
                                SEQUENCE LISTING

<110> Genentech, Inc.

<120> ANTI-UBIQUITINATION ANTIBODIES AND METHODS OF USE

<130> 14639-20523.40

<140> Not Yet Assigned
<141> Concurrently Herewith

<150> US 63/212,075
<151> 2021-06-17

<160> 60

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 1
Gln Ser Val Lys Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro
 1               5                  10                  15      
Leu Thr Leu Thr Cys Lys Val Ser Gly Phe Ser Leu Ser Ser Tyr Tyr
            20                  25                  30          
Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly
        35                  40                  45              
Ile Met Phe Pro Asn Gly Lys Ile Tyr Tyr Ala Thr Trp Ala Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ile
65                  70                  75                  80  
Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Gly Asp Asp
                85                  90                  95      
Ser Gly Asp Val Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser
    


<210> 2
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 2
Asp Ile Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Thr Asn
            20                  25                  30          
Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Ala Lys Glu
        35                  40                  45              
Met Ile Tyr Gly Ala Ser Thr Leu Pro Ser Gly Val Ser Ser Arg Phe
    50                  55                  60                  
Lys Gly Ser Gly Ser Gly Thr Gln Phe Ala Leu Thr Ile Ser Asp Val
65                  70                  75                  80  
Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Thr Tyr Asp Cys
                85                  90                  95      
Leu Ser Ala Asp Cys Leu Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile
            100                 105                 110         
Lys
    


<210> 3
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 3
Ser Tyr Tyr Met Asn
 1               5  


<210> 4
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 4
Ile Met Phe Pro Asn Gly Lys Ile Tyr Tyr Ala Thr Trp Ala
 1               5                  10                  


<210> 5
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 5
Asp Asp Ser Gly Asp Val Asn Ile
 1               5              


<210> 6
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 6
Gln Ser Ser Gln Ser Val Tyr Thr Asn Asn Arg Leu Ala
 1               5                  10              


<210> 7
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 7
Gly Ala Ser Thr Leu Pro Ser
 1               5          


<210> 8
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 8
Leu Gly Thr Tyr Asp Cys Leu Ser Ala Asp Cys Leu Ala
 1               5                  10              


<210> 9
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 9
Gln Ser Val Glu Glu Ser Gly Gly Gly Leu Val Thr Pro Gly Gly Ala
 1               5                  10                  15      
Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Asn Arg His Trp
            20                  25                  30          
Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly
        35                  40                  45              
Ala Ile Asn Glu Ser Gly Arg Thr Tyr Tyr Ala Thr Trp Ala Lys Gly
    50                  55                  60                  
Arg Phe Phe Ile Ser Lys Thr Thr Thr Thr Val Asp Leu Lys Ile Thr
65                  70                  75                  80  
Ser Pro Thr Thr Ala Asp Thr Ala Thr Tyr Phe Cys Val Arg Asp Asp
                85                  90                  95      
Asp Val Ser Asn Phe Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser
            100                 105                 110         


<210> 10
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 10
Asp Pro Met Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Ser Ile Asn Cys Gln Ser Thr Lys Ser Val Tyr Lys Tyr
            20                  25                  30          
Asn His Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln
        35                  40                  45              
Leu Ile Phe Pro Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe
    50                  55                  60                  
Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val
65                  70                  75                  80  
Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Leu Tyr Asp Cys
                85                  90                  95      
Arg Ser Gly Asp Cys Asn Val Phe Gly Gly Gly Thr Lys Leu Glu Ile
            100                 105                 110         
Lys
    


<210> 11
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 11
Arg His Trp Met Asn
 1               5  


<210> 12
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 12
Ala Ile Asn Glu Ser Gly Arg Thr Tyr Tyr Ala Thr Trp Ala
 1               5                  10                  


<210> 13
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 13
Asp Asp Asp Val Ser Asn Phe
 1               5          


<210> 14
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 14
Gln Ser Thr Lys Ser Val Tyr Lys Tyr Asn His Leu Ser
 1               5                  10              


<210> 15
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 15
Pro Ala Ser Thr Leu Gln Ser
 1               5          


<210> 16
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 16
Leu Gly Leu Tyr Asp Cys Arg Ser Gly Asp Cys Asn Val
 1               5                  10              


<210> 17
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 17
Gln Lys Gln Leu Met Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr
 1               5                  10                  15      
Pro Leu Thr Leu Thr Cys Lys Val Ser Gly Phe Ser Leu Ser Ser Tyr
            20                  25                  30          
Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ile Met Phe Pro Asn Gly Lys Ile Tyr Tyr Ala Thr Trp Ala Lys
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile
65                  70                  75                  80  
Ile Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Gly Asp
                85                  90                  95      
Asp Ser Gly Asp Val Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val
            100                 105                 110         
Ser Ser
        


<210> 18
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 18
Asp Ile Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Thr Asn
            20                  25                  30          
Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Ala Lys Glu
        35                  40                  45              
Met Ile Tyr Gly Ala Ser Thr Leu Pro Ser Gly Val Ser Ser Arg Phe
    50                  55                  60                  
Lys Gly Ser Gly Ser Gly Thr Gln Phe Ala Leu Thr Ile Ser Asp Val
65                  70                  75                  80  
Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Glu Phe Asp Cys
                85                  90                  95      
Thr Ser Ala Asp Cys Phe Val Phe Gly Gly Gly Thr Glu Val Val Val
            100                 105                 110         
Lys
    


<210> 19
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 19
Ser Tyr Tyr Met Asn
 1               5  


<210> 20
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 20
Ile Met Phe Pro Asn Gly Lys Ile Tyr Tyr Ala Thr Trp Ala
 1               5                  10                  


<210> 21
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 21
Asp Asp Ser Gly Asp Val Asn Ile
 1               5              


<210> 22
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 22
Gln Ser Ser Gln Ser Val Tyr Thr Asn Asn Arg Leu Ala
 1               5                  10              


<210> 23
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 23
Gly Ala Ser Thr Leu Pro Ser
 1               5          


<210> 24
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 24
Leu Gly Glu Phe Asp Cys Thr Ser Ala Asp Cys Phe Val
 1               5                  10              


<210> 25
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 25
Gln Ser Val Glu Glu Ser Arg Gly Arg Leu Val Thr Pro Gly Thr Pro
 1               5                  10                  15      
Leu Thr Leu Thr Cys Lys Val Ser Gly Phe Ser Leu Ser Ser Tyr Tyr
            20                  25                  30          
Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly
        35                  40                  45              
Ile Met Phe Pro Asn Gly Lys Ile Tyr Tyr Ala Thr Trp Ala Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ile
65                  70                  75                  80  
Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Gly Asp Asp
                85                  90                  95      
Ser Gly Asp Val Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser
    


<210> 26
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 26
Asp Pro Met Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Ser Asn
            20                  25                  30          
Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Glu
        35                  40                  45              
Met Ile Tyr Gly Ala Ser Thr Leu Pro Ser Gly Val Ser Ser Arg Phe
    50                  55                  60                  
Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val
65                  70                  75                  80  
Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Thr Tyr Asp Cys
                85                  90                  95      
Leu Ser Ala Asp Cys Leu Ala Phe Gly Gly Gly Thr Glu Val Val Val
            100                 105                 110         
Lys
    


<210> 27
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 27
Ser Tyr Tyr Met Asn
 1               5  


<210> 28
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 28
Ile Met Phe Pro Asn Gly Lys Ile Tyr Tyr Ala Thr Trp Ala
 1               5                  10                  


<210> 29
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 29
Asp Asp Ser Gly Asp Val Asn Ile
 1               5              


<210> 30
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 30
Gln Ser Ser Gln Ser Val Tyr Ser Asn Asn Arg Leu Ala
 1               5                  10              


<210> 31
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 31
Gly Ala Ser Thr Leu Pro Ser
 1               5          


<210> 32
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 32
Leu Gly Thr Tyr Asp Cys Leu Ser Ala Asp Cys Leu Ala
 1               5                  10              


<210> 33
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1, 2, 3, 4, 5, 8, 10, 16, 17, 23, 24, 30, 31, 32, 33, 50,
51, 52, 53, 54, 56, 57, 68, 73, 81, 86, 94, 95, 98, 99,
100, 101, 103
<223> Xaa = Any Amino Acid

<400> 33
Xaa Xaa Xaa Xaa Xaa Glu Ser Xaa Gly Xaa Leu Val Thr Pro Gly Xaa
 1               5                  10                  15      
Xaa Leu Thr Leu Thr Cys Xaa Xaa Ser Gly Phe Ser Leu Xaa Xaa Xaa
            20                  25                  30          
Xaa Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Tyr Tyr Ala Thr Trp Ala Lys
    50                  55                  60                  
Gly Arg Phe Xaa Ile Ser Lys Thr Xaa Thr Thr Val Asp Leu Lys Ile
65                  70                  75                  80  
Xaa Ser Pro Thr Thr Xaa Asp Thr Ala Thr Tyr Phe Cys Xaa Xaa Asp
                85                  90                  95      
Asp Xaa Xaa Xaa Xaa Asn Xaa Trp Gly Pro Gly Thr Leu Val Thr Val
            100                 105                 110         
Ser Ser
        


<210> 34
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 2, 3, 8, 10, 20, 26, 27, 31, 32, 34, 36, 46, 48, 49, 51,
52, 57, 61, 65, 74, 93, 94, 97, 99, 102, 103, 109, 110,
111, 112
<223> Xaa = Any Amino Acid

<400> 34
Asp Xaa Xaa Leu Thr Gln Thr Xaa Ser Xaa Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Xaa Ile Asn Cys Gln Ser Xaa Xaa Ser Val Tyr Xaa Xaa
            20                  25                  30          
Asn Xaa Leu Xaa Trp Tyr Gln Gln Lys Pro Gly Gln Pro Xaa Lys Xaa
        35                  40                  45              
Xaa Ile Xaa Xaa Ala Ser Thr Leu Xaa Ser Gly Val Xaa Ser Arg Phe
    50                  55                  60                  
Xaa Gly Ser Gly Ser Gly Thr Gln Phe Xaa Leu Thr Ile Ser Asp Val
65                  70                  75                  80  
Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Xaa Xaa Asp Cys
                85                  90                  95      
Xaa Ser Xaa Asp Cys Xaa Xaa Phe Gly Gly Gly Thr Xaa Xaa Xaa Xaa
            100                 105                 110         
Lys
    


<210> 35
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1, 2, 3
<223> Xaa = Any Amino Acid

<400> 35
Xaa Xaa Xaa Met Asn
 1               5  


<210> 36
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1, 2, 3, 4, 5, 7, 8
<223> Xaa = Any Amino Acid

<400> 36
Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Tyr Tyr Ala Thr Trp Ala
 1               5                  10                  


<210> 37
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 3, 4, 5, 6, 8
<223> Xaa = Any Amino Acid

<400> 37
Asp Asp Xaa Xaa Xaa Xaa Asn Xaa
 1               5              


<210> 38
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 3, 4, 8, 9, 11, 13
<223> Xaa = Any Amino Acid

<400> 38
Gln Ser Xaa Xaa Ser Val Tyr Xaa Xaa Asn Xaa Leu Xaa
 1               5                  10              


<210> 39
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1, 6
<223> Xaa = Any Amino Acid

<400> 39
Xaa Ala Ser Thr Leu Xaa Ser
 1               5          


<210> 40
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 3, 4, 7, 9, 12, 13
<223> Xaa = Any Amino Acid

<400> 40
Leu Gly Xaa Xaa Asp Cys Xaa Ser Xaa Asp Cys Xaa Xaa
 1               5                  10              


<210> 41
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 41
Leu Ile Phe Ala Gly Lys Gly Gly Gln Leu Glu Asp Gly Arg
 1               5                  10                  


<210> 42
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 42
Thr Leu Ser Asp Tyr Asn Ile Gln Lys Gly Gly Glu Ser Thr Leu His
 1               5                  10                  15      
Leu Val Leu Arg
            20  


<210> 43
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 43
Gly Gly Met Leu Thr Asn Ala Arg
 1               5              


<210> 44
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 44
Gly Gly Met Ala Leu Ala Leu Ala Val Thr Lys
 1               5                  10      


<210> 45
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 45
Gly Gly Leu Ala Thr Phe His Gly Pro Gly Gln Leu Leu Cys His Pro
 1               5                  10                  15      
Val Leu Asp Leu Arg
            20      


<210> 46
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 46
Gly Gly Met Thr Ser Thr Tyr Gly Arg
 1               5                  


<210> 47
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 47
Gly Gly Met Phe Gly Ser Ala Pro Gln Arg Pro Val Ala Met Thr Thr
 1               5                  10                  15      
Ala Gln Arg
            


<210> 48
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 48
Gly Gly Met Gln Leu Lys Pro Met Glu Ile Asn Pro Glu Met Leu Asn
 1               5                  10                  15      
Lys
    


<210> 49
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 49
Gly Gly Met Thr Gly Asn Ala Gly Glu Trp Cys Leu Met Glu Ser Asp
 1               5                  10                  15      
Pro Gly Val Phe Thr Glu Leu Ile Lys
            20                  25  


<210> 50
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 50
Gly Gly Met Gln Leu Lys Pro Met Glu
 1               5                  


<210> 51
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 51
Gly Gly Met Thr Gly Asn Ala Gly Glu Trp Cys Leu Met Glu
 1               5                  10                  


<210> 52
<211> 436
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 52
Gln Ser Val Lys Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro
 1               5                  10                  15      
Leu Thr Leu Thr Cys Lys Val Ser Gly Phe Ser Leu Ser Ser Tyr Tyr
            20                  25                  30          
Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly
        35                  40                  45              
Ile Met Phe Pro Asn Gly Lys Ile Tyr Tyr Ala Thr Trp Ala Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ile
65                  70                  75                  80  
Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Gly Asp Asp
                85                  90                  95      
Ser Gly Asp Val Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Cys
        115                 120                 125             
Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly
    130                 135                 140                 
Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr
145                 150                 155                 160 
Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr
                165                 170                 175     
Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr
            180                 185                 190         
Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val
        195                 200                 205             
Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu
    210                 215                 220                 
Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu
225                 230                 235                 240 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
                245                 250                 255     
Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln
            260                 265                 270         
Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr
        275                 280                 285             
Ile Arg Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg
    290                 295                 300                 
Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro
305                 310                 315                 320 
Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys
                325                 330                 335     
Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val
            340                 345                 350         
Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val
        355                 360                 365             
Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro
    370                 375                 380                 
Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser
385                 390                 395                 400 
Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val
                405                 410                 415     
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg
            420                 425                 430         
Ser Pro Gly Lys
        435     


<210> 53
<211> 217
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 53
Asp Ile Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Thr Asn
            20                  25                  30          
Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Ala Lys Glu
        35                  40                  45              
Met Ile Tyr Gly Ala Ser Thr Leu Pro Ser Gly Val Ser Ser Arg Phe
    50                  55                  60                  
Lys Gly Ser Gly Ser Gly Thr Gln Phe Ala Leu Thr Ile Ser Asp Val
65                  70                  75                  80  
Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Thr Tyr Asp Cys
                85                  90                  95      
Leu Ser Ala Asp Cys Leu Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile
            100                 105                 110         
Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala
        115                 120                 125             
Asp Gln Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys
    130                 135                 140                 
Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln
145                 150                 155                 160 
Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys
                165                 170                 175     
Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn
            180                 185                 190         
Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val
        195                 200                 205             
Val Gln Ser Phe Asn Arg Gly Asp Cys
    210                 215         


<210> 54
<211> 435
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 54
Gln Ser Val Glu Glu Ser Gly Gly Gly Leu Val Thr Pro Gly Gly Ala
 1               5                  10                  15      
Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Asn Arg His Trp
            20                  25                  30          
Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly
        35                  40                  45              
Ala Ile Asn Glu Ser Gly Arg Thr Tyr Tyr Ala Thr Trp Ala Lys Gly
    50                  55                  60                  
Arg Phe Phe Ile Ser Lys Thr Thr Thr Thr Val Asp Leu Lys Ile Thr
65                  70                  75                  80  
Ser Pro Thr Thr Ala Asp Thr Ala Thr Tyr Phe Cys Val Arg Asp Asp
                85                  90                  95      
Asp Val Ser Asn Phe Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser
            100                 105                 110         
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly
        115                 120                 125             
Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr
    130                 135                 140                 
Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn
145                 150                 155                 160 
Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser
                165                 170                 175     
Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys
            180                 185                 190         
Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala
        195                 200                 205             
Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly
    210                 215                 220                 
Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
225                 230                 235                 240 
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln
                245                 250                 255     
Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val
            260                 265                 270         
Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile
        275                 280                 285             
Arg Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly
    290                 295                 300                 
Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile
305                 310                 315                 320 
Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val
                325                 330                 335     
Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser
            340                 345                 350         
Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu
        355                 360                 365             
Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala
    370                 375                 380                 
Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val
385                 390                 395                 400 
Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met
                405                 410                 415     
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser
            420                 425                 430         
Pro Gly Lys
        435 


<210> 55
<211> 217
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 55
Asp Pro Met Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Ser Ile Asn Cys Gln Ser Thr Lys Ser Val Tyr Lys Tyr
            20                  25                  30          
Asn His Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln
        35                  40                  45              
Leu Ile Phe Pro Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe
    50                  55                  60                  
Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val
65                  70                  75                  80  
Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Leu Tyr Asp Cys
                85                  90                  95      
Arg Ser Gly Asp Cys Asn Val Phe Gly Gly Gly Thr Lys Leu Glu Ile
            100                 105                 110         
Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala
        115                 120                 125             
Asp Gln Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys
    130                 135                 140                 
Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln
145                 150                 155                 160 
Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys
                165                 170                 175     
Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn
            180                 185                 190         
Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val
        195                 200                 205             
Val Gln Ser Phe Asn Arg Gly Asp Cys
    210                 215         


<210> 56
<211> 437
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 56
Gln Lys Gln Leu Met Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr
 1               5                  10                  15      
Pro Leu Thr Leu Thr Cys Lys Val Ser Gly Phe Ser Leu Ser Ser Tyr
            20                  25                  30          
Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ile Met Phe Pro Asn Gly Lys Ile Tyr Tyr Ala Thr Trp Ala Lys
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile
65                  70                  75                  80  
Ile Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Gly Asp
                85                  90                  95      
Asp Ser Gly Asp Val Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val
            100                 105                 110         
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys
        115                 120                 125             
Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys
    130                 135                 140                 
Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu
145                 150                 155                 160 
Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu
                165                 170                 175     
Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val
            180                 185                 190         
Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr
        195                 200                 205             
Val Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu
    210                 215                 220                 
Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr
225                 230                 235                 240 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
                245                 250                 255     
Ser Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu
            260                 265                 270         
Gln Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser
        275                 280                 285             
Thr Ile Arg Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu
    290                 295                 300                 
Arg Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala
305                 310                 315                 320 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro
                325                 330                 335     
Lys Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser
            340                 345                 350         
Val Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser
        355                 360                 365             
Val Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr
    370                 375                 380                 
Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu
385                 390                 395                 400 
Ser Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser
                405                 410                 415     
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser
            420                 425                 430         
Arg Ser Pro Gly Lys
        435         


<210> 57
<211> 217
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 57
Asp Ile Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Thr Asn
            20                  25                  30          
Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Ala Lys Glu
        35                  40                  45              
Met Ile Tyr Gly Ala Ser Thr Leu Pro Ser Gly Val Ser Ser Arg Phe
    50                  55                  60                  
Lys Gly Ser Gly Ser Gly Thr Gln Phe Ala Leu Thr Ile Ser Asp Val
65                  70                  75                  80  
Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Glu Phe Asp Cys
                85                  90                  95      
Thr Ser Ala Asp Cys Phe Val Phe Gly Gly Gly Thr Glu Val Val Val
            100                 105                 110         
Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala
        115                 120                 125             
Asp Gln Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys
    130                 135                 140                 
Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln
145                 150                 155                 160 
Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys
                165                 170                 175     
Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn
            180                 185                 190         
Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val
        195                 200                 205             
Val Gln Ser Phe Asn Arg Gly Asp Cys
    210                 215         


<210> 58
<211> 436
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 58
Gln Ser Val Glu Glu Ser Arg Gly Arg Leu Val Thr Pro Gly Thr Pro
 1               5                  10                  15      
Leu Thr Leu Thr Cys Lys Val Ser Gly Phe Ser Leu Ser Ser Tyr Tyr
            20                  25                  30          
Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly
        35                  40                  45              
Ile Met Phe Pro Asn Gly Lys Ile Tyr Tyr Ala Thr Trp Ala Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ile
65                  70                  75                  80  
Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Gly Asp Asp
                85                  90                  95      
Ser Gly Asp Val Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Cys
        115                 120                 125             
Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly
    130                 135                 140                 
Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr
145                 150                 155                 160 
Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr
                165                 170                 175     
Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr
            180                 185                 190         
Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val
        195                 200                 205             
Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu
    210                 215                 220                 
Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu
225                 230                 235                 240 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
                245                 250                 255     
Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln
            260                 265                 270         
Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr
        275                 280                 285             
Ile Arg Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg
    290                 295                 300                 
Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro
305                 310                 315                 320 
Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys
                325                 330                 335     
Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val
            340                 345                 350         
Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val
        355                 360                 365             
Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro
    370                 375                 380                 
Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser
385                 390                 395                 400 
Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val
                405                 410                 415     
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg
            420                 425                 430         
Ser Pro Gly Lys
        435     


<210> 59
<211> 217
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 59
Asp Pro Met Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Ser Asn
            20                  25                  30          
Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Glu
        35                  40                  45              
Met Ile Tyr Gly Ala Ser Thr Leu Pro Ser Gly Val Ser Ser Arg Phe
    50                  55                  60                  
Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val
65                  70                  75                  80  
Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Thr Tyr Asp Cys
                85                  90                  95      
Leu Ser Ala Asp Cys Leu Ala Phe Gly Gly Gly Thr Glu Val Val Val
            100                 105                 110         
Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala
        115                 120                 125             
Asp Gln Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys
    130                 135                 140                 
Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln
145                 150                 155                 160 
Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys
                165                 170                 175     
Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn
            180                 185                 190         
Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val
        195                 200                 205             
Val Gln Ser Phe Asn Arg Gly Asp Cys
    210                 215         


<210> 60
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = R or K

<220> 
<221> VARIANT        
<222> 4, 5, 6, 7
<223> Xaa = Any Amino Acid

<400> 60
Xaa Gly Gly Xaa Xaa Xaa Xaa
 1               5          

