                         SEQUENCE LISTING

<110>  SUNNYBROOK RESEARCH INSTITUTE
 
<120>  VISTA AGONISTS AND RELATED COMPOSITIONS AND METHODS

<130>  16481-9 (174529) ELL

<150>  US 63/215076
<151>  2021-06-25

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nb7 CDR1

<400>  1

Ala Phe Thr Asn Ala Tyr Met Asn 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nb7 CDR2

<400>  2

Thr Arg Asp Ser Asn Arg Thr Ser 
1               5               


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nb7 CDR3

<400>  3

Ala Glu Pro Ser Gly Trp Trp Leu Asp Asp Asp Tyr Trp 
1               5                   10              


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7E12 CDR1

<400>  4

Gly Tyr Ser Ile Thr Ser Gly Tyr Tyr 
1               5                   


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7E12 CDR2

<400>  5

Ile Ser Tyr Asp Gly Asn Asn 
1               5           


<210>  6
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7E12 CDR3

<400>  6

Ala Arg Gly Asp Tyr Gly Ser Glu Ala Met Asp Tyr 
1               5                   10          


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7G5 CDR1

<400>  7

Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7G5 CDR2

<400>  8

Ile Asn Thr Tyr Thr Gly Glu Pro 
1               5               


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7G5 CDR3

<400>  9

Ala Arg Arg Ser Asn Pro Trp Pro Asn Asp Tyr 
1               5                   10      


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3C3 CDR1

<400>  10

Gly Phe Asn Ile Arg Asn Thr Tyr 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3C3 CDR2

<400>  11

Ile Asp Pro Ala Asn Gly Asn Thr 
1               5               


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3C3 CDR3

<400>  12

Ile Met His Ala Glu Gly Gln Gly Trp Phe Ala Tyr 
1               5                   10          


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7C6 CDR1

<400>  13

Gly Tyr Thr Phe Thr Ser Tyr Tyr 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7C6 CDR2

<400>  14

Ile Asn Thr Gly Ser Gly Gly Thr 
1               5               


<210>  15
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7C6 CDR3

<400>  15

Ala Arg Glu Gly Thr Phe Tyr Ser Gly Asp Val Gly Tyr Trp Tyr Phe 
1               5                   10                  15      


Asp Phe 
        


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7C7 CDR1

<400>  16

Gly Phe Thr Phe Asn Lys Tyr Trp 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7C7 CDR2

<400>  17

Ile Thr Asn Ser Gly Gly Asn Thr 
1               5               


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7C7 CDR3

<400>  18

Thr Leu Gly Val Asp Tyr 
1               5       


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7G1 CDR1

<400>  19

Gly Leu Ser Leu Thr Ser Asn Ser 
1               5               


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7G1 CDR2

<400>  20

Ile Trp Ser Asn Gly Gly Thr 
1               5           


<210>  21
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7G1 CDR3

<400>  21

Ala Arg Tyr Tyr Asp Gly Ser Tyr Tyr Trp Tyr Phe Asp Phe 
1               5                   10                  


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G10 CDR1

<400>  22

Gly Tyr Thr Phe Thr Asp Tyr Glu 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G10 CDR2

<400>  23

Ile Asp Pro Glu Thr Gly Gly Thr 
1               5               


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G10 CDR3

<400>  24

Thr Arg Trp Ser Leu Arg Pro Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  25
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7E12 Heavy Chain

<400>  25

Asp Val His Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Asp Gly Asn Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Gly Ser Glu Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  26
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7E12 Light Chain

<400>  26

Asp Ile Arg Val Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Ile Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  27
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7G5 Heavy Chain

<400>  27

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Glu Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Ser Asn Pro Trp Pro Asn Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Leu Thr Val Ser Ser 
        115             


<210>  28
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7G5 Light Chain

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  29
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3C3 Heavy Chain

<400>  29

Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Gly Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Val Ser Gly Phe Asn Ile Arg Asn Thr 
            20                  25                  30          


Tyr Met His Trp Val Asn Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Ile Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Val Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Gln Leu Lys Ser Asp Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ile Met His Ala Glu Gly Gln Gly Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  30
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3C3 Light Chain

<400>  30

Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
1               5                   10                  15      


Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser Val Ser Thr Ser Gly 
            20                  25                  30          


Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro Gly Gln Pro Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro 
65                  70                  75                  80  


Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ile Arg Glu 
                85                  90                  95      


Leu Thr Arg Ser Glu Gly Gly Pro Ser Trp Lys 
            100                 105         


<210>  31
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7C6 Heavy Chain

<400>  31

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile Ser Trp Ile Lys Gln Thr Thr Gly Gln Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Tyr Ile Asn Thr Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Phe Tyr Ser Gly Asp Val Gly Tyr Trp Tyr Phe 
            100                 105                 110         


Asp Phe Trp Gly Pro Gly Ser Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  32
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7C7 Heavy Chain

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Trp Met Ser Trp Thr Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr Asn Ser Gly Gly Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Leu Gly Val Asp Tyr Trp Gly Gln Gly Ala Met Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  33
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7C7 Light Chain

<400>  33

Asp Val Val Met Thr Gln Thr Pro Pro Ser Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Ser Val Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu His Trp Leu Leu Gln Ser Ser Gly Arg Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Gln Val Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Thr Gly Ser Gln Lys Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Lys Asp Leu Gly Val Tyr Tyr Cys Ala Gln Thr 
                85                  90                  95      


Thr His Phe Pro Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Met Lys 
            100                 105                 110         


<210>  34
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7G1 Heavy Chain

<400>  34

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Leu Ser Leu Thr Ser Asn 
            20                  25                  30          


Ser Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile Trp Ser Asn Gly Gly Thr Asp Tyr Asn Ser Ala Ile Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Val Asn Ser Leu Gln Thr Glu Asp Ala Met Tyr Phe Cys Ala Arg 
                85                  90                  95      


Tyr Tyr Asp Gly Ser Tyr Tyr Trp Tyr Phe Asp Phe Trp Gly Pro Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  35
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7G1 Light Chain

<400>  35

Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
1               5                   10                  15      


Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser Val Ser Thr Ser Gly 
            20                  25                  30          


Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro Gly Gln Pro Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro 
65                  70                  75                  80  


Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ile Arg Glu 
                85                  90                  95      


Leu Thr Arg Ser Glu Gly Gly Pro Ser Trp Lys 
            100                 105         


<210>  36
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G10 Heavy Chain

<400>  36

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Ser Leu Arg Pro Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  37
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G10 Light Chain

<400>  37

Asp Val Val Met Thr His Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Asn 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  38
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nb7

<400>  38

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Tyr Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ala Phe Thr Asn Ala 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Ala Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Arg Asp Ser Asn Arg Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Ser Asp Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Asn Ala Glu Pro Ser Gly Trp Trp Leu Asp Asp Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


