                         SEQUENCE LISTING

<110>  Innovative Cellular Therapeutics, Inc
       Innovative Cellular Therapeutics Holdings Limited
 
<120>  Modified Cell Targeting Tumor ECM and Therapy thereof

<130>  I071-0096PCT

<150>  63/212,303
<151>  2021-06-18

<150>  63/218,020
<151>  2021-07-02

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  1

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Gly Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Lys Thr Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Asn Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Ala Val Phe Gly Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn His Arg 
                165                 170                 175     


Gly Asn Thr Asn Asp Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser 
            180                 185                 190         


Val Asp Thr Ser Lys Asn Gln Phe Ala Leu Lys Leu Ser Ser Val Thr 
        195                 200                 205             


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Arg Gly Tyr Thr 
    210                 215                 220                 


Tyr Gly Asn Phe Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser 
    


<210>  2
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  2

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  3
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  3

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  4
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  5
<211>  113
<212>  DNA
<213>  Homo sapiens

<400>  5
cattttgaca cccccataat atttttccag aattaacagt ataaattgca tctcttgttc       60

aagagttccc tatcactctc tttaatcact actcacagta acctcaactc ctg             113


<210>  6
<211>  277
<212>  DNA
<213>  Homo sapiens

<400>  6
tcgaggtcga cggtatcgat aagcttgata tcgaattagg aggaaaaact gtttcataca       60

gaaggcgtca attaggagga aaaactgttt catacagaag gcgtcaatta ggaggaaaaa      120

ctgtttcata cagaaggcgt caattggtcc catcgaatta ggaggaaaaa ctgtttcata      180

cagaaggcgt caattaggag gaaaaactgt ttcatacaga aggcgtcaat taggaggaaa      240

aactgtttca tacagaaggc gtcaattggt cccggga                               277


<210>  7
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Trp Gly Leu Lys Val Leu Leu Leu Pro Val Val Ser Phe Ala Arg 
1               5                   10                  15      


Ala Pro Asp Ser Val Asp Tyr Arg Lys Lys Gly Tyr Val Thr Pro Val 
            20                  25                  30          


Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ser Val Gly 
        35                  40                  45              


Ala Leu Glu Gly Gln Leu Lys Lys Lys Thr Gly Lys Leu Leu Asn Leu 
    50                  55                  60                  


Ser Pro Gln Asn Leu Val Asp Cys Val Ser Glu Asn Asp Gly Cys Gly 
65                  70                  75                  80  


Gly Gly Tyr Met Thr Asn Ala Phe Gln Tyr Val Gln Lys Asn Arg Gly 
                85                  90                  95      


Ile Asp Ser Glu Asp Ala Tyr Pro Tyr Val Gly Gln Glu Glu Ser Cys 
            100                 105                 110         


Met Tyr Asn Pro Thr Gly Lys Ala Ala Lys Cys Arg Gly Tyr Arg Glu 
        115                 120                 125             


Ile Pro Glu Gly Asn Glu Lys Ala Leu Lys Arg Ala Val Ala Arg Val 
    130                 135                 140                 


Gly Pro Val Ser Val Ala Ile Asp Ala Ser Leu Thr Ser Phe Gln Phe 
145                 150                 155                 160 


Tyr Ser Lys Gly Val Tyr Tyr Asp Glu Ser Cys Asn Ser Asp Asn Leu 
                165                 170                 175     


Asn His Ala Val Leu Ala Val Gly Tyr Gly Ile Gln Lys Gly Asn Lys 
            180                 185                 190         


His Trp Ile Ile Lys Asn Ser Trp Gly Glu Asn Trp Gly Asn Lys Gly 
        195                 200                 205             


Tyr Ile Leu Met Ala Arg Asn Lys Asn Asn Ala Cys Gly Ile Ala Asn 
    210                 215                 220                 


Leu Ala Ser Phe Pro Lys Met 
225                 230     


<210>  8
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  9
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  9
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60


<210>  10
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  10

Ile Val Gly Gly Arg Arg Ala Arg Pro His Ala Trp Pro Phe Met Val 
1               5                   10                  15      


Ser Leu Gln Leu Arg Gly Gly His Phe Cys Gly Ala Thr Leu Ile Ala 
            20                  25                  30          


Pro Asn Phe Val Met Ser Ala Ala His Cys Val Ala Asn Val Asn Val 
        35                  40                  45              


Arg Ala Val Arg Val Val Leu Gly Ala His Asn Leu Ser Arg Arg Glu 
    50                  55                  60                  


Pro Thr Arg Gln Val Phe Ala Val Gln Arg Ile Phe Glu Asn Gly Tyr 
65                  70                  75                  80  


Asp Pro Val Asn Leu Leu Asn Asp Ile Val Ile Leu Gln Leu Asn Gly 
                85                  90                  95      


Ser Ala Thr Ile Asn Ala Asn Val Gln Val Ala Gln Leu Pro Ala Gln 
            100                 105                 110         


Gly Arg Arg Leu Gly Asn Gly Val Gln Cys Leu Ala Met Gly Trp Gly 
        115                 120                 125             


Leu Leu Gly Arg Asn Arg Gly Ile Ala Ser Val Leu Gln Glu Leu Asn 
    130                 135                 140                 


Val Thr Val Val Thr Ser Leu Cys Arg Arg Ser Asn Val Cys Thr Leu 
145                 150                 155                 160 


Val Arg Gly Arg Gln Ala Gly Val Cys Phe Gly Asp Ser Gly Ser Pro 
                165                 170                 175     


Leu Val Cys Asn Gly Leu Ile His Gly Ile Ala Ser Phe Val Arg Gly 
            180                 185                 190         


Gly Cys Ala Ser Gly Leu Tyr Pro Asp Ala Phe Ala Pro Val Ala Gln 
        195                 200                 205             


Phe Val Asn Trp Ile Asp Ser Ile Ile Gln 
    210                 215             


<210>  11
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  11
atcgtgggcg gcaggagggc caggccccac gcctggccct tcatggtgag cctgcagctg       60

aggggcggcc acttctgcgg cgccaccctg atcgccccca acttcgtgat gagcgccgcc      120

cactgcgtgg ccaacgtgaa cgtgagggcc gtgagggtgg tgctgggcgc ccacaacctg      180

agcaggaggg agcccaccag gcaggtgttc gccgtgcaga ggatcttcga gaacggctac      240

gaccccgtga acctgctgaa cgacatcgtg atcctgcagc tgaacggcag cgccaccatc      300

aacgccaacg tgcaggtggc ccagctgccc gcccagggca ggaggctggg caacggcgtg      360

cagtgcctgg ccatgggctg gggcctgctg ggcaggaaca ggggcatcgc cagcgtgctg      420

caggagctga acgtgaccgt ggtgaccagc ctgtgcagga ggagcaacgt gtgcaccctg      480

gtgaggggca ggcaggccgg cgtgtgcttc ggcgacagcg gcagccccct ggtgtgcaac      540

ggcctgatcc acggcatcgc cagcttcgtg aggggcggct gcgccagcgg cctgtacccc      600

gacgccttcg cccccgtggc ccagttcgtg aactggatcg acagcatcat ccagatgtac      660

aggatgcaac tcctgtcttg cattgcacta agtcttgcac ttgtcacgaa ttcg            714


<210>  12
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  12
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

atcgtgggcg gcaggagggc caggccccac gcctggccct tcatggtgag cctgcagctg      120

aggggcggcc acttctgcgg cgccaccctg atcgccccca acttcgtgat gagcgccgcc      180

cactgcgtgg ccaacgtgaa cgtgagggcc gtgagggtgg tgctgggcgc ccacaacctg      240

agcaggaggg agcccaccag gcaggtgttc gccgtgcaga ggatcttcga gaacggctac      300

gaccccgtga acctgctgaa cgacatcgtg atcctgcagc tgaacggcag cgccaccatc      360

aacgccaacg tgcaggtggc ccagctgccc gcccagggca ggaggctggg caacggcgtg      420

cagtgcctgg ccatgggctg gggcctgctg ggcaggaaca ggggcatcgc cagcgtgctg      480

caggagctga acgtgaccgt ggtgaccagc ctgtgcagga ggagcaacgt gtgcaccctg      540

gtgaggggca ggcaggccgg cgtgtgcttc ggcgacagcg gcagccccct ggtgtgcaac      600

ggcctgatcc acggcatcgc cagcttcgtg aggggcggct gcgccagcgg cctgtacccc      660

gacgccttcg cccccgtggc ccagttcgtg aactggatcg acagcatcat ccag            714


<210>  13
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  13

Met His Pro Gly Val Leu Ala Ala Phe Leu Phe Leu Ser Trp Thr His 
1               5                   10                  15      


Cys Arg Ala Tyr Asn Val Phe Pro Arg Thr Leu Lys Trp Ser Lys Met 
            20                  25                  30          


Asn Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp Met Thr His Ser 
        35                  40                  45              


Glu Val Glu Lys Ala Phe Lys Lys Ala Phe Lys Val Trp Ser Asp Val 
    50                  55                  60                  


Thr Pro Leu Asn Phe Thr Arg Leu His Asp Gly Ile Ala Asp Ile Met 
65                  70                  75                  80  


Ile Ser Phe Gly Ile Lys Glu His Gly Asp Phe Tyr Pro Phe Asp Gly 
                85                  90                  95      


Pro Ser Gly Leu Leu Ala His Ala Phe Pro Pro Gly Pro Asn Tyr Gly 
            100                 105                 110         


Gly Asp Ala His Phe Asp Asp Asp Glu Thr Trp Thr Ser Ser Ser Lys 
        115                 120                 125             


Gly Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ser Leu 
    130                 135                 140                 


Gly Leu Asp His Ser Lys Asp Pro Gly Ala Leu Met Phe Pro Ile Tyr 
145                 150                 155                 160 


Thr Tyr Thr Gly Lys Ser His Phe Met Leu Pro Asp Asp Asp Val Gln 
                165                 170                 175     


Gly Ile Gln Ser Leu Tyr Gly Pro Gly Asp Glu Asp Pro Asn Pro Lys 
            180                 185                 190         


His Pro Lys Thr Pro Asp Lys Cys Asp Pro Ser Leu Ser Leu Asp Ala 
        195                 200                 205             


Ile Thr Ser Leu Arg Gly Glu Thr Met Ile Phe Lys Asp Arg Phe Phe 
    210                 215                 220                 


Trp Arg Leu His Pro Gln Gln Val Asp Ala Glu Leu Phe Leu Thr Lys 
225                 230                 235                 240 


Ser Phe Trp Pro Glu Leu Pro Asn Arg Ile Asp Ala Ala Tyr Glu His 
                245                 250                 255     


Pro Ser His Asp Leu Ile Phe Ile Phe Arg Gly Arg Lys Phe Trp Ala 
            260                 265                 270         


Leu Asn Gly Tyr Asp Ile Leu Glu Gly Tyr Pro Lys Lys Ile Ser Glu 
        275                 280                 285             


Leu Gly Leu Pro Lys Glu Val Lys Lys Ile Ser Ala Ala Val His Phe 
    290                 295                 300                 


Glu Asp Thr Gly Lys Thr Leu Leu Phe Ser Gly Asn Gln Val Trp Arg 
305                 310                 315                 320 


Tyr Asp Asp Thr Asn His Ile Met Asp Lys Asp Tyr Pro Arg Leu Ile 
                325                 330                 335     


Glu Glu Asp Phe Pro Gly Ile Gly Asp Lys Val Asp Ala Val Tyr Glu 
            340                 345                 350         


Lys Asn Gly Tyr Ile Tyr Phe Phe Asn Gly Pro Ile Gln Phe Glu Tyr 
        355                 360                 365             


Ser Ile Trp Ser Asn Arg Ile Val Arg Val Met Pro Ala Asn Ser Ile 
    370                 375                 380                 


Leu Trp Cys 
385         


<210>  14
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Glu Ala Leu Met Ala Arg Gly Ala Leu Thr Gly Pro Leu Arg Ala 
1               5                   10                  15      


Leu Cys Leu Leu Gly Cys Leu Leu Ser His Ala Ala Ala Tyr Asn Phe 
            20                  25                  30          


Phe Pro Arg Lys Pro Lys Trp Asp Lys Asn Gln Ile Thr Tyr Arg Ile 
        35                  40                  45              


Ile Gly Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val Asp Asp Ala Phe 
    50                  55                  60                  


Ala Arg Ala Phe Gln Val Trp Ser Asp Val Thr Pro Leu Arg Phe Ser 
65                  70                  75                  80  


Arg Ile His Asp Gly Glu Ala Asp Ile Met Ile Asn Phe Gly Arg Trp 
                85                  90                  95      


Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala 
            100                 105                 110         


His Ala Phe Ala Pro Gly Thr Gly Val Gly Gly Asp Ser His Phe Asp 
        115                 120                 125             


Asp Asp Glu Leu Trp Thr Leu Gly Glu Gly Gln Val Val Arg Val Lys 
    130                 135                 140                 


Tyr Gly Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro Phe Leu Phe Asn 
145                 150                 155                 160 


Gly Lys Glu Tyr Asn Ser Cys Thr Asp Thr Gly Arg Ser Asp Gly Phe 
                165                 170                 175     


Leu Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp Gly Lys Tyr Gly 
            180                 185                 190         


Phe Cys Pro His Glu Ala Leu Phe Thr Met Gly Gly Asn Ala Glu Gly 
        195                 200                 205             


Gln Pro Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr Ser Tyr Asp Ser 
    210                 215                 220                 


Cys Thr Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp Cys Gly Thr Thr 
225                 230                 235                 240 


Glu Asp Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys Pro Glu Thr Ala 
                245                 250                 255     


Met Ser Thr Val Gly Gly Asn Ser Glu Gly Ala Pro Cys Val Phe Pro 
            260                 265                 270         


Phe Thr Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr Ser Ala Gly Arg 
        275                 280                 285             


Ser Asp Gly Lys Met Trp Cys Ala Thr Thr Ala Asn Tyr Asp Asp Asp 
    290                 295                 300                 


Arg Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val 
305                 310                 315                 320 


Ala Ala His Glu Phe Gly His Ala Met Gly Leu Glu His Ser Gln Asp 
                325                 330                 335     


Pro Gly Ala Leu Met Ala Pro Ile Tyr Thr Tyr Thr Lys Asn Phe Arg 
            340                 345                 350         


Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Glu Leu Tyr Gly Ala Ser 
        355                 360                 365             


Pro Asp Ile Asp Leu Gly Thr Gly Pro Thr Pro Thr Leu Gly Pro Val 
    370                 375                 380                 


Thr Pro Glu Ile Cys Lys Gln Asp Ile Val Phe Asp Gly Ile Ala Gln 
385                 390                 395                 400 


Ile Arg Gly Glu Ile Phe Phe Phe Lys Asp Arg Phe Ile Trp Arg Thr 
                405                 410                 415     


Val Thr Pro Arg Asp Lys Pro Met Gly Pro Leu Leu Val Ala Thr Phe 
            420                 425                 430         


Trp Pro Glu Leu Pro Glu Lys Ile Asp Ala Val Tyr Glu Ala Pro Gln 
        435                 440                 445             


Glu Glu Lys Ala Val Phe Phe Ala Gly Asn Glu Tyr Trp Ile Tyr Ser 
    450                 455                 460                 


Ala Ser Thr Leu Glu Arg Gly Tyr Pro Lys Pro Leu Thr Ser Leu Gly 
465                 470                 475                 480 


Leu Pro Pro Asp Val Gln Arg Val Asp Ala Ala Phe Asn Trp Ser Lys 
                485                 490                 495     


Asn Lys Lys Thr Tyr Ile Phe Ala Gly Asp Lys Phe Trp Arg Tyr Asn 
            500                 505                 510         


Glu Val Lys Lys Lys Met Asp Pro Gly Phe Pro Lys Leu Ile Ala Asp 
        515                 520                 525             


Ala Trp Asn Ala Ile Pro Asp Asn Leu Asp Ala Val Val Asp Leu Gln 
    530                 535                 540                 


Gly Gly Gly His Ser Tyr Phe Phe Lys Gly Ala Tyr Tyr Leu Lys Leu 
545                 550                 555                 560 


Glu Asn Gln Ser Leu Lys Ser Val Lys Phe Gly Ser Ile Lys Ser Asp 
                565                 570                 575     


Trp Leu Gly Cys 
            580 


<210>  15
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Leu Trp Gln Pro Leu Val Leu Val Leu Leu Val Leu Gly Cys 
1               5                   10                  15      


Cys Phe Ala Phe Gln Thr Phe Glu Gly Asp Leu Lys Trp His His His 
            20                  25                  30          


Asn Ile Thr Tyr Trp Ile Gln Asn Tyr Ser Glu Asp Leu Pro Arg Ala 
        35                  40                  45              


Val Ile Asp Asp Ala Phe Ala Arg Ala Phe Ala Leu Trp Ser Ala Val 
    50                  55                  60                  


Thr Pro Leu Thr Phe Thr Arg Val Tyr Ser Arg Asp Ala Asp Ile Val 
65                  70                  75                  80  


Ile Gln Phe Gly Val Ala Glu His Gly Asp Gly Tyr Pro Phe Asp Gly 
                85                  90                  95      


Lys Asp Gly Leu Leu Ala His Ala Phe Pro Pro Gly Pro Gly Ile Gln 
            100                 105                 110         


Gly Asp Ala His Phe Asp Asp Asp Glu Leu Trp Ser Leu Gly Lys Gly 
        115                 120                 125             


Val Val Val Pro Thr Arg Phe Gly Asn Ala Asp Gly Ala Ala Cys His 
    130                 135                 140                 


Phe Pro Phe Ile Phe Glu Gly Arg Ser Tyr Ser Ala Cys Thr Thr Asp 
145                 150                 155                 160 


Gly Arg Ser Asp Gly Leu Pro Trp Cys Ser Thr Thr Ala Asn Tyr Asp 
                165                 170                 175     


Thr Asp Asp Arg Phe Gly Phe Cys Pro Ser Glu Arg Leu Tyr Thr Gln 
            180                 185                 190         


Asp Gly Asn Ala Asp Gly Lys Pro Cys Gln Phe Pro Phe Ile Phe Gln 
        195                 200                 205             


Gly Gln Ser Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Tyr 
    210                 215                 220                 


Arg Trp Cys Ala Thr Thr Ala Asn Tyr Asp Arg Asp Lys Leu Phe Gly 
225                 230                 235                 240 


Phe Cys Pro Thr Arg Ala Asp Ser Thr Val Met Gly Gly Asn Ser Ala 
                245                 250                 255     


Gly Glu Leu Cys Val Phe Pro Phe Thr Phe Leu Gly Lys Glu Tyr Ser 
            260                 265                 270         


Thr Cys Thr Ser Glu Gly Arg Gly Asp Gly Arg Leu Trp Cys Ala Thr 
        275                 280                 285             


Thr Ser Asn Phe Asp Ser Asp Lys Lys Trp Gly Phe Cys Pro Asp Gln 
    290                 295                 300                 


Gly Tyr Ser Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ala Leu 
305                 310                 315                 320 


Gly Leu Asp His Ser Ser Val Pro Glu Ala Leu Met Tyr Pro Met Tyr 
                325                 330                 335     


Arg Phe Thr Glu Gly Pro Pro Leu His Lys Asp Asp Val Asn Gly Ile 
            340                 345                 350         


Arg His Leu Tyr Gly Pro Arg Pro Glu Pro Glu Pro Arg Pro Pro Thr 
        355                 360                 365             


Thr Thr Thr Pro Gln Pro Thr Ala Pro Pro Thr Val Cys Pro Thr Gly 
    370                 375                 380                 


Pro Pro Thr Val His Pro Ser Glu Arg Pro Thr Ala Gly Pro Thr Gly 
385                 390                 395                 400 


Pro Pro Ser Ala Gly Pro Thr Gly Pro Pro Thr Ala Gly Pro Ser Thr 
                405                 410                 415     


Ala Thr Thr Val Pro Leu Ser Pro Val Asp Asp Ala Cys Asn Val Asn 
            420                 425                 430         


Ile Phe Asp Ala Ile Ala Glu Ile Gly Asn Gln Leu Tyr Leu Phe Lys 
        435                 440                 445             


Asp Gly Lys Tyr Trp Arg Phe Ser Glu Gly Arg Gly Ser Arg Pro Gln 
    450                 455                 460                 


Gly Pro Phe Leu Ile Ala Asp Lys Trp Pro Ala Leu Pro Arg Lys Leu 
465                 470                 475                 480 


Asp Ser Val Phe Glu Glu Arg Leu Ser Lys Lys Leu Phe Phe Phe Ser 
                485                 490                 495     


Gly Arg Gln Val Trp Val Tyr Thr Gly Ala Ser Val Leu Gly Pro Arg 
            500                 505                 510         


Arg Leu Asp Lys Leu Gly Leu Gly Ala Asp Val Ala Gln Val Thr Gly 
        515                 520                 525             


Ala Leu Arg Ser Gly Arg Gly Lys Met Leu Leu Phe Ser Gly Arg Arg 
    530                 535                 540                 


Leu Trp Arg Phe Asp Val Lys Ala Gln Met Val Asp Pro Arg Ser Ala 
545                 550                 555                 560 


Ser Glu Val Asp Arg Met Phe Pro Gly Val Pro Leu Asp Thr His Asp 
                565                 570                 575     


Val Phe Gln Tyr Arg Glu Lys Ala Tyr Phe Cys Gln Asp Arg Phe Tyr 
            580                 585                 590         


Trp Arg Val Ser Ser Arg Ser Glu Leu Asn Gln Val Asp Gln Val Gly 
        595                 600                 605             


Tyr Val Thr Tyr Asp Ile Leu Gln Cys Pro Glu Asp 
    610                 615                 620 


<210>  16
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Arg Leu Thr Val Leu Cys Ala Val Cys Leu Leu Pro Gly Ser Leu 
1               5                   10                  15      


Ala Tyr Ser Leu Phe Pro Asn Ser Pro Lys Trp Thr Ser Lys Val Val 
            20                  25                  30          


Thr Tyr Arg Ile Val Ser Tyr Thr Arg Asp Leu Pro His Ile Thr Val 
        35                  40                  45              


Asp Arg Leu Val Ser Lys Ala Leu Asn Met Trp Gly Lys Glu Ile Pro 
    50                  55                  60                  


Leu His Phe Arg Lys Val Val Trp Gly Thr Ala Asp Ile Met Ile Gly 
65                  70                  75                  80  


Phe Ala Arg Gly Ala His Gly Asp Ser Tyr Pro Phe Asp Gly Pro Gly 
                85                  90                  95      


Asn Thr Leu Ala His Ala Phe Ala Pro Gly Thr Gly Leu Gly Gly Asp 
            100                 105                 110         


Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asp Gly Ser Ser Leu Gly 
        115                 120                 125             


Ile Asn Phe Leu Tyr Ala Ala Thr His Glu Leu Gly His Ser Leu Gly 
    130                 135                 140                 


Met Gly His Ser Ser Asp Pro Asn Ala Val Met Tyr Pro Thr Tyr Gly 
145                 150                 155                 160 


Asn Gly Asp Pro Gln Asn Phe Lys Leu Ser Gln Asp Asp Ile Lys Gly 
                165                 170                 175     


Ile Gln Lys Leu Tyr Gly Lys Arg Ser Asn Ser Arg Lys Lys 
            180                 185                 190 


<210>  17
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Phe Ser Leu Lys Thr Leu Pro Phe Leu Leu Leu Leu His Val Gln 
1               5                   10                  15      


Ile Ser Lys Ala Leu Thr Pro Gly Asn Pro Lys Trp Glu Arg Thr Asn 
            20                  25                  30          


Leu Thr Tyr Arg Ile Arg Asn Tyr Thr Pro Gln Leu Ser Glu Ala Glu 
        35                  40                  45              


Val Glu Arg Ala Ile Lys Asp Ala Phe Glu Leu Trp Ser Val Ala Ser 
    50                  55                  60                  


Pro Leu Ile Phe Thr Arg Ile Ser Gln Gly Glu Ala Asp Ile Asn Ile 
65                  70                  75                  80  


Ala Phe Tyr Gln Arg Asp His Gly Asp Asn Ser Pro Phe Asp Gly Pro 
                85                  90                  95      


Asn Gly Ile Leu Ala His Ala Phe Gln Pro Gly Gln Gly Ile Gly Gly 
            100                 105                 110         


Asp Ala His Phe Asp Ala Glu Glu Thr Trp Thr Asn Thr Ser Ala Asn 
        115                 120                 125             


Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ser Leu Gly 
    130                 135                 140                 


Leu Ala His Ser Ser Asp Pro Gly Ala Leu Met Tyr Pro Asn Tyr Ala 
145                 150                 155                 160 


Phe Arg Glu Thr Ser Asn Tyr Ser Leu Pro Gln Asp Asp Ile Asp Gly 
                165                 170                 175     


Ile Gln Ala Ile Tyr Gly Leu Ser Ser Asn Pro Ile Gln Pro Thr Gly 
            180                 185                 190         


Pro Ser Thr Pro Lys Pro Cys Asp Pro Ser Leu Thr Phe Asp Ala Ile 
        195                 200                 205             


Thr Thr Leu Arg Gly Glu Ile Leu Phe Phe Lys Asp Arg Tyr Phe Trp 
    210                 215                 220                 


Arg Arg His Pro Gln Leu Gln Arg Val Glu Met Asn Phe Ile Ser Leu 
225                 230                 235                 240 


Phe Trp Pro Ser Leu Pro Thr Gly Ile Gln Ala Ala Tyr Glu Asp Phe 
                245                 250                 255     


Asp Arg Asp Leu Ile Phe Leu Phe Lys Gly Asn Gln Tyr Trp Ala Leu 
            260                 265                 270         


Ser Gly Tyr Asp Ile Leu Gln Gly Tyr Pro Lys Asp Ile Ser Asn Tyr 
        275                 280                 285             


Gly Phe Pro Ser Ser Val Gln Ala Ile Asp Ala Ala Val Phe Tyr Arg 
    290                 295                 300                 


Ser Lys Thr Tyr Phe Phe Val Asn Asp Gln Phe Trp Arg Tyr Asp Asn 
305                 310                 315                 320 


Gln Arg Gln Phe Met Glu Pro Gly Tyr Pro Lys Ser Ile Ser Gly Ala 
                325                 330                 335     


Phe Pro Gly Ile Glu Ser Lys Val Asp Ala Val Phe Gln Gln Glu His 
            340                 345                 350         


Phe Phe His Val Phe Ser Gly Pro Arg Tyr Tyr Ala Phe Asp Leu Ile 
        355                 360                 365             


Ala Gln Arg Val Thr Arg Val Ala Arg Gly Asn Lys Trp Leu Asn Cys 
    370                 375                 380                 


Arg Tyr Gly 
385         


<210>  18
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Lys Ser Leu Pro Ile Leu Leu Leu Leu Cys Val Ala Val Cys Ser 
1               5                   10                  15      


Ala Phe Arg Thr Phe Pro Gly Ile Pro Lys Trp Arg Lys Thr His Leu 
            20                  25                  30          


Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Lys Asp Ala Val 
        35                  40                  45              


Asp Ser Ala Val Glu Lys Ala Leu Lys Val Trp Glu Glu Val Thr Pro 
    50                  55                  60                  


Leu Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met Ile Ser 
65                  70                  75                  80  


Phe Ala Val Arg Glu His Gly Asp Phe Tyr Pro Phe Asp Gly Pro Gly 
                85                  90                  95      


Asn Val Leu Ala His Ala Tyr Ala Pro Gly Pro Gly Ile Asn Gly Asp 
            100                 105                 110         


Ala His Phe Asp Asp Asp Glu Gln Trp Thr Lys Asp Thr Thr Gly Thr 
        115                 120                 125             


Asn Leu Phe Leu Val Ala Ala His Glu Ile Gly His Ser Leu Gly Leu 
    130                 135                 140                 


Phe His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr His Ser 
145                 150                 155                 160 


Leu Thr Asp Leu Thr Arg Phe Arg Leu Ser Gln Asp Asp Ile Asn Gly 
                165                 170                 175     


Ile Gln Ser Leu Tyr Gly Pro Pro Pro Asp Ser Pro Glu Thr Pro Leu 
            180                 185                 190         


Val Pro Thr Glu Pro Val Pro Pro Glu Pro Gly Thr Pro Ala Asn Cys 
        195                 200                 205             


Asp Pro Ala Leu Ser Phe Asp Ala Val Ser Thr Leu Arg Gly Glu Ile 
    210                 215                 220                 


Leu Ile Phe Lys Asp Arg His Phe Trp Arg Lys Ser Leu Arg Lys Leu 
225                 230                 235                 240 


Glu Pro Glu Leu His Leu Ile Ser Ser Phe Trp Pro Ser Leu Pro Ser 
                245                 250                 255     


Gly Val Asp Ala Ala Tyr Glu Val Thr Ser Lys Asp Leu Val Phe Ile 
            260                 265                 270         


Phe Lys Gly Asn Gln Phe Trp Ala Ile Arg Gly Asn Glu Val Arg Ala 
        275                 280                 285             


Gly Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro Thr Val Arg 
    290                 295                 300                 


Lys Ile Asp Ala Ala Ile Ser Asp Lys Glu Lys Asn Lys Thr Tyr Phe 
305                 310                 315                 320 


Phe Val Glu Asp Lys Tyr Trp Arg Phe Asp Glu Lys Arg Asn Ser Met 
                325                 330                 335     


Glu Pro Gly Phe Pro Lys Gln Ile Ala Glu Asp Phe Pro Gly Ile Asp 
            340                 345                 350         


Ser Lys Ile Asp Ala Val Phe Glu Glu Phe Gly Phe Phe Tyr Phe Phe 
        355                 360                 365             


Thr Gly Ser Ser Gln Leu Glu Phe Asp Pro Asn Ala Lys Lys Val Thr 
    370                 375                 380                 


His Thr Leu Lys Ser Asn Ser Trp Leu Asn Cys 
385                 390                 395 


<210>  19
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Val Val Gly Gly Cys Val Ala His Pro His Ser Trp Pro 
            20                  25                  30          


Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly Gly 
        35                  40                  45              


Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu Glu 
    50                  55                  60                  


Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His Gln 
65                  70                  75                  80  


Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg Leu 
                85                  90                  95      


Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser Ser 
            100                 105                 110         


Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser Pro 
        115                 120                 125             


Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp Gly 
    130                 135                 140                 


Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln Leu 
145                 150                 155                 160 


Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn Gly 
                165                 170                 175     


Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly Thr 
            180                 185                 190         


Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu Lys 
        195                 200                 205             


Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys Ala 
    210                 215                 220                 


Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val Thr 
225                 230                 235                 240 


Trp Ile Glu Gly Val Met Arg Asn Asn 
                245                 


<210>  20
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


Gly Ala Arg Ser Tyr Gln Val Ile Cys Arg Asp Glu Lys Thr Gln Met 
        35                  40                  45              


Ile Tyr Gln Gln His Gln Ser Trp Leu Arg Pro Val Leu Arg Ser Asn 
    50                  55                  60                  


Arg Val Glu Tyr Cys Trp Cys Asn Ser Gly Arg Ala Gln Cys His Ser 
65                  70                  75                  80  


Val Pro Val Lys Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr 
                85                  90                  95      


Cys Gln Gln Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Glu 
            100                 105                 110         


Gly Phe Ala Gly Lys Cys Cys Glu Ile Asp Thr Arg Ala Thr Cys Tyr 
        115                 120                 125             


Glu Asp Gln Gly Ile Ser Tyr Arg Gly Thr Trp Ser Thr Ala Glu Ser 
    130                 135                 140                 


Gly Ala Glu Cys Thr Asn Trp Asn Ser Ser Ala Leu Ala Gln Lys Pro 
145                 150                 155                 160 


Tyr Ser Gly Arg Arg Pro Asp Ala Ile Arg Leu Gly Leu Gly Asn His 
                165                 170                 175     


Asn Tyr Cys Arg Asn Pro Asp Arg Asp Ser Lys Pro Trp Cys Tyr Val 
            180                 185                 190         


Phe Lys Ala Gly Lys Tyr Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys 
        195                 200                 205             


Ser Glu Gly Asn Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg 
    210                 215                 220                 


Gly Thr His Ser Leu Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn 
225                 230                 235                 240 


Ser Met Ile Leu Ile Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser Ala 
                245                 250                 255     


Gln Ala Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Gly 
            260                 265                 270         


Asp Ala Lys Pro Trp Cys His Val Leu Lys Asn Arg Arg Leu Thr Trp 
        275                 280                 285             


Glu Tyr Cys Asp Val Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln Tyr 
    290                 295                 300                 


Ser Gln Pro Gln Phe Arg Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala 
305                 310                 315                 320 


Ser His Pro Trp Gln Ala Ala Ile Phe Ala Lys His Arg Arg Ser Pro 
                325                 330                 335     


Gly Glu Arg Phe Leu Cys Gly Gly Ile Leu Ile Ser Ser Cys Trp Ile 
            340                 345                 350         


Leu Ser Ala Ala His Cys Phe Gln Glu Arg Phe Pro Pro His His Leu 
        355                 360                 365             


Thr Val Ile Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu 
    370                 375                 380                 


Gln Lys Phe Glu Val Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp 
385                 390                 395                 400 


Asp Thr Tyr Asp Asn Asp Ile Ala Leu Leu Gln Leu Lys Ser Asp Ser 
                405                 410                 415     


Ser Arg Cys Ala Gln Glu Ser Ser Val Val Arg Thr Val Cys Leu Pro 
            420                 425                 430         


Pro Ala Asp Leu Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly 
        435                 440                 445             


Tyr Gly Lys His Glu Ala Leu Ser Pro Phe Tyr Ser Glu Arg Leu Lys 
    450                 455                 460                 


Glu Ala His Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His 
465                 470                 475                 480 


Leu Leu Asn Arg Thr Val Thr Asp Asn Met Leu Cys Ala Gly Asp Thr 
                485                 490                 495     


Arg Ser Gly Gly Pro Gln Ala Asn Leu His Asp Ala Cys Gln Gly Asp 
            500                 505                 510         


Ser Gly Gly Pro Leu Val Cys Leu Asn Asp Gly Arg Met Thr Leu Val 
        515                 520                 525             


Gly Ile Ile Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly 
    530                 535                 540                 


Val Tyr Thr Lys Val Thr Asn Tyr Leu Asp Trp Ile Arg Asp Asn Met 
545                 550                 555                 560 


Arg Pro 
        


<210>  21
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Arg Ala Leu Leu Ala Arg Leu Leu Leu Cys Val Leu Val Val Ser 
1               5                   10                  15      


Asp Ser Lys Gly Ser Asn Glu Leu His Gln Val Pro Ser Asn Cys Asp 
            20                  25                  30          


Cys Leu Asn Gly Gly Thr Cys Val Ser Asn Lys Tyr Phe Ser Asn Ile 
        35                  40                  45              


His Trp Cys Asn Cys Pro Lys Lys Phe Gly Gly Gln His Cys Glu Ile 
    50                  55                  60                  


Asp Lys Ser Lys Thr Cys Tyr Glu Gly Asn Gly His Phe Tyr Arg Gly 
65                  70                  75                  80  


Lys Ala Ser Thr Asp Thr Met Gly Arg Pro Cys Leu Pro Trp Asn Ser 
                85                  90                  95      


Ala Thr Val Leu Gln Gln Thr Tyr His Ala His Arg Ser Asp Ala Leu 
            100                 105                 110         


Gln Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Asn Arg 
        115                 120                 125             


Arg Arg Pro Trp Cys Tyr Val Gln Val Gly Leu Lys Pro Leu Val Gln 
    130                 135                 140                 


Glu Cys Met Val His Asp Cys Ala Asp Gly Lys Lys Pro Ser Ser Pro 
145                 150                 155                 160 


Pro Glu Glu Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg 
                165                 170                 175     


Phe Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp 
            180                 185                 190         


Phe Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val 
        195                 200                 205             


Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His 
    210                 215                 220                 


Cys Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly 
225                 230                 235                 240 


Arg Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val 
                245                 250                 255     


Glu Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His 
            260                 265                 270         


His Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys 
        275                 280                 285             


Ala Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr 
    290                 295                 300                 


Asn Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys 
305                 310                 315                 320 


Glu Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val 
                325                 330                 335     


Val Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly 
            340                 345                 350         


Ser Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys 
        355                 360                 365             


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu 
    370                 375                 380                 


Gln Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys 
385                 390                 395                 400 


Ala Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu 
                405                 410                 415     


Pro Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
            420                 425                 430     


<210>  22
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210>  23
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  23

Met His Ser Phe Pro Pro Leu Leu Leu Leu Leu Phe Trp Gly Val Val 
1               5                   10                  15      


Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp 
            20                  25                  30          


Leu Val Gln Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly 
        35                  40                  45              


Arg Gln Val Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu 
    50                  55                  60                  


Lys Gln Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp 
65                  70                  75                  80  


Ala Glu Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val Ala Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr 
            100                 105                 110         


His Leu Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala 
        115                 120                 125             


Asp Val Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val 
    130                 135                 140                 


Thr Pro Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met 
145                 150                 155                 160 


Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly 
                165                 170                 175     


Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly 
            180                 185                 190         


Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg 
        195                 200                 205             


Glu Tyr Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr 
225                 230                 235                 240 


Thr Phe Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile 
                245                 250                 255     


Gln Ala Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro 
            260                 265                 270         


Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr 
        275                 280                 285             


Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg 
    290                 295                 300                 


Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe 
305                 310                 315                 320 


Trp Pro Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp 
                325                 330                 335     


Arg Asp Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln 
            340                 345                 350         


Gly Gln Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe 
        355                 360                 365             


Gly Phe Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu 
    370                 375                 380                 


Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr 
385                 390                 395                 400 


Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala 
                405                 410                 415     


His Asp Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys 
            420                 425                 430         


Asp Gly Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp 
        435                 440                 445             


Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe 
    450                 455                 460                 


Asn Cys Arg Lys Asn 
465                 


<210>  24
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Met His Leu Ala Phe Leu Val Leu Leu Cys Leu Pro Val Cys Ser 
1               5                   10                  15      


Ala Tyr Pro Leu Ser Gly Ala Ala Lys Glu Glu Asp Ser Asn Lys Asp 
            20                  25                  30          


Leu Ala Gln Gln Tyr Leu Glu Lys Tyr Tyr Asn Leu Glu Lys Asp Val 
        35                  40                  45              


Lys Gln Phe Arg Arg Lys Asp Ser Asn Leu Ile Val Lys Lys Ile Gln 
    50                  55                  60                  


Gly Met Gln Lys Phe Leu Gly Leu Glu Val Thr Gly Lys Leu Asp Thr 
65                  70                  75                  80  


Asp Thr Leu Glu Val Met Arg Lys Pro Arg Cys Gly Val Pro Asp Val 
                85                  90                  95      


Gly His Phe Ser Ser Phe Pro Gly Met Pro Lys Trp Arg Lys Thr His 
            100                 105                 110         


Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Arg Asp Ala 
        115                 120                 125             


Val Asp Ser Ala Ile Glu Lys Ala Leu Lys Val Trp Glu Glu Val Thr 
    130                 135                 140                 


Pro Leu Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met Ile 
145                 150                 155                 160 


Ser Phe Ala Val Lys Glu His Gly Asp Phe Tyr Ser Phe Asp Gly Pro 
                165                 170                 175     


Gly His Ser Leu Ala His Ala Tyr Pro Pro Gly Pro Gly Leu Tyr Gly 
            180                 185                 190         


Asp Ile His Phe Asp Asp Asp Glu Lys Trp Thr Glu Asp Ala Ser Gly 
        195                 200                 205             


Thr Asn Leu Phe Leu Val Ala Ala His Glu Leu Gly His Ser Leu Gly 
    210                 215                 220                 


Leu Phe His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr Asn 
225                 230                 235                 240 


Ser Phe Thr Glu Leu Ala Gln Phe Arg Leu Ser Gln Asp Asp Val Asn 
                245                 250                 255     


Gly Ile Gln Ser Leu Tyr Gly Pro Pro Pro Ala Ser Thr Glu Glu Pro 
            260                 265                 270         


Leu Val Pro Thr Lys Ser Val Pro Ser Gly Ser Glu Met Pro Ala Lys 
        275                 280                 285             


Cys Asp Pro Ala Leu Ser Phe Asp Ala Ile Ser Thr Leu Arg Gly Glu 
    290                 295                 300                 


Tyr Leu Phe Phe Lys Asp Arg Tyr Phe Trp Arg Arg Ser His Trp Asn 
305                 310                 315                 320 


Pro Glu Pro Glu Phe His Leu Ile Ser Ala Phe Trp Pro Ser Leu Pro 
                325                 330                 335     


Ser Tyr Leu Asp Ala Ala Tyr Glu Val Asn Ser Arg Asp Thr Val Phe 
            340                 345                 350         


Ile Phe Lys Gly Asn Glu Phe Trp Ala Ile Arg Gly Asn Glu Val Gln 
        355                 360                 365             


Ala Gly Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro Thr Ile 
    370                 375                 380                 


Arg Lys Ile Asp Ala Ala Val Ser Asp Lys Glu Lys Lys Lys Thr Tyr 
385                 390                 395                 400 


Phe Phe Ala Ala Asp Lys Tyr Trp Arg Phe Asp Glu Asn Ser Gln Ser 
                405                 410                 415     


Met Glu Gln Gly Phe Pro Arg Leu Ile Ala Asp Asp Phe Pro Gly Val 
            420                 425                 430         


Glu Pro Lys Val Asp Ala Val Leu Gln Ala Phe Gly Phe Phe Tyr Phe 
        435                 440                 445             


Phe Ser Gly Ser Ser Gln Phe Glu Phe Asp Pro Asn Ala Arg Met Val 
    450                 455                 460                 


Thr His Ile Leu Lys Ser Asn Ser Trp Leu His Cys 
465                 470                 475     


<210>  25
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Met His Leu Ala Phe Leu Val Leu Leu Cys Leu Pro Val Cys Ser 
1               5                   10                  15      


Ala Tyr Pro Leu Ser Gly Ala Ala Lys Glu Glu Asp Ser Asn Lys Asp 
            20                  25                  30          


Leu Ala Gln Gln Tyr Leu Glu Lys Tyr Tyr Asn Leu Glu Lys Asp Val 
        35                  40                  45              


Lys Gln Phe Arg Arg Lys Asp Ser Asn Leu Ile Val Lys Lys Ile Gln 
    50                  55                  60                  


Gly Met Gln Lys Phe Leu Gly Leu Glu Val Thr Gly Lys Leu Asp Thr 
65                  70                  75                  80  


Asp Thr Leu Glu Val Met Arg Lys Pro Arg Cys Gly Val Pro Asp Val 
                85                  90                  95      


Gly His Phe Ser Ser Phe Pro Gly Met Pro Lys Trp Arg Lys Thr His 
            100                 105                 110         


Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Arg Asp Ala 
        115                 120                 125             


Val Asp Ser Ala Ile Glu Lys Ala Leu Lys Val Trp Glu Glu Val Thr 
    130                 135                 140                 


Pro Leu Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met Ile 
145                 150                 155                 160 


Ser Phe Ala Val Lys Glu His Gly Asp Phe Tyr Ser Phe Asp Gly Pro 
                165                 170                 175     


Gly His Ser Leu Ala His Ala Tyr Pro Pro Gly Pro Gly Leu Tyr Gly 
            180                 185                 190         


Asp Ile His Phe Asp Asp Asp Glu Lys Trp Thr Glu Asp Ala Ser Gly 
        195                 200                 205             


Thr Asn Leu Phe Leu Val Ala Ala His Glu Leu Gly His Ser Leu Gly 
    210                 215                 220                 


Leu Phe His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr Asn 
225                 230                 235                 240 


Ser Phe Thr Glu Leu Ala Gln Phe Arg Leu Ser Gln Asp Asp Val Asn 
                245                 250                 255     


Gly Ile Gln Ser Leu Tyr Gly Pro Pro Pro Ala Ser Thr Glu Glu Pro 
            260                 265                 270         


Leu Val Pro Thr Lys Ser Val Pro Ser Gly Ser Glu Met Pro Ala Lys 
        275                 280                 285             


Cys Asp Pro Ala Leu Ser Phe Asp Ala Ile Ser Thr Leu Arg Gly Glu 
    290                 295                 300                 


Tyr Leu Phe Phe Lys Asp Arg Tyr Phe Trp Arg Arg Ser His Trp Asn 
305                 310                 315                 320 


Pro Glu Pro Glu Phe His Leu Ile Ser Ala Phe Trp Pro Ser Leu Pro 
                325                 330                 335     


Ser Tyr Leu Asp Ala Ala Tyr Glu Val Asn Ser Arg Asp Thr Val Phe 
            340                 345                 350         


Ile Phe Lys Gly Asn Glu Phe Trp Ala Ile Arg Gly Asn Glu Val Gln 
        355                 360                 365             


Ala Gly Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro Thr Ile 
    370                 375                 380                 


Arg Lys Ile Asp Ala Ala Val Ser Asp Lys Glu Lys Lys Lys Thr Tyr 
385                 390                 395                 400 


Phe Phe Ala Ala Asp Lys Tyr Trp Arg Phe Asp Glu Asn Ser Gln Ser 
                405                 410                 415     


Met Glu Gln Gly Phe Pro Arg Leu Ile Ala Asp Asp Phe Pro Gly Val 
            420                 425                 430         


Glu Pro Lys Val Asp Ala Val Leu Gln Ala Phe Gly Phe Phe Tyr Phe 
        435                 440                 445             


Phe Ser Gly Ser Ser Gln Phe Glu Phe Asp Pro Asn Ala Arg Met Val 
    450                 455                 460                 


Thr His Ile Leu Lys Ser Asn Ser Trp Leu His Cys 
465                 470                 475     


<210>  26
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Lys Phe Leu Leu Ile Leu Leu Leu Gln Ala Thr Ala Ser Gly Ala 
1               5                   10                  15      


Leu Pro Leu Asn Ser Ser Thr Ser Leu Glu Lys Asn Asn Val Leu Phe 
            20                  25                  30          


Gly Glu Arg Tyr Leu Glu Lys Phe Tyr Gly Leu Glu Ile Asn Lys Leu 
        35                  40                  45              


Pro Val Thr Lys Met Lys Tyr Ser Gly Asn Leu Met Lys Glu Lys Ile 
    50                  55                  60                  


Gln Glu Met Gln His Phe Leu Gly Leu Lys Val Thr Gly Gln Leu Asp 
65                  70                  75                  80  


Thr Ser Thr Leu Glu Met Met His Ala Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val His His Phe Arg Glu Met Pro Gly Gly Pro Val Trp Arg Lys His 
            100                 105                 110         


Tyr Ile Thr Tyr Arg Ile Asn Asn Tyr Thr Pro Asp Met Asn Arg Glu 
        115                 120                 125             


Asp Val Asp Tyr Ala Ile Arg Lys Ala Phe Gln Val Trp Ser Asn Val 
    130                 135                 140                 


Thr Pro Leu Lys Phe Ser Lys Ile Asn Thr Gly Met Ala Asp Ile Leu 
145                 150                 155                 160 


Val Val Phe Ala Arg Gly Ala His Gly Asp Phe His Ala Phe Asp Gly 
                165                 170                 175     


Lys Gly Gly Ile Leu Ala His Ala Phe Gly Pro Gly Ser Gly Ile Gly 
            180                 185                 190         


Gly Asp Ala His Phe Asp Glu Asp Glu Phe Trp Thr Thr His Ser Gly 
        195                 200                 205             


Gly Thr Asn Leu Phe Leu Thr Ala Val His Glu Ile Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Gly His Ser Ser Asp Pro Lys Ala Val Met Phe Pro Thr Tyr 
225                 230                 235                 240 


Lys Tyr Val Asp Ile Asn Thr Phe Arg Leu Ser Ala Asp Asp Ile Arg 
                245                 250                 255     


Gly Ile Gln Ser Leu Tyr Gly Asp Pro Lys Glu Asn Gln Arg Leu Pro 
            260                 265                 270         


Asn Pro Asp Asn Ser Glu Pro Ala Leu Cys Asp Pro Asn Leu Ser Phe 
        275                 280                 285             


Asp Ala Val Thr Thr Val Gly Asn Lys Ile Phe Phe Phe Lys Asp Arg 
    290                 295                 300                 


Phe Phe Trp Leu Lys Val Ser Glu Arg Pro Lys Thr Ser Val Asn Leu 
305                 310                 315                 320 


Ile Ser Ser Leu Trp Pro Thr Leu Pro Ser Gly Ile Glu Ala Ala Tyr 
                325                 330                 335     


Glu Ile Glu Ala Arg Asn Gln Val Phe Leu Phe Lys Asp Asp Lys Tyr 
            340                 345                 350         


Trp Leu Ile Ser Asn Leu Arg Pro Glu Pro Asn Tyr Pro Lys Ser Ile 
        355                 360                 365             


His Ser Phe Gly Phe Pro Asn Phe Val Lys Lys Ile Asp Ala Ala Val 
    370                 375                 380                 


Phe Asn Pro Arg Phe Tyr Arg Thr Tyr Phe Phe Val Asp Asn Gln Tyr 
385                 390                 395                 400 


Trp Arg Tyr Asp Glu Arg Arg Gln Met Met Asp Pro Gly Tyr Pro Lys 
                405                 410                 415     


Leu Ile Thr Lys Asn Phe Gln Gly Ile Gly Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Phe Tyr Ser Lys Asn Lys Tyr Tyr Tyr Phe Phe Gln Gly Ser Asn Gln 
        435                 440                 445             


Phe Glu Tyr Asp Phe Leu Leu Gln Arg Ile Thr Lys Thr Leu Lys Ser 
    450                 455                 460                 


Asn Ser Trp Phe Gly Cys 
465                 470 


<210>  27
<211>  582
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ser Pro Ala Pro Arg Pro Pro Arg Cys Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Thr Leu Gly Thr Ala Leu Ala Ser Leu Gly Ser Ala Gln Ser Ser Ser 
            20                  25                  30          


Phe Ser Pro Glu Ala Trp Leu Gln Gln Tyr Gly Tyr Leu Pro Pro Gly 
        35                  40                  45              


Asp Leu Arg Thr His Thr Gln Arg Ser Pro Gln Ser Leu Ser Ala Ala 
    50                  55                  60                  


Ile Ala Ala Met Gln Lys Phe Tyr Gly Leu Gln Val Thr Gly Lys Ala 
65                  70                  75                  80  


Asp Ala Asp Thr Met Lys Ala Met Arg Arg Pro Arg Cys Gly Val Pro 
                85                  90                  95      


Asp Lys Phe Gly Ala Glu Ile Lys Ala Asn Val Arg Arg Lys Arg Tyr 
            100                 105                 110         


Ala Ile Gln Gly Leu Lys Trp Gln His Asn Glu Ile Thr Phe Cys Ile 
        115                 120                 125             


Gln Asn Tyr Thr Pro Lys Val Gly Glu Tyr Ala Thr Tyr Glu Ala Ile 
    130                 135                 140                 


Arg Lys Ala Phe Arg Val Trp Glu Ser Ala Thr Pro Leu Arg Phe Arg 
145                 150                 155                 160 


Glu Val Pro Tyr Ala Tyr Ile Arg Glu Gly His Glu Lys Gln Ala Asp 
                165                 170                 175     


Ile Met Ile Phe Phe Ala Glu Gly Phe His Gly Asp Ser Thr Pro Phe 
            180                 185                 190         


Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Asn 
        195                 200                 205             


Ile Gly Gly Asp Thr His Phe Asp Ser Ala Glu Pro Trp Thr Val Arg 
    210                 215                 220                 


Asn Glu Asp Leu Asn Gly Asn Asp Ile Phe Leu Val Ala Val His Glu 
225                 230                 235                 240 


Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asp Pro Ser Ala Ile 
                245                 250                 255     


Met Ala Pro Phe Tyr Gln Trp Met Asp Thr Glu Asn Phe Val Leu Pro 
            260                 265                 270         


Asp Asp Asp Arg Arg Gly Ile Gln Gln Leu Tyr Gly Gly Glu Ser Gly 
        275                 280                 285             


Phe Pro Thr Lys Met Pro Pro Gln Pro Arg Thr Thr Ser Arg Pro Ser 
    290                 295                 300                 


Val Pro Asp Lys Pro Lys Asn Pro Thr Tyr Gly Pro Asn Ile Cys Asp 
305                 310                 315                 320 


Gly Asn Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met Phe Val Phe 
                325                 330                 335     


Lys Glu Arg Trp Phe Trp Arg Val Arg Asn Asn Gln Val Met Asp Gly 
            340                 345                 350         


Tyr Pro Met Pro Ile Gly Gln Phe Trp Arg Gly Leu Pro Ala Ser Ile 
        355                 360                 365             


Asn Thr Ala Tyr Glu Arg Lys Asp Gly Lys Phe Val Phe Phe Lys Gly 
    370                 375                 380                 


Asp Lys His Trp Val Phe Asp Glu Ala Ser Leu Glu Pro Gly Tyr Pro 
385                 390                 395                 400 


Lys His Ile Lys Glu Leu Gly Arg Gly Leu Pro Thr Asp Lys Ile Asp 
                405                 410                 415     


Ala Ala Leu Phe Trp Met Pro Asn Gly Lys Thr Tyr Phe Phe Arg Gly 
            420                 425                 430         


Asn Lys Tyr Tyr Arg Phe Asn Glu Glu Leu Arg Ala Val Asp Ser Glu 
        435                 440                 445             


Tyr Pro Lys Asn Ile Lys Val Trp Glu Gly Ile Pro Glu Ser Pro Arg 
    450                 455                 460                 


Gly Ser Phe Met Gly Ser Asp Glu Val Phe Thr Tyr Phe Tyr Lys Gly 
465                 470                 475                 480 


Asn Lys Tyr Trp Lys Phe Asn Asn Gln Lys Leu Lys Val Glu Pro Gly 
                485                 490                 495     


Tyr Pro Lys Ser Ala Leu Arg Asp Trp Met Gly Cys Pro Ser Gly Gly 
            500                 505                 510         


Arg Pro Asp Glu Gly Thr Glu Glu Glu Thr Glu Val Ile Ile Ile Glu 
        515                 520                 525             


Val Asp Glu Glu Gly Gly Gly Ala Val Ser Ala Ala Ala Val Val Leu 
    530                 535                 540                 


Pro Val Leu Leu Leu Leu Leu Val Leu Ala Val Gly Leu Ala Val Phe 
545                 550                 555                 560 


Phe Phe Arg Arg His Gly Thr Pro Arg Arg Leu Leu Tyr Cys Gln Arg 
                565                 570                 575     


Ser Leu Leu Asp Lys Val 
            580         


<210>  28
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Gly Ser Asp Pro Ser Ala Pro Gly Arg Pro Gly Trp Thr Gly Ser 
1               5                   10                  15      


Leu Leu Gly Asp Arg Glu Glu Ala Ala Arg Pro Arg Leu Leu Pro Leu 
            20                  25                  30          


Leu Leu Val Leu Leu Gly Cys Leu Gly Leu Gly Val Ala Ala Glu Asp 
        35                  40                  45              


Ala Glu Val His Ala Glu Asn Trp Leu Arg Leu Tyr Gly Tyr Leu Pro 
    50                  55                  60                  


Gln Pro Ser Arg His Met Ser Thr Met Arg Ser Ala Gln Ile Leu Ala 
65                  70                  75                  80  


Ser Ala Leu Ala Glu Met Gln Arg Phe Tyr Gly Ile Pro Val Thr Gly 
                85                  90                  95      


Val Leu Asp Glu Glu Thr Lys Glu Trp Met Lys Arg Pro Arg Cys Gly 
            100                 105                 110         


Val Pro Asp Gln Phe Gly Val Arg Val Lys Ala Asn Leu Arg Arg Arg 
        115                 120                 125             


Arg Lys Arg Tyr Ala Leu Thr Gly Arg Lys Trp Asn Asn His His Leu 
    130                 135                 140                 


Thr Phe Ser Ile Gln Asn Tyr Thr Glu Lys Leu Gly Trp Tyr His Ser 
145                 150                 155                 160 


Met Glu Ala Val Arg Arg Ala Phe Arg Val Trp Glu Gln Ala Thr Pro 
                165                 170                 175     


Leu Val Phe Gln Glu Val Pro Tyr Glu Asp Ile Arg Leu Arg Arg Gln 
            180                 185                 190         


Lys Glu Ala Asp Ile Met Val Leu Phe Ala Ser Gly Phe His Gly Asp 
        195                 200                 205             


Ser Ser Pro Phe Asp Gly Thr Gly Gly Phe Leu Ala His Ala Tyr Phe 
    210                 215                 220                 


Pro Gly Pro Gly Leu Gly Gly Asp Thr His Phe Asp Ala Asp Glu Pro 
225                 230                 235                 240 


Trp Thr Phe Ser Ser Thr Asp Leu His Gly Asn Asn Leu Phe Leu Val 
                245                 250                 255     


Ala Val His Glu Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asn 
            260                 265                 270         


Pro Asn Ala Ile Met Ala Pro Phe Tyr Gln Trp Lys Asp Val Asp Asn 
        275                 280                 285             


Phe Lys Leu Pro Glu Asp Asp Leu Arg Gly Ile Gln Gln Leu Tyr Gly 
    290                 295                 300                 


Thr Pro Asp Gly Gln Pro Gln Pro Thr Gln Pro Leu Pro Thr Val Thr 
305                 310                 315                 320 


Pro Arg Arg Pro Gly Arg Pro Asp His Arg Pro Pro Arg Pro Pro Gln 
                325                 330                 335     


Pro Pro Pro Pro Gly Gly Lys Pro Glu Arg Pro Pro Lys Pro Gly Pro 
            340                 345                 350         


Pro Val Gln Pro Arg Ala Thr Glu Arg Pro Asp Gln Tyr Gly Pro Asn 
        355                 360                 365             


Ile Cys Asp Gly Asp Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met 
    370                 375                 380                 


Phe Val Phe Lys Gly Arg Trp Phe Trp Arg Val Arg His Asn Arg Val 
385                 390                 395                 400 


Leu Asp Asn Tyr Pro Met Pro Ile Gly His Phe Trp Arg Gly Leu Pro 
                405                 410                 415     


Gly Asp Ile Ser Ala Ala Tyr Glu Arg Gln Asp Gly Arg Phe Val Phe 
            420                 425                 430         


Phe Lys Gly Asp Arg Tyr Trp Leu Phe Arg Glu Ala Asn Leu Glu Pro 
        435                 440                 445             


Gly Tyr Pro Gln Pro Leu Thr Ser Tyr Gly Leu Gly Ile Pro Tyr Asp 
    450                 455                 460                 


Arg Ile Asp Thr Ala Ile Trp Trp Glu Pro Thr Gly His Thr Phe Phe 
465                 470                 475                 480 


Phe Gln Glu Asp Arg Tyr Trp Arg Phe Asn Glu Glu Thr Gln Arg Gly 
                485                 490                 495     


Asp Pro Gly Tyr Pro Lys Pro Ile Ser Val Trp Gln Gly Ile Pro Ala 
            500                 505                 510         


Ser Pro Lys Gly Ala Phe Leu Ser Asn Asp Ala Ala Tyr Thr Tyr Phe 
        515                 520                 525             


Tyr Lys Gly Thr Lys Tyr Trp Lys Phe Asp Asn Glu Arg Leu Arg Met 
    530                 535                 540                 


Glu Pro Gly Tyr Pro Lys Ser Ile Leu Arg Asp Phe Met Gly Cys Gln 
545                 550                 555                 560 


Glu His Val Glu Pro Gly Pro Arg Trp Pro Asp Val Ala Arg Pro Pro 
                565                 570                 575     


Phe Asn Pro His Gly Gly Ala Glu Pro Gly Ala Asp Ser Ala Glu Gly 
            580                 585                 590         


Asp Val Gly Asp Gly Asp Gly Asp Phe Gly Ala Gly Val Asn Lys Asp 
        595                 600                 605             


Gly Gly Ser Arg Val Val Val Gln Met Glu Glu Val Ala Arg Thr Val 
    610                 615                 620                 


Asn Val Val Met Val Leu Val Pro Leu Leu Leu Leu Leu Cys Val Leu 
625                 630                 635                 640 


Gly Leu Thr Tyr Ala Leu Val Gln Met Gln Arg Lys Gly Ala Pro Arg 
                645                 650                 655     


Val Leu Leu Tyr Cys Lys Arg Ser Leu Gln Glu Trp Val 
            660                 665                 


<210>  29
<211>  607
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ile Leu Leu Thr Phe Ser Thr Gly Arg Arg Leu Asp Phe Val His 
1               5                   10                  15      


His Ser Gly Val Phe Phe Leu Gln Thr Leu Leu Trp Ile Leu Cys Ala 
            20                  25                  30          


Thr Val Cys Gly Thr Glu Gln Tyr Phe Asn Val Glu Val Trp Leu Gln 
        35                  40                  45              


Lys Tyr Gly Tyr Leu Pro Pro Thr Asp Pro Arg Met Ser Val Leu Arg 
    50                  55                  60                  


Ser Ala Glu Thr Met Gln Ser Ala Leu Ala Ala Met Gln Gln Phe Tyr 
65                  70                  75                  80  


Gly Ile Asn Met Thr Gly Lys Val Asp Arg Asn Thr Ile Asp Trp Met 
                85                  90                  95      


Lys Lys Pro Arg Cys Gly Val Pro Asp Gln Thr Arg Gly Ser Ser Lys 
            100                 105                 110         


Phe His Ile Arg Arg Lys Arg Tyr Ala Leu Thr Gly Gln Lys Trp Gln 
        115                 120                 125             


His Lys His Ile Thr Tyr Ser Ile Lys Asn Val Thr Pro Lys Val Gly 
    130                 135                 140                 


Asp Pro Glu Thr Arg Lys Ala Ile Arg Arg Ala Phe Asp Val Trp Gln 
145                 150                 155                 160 


Asn Val Thr Pro Leu Thr Phe Glu Glu Val Pro Tyr Ser Glu Leu Glu 
                165                 170                 175     


Asn Gly Lys Arg Asp Val Asp Ile Thr Ile Ile Phe Ala Ser Gly Phe 
            180                 185                 190         


His Gly Asp Ser Ser Pro Phe Asp Gly Glu Gly Gly Phe Leu Ala His 
        195                 200                 205             


Ala Tyr Phe Pro Gly Pro Gly Ile Gly Gly Asp Thr His Phe Asp Ser 
    210                 215                 220                 


Asp Glu Pro Trp Thr Leu Gly Asn Pro Asn His Asp Gly Asn Asp Leu 
225                 230                 235                 240 


Phe Leu Val Ala Val His Glu Leu Gly His Ala Leu Gly Leu Glu His 
                245                 250                 255     


Ser Asn Asp Pro Thr Ala Ile Met Ala Pro Phe Tyr Gln Tyr Met Glu 
            260                 265                 270         


Thr Asp Asn Phe Lys Leu Pro Asn Asp Asp Leu Gln Gly Ile Gln Lys 
        275                 280                 285             


Ile Tyr Gly Pro Pro Asp Lys Ile Pro Pro Pro Thr Arg Pro Leu Pro 
    290                 295                 300                 


Thr Val Pro Pro His Arg Ser Ile Pro Pro Ala Asp Pro Arg Lys Asn 
305                 310                 315                 320 


Asp Arg Pro Lys Pro Pro Arg Pro Pro Thr Gly Arg Pro Ser Tyr Pro 
                325                 330                 335     


Gly Ala Lys Pro Asn Ile Cys Asp Gly Asn Phe Asn Thr Leu Ala Ile 
            340                 345                 350         


Leu Arg Arg Glu Met Phe Val Phe Lys Asp Gln Trp Phe Trp Arg Val 
        355                 360                 365             


Arg Asn Asn Arg Val Met Asp Gly Tyr Pro Met Gln Ile Thr Tyr Phe 
    370                 375                 380                 


Trp Arg Gly Leu Pro Pro Ser Ile Asp Ala Val Tyr Glu Asn Ser Asp 
385                 390                 395                 400 


Gly Asn Phe Val Phe Phe Lys Gly Asn Lys Tyr Trp Val Phe Lys Asp 
                405                 410                 415     


Thr Thr Leu Gln Pro Gly Tyr Pro His Asp Leu Ile Thr Leu Gly Ser 
            420                 425                 430         


Gly Ile Pro Pro His Gly Ile Asp Ser Ala Ile Trp Trp Glu Asp Val 
        435                 440                 445             


Gly Lys Thr Tyr Phe Phe Lys Gly Asp Arg Tyr Trp Arg Tyr Ser Glu 
    450                 455                 460                 


Glu Met Lys Thr Met Asp Pro Gly Tyr Pro Lys Pro Ile Thr Val Trp 
465                 470                 475                 480 


Lys Gly Ile Pro Glu Ser Pro Gln Gly Ala Phe Val His Lys Glu Asn 
                485                 490                 495     


Gly Phe Thr Tyr Phe Tyr Lys Gly Lys Glu Tyr Trp Lys Phe Asn Asn 
            500                 505                 510         


Gln Ile Leu Lys Val Glu Pro Gly Tyr Pro Arg Ser Ile Leu Lys Asp 
        515                 520                 525             


Phe Met Gly Cys Asp Gly Pro Thr Asp Arg Val Lys Glu Gly His Ser 
    530                 535                 540                 


Pro Pro Asp Asp Val Asp Ile Val Ile Lys Leu Asp Asn Thr Ala Ser 
545                 550                 555                 560 


Thr Val Lys Ala Ile Ala Ile Val Ile Pro Cys Ile Leu Ala Leu Cys 
                565                 570                 575     


Leu Leu Val Leu Val Tyr Thr Val Phe Gln Phe Lys Arg Lys Gly Thr 
            580                 585                 590         


Pro Arg His Ile Leu Tyr Cys Lys Arg Ser Met Gln Glu Trp Val 
        595                 600                 605         


<210>  30
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Arg Arg Arg Ala Ala Arg Gly Pro Gly Pro Pro Pro Pro Gly Pro 
1               5                   10                  15      


Gly Leu Ser Arg Leu Pro Leu Pro Leu Leu Leu Leu Leu Ala Leu Gly 
            20                  25                  30          


Thr Arg Gly Gly Cys Ala Ala Pro Ala Pro Ala Pro Arg Ala Glu Asp 
        35                  40                  45              


Leu Ser Leu Gly Val Glu Trp Leu Ser Arg Phe Gly Tyr Leu Pro Pro 
    50                  55                  60                  


Ala Asp Pro Thr Thr Gly Gln Leu Gln Thr Gln Glu Glu Leu Ser Lys 
65                  70                  75                  80  


Ala Ile Thr Ala Met Gln Gln Phe Gly Gly Leu Glu Ala Thr Gly Ile 
                85                  90                  95      


Leu Asp Glu Ala Thr Leu Ala Leu Met Lys Thr Pro Arg Cys Ser Leu 
            100                 105                 110         


Pro Asp Leu Pro Val Leu Thr Gln Ala Arg Arg Arg Arg Gln Ala Pro 
        115                 120                 125             


Ala Pro Thr Lys Trp Asn Lys Arg Asn Leu Ser Trp Arg Val Arg Thr 
    130                 135                 140                 


Phe Pro Arg Asp Ser Pro Leu Gly His Asp Thr Val Arg Ala Leu Met 
145                 150                 155                 160 


Tyr Tyr Ala Leu Lys Val Trp Ser Asp Ile Ala Pro Leu Asn Phe His 
                165                 170                 175     


Glu Val Ala Gly Ser Ala Ala Asp Ile Gln Ile Asp Phe Ser Lys Ala 
            180                 185                 190         


Asp His Asn Asp Gly Tyr Pro Phe Asp Gly Pro Gly Gly Thr Val Ala 
        195                 200                 205             


His Ala Phe Phe Pro Gly His His His Thr Ala Gly Asp Thr His Phe 
    210                 215                 220                 


Asp Asp Asp Glu Ala Trp Thr Phe Arg Ser Ser Asp Ala His Gly Met 
225                 230                 235                 240 


Asp Leu Phe Ala Val Ala Val His Glu Phe Gly His Ala Ile Gly Leu 
                245                 250                 255     


Ser His Val Ala Ala Ala His Ser Ile Met Arg Pro Tyr Tyr Gln Gly 
            260                 265                 270         


Pro Val Gly Asp Pro Leu Arg Tyr Gly Leu Pro Tyr Glu Asp Lys Val 
        275                 280                 285             


Arg Val Trp Gln Leu Tyr Gly Val Arg Glu Ser Val Ser Pro Thr Ala 
    290                 295                 300                 


Gln Pro Glu Glu Pro Pro Leu Leu Pro Glu Pro Pro Asp Asn Arg Ser 
305                 310                 315                 320 


Ser Ala Pro Pro Arg Lys Asp Val Pro His Arg Cys Ser Thr His Phe 
                325                 330                 335     


Asp Ala Val Ala Gln Ile Arg Gly Glu Ala Phe Phe Phe Lys Gly Lys 
            340                 345                 350         


Tyr Phe Trp Arg Leu Thr Arg Asp Arg His Leu Val Ser Leu Gln Pro 
        355                 360                 365             


Ala Gln Met His Arg Phe Trp Arg Gly Leu Pro Leu His Leu Asp Ser 
    370                 375                 380                 


Val Asp Ala Val Tyr Glu Arg Thr Ser Asp His Lys Ile Val Phe Phe 
385                 390                 395                 400 


Lys Gly Asp Arg Tyr Trp Val Phe Lys Asp Asn Asn Val Glu Glu Gly 
                405                 410                 415     


Tyr Pro Arg Pro Val Ser Asp Phe Ser Leu Pro Pro Gly Gly Ile Asp 
            420                 425                 430         


Ala Ala Phe Ser Trp Ala His Asn Asp Arg Thr Tyr Phe Phe Lys Asp 
        435                 440                 445             


Gln Leu Tyr Trp Arg Tyr Asp Asp His Thr Arg His Met Asp Pro Gly 
    450                 455                 460                 


Tyr Pro Ala Gln Ser Pro Leu Trp Arg Gly Val Pro Ser Thr Leu Asp 
465                 470                 475                 480 


Asp Ala Met Arg Trp Ser Asp Gly Ala Ser Tyr Phe Phe Arg Gly Gln 
                485                 490                 495     


Glu Tyr Trp Lys Val Leu Asp Gly Glu Leu Glu Val Ala Pro Gly Tyr 
            500                 505                 510         


Pro Gln Ser Thr Ala Arg Asp Trp Leu Val Cys Gly Asp Ser Gln Ala 
        515                 520                 525             


Asp Gly Ser Val Ala Ala Gly Val Asp Ala Ala Glu Gly Pro Arg Ala 
    530                 535                 540                 


Pro Pro Gly Gln His Asp Gln Ser Arg Ser Glu Asp Gly Tyr Glu Val 
545                 550                 555                 560 


Cys Ser Cys Thr Ser Gly Ala Ser Ser Pro Pro Gly Ala Pro Gly Pro 
                565                 570                 575     


Leu Val Ala Ala Thr Met Leu Leu Leu Leu Pro Pro Leu Ser Pro Gly 
            580                 585                 590         


Ala Leu Trp Thr Ala Ala Gln Ala Leu Thr Leu 
        595                 600             


<210>  31
<211>  645
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Pro Arg Ser Arg Gly Gly Arg Ala Ala Pro Gly Pro Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Pro Gly Gln Ala Pro Arg Trp Ser Arg Trp Arg Val Pro 
            20                  25                  30          


Gly Arg Leu Leu Leu Leu Leu Leu Pro Ala Leu Cys Cys Leu Pro Gly 
        35                  40                  45              


Ala Ala Arg Ala Ala Ala Ala Ala Ala Gly Ala Gly Asn Arg Ala Ala 
    50                  55                  60                  


Val Ala Val Ala Val Ala Arg Ala Asp Glu Ala Glu Ala Pro Phe Ala 
65                  70                  75                  80  


Gly Gln Asn Trp Leu Lys Ser Tyr Gly Tyr Leu Leu Pro Tyr Asp Ser 
                85                  90                  95      


Arg Ala Ser Ala Leu His Ser Ala Lys Ala Leu Gln Ser Ala Val Ser 
            100                 105                 110         


Thr Met Gln Gln Phe Tyr Gly Ile Pro Val Thr Gly Val Leu Asp Gln 
        115                 120                 125             


Thr Thr Ile Glu Trp Met Lys Lys Pro Arg Cys Gly Val Pro Asp His 
    130                 135                 140                 


Pro His Leu Ser Arg Arg Arg Arg Asn Lys Arg Tyr Ala Leu Thr Gly 
145                 150                 155                 160 


Gln Lys Trp Arg Gln Lys His Ile Thr Tyr Ser Ile His Asn Tyr Thr 
                165                 170                 175     


Pro Lys Val Gly Glu Leu Asp Thr Arg Lys Ala Ile Arg Gln Ala Phe 
            180                 185                 190         


Asp Val Trp Gln Lys Val Thr Pro Leu Thr Phe Glu Glu Val Pro Tyr 
        195                 200                 205             


His Glu Ile Lys Ser Asp Arg Lys Glu Ala Asp Ile Met Ile Phe Phe 
    210                 215                 220                 


Ala Ser Gly Phe His Gly Asp Ser Ser Pro Phe Asp Gly Glu Gly Gly 
225                 230                 235                 240 


Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Gly Ile Gly Gly Asp Thr 
                245                 250                 255     


His Phe Asp Ser Asp Glu Pro Trp Thr Leu Gly Asn Ala Asn His Asp 
            260                 265                 270         


Gly Asn Asp Leu Phe Leu Val Ala Val His Glu Leu Gly His Ala Leu 
        275                 280                 285             


Gly Leu Glu His Ser Ser Asp Pro Ser Ala Ile Met Ala Pro Phe Tyr 
    290                 295                 300                 


Gln Tyr Met Glu Thr His Asn Phe Lys Leu Pro Gln Asp Asp Leu Gln 
305                 310                 315                 320 


Gly Ile Gln Lys Ile Tyr Gly Pro Pro Ala Glu Pro Leu Glu Pro Thr 
                325                 330                 335     


Arg Pro Leu Pro Thr Leu Pro Val Arg Arg Ile His Ser Pro Ser Glu 
            340                 345                 350         


Arg Lys His Glu Arg Gln Pro Arg Pro Pro Arg Pro Pro Leu Gly Asp 
        355                 360                 365             


Arg Pro Ser Thr Pro Gly Thr Lys Pro Asn Ile Cys Asp Gly Asn Phe 
    370                 375                 380                 


Asn Thr Val Ala Leu Phe Arg Gly Glu Met Phe Val Phe Lys Asp Arg 
385                 390                 395                 400 


Trp Phe Trp Arg Leu Arg Asn Asn Arg Val Gln Glu Gly Tyr Pro Met 
                405                 410                 415     


Gln Ile Glu Gln Phe Trp Lys Gly Leu Pro Ala Arg Ile Asp Ala Ala 
            420                 425                 430         


Tyr Glu Arg Ala Asp Gly Arg Phe Val Phe Phe Lys Gly Asp Lys Tyr 
        435                 440                 445             


Trp Val Phe Lys Glu Val Thr Val Glu Pro Gly Tyr Pro His Ser Leu 
    450                 455                 460                 


Gly Glu Leu Gly Ser Cys Leu Pro Arg Glu Gly Ile Asp Thr Ala Leu 
465                 470                 475                 480 


Arg Trp Glu Pro Val Gly Lys Thr Tyr Phe Phe Lys Gly Glu Arg Tyr 
                485                 490                 495     


Trp Arg Tyr Ser Glu Glu Arg Arg Ala Thr Asp Pro Gly Tyr Pro Lys 
            500                 505                 510         


Pro Ile Thr Val Trp Lys Gly Ile Pro Gln Ala Pro Gln Gly Ala Phe 
        515                 520                 525             


Ile Ser Lys Glu Gly Tyr Tyr Thr Tyr Phe Tyr Lys Gly Arg Asp Tyr 
    530                 535                 540                 


Trp Lys Phe Asp Asn Gln Lys Leu Ser Val Glu Pro Gly Tyr Pro Arg 
545                 550                 555                 560 


Asn Ile Leu Arg Asp Trp Met Gly Cys Asn Gln Lys Glu Val Glu Arg 
                565                 570                 575     


Arg Lys Glu Arg Arg Leu Pro Gln Asp Asp Val Asp Ile Met Val Thr 
            580                 585                 590         


Ile Asn Asp Val Pro Gly Ser Val Asn Ala Val Ala Val Val Ile Pro 
        595                 600                 605             


Cys Ile Leu Ser Leu Cys Ile Leu Val Leu Val Tyr Thr Ile Phe Gln 
    610                 615                 620                 


Phe Lys Asn Lys Thr Gly Pro Gln Pro Val Thr Tyr Tyr Lys Arg Pro 
625                 630                 635                 640 


Val Gln Glu Trp Val 
                645 


<210>  32
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Arg Leu Arg Leu Arg Leu Leu Ala Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Pro Pro Ala Arg Ala Pro Lys Pro Ser Ala Gln Asp Val Ser Leu Gly 
            20                  25                  30          


Val Asp Trp Leu Thr Arg Tyr Gly Tyr Leu Pro Pro Pro His Pro Ala 
        35                  40                  45              


Gln Ala Gln Leu Gln Ser Pro Glu Lys Leu Arg Asp Ala Ile Lys Val 
    50                  55                  60                  


Met Gln Arg Phe Ala Gly Leu Pro Glu Thr Gly Arg Met Asp Pro Gly 
65                  70                  75                  80  


Thr Val Ala Thr Met Arg Lys Pro Arg Cys Ser Leu Pro Asp Val Leu 
                85                  90                  95      


Gly Val Ala Gly Leu Val Arg Arg Arg Arg Arg Tyr Ala Leu Ser Gly 
            100                 105                 110         


Ser Val Trp Lys Lys Arg Thr Leu Thr Trp Arg Val Arg Ser Phe Pro 
        115                 120                 125             


Gln Ser Ser Gln Leu Ser Gln Glu Thr Val Arg Val Leu Met Ser Tyr 
    130                 135                 140                 


Ala Leu Met Ala Trp Gly Met Glu Ser Gly Leu Thr Phe His Glu Val 
145                 150                 155                 160 


Asp Ser Pro Gln Gly Gln Glu Pro Asp Ile Leu Ile Asp Phe Ala Arg 
                165                 170                 175     


Ala Phe His Gln Asp Ser Tyr Pro Phe Asp Gly Leu Gly Gly Thr Leu 
            180                 185                 190         


Ala His Ala Phe Phe Pro Gly Glu His Pro Ile Ser Gly Asp Thr His 
        195                 200                 205             


Phe Asp Asp Glu Glu Thr Trp Thr Phe Gly Ser Lys Asp Gly Glu Gly 
    210                 215                 220                 


Thr Asp Leu Phe Ala Val Ala Val His Glu Phe Gly His Ala Leu Gly 
225                 230                 235                 240 


Leu Gly His Ser Ser Ala Pro Asn Ser Ile Met Arg Pro Phe Tyr Gln 
                245                 250                 255     


Gly Pro Val Gly Asp Pro Asp Lys Tyr Arg Leu Ser Gln Asp Asp Arg 
            260                 265                 270         


Asp Gly Leu Gln Gln Leu Tyr Gly Lys Ala Pro Gln Thr Pro Tyr Asp 
        275                 280                 285             


Lys Pro Thr Arg Lys Pro Leu Ala Pro Pro Pro Gln Pro Pro Ala Ser 
    290                 295                 300                 


Pro Thr His Ser Pro Ser Phe Pro Ile Pro Asp Arg Cys Glu Gly Asn 
305                 310                 315                 320 


Phe Asp Ala Ile Ala Asn Ile Arg Gly Glu Thr Phe Phe Phe Lys Gly 
                325                 330                 335     


Pro Trp Phe Trp Arg Leu Gln Pro Ser Gly Gln Leu Val Ser Pro Arg 
            340                 345                 350         


Pro Ala Arg Leu His Arg Phe Trp Glu Gly Leu Pro Ala Gln Val Arg 
        355                 360                 365             


Val Val Gln Ala Ala Tyr Ala Arg His Arg Asp Gly Arg Ile Leu Leu 
    370                 375                 380                 


Phe Ser Gly Pro Gln Phe Trp Val Phe Gln Asp Arg Gln Leu Glu Gly 
385                 390                 395                 400 


Gly Ala Arg Pro Leu Thr Glu Leu Gly Leu Pro Pro Gly Glu Glu Val 
                405                 410                 415     


Asp Ala Val Phe Ser Trp Pro Gln Asn Gly Lys Thr Tyr Leu Val Arg 
            420                 425                 430         


Gly Arg Gln Tyr Trp Arg Tyr Asp Glu Ala Ala Ala Arg Pro Asp Pro 
        435                 440                 445             


Gly Tyr Pro Arg Asp Leu Ser Leu Trp Glu Gly Ala Pro Pro Ser Pro 
    450                 455                 460                 


Asp Asp Val Thr Val Ser Asn Ala Gly Asp Thr Tyr Phe Phe Lys Gly 
465                 470                 475                 480 


Ala His Tyr Trp Arg Phe Pro Lys Asn Ser Ile Lys Thr Glu Pro Asp 
                485                 490                 495     


Ala Pro Gln Pro Met Gly Pro Asn Trp Leu Asp Cys Pro Ala Pro Ser 
            500                 505                 510         


Ser Gly Pro Arg Ala Pro Arg Pro Pro Lys Ala Thr Pro Val Ser Glu 
        515                 520                 525             


Thr Cys Asp Cys Gln Cys Glu Leu Asn Gln Ala Ala Gly Arg Trp Pro 
    530                 535                 540                 


Ala Pro Ile Pro Leu Leu Leu Leu Pro Leu Leu Val Gly Gly Val Ala 
545                 550                 555                 560 


Ser Arg 
        


<210>  33
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Gln Leu Val Ile Leu Arg Val Thr Ile Phe Leu Pro Trp Cys Phe 
1               5                   10                  15      


Ala Val Pro Val Pro Pro Ala Ala Asp His Lys Gly Trp Asp Phe Val 
            20                  25                  30          


Glu Gly Tyr Phe His Gln Phe Phe Leu Thr Lys Lys Glu Ser Pro Leu 
        35                  40                  45              


Leu Thr Gln Glu Thr Gln Thr Gln Leu Leu Gln Gln Phe His Arg Asn 
    50                  55                  60                  


Gly Thr Asp Leu Leu Asp Met Gln Met His Ala Leu Leu His Gln Pro 
65                  70                  75                  80  


His Cys Gly Val Pro Asp Gly Ser Asp Thr Ser Ile Ser Pro Gly Arg 
                85                  90                  95      


Cys Lys Trp Asn Lys His Thr Leu Thr Tyr Arg Ile Ile Asn Tyr Pro 
            100                 105                 110         


His Asp Met Lys Pro Ser Ala Val Lys Asp Ser Ile Tyr Asn Ala Val 
        115                 120                 125             


Ser Ile Trp Ser Asn Val Thr Pro Leu Ile Phe Gln Gln Val Gln Asn 
    130                 135                 140                 


Gly Asp Ala Asp Ile Lys Val Ser Phe Trp Gln Trp Ala His Glu Asp 
145                 150                 155                 160 


Gly Trp Pro Phe Asp Gly Pro Gly Gly Ile Leu Gly His Ala Phe Leu 
                165                 170                 175     


Pro Asn Ser Gly Asn Pro Gly Val Val His Phe Asp Lys Asn Glu His 
            180                 185                 190         


Trp Ser Ala Ser Asp Thr Gly Tyr Asn Leu Phe Leu Val Ala Thr His 
        195                 200                 205             


Glu Ile Gly His Ser Leu Gly Leu Gln His Ser Gly Asn Gln Ser Ser 
    210                 215                 220                 


Ile Met Tyr Pro Thr Tyr Trp Tyr His Asp Pro Arg Thr Phe Gln Leu 
225                 230                 235                 240 


Ser Ala Asp Asp Ile Gln Arg Ile Gln His Leu Tyr Gly Glu Lys Cys 
                245                 250                 255     


Ser Ser Asp Ile Pro 
            260     


<210>  34
<211>  967
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Gln Arg Ala Val Pro Glu Gly Phe Gly Arg Arg Lys Leu Gly Ser 
1               5                   10                  15      


Asp Met Gly Asn Ala Glu Arg Ala Pro Gly Ser Arg Ser Phe Gly Pro 
            20                  25                  30          


Val Pro Thr Leu Leu Leu Leu Ala Ala Ala Leu Leu Ala Val Ser Asp 
        35                  40                  45              


Ala Leu Gly Arg Pro Ser Glu Glu Asp Glu Glu Leu Val Val Pro Glu 
    50                  55                  60                  


Leu Glu Arg Ala Pro Gly His Gly Thr Thr Arg Leu Arg Leu His Ala 
65                  70                  75                  80  


Phe Asp Gln Gln Leu Asp Leu Glu Leu Arg Pro Asp Ser Ser Phe Leu 
                85                  90                  95      


Ala Pro Gly Phe Thr Leu Gln Asn Val Gly Arg Lys Ser Gly Ser Glu 
            100                 105                 110         


Thr Pro Leu Pro Glu Thr Asp Leu Ala His Cys Phe Tyr Ser Gly Thr 
        115                 120                 125             


Val Asn Gly Asp Pro Ser Ser Ala Ala Ala Leu Ser Leu Cys Glu Gly 
    130                 135                 140                 


Val Arg Gly Ala Phe Tyr Leu Leu Gly Glu Ala Tyr Phe Ile Gln Pro 
145                 150                 155                 160 


Leu Pro Ala Ala Ser Glu Arg Leu Ala Thr Ala Ala Pro Gly Glu Lys 
                165                 170                 175     


Pro Pro Ala Pro Leu Gln Phe His Leu Leu Arg Arg Asn Arg Gln Gly 
            180                 185                 190         


Asp Val Gly Gly Thr Cys Gly Val Val Asp Asp Glu Pro Arg Pro Thr 
        195                 200                 205             


Gly Lys Ala Glu Thr Glu Asp Glu Asp Glu Gly Thr Glu Gly Glu Asp 
    210                 215                 220                 


Glu Gly Ala Gln Trp Ser Pro Gln Asp Pro Ala Leu Gln Gly Val Gly 
225                 230                 235                 240 


Gln Pro Thr Gly Thr Gly Ser Ile Arg Lys Lys Arg Phe Val Ser Ser 
                245                 250                 255     


His Arg Tyr Val Glu Thr Met Leu Val Ala Asp Gln Ser Met Ala Glu 
            260                 265                 270         


Phe His Gly Ser Gly Leu Lys His Tyr Leu Leu Thr Leu Phe Ser Val 
        275                 280                 285             


Ala Ala Arg Leu Tyr Lys His Pro Ser Ile Arg Asn Ser Val Ser Leu 
    290                 295                 300                 


Val Val Val Lys Ile Leu Val Ile His Asp Glu Gln Lys Gly Pro Glu 
305                 310                 315                 320 


Val Thr Ser Asn Ala Ala Leu Thr Leu Arg Asn Phe Cys Asn Trp Gln 
                325                 330                 335     


Lys Gln His Asn Pro Pro Ser Asp Arg Asp Ala Glu His Tyr Asp Thr 
            340                 345                 350         


Ala Ile Leu Phe Thr Arg Gln Asp Leu Cys Gly Ser Gln Thr Cys Asp 
        355                 360                 365             


Thr Leu Gly Met Ala Asp Val Gly Thr Val Cys Asp Pro Ser Arg Ser 
    370                 375                 380                 


Cys Ser Val Ile Glu Asp Asp Gly Leu Gln Ala Ala Phe Thr Thr Ala 
385                 390                 395                 400 


His Glu Leu Gly His Val Phe Asn Met Pro His Asp Asp Ala Lys Gln 
                405                 410                 415     


Cys Ala Ser Leu Asn Gly Val Asn Gln Asp Ser His Met Met Ala Ser 
            420                 425                 430         


Met Leu Ser Asn Leu Asp His Ser Gln Pro Trp Ser Pro Cys Ser Ala 
        435                 440                 445             


Tyr Met Ile Thr Ser Phe Leu Asp Asn Gly His Gly Glu Cys Leu Met 
    450                 455                 460                 


Asp Lys Pro Gln Asn Pro Ile Gln Leu Pro Gly Asp Leu Pro Gly Thr 
465                 470                 475                 480 


Ser Tyr Asp Ala Asn Arg Gln Cys Gln Phe Thr Phe Gly Glu Asp Ser 
                485                 490                 495     


Lys His Cys Pro Asp Ala Ala Ser Thr Cys Ser Thr Leu Trp Cys Thr 
            500                 505                 510         


Gly Thr Ser Gly Gly Val Leu Val Cys Gln Thr Lys His Phe Pro Trp 
        515                 520                 525             


Ala Asp Gly Thr Ser Cys Gly Glu Gly Lys Trp Cys Ile Asn Gly Lys 
    530                 535                 540                 


Cys Val Asn Lys Thr Asp Arg Lys His Phe Asp Thr Pro Phe His Gly 
545                 550                 555                 560 


Ser Trp Gly Met Trp Gly Pro Trp Gly Asp Cys Ser Arg Thr Cys Gly 
                565                 570                 575     


Gly Gly Val Gln Tyr Thr Met Arg Glu Cys Asp Asn Pro Val Pro Lys 
            580                 585                 590         


Asn Gly Gly Lys Tyr Cys Glu Gly Lys Arg Val Arg Tyr Arg Ser Cys 
        595                 600                 605             


Asn Leu Glu Asp Cys Pro Asp Asn Asn Gly Lys Thr Phe Arg Glu Glu 
    610                 615                 620                 


Gln Cys Glu Ala His Asn Glu Phe Ser Lys Ala Ser Phe Gly Ser Gly 
625                 630                 635                 640 


Pro Ala Val Glu Trp Ile Pro Lys Tyr Ala Gly Val Ser Pro Lys Asp 
                645                 650                 655     


Arg Cys Lys Leu Ile Cys Gln Ala Lys Gly Ile Gly Tyr Phe Phe Val 
            660                 665                 670         


Leu Gln Pro Lys Val Val Asp Gly Thr Pro Cys Ser Pro Asp Ser Thr 
        675                 680                 685             


Ser Val Cys Val Gln Gly Gln Cys Val Lys Ala Gly Cys Asp Arg Ile 
    690                 695                 700                 


Ile Asp Ser Lys Lys Lys Phe Asp Lys Cys Gly Val Cys Gly Gly Asn 
705                 710                 715                 720 


Gly Ser Thr Cys Lys Lys Ile Ser Gly Ser Val Thr Ser Ala Lys Pro 
                725                 730                 735     


Gly Tyr His Asp Ile Ile Thr Ile Pro Thr Gly Ala Thr Asn Ile Glu 
            740                 745                 750         


Val Lys Gln Arg Asn Gln Arg Gly Ser Arg Asn Asn Gly Ser Phe Leu 
        755                 760                 765             


Ala Ile Lys Ala Ala Asp Gly Thr Tyr Ile Leu Asn Gly Asp Tyr Thr 
    770                 775                 780                 


Leu Ser Thr Leu Glu Gln Asp Ile Met Tyr Lys Gly Val Val Leu Arg 
785                 790                 795                 800 


Tyr Ser Gly Ser Ser Ala Ala Leu Glu Arg Ile Arg Ser Phe Ser Pro 
                805                 810                 815     


Leu Lys Glu Pro Leu Thr Ile Gln Val Leu Thr Val Gly Asn Ala Leu 
            820                 825                 830         


Arg Pro Lys Ile Lys Tyr Thr Tyr Phe Val Lys Lys Lys Lys Glu Ser 
        835                 840                 845             


Phe Asn Ala Ile Pro Thr Phe Ser Ala Trp Val Ile Glu Glu Trp Gly 
    850                 855                 860                 


Glu Cys Ser Lys Ser Cys Glu Leu Gly Trp Gln Arg Arg Leu Val Glu 
865                 870                 875                 880 


Cys Arg Asp Ile Asn Gly Gln Pro Ala Ser Glu Cys Ala Lys Glu Val 
                885                 890                 895     


Lys Pro Ala Ser Thr Arg Pro Cys Ala Asp His Pro Cys Pro Gln Trp 
            900                 905                 910         


Gln Leu Gly Glu Trp Ser Ser Cys Ser Lys Thr Cys Gly Lys Gly Tyr 
        915                 920                 925             


Lys Lys Arg Ser Leu Lys Cys Leu Ser His Asp Gly Gly Val Leu Ser 
    930                 935                 940                 


His Glu Ser Cys Asp Pro Leu Lys Lys Pro Lys His Phe Ile Asp Phe 
945                 950                 955                 960 


Cys Thr Met Ala Glu Cys Ser 
                965         


<210>  35
<211>  837
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ser Gln Thr Gly Ser His Pro Gly Arg Gly Leu Ala Gly Arg Trp 
1               5                   10                  15      


Leu Trp Gly Ala Gln Pro Cys Leu Leu Leu Pro Ile Val Pro Leu Ser 
            20                  25                  30          


Trp Leu Val Trp Leu Leu Leu Leu Leu Leu Ala Ser Leu Leu Pro Ser 
        35                  40                  45              


Ala Arg Leu Ala Ser Pro Leu Pro Arg Glu Glu Glu Ile Val Phe Pro 
    50                  55                  60                  


Glu Lys Leu Asn Gly Ser Val Leu Pro Gly Ser Gly Ala Pro Ala Arg 
65                  70                  75                  80  


Leu Leu Cys Arg Leu Gln Ala Phe Gly Glu Thr Leu Leu Leu Glu Leu 
                85                  90                  95      


Glu Gln Asp Ser Gly Val Gln Val Glu Gly Leu Thr Val Gln Tyr Leu 
            100                 105                 110         


Gly Gln Ala Pro Glu Leu Leu Gly Gly Ala Glu Pro Gly Thr Tyr Leu 
        115                 120                 125             


Thr Gly Thr Ile Asn Gly Asp Pro Glu Ser Val Ala Ser Leu His Trp 
    130                 135                 140                 


Asp Gly Gly Ala Leu Leu Gly Val Leu Gln Tyr Arg Gly Ala Glu Leu 
145                 150                 155                 160 


His Leu Gln Pro Leu Glu Gly Gly Thr Pro Asn Ser Ala Gly Gly Pro 
                165                 170                 175     


Gly Ala His Ile Leu Arg Arg Lys Ser Pro Ala Ser Gly Gln Gly Pro 
            180                 185                 190         


Met Cys Asn Val Lys Ala Pro Leu Gly Ser Pro Ser Pro Arg Pro Arg 
        195                 200                 205             


Arg Ala Lys Arg Phe Ala Ser Leu Ser Arg Phe Val Glu Thr Leu Val 
    210                 215                 220                 


Val Ala Asp Asp Lys Met Ala Ala Phe His Gly Ala Gly Leu Lys Arg 
225                 230                 235                 240 


Tyr Leu Leu Thr Val Met Ala Ala Ala Ala Lys Ala Phe Lys His Pro 
                245                 250                 255     


Ser Ile Arg Asn Pro Val Ser Leu Val Val Thr Arg Leu Val Ile Leu 
            260                 265                 270         


Gly Ser Gly Glu Glu Gly Pro Gln Val Gly Pro Ser Ala Ala Gln Thr 
        275                 280                 285             


Leu Arg Ser Phe Cys Ala Trp Gln Arg Gly Leu Asn Thr Pro Glu Asp 
    290                 295                 300                 


Ser Asp Pro Asp His Phe Asp Thr Ala Ile Leu Phe Thr Arg Gln Asp 
305                 310                 315                 320 


Leu Cys Gly Val Ser Thr Cys Asp Thr Leu Gly Met Ala Asp Val Gly 
                325                 330                 335     


Thr Val Cys Asp Pro Ala Arg Ser Cys Ala Ile Val Glu Asp Asp Gly 
            340                 345                 350         


Leu Gln Ser Ala Phe Thr Ala Ala His Glu Leu Gly His Val Phe Asn 
        355                 360                 365             


Met Leu His Asp Asn Ser Lys Pro Cys Ile Ser Leu Asn Gly Pro Leu 
    370                 375                 380                 


Ser Thr Ser Arg His Val Met Ala Pro Val Met Ala His Val Asp Pro 
385                 390                 395                 400 


Glu Glu Pro Trp Ser Pro Cys Ser Ala Arg Phe Ile Thr Asp Phe Leu 
                405                 410                 415     


Asp Asn Gly Tyr Gly His Cys Leu Leu Asp Lys Pro Glu Ala Pro Leu 
            420                 425                 430         


His Leu Pro Val Thr Phe Pro Gly Lys Asp Tyr Asp Ala Asp Arg Gln 
        435                 440                 445             


Cys Gln Leu Thr Phe Gly Pro Asp Ser Arg His Cys Pro Gln Leu Pro 
    450                 455                 460                 


Pro Pro Cys Ala Ala Leu Trp Cys Ser Gly His Leu Asn Gly His Ala 
465                 470                 475                 480 


Met Cys Gln Thr Lys His Ser Pro Trp Ala Asp Gly Thr Pro Cys Gly 
                485                 490                 495     


Pro Ala Gln Ala Cys Met Gly Gly Arg Cys Leu His Met Asp Gln Leu 
            500                 505                 510         


Gln Asp Phe Asn Ile Pro Gln Ala Gly Gly Trp Gly Pro Trp Gly Pro 
        515                 520                 525             


Trp Gly Asp Cys Ser Arg Thr Cys Gly Gly Gly Val Gln Phe Ser Ser 
    530                 535                 540                 


Arg Asp Cys Thr Arg Pro Val Pro Arg Asn Gly Gly Lys Tyr Cys Glu 
545                 550                 555                 560 


Gly Arg Arg Thr Arg Phe Arg Ser Cys Asn Thr Glu Asp Cys Pro Thr 
                565                 570                 575     


Gly Ser Ala Leu Thr Phe Arg Glu Glu Gln Cys Ala Ala Tyr Asn His 
            580                 585                 590         


Arg Thr Asp Leu Phe Lys Ser Phe Pro Gly Pro Met Asp Trp Val Pro 
        595                 600                 605             


Arg Tyr Thr Gly Val Ala Pro Gln Asp Gln Cys Lys Leu Thr Cys Gln 
    610                 615                 620                 


Ala Gln Ala Leu Gly Tyr Tyr Tyr Val Leu Glu Pro Arg Val Val Asp 
625                 630                 635                 640 


Gly Thr Pro Cys Ser Pro Asp Ser Ser Ser Val Cys Val Gln Gly Arg 
                645                 650                 655     


Cys Ile His Ala Gly Cys Asp Arg Ile Ile Gly Ser Lys Lys Lys Phe 
            660                 665                 670         


Asp Lys Cys Met Val Cys Gly Gly Asp Gly Ser Gly Cys Ser Lys Gln 
        675                 680                 685             


Ser Gly Ser Phe Arg Lys Phe Arg Tyr Gly Tyr Asn Asn Val Val Thr 
    690                 695                 700                 


Ile Pro Ala Gly Ala Thr His Ile Leu Val Arg Gln Gln Gly Asn Pro 
705                 710                 715                 720 


Gly His Arg Ser Ile Tyr Leu Ala Leu Lys Leu Pro Asp Gly Ser Tyr 
                725                 730                 735     


Ala Leu Asn Gly Glu Tyr Thr Leu Met Pro Ser Pro Thr Asp Val Val 
            740                 745                 750         


Leu Pro Gly Ala Val Ser Leu Arg Tyr Ser Gly Ala Thr Ala Ala Ser 
        755                 760                 765             


Glu Thr Leu Ser Gly His Gly Pro Leu Ala Gln Pro Leu Thr Leu Gln 
    770                 775                 780                 


Val Leu Val Ala Gly Asn Pro Gln Asp Thr Arg Leu Arg Tyr Ser Phe 
785                 790                 795                 800 


Phe Val Pro Arg Pro Thr Pro Ser Thr Pro Arg Pro Thr Pro Gln Asp 
                805                 810                 815     


Trp Leu His Arg Arg Ala Gln Ile Leu Glu Ile Leu Arg Arg Arg Pro 
            820                 825                 830         


Trp Ala Gly Arg Lys 
        835         


<210>  36
<211>  930
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Leu Leu Gly Trp Ala Ser Leu Leu Leu Cys Ala Phe Arg Leu Pro 
1               5                   10                  15      


Leu Ala Ala Val Gly Pro Ala Ala Thr Pro Ala Gln Asp Lys Ala Gly 
            20                  25                  30          


Gln Pro Pro Thr Ala Ala Ala Ala Ala Gln Pro Arg Arg Arg Gln Gly 
        35                  40                  45              


Glu Glu Val Gln Glu Arg Ala Glu Pro Pro Gly His Pro His Pro Leu 
    50                  55                  60                  


Ala Gln Arg Arg Arg Ser Lys Gly Leu Val Gln Asn Ile Asp Gln Leu 
65                  70                  75                  80  


Tyr Ser Gly Gly Gly Lys Val Gly Tyr Leu Val Tyr Ala Gly Gly Arg 
                85                  90                  95      


Arg Phe Leu Leu Asp Leu Glu Arg Asp Gly Ser Val Gly Ile Ala Gly 
            100                 105                 110         


Phe Val Pro Ala Gly Gly Gly Thr Ser Ala Pro Trp Arg His Arg Ser 
        115                 120                 125             


His Cys Phe Tyr Arg Gly Thr Val Asp Gly Ser Pro Arg Ser Leu Ala 
    130                 135                 140                 


Val Phe Asp Leu Cys Gly Gly Leu Asp Gly Phe Phe Ala Val Lys His 
145                 150                 155                 160 


Ala Arg Tyr Thr Leu Lys Pro Leu Leu Arg Gly Pro Trp Ala Glu Glu 
                165                 170                 175     


Glu Lys Gly Arg Val Tyr Gly Asp Gly Ser Ala Arg Ile Leu His Val 
            180                 185                 190         


Tyr Thr Arg Glu Gly Phe Ser Phe Glu Ala Leu Pro Pro Arg Ala Ser 
        195                 200                 205             


Cys Glu Thr Pro Ala Ser Thr Pro Glu Ala His Glu His Ala Pro Ala 
    210                 215                 220                 


His Ser Asn Pro Ser Gly Arg Ala Ala Leu Ala Ser Gln Leu Leu Asp 
225                 230                 235                 240 


Gln Ser Ala Leu Ser Pro Ala Gly Gly Ser Gly Pro Gln Thr Trp Trp 
                245                 250                 255     


Arg Arg Arg Arg Arg Ser Ile Ser Arg Ala Arg Gln Val Glu Leu Leu 
            260                 265                 270         


Leu Val Ala Asp Ala Ser Met Ala Arg Leu Tyr Gly Arg Gly Leu Gln 
        275                 280                 285             


His Tyr Leu Leu Thr Leu Ala Ser Ile Ala Asn Arg Leu Tyr Ser His 
    290                 295                 300                 


Ala Ser Ile Glu Asn His Ile Arg Leu Ala Val Val Lys Val Val Val 
305                 310                 315                 320 


Leu Gly Asp Lys Asp Lys Ser Leu Glu Val Ser Lys Asn Ala Ala Thr 
                325                 330                 335     


Thr Leu Lys Asn Phe Cys Lys Trp Gln His Gln His Asn Gln Leu Gly 
            340                 345                 350         


Asp Asp His Glu Glu His Tyr Asp Ala Ala Ile Leu Phe Thr Arg Glu 
        355                 360                 365             


Asp Leu Cys Gly His His Ser Cys Asp Thr Leu Gly Met Ala Asp Val 
    370                 375                 380                 


Gly Thr Ile Cys Ser Pro Glu Arg Ser Cys Ala Val Ile Glu Asp Asp 
385                 390                 395                 400 


Gly Leu His Ala Ala Phe Thr Val Ala His Glu Ile Gly His Leu Leu 
                405                 410                 415     


Gly Leu Ser His Asp Asp Ser Lys Phe Cys Glu Glu Thr Phe Gly Ser 
            420                 425                 430         


Thr Glu Asp Lys Arg Leu Met Ser Ser Ile Leu Thr Ser Ile Asp Ala 
        435                 440                 445             


Ser Lys Pro Trp Ser Lys Cys Thr Ser Ala Thr Ile Thr Glu Phe Leu 
    450                 455                 460                 


Asp Asp Gly His Gly Asn Cys Leu Leu Asp Leu Pro Arg Lys Gln Ile 
465                 470                 475                 480 


Leu Gly Pro Glu Glu Leu Pro Gly Gln Thr Tyr Asp Ala Thr Gln Gln 
                485                 490                 495     


Cys Asn Leu Thr Phe Gly Pro Glu Tyr Ser Val Cys Pro Gly Met Asp 
            500                 505                 510         


Val Cys Ala Arg Leu Trp Cys Ala Val Val Arg Gln Gly Gln Met Val 
        515                 520                 525             


Cys Leu Thr Lys Lys Leu Pro Ala Val Glu Gly Thr Pro Cys Gly Lys 
    530                 535                 540                 


Gly Arg Ile Cys Leu Gln Gly Lys Cys Val Asp Lys Thr Lys Lys Lys 
545                 550                 555                 560 


Tyr Tyr Ser Thr Ser Ser His Gly Asn Trp Gly Ser Trp Gly Ser Trp 
                565                 570                 575     


Gly Gln Cys Ser Arg Ser Cys Gly Gly Gly Val Gln Phe Ala Tyr Arg 
            580                 585                 590         


His Cys Asn Asn Pro Ala Pro Arg Asn Asn Gly Arg Tyr Cys Thr Gly 
        595                 600                 605             


Lys Arg Ala Ile Tyr Arg Ser Cys Ser Leu Met Pro Cys Pro Pro Asn 
    610                 615                 620                 


Gly Lys Ser Phe Arg His Glu Gln Cys Glu Ala Lys Asn Gly Tyr Gln 
625                 630                 635                 640 


Ser Asp Ala Lys Gly Val Lys Thr Phe Val Glu Trp Val Pro Lys Tyr 
                645                 650                 655     


Ala Gly Val Leu Pro Ala Asp Val Cys Lys Leu Thr Cys Arg Ala Lys 
            660                 665                 670         


Gly Thr Gly Tyr Tyr Val Val Phe Ser Pro Lys Val Thr Asp Gly Thr 
        675                 680                 685             


Glu Cys Arg Leu Tyr Ser Asn Ser Val Cys Val Arg Gly Lys Cys Val 
    690                 695                 700                 


Arg Thr Gly Cys Asp Gly Ile Ile Gly Ser Lys Leu Gln Tyr Asp Lys 
705                 710                 715                 720 


Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys Thr Lys Ile Val Gly 
                725                 730                 735     


Thr Phe Asn Lys Lys Ser Lys Gly Tyr Thr Asp Val Val Arg Ile Pro 
            740                 745                 750         


Glu Gly Ala Thr His Ile Lys Val Arg Gln Phe Lys Ala Lys Asp Gln 
        755                 760                 765             


Thr Arg Phe Thr Ala Tyr Leu Ala Leu Lys Lys Lys Asn Gly Glu Tyr 
    770                 775                 780                 


Leu Ile Asn Gly Lys Tyr Met Ile Ser Thr Ser Glu Thr Ile Ile Asp 
785                 790                 795                 800 


Ile Asn Gly Thr Val Met Asn Tyr Ser Gly Trp Ser His Arg Asp Asp 
                805                 810                 815     


Phe Leu His Gly Met Gly Tyr Ser Ala Thr Lys Glu Ile Leu Ile Val 
            820                 825                 830         


Gln Ile Leu Ala Thr Asp Pro Thr Lys Pro Leu Asp Val Arg Tyr Ser 
        835                 840                 845             


Phe Phe Val Pro Lys Lys Ser Thr Pro Lys Val Asn Ser Val Thr Ser 
    850                 855                 860                 


His Gly Ser Asn Lys Val Gly Ser His Thr Ser Gln Pro Gln Trp Val 
865                 870                 875                 880 


Thr Gly Pro Trp Leu Ala Cys Ser Arg Thr Cys Asp Thr Gly Trp His 
                885                 890                 895     


Thr Arg Thr Val Gln Cys Gln Asp Gly Asn Arg Lys Leu Ala Lys Gly 
            900                 905                 910         


Cys Pro Leu Ser Gln Arg Pro Ser Ala Phe Lys Gln Cys Leu Leu Lys 
        915                 920                 925             


Lys Cys 
    930 


<210>  37
<211>  889
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Leu Pro Ala Pro Ala Ala Pro Arg Trp Pro Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Leu Ala Arg Gly Ala Pro Ala Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Gln Ala Ser Glu Leu Val Val Pro Thr Arg Leu Pro Gly 
        35                  40                  45              


Ser Ala Gly Glu Leu Ala Leu His Leu Ser Ala Phe Gly Lys Gly Phe 
    50                  55                  60                  


Val Leu Arg Leu Ala Pro Asp Asp Ser Phe Leu Ala Pro Glu Phe Lys 
65                  70                  75                  80  


Ile Glu Arg Leu Gly Gly Ser Gly Arg Ala Thr Gly Gly Glu Arg Gly 
                85                  90                  95      


Leu Arg Gly Cys Phe Phe Ser Gly Thr Val Asn Gly Glu Pro Glu Ser 
            100                 105                 110         


Leu Ala Ala Val Ser Leu Cys Arg Gly Leu Ser Gly Ser Phe Leu Leu 
        115                 120                 125             


Asp Gly Glu Glu Phe Thr Ile Gln Pro Gln Gly Ala Gly Gly Ser Leu 
    130                 135                 140                 


Ala Gln Pro His Arg Leu Gln Arg Trp Gly Pro Ala Gly Ala Arg Pro 
145                 150                 155                 160 


Leu Pro Arg Gly Pro Glu Trp Glu Val Glu Thr Gly Glu Gly Gln Arg 
                165                 170                 175     


Gln Glu Arg Gly Asp His Gln Glu Asp Ser Glu Glu Glu Ser Gln Glu 
            180                 185                 190         


Glu Glu Ala Glu Gly Ala Ser Glu Pro Pro Pro Pro Leu Gly Ala Thr 
        195                 200                 205             


Ser Arg Thr Lys Arg Phe Val Ser Glu Ala Arg Phe Val Glu Thr Leu 
    210                 215                 220                 


Leu Val Ala Asp Ala Ser Met Ala Ala Phe Tyr Gly Ala Asp Leu Gln 
225                 230                 235                 240 


Asn His Ile Leu Thr Leu Met Ser Val Ala Ala Arg Ile Tyr Lys His 
                245                 250                 255     


Pro Ser Ile Lys Asn Ser Ile Asn Leu Met Val Val Lys Val Leu Ile 
            260                 265                 270         


Val Glu Asp Glu Lys Trp Gly Pro Glu Val Ser Asp Asn Gly Gly Leu 
        275                 280                 285             


Thr Leu Arg Asn Phe Cys Asn Trp Gln Arg Arg Phe Asn Gln Pro Ser 
    290                 295                 300                 


Asp Arg His Pro Glu His Tyr Asp Thr Ala Ile Leu Leu Thr Arg Gln 
305                 310                 315                 320 


Asn Phe Cys Gly Gln Glu Gly Leu Cys Asp Thr Leu Gly Val Ala Asp 
                325                 330                 335     


Ile Gly Thr Ile Cys Asp Pro Asn Lys Ser Cys Ser Val Ile Glu Asp 
            340                 345                 350         


Glu Gly Leu Gln Ala Ala His Thr Leu Ala His Glu Leu Gly His Val 
        355                 360                 365             


Leu Ser Met Pro His Asp Asp Ser Lys Pro Cys Thr Arg Leu Phe Gly 
    370                 375                 380                 


Pro Met Gly Lys His His Val Met Ala Pro Leu Phe Val His Leu Asn 
385                 390                 395                 400 


Gln Thr Leu Pro Trp Ser Pro Cys Ser Ala Met Tyr Leu Thr Glu Leu 
                405                 410                 415     


Leu Asp Gly Gly His Gly Asp Cys Leu Leu Asp Ala Pro Ala Ala Ala 
            420                 425                 430         


Leu Pro Leu Pro Thr Gly Leu Pro Gly Arg Met Ala Leu Tyr Gln Leu 
        435                 440                 445             


Asp Gln Gln Cys Arg Gln Ile Phe Gly Pro Asp Phe Arg His Cys Pro 
    450                 455                 460                 


Asn Thr Ser Ala Gln Asp Val Cys Ala Gln Leu Trp Cys His Thr Asp 
465                 470                 475                 480 


Gly Ala Glu Pro Leu Cys His Thr Lys Asn Gly Ser Leu Pro Trp Ala 
                485                 490                 495     


Asp Gly Thr Pro Cys Gly Pro Gly His Leu Cys Ser Glu Gly Ser Cys 
            500                 505                 510         


Leu Pro Glu Glu Glu Val Glu Arg Pro Lys Pro Val Ala Asp Gly Gly 
        515                 520                 525             


Trp Ala Pro Trp Gly Pro Trp Gly Glu Cys Ser Arg Thr Cys Gly Gly 
    530                 535                 540                 


Gly Val Gln Phe Ser His Arg Glu Cys Lys Asp Pro Glu Pro Gln Asn 
545                 550                 555                 560 


Gly Gly Arg Tyr Cys Leu Gly Arg Arg Ala Lys Tyr Gln Ser Cys His 
                565                 570                 575     


Thr Glu Glu Cys Pro Pro Asp Gly Lys Ser Phe Arg Glu Gln Gln Cys 
            580                 585                 590         


Glu Lys Tyr Asn Ala Tyr Asn Tyr Thr Asp Met Asp Gly Asn Leu Leu 
        595                 600                 605             


Gln Trp Val Pro Lys Tyr Ala Gly Val Ser Pro Arg Asp Arg Cys Lys 
    610                 615                 620                 


Leu Phe Cys Arg Ala Arg Gly Arg Ser Glu Phe Lys Val Phe Glu Ala 
625                 630                 635                 640 


Lys Val Ile Asp Gly Thr Leu Cys Gly Pro Glu Thr Leu Ala Ile Cys 
                645                 650                 655     


Val Arg Gly Gln Cys Val Lys Ala Gly Cys Asp His Val Val Asp Ser 
            660                 665                 670         


Pro Arg Lys Leu Asp Lys Cys Gly Val Cys Gly Gly Lys Gly Asn Ser 
        675                 680                 685             


Cys Arg Lys Val Ser Gly Ser Leu Thr Pro Thr Asn Tyr Gly Tyr Asn 
    690                 695                 700                 


Asp Ile Val Thr Ile Pro Ala Gly Ala Thr Asn Ile Asp Val Lys Gln 
705                 710                 715                 720 


Arg Ser His Pro Gly Val Gln Asn Asp Gly Asn Tyr Leu Ala Leu Lys 
                725                 730                 735     


Thr Ala Asp Gly Gln Tyr Leu Leu Asn Gly Asn Leu Ala Ile Ser Ala 
            740                 745                 750         


Ile Glu Gln Asp Ile Leu Val Lys Gly Thr Ile Leu Lys Tyr Ser Gly 
        755                 760                 765             


Ser Ile Ala Thr Leu Glu Arg Leu Gln Ser Phe Arg Pro Leu Pro Glu 
    770                 775                 780                 


Pro Leu Thr Val Gln Leu Leu Thr Val Pro Gly Glu Val Phe Pro Pro 
785                 790                 795                 800 


Lys Val Lys Tyr Thr Phe Phe Val Pro Asn Asp Val Asp Phe Ser Met 
                805                 810                 815     


Gln Ser Ser Lys Glu Arg Ala Thr Thr Asn Ile Ile Gln Pro Leu Leu 
            820                 825                 830         


His Ala Gln Trp Val Leu Gly Asp Trp Ser Glu Cys Ser Ser Thr Cys 
        835                 840                 845             


Gly Ala Gly Trp Gln Arg Arg Thr Val Glu Cys Arg Asp Pro Ser Gly 
    850                 855                 860                 


Gln Ala Ser Ala Thr Cys Asn Lys Ala Leu Lys Pro Glu Asp Ala Lys 
865                 870                 875                 880 


Pro Cys Glu Ser Gln Leu Cys Pro Leu 
                885                 


<210>  38
<211>  1935
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Gln Phe Val Ser Trp Ala Thr Leu Leu Thr Leu Leu Val Arg Asp 
1               5                   10                  15      


Leu Ala Glu Met Gly Ser Pro Asp Ala Ala Ala Ala Val Arg Lys Asp 
            20                  25                  30          


Arg Leu His Pro Arg Gln Val Lys Leu Leu Glu Thr Leu Ser Glu Tyr 
        35                  40                  45              


Glu Ile Val Ser Pro Ile Arg Val Asn Ala Leu Gly Glu Pro Phe Pro 
    50                  55                  60                  


Thr Asn Val His Phe Lys Arg Thr Arg Arg Ser Ile Asn Ser Ala Thr 
65                  70                  75                  80  


Asp Pro Trp Pro Ala Phe Ala Ser Ser Ser Ser Ser Ser Thr Ser Ser 
                85                  90                  95      


Gln Ala His Tyr Arg Leu Ser Ala Phe Gly Gln Gln Phe Leu Phe Asn 
            100                 105                 110         


Leu Thr Ala Asn Ala Gly Phe Ile Ala Pro Leu Phe Thr Val Thr Leu 
        115                 120                 125             


Leu Gly Thr Pro Gly Val Asn Gln Thr Lys Phe Tyr Ser Glu Glu Glu 
    130                 135                 140                 


Ala Glu Leu Lys His Cys Phe Tyr Lys Gly Tyr Val Asn Thr Asn Ser 
145                 150                 155                 160 


Glu His Thr Ala Val Ile Ser Leu Cys Ser Gly Met Leu Gly Thr Phe 
                165                 170                 175     


Arg Ser His Asp Gly Asp Tyr Phe Ile Glu Pro Leu Gln Ser Met Asp 
            180                 185                 190         


Glu Gln Glu Asp Glu Glu Glu Gln Asn Lys Pro His Ile Ile Tyr Arg 
        195                 200                 205             


Arg Ser Ala Pro Gln Arg Glu Pro Ser Thr Gly Arg His Ala Cys Asp 
    210                 215                 220                 


Thr Ser Glu His Lys Asn Arg His Ser Lys Asp Lys Lys Lys Thr Arg 
225                 230                 235                 240 


Ala Arg Lys Trp Gly Glu Arg Ile Asn Leu Ala Gly Asp Val Ala Ala 
                245                 250                 255     


Leu Asn Ser Gly Leu Ala Thr Glu Ala Phe Ser Ala Tyr Gly Asn Lys 
            260                 265                 270         


Thr Asp Asn Thr Arg Glu Lys Arg Thr His Arg Arg Thr Lys Arg Phe 
        275                 280                 285             


Leu Ser Tyr Pro Arg Phe Val Glu Val Leu Val Val Ala Asp Asn Arg 
    290                 295                 300                 


Met Val Ser Tyr His Gly Glu Asn Leu Gln His Tyr Ile Leu Thr Leu 
305                 310                 315                 320 


Met Ser Ile Val Ala Ser Ile Tyr Lys Asp Pro Ser Ile Gly Asn Leu 
                325                 330                 335     


Ile Asn Ile Val Ile Val Asn Leu Ile Val Ile His Asn Glu Gln Asp 
            340                 345                 350         


Gly Pro Ser Ile Ser Phe Asn Ala Gln Thr Thr Leu Lys Asn Phe Cys 
        355                 360                 365             


Gln Trp Gln His Ser Lys Asn Ser Pro Gly Gly Ile His His Asp Thr 
    370                 375                 380                 


Ala Val Leu Leu Thr Arg Gln Asp Ile Cys Arg Ala His Asp Lys Cys 
385                 390                 395                 400 


Asp Thr Leu Gly Leu Ala Glu Leu Gly Thr Ile Cys Asp Pro Tyr Arg 
                405                 410                 415     


Ser Cys Ser Ile Ser Glu Asp Ser Gly Leu Ser Thr Ala Phe Thr Ile 
            420                 425                 430         


Ala His Glu Leu Gly His Val Phe Asn Met Pro His Asp Asp Asn Asn 
        435                 440                 445             


Lys Cys Lys Glu Glu Gly Val Lys Ser Pro Gln His Val Met Ala Pro 
    450                 455                 460                 


Thr Leu Asn Phe Tyr Thr Asn Pro Trp Met Trp Ser Lys Cys Ser Arg 
465                 470                 475                 480 


Lys Tyr Ile Thr Glu Phe Leu Asp Thr Gly Tyr Gly Glu Cys Leu Leu 
                485                 490                 495     


Asn Glu Pro Glu Ser Arg Pro Tyr Pro Leu Pro Val Gln Leu Pro Gly 
            500                 505                 510         


Ile Leu Tyr Asn Val Asn Lys Gln Cys Glu Leu Ile Phe Gly Pro Gly 
        515                 520                 525             


Ser Gln Val Cys Pro Tyr Met Met Gln Cys Arg Arg Leu Trp Cys Asn 
    530                 535                 540                 


Asn Val Asn Gly Val His Lys Gly Cys Arg Thr Gln His Thr Pro Trp 
545                 550                 555                 560 


Ala Asp Gly Thr Glu Cys Glu Pro Gly Lys His Cys Lys Tyr Gly Phe 
                565                 570                 575     


Cys Val Pro Lys Glu Met Asp Val Pro Val Thr Asp Gly Ser Trp Gly 
            580                 585                 590         


Ser Trp Ser Pro Phe Gly Thr Cys Ser Arg Thr Cys Gly Gly Gly Ile 
        595                 600                 605             


Lys Thr Ala Ile Arg Glu Cys Asn Arg Pro Glu Pro Lys Asn Gly Gly 
    610                 615                 620                 


Lys Tyr Cys Val Gly Arg Arg Met Lys Phe Lys Ser Cys Asn Thr Glu 
625                 630                 635                 640 


Pro Cys Leu Lys Gln Lys Arg Asp Phe Arg Asp Glu Gln Cys Ala His 
                645                 650                 655     


Phe Asp Gly Lys His Phe Asn Ile Asn Gly Leu Leu Pro Asn Val Arg 
            660                 665                 670         


Trp Val Pro Lys Tyr Ser Gly Ile Leu Met Lys Asp Arg Cys Lys Leu 
        675                 680                 685             


Phe Cys Arg Val Ala Gly Asn Thr Ala Tyr Tyr Gln Leu Arg Asp Arg 
    690                 695                 700                 


Val Ile Asp Gly Thr Pro Cys Gly Gln Asp Thr Asn Asp Ile Cys Val 
705                 710                 715                 720 


Gln Gly Leu Cys Arg Gln Ala Gly Cys Asp His Val Leu Asn Ser Lys 
                725                 730                 735     


Ala Arg Arg Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys 
            740                 745                 750         


Lys Thr Val Ala Gly Thr Phe Asn Thr Val His Tyr Gly Tyr Asn Thr 
        755                 760                 765             


Val Val Arg Ile Pro Ala Gly Ala Thr Asn Ile Asp Val Arg Gln His 
    770                 775                 780                 


Ser Phe Ser Gly Glu Thr Asp Asp Asp Asn Tyr Leu Ala Leu Ser Ser 
785                 790                 795                 800 


Ser Lys Gly Glu Phe Leu Leu Asn Gly Asn Phe Val Val Thr Met Ala 
                805                 810                 815     


Lys Arg Glu Ile Arg Ile Gly Asn Ala Val Val Glu Tyr Ser Gly Ser 
            820                 825                 830         


Glu Thr Ala Val Glu Arg Ile Asn Ser Thr Asp Arg Ile Glu Gln Glu 
        835                 840                 845             


Leu Leu Leu Gln Val Leu Ser Val Gly Lys Leu Tyr Asn Pro Asp Val 
    850                 855                 860                 


Arg Tyr Ser Phe Asn Ile Pro Ile Glu Asp Lys Pro Gln Gln Phe Tyr 
865                 870                 875                 880 


Trp Asn Ser His Gly Pro Trp Gln Ala Cys Ser Lys Pro Cys Gln Gly 
                885                 890                 895     


Glu Arg Lys Arg Lys Leu Val Cys Thr Arg Glu Ser Asp Gln Leu Thr 
            900                 905                 910         


Val Ser Asp Gln Arg Cys Asp Arg Leu Pro Gln Pro Gly His Ile Thr 
        915                 920                 925             


Glu Pro Cys Gly Thr Asp Cys Asp Leu Arg Trp His Val Ala Ser Arg 
    930                 935                 940                 


Ser Glu Cys Ser Ala Gln Cys Gly Leu Gly Tyr Arg Thr Leu Asp Ile 
945                 950                 955                 960 


Tyr Cys Ala Lys Tyr Ser Arg Leu Asp Gly Lys Thr Glu Lys Val Asp 
                965                 970                 975     


Asp Gly Phe Cys Ser Ser His Pro Lys Pro Ser Asn Arg Glu Lys Cys 
            980                 985                 990         


Ser Gly Glu Cys Asn Thr Gly Gly  Trp Arg Tyr Ser Ala  Trp Thr Glu 
        995                 1000                 1005             


Cys Ser  Lys Ser Cys Asp Gly  Gly Thr Gln Arg Arg  Arg Ala Ile 
    1010                 1015                 1020             


Cys Val  Asn Thr Arg Asn Asp  Val Leu Asp Asp Ser  Lys Cys Thr 
    1025                 1030                 1035             


His Gln  Glu Lys Val Thr Ile  Gln Arg Cys Ser Glu  Phe Pro Cys 
    1040                 1045                 1050             


Pro Gln  Trp Lys Ser Gly Asp  Trp Ser Glu Cys Leu  Val Thr Cys 
    1055                 1060                 1065             


Gly Lys  Gly His Lys His Arg  Gln Val Trp Cys Gln  Phe Gly Glu 
    1070                 1075                 1080             


Asp Arg  Leu Asn Asp Arg Met  Cys Asp Pro Glu Thr  Lys Pro Thr 
    1085                 1090                 1095             


Ser Met  Gln Thr Cys Gln Gln  Pro Glu Cys Ala Ser  Trp Gln Ala 
    1100                 1105                 1110             


Gly Pro  Trp Gly Gln Cys Ser  Val Thr Cys Gly Gln  Gly Tyr Gln 
    1115                 1120                 1125             


Leu Arg  Ala Val Lys Cys Ile  Ile Gly Thr Tyr Met  Ser Val Val 
    1130                 1135                 1140             


Asp Asp  Asn Asp Cys Asn Ala  Ala Thr Arg Pro Thr  Asp Thr Gln 
    1145                 1150                 1155             


Asp Cys  Glu Leu Pro Ser Cys  His Pro Pro Pro Ala  Ala Pro Glu 
    1160                 1165                 1170             


Thr Arg  Arg Ser Thr Tyr Ser  Ala Pro Arg Thr Gln  Trp Arg Phe 
    1175                 1180                 1185             


Gly Ser  Trp Thr Pro Cys Ser  Ala Thr Cys Gly Lys  Gly Thr Arg 
    1190                 1195                 1200             


Met Arg  Tyr Val Ser Cys Arg  Asp Glu Asn Gly Ser  Val Ala Asp 
    1205                 1210                 1215             


Glu Ser  Ala Cys Ala Thr Leu  Pro Arg Pro Val Ala  Lys Glu Glu 
    1220                 1225                 1230             


Cys Ser  Val Thr Pro Cys Gly  Gln Trp Lys Ala Leu  Asp Trp Ser 
    1235                 1240                 1245             


Ser Cys  Ser Val Thr Cys Gly  Gln Gly Arg Ala Thr  Arg Gln Val 
    1250                 1255                 1260             


Met Cys  Val Asn Tyr Ser Asp  His Val Ile Asp Arg  Ser Glu Cys 
    1265                 1270                 1275             


Asp Gln  Asp Tyr Ile Pro Glu  Thr Asp Gln Asp Cys  Ser Met Ser 
    1280                 1285                 1290             


Pro Cys  Pro Gln Arg Thr Pro  Asp Ser Gly Leu Ala  Gln His Pro 
    1295                 1300                 1305             


Phe Gln  Asn Glu Asp Tyr Arg  Pro Arg Ser Ala Ser  Pro Ser Arg 
    1310                 1315                 1320             


Thr His  Val Leu Gly Gly Asn  Gln Trp Arg Thr Gly  Pro Trp Gly 
    1325                 1330                 1335             


Ala Cys  Ser Ser Thr Cys Ala  Gly Gly Ser Gln Arg  Arg Val Val 
    1340                 1345                 1350             


Val Cys  Gln Asp Glu Asn Gly  Tyr Thr Ala Asn Asp  Cys Val Glu 
    1355                 1360                 1365             


Arg Ile  Lys Pro Asp Glu Gln  Arg Ala Cys Glu Ser  Gly Pro Cys 
    1370                 1375                 1380             


Pro Gln  Trp Ala Tyr Gly Asn  Trp Gly Glu Cys Thr  Lys Leu Cys 
    1385                 1390                 1395             


Gly Gly  Gly Ile Arg Thr Arg  Leu Val Val Cys Gln  Arg Ser Asn 
    1400                 1405                 1410             


Gly Glu  Arg Phe Pro Asp Leu  Ser Cys Glu Ile Leu  Asp Lys Pro 
    1415                 1420                 1425             


Pro Asp  Arg Glu Gln Cys Asn  Thr His Ala Cys Pro  His Asp Ala 
    1430                 1435                 1440             


Ala Trp  Ser Thr Gly Pro Trp  Ser Ser Cys Ser Val  Ser Cys Gly 
    1445                 1450                 1455             


Arg Gly  His Lys Gln Arg Asn  Val Tyr Cys Met Ala  Lys Asp Gly 
    1460                 1465                 1470             


Ser His  Leu Glu Ser Asp Tyr  Cys Lys His Leu Ala  Lys Pro His 
    1475                 1480                 1485             


Gly His  Arg Lys Cys Arg Gly  Gly Arg Cys Pro Lys  Trp Lys Ala 
    1490                 1495                 1500             


Gly Ala  Trp Ser Gln Cys Ser  Val Ser Cys Gly Arg  Gly Val Gln 
    1505                 1510                 1515             


Gln Arg  His Val Gly Cys Gln  Ile Gly Thr His Lys  Ile Ala Arg 
    1520                 1525                 1530             


Glu Thr  Glu Cys Asn Pro Tyr  Thr Arg Pro Glu Ser  Glu Arg Asp 
    1535                 1540                 1545             


Cys Gln  Gly Pro Arg Cys Pro  Leu Tyr Thr Trp Arg  Ala Glu Glu 
    1550                 1555                 1560             


Trp Gln  Glu Cys Thr Lys Thr  Cys Gly Glu Gly Ser  Arg Tyr Arg 
    1565                 1570                 1575             


Lys Val  Val Cys Val Asp Asp  Asn Lys Asn Glu Val  His Gly Ala 
    1580                 1585                 1590             


Arg Cys  Asp Val Ser Lys Arg  Pro Val Asp Arg Glu  Ser Cys Ser 
    1595                 1600                 1605             


Leu Gln  Pro Cys Glu Tyr Val  Trp Ile Thr Gly Glu  Trp Ser Glu 
    1610                 1615                 1620             


Cys Ser  Val Thr Cys Gly Lys  Gly Tyr Lys Gln Arg  Leu Val Ser 
    1625                 1630                 1635             


Cys Ser  Glu Ile Tyr Thr Gly  Lys Glu Asn Tyr Glu  Tyr Ser Tyr 
    1640                 1645                 1650             


Gln Thr  Thr Ile Asn Cys Pro  Gly Thr Gln Pro Pro  Ser Val His 
    1655                 1660                 1665             


Pro Cys  Tyr Leu Arg Asp Cys  Pro Val Ser Ala Thr  Trp Arg Val 
    1670                 1675                 1680             


Gly Asn  Trp Gly Ser Cys Ser  Val Ser Cys Gly Val  Gly Val Met 
    1685                 1690                 1695             


Gln Arg  Ser Val Gln Cys Leu  Thr Asn Glu Asp Gln  Pro Ser His 
    1700                 1705                 1710             


Leu Cys  His Thr Asp Leu Lys  Pro Glu Glu Arg Lys  Thr Cys Arg 
    1715                 1720                 1725             


Asn Val  Tyr Asn Cys Glu Leu  Pro Gln Asn Cys Lys  Glu Val Lys 
    1730                 1735                 1740             


Arg Leu  Lys Gly Ala Ser Glu  Asp Gly Glu Tyr Phe  Leu Met Ile 
    1745                 1750                 1755             


Arg Gly  Lys Leu Leu Lys Ile  Phe Cys Ala Gly Met  His Ser Asp 
    1760                 1765                 1770             


His Pro  Lys Glu Tyr Val Thr  Leu Val His Gly Asp  Ser Glu Asn 
    1775                 1780                 1785             


Phe Ser  Glu Val Tyr Gly His  Arg Leu His Asn Pro  Thr Glu Cys 
    1790                 1795                 1800             


Pro Tyr  Asn Gly Ser Arg Arg  Asp Asp Cys Gln Cys  Arg Lys Asp 
    1805                 1810                 1815             


Tyr Thr  Ala Ala Gly Phe Ser  Ser Phe Gln Lys Ile  Arg Ile Asp 
    1820                 1825                 1830             


Leu Thr  Ser Met Gln Ile Ile  Thr Thr Asp Leu Gln  Phe Ala Arg 
    1835                 1840                 1845             


Thr Ser  Glu Gly His Pro Val  Pro Phe Ala Thr Ala  Gly Asp Cys 
    1850                 1855                 1860             


Tyr Ser  Ala Ala Lys Cys Pro  Gln Gly Arg Phe Ser  Ile Asn Leu 
    1865                 1870                 1875             


Tyr Gly  Thr Gly Leu Ser Leu  Thr Glu Ser Ala Arg  Trp Ile Ser 
    1880                 1885                 1890             


Gln Gly  Asn Tyr Ala Val Ser  Asp Ile Lys Lys Ser  Pro Asp Gly 
    1895                 1900                 1905             


Thr Arg  Val Val Gly Lys Cys  Gly Gly Tyr Cys Gly  Lys Cys Thr 
    1910                 1915                 1920             


Pro Ser  Ser Gly Thr Gly Leu  Glu Val Arg Val Leu  
    1925                 1930                 1935 


<210>  39
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Leu Leu Leu Gly Ile Leu Thr Leu Ala Phe Ala Gly Arg Thr Ala 
1               5                   10                  15      


Gly Gly Ser Glu Pro Glu Arg Glu Val Val Val Pro Ile Arg Leu Asp 
            20                  25                  30          


Pro Asp Ile Asn Gly Arg Arg Tyr Tyr Trp Arg Gly Pro Glu Asp Ser 
        35                  40                  45              


Gly Asp Gln Gly Leu Ile Phe Gln Ile Thr Ala Phe Gln Glu Asp Phe 
    50                  55                  60                  


Tyr Leu His Leu Thr Pro Asp Ala Gln Phe Leu Ala Pro Ala Phe Ser 
65                  70                  75                  80  


Thr Glu His Leu Gly Val Pro Leu Gln Gly Leu Thr Gly Gly Ser Ser 
                85                  90                  95      


Asp Leu Arg Arg Cys Phe Tyr Ser Gly Asp Val Asn Ala Glu Pro Asp 
            100                 105                 110         


Ser Phe Ala Ala Val Ser Leu Cys Gly Gly Leu Arg Gly Ala Phe Gly 
        115                 120                 125             


Tyr Arg Gly Ala Glu Tyr Val Ile Ser Pro Leu Pro Asn Ala Ser Ala 
    130                 135                 140                 


Pro Ala Ala Gln Arg Asn Ser Gln Gly Ala His Leu Leu Gln Arg Arg 
145                 150                 155                 160 


Gly Val Pro Gly Gly Pro Ser Gly Asp Pro Thr Ser Arg Cys Gly Val 
                165                 170                 175     


Ala Ser Gly Trp Asn Pro Ala Ile Leu Arg Ala Leu Asp Pro Tyr Lys 
            180                 185                 190         


Pro Arg Arg Ala Gly Phe Gly Glu Ser Arg Ser Arg Arg Arg Ser Gly 
        195                 200                 205             


Arg Ala Lys Arg Phe Val Ser Ile Pro Arg Tyr Val Glu Thr Leu Val 
    210                 215                 220                 


Val Ala Asp Glu Ser Met Val Lys Phe His Gly Ala Asp Leu Glu His 
225                 230                 235                 240 


Tyr Leu Leu Thr Leu Leu Ala Thr Ala Ala Arg Leu Tyr Arg His Pro 
                245                 250                 255     


Ser Ile Leu Asn Pro Ile Asn Ile Val Val Val Lys Val Leu Leu Leu 
            260                 265                 270         


Arg Asp Arg Asp Ser Gly Pro Lys Val Thr Gly Asn Ala Ala Leu Thr 
        275                 280                 285             


Leu Arg Asn Phe Cys Ala Trp Gln Lys Lys Leu Asn Lys Val Ser Asp 
    290                 295                 300                 


Lys His Pro Glu Tyr Trp Asp Thr Ala Ile Leu Phe Thr Arg Gln Asp 
305                 310                 315                 320 


Leu Cys Gly Ala Thr Thr Cys Asp Thr Leu Gly Met Ala Asp Val Gly 
                325                 330                 335     


Thr Met Cys Asp Pro Lys Arg Ser Cys Ser Val Ile Glu Asp Asp Gly 
            340                 345                 350         


Leu Pro Ser Ala Phe Thr Thr Ala His Glu Leu Gly His Val Phe Asn 
        355                 360                 365             


Met Pro His Asp Asn Val Lys Val Cys Glu Glu Val Phe Gly Lys Leu 
    370                 375                 380                 


Arg Ala Asn His Met Met Ser Pro Thr Leu Ile Gln Ile Asp Arg Ala 
385                 390                 395                 400 


Asn Pro Trp Ser Ala Cys Ser Ala Ala Ile Ile Thr Asp Phe Leu Asp 
                405                 410                 415     


Ser Gly His Gly Asp Cys Leu Leu Asp Gln Pro Ser Lys Pro Ile Ser 
            420                 425                 430         


Leu Pro Glu Asp Leu Pro Gly Ala Ser Tyr Thr Leu Ser Gln Gln Cys 
        435                 440                 445             


Glu Leu Ala Phe Gly Val Gly Ser Lys Pro Cys Pro Tyr Met Gln Tyr 
    450                 455                 460                 


Cys Thr Lys Leu Trp Cys Thr Gly Lys Ala Lys Gly Gln Met Val Cys 
465                 470                 475                 480 


Gln Thr Arg His Phe Pro Trp Ala Asp Gly Thr Ser Cys Gly Glu Gly 
                485                 490                 495     


Lys Leu Cys Leu Lys Gly Ala Cys Val Glu Arg His Asn Leu Asn Lys 
            500                 505                 510         


His Arg Val Asp Gly Ser Trp Ala Lys Trp Asp Pro Tyr Gly Pro Cys 
        515                 520                 525             


Ser Arg Thr Cys Gly Gly Gly Val Gln Leu Ala Arg Arg Gln Cys Thr 
    530                 535                 540                 


Asn Pro Thr Pro Ala Asn Gly Gly Lys Tyr Cys Glu Gly Val Arg Val 
545                 550                 555                 560 


Lys Tyr Arg Ser Cys Asn Leu Glu Pro Cys Pro Ser Ser Ala Ser Gly 
                565                 570                 575     


Lys Ser Phe Arg Glu Glu Gln Cys Glu Ala Phe Asn Gly Tyr Asn His 
            580                 585                 590         


Ser Thr Asn Arg Leu Thr Leu Ala Val Ala Trp Val Pro Lys Tyr Ser 
        595                 600                 605             


Gly Val Ser Pro Arg Asp Lys Cys Lys Leu Ile Cys Arg Ala Asn Gly 
    610                 615                 620                 


Thr Gly Tyr Phe Tyr Val Leu Ala Pro Lys Val Val Asp Gly Thr Leu 
625                 630                 635                 640 


Cys Ser Pro Asp Ser Thr Ser Val Cys Val Gln Gly Lys Cys Ile Lys 
                645                 650                 655     


Ala Gly Cys Asp Gly Asn Leu Gly Ser Lys Lys Arg Phe Asp Lys Cys 
            660                 665                 670         


Gly Val Cys Gly Gly Asp Asn Lys Ser Cys Lys Lys Val Thr Gly Leu 
        675                 680                 685             


Phe Thr Lys Pro Met His Gly Tyr Asn Phe Val Val Ala Ile Pro Ala 
    690                 695                 700                 


Gly Ala Ser Ser Ile Asp Ile Arg Gln Arg Gly Tyr Lys Gly Leu Ile 
705                 710                 715                 720 


Gly Asp Asp Asn Tyr Leu Ala Leu Lys Asn Ser Gln Gly Lys Tyr Leu 
                725                 730                 735     


Leu Asn Gly His Phe Val Val Ser Ala Val Glu Arg Asp Leu Val Val 
            740                 745                 750         


Lys Gly Ser Leu Leu Arg Tyr Ser Gly Thr Gly Thr Ala Val Glu Ser 
        755                 760                 765             


Leu Gln Ala Ser Arg Pro Ile Leu Glu Pro Leu Thr Val Glu Val Leu 
    770                 775                 780                 


Ser Val Gly Lys Met Thr Pro Pro Arg Val Arg Tyr Ser Phe Tyr Leu 
785                 790                 795                 800 


Pro Lys Glu Pro Arg Glu Asp Lys Ser Ser His Pro Lys Asp Pro Arg 
                805                 810                 815     


Gly Pro Ser Val Leu His Asn Ser Val Leu Ser Leu Ser Asn Gln Val 
            820                 825                 830         


Glu Gln Pro Asp Asp Arg Pro Pro Ala Arg Trp Val Ala Gly Ser Trp 
        835                 840                 845             


Gly Pro Cys Ser Ala Ser Cys Gly Ser Gly Leu Gln Lys Arg Ala Val 
    850                 855                 860                 


Asp Cys Arg Gly Ser Ala Gly Gln Arg Thr Val Pro Ala Cys Asp Ala 
865                 870                 875                 880 


Ala His Arg Pro Val Glu Thr Gln Ala Cys Gly Glu Pro Cys Pro Thr 
                885                 890                 895     


Trp Glu Leu Ser Ala Trp Ser Pro Cys Ser Lys Ser Cys Gly Arg Gly 
            900                 905                 910         


Phe Gln Arg Arg Ser Leu Lys Cys Val Gly His Gly Gly Arg Leu Leu 
        915                 920                 925             


Ala Arg Asp Gln Cys Asn Leu His Arg Lys Pro Gln Glu Leu Asp Phe 
    930                 935                 940                 


Cys Val Leu Arg Pro Cys 
945                 950 


<210>  40
<211>  1910
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Trp Val Ala Lys Trp Leu Thr Gly Leu Leu Tyr His Leu Ser Leu 
1               5                   10                  15      


Phe Ile Thr Arg Ser Trp Glu Val Asp Phe His Pro Arg Gln Glu Ala 
            20                  25                  30          


Leu Val Arg Thr Leu Thr Ser Tyr Glu Val Val Ile Pro Glu Arg Val 
        35                  40                  45              


Asn Glu Phe Gly Glu Val Phe Pro Gln Ser His His Phe Ser Arg Gln 
    50                  55                  60                  


Lys Arg Ser Ser Glu Ala Leu Glu Pro Met Pro Phe Arg Thr His Tyr 
65                  70                  75                  80  


Arg Phe Thr Ala Tyr Gly Gln Leu Phe Gln Leu Asn Leu Thr Ala Asp 
                85                  90                  95      


Ala Ser Phe Leu Ala Ala Gly Tyr Thr Glu Val His Leu Gly Thr Pro 
            100                 105                 110         


Glu Arg Gly Ala Trp Glu Ser Asp Ala Gly Pro Ser Asp Leu Arg His 
        115                 120                 125             


Cys Phe Tyr Arg Gly Gln Val Asn Ser Gln Glu Asp Tyr Lys Ala Val 
    130                 135                 140                 


Val Ser Leu Cys Gly Gly Leu Thr Gly Thr Phe Lys Gly Gln Asn Gly 
145                 150                 155                 160 


Glu Tyr Phe Leu Glu Pro Ile Met Lys Ala Asp Gly Asn Glu Tyr Glu 
                165                 170                 175     


Asp Gly His Asn Lys Pro His Leu Ile Tyr Arg Gln Asp Leu Asn Asn 
            180                 185                 190         


Ser Phe Leu Gln Thr Leu Lys Tyr Cys Ser Val Ser Glu Ser Gln Ile 
        195                 200                 205             


Lys Glu Thr Ser Leu Pro Phe His Thr Tyr Ser Asn Met Asn Glu Asp 
    210                 215                 220                 


Leu Asn Val Met Lys Glu Arg Val Leu Gly His Thr Ser Lys Asn Val 
225                 230                 235                 240 


Pro Leu Lys Asp Glu Arg Arg His Ser Arg Lys Lys Arg Leu Ile Ser 
                245                 250                 255     


Tyr Pro Arg Tyr Ile Glu Ile Met Val Thr Ala Asp Ala Lys Val Val 
            260                 265                 270         


Ser Ala His Gly Ser Asn Leu Gln Asn Tyr Ile Leu Thr Leu Met Ser 
        275                 280                 285             


Ile Val Ala Thr Ile Tyr Lys Asp Pro Ser Ile Gly Asn Leu Ile His 
    290                 295                 300                 


Ile Val Val Val Lys Leu Val Met Ile His Arg Glu Glu Glu Gly Pro 
305                 310                 315                 320 


Val Ile Asn Phe Asp Gly Ala Thr Thr Leu Lys Asn Phe Cys Ser Trp 
                325                 330                 335     


Gln Gln Thr Gln Asn Asp Leu Asp Asp Val His Pro Ser His His Asp 
            340                 345                 350         


Thr Ala Val Leu Ile Thr Arg Glu Asp Ile Cys Ser Ser Lys Glu Lys 
        355                 360                 365             


Cys Asn Met Leu Gly Leu Ser Tyr Leu Gly Thr Ile Cys Asp Pro Leu 
    370                 375                 380                 


Gln Ser Cys Phe Ile Asn Glu Glu Lys Gly Leu Ile Ser Ala Phe Thr 
385                 390                 395                 400 


Ile Ala His Glu Leu Gly His Thr Leu Gly Val Gln His Asp Asp Asn 
                405                 410                 415     


Pro Arg Cys Lys Glu Met Lys Val Thr Lys Tyr His Val Met Ala Pro 
            420                 425                 430         


Ala Leu Ser Phe His Met Ser Pro Trp Ser Trp Ser Asn Cys Ser Arg 
        435                 440                 445             


Lys Tyr Val Thr Glu Phe Leu Asp Thr Gly Tyr Gly Glu Cys Leu Leu 
    450                 455                 460                 


Asp Lys Pro Asp Glu Glu Ile Tyr Asn Leu Pro Ser Glu Leu Pro Gly 
465                 470                 475                 480 


Ser Arg Tyr Asp Gly Asn Lys Gln Cys Glu Leu Ala Phe Gly Pro Gly 
                485                 490                 495     


Ser Gln Met Cys Pro His Ile Asn Ile Cys Met His Leu Trp Cys Thr 
            500                 505                 510         


Ser Thr Glu Lys Leu His Lys Gly Cys Phe Thr Gln His Val Pro Pro 
        515                 520                 525             


Ala Asp Gly Thr Asp Cys Gly Pro Gly Met His Cys Arg His Gly Leu 
    530                 535                 540                 


Cys Val Asn Lys Glu Thr Glu Thr Arg Pro Val Asn Gly Glu Trp Gly 
545                 550                 555                 560 


Pro Trp Glu Pro Tyr Ser Ser Cys Ser Arg Thr Cys Gly Gly Gly Ile 
                565                 570                 575     


Glu Ser Ala Thr Arg Arg Cys Asn Arg Pro Glu Pro Arg Asn Gly Gly 
            580                 585                 590         


Asn Tyr Cys Val Gly Arg Arg Met Lys Phe Arg Ser Cys Asn Thr Asp 
        595                 600                 605             


Ser Cys Pro Lys Gly Thr Gln Asp Phe Arg Glu Lys Gln Cys Ser Asp 
    610                 615                 620                 


Phe Asn Gly Lys His Leu Asp Ile Ser Gly Ile Pro Ser Asn Val Arg 
625                 630                 635                 640 


Trp Leu Pro Arg Tyr Ser Gly Ile Gly Thr Lys Asp Arg Cys Lys Leu 
                645                 650                 655     


Tyr Cys Gln Val Ala Gly Thr Asn Tyr Phe Tyr Leu Leu Lys Asp Met 
            660                 665                 670         


Val Glu Asp Gly Thr Pro Cys Gly Thr Glu Thr His Asp Ile Cys Val 
        675                 680                 685             


Gln Gly Gln Cys Met Ala Ala Gly Cys Asp His Val Leu Asn Ser Ser 
    690                 695                 700                 


Ala Lys Ile Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys 
705                 710                 715                 720 


Lys Thr Ile Thr Gly Val Phe Asn Ser Ser His Tyr Gly Tyr Asn Val 
                725                 730                 735     


Val Val Lys Ile Pro Ala Gly Ala Thr Asn Val Asp Ile Arg Gln Tyr 
            740                 745                 750         


Ser Tyr Ser Gly Gln Pro Asp Asp Ser Tyr Leu Ala Leu Ser Asp Ala 
        755                 760                 765             


Glu Gly Asn Phe Leu Phe Asn Gly Asn Phe Leu Leu Ser Thr Ser Lys 
    770                 775                 780                 


Lys Glu Ile Asn Val Gln Gly Thr Arg Thr Val Ile Glu Tyr Ser Gly 
785                 790                 795                 800 


Ser Asn Asn Ala Val Glu Arg Ile Asn Ser Thr Asn Arg Gln Glu Lys 
                805                 810                 815     


Glu Ile Leu Ile Glu Val Leu Cys Val Gly Asn Leu Tyr Asn Pro Asp 
            820                 825                 830         


Val His Tyr Ser Phe Asn Ile Pro Leu Glu Glu Arg Ser Asp Met Phe 
        835                 840                 845             


Thr Trp Asp Pro Tyr Gly Pro Trp Glu Gly Cys Thr Lys Met Cys Gln 
    850                 855                 860                 


Gly Leu Gln Arg Arg Asn Ile Thr Cys Ile His Lys Ser Asp His Ser 
865                 870                 875                 880 


Val Val Ser Asp Lys Glu Cys Asp His Leu Pro Leu Pro Ser Phe Val 
                885                 890                 895     


Thr Gln Ser Cys Asn Thr Asp Cys Glu Leu Arg Trp His Val Ile Gly 
            900                 905                 910         


Lys Ser Glu Cys Ser Ser Gln Cys Gly Gln Gly Tyr Arg Thr Leu Asp 
        915                 920                 925             


Ile His Cys Met Lys Tyr Ser Ile His Glu Gly Gln Thr Val Gln Val 
    930                 935                 940                 


Asp Asp His Tyr Cys Gly Asp Gln Leu Lys Pro Pro Thr Gln Glu Leu 
945                 950                 955                 960 


Cys His Gly Asn Cys Val Phe Thr Arg Trp His Tyr Ser Glu Trp Ser 
                965                 970                 975     


Gln Cys Ser Arg Ser Cys Gly Gly Gly Glu Arg Ser Arg Glu Ser Tyr 
            980                 985                 990         


Cys Met Asn Asn Phe Gly His Arg  Leu Ala Asp Asn Glu  Cys Gln Glu 
        995                 1000                 1005             


Leu Ser  Arg Val Thr Arg Glu  Asn Cys Asn Glu Phe  Ser Cys Pro 
    1010                 1015                 1020             


Ser Trp  Ala Ala Ser Glu Trp  Ser Glu Cys Leu Val  Thr Cys Gly 
    1025                 1030                 1035             


Lys Gly  Thr Lys Gln Arg Gln  Val Trp Cys Gln Leu  Asn Val Asp 
    1040                 1045                 1050             


His Leu  Ser Asp Gly Phe Cys  Asn Ser Ser Thr Lys  Pro Glu Ser 
    1055                 1060                 1065             


Leu Ser  Pro Cys Glu Leu His  Thr Cys Ala Ser Trp  Gln Val Gly 
    1070                 1075                 1080             


Pro Trp  Gly Pro Cys Thr Thr  Thr Cys Gly His Gly  Tyr Gln Met 
    1085                 1090                 1095             


Arg Asp  Val Lys Cys Val Asn  Glu Leu Ala Ser Ala  Val Leu Glu 
    1100                 1105                 1110             


Asp Thr  Glu Cys His Glu Ala  Ser Arg Pro Ser Asp  Arg Gln Ser 
    1115                 1120                 1125             


Cys Val  Leu Thr Pro Cys Ser  Phe Ile Ser Lys Leu  Glu Thr Ala 
    1130                 1135                 1140             


Leu Leu  Pro Thr Val Leu Ile  Lys Lys Met Ala Gln  Trp Arg His 
    1145                 1150                 1155             


Gly Ser  Trp Thr Pro Cys Ser  Val Ser Cys Gly Arg  Gly Thr Gln 
    1160                 1165                 1170             


Ala Arg  Tyr Val Ser Cys Arg  Asp Ala Leu Asp Arg  Ile Ala Asp 
    1175                 1180                 1185             


Glu Ser  Tyr Cys Ala His Leu  Pro Arg Pro Ala Glu  Ile Trp Asp 
    1190                 1195                 1200             


Cys Phe  Thr Pro Cys Gly Glu  Trp Gln Ala Gly Asp  Trp Ser Pro 
    1205                 1210                 1215             


Cys Ser  Ala Ser Cys Gly His  Gly Lys Thr Thr Arg  Gln Val Leu 
    1220                 1225                 1230             


Cys Met  Asn Tyr His Gln Pro  Ile Asp Glu Asn Tyr  Cys Asp Pro 
    1235                 1240                 1245             


Glu Val  Arg Pro Leu Met Glu  Gln Glu Cys Ser Leu  Ala Ala Cys 
    1250                 1255                 1260             


Pro Pro  Ala His Ser His Phe  Pro Ser Ser Pro Val  Gln Pro Ser 
    1265                 1270                 1275             


Tyr Tyr  Leu Ser Thr Asn Leu  Pro Leu Thr Gln Lys  Leu Glu Asp 
    1280                 1285                 1290             


Asn Glu  Asn Gln Val Val His  Pro Ser Val Arg Gly  Asn Gln Trp 
    1295                 1300                 1305             


Arg Thr  Gly Pro Trp Gly Ser  Cys Ser Ser Ser Cys  Ser Gly Gly 
    1310                 1315                 1320             


Leu Gln  His Arg Ala Val Val  Cys Gln Asp Glu Asn  Gly Gln Ser 
    1325                 1330                 1335             


Ala Ser  Tyr Cys Asp Ala Ala  Ser Lys Pro Pro Glu  Leu Gln Gln 
    1340                 1345                 1350             


Cys Gly  Pro Gly Pro Cys Pro  Gln Trp Asn Tyr Gly  Asn Trp Gly 
    1355                 1360                 1365             


Glu Cys  Ser Gln Thr Cys Gly  Gly Gly Ile Lys Ser  Arg Leu Val 
    1370                 1375                 1380             


Ile Cys  Gln Phe Pro Asn Gly  Gln Ile Leu Glu Asp  His Asn Cys 
    1385                 1390                 1395             


Glu Ile  Val Asn Lys Pro Pro  Ser Val Ile Gln Cys  His Met His 
    1400                 1405                 1410             


Ala Cys  Pro Ala Asp Val Ser  Trp His Gln Glu Pro  Trp Thr Ser 
    1415                 1420                 1425             


Cys Ser  Ala Ser Cys Gly Lys  Gly Arg Lys Tyr Arg  Glu Val Phe 
    1430                 1435                 1440             


Cys Ile  Asp Gln Phe Gln Arg  Lys Leu Glu Asp Thr  Asn Cys Ser 
    1445                 1450                 1455             


Gln Val  Gln Lys Pro Pro Thr  His Lys Ala Cys Arg  Ser Val Arg 
    1460                 1465                 1470             


Cys Pro  Ser Trp Lys Ala Asn  Ser Trp Asn Glu Cys  Ser Val Thr 
    1475                 1480                 1485             


Cys Gly  Ser Gly Val Gln Gln  Arg Asp Val Tyr Cys  Arg Leu Lys 
    1490                 1495                 1500             


Gly Val  Gly Gln Val Val Glu  Glu Met Cys Asp Gln  Ser Thr Arg 
    1505                 1510                 1515             


Pro Cys  Ser Gln Arg Arg Cys  Trp Ser Gln Asp Cys  Val Gln His 
    1520                 1525                 1530             


Lys Gly  Met Glu Arg Gly Arg  Leu Asn Cys Ser Thr  Ser Cys Glu 
    1535                 1540                 1545             


Arg Lys  Asp Ser His Gln Arg  Met Glu Cys Thr Asp  Asn Gln Ile 
    1550                 1555                 1560             


Arg Gln  Val Asn Glu Ile Val  Tyr Asn Ser Ser Thr  Ile Ser Leu 
    1565                 1570                 1575             


Thr Ser  Lys Asn Cys Arg Asn  Pro Pro Cys Asn Tyr  Ile Val Val 
    1580                 1585                 1590             


Thr Ala  Asp Ser Ser Gln Cys  Ala Asn Asn Cys Gly  Phe Ser Tyr 
    1595                 1600                 1605             


Arg Gln  Arg Ile Thr Tyr Cys  Thr Glu Ile Pro Ser  Thr Lys Lys 
    1610                 1615                 1620             


His Lys  Leu His Arg Leu Arg  Pro Ile Val Tyr Gln  Glu Cys Pro 
    1625                 1630                 1635             


Val Val  Pro Ser Ser Gln Val  Tyr Gln Cys Ile Asn  Ser Cys Leu 
    1640                 1645                 1650             


His Leu  Ala Thr Trp Lys Val  Gly Lys Trp Ser Lys  Cys Ser Val 
    1655                 1660                 1665             


Thr Cys  Gly Ile Gly Ile Met  Lys Arg Gln Val Lys  Cys Ile Thr 
    1670                 1675                 1680             


Lys His  Gly Leu Ser Ser Asp  Leu Cys Leu Asn His  Leu Lys Pro 
    1685                 1690                 1695             


Gly Ala  Gln Lys Lys Cys Tyr  Ala Asn Asp Cys Lys  Ser Phe Thr 
    1700                 1705                 1710             


Thr Cys  Lys Glu Ile Gln Val  Lys Asn His Ile Arg  Lys Asp Gly 
    1715                 1720                 1725             


Asp Tyr  Tyr Leu Asn Ile Lys  Gly Arg Ile Ile Lys  Ile Tyr Cys 
    1730                 1735                 1740             


Ala Asp  Met Tyr Leu Glu Asn  Pro Lys Glu Tyr Leu  Thr Leu Val 
    1745                 1750                 1755             


Gln Gly  Glu Glu Asn Phe Ser  Glu Val Tyr Gly Phe  Arg Leu Lys 
    1760                 1765                 1770             


Asn Pro  Tyr Gln Cys Pro Phe  Asn Gly Ser Arg Arg  Glu Asp Cys 
    1775                 1780                 1785             


Glu Cys  Asp Asn Gly His Leu  Ala Ala Gly Tyr Thr  Val Phe Ser 
    1790                 1795                 1800             


Lys Ile  Arg Ile Asp Leu Thr  Ser Met Gln Ile Lys  Thr Thr Asp 
    1805                 1810                 1815             


Leu Leu  Phe Ser Lys Thr Ile  Phe Gly Asn Ala Val  Pro Phe Ala 
    1820                 1825                 1830             


Thr Ala  Gly Asp Cys Tyr Ser  Ala Phe Arg Cys Pro  Gln Gly Gln 
    1835                 1840                 1845             


Phe Ser  Ile Asn Leu Ser Gly  Thr Gly Met Lys Ile  Ser Ser Thr 
    1850                 1855                 1860             


Ala Lys  Trp Leu Thr Gln Gly  Ser Tyr Thr Ser Val  Ser Ile Arg 
    1865                 1870                 1875             


Arg Ser  Glu Asp Gly Thr Arg  Phe Phe Gly Lys Cys  Gly Gly Tyr 
    1880                 1885                 1890             


Cys Gly  Lys Cys Leu Pro His  Met Thr Thr Gly Leu  Pro Ile Gln 
    1895                 1900                 1905             


Val Ile  
    1910 


<210>  41
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 
            20                  25                  30          


Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 
        35                  40                  45              


Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 
    50                  55                  60                  


Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 
65                  70                  75                  80  


Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 
                85                  90                  95      


Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 
            100                 105                 110         


Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 
        115                 120                 125             


Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 
    130                 135                 140                 


Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 
145                 150                 155                 160 


Lys Asn Ser Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr Phe 
                165                 170                 175     


Ala Asn Cys Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu Leu 
            180                 185                 190         


Arg Thr Ala Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu Leu 
        195                 200                 205             


Asp Tyr Cys Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly Asn 
    210                 215                 220                 


Glu Pro Asn Ser Phe Leu Lys Lys Ala Asp Ile Phe Ile Asn Gly Ser 
225                 230                 235                 240 


Gln Leu Gly Glu Asp Phe Ile Gln Leu His Lys Leu Leu Arg Lys Ser 
                245                 250                 255     


Thr Phe Lys Asn Ala Lys Leu Tyr Gly Pro Asp Val Gly Gln Pro Arg 
            260                 265                 270         


Arg Lys Thr Ala Lys Met Leu Lys Ser Phe Leu Lys Ala Gly Gly Glu 
        275                 280                 285             


Val Ile Asp Ser Val Thr Trp His His Tyr Tyr Leu Asn Gly Arg Thr 
    290                 295                 300                 


Ala Thr Lys Glu Asp Phe Leu Asn Pro Asp Val Leu Asp Ile Phe Ile 
305                 310                 315                 320 


Ser Ser Val Gln Lys Val Phe Gln Val Val Glu Ser Thr Arg Pro Gly 
                325                 330                 335     


Lys Lys Val Trp Leu Gly Glu Thr Ser Ser Ala Tyr Gly Gly Gly Ala 
            340                 345                 350         


Pro Leu Leu Ser Asp Thr Phe Ala Ala Gly Phe Met Trp Leu Asp Lys 
        355                 360                 365             


Leu Gly Leu Ser Ala Arg Met Gly Ile Glu Val Val Met Arg Gln Val 
    370                 375                 380                 


Phe Phe Gly Ala Gly Asn Tyr His Leu Val Asp Glu Asn Phe Asp Pro 
385                 390                 395                 400 


Leu Pro Asp Tyr Trp Leu Ser Leu Leu Phe Lys Lys Leu Val Gly Thr 
                405                 410                 415     


Lys Val Leu Met Ala Ser Val Gln Gly Ser Lys Arg Arg Lys Leu Arg 
            420                 425                 430         


Val Tyr Leu His Cys Thr Asn Thr Asp Asn Pro Arg Tyr Lys Glu Gly 
        435                 440                 445             


Asp Leu Thr Leu Tyr Ala Ile Asn Leu His Asn Val Thr Lys Tyr Leu 
    450                 455                 460                 


Arg Leu Pro Tyr Pro Phe Ser Asn Lys Gln Val Asp Lys Tyr Leu Leu 
465                 470                 475                 480 


Arg Pro Leu Gly Pro His Gly Leu Leu Ser Lys Ser Val Gln Leu Asn 
                485                 490                 495     


Gly Leu Thr Leu Lys Met Val Asp Asp Gln Thr Leu Pro Pro Leu Met 
            500                 505                 510         


Glu Lys Pro Leu Arg Pro Gly Ser Ser Leu Gly Leu Pro Ala Phe Ser 
        515                 520                 525             


Tyr Ser Phe Phe Val Ile Arg Asn Ala Lys Val Ala Ala Cys Ile 
    530                 535                 540             


<210>  42
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  43
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Ala Ser 
            20              


<210>  44
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  44

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Ala 
            20          


<210>  45
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  45

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Ala Ser 
            20              


<210>  46
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Thr Leu Gly Arg Arg Leu Ala Cys Leu Phe Leu Ala Cys Val Leu 
1               5                   10                  15      


Pro Ala Leu Leu Leu Gly Gly Thr Ala Leu Ala 
            20                  25          


<210>  47
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ser Leu Trp Gln Pro Leu Val Leu Val Leu Leu Val Leu Gly Cys 
1               5                   10                  15      


Cys Phe Ala Met Arg Thr Pro Arg Cys Gly Val Pro Asp Leu Gly Arg 
            20                  25                  30          


Phe Gln Thr Phe Glu Gly Asp Leu Lys Trp His His His Asn Ile Thr 
        35                  40                  45              


Tyr Trp Ile Gln Asn Tyr Ser Glu Asp Leu Pro Arg Ala Val Ile Asp 
    50                  55                  60                  


Asp Ala Phe Ala Arg Ala Phe Ala Leu Trp Ser Ala Val Thr Pro Leu 
65                  70                  75                  80  


Thr Phe Thr Arg Val Tyr Ser Arg Asp Ala Asp Ile Val Ile Gln Phe 
                85                  90                  95      


Gly Val Ala Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly 
            100                 105                 110         


Leu Leu Ala His Ala Phe Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala 
        115                 120                 125             


His Phe Asp Asp Asp Glu Leu Trp Ser Leu Gly Lys Gly Val Val Val 
    130                 135                 140                 


Pro Thr Arg Phe Gly Asn Ala Asp Gly Ala Ala Cys His Phe Pro Phe 
145                 150                 155                 160 


Ile Phe Glu Gly Arg Ser Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser 
                165                 170                 175     


Asp Gly Leu Pro Trp Cys Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp 
            180                 185                 190         


Arg Phe Gly Phe Cys Pro Ser Glu Arg Leu Tyr Thr Gln Asp Gly Asn 
        195                 200                 205             


Ala Asp Gly Lys Pro Cys Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser 
    210                 215                 220                 


Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys 
225                 230                 235                 240 


Ala Thr Thr Ala Asn Tyr Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro 
                245                 250                 255     


Thr Arg Ala Asp Ser Thr Val Met Gly Gly Asn Ser Ala Gly Glu Leu 
            260                 265                 270         


Cys Val Phe Pro Phe Thr Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr 
        275                 280                 285             


Ser Glu Gly Arg Gly Asp Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn 
    290                 295                 300                 


Phe Asp Ser Asp Lys Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser 
305                 310                 315                 320 


Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ala Leu Gly Leu Asp 
                325                 330                 335     


His Ser Ser Val Pro Glu Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr 
            340                 345                 350         


Glu Gly Pro Pro Leu His Lys Asp Asp Val Asn Gly Ile Arg His Leu 
        355                 360                 365             


Tyr Gly Pro Arg Pro Glu Pro Glu Pro Arg Pro Pro Thr Thr Thr Thr 
    370                 375                 380                 


Pro Gln Pro Thr Ala Pro Pro Thr Val Cys Pro Thr Gly Pro Pro Thr 
385                 390                 395                 400 


Val His Pro Ser Glu Arg Pro Thr Ala Gly Pro Thr Gly Pro Pro Ser 
                405                 410                 415     


Ala Gly Pro Thr Gly Pro Pro Thr Ala Gly Pro Ser Thr Ala Thr Thr 
            420                 425                 430         


Val Pro Leu Ser Pro Val Asp Asp Ala Cys Asn Val Asn Ile Phe Asp 
        435                 440                 445             


Ala Ile Ala Glu Ile Gly Asn Gln Leu Tyr Leu Phe Lys Asp Gly Lys 
    450                 455                 460                 


Tyr Trp Arg Phe Ser Glu Gly Arg Gly Ser Arg Pro Gln Gly Pro Phe 
465                 470                 475                 480 


Leu Ile Ala Asp Lys Trp Pro Ala Leu Pro Arg Lys Leu Asp Ser Val 
                485                 490                 495     


Phe Glu Glu Arg Leu Ser Lys Lys Leu Phe Phe Phe Ser Gly Arg Gln 
            500                 505                 510         


Val Trp Val Tyr Thr Gly Ala Ser Val Leu Gly Pro Arg Arg Leu Asp 
        515                 520                 525             


Lys Leu Gly Leu Gly Ala Asp Val Ala Gln Val Thr Gly Ala Leu Arg 
    530                 535                 540                 


Ser Gly Arg Gly Lys Met Leu Leu Phe Ser Gly Arg Arg Leu Trp Arg 
545                 550                 555                 560 


Phe Asp Val Lys Ala Gln Met Val Asp Pro Arg Ser Ala Ser Glu Val 
                565                 570                 575     


Asp Arg Met Phe Pro Gly Val Pro Leu Asp Thr His Asp Val Phe Gln 
            580                 585                 590         


Tyr Arg Glu Lys Ala Tyr Phe Cys Gln Asp Arg Phe Tyr Trp Arg Val 
        595                 600                 605             


Ser Ser Arg Ser Glu Leu Asn Gln Val Asp Gln Val Gly Tyr Val Thr 
    610                 615                 620                 


Tyr Asp Ile Leu Gln Cys Pro Glu Asp 
625                 630             


<210>  48
<211>  1089
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  48
tcgaggtcga cggtatcgat aagcttgata tcgaattagg aggaaaaact gtttcataca       60

gaaggcgtca attaggagga aaaactgttt catacagaag gcgtcaatta ggaggaaaaa      120

ctgtttcata cagaaggcgt caattggtcc catcgaatta ggaggaaaaa ctgtttcata      180

cagaaggcgt caattaggag gaaaaactgt ttcatacaga aggcgtcaat taggaggaaa      240

aactgtttca tacagaaggc gtcaattggt cccgggacat tttgacaccc ccataatatt      300

tttccagaat taacagtata aattgcatct cttgttcaag agttccctat cactctcttt      360

aatcactact cacagtaacc tcaactcctg gccaccatgt ggggactgaa ggtgctgctg      420

ctgcccgtgg tgagctttgc cagagccccc gacagcgtgg actatagaaa gaagggctac      480

gtcacccccg tgaagaatca aggccagtgc ggcagctgct gggcctttag ctccgtgggc      540

gctctggagg gacagctgaa gaagaagacc ggcaagctgc tcaatctgag cccccaaaac      600

ctcgtggact gcgtgagcga gaatgatggc tgtggaggcg gctatatgac caacgccttc      660

cagtacgtgc agaagaatag aggcatcgac agcgaagacg cctaccccta cgtgggccaa      720

gaggagagct gcatgtacaa tcccaccggc aaggctgcca aatgtagagg ctacagagag      780

atccccgagg gcaacgagaa ggctctgaag agggctgtcg ctagggtggg acccgtgagc      840

gtcgccatcg atgcctctct gacaagcttc cagttctaca gcaagggcgt gtactacgac      900

gagagctgca acagcgacaa tctgaaccac gccgtgctcg ctgtgggata cggcatccag      960

aagggcaaca agcactggat catcaagaac agctggggcg agaactgggg caacaagggc     1020

tacattctga tggctagaaa caagaacaac gcttgcggca tcgccaatct ggccagcttc     1080

cccaagatg                                                             1089


<210>  49
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  49

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ile Val Gly Gly Arg Arg Ala Arg Pro His Ala Trp 
            20                  25                  30          


Pro Phe Met Val Ser Leu Gln Leu Arg Gly Gly His Phe Cys Gly Ala 
        35                  40                  45              


Thr Leu Ile Ala Pro Asn Phe Val Met Ser Ala Ala His Cys Val Ala 
    50                  55                  60                  


Asn Val Asn Val Arg Ala Val Arg Val Val Leu Gly Ala His Asn Leu 
65                  70                  75                  80  


Ser Arg Arg Glu Pro Thr Arg Gln Val Phe Ala Val Gln Arg Ile Phe 
                85                  90                  95      


Glu Asn Gly Tyr Asp Pro Val Asn Leu Leu Asn Asp Ile Val Ile Leu 
            100                 105                 110         


Gln Leu Asn Gly Ser Ala Thr Ile Asn Ala Asn Val Gln Val Ala Gln 
        115                 120                 125             


Leu Pro Ala Gln Gly Arg Arg Leu Gly Asn Gly Val Gln Cys Leu Ala 
    130                 135                 140                 


Met Gly Trp Gly Leu Leu Gly Arg Asn Arg Gly Ile Ala Ser Val Leu 
145                 150                 155                 160 


Gln Glu Leu Asn Val Thr Val Val Thr Ser Leu Cys Arg Arg Ser Asn 
                165                 170                 175     


Val Cys Thr Leu Val Arg Gly Arg Gln Ala Gly Val Cys Phe Gly Asp 
            180                 185                 190         


Ser Gly Ser Pro Leu Val Cys Asn Gly Leu Ile His Gly Ile Ala Ser 
        195                 200                 205             


Phe Val Arg Gly Gly Cys Ala Ser Gly Leu Tyr Pro Asp Ala Phe Ala 
    210                 215                 220                 


Pro Val Ala Gln Phe Val Asn Trp Ile Asp Ser Ile Ile Gln Gly Ser 
225                 230                 235                 240 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
                245                 250                 255     


Asn Pro Gly Pro Met Arg Leu Thr Val Leu Cys Ala Val Cys Leu Leu 
            260                 265                 270         


Pro Gly Ser Leu Ala Tyr Ser Leu Phe Pro Asn Ser Pro Lys Trp Thr 
        275                 280                 285             


Ser Lys Val Val Thr Tyr Arg Ile Val Ser Tyr Thr Arg Asp Leu Pro 
    290                 295                 300                 


His Ile Thr Val Asp Arg Leu Val Ser Lys Ala Leu Asn Met Trp Gly 
305                 310                 315                 320 


Lys Glu Ile Pro Leu His Phe Arg Lys Val Val Trp Gly Thr Ala Asp 
                325                 330                 335     


Ile Met Ile Gly Phe Ala Arg Gly Ala His Gly Asp Ser Tyr Pro Phe 
            340                 345                 350         


Asp Gly Pro Gly Asn Thr Leu Ala His Ala Phe Ala Pro Gly Thr Gly 
        355                 360                 365             


Leu Gly Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asp Gly 
    370                 375                 380                 


Ser Ser Leu Gly Ile Asn Phe Leu Tyr Ala Ala Thr His Glu Leu Gly 
385                 390                 395                 400 


His Ser Leu Gly Met Gly His Ser Ser Asp Pro Asn Ala Val Met Tyr 
                405                 410                 415     


Pro Thr Tyr Gly Asn Gly Asp Pro Gln Asn Phe Lys Leu Ser Gln Asp 
            420                 425                 430         


Asp Ile Lys Gly Ile Gln Lys Leu Tyr Gly Lys Arg Ser Asn Ser Arg 
        435                 440                 445             


Lys Lys 
    450 


<210>  50
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  50
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

atcgtgggag gcagaagagc cagaccccac gcttggccct tcatggtgtc tctgcagctg      120

agaggcggcc acttctgtgg cgccacactg atcgccccca acttcgtgat gagcgccgcc      180

cactgcgtgg ccaatgtgaa tgtgagagcc gtgagggtgg tgctgggagc ccacaatctg      240

tctaggagag agcctacaag gcaagtgttc gccgtccaga ggatcttcga gaacggctac      300

gaccccgtga atctgctgaa cgacatcgtc attctgcagc tgaacggcag cgctaccatc      360

aacgccaatg tgcaagtggc ccagctgccc gcccaaggca gaagactggg caacggcgtg      420

cagtgtctgg ctatgggatg gggactgctg ggcagaaaca gaggaattgc cagcgtgctc      480

caagagctga acgtgacagt ggtgacatct ctgtgtagaa gaagcaacgt gtgcacactg      540

gtgagaggca gacaagccgg agtgtgcttc ggcgacagcg gcagccctct ggtgtgcaat      600

ggactgatcc acggcatcgc cagcttcgtg agaggaggct gtgccagcgg actgtatccc      660

gacgccttcg cccccgtcgc ccagttcgtc aactggatcg actccatcat ccagggttcc      720

ggagctacca acttttccct cctcaagcaa gccggcgatg tcgaggagaa tcccggaccc      780

atgaggctca cagtgctgtg tgccgtgtgt ctgctgcccg gctctctggc ttactctctg      840

ttccccaaca gccccaagtg gaccagcaaa gtggtgacct atagaatcgt gagctacacc      900

agagatctgc cccacatcac cgtggacaga ctggtgagca aggctctgaa catgtggggc      960

aaggagatcc ctctgcactt taggaaggtg gtgtggggca ccgccgacat catgatcgga     1020

ttcgccagag gcgctcacgg agacagctac cctttcgatg gccccggaaa tacactggcc     1080

cacgcctttg cccccggcac cggactggga ggagatgccc actttgacga ggacgagagg     1140

tggacagacg gctcctctct gggcatcaac tttctgtacg ctgccaccca tgagctggga     1200

cacagcctcg gcatgggaca cagcagcgac cccaacgccg tgatgtaccc tacctatggc     1260

aatggcgatc cccagaactt caagctgtcc caagacgaca tcaagggcat ccagaagctg     1320

tacggaaaga ggtccaactc taggaagaag                                      1350


<210>  51
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  51

Met Trp Gly Leu Lys Val Leu Leu Leu Pro Val Val Ser Phe Ala Arg 
1               5                   10                  15      


Ala Pro Asp Ser Val Asp Tyr Arg Lys Lys Gly Tyr Val Thr Pro Val 
            20                  25                  30          


Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ser Val Gly 
        35                  40                  45              


Ala Leu Glu Gly Gln Leu Lys Lys Lys Thr Gly Lys Leu Leu Asn Leu 
    50                  55                  60                  


Ser Pro Gln Asn Leu Val Asp Cys Val Ser Glu Asn Asp Gly Cys Gly 
65                  70                  75                  80  


Gly Gly Tyr Met Thr Asn Ala Phe Gln Tyr Val Gln Lys Asn Arg Gly 
                85                  90                  95      


Ile Asp Ser Glu Asp Ala Tyr Pro Tyr Val Gly Gln Glu Glu Ser Cys 
            100                 105                 110         


Met Tyr Asn Pro Thr Gly Lys Ala Ala Lys Cys Arg Gly Tyr Arg Glu 
        115                 120                 125             


Ile Pro Glu Gly Asn Glu Lys Ala Leu Lys Arg Ala Val Ala Arg Val 
    130                 135                 140                 


Gly Pro Val Ser Val Ala Ile Asp Ala Ser Leu Thr Ser Phe Gln Phe 
145                 150                 155                 160 


Tyr Ser Lys Gly Val Tyr Tyr Asp Glu Ser Cys Asn Ser Asp Asn Leu 
                165                 170                 175     


Asn His Ala Val Leu Ala Val Gly Tyr Gly Ile Gln Lys Gly Asn Lys 
            180                 185                 190         


His Trp Ile Ile Lys Asn Ser Trp Gly Glu Asn Trp Gly Asn Lys Gly 
        195                 200                 205             


Tyr Ile Leu Met Ala Arg Asn Lys Asn Asn Ala Cys Gly Ile Ala Asn 
    210                 215                 220                 


Leu Ala Ser Phe Pro Lys Met Gly Ser Gly Ala Thr Asn Phe Ser Leu 
225                 230                 235                 240 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Tyr Arg 
                245                 250                 255     


Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val Thr Asn 
            260                 265                 270         


Ser Ile Val Gly Gly Arg Arg Ala Arg Pro His Ala Trp Pro Phe Met 
        275                 280                 285             


Val Ser Leu Gln Leu Arg Gly Gly His Phe Cys Gly Ala Thr Leu Ile 
    290                 295                 300                 


Ala Pro Asn Phe Val Met Ser Ala Ala His Cys Val Ala Asn Val Asn 
305                 310                 315                 320 


Val Arg Ala Val Arg Val Val Leu Gly Ala His Asn Leu Ser Arg Arg 
                325                 330                 335     


Glu Pro Thr Arg Gln Val Phe Ala Val Gln Arg Ile Phe Glu Asn Gly 
            340                 345                 350         


Tyr Asp Pro Val Asn Leu Leu Asn Asp Ile Val Ile Leu Gln Leu Asn 
        355                 360                 365             


Gly Ser Ala Thr Ile Asn Ala Asn Val Gln Val Ala Gln Leu Pro Ala 
    370                 375                 380                 


Gln Gly Arg Arg Leu Gly Asn Gly Val Gln Cys Leu Ala Met Gly Trp 
385                 390                 395                 400 


Gly Leu Leu Gly Arg Asn Arg Gly Ile Ala Ser Val Leu Gln Glu Leu 
                405                 410                 415     


Asn Val Thr Val Val Thr Ser Leu Cys Arg Arg Ser Asn Val Cys Thr 
            420                 425                 430         


Leu Val Arg Gly Arg Gln Ala Gly Val Cys Phe Gly Asp Ser Gly Ser 
        435                 440                 445             


Pro Leu Val Cys Asn Gly Leu Ile His Gly Ile Ala Ser Phe Val Arg 
    450                 455                 460                 


Gly Gly Cys Ala Ser Gly Leu Tyr Pro Asp Ala Phe Ala Pro Val Ala 
465                 470                 475                 480 


Gln Phe Val Asn Trp Ile Asp Ser Ile Ile Gln 
                485                 490     


<210>  52
<211>  1869
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  52
tcgaggtcga cggtatcgat aagcttgata tcgaattagg aggaaaaact gtttcataca       60

gaaggcgtca attaggagga aaaactgttt catacagaag gcgtcaatta ggaggaaaaa      120

ctgtttcata cagaaggcgt caattggtcc catcgaatta ggaggaaaaa ctgtttcata      180

cagaaggcgt caattaggag gaaaaactgt ttcatacaga aggcgtcaat taggaggaaa      240

aactgtttca tacagaaggc gtcaattggt cccgggacat tttgacaccc ccataatatt      300

tttccagaat taacagtata aattgcatct cttgttcaag agttccctat cactctcttt      360

aatcactact cacagtaacc tcaactcctg gccaccatgt ggggactgaa ggtgctgctg      420

ctgcccgtgg tgagctttgc cagagccccc gacagcgtgg actatagaaa gaagggctac      480

gtcacccccg tgaagaatca aggccagtgc ggcagctgct gggcctttag ctccgtgggc      540

gctctggagg gacagctgaa gaagaagacc ggcaagctgc tcaatctgag cccccaaaac      600

ctcgtggact gcgtgagcga gaatgatggc tgtggaggcg gctatatgac caacgccttc      660

cagtacgtgc agaagaatag aggcatcgac agcgaagacg cctaccccta cgtgggccaa      720

gaggagagct gcatgtacaa tcccaccggc aaggctgcca aatgtagagg ctacagagag      780

atccccgagg gcaacgagaa ggctctgaag agggctgtcg ctagggtggg acccgtgagc      840

gtcgccatcg atgcctctct gacaagcttc cagttctaca gcaagggcgt gtactacgac      900

gagagctgca acagcgacaa tctgaaccac gccgtgctcg ctgtgggata cggcatccag      960

aagggcaaca agcactggat catcaagaac agctggggcg agaactgggg caacaagggc     1020

tacattctga tggctagaaa caagaacaac gcttgcggca tcgccaatct ggccagcttc     1080

cccaagatgg gttccggagc taccaacttt tccctcctca agcaagccgg cgatgtcgag     1140

gagaatcccg gacccatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca     1200

cttgtcacga attcgatcgt gggaggcaga agagccagac cccacgcttg gcccttcatg     1260

gtgtctctgc agctgagagg cggccacttc tgtggcgcca cactgatcgc ccccaacttc     1320

gtgatgagcg ccgcccactg cgtggccaat gtgaatgtga gagccgtgag ggtggtgctg     1380

ggagcccaca atctgtctag gagagagcct acaaggcaag tgttcgccgt ccagaggatc     1440

ttcgagaacg gctacgaccc cgtgaatctg ctgaacgaca tcgtcattct gcagctgaac     1500

ggcagcgcta ccatcaacgc caatgtgcaa gtggcccagc tgcccgccca aggcagaaga     1560

ctgggcaacg gcgtgcagtg tctggctatg ggatggggac tgctgggcag aaacagagga     1620

attgccagcg tgctccaaga gctgaacgtg acagtggtga catctctgtg tagaagaagc     1680

aacgtgtgca cactggtgag aggcagacaa gccggagtgt gcttcggcga cagcggcagc     1740

cctctggtgt gcaatggact gatccacggc atcgccagct tcgtgagagg aggctgtgcc     1800

agcggactgt atcccgacgc cttcgccccc gtcgcccagt tcgtcaactg gatcgactcc     1860

atcatccag                                                             1869


<210>  53
<211>  703
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  53

Met Trp Gly Leu Lys Val Leu Leu Leu Pro Val Val Ser Phe Ala Arg 
1               5                   10                  15      


Ala Pro Asp Ser Val Asp Tyr Arg Lys Lys Gly Tyr Val Thr Pro Val 
            20                  25                  30          


Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ser Val Gly 
        35                  40                  45              


Ala Leu Glu Gly Gln Leu Lys Lys Lys Thr Gly Lys Leu Leu Asn Leu 
    50                  55                  60                  


Ser Pro Gln Asn Leu Val Asp Cys Val Ser Glu Asn Asp Gly Cys Gly 
65                  70                  75                  80  


Gly Gly Tyr Met Thr Asn Ala Phe Gln Tyr Val Gln Lys Asn Arg Gly 
                85                  90                  95      


Ile Asp Ser Glu Asp Ala Tyr Pro Tyr Val Gly Gln Glu Glu Ser Cys 
            100                 105                 110         


Met Tyr Asn Pro Thr Gly Lys Ala Ala Lys Cys Arg Gly Tyr Arg Glu 
        115                 120                 125             


Ile Pro Glu Gly Asn Glu Lys Ala Leu Lys Arg Ala Val Ala Arg Val 
    130                 135                 140                 


Gly Pro Val Ser Val Ala Ile Asp Ala Ser Leu Thr Ser Phe Gln Phe 
145                 150                 155                 160 


Tyr Ser Lys Gly Val Tyr Tyr Asp Glu Ser Cys Asn Ser Asp Asn Leu 
                165                 170                 175     


Asn His Ala Val Leu Ala Val Gly Tyr Gly Ile Gln Lys Gly Asn Lys 
            180                 185                 190         


His Trp Ile Ile Lys Asn Ser Trp Gly Glu Asn Trp Gly Asn Lys Gly 
        195                 200                 205             


Tyr Ile Leu Met Ala Arg Asn Lys Asn Asn Ala Cys Gly Ile Ala Asn 
    210                 215                 220                 


Leu Ala Ser Phe Pro Lys Met Gly Ser Gly Ala Thr Asn Phe Ser Leu 
225                 230                 235                 240 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Tyr Arg 
                245                 250                 255     


Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val Thr Asn 
            260                 265                 270         


Ser Ile Val Gly Gly Arg Arg Ala Arg Pro His Ala Trp Pro Phe Met 
        275                 280                 285             


Val Ser Leu Gln Leu Arg Gly Gly His Phe Cys Gly Ala Thr Leu Ile 
    290                 295                 300                 


Ala Pro Asn Phe Val Met Ser Ala Ala His Cys Val Ala Asn Val Asn 
305                 310                 315                 320 


Val Arg Ala Val Arg Val Val Leu Gly Ala His Asn Leu Ser Arg Arg 
                325                 330                 335     


Glu Pro Thr Arg Gln Val Phe Ala Val Gln Arg Ile Phe Glu Asn Gly 
            340                 345                 350         


Tyr Asp Pro Val Asn Leu Leu Asn Asp Ile Val Ile Leu Gln Leu Asn 
        355                 360                 365             


Gly Ser Ala Thr Ile Asn Ala Asn Val Gln Val Ala Gln Leu Pro Ala 
    370                 375                 380                 


Gln Gly Arg Arg Leu Gly Asn Gly Val Gln Cys Leu Ala Met Gly Trp 
385                 390                 395                 400 


Gly Leu Leu Gly Arg Asn Arg Gly Ile Ala Ser Val Leu Gln Glu Leu 
                405                 410                 415     


Asn Val Thr Val Val Thr Ser Leu Cys Arg Arg Ser Asn Val Cys Thr 
            420                 425                 430         


Leu Val Arg Gly Arg Gln Ala Gly Val Cys Phe Gly Asp Ser Gly Ser 
        435                 440                 445             


Pro Leu Val Cys Asn Gly Leu Ile His Gly Ile Ala Ser Phe Val Arg 
    450                 455                 460                 


Gly Gly Cys Ala Ser Gly Leu Tyr Pro Asp Ala Phe Ala Pro Val Ala 
465                 470                 475                 480 


Gln Phe Val Asn Trp Ile Asp Ser Ile Ile Gln Gly Ser Gly Ala Thr 
                485                 490                 495     


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
            500                 505                 510         


Pro Met Arg Leu Thr Val Leu Cys Ala Val Cys Leu Leu Pro Gly Ser 
        515                 520                 525             


Leu Ala Tyr Ser Leu Phe Pro Asn Ser Pro Lys Trp Thr Ser Lys Val 
    530                 535                 540                 


Val Thr Tyr Arg Ile Val Ser Tyr Thr Arg Asp Leu Pro His Ile Thr 
545                 550                 555                 560 


Val Asp Arg Leu Val Ser Lys Ala Leu Asn Met Trp Gly Lys Glu Ile 
                565                 570                 575     


Pro Leu His Phe Arg Lys Val Val Trp Gly Thr Ala Asp Ile Met Ile 
            580                 585                 590         


Gly Phe Ala Arg Gly Ala His Gly Asp Ser Tyr Pro Phe Asp Gly Pro 
        595                 600                 605             


Gly Asn Thr Leu Ala His Ala Phe Ala Pro Gly Thr Gly Leu Gly Gly 
    610                 615                 620                 


Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asp Gly Ser Ser Leu 
625                 630                 635                 640 


Gly Ile Asn Phe Leu Tyr Ala Ala Thr His Glu Leu Gly His Ser Leu 
                645                 650                 655     


Gly Met Gly His Ser Ser Asp Pro Asn Ala Val Met Tyr Pro Thr Tyr 
            660                 665                 670         


Gly Asn Gly Asp Pro Gln Asn Phe Lys Leu Ser Gln Asp Asp Ile Lys 
        675                 680                 685             


Gly Ile Gln Lys Leu Tyr Gly Lys Arg Ser Asn Ser Arg Lys Lys 
    690                 695                 700             


<210>  54
<211>  2505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  54
tcgaggtcga cggtatcgat aagcttgata tcgaattagg aggaaaaact gtttcataca       60

gaaggcgtca attaggagga aaaactgttt catacagaag gcgtcaatta ggaggaaaaa      120

ctgtttcata cagaaggcgt caattggtcc catcgaatta ggaggaaaaa ctgtttcata      180

cagaaggcgt caattaggag gaaaaactgt ttcatacaga aggcgtcaat taggaggaaa      240

aactgtttca tacagaaggc gtcaattggt cccgggacat tttgacaccc ccataatatt      300

tttccagaat taacagtata aattgcatct cttgttcaag agttccctat cactctcttt      360

aatcactact cacagtaacc tcaactcctg gccaccatgt ggggactgaa ggtgctgctg      420

ctgcccgtgg tgagctttgc cagagccccc gacagcgtgg actatagaaa gaagggctac      480

gtcacccccg tgaagaatca aggccagtgc ggcagctgct gggcctttag ctccgtgggc      540

gctctggagg gacagctgaa gaagaagacc ggcaagctgc tcaatctgag cccccaaaac      600

ctcgtggact gcgtgagcga gaatgatggc tgtggaggcg gctatatgac caacgccttc      660

cagtacgtgc agaagaatag aggcatcgac agcgaagacg cctaccccta cgtgggccaa      720

gaggagagct gcatgtacaa tcccaccggc aaggctgcca aatgtagagg ctacagagag      780

atccccgagg gcaacgagaa ggctctgaag agggctgtcg ctagggtggg acccgtgagc      840

gtcgccatcg atgcctctct gacaagcttc cagttctaca gcaagggcgt gtactacgac      900

gagagctgca acagcgacaa tctgaaccac gccgtgctcg ctgtgggata cggcatccag      960

aagggcaaca agcactggat catcaagaac agctggggcg agaactgggg caacaagggc     1020

tacattctga tggctagaaa caagaacaac gcttgcggca tcgccaatct ggccagcttc     1080

cccaagatgg gttccggagc taccaacttt tccctcctca agcaagccgg cgatgtcgag     1140

gagaatcccg gacccatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca     1200

cttgtcacga attcgatcgt gggaggcaga agagccagac cccacgcttg gcccttcatg     1260

gtgtctctgc agctgagagg cggccacttc tgtggcgcca cactgatcgc ccccaacttc     1320

gtgatgagcg ccgcccactg cgtggccaat gtgaatgtga gagccgtgag ggtggtgctg     1380

ggagcccaca atctgtctag gagagagcct acaaggcaag tgttcgccgt ccagaggatc     1440

ttcgagaacg gctacgaccc cgtgaatctg ctgaacgaca tcgtcattct gcagctgaac     1500

ggcagcgcta ccatcaacgc caatgtgcaa gtggcccagc tgcccgccca aggcagaaga     1560

ctgggcaacg gcgtgcagtg tctggctatg ggatggggac tgctgggcag aaacagagga     1620

attgccagcg tgctccaaga gctgaacgtg acagtggtga catctctgtg tagaagaagc     1680

aacgtgtgca cactggtgag aggcagacaa gccggagtgt gcttcggcga cagcggcagc     1740

cctctggtgt gcaatggact gatccacggc atcgccagct tcgtgagagg aggctgtgcc     1800

agcggactgt atcccgacgc cttcgccccc gtcgcccagt tcgtcaactg gatcgactcc     1860

atcatccagg gttccggagc taccaacttt tccctcctca agcaagccgg cgatgtcgag     1920

gagaatcccg gacccatgag gctcacagtg ctgtgtgccg tgtgtctgct gcccggctct     1980

ctggcttact ctctgttccc caacagcccc aagtggacca gcaaagtggt gacctataga     2040

atcgtgagct acaccagaga tctgccccac atcaccgtgg acagactggt gagcaaggct     2100

ctgaacatgt ggggcaagga gatccctctg cactttagga aggtggtgtg gggcaccgcc     2160

gacatcatga tcggattcgc cagaggcgct cacggagaca gctacccttt cgatggcccc     2220

ggaaatacac tggcccacgc ctttgccccc ggcaccggac tgggaggaga tgcccacttt     2280

gacgaggacg agaggtggac agacggctcc tctctgggca tcaactttct gtacgctgcc     2340

acccatgagc tgggacacag cctcggcatg ggacacagca gcgaccccaa cgccgtgatg     2400

taccctacct atggcaatgg cgatccccag aacttcaagc tgtcccaaga cgacatcaag     2460

ggcatccaga agctgtacgg aaagaggtcc aactctagga agaag                     2505


<210>  55
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  55

Leu Asp Leu Glu Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe 
1               5                   10                  15      


Gln Leu Leu Asp Leu Glu Met Leu Ala Pro Tyr Ile Pro Met Asp Asp 
            20                  25                  30          


Asp Phe Gln Leu Leu Asp Leu Glu Met Leu Ala Pro Tyr Ile Pro Met 
        35                  40                  45              


Asp Asp Asp Phe Gln Leu 
    50                  


<210>  56
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  56

Leu Asp Leu Glu Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe 
1               5                   10                  15      


Gln Leu Leu Asp Leu Glu Met Leu Ala Pro Tyr Ile Pro Met Asp Asp 
            20                  25                  30          


Asp Phe Gln Leu 
        35      


<210>  57
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  57

Leu Asp Leu Glu Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe 
1               5                   10                  15      


Gln Leu 
        


