaaga ttaacctttc     1560

attagcaagc tgttagttat caccaaagct tttcatggat taggaaaaaa tcattttgtc     1620

tctatctcaa acatcttgga gttgatattt ggggaaacac aatactcagt tgagttccct     1680

aggggagaaa agcaagctta agaattgaca caaagagtag gaagttagct attgcaacat     1740

atatcacttt gttttttcac aactacagtg actttattta tttcccagag gaaggcatac     1800

agggaagaaa ttatcccatt tggacaaaca gcatgttctc acagtaagca cttatcacac     1860

ttacttgtca actttctaga atcaaatcta gtagctgaca gtaccaggat caggggtgcc     1920

aaccctaagc acccccagaa agctgactgg ccctgtggtt cccactccag acatgatgtc     1980

agctgtgaaa tccacctccc tggaccataa ttaggcttct gttcttcagg agacatttgt     2040

tcaaagtcat ttgggcaacc atattctgaa aacagcccag ccagggtgat ggatcacttt     2100

gcaaagatcc tcaatgagct attttcaagt gatgacaaag tgtgaagtta agggctcatt     2160

tgagaacttt ctttttcatc caaagtaaat tcaaatatga ttagaaatct gaccttttat     2220

tactggaatt ctcttgacta aaagtaaaat tgaattttaa ttcctaaatc tccatgtgta     2280

tacagtactg tgggaacatc acagattttg gctccatgcc ctaaagagaa attggctttc     2340

agattatttg gattaaaaac aaagactttc ttaagagatg taaaattttc atgatgtttt     2400

cttttttgct aaaactaaag aattattctt ttacatttca gtgtttctgg accatgagaa     2460

tgccaacaag atcctgaaca ggcccaagag gtacaactct ggcaagctgg aagagtttgt     2520

gcagggcaac ctggaaaggg aatgcatgga agagaagtgc agctttgaag aggccaggga     2580

agtgtttgag aacacagaga gaaccacaga gttctggaag cagtatgtgg atggggacca     2640

gtgtgaaagc aacccctgcc tgaatggtgg cagctgcaag gatgacatca acagctatga     2700

gtgctggtgc ccctttggct ttgagggcaa gaactgtgaa ctggatgtga cctgcaacat     2760

caagaatggc agatgtgaac agttctgcaa gaactctgct gacaacaagg ttgtgtgctc     2820

ctgcacagag ggctacagac tggctgagaa ccagaaaagc tgtgaacctg ctgtgccctt     2880

tccatgtggc agagtgtctg tgtcccagac cagcaagctg accagagctg aggctgtgtt     2940

ccctgatgtg gactatgtga actccacaga ggctgagaca atcctggaca acatcaccca     3000

gagcacccag tccttcaatg acttcacaag agttgttgga ggggaagatg ccaagcctgg     3060

acagttccct tggcaagtgg tgctgaatgg caaagtggat gccttctgtg gtggctccat     3120

tgtgaatgag aagtggattg tgacagctgc ccactgtgtg gaaacagggg tcaagatcac     3180

agtggtggct ggggagcaca acattgagga aacagagcac acagagcaaa agaggaatgt     3240

catcaggatc atccctcacc acaactacaa tgctgccatc aacaagtaca accatgacat     3300

tgccctgctt gagctggatg agcccctggt cctgaactcc tatgtgaccc ctatctgcat     3360

tgctgacaaa gagtacacca acatctttct gaagtttggc tctggctatg tgtctggctg     3420

gggtagagtg ttccacaagg gaagatctgc cctggtgctg cagtacctga gagtgcccct     3480

ggtggataga gccacatgtc tgctgagcac caagttcacc atctacaaca acatgttctg     3540

tgctgggttc catgaaggtg gcagagactc ctgccaggga gatagtggtg gccctcatgt     3600

gacagaggtg gaaggcacca gctttctgac aggcatcatc agctggggag aagagtgtgc     3660

catgaagggc aaatatggca tctacaccaa ggtgtccaga tatgtcaact ggatcaaaga     3720

aaagaccaag ctcacctgat gaaagatgga tttccaaggt taattcattg gaattgaaaa     3780

ttaacagaga tctagagctg aattcctgca gccaggggga tcagcctcta ctgtgccttc     3840

tagttgccag ccatctgttg tttgcccctc ccccttgcct tccttgaccc tggaaggtgc     3900

cactcccact gtcctttcct aataaaatga ggaaattgca tcacattgtc tgagtaggtg     3960

tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa     4020

tagcaggcat gctggggatg cagtgggctc tatggttcga atctagaagg aacccctagt     4080

gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa     4140

ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagctg     4200

cctgcagg                                                              4208


