                         SEQUENCE LISTING

<110>  THE UNIVERSITY OF BRITISH COLUMBIA
       SIMON FRASER UNIVERSITY
       KIZHAKKEDATHU, Jayachandran
       ENNS, Winnie
       DU, Caigan
       WITHERS, Stephen
       LUO, Haiming
       CHOY, Jonathan
       SIREN, Erika
 
<120>  CELL-SURFACE ENGINEERING COMPOSITIONS AND METHODS FOR THE 
       PREVENTION OF IMMUNE REJECTION

<130>  P2111PC00

<150>  63/213,322
<151>  2021-06-22

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Tag Sequence

<400>  1

Gly Gln Gln Gln Leu Gly 
1               5       


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Tag Sequence

<400>  2

Gly Gln Gln Gln Leu Gly Gly Gly Gly 
1               5                   


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Tag Sequence

<400>  3

Gly Gln Gln Gln Leu Gly Gly Gly Gly Gly 
1               5                   10  


<210>  4
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Tag Sequence

<400>  4

Gly Gln Gln Gln Leu Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Tag Sequence

<400>  5

Trp Leu Ala Gln Arg Pro His 
1               5           


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Tag Sequence

<400>  6

Pro Lys Pro Gln Gln Phe Met 
1               5           


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Tag Sequence

<400>  7

Gly Gln Leu Lys His Leu Glu Gln Gln Glu Gly 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Tag Sequence

<400>  8

Pro Asn Pro Gln Leu Pro Phe 
1               5           


<210>  9
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Tag Sequence

<400>  9

Asn Gln Glu Gln Val Ser Pro Leu Thr Leu Leu Lys 
1               5                   10          


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Tag Sequence

<400>  10

Thr Val Gln Gln Glu Leu 
1               5       


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Tag Sequence

<400>  11

Gln Val Pro Leu 
1               


<210>  12
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Tag Sequence

<400>  12

Asn Gly Leu 
1           


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Tag Sequence

<400>  13

Leu Pro Glu Thr Gly 
1               5   


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Tag Sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  glycolate

<400>  14

Ala Ala Pro Cys Xaa Phe Gly 
1               5           


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Tag Sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  glycolate

<400>  15

Lys Ala Ala Pro Cys Xaa Phe Gly 
1               5               


<210>  16
<211>  690
<212>  PRT
<213>  Cavia porcellus

<400>  16

Met Ala Glu Asp Leu Ile Leu Glu Arg Cys Asp Leu Gln Leu Glu Val 
1               5                   10                  15      


Asn Gly Arg Asp His Arg Thr Ala Asp Leu Cys Arg Glu Arg Leu Val 
            20                  25                  30          


Leu Arg Arg Gly Gln Pro Phe Trp Leu Thr Leu His Phe Glu Gly Arg 
        35                  40                  45              


Gly Tyr Glu Ala Gly Val Asp Thr Leu Thr Phe Asn Ala Val Thr Gly 
    50                  55                  60                  


Pro Asp Pro Ser Glu Glu Ala Gly Thr Met Ala Arg Phe Ser Leu Ser 
65                  70                  75                  80  


Ser Ala Val Glu Gly Gly Thr Trp Ser Ala Ser Ala Val Asp Gln Gln 
                85                  90                  95      


Asp Ser Thr Val Ser Leu Leu Leu Ser Thr Pro Ala Asp Ala Pro Ile 
            100                 105                 110         


Gly Leu Tyr Arg Leu Ser Leu Glu Ala Ser Thr Gly Tyr Gln Gly Ser 
        115                 120                 125             


Ser Phe Val Leu Gly His Phe Ile Leu Leu Tyr Asn Pro Arg Cys Pro 
    130                 135                 140                 


Ala Asp Ala Val Tyr Met Asp Ser Asp Gln Glu Arg Gln Glu Tyr Val 
145                 150                 155                 160 


Leu Thr Gln Gln Gly Phe Ile Tyr Gln Gly Ser Ala Lys Phe Ile Asn 
                165                 170                 175     


Gly Ile Pro Trp Asn Phe Gly Gln Phe Glu Asp Gly Ile Leu Asp Ile 
            180                 185                 190         


Cys Leu Met Leu Leu Asp Thr Asn Pro Lys Phe Leu Lys Asn Ala Gly 
        195                 200                 205             


Gln Asp Cys Ser Arg Arg Ser Arg Pro Val Tyr Val Gly Arg Val Val 
    210                 215                 220                 


Ser Ala Met Val Asn Cys Asn Asp Asp Gln Gly Val Leu Gln Gly Arg 
225                 230                 235                 240 


Trp Asp Asn Asn Tyr Ser Asp Gly Val Ser Pro Met Ser Trp Ile Gly 
                245                 250                 255     


Ser Val Asp Ile Leu Arg Arg Trp Lys Asp Tyr Gly Cys Gln Arg Val 
            260                 265                 270         


Lys Tyr Gly Gln Cys Trp Val Phe Ala Ala Val Ala Cys Thr Val Leu 
        275                 280                 285             


Arg Cys Leu Gly Ile Pro Thr Arg Val Val Thr Asn Phe Asn Ser Ala 
    290                 295                 300                 


His Asp Gln Asn Ser Asn Leu Leu Ile Glu Tyr Phe Arg Asn Glu Ser 
305                 310                 315                 320 


Gly Glu Ile Glu Gly Asn Lys Ser Glu Met Ile Trp Asn Phe His Cys 
                325                 330                 335     


Trp Val Glu Ser Trp Met Thr Arg Pro Asp Leu Glu Pro Gly Tyr Glu 
            340                 345                 350         


Gly Trp Gln Ala Leu Asp Pro Thr Pro Gln Glu Lys Ser Glu Gly Thr 
        355                 360                 365             


Tyr Cys Cys Gly Pro Val Pro Val Arg Ala Ile Lys Glu Gly His Leu 
    370                 375                 380                 


Asn Val Lys Tyr Asp Ala Pro Phe Val Phe Ala Glu Val Asn Ala Asp 
385                 390                 395                 400 


Val Val Asn Trp Ile Arg Gln Lys Asp Gly Ser Leu Arg Lys Ser Ile 
                405                 410                 415     


Asn His Leu Val Val Gly Leu Lys Ile Ser Thr Lys Ser Val Gly Arg 
            420                 425                 430         


Asp Glu Arg Glu Asp Ile Thr His Thr Tyr Lys Tyr Pro Glu Gly Ser 
        435                 440                 445             


Glu Glu Glu Arg Glu Ala Phe Val Arg Ala Asn His Leu Asn Lys Leu 
    450                 455                 460                 


Ala Thr Lys Glu Glu Ala Gln Glu Glu Thr Gly Val Ala Met Arg Ile 
465                 470                 475                 480 


Arg Val Gly Gln Asn Met Thr Met Gly Ser Asp Phe Asp Ile Phe Ala 
                485                 490                 495     


Tyr Ile Thr Asn Gly Thr Ala Glu Ser His Glu Cys Gln Leu Leu Leu 
            500                 505                 510         


Cys Ala Arg Ile Val Ser Tyr Asn Gly Val Leu Gly Pro Val Cys Ser 
        515                 520                 525             


Thr Asn Asp Leu Leu Asn Leu Thr Leu Asp Pro Phe Ser Glu Asn Ser 
    530                 535                 540                 


Ile Pro Leu His Ile Leu Tyr Glu Lys Tyr Gly Asp Tyr Leu Thr Glu 
545                 550                 555                 560 


Ser Asn Leu Ile Lys Val Arg Gly Leu Leu Ile Glu Pro Ala Ala Asn 
                565                 570                 575     


Ser Tyr Val Leu Ala Glu Arg Asp Ile Tyr Leu Glu Asn Pro Glu Ile 
            580                 585                 590         


Lys Ile Arg Val Leu Gly Glu Pro Lys Gln Asn Arg Lys Leu Ile Ala 
        595                 600                 605             


Glu Val Ser Leu Lys Asn Pro Leu Pro Val Pro Leu Leu Gly Cys Ile 
    610                 615                 620                 


Phe Thr Val Glu Gly Ala Gly Leu Thr Lys Asp Gln Lys Ser Val Glu 
625                 630                 635                 640 


Val Pro Asp Pro Val Glu Ala Gly Glu Gln Ala Lys Val Arg Val Asp 
                645                 650                 655     


Leu Leu Pro Thr Glu Val Gly Leu His Lys Leu Val Val Asn Phe Glu 
            660                 665                 670         


Cys Asp Lys Leu Lys Ala Val Lys Gly Tyr Arg Asn Val Ile Ile Gly 
        675                 680                 685             


Pro Ala 
    690 


<210>  17
<211>  690
<212>  PRT
<213>  Cavia cutleri

<400>  17

Met Ala Glu Asp Leu Ile Leu Glu Arg Cys Asp Leu Gln Leu Glu Val 
1               5                   10                  15      


Asn Gly Arg Asp His Arg Thr Ala Asp Leu Cys Arg Glu Arg Leu Val 
            20                  25                  30          


Leu Arg Arg Gly Gln Pro Phe Trp Leu Thr Leu His Phe Glu Gly Arg 
        35                  40                  45              


Gly Tyr Glu Ala Gly Val Asp Thr Leu Thr Phe Asn Ala Val Thr Gly 
    50                  55                  60                  


Pro Asp Pro Ser Glu Glu Ala Gly Thr Met Ala Arg Phe Ser Leu Ser 
65                  70                  75                  80  


Ser Ala Val Glu Gly Gly Thr Trp Ser Ala Ser Ala Val Asp Gln Gln 
                85                  90                  95      


Asp Ser Thr Val Ser Leu Leu Leu Ser Thr Pro Ala Asp Ala Pro Ile 
            100                 105                 110         


Gly Leu Tyr Arg Leu Ser Leu Glu Ala Ser Thr Gly Tyr Gln Gly Ser 
        115                 120                 125             


Ser Phe Val Leu Gly His Phe Ile Leu Leu Tyr Asn Pro Arg Cys Pro 
    130                 135                 140                 


Ala Asp Ala Val Tyr Met Asp Ser Asp Gln Glu Arg Gln Glu Tyr Val 
145                 150                 155                 160 


Leu Thr Gln Gln Gly Phe Ile Tyr Gln Gly Ser Ala Lys Phe Ile Asn 
                165                 170                 175     


Gly Ile Pro Trp Asn Phe Gly Gln Phe Glu Asp Gly Ile Leu Asp Ile 
            180                 185                 190         


Cys Leu Met Leu Leu Asp Thr Asn Pro Lys Phe Leu Lys Asn Ala Gly 
        195                 200                 205             


Gln Asp Cys Ser Arg Arg Ser Arg Pro Val Tyr Val Gly Arg Val Val 
    210                 215                 220                 


Ser Ala Met Val Asn Cys Asn Asp Asp Gln Gly Val Leu Gln Gly Arg 
225                 230                 235                 240 


Trp Asp Asn Asn Tyr Ser Asp Gly Val Ser Pro Met Ser Trp Ile Gly 
                245                 250                 255     


Ser Val Asp Ile Leu Arg Arg Trp Lys Asp Tyr Gly Cys Gln Arg Val 
            260                 265                 270         


Lys Tyr Gly Gln Cys Trp Val Phe Ala Ala Val Ala Cys Thr Val Leu 
        275                 280                 285             


Arg Cys Leu Gly Ile Pro Thr Arg Val Val Thr Asn Phe Asn Ser Ala 
    290                 295                 300                 


His Asp Gln Asn Ser Asn Leu Leu Ile Glu Tyr Phe Arg Asn Glu Ser 
305                 310                 315                 320 


Gly Glu Ile Glu Gly Asn Lys Ser Glu Met Ile Trp Asn Phe His Cys 
                325                 330                 335     


Trp Val Glu Ser Trp Met Thr Arg Pro Asp Leu Glu Pro Gly Tyr Glu 
            340                 345                 350         


Gly Trp Gln Ala Leu Asp Pro Thr Pro Gln Glu Lys Ser Glu Gly Thr 
        355                 360                 365             


Tyr Cys Cys Gly Pro Val Pro Val Arg Ala Ile Lys Glu Gly His Leu 
    370                 375                 380                 


Asn Val Lys Tyr Asp Ala Pro Phe Val Phe Ala Glu Val Asn Ala Asp 
385                 390                 395                 400 


Val Val Asn Trp Ile Arg Gln Lys Asp Gly Ser Leu Arg Lys Ser Ile 
                405                 410                 415     


Asn His Leu Val Val Gly Leu Lys Ile Ser Thr Lys Ser Val Gly Arg 
            420                 425                 430         


Asp Glu Arg Glu Asp Ile Thr His Thr Tyr Lys Tyr Pro Glu Gly Ser 
        435                 440                 445             


Glu Glu Glu Arg Glu Ala Phe Val Arg Ala Asn His Leu Asn Lys Leu 
    450                 455                 460                 


Ala Thr Lys Glu Glu Ala Gln Glu Glu Thr Gly Val Ala Met Arg Ile 
465                 470                 475                 480 


Arg Val Gly Gln Asn Met Thr Met Gly Ser Asp Phe Asp Ile Phe Ala 
                485                 490                 495     


Tyr Ile Thr Asn Gly Thr Ala Glu Ser His Glu Cys Gln Leu Leu Leu 
            500                 505                 510         


Cys Ala Arg Ile Val Ser Tyr Asn Gly Val Leu Gly Pro Val Cys Ser 
        515                 520                 525             


Thr Asn Asp Leu Leu Asn Leu Thr Leu Asp Pro Phe Ser Glu Asn Ser 
    530                 535                 540                 


Ile Pro Leu His Ile Leu Tyr Glu Lys Tyr Gly Asp Tyr Leu Thr Glu 
545                 550                 555                 560 


Ser Asn Leu Ile Lys Val Arg Gly Leu Leu Ile Glu Pro Ala Ala Asn 
                565                 570                 575     


Ser Tyr Val Leu Ala Glu Arg Asp Ile Tyr Leu Glu Asn Pro Glu Ile 
            580                 585                 590         


Lys Ile Arg Val Leu Gly Glu Pro Lys Gln Asn Arg Lys Leu Ile Ala 
        595                 600                 605             


Glu Val Ser Leu Lys Asn Pro Leu Pro Val Pro Leu Leu Gly Cys Ile 
    610                 615                 620                 


Phe Thr Val Glu Gly Ala Gly Leu Thr Lys Asp Gln Lys Ser Val Glu 
625                 630                 635                 640 


Val Pro Asp Pro Val Glu Ala Gly Glu Gln Ala Lys Val Arg Val Asp 
                645                 650                 655     


Leu Leu Pro Thr Glu Val Gly Leu His Lys Leu Val Val Asn Phe Glu 
            660                 665                 670         


Cys Asp Lys Leu Lys Ala Val Lys Gly Tyr Arg Asn Val Ile Ile Gly 
        675                 680                 685             


Pro Ala 
    690 


<210>  18
<211>  395
<212>  PRT
<213>  Streptomyces mobaraensis

<400>  18

Met His Arg Arg Ile His Ala Val Gly Gln Ala Arg Pro Pro Pro Thr 
1               5                   10                  15      


Met Ala Arg Gly Lys Glu Thr Lys Ser Tyr Ala Glu Thr Tyr Arg Leu 
            20                  25                  30          


Thr Ala Asp Asp Val Ala Asn Ile Asn Ala Leu Asn Glu Ser Ala Pro 
        35                  40                  45              


Ala Ala Ser Ser Ala Gly Pro Ser Phe Arg Ala Pro Asp Ser Asp Asp 
    50                  55                  60                  


Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met Pro Asp Pro Tyr 
65                  70                  75                  80  


Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn Asn Tyr Ile Arg 
                85                  90                  95      


Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg Lys Gln Gln Met 
            100                 105                 110         


Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys Val Gly Val Thr 
        115                 120                 125             


Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu Ala Phe Ala Ser 
    130                 135                 140                 


Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn Gly Arg Pro Arg 
145                 150                 155                 160 


Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val Ala Lys Glu Ser 
                165                 170                 175     


Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu Val Ala Ser Val 
            180                 185                 190         


Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser Ala Tyr Leu Asp 
        195                 200                 205             


Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala Leu Arg Asn Glu 
    210                 215                 220                 


Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn Thr Pro Ser Phe 
225                 230                 235                 240 


Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg Met Lys Ala Val 
                245                 250                 255     


Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg Ser Ser Ser Ala 
            260                 265                 270         


Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg Ser Ala Pro Gly 
        275                 280                 285             


Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile Pro Arg Ser Pro 
    290                 295                 300                 


Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr Gly Trp Phe Gly 
305                 310                 315                 320 


Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp Thr His Gly Asn 
                325                 330                 335     


His Tyr His Ala Pro Asn Gly Ser Leu Gly Cys His Ala Cys Leu Thr 
            340                 345                 350         


Arg Ala Ser Ser Ala Thr Gly Ser Glu Gly Tyr Ser Asp Phe Asp Arg 
        355                 360                 365             


Gly Glu Pro Tyr Val Val Ser Pro Ser Pro Ser Pro Arg Met Leu Glu 
    370                 375                 380                 


His Arg Pro Arg Gln Gly Lys Ala Gly Leu Ala 
385                 390                 395 


<210>  19
<211>  395
<212>  PRT
<213>  Streptomyces mobaraensis

<400>  19

Met His Arg Arg Ile His Ala Val Gly Gln Ala Arg Pro Pro Pro Thr 
1               5                   10                  15      


Met Ala Arg Gly Lys Glu Thr Lys Ser Tyr Ala Glu Thr Tyr Arg Leu 
            20                  25                  30          


Thr Ala Asp Asp Val Ala Asn Ile Asn Ala Leu Asn Glu Ser Ala Pro 
        35                  40                  45              


Ala Ala Ser Ser Ala Gly Pro Ser Phe Arg Ala Pro Asp Ser Asp Asp 
    50                  55                  60                  


Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met Pro Asp Pro Tyr 
65                  70                  75                  80  


Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn Asn Tyr Ile Arg 
                85                  90                  95      


Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg Lys Gln Gln Met 
            100                 105                 110         


Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys Val Gly Val Thr 
        115                 120                 125             


Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu Ala Phe Ala Ser 
    130                 135                 140                 


Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn Gly Arg Pro Arg 
145                 150                 155                 160 


Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val Ala Lys Glu Ser 
                165                 170                 175     


Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu Val Ala Ser Val 
            180                 185                 190         


Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser Ala Tyr Leu Asp 
        195                 200                 205             


Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala Leu Arg Asn Glu 
    210                 215                 220                 


Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn Thr Pro Ser Phe 
225                 230                 235                 240 


Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg Met Lys Ala Val 
                245                 250                 255     


Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg Ser Ser Ser Ala 
            260                 265                 270         


Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg Ser Ala Pro Gly 
        275                 280                 285             


Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile Pro Arg Ser Pro 
    290                 295                 300                 


Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr Gly Trp Phe Gly 
305                 310                 315                 320 


Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp Thr His Gly Asn 
                325                 330                 335     


His Tyr His Ala Pro Asn Gly Ser Leu Gly Cys His Ala Cys Leu Thr 
            340                 345                 350         


Arg Ala Ser Ser Ala Thr Gly Ser Glu Gly Tyr Ser Asp Phe Asp Arg 
        355                 360                 365             


Gly Glu Pro Tyr Val Val Ser Pro Ser Pro Ser Pro Arg Met Leu Glu 
    370                 375                 380                 


His Arg Pro Arg Gln Gly Lys Ala Gly Leu Ala 
385                 390                 395 


<210>  20
<211>  410
<212>  PRT
<213>  Streptomyces mobaraensis

<400>  20

Met Ser Gln Arg Gly Arg Thr Leu Val Phe Ala Ala Leu Gly Ala Val 
1               5                   10                  15      


Met Cys Thr Thr Ala Leu Met Pro Ser Ala Gly Ala Ala Thr Gly Ser 
            20                  25                  30          


Gly Ser Gly Ser Gly Thr Gly Glu Glu Lys Arg Ser Tyr Ala Glu Thr 
        35                  40                  45              


His Arg Leu Thr Ala Asp Asp Val Asp Asp Ile Asn Ala Leu Asn Glu 
    50                  55                  60                  


Ser Ala Pro Ala Ala Ser Ser Ala Gly Pro Ser Phe Arg Ala Pro Asp 
65                  70                  75                  80  


Ser Asp Glu Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met Pro 
                85                  90                  95      


Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Ile Val Asn Asn 
            100                 105                 110         


Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg Lys 
        115                 120                 125             


Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys Val 
    130                 135                 140                 


Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu Ala 
145                 150                 155                 160 


Phe Ala Phe Phe Asp Glu Asp Lys Tyr Lys Asn Glu Leu Lys Asn Gly 
                165                 170                 175     


Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val Ala 
            180                 185                 190         


Lys Asp Ser Phe Asp Glu Ala Lys Gly Phe Gln Arg Ala Arg Asp Val 
        195                 200                 205             


Ala Ser Val Met Asn Lys Ala Leu Glu Asn Ala His Asp Glu Gly Ala 
    210                 215                 220                 


Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala Leu 
225                 230                 235                 240 


Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn Thr 
                245                 250                 255     


Pro Ser Phe Lys Asp Arg Asn Gly Gly Asn His Asp Pro Ser Lys Met 
            260                 265                 270         


Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg Ser 
        275                 280                 285             


Gly Ser Ser Asp Lys Arg Lys Tyr Gly Asp Pro Glu Ala Phe Arg Pro 
    290                 295                 300                 


Asp Arg Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile Pro 
305                 310                 315                 320 


Arg Ser Pro Thr Ser Pro Gly Glu Ser Phe Val Asn Phe Asp Tyr Gly 
                325                 330                 335     


Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp Thr 
            340                 345                 350         


His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met His 
        355                 360                 365             


Val Tyr Glu Ser Lys Phe Arg Asn Trp Ser Asp Gly Tyr Ser Asp Phe 
    370                 375                 380                 


Asp Arg Gly Ala Tyr Val Val Thr Phe Val Pro Lys Ser Trp Asn Thr 
385                 390                 395                 400 


Ala Pro Asp Lys Val Thr Gln Gly Trp Pro 
                405                 410 


