                         SEQUENCE LISTING

<110>  ELEMENT BIOSCIENCES, INC.
 
<120>  ENGINEERED POLYMERASES

<130>  38119-52269/WO

<150>  63/212,540
<151>  2021-06-18

<150>  17/705,011
<151>  2022-03-25

<150>  17/705,020
<151>  2022-03-25

<150>  17/705,043
<151>  2022-03-25

<160>  399   

<170>  PatentIn version 3.5

<210>  1
<211>  773
<212>  PRT
<213>  Unknown

<220>
<223>  Description of Unknown: Candidatus Altiarchaeales archaeon 
       sequence

<400>  1

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Asp Met Glu Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  2
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  2

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Leu Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  3
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  3

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Ser Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  4
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  4

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Ile Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  5
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  5

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Thr 
                405                 410                 415     


Gly Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  6
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  6

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Asn Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  7
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  7

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Ala Ser Leu Lys Ser 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  8
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  8

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Asn 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  9
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  9

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Gly Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Val Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  10
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  10

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Thr Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  11
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  11

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ala Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  12
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  12

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Gly 
                405                 410                 415     


Thr Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  13
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  13

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ala Leu 
                405                 410                 415     


Tyr Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  14
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  14

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asn Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Gln Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  15
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  15

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Arg Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  16
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  16

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  17
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  17

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Val Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  18
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  18

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Ile Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asp Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  19
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  19

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Gly 
                405                 410                 415     


Gly Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  20
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  20

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ile Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  21
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  21

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Val 
                405                 410                 415     


Gly Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  22
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  22

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Val Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  23
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  23

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Ala Leu 
                485                 490                 495     


Leu Ala Ala Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  24
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  24

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Tyr Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  25
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  25

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro His Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Gly 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  26
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  26

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Gly Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  27
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  27

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  28
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  28

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Gly Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  29
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  29

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Ala Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Ala 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  30
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  30

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Thr 
                405                 410                 415     


Gly Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  31
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  31

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Ser Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  32
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  32

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Arg Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  33
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  33

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Ala Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  34
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  34

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Leu Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  35
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  35

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Val Ser 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  36
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  36

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Ser 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  37
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  37

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Gly Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  38
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  38

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Gly Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  39
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  39

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Ala Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  40
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  40

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Val Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Gly Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  41
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  41

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  42
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  42

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Gly Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  43
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  43

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Val 
                405                 410                 415     


Tyr Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  44
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  44

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Gly Leu 
                405                 410                 415     


Ser Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  45
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  45

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Gly 
                405                 410                 415     


Ala Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  46
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  46

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Gly Leu 
                485                 490                 495     


Leu Ala Ala Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  47
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  47

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Ser Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  48
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  48

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ile 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Phe Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  49
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  49

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Val 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  50
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  50

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Val 
                405                 410                 415     


Ala Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  51
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  51

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Gln Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Arg Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  52
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  52

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His His 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Phe Gly Tyr Phe Gly Ser Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Ile Val Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Asn Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  53
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  53

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu His Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Arg Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  54
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  54

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Cys 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  55
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  55

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Ile Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  56
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  56

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Gly Leu 
                405                 410                 415     


Tyr Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  57
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  57

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Gly Leu 
                405                 410                 415     


Val Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  58
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  58

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Val 
                405                 410                 415     


Ala Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  59
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  59

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Gly Cys Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  60
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  60

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Ala Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  61
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  61

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Cys Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Gly Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Ala Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  62
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  62

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Cys Ser Leu Lys Arg 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  63
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  63

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys His 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  64
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  64

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Pro Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  65
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  65

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Gly Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  66
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  66

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Ala Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  67
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  67

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Gly Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  68
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  68

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Ile Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  69
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  69

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile Pro Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Gly Leu 
                485                 490                 495     


Leu Ala Ala Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  70
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  70

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Val 
                405                 410                 415     


Gly Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  71
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  71

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Ser Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  72
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  72

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  73
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  73

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Leu Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  74
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  74

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Ala Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  75
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  75

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Val 
                405                 410                 415     


Tyr Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  76
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  76

Met Lys Lys Thr Leu Leu Asp Ala Asp Phe Ile Thr Arg Lys Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu Arg 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asn Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Val Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Val Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Val Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Ser Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Asp Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asp Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  77
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  77

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Ser Val Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Arg Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  78
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  78

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Val Leu 
                405                 410                 415     


Tyr Val Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  79
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  79

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Lys 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  80
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  80

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Ile Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Ala Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  81
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  81

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Val Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Gly Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn His Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  82
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  82

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Ser Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  83
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  83

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Gln Leu 
                485                 490                 495     


Leu Ala Gly Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  84
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  84

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Val Leu 
                485                 490                 495     


Leu Ala Ala Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  85
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  85

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  86
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  86

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Glu Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  87
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  87

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Ser Leu 
                485                 490                 495     


Leu Ala Val Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  88
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  88

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Gly Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Val Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  89
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  89

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Met 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  90
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  90

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Gly Val 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  91
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  91

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Arg Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  92
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  92

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gly Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  93
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  93

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Val Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  94
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  94

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Gly Val Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  95
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  95

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Ile 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Ala Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  96
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  96

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Gly Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  97
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  97

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Lys 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  98
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  98

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Val Leu 
                405                 410                 415     


Ser Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  99
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  99

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Ser Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Arg Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  100
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  100

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Ser Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  101
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  101

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Gly Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  102
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  102

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asn Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  103
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  103

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Ile Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asp Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  104
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  104

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Gly Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  105
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  105

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Thr Ser Leu Lys Ser 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  106
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  106

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Gly Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  107
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  107

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Lys Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Glu Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  108
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  108

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Gly Ser 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  109
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  109

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Ile Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Ser Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  110
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  110

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  111
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  111

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Ser Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  112
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  112

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Gln Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  113
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  113

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Ile Lys Gln Arg Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  114
<211>  767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  114

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Val Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Val Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Val Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln 
        755                 760                 765         


<210>  115
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  115

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Val 
                405                 410                 415     


Val Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  116
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  116

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Gly Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Asn Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  117
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  117

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Lys Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu Arg 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asn Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Val Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Val Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Val Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Val Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Ile Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Ser Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Ile Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asp Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  118
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  118

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Gly Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  119
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  119

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Arg Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  120
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  120

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Ser Leu 
                485                 490                 495     


Leu Ala Gly Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  121
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  121

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Ala Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  122
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  122

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Val 
                405                 410                 415     


Thr Ile Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  123
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  123

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Ser Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  124
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  124

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Val Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  125
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  125

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Val Leu 
                405                 410                 415     


Tyr Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  126
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  126

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Ile Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala His 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  127
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  127

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ala Ser 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  128
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  128

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ile 
                405                 410                 415     


Ala Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Leu Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  129
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  129

Met Lys Lys Thr Leu Leu Asp Ala Asp Phe Ile Thr Arg Lys Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu Arg 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asn Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Val Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Val Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Val Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Asp Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asp Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  130
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  130

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Ala Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  131
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  131

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Ala Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Arg Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  132
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  132

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Ser Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Asn Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  133
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  133

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Val 
                405                 410                 415     


Ala Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  134
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  134

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Val Leu 
                485                 490                 495     


Leu Ala Gly Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  135
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  135

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Arg 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  136
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  136

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Arg Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  137
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  137

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Gly Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  138
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  138

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Val 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Thr Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  139
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  139

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ile 
                405                 410                 415     


Ala Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  140
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  140

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Gly Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  141
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  141

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Val Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  142
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  142

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ala Leu 
                405                 410                 415     


Gly Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  143
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  143

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Val 
                405                 410                 415     


Thr Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  144
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  144

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Gly Leu 
                405                 410                 415     


Tyr Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  145
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  145

Met Lys Lys Thr Leu Leu Asp Ala Asn Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  146
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  146

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Gly Leu 
                485                 490                 495     


Leu Ala Ser Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  147
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  147

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Ile 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  148
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  148

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Val Leu 
                405                 410                 415     


Ala Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  149
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  149

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Tyr Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  150
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  150

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  151
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  151

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Tyr 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  152
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  152

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Gly Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  153
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  153

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Gly Ala 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  154
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  154

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Val 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ser Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  155
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  155

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Ser Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  156
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  156

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Ser Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  157
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  157

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Val Leu 
                405                 410                 415     


Ala Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Gly Leu 
                485                 490                 495     


Leu Ala Ser Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  158
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  158

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Tyr Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  159
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  159

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Ser Leu 
                485                 490                 495     


Leu Ala Gly Ser Met Tyr Gly Tyr Phe Gly Ser Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  160
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  160

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Tyr Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  161
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  161

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Arg Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  162
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  162

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Ser 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  163
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  163

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Val Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  164
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  164

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  165
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  165

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Gly Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  166
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  166

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu Arg 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  167
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  167

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Gly Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  168
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  168

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gly Ser Leu Lys Ile 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  169
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  169

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Thr Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  170
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  170

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Thr Lys Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  171
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  171

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Thr Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  172
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  172

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Gly 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  173
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  173

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Val 
                405                 410                 415     


Gly Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  174
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  174

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Leu Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  175
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  175

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Val 
                405                 410                 415     


Gly Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  176
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  176

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Ser Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Ser Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  177
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  177

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Thr 
                405                 410                 415     


Ala Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  178
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  178

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ile 
                405                 410                 415     


Ser Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  179
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  179

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Gly Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  180
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  180

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Arg Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  181
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  181

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Ile Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  182
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  182

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Leu Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Ser Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  183
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  183

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Asp Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  184
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  184

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Val Lys Asn 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  185
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  185

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ser Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  186
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  186

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Tyr Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  187
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  187

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Gly Leu 
                485                 490                 495     


Leu Ala Val Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  188
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  188

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Arg Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  189
<211>  767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  189

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Arg Val Trp Ala Ser Lys 
        755                 760                 765         


<210>  190
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  190

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Gly 
                405                 410                 415     


Tyr Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  191
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  191

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ile 
                405                 410                 415     


Ala Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  192
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  192

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Asn Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Phe Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  193
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  193

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  194
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  194

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Met Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  195
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  195

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Ala 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  196
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  196

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Ile Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  197
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  197

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Ile Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asp Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  198
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  198

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Ala Ile Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  199
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  199

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Gly Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Asp Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Gly Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Val Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  200
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  200

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Val 
                405                 410                 415     


Gly Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  201
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  201

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Phe Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  202
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  202

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Arg Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  203
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  203

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Gly Leu 
                485                 490                 495     


Leu Ala Gly Ser Ile Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  204
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  204

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Pro Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  205
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  205

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Met Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  206
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  206

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Val Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  207
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  207

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Tyr 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  208
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  208

Met Lys Lys Thr Leu Leu Asp Ala Asp Phe Ile Thr Arg Lys Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu Arg 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asn Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Val Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Val Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Val Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Tyr 
                405                 410                 415     


Ala Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Ser Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Asp Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asp Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  209
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  209

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Leu Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Ile Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  210
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  210

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro His Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Asn Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Lys Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  211
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  211

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Gly 
                405                 410                 415     


Tyr Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  212
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  212

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Ile Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  213
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  213

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Tyr Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  214
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  214

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asn Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  215
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  215

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Ile Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  216
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  216

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Val Val Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Ser Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  217
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  217

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg His Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  218
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  218

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Gly Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  219
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  219

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Ala Val Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  220
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  220

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Arg Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  221
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  221

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Ala 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  222
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  222

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Leu Ser Leu Lys Met 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  223
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  223

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Ser Leu 
                485                 490                 495     


Leu Ala Gly Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  224
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  224

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Ser Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  225
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  225

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  226
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  226

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Val Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Arg Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  227
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  227

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Phe Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  228
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  228

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  229
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  229

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Val Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  230
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  230

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Thr Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  231
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  231

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ala Leu 
                405                 410                 415     


Ala Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  232
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  232

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Val Leu 
                485                 490                 495     


Leu Ala Ser Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  233
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  233

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ile 
                405                 410                 415     


Ala Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  234
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  234

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Arg Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  235
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  235

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Ile Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asp Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Lys Phe Lys Gln Gly 
    690                 695                 700                 


Ser Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  236
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  236

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Ser Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  237
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  237

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile Pro Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Val Leu 
                485                 490                 495     


Leu Ala Ala Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  238
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  238

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ile 
                405                 410                 415     


Gly Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Leu Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  239
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  239

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Arg Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  240
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  240

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Thr Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  241
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  241

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Gly Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  242
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  242

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Val 
                405                 410                 415     


Val Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  243
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  243

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Ala Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  244
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  244

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  245
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  245

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Gly Leu 
                405                 410                 415     


Tyr Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  246
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  246

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Arg Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Ile Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  247
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  247

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Phe Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Arg Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  248
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  248

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Glu Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  249
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  249

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Ala Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Arg Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  250
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  250

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ile 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  251
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  251

Met Lys Lys Thr Leu Leu Asp Ala Asp Phe Ile Thr Arg Lys Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu Arg 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asn Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Val Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Val Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Val Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Ser Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Asp Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asp Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  252
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  252

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Ser Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  253
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  253

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Arg Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  254
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  254

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Lys Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  255
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  255

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Gly Leu 
                485                 490                 495     


Leu Ala Gly Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  256
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  256

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Glu Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  257
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  257

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Ile Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asp Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Lys Phe Lys Gln Gly 
    690                 695                 700                 


Asp Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  258

<400>  258
000

<210>  259

<400>  259
000

<210>  260

<400>  260
000

<210>  261

<400>  261
000

<210>  262

<400>  262
000

<210>  263

<400>  263
000

<210>  264

<400>  264
000

<210>  265

<400>  265
000

<210>  266

<400>  266
000

<210>  267

<400>  267
000

<210>  268

<400>  268
000

<210>  269
<211>  135
<212>  PRT
<213>  Unknown

<220>
<223>  Description of Unknown: Candidatus Altiarchaeales archaeon 
       sequence

<400>  269

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu 
    130                 135 


<210>  270
<211>  212
<212>  PRT
<213>  Unknown

<220>
<223>  Description of Unknown: Candidatus Altiarchaeales archaeon 
       sequence

<400>  270

Arg Ile Ala Ala Phe Asp Met Glu Val Tyr Asn Pro Arg Gly Glu Pro 
1               5                   10                  15      


Lys Ala Glu Arg Asp Pro Ile Ile Ile Ile Ser Tyr Ala Asp Asn Arg 
            20                  25                  30          


Gly Leu Arg Arg Val Trp Thr Tyr Lys Thr Val Glu Asn Leu Asn Leu 
        35                  40                  45              


Asp Tyr Met Glu Val Leu Lys Asp Glu Arg Glu Ile Ile Arg Arg Phe 
    50                  55                  60                  


Ile Asp Thr Ile Arg Glu Arg Glu Ile Asp Ile Ile Val Thr Tyr Asn 
65                  70                  75                  80  


Gly Asp Asn Phe Asp Phe Pro Tyr Leu Lys Glu Arg Ala Glu Lys His 
                85                  90                  95      


Arg Ile Pro Val Ser Leu Gly Val Asp Gly Ser Pro Leu Arg Leu Glu 
            100                 105                 110         


Arg Arg Gly Met Asn Leu Gly Ala Arg Val Thr Gly Arg Pro His Ile 
        115                 120                 125             


Asp Met Tyr Pro Val Cys Arg Gln Ile Phe Asn Leu Ser Arg Tyr Thr 
    130                 135                 140                 


Leu Glu Asp Val Tyr Leu Glu Ile Thr Gly Arg Glu Lys Lys Asp Ile 
145                 150                 155                 160 


Arg Val Gly Glu Met Ala Gly Ile Trp Asp Asn Pro Glu Lys Glu Lys 
                165                 170                 175     


Phe Lys Glu Leu Ile Glu Tyr Ala Met Ser Asp Ala Glu Ser Thr Leu 
            180                 185                 190         


Glu Ile Ala Ile Thr Leu Leu Pro Leu His Tyr Glu Ile Ser Arg Ile 
        195                 200                 205             


Thr Arg Glu Leu 
    210         


<210>  271
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  Description of Unknown: Candidatus Altiarchaeales archaeon 
       sequence

<400>  271

Ile Tyr Gln Ser Ser Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu 
1               5                   10                  15      


Leu Ile Lys Lys Ala Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro 
            20                  25                  30          


Ser Asp Arg Val Val Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala 
        35                  40                  45              


Tyr Val Val Glu Pro Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe 
    50                  55                  60                  


Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp 
65                  70                  75                  80  


Pro Ser Thr Ile Asp Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser 
                85                  90                  95      


Pro Thr Gly His Tyr Phe Cys Lys Lys Lys Arg 
            100                 105         


<210>  272
<211>  50
<212>  PRT
<213>  Unknown

<220>
<223>  Description of Unknown: Candidatus Altiarchaeales archaeon 
       sequence

<400>  272

Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu Val Gln Arg Arg Ile Glu 
1               5                   10                  15      


Val Lys Lys Gly Leu Lys Asn Glu Lys Asn Pro Glu Arg Arg Arg Phe 
            20                  25                  30          


Leu Asp Val Lys Gln Gln Ala Leu Lys Leu Leu Ala Asn Ser Met Tyr 
        35                  40                  45              


Gly Tyr 
    50  


<210>  273
<211>  120
<212>  PRT
<213>  Unknown

<220>
<223>  Description of Unknown: Candidatus Altiarchaeales archaeon 
       sequence

<400>  273

Phe Gly Phe Pro Arg Ala Arg Trp Tyr Cys Arg Glu Cys Ala Glu Ser 
1               5                   10                  15      


Ile Thr Ala Leu Gly Arg Lys Tyr Ile Leu His Thr Ile Asp Ile Val 
            20                  25                  30          


Pro Lys Phe Gly Phe Asp Val Ile Tyr Gly Asp Thr Asp Ser Val Tyr 
        35                  40                  45              


Leu Ile Lys Pro Asn Ile Thr Asp Arg Glu Arg Val Met Lys Asn Ala 
    50                  55                  60                  


Glu His Phe Leu Asp Lys Ile Asn Ser Glu Leu Pro Glu Ala Met Glu 
65                  70                  75                  80  


Leu Glu Phe Glu Gly Phe Tyr Pro Arg Gly Ile Phe Ile Thr Lys Lys 
                85                  90                  95      


Arg Tyr Ala Leu Ile Asp Glu Arg Gly Lys Leu Ile Val Lys Gly Leu 
            100                 105                 110         


Glu Thr Lys Arg Arg Asp Trp Ala 
        115                 120 


<210>  274
<211>  149
<212>  PRT
<213>  Unknown

<220>
<223>  Description of Unknown: Candidatus Altiarchaeales archaeon 
       sequence

<400>  274

Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
1               5                   10                  15      


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
            20                  25                  30          


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
        35                  40                  45              


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
    50                  55                  60                  


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
65                  70                  75                  80  


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
                85                  90                  95      


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
            100                 105                 110         


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
        115                 120                 125             


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
    130                 135                 140                 


Lys Leu Gly Gly Phe 
145                 


<210>  275
<211>  876
<212>  PRT
<213>  Geobacillus stearothermophilus

<400>  275

Met Lys Lys Lys Leu Val Leu Ile Asp Gly Asn Ser Val Ala Tyr Arg 
1               5                   10                  15      


Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 
            20                  25                  30          


Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 
        35                  40                  45              


Glu Gln Pro Thr His Leu Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 
    50                  55                  60                  


Phe Arg His Glu Thr Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 
65                  70                  75                  80  


Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Lys 
                85                  90                  95      


Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Asp His Tyr Glu Ala Asp Asp 
            100                 105                 110         


Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 
        115                 120                 125             


Lys Ile Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Arg His 
    130                 135                 140                 


Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 
145                 150                 155                 160 


Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 
                165                 170                 175     


Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 
            180                 185                 190         


Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Lys Gln Phe 
        195                 200                 205             


Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Val Lys Gly Glu 
    210                 215                 220                 


Lys Leu Lys Glu Asn Leu Arg Gln His Arg Asp Leu Ala Leu Leu Ser 
225                 230                 235                 240 


Lys Gln Leu Ala Ser Ile Cys Arg Asp Ala Pro Val Glu Leu Ser Leu 
                245                 250                 255     


Asp Asp Ile Val Tyr Glu Gly Gln Asp Arg Glu Lys Val Ile Ala Leu 
            260                 265                 270         


Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Ala Ala Pro 
        275                 280                 285             


Ala Ala Glu Gly Glu Lys Pro Leu Glu Glu Met Glu Phe Ala Ile Val 
    290                 295                 300                 


Asp Val Ile Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 
305                 310                 315                 320 


Glu Val Met Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 
                325                 330                 335     


Leu Val Asn Glu His Gly Arg Phe Phe Met Arg Pro Glu Thr Ala Leu 
            340                 345                 350         


Ala Asp Ser Gln Phe Leu Ala Trp Leu Ala Asp Glu Thr Lys Lys Lys 
        355                 360                 365             


Ser Met Phe Asp Ala Lys Arg Ala Val Val Ala Leu Lys Trp Lys Gly 
    370                 375                 380                 


Ile Glu Leu Arg Gly Val Ala Phe Asp Leu Leu Leu Ala Ala Tyr Leu 
385                 390                 395                 400 


Leu Asn Pro Ala Gln Asp Ala Gly Asp Ile Ala Ala Val Ala Lys Met 
                405                 410                 415     


Lys Gln Tyr Glu Ala Val Arg Ser Asp Glu Ala Val Tyr Gly Lys Gly 
            420                 425                 430         


Val Lys Arg Ser Leu Pro Asp Glu Gln Thr Leu Ala Glu His Leu Val 
        435                 440                 445             


Arg Lys Ala Ala Ala Ile Trp Ala Leu Glu Gln Pro Phe Met Asp Asp 
    450                 455                 460                 


Leu Arg Asn Asn Glu Gln Asp Gln Leu Leu Thr Lys Leu Glu Gln Pro 
465                 470                 475                 480 


Leu Ala Ala Ile Leu Ala Glu Met Glu Phe Thr Gly Val Asn Val Asp 
                485                 490                 495     


Thr Lys Arg Leu Glu Gln Met Gly Ser Glu Leu Ala Glu Gln Leu Arg 
            500                 505                 510         


Ala Ile Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 
        515                 520                 525             


Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 
    530                 535                 540                 


Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 
545                 550                 555                 560 


Leu Glu Lys Leu Ala Pro His His Glu Ile Val Glu Asn Ile Leu His 
                565                 570                 575     


Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 
            580                 585                 590         


Lys Val Val Arg Pro Asp Thr Gly Lys Val His Thr Met Phe Asn Gln 
        595                 600                 605             


Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Ala Glu Pro Asn Leu Gln 
    610                 615                 620                 


Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 
625                 630                 635                 640 


Val Pro Ser Glu Pro Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 
                645                 650                 655     


Ile Glu Leu Arg Val Leu Ala His Ile Ala Asp Asp Asp Asn Leu Ile 
            660                 665                 670         


Glu Ala Phe Gln Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 
        675                 680                 685             


Ile Phe His Val Ser Glu Glu Glu Val Thr Ala Asn Met Arg Arg Gln 
    690                 695                 700                 


Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Asp Tyr Gly 
705                 710                 715                 720 


Leu Ala Gln Asn Leu Asn Ile Thr Arg Lys Glu Ala Ala Glu Phe Ile 
                725                 730                 735     


Glu Arg Tyr Phe Ala Ser Phe Pro Gly Val Lys Gln Tyr Met Glu Asn 
            740                 745                 750         


Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 
        755                 760                 765             


Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Asn Val Arg 
    770                 775                 780                 


Ser Phe Ala Glu Arg Thr Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 
785                 790                 795                 800 


Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Ala Ala Arg Leu Lys 
                805                 810                 815     


Glu Glu Gln Leu Gln Ala Arg Leu Leu Leu Gln Val His Asp Glu Leu 
            820                 825                 830         


Ile Leu Glu Ala Pro Lys Glu Glu Ile Glu Arg Leu Cys Glu Leu Val 
        835                 840                 845             


Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 
    850                 855                 860                 


Asp Tyr His Tyr Gly Pro Thr Trp Tyr Asp Ala Lys 
865                 870                 875     


<210>  276
<211>  876
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  276

Met Lys Lys Lys Leu Val Leu Ile Asp Gly Asn Ser Val Ala Tyr Arg 
1               5                   10                  15      


Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 
            20                  25                  30          


Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 
        35                  40                  45              


Glu Gln Pro Thr His Leu Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 
    50                  55                  60                  


Phe Arg His Glu Thr Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 
65                  70                  75                  80  


Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Lys 
                85                  90                  95      


Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Asp His Tyr Glu Ala Asp Asp 
            100                 105                 110         


Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 
        115                 120                 125             


Lys Ile Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Arg His 
    130                 135                 140                 


Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 
145                 150                 155                 160 


Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 
                165                 170                 175     


Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 
            180                 185                 190         


Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Lys Gln Phe 
        195                 200                 205             


Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Val Lys Gly Glu 
    210                 215                 220                 


Lys Leu Lys Glu Asn Leu Arg Gln His Arg Asp Leu Ala Leu Leu Ser 
225                 230                 235                 240 


Lys Gln Leu Ala Ser Ile Cys Arg Asp Ala Pro Val Glu Leu Ser Leu 
                245                 250                 255     


Asp Asp Ile Val Tyr Glu Gly Gln Asp Arg Glu Lys Val Ile Ala Leu 
            260                 265                 270         


Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Ala Ala Pro 
        275                 280                 285             


Ala Ala Glu Gly Glu Lys Pro Leu Glu Glu Met Glu Phe Ala Ile Val 
    290                 295                 300                 


Asp Val Ile Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 
305                 310                 315                 320 


Glu Val Met Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 
                325                 330                 335     


Leu Val Asn Glu His Gly Arg Phe Phe Met Arg Pro Glu Thr Ala Leu 
            340                 345                 350         


Ala Asp Ser Gln Phe Leu Ala Trp Leu Ala Asp Glu Thr Lys Lys Lys 
        355                 360                 365             


Ser Met Phe Asp Ala Lys Arg Ala Val Val Ala Leu Lys Trp Lys Gly 
    370                 375                 380                 


Ile Glu Leu Arg Gly Val Ala Phe Asp Leu Leu Leu Ala Ala Tyr Leu 
385                 390                 395                 400 


Leu Asn Pro Ala Gln Asp Ala Gly Asp Ile Ala Ala Val Ala Lys Met 
                405                 410                 415     


Lys Gln Tyr Glu Ala Val Arg Ser Asp Glu Ala Val Tyr Gly Lys Gly 
            420                 425                 430         


Val Lys Arg Ser Leu Pro Asp Glu Gln Thr Leu Ala Glu His Leu Val 
        435                 440                 445             


Arg Lys Ala Ala Ala Ile Trp Ala Leu Glu Gln Pro Phe Met Asp Asp 
    450                 455                 460                 


Leu Arg Asn Asn Glu Gln Asp Gln Leu Leu Thr Lys Leu Glu Gln Pro 
465                 470                 475                 480 


Leu Ala Ala Ile Leu Ala Glu Met Glu Phe Thr Gly Val Asn Val Asp 
                485                 490                 495     


Thr Lys Arg Leu Glu Gln Met Gly Ser Glu Leu Ala Glu Gln Leu Arg 
            500                 505                 510         


Ala Ile Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 
        515                 520                 525             


Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 
    530                 535                 540                 


Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 
545                 550                 555                 560 


Leu Glu Lys Leu Ala Pro His His Glu Ile Val Glu Asn Ile Leu His 
                565                 570                 575     


Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 
            580                 585                 590         


Lys Val Val Arg Pro Asp Thr Gly Lys Val His Thr Met Phe Asn Gln 
        595                 600                 605             


Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Ala Glu Pro Asn Leu Gln 
    610                 615                 620                 


Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 
625                 630                 635                 640 


Val Pro Ser Glu Pro Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Ser 
                645                 650                 655     


Ile Glu Leu Arg Val Leu Ala His Ile Ala Asp Asp Asp Asn Leu Ile 
            660                 665                 670         


Glu Ala Phe Gln Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 
        675                 680                 685             


Ile Phe His Val Ser Glu Glu Glu Val Thr Ala Asn Met Arg Arg Gln 
    690                 695                 700                 


Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Asp Tyr Gly 
705                 710                 715                 720 


Leu Ala Gln Asn Leu Asn Ile Thr Arg Lys Glu Ala Ala Glu Phe Ile 
                725                 730                 735     


Glu Arg Tyr Phe Ala Ser Phe Pro Gly Val Lys Gln Tyr Met Glu Asn 
            740                 745                 750         


Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 
        755                 760                 765             


Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Asn Val Arg 
    770                 775                 780                 


Ser Phe Ala Glu Arg Thr Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 
785                 790                 795                 800 


Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Ala Ala Arg Leu Lys 
                805                 810                 815     


Glu Glu Gln Leu Gln Ala Arg Leu Leu Leu Gln Val His Asp Glu Leu 
            820                 825                 830         


Ile Leu Glu Ala Pro Lys Glu Glu Ile Glu Arg Leu Cys Glu Leu Val 
        835                 840                 845             


Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 
    850                 855                 860                 


Asp Tyr His Tyr Gly Pro Thr Trp Tyr Asp Ala Lys 
865                 870                 875     


<210>  277
<211>  876
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  277

Met Lys Lys Lys Leu Val Leu Ile Asp Gly Asn Ser Val Ala Tyr Arg 
1               5                   10                  15      


Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 
            20                  25                  30          


Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 
        35                  40                  45              


Glu Gln Pro Thr His Leu Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 
    50                  55                  60                  


Phe Arg His Glu Thr Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 
65                  70                  75                  80  


Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Lys 
                85                  90                  95      


Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Asp His Tyr Glu Ala Asp Asp 
            100                 105                 110         


Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 
        115                 120                 125             


Lys Ile Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Arg His 
    130                 135                 140                 


Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 
145                 150                 155                 160 


Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 
                165                 170                 175     


Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 
            180                 185                 190         


Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Lys Gln Phe 
        195                 200                 205             


Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Val Lys Gly Glu 
    210                 215                 220                 


Lys Leu Lys Glu Asn Leu Arg Gln His Arg Asp Leu Ala Leu Leu Ser 
225                 230                 235                 240 


Lys Gln Leu Ala Ser Ile Cys Arg Asp Ala Pro Val Glu Leu Ser Leu 
                245                 250                 255     


Asp Asp Ile Val Tyr Glu Gly Gln Asp Arg Glu Lys Val Ile Ala Leu 
            260                 265                 270         


Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Ala Ala Pro 
        275                 280                 285             


Ala Ala Glu Gly Glu Lys Pro Leu Glu Glu Met Glu Phe Ala Ile Val 
    290                 295                 300                 


Asp Val Ile Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 
305                 310                 315                 320 


Glu Val Met Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 
                325                 330                 335     


Leu Val Asn Glu His Gly Arg Phe Phe Met Arg Pro Glu Thr Ala Leu 
            340                 345                 350         


Ala Asp Ser Gln Phe Leu Ala Trp Leu Ala Asp Glu Thr Lys Lys Lys 
        355                 360                 365             


Ser Met Phe Asp Ala Lys Arg Ala Val Val Ala Leu Lys Trp Lys Gly 
    370                 375                 380                 


Ile Glu Leu Arg Gly Val Ala Phe Asp Leu Leu Leu Ala Ala Tyr Leu 
385                 390                 395                 400 


Leu Asn Pro Ala Gln Asp Ala Gly Asp Ile Ala Ala Val Ala Lys Met 
                405                 410                 415     


Lys Gln Tyr Glu Ala Val Arg Ser Asp Glu Ala Val Tyr Gly Lys Gly 
            420                 425                 430         


Val Lys Arg Ser Leu Pro Asp Glu Gln Thr Leu Ala Glu His Leu Val 
        435                 440                 445             


Arg Lys Ala Ala Ala Ile Trp Ala Leu Glu Gln Pro Phe Met Asp Asp 
    450                 455                 460                 


Leu Arg Asn Asn Glu Gln Asp Gln Leu Leu Thr Lys Leu Glu Gln Pro 
465                 470                 475                 480 


Leu Ala Ala Ile Leu Ala Glu Met Glu Phe Thr Gly Val Asn Val Asp 
                485                 490                 495     


Thr Lys Arg Leu Glu Gln Met Gly Ser Glu Leu Ala Glu Gln Leu Arg 
            500                 505                 510         


Ala Ile Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 
        515                 520                 525             


Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 
    530                 535                 540                 


Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 
545                 550                 555                 560 


Leu Glu Lys Leu Ala Pro His His Glu Ile Val Glu Asn Ile Leu His 
                565                 570                 575     


Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 
            580                 585                 590         


Lys Val Val Arg Pro Asp Thr Gly Lys Val His Thr Met Phe Asn Gln 
        595                 600                 605             


Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Ala Glu Pro Asn Leu Gln 
    610                 615                 620                 


Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 
625                 630                 635                 640 


Val Pro Ser Glu Pro Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Ala 
                645                 650                 655     


Ile Glu Leu Arg Val Leu Ala His Ile Ala Asp Asp Asp Asn Leu Ile 
            660                 665                 670         


Glu Ala Phe Gln Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 
        675                 680                 685             


Ile Phe His Val Ser Glu Glu Glu Val Thr Ala Asn Met Arg Arg Gln 
    690                 695                 700                 


Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Asp Tyr Gly 
705                 710                 715                 720 


Leu Ala Gln Asn Leu Asn Ile Thr Arg Lys Glu Ala Ala Glu Phe Ile 
                725                 730                 735     


Glu Arg Tyr Phe Ala Ser Phe Pro Gly Val Lys Gln Tyr Met Glu Asn 
            740                 745                 750         


Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 
        755                 760                 765             


Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Asn Val Arg 
    770                 775                 780                 


Ser Phe Ala Glu Arg Thr Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 
785                 790                 795                 800 


Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Ala Ala Arg Leu Lys 
                805                 810                 815     


Glu Glu Gln Leu Gln Ala Arg Leu Leu Leu Gln Val His Asp Glu Leu 
            820                 825                 830         


Ile Leu Glu Ala Pro Lys Glu Glu Ile Glu Arg Leu Cys Glu Leu Val 
        835                 840                 845             


Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 
    850                 855                 860                 


Asp Tyr His Tyr Gly Pro Thr Trp Tyr Asp Ala Lys 
865                 870                 875     


<210>  278
<211>  876
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  278

Met Lys Lys Lys Leu Val Leu Ile Asp Gly Asn Ser Val Ala Tyr Arg 
1               5                   10                  15      


Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 
            20                  25                  30          


Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 
        35                  40                  45              


Glu Gln Pro Thr His Leu Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 
    50                  55                  60                  


Phe Arg His Glu Thr Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 
65                  70                  75                  80  


Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Lys 
                85                  90                  95      


Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Asp His Tyr Glu Ala Asp Asp 
            100                 105                 110         


Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 
        115                 120                 125             


Lys Ile Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Arg His 
    130                 135                 140                 


Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 
145                 150                 155                 160 


Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 
                165                 170                 175     


Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 
            180                 185                 190         


Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Lys Gln Phe 
        195                 200                 205             


Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Val Lys Gly Glu 
    210                 215                 220                 


Lys Leu Lys Glu Asn Leu Arg Gln His Arg Asp Leu Ala Leu Leu Ser 
225                 230                 235                 240 


Lys Gln Leu Ala Ser Ile Cys Arg Asp Ala Pro Val Glu Leu Ser Leu 
                245                 250                 255     


Asp Asp Ile Val Tyr Glu Gly Gln Asp Arg Glu Lys Val Ile Ala Leu 
            260                 265                 270         


Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Ala Ala Pro 
        275                 280                 285             


Ala Ala Glu Gly Glu Lys Pro Leu Glu Glu Met Glu Phe Ala Ile Val 
    290                 295                 300                 


Asp Val Ile Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 
305                 310                 315                 320 


Glu Val Met Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 
                325                 330                 335     


Leu Val Asn Glu His Gly Arg Phe Phe Met Arg Pro Glu Thr Ala Leu 
            340                 345                 350         


Ala Asp Ser Gln Phe Leu Ala Trp Leu Ala Asp Glu Thr Lys Lys Lys 
        355                 360                 365             


Ser Met Phe Asp Ala Lys Arg Ala Val Val Ala Leu Lys Trp Lys Gly 
    370                 375                 380                 


Ile Glu Leu Arg Gly Val Ala Phe Asp Leu Leu Leu Ala Ala Tyr Leu 
385                 390                 395                 400 


Leu Asn Pro Ala Gln Asp Ala Gly Asp Ile Ala Ala Val Ala Lys Met 
                405                 410                 415     


Lys Gln Tyr Glu Ala Val Arg Ser Asp Glu Ala Val Tyr Gly Lys Gly 
            420                 425                 430         


Val Lys Arg Ser Leu Pro Asp Glu Gln Thr Leu Ala Glu His Leu Val 
        435                 440                 445             


Arg Lys Ala Ala Ala Ile Trp Ala Leu Glu Gln Pro Phe Met Asp Asp 
    450                 455                 460                 


Leu Arg Asn Asn Glu Gln Asp Gln Leu Leu Thr Lys Leu Glu Gln Pro 
465                 470                 475                 480 


Leu Ala Ala Ile Leu Ala Glu Met Glu Phe Thr Gly Val Asn Val Asp 
                485                 490                 495     


Thr Lys Arg Leu Glu Gln Met Gly Ser Glu Leu Ala Glu Gln Leu Arg 
            500                 505                 510         


Ala Ile Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 
        515                 520                 525             


Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 
    530                 535                 540                 


Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 
545                 550                 555                 560 


Leu Glu Lys Leu Ala Pro His His Glu Ile Val Glu Asn Ile Leu His 
                565                 570                 575     


Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 
            580                 585                 590         


Lys Val Val Arg Pro Asp Thr Gly Lys Val His Thr Met Phe Asn Gln 
        595                 600                 605             


Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Ala Glu Pro Asn Leu Gln 
    610                 615                 620                 


Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 
625                 630                 635                 640 


Val Pro Ser Glu Pro Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Ala 
                645                 650                 655     


Ala Ala Leu Arg Val Leu Ala His Ile Ala Asp Asp Asp Asn Leu Ile 
            660                 665                 670         


Glu Ala Phe Gln Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 
        675                 680                 685             


Ile Phe His Val Ser Glu Glu Glu Val Thr Ala Asn Met Arg Arg Gln 
    690                 695                 700                 


Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Asp Tyr Gly 
705                 710                 715                 720 


Leu Ala Gln Asn Leu Asn Ile Thr Arg Lys Glu Ala Ala Glu Phe Ile 
                725                 730                 735     


Glu Arg Tyr Phe Ala Ser Phe Pro Gly Val Lys Gln Tyr Met Glu Asn 
            740                 745                 750         


Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 
        755                 760                 765             


Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Asn Val Arg 
    770                 775                 780                 


Ser Phe Ala Glu Arg Thr Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 
785                 790                 795                 800 


Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Ala Ala Arg Leu Lys 
                805                 810                 815     


Glu Glu Gln Leu Gln Ala Arg Leu Leu Leu Gln Val His Asp Glu Leu 
            820                 825                 830         


Ile Leu Glu Ala Pro Lys Glu Glu Ile Glu Arg Leu Cys Glu Leu Val 
        835                 840                 845             


Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 
    850                 855                 860                 


Asp Tyr His Tyr Gly Pro Thr Trp Tyr Asp Ala Lys 
865                 870                 875     


<210>  279
<211>  876
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  279

Met Lys Lys Lys Leu Val Leu Ile Asp Gly Asn Ser Val Ala Tyr Arg 
1               5                   10                  15      


Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 
            20                  25                  30          


Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 
        35                  40                  45              


Glu Gln Pro Thr His Leu Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 
    50                  55                  60                  


Phe Arg His Glu Thr Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 
65                  70                  75                  80  


Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Lys 
                85                  90                  95      


Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Asp His Tyr Glu Ala Asp Asp 
            100                 105                 110         


Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 
        115                 120                 125             


Lys Ile Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Arg His 
    130                 135                 140                 


Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 
145                 150                 155                 160 


Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 
                165                 170                 175     


Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 
            180                 185                 190         


Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Lys Gln Phe 
        195                 200                 205             


Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Val Lys Gly Glu 
    210                 215                 220                 


Lys Leu Lys Glu Asn Leu Arg Gln His Arg Asp Leu Ala Leu Leu Ser 
225                 230                 235                 240 


Lys Gln Leu Ala Ser Ile Cys Arg Asp Ala Pro Val Glu Leu Ser Leu 
                245                 250                 255     


Asp Asp Ile Val Tyr Glu Gly Gln Asp Arg Glu Lys Val Ile Ala Leu 
            260                 265                 270         


Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Ala Ala Pro 
        275                 280                 285             


Ala Ala Glu Gly Glu Lys Pro Leu Glu Glu Met Glu Phe Ala Ile Val 
    290                 295                 300                 


Asp Val Ile Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 
305                 310                 315                 320 


Glu Val Met Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 
                325                 330                 335     


Leu Val Asn Glu His Gly Arg Phe Phe Met Arg Pro Glu Thr Ala Leu 
            340                 345                 350         


Ala Asp Ser Gln Phe Leu Ala Trp Leu Ala Asp Glu Thr Lys Lys Lys 
        355                 360                 365             


Ser Met Phe Asp Ala Lys Arg Ala Val Val Ala Leu Lys Trp Lys Gly 
    370                 375                 380                 


Ile Glu Leu Arg Gly Val Ala Phe Asp Leu Leu Leu Ala Ala Tyr Leu 
385                 390                 395                 400 


Leu Asn Pro Ala Gln Asp Ala Gly Asp Ile Ala Ala Val Ala Lys Met 
                405                 410                 415     


Lys Gln Tyr Glu Ala Val Arg Ser Asp Glu Ala Val Tyr Gly Lys Gly 
            420                 425                 430         


Val Lys Arg Ser Leu Pro Asp Glu Gln Thr Leu Ala Glu His Leu Val 
        435                 440                 445             


Arg Lys Ala Ala Ala Ile Trp Ala Leu Glu Gln Pro Phe Met Asp Asp 
    450                 455                 460                 


Leu Arg Asn Asn Glu Gln Asp Gln Leu Leu Thr Lys Leu Glu Gln Pro 
465                 470                 475                 480 


Leu Ala Ala Ile Leu Ala Glu Met Glu Phe Thr Gly Val Asn Val Asp 
                485                 490                 495     


Thr Lys Arg Leu Glu Gln Met Gly Ser Glu Leu Ala Glu Gln Leu Arg 
            500                 505                 510         


Ala Ile Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 
        515                 520                 525             


Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 
    530                 535                 540                 


Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 
545                 550                 555                 560 


Leu Glu Lys Leu Ala Pro His His Glu Ile Val Glu Asn Ile Leu His 
                565                 570                 575     


Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 
            580                 585                 590         


Lys Val Val Arg Pro Asp Thr Gly Lys Val His Thr Met Phe Asn Gln 
        595                 600                 605             


Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Ala Glu Pro Asn Leu Gln 
    610                 615                 620                 


Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 
625                 630                 635                 640 


Val Pro Ser Glu Pro Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Ser 
                645                 650                 655     


Ala Ala Leu Arg Val Leu Ala His Ile Ala Asp Asp Asp Asn Leu Ile 
            660                 665                 670         


Glu Ala Phe Gln Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 
        675                 680                 685             


Ile Phe His Val Ser Glu Glu Glu Val Thr Ala Asn Met Arg Arg Gln 
    690                 695                 700                 


Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Asp Tyr Gly 
705                 710                 715                 720 


Leu Ala Gln Asn Leu Asn Ile Thr Arg Lys Glu Ala Ala Glu Phe Ile 
                725                 730                 735     


Glu Arg Tyr Phe Ala Ser Phe Pro Gly Val Lys Gln Tyr Met Glu Asn 
            740                 745                 750         


Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 
        755                 760                 765             


Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Asn Val Arg 
    770                 775                 780                 


Ser Phe Ala Glu Arg Thr Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 
785                 790                 795                 800 


Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Ala Ala Arg Leu Lys 
                805                 810                 815     


Glu Glu Gln Leu Gln Ala Arg Leu Leu Leu Gln Val His Asp Glu Leu 
            820                 825                 830         


Ile Leu Glu Ala Pro Lys Glu Glu Ile Glu Arg Leu Cys Glu Leu Val 
        835                 840                 845             


Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 
    850                 855                 860                 


Asp Tyr His Tyr Gly Pro Thr Trp Tyr Asp Ala Lys 
865                 870                 875     


<210>  280
<211>  775
<212>  PRT
<213>  Thermococcus sp.

<400>  280

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Val Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Val Thr Ala Lys Arg His Gly Thr Val Val Lys 
    50                  55                  60                  


Val Lys Arg Ala Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Asn His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Arg Ile Arg Ala His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Thr Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Gly Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Arg Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Glu Leu Gly Ile Lys Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Ser Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Lys Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Gly Gly Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Arg Lys Met Lys Ala Thr Val Asp Pro Leu Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Val Ile Arg Glu Leu 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Leu 
    530                 535                 540                 


His Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Lys Tyr Ile Asn Pro Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Arg Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Ala Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Lys Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Lys Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Val Lys Gly Lys Lys 
    770                 775 


<210>  281
<211>  775
<212>  PRT
<213>  Thermococcus sp.

<400>  281

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Val Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Val Thr Ala Lys Arg His Gly Thr Val Val Lys 
    50                  55                  60                  


Val Lys Arg Ala Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Asn His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Arg Ile Arg Ala His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Thr Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Gly Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Arg Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Glu Leu Gly Ile Lys Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Ser Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Lys Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Gly Gly Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Arg Lys Met Lys Ala Thr Val Asp Pro Leu Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Val Ile Arg Glu Leu 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Leu 
    530                 535                 540                 


His Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Lys Tyr Ile Asn Pro Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Arg Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Ala Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Lys Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Lys Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Val Lys Gly Lys Lys 
    770                 775 


<210>  282
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  282

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Val Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Val Thr Ala Lys Arg His Gly Thr Val Val Lys 
    50                  55                  60                  


Val Lys Arg Ala Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Asn His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Arg Ile Arg Ala His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Thr Met Leu Ala Phe Ala Ile Ala Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Gly Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Arg Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Glu Leu Gly Ile Lys Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Ser Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Lys Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Gly Gly Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Arg Lys Met Lys Ala Thr Val Asp Pro Leu Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Leu Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Val Ile Arg Glu Leu 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Leu 
    530                 535                 540                 


His Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Lys Tyr Ile Asn Pro Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Arg Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Ala Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Lys Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Lys Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Val Lys Gly Lys Lys 
    770                 775 


<210>  283
<211>  1702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  283

Met Ile Leu Asp Thr Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 
            20                  25                  30          


His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Ala Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg 
    50                  55                  60                  


Val Leu Asp Ala Val Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Ile Phe Glu His Pro Gln Asp Val Pro Ala Met 
                85                  90                  95      


Arg Gly Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Phe Tyr His Glu Gly Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Val Gln Val Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Val Arg Leu Val Leu Gly Arg Asp Lys Glu His Pro Glu 
225                 230                 235                 240 


Pro Lys Ile Gln Arg Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly 
                245                 250                 255     


Arg Ile His Phe Asp Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu 
            260                 265                 270         


Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr 
        275                 280                 285             


Lys Ser Lys Leu Gly Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu 
    290                 295                 300                 


Glu Ser Met Lys Lys Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala 
305                 310                 315                 320 


Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala 
                325                 330                 335     


Lys Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 
            340                 345                 350         


Asn Leu Val Glu Trp Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu 
        355                 360                 365             


Leu Ala Pro Asn Lys Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg 
    370                 375                 380                 


Thr Thr Tyr Leu Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Ile Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Val Thr His Asn Val Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Lys 
            420                 425                 430         


Asn Tyr Asp Val Ala Pro Ile Val Gly Tyr Arg Phe Cys Lys Asp Phe 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln 
    450                 455                 460                 


Asp Ile Lys Lys Lys Met Lys Ser Thr Ile Asp Pro Ile Glu Lys Lys 
465                 470                 475                 480 


Met Leu Asp Tyr Arg Gln Arg Ala Ile Lys Leu Leu Ala Asn Ser Ile 
                485                 490                 495     


Leu Pro Asn Glu Trp Leu Pro Ile Ile Glu Asn Gly Glu Ile Lys Phe 
            500                 505                 510         


Val Lys Ile Gly Glu Phe Ile Asn Ser Tyr Met Glu Lys Gln Lys Glu 
        515                 520                 525             


Asn Val Lys Thr Val Glu Asn Thr Glu Val Leu Glu Val Asn Asn Leu 
    530                 535                 540                 


Phe Ala Phe Ser Phe Asn Lys Lys Ile Lys Glu Ser Glu Val Lys Lys 
545                 550                 555                 560 


Val Lys Ala Leu Ile Arg His Lys Tyr Lys Gly Lys Ala Tyr Glu Ile 
                565                 570                 575     


Gln Leu Ser Ser Gly Arg Lys Ile Asn Ile Thr Ala Gly His Ser Leu 
            580                 585                 590         


Phe Thr Val Arg Asn Gly Glu Ile Lys Glu Val Ser Gly Asp Gly Ile 
        595                 600                 605             


Lys Glu Gly Asp Leu Ile Val Ala Pro Lys Lys Ile Lys Leu Asn Glu 
    610                 615                 620                 


Lys Gly Val Ser Ile Asn Ile Pro Glu Leu Ile Ser Asp Leu Ser Glu 
625                 630                 635                 640 


Glu Glu Thr Ala Asp Ile Val Met Thr Ile Ser Ala Lys Gly Arg Lys 
                645                 650                 655     


Asn Phe Phe Lys Gly Met Leu Arg Thr Leu Arg Trp Met Phe Gly Glu 
            660                 665                 670         


Glu Asn Arg Arg Ile Arg Thr Phe Asn Arg Tyr Leu Phe His Leu Glu 
        675                 680                 685             


Lys Leu Gly Leu Ile Lys Leu Leu Pro Arg Gly Tyr Glu Val Thr Asp 
    690                 695                 700                 


Trp Glu Arg Leu Lys Lys Tyr Lys Gln Leu Tyr Glu Lys Leu Ala Gly 
705                 710                 715                 720 


Ser Val Lys Tyr Asn Gly Asn Lys Arg Glu Tyr Leu Val Met Phe Asn 
                725                 730                 735     


Glu Ile Lys Asp Phe Ile Ser Tyr Phe Pro Gln Lys Glu Leu Glu Glu 
            740                 745                 750         


Trp Lys Ile Gly Thr Leu Asn Gly Phe Arg Thr Asn Cys Ile Leu Lys 
        755                 760                 765             


Val Asp Glu Asp Phe Gly Lys Leu Leu Gly Tyr Tyr Val Ser Glu Gly 
    770                 775                 780                 


Tyr Ala Gly Ala Gln Lys Asn Lys Thr Gly Gly Ile Ser Tyr Ser Val 
785                 790                 795                 800 


Lys Leu Tyr Asn Glu Asp Pro Asn Val Leu Glu Ser Met Lys Asn Val 
                805                 810                 815     


Ala Glu Lys Phe Phe Gly Lys Val Arg Val Asp Arg Asn Cys Val Ser 
            820                 825                 830         


Ile Ser Lys Lys Met Ala Tyr Leu Val Met Lys Cys Leu Cys Gly Ala 
        835                 840                 845             


Leu Ala Glu Asn Lys Arg Ile Pro Ser Val Ile Leu Thr Ser Pro Glu 
    850                 855                 860                 


Pro Val Arg Trp Ser Phe Leu Glu Ala Tyr Phe Thr Gly Asp Gly Asp 
865                 870                 875                 880 


Ile His Pro Ser Lys Arg Phe Arg Leu Ser Thr Lys Ser Glu Leu Leu 
                885                 890                 895     


Ala Asn Gln Leu Val Phe Leu Leu Asn Ser Leu Gly Ile Ser Ser Val 
            900                 905                 910         


Lys Ile Gly Phe Asp Ser Gly Val Tyr Arg Val Tyr Ile Asn Glu Asp 
        915                 920                 925             


Leu Gln Phe Pro Gln Thr Ser Arg Glu Lys Asn Thr Tyr Tyr Ser Asn 
    930                 935                 940                 


Leu Ile Pro Lys Glu Ile Leu Arg Asp Val Phe Gly Lys Glu Phe Gln 
945                 950                 955                 960 


Lys Asn Met Thr Phe Lys Lys Phe Lys Glu Leu Val Asp Ser Gly Lys 
                965                 970                 975     


Leu Asn Arg Glu Lys Ala Lys Leu Leu Glu Phe Phe Ile Asn Gly Asp 
            980                 985                 990         


Ile Val Leu Asp Arg Val Lys Ser  Val Lys Glu Lys Asp  Tyr Glu Gly 
        995                 1000                 1005             


Tyr Val  Tyr Asp Leu Ser Val  Glu Asp Asn Glu Asn  Phe Leu Val 
    1010                 1015                 1020             


Gly Phe  Gly Leu Leu Tyr Ala  His Asn Ser Tyr Tyr  Gly Tyr Met 
    1025                 1030                 1035             


Gly Tyr  Pro Lys Ala Arg Trp  Tyr Ser Lys Glu Cys  Ala Glu Ser 
    1040                 1045                 1050             


Val Thr  Ala Trp Gly Arg His  Tyr Ile Glu Met Thr  Ile Arg Glu 
    1055                 1060                 1065             


Ile Glu  Glu Lys Phe Gly Phe  Lys Val Leu Tyr Ala  Asp Ser Val 
    1070                 1075                 1080             


Ser Gly  Glu Ser Glu Ile Ile  Ile Arg Gln Asn Gly  Lys Ile Arg 
    1085                 1090                 1095             


Phe Val  Lys Ile Lys Asp Leu  Phe Ser Lys Val Asp  Tyr Ser Ile 
    1100                 1105                 1110             


Gly Glu  Lys Glu Tyr Cys Ile  Leu Glu Gly Val Glu  Ala Leu Thr 
    1115                 1120                 1125             


Leu Asp  Asp Asp Gly Lys Leu  Val Trp Lys Pro Val  Pro Tyr Val 
    1130                 1135                 1140             


Met Arg  His Arg Ala Asn Lys  Arg Met Phe Arg Ile  Trp Leu Thr 
    1145                 1150                 1155             


Asn Ser  Trp Tyr Ile Asp Val  Thr Glu Asp His Ser  Leu Ile Gly 
    1160                 1165                 1170             


Tyr Leu  Asn Thr Ser Lys Thr  Lys Thr Ala Lys Lys  Ile Gly Glu 
    1175                 1180                 1185             


Arg Leu  Lys Glu Val Lys Pro  Phe Glu Leu Gly Lys  Ala Val Lys 
    1190                 1195                 1200             


Ser Leu  Ile Cys Pro Asn Ala  Pro Leu Lys Asp Glu  Asn Thr Lys 
    1205                 1210                 1215             


Thr Ser  Glu Ile Ala Val Lys  Phe Trp Glu Leu Val  Gly Leu Ile 
    1220                 1225                 1230             


Val Gly  Asp Gly Asn Trp Gly  Gly Asp Ser Arg Trp  Ala Glu Tyr 
    1235                 1240                 1245             


Tyr Leu  Gly Leu Ser Thr Gly  Lys Asp Ala Glu Glu  Ile Lys Gln 
    1250                 1255                 1260             


Lys Leu  Leu Glu Pro Leu Lys  Thr Tyr Gly Val Ile  Ser Asn Tyr 
    1265                 1270                 1275             


Tyr Pro  Lys Asn Glu Lys Gly  Asp Phe Asn Ile Leu  Ala Lys Ser 
    1280                 1285                 1290             


Leu Val  Lys Phe Met Lys Arg  His Phe Lys Asp Glu  Lys Gly Arg 
    1295                 1300                 1305             


Arg Lys  Ile Pro Glu Phe Met  Tyr Glu Leu Pro Val  Thr Tyr Ile 
    1310                 1315                 1320             


Glu Ala  Phe Leu Arg Gly Leu  Phe Ser Ala Asp Gly  Thr Val Thr 
    1325                 1330                 1335             


Ile Arg  Lys Gly Val Pro Glu  Ile Arg Leu Thr Asn  Ile Asp Ala 
    1340                 1345                 1350             


Asp Phe  Leu Arg Glu Val Arg  Lys Leu Leu Trp Ile  Val Gly Ile 
    1355                 1360                 1365             


Ser Asn  Ser Ile Phe Ala Glu  Thr Thr Pro Asn Arg  Tyr Asn Gly 
    1370                 1375                 1380             


Val Ser  Thr Gly Thr Tyr Ser  Lys His Leu Arg Ile  Lys Asn Lys 
    1385                 1390                 1395             


Trp Arg  Phe Ala Glu Arg Ile  Gly Phe Leu Ile Glu  Arg Lys Gln 
    1400                 1405                 1410             


Lys Arg  Leu Leu Glu His Leu  Lys Ser Ala Arg Val  Lys Arg Asn 
    1415                 1420                 1425             


Thr Ile  Asp Phe Gly Phe Asp  Leu Val His Val Lys  Lys Val Glu 
    1430                 1435                 1440             


Glu Ile  Pro Tyr Glu Gly Tyr  Val Tyr Asp Ile Glu  Val Glu Glu 
    1445                 1450                 1455             


Thr His  Arg Phe Phe Ala Asn  Asn Ile Leu Val His  Asn Thr Asp 
    1460                 1465                 1470             


Gly Phe  Tyr Ala Thr Ile Pro  Gly Glu Lys Pro Glu  Leu Ile Lys 
    1475                 1480                 1485             


Lys Lys  Ala Lys Glu Phe Leu  Asn Tyr Ile Asn Ser  Lys Leu Pro 
    1490                 1495                 1500             


Gly Leu  Leu Glu Leu Glu Tyr  Glu Gly Phe Tyr Leu  Arg Gly Phe 
    1505                 1510                 1515             


Phe Val  Thr Lys Lys Arg Tyr  Ala Val Ile Asp Glu  Glu Gly Arg 
    1520                 1525                 1530             


Ile Thr  Thr Arg Gly Leu Glu  Val Val Arg Arg Asp  Trp Ser Glu 
    1535                 1540                 1545             


Ile Ala  Lys Glu Thr Gln Ala  Lys Val Leu Glu Ala  Ile Leu Lys 
    1550                 1555                 1560             


Glu Gly  Ser Val Glu Lys Ala  Val Glu Val Val Arg  Asp Val Val 
    1565                 1570                 1575             


Glu Lys  Ile Ala Lys Tyr Arg  Val Pro Leu Glu Lys  Leu Val Ile 
    1580                 1585                 1590             


His Glu  Gln Ile Thr Arg Asp  Leu Lys Asp Tyr Lys  Ala Ile Gly 
    1595                 1600                 1605             


Pro His  Val Ala Ile Ala Lys  Arg Leu Ala Ala Arg  Gly Ile Lys 
    1610                 1615                 1620             


Val Lys  Pro Gly Thr Ile Ile  Ser Tyr Ile Val Leu  Lys Gly Ser 
    1625                 1630                 1635             


Gly Lys  Ile Ser Asp Arg Val  Ile Leu Leu Thr Glu  Tyr Asp Pro 
    1640                 1645                 1650             


Arg Lys  His Lys Tyr Asp Pro  Asp Tyr Tyr Ile Glu  Asn Gln Val 
    1655                 1660                 1665             


Leu Pro  Ala Val Leu Arg Ile  Leu Glu Ala Phe Gly  Tyr Arg Lys 
    1670                 1675                 1680             


Glu Asp  Leu Arg Tyr Gln Ser  Ser Lys Gln Thr Gly  Leu Asp Ala 
    1685                 1690                 1695             


Trp Leu  Lys Arg 
    1700         


<210>  284
<211>  1312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  284

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Gln Ile 
        35                  40                  45              


Asp Glu Val Arg Lys Ile Thr Ala Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Ile Asp Ala Glu Lys Val Arg Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Arg Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Ser Ala Val Ile Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Lys Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Ile Arg Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Leu Pro Tyr Leu Val Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Pro Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Leu Gly Asp Met Thr Ala Val Glu Ile Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Tyr Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Ala Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Gly 
385                 390                 395                 400 


Leu Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr 
            420                 425                 430         


Asp Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Lys Arg Leu Leu Asp Glu Arg Gln Glu Ile 
    450                 455                 460                 


Lys Arg Lys Met Lys Ala Ser Lys Asp Pro Ile Glu Lys Lys Met Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Ile Leu Pro 
                485                 490                 495     


Glu Glu Trp Val Pro Leu Ile Lys Asn Gly Lys Val Lys Ile Phe Arg 
            500                 505                 510         


Ile Gly Asp Phe Val Asp Gly Leu Met Lys Ala Asn Gln Gly Lys Val 
        515                 520                 525             


Lys Lys Thr Gly Asp Thr Glu Val Leu Glu Val Ala Gly Ile His Ala 
    530                 535                 540                 


Phe Ser Phe Asp Arg Lys Ser Lys Lys Ala Arg Val Met Ala Val Lys 
545                 550                 555                 560 


Ala Val Ile Arg His Arg Tyr Ser Gly Asn Val Tyr Arg Ile Val Leu 
                565                 570                 575     


Asn Ser Gly Arg Lys Ile Thr Ile Thr Glu Gly His Ser Leu Phe Val 
            580                 585                 590         


Tyr Arg Asn Gly Asp Leu Val Glu Ala Thr Gly Glu Asp Val Lys Ile 
        595                 600                 605             


Gly Asp Leu Leu Ala Val Pro Arg Ser Val Asn Leu Pro Glu Lys Arg 
    610                 615                 620                 


Glu Arg Leu Asn Ile Val Glu Leu Leu Leu Asn Leu Ser Pro Glu Glu 
625                 630                 635                 640 


Thr Glu Asp Ile Ile Leu Thr Ile Pro Val Lys Gly Arg Lys Asn Phe 
                645                 650                 655     


Phe Lys Gly Met Leu Arg Thr Leu Arg Trp Ile Phe Gly Glu Glu Lys 
            660                 665                 670         


Arg Val Arg Thr Ala Ser Arg Tyr Leu Arg His Leu Glu Asn Leu Gly 
        675                 680                 685             


Tyr Ile Arg Leu Arg Lys Ile Gly Tyr Asp Ile Ile Asp Lys Glu Gly 
    690                 695                 700                 


Leu Glu Lys Tyr Arg Thr Leu Tyr Glu Lys Leu Val Asp Val Val Arg 
705                 710                 715                 720 


Tyr Asn Gly Asn Lys Arg Glu Tyr Leu Val Glu Phe Asn Ala Val Arg 
                725                 730                 735     


Asp Val Ile Ser Leu Met Pro Glu Glu Glu Leu Lys Glu Trp Arg Ile 
            740                 745                 750         


Gly Thr Arg Asn Gly Phe Arg Met Gly Thr Phe Val Asp Ile Asp Glu 
        755                 760                 765             


Asp Phe Ala Lys Leu Leu Gly Tyr Tyr Val Ser Glu Gly Ser Ala Arg 
    770                 775                 780                 


Lys Trp Lys Asn Gln Thr Gly Gly Trp Ser Tyr Thr Val Arg Leu Tyr 
785                 790                 795                 800 


Asn Glu Asn Asp Glu Val Leu Asp Asp Met Glu His Leu Ala Lys Lys 
                805                 810                 815     


Phe Phe Gly Lys Val Lys Arg Gly Lys Asn Tyr Val Glu Ile Pro Lys 
            820                 825                 830         


Lys Met Ala Tyr Ile Ile Phe Glu Ser Leu Cys Gly Thr Leu Ala Glu 
        835                 840                 845             


Asn Lys Arg Val Pro Glu Val Ile Phe Thr Ser Ser Lys Gly Val Arg 
    850                 855                 860                 


Trp Ala Phe Leu Glu Gly Tyr Phe Ile Gly Asp Gly Asp Val His Pro 
865                 870                 875                 880 


Ser Lys Arg Val Arg Leu Ser Thr Lys Ser Glu Leu Leu Val Asn Gly 
                885                 890                 895     


Leu Val Leu Leu Leu Asn Ser Leu Gly Val Ser Ala Ile Lys Leu Gly 
            900                 905                 910         


Tyr Asp Ser Gly Val Tyr Arg Val Tyr Val Asn Glu Glu Leu Lys Phe 
        915                 920                 925             


Thr Glu Tyr Arg Lys Lys Lys Asn Val Tyr His Ser His Ile Val Pro 
    930                 935                 940                 


Lys Asp Ile Leu Lys Glu Thr Phe Gly Lys Val Phe Gln Lys Asn Ile 
945                 950                 955                 960 


Ser Tyr Lys Lys Phe Arg Glu Leu Val Glu Asn Gly Lys Leu Asp Arg 
                965                 970                 975     


Glu Lys Ala Lys Arg Ile Glu Trp Leu Leu Asn Gly Asp Ile Val Leu 
            980                 985                 990         


Asp Arg Val Val Glu Ile Lys Arg  Glu Tyr Tyr Asp Gly  Tyr Val Tyr 
        995                 1000                 1005             


Asp Leu  Ser Val Asp Glu Asp  Glu Asn Phe Leu Ala  Gly Phe Gly 
    1010                 1015                 1020             


Phe Leu  Tyr Ala His Asn Ser  Tyr Tyr Gly Tyr Tyr  Gly Tyr Ala 
    1025                 1030                 1035             


Lys Ala  Arg Trp Tyr Cys Lys  Glu Cys Ala Glu Ser  Val Thr Ala 
    1040                 1045                 1050             


Trp Gly  Arg Glu Tyr Ile Glu  Phe Val Arg Lys Glu  Leu Glu Glu 
    1055                 1060                 1065             


Lys Phe  Gly Phe Lys Val Leu  Tyr Ile Asp Thr Asp  Gly Leu Tyr 
    1070                 1075                 1080             


Ala Thr  Ile Pro Gly Ala Lys  Pro Glu Glu Ile Lys  Lys Lys Ala 
    1085                 1090                 1095             


Leu Glu  Phe Val Asp Tyr Ile  Asn Ala Lys Leu Pro  Gly Leu Leu 
    1100                 1105                 1110             


Glu Leu  Glu Tyr Glu Gly Phe  Tyr Val Arg Gly Phe  Phe Val Thr 
    1115                 1120                 1125             


Lys Lys  Lys Tyr Ala Leu Ile  Asp Glu Glu Gly Lys  Ile Ile Thr 
    1130                 1135                 1140             


Arg Gly  Leu Glu Ile Val Arg  Arg Asp Trp Ser Glu  Ile Ala Lys 
    1145                 1150                 1155             


Glu Thr  Gln Ala Lys Val Leu  Glu Ala Ile Leu Lys  His Gly Asn 
    1160                 1165                 1170             


Val Glu  Glu Ala Val Lys Ile  Val Lys Glu Val Thr  Glu Lys Leu 
    1175                 1180                 1185             


Ser Lys  Tyr Glu Ile Pro Pro  Glu Lys Leu Val Ile  Tyr Glu Gln 
    1190                 1195                 1200             


Ile Thr  Arg Pro Leu His Glu  Tyr Lys Ala Ile Gly  Pro His Val 
    1205                 1210                 1215             


Ala Val  Ala Lys Arg Leu Ala  Ala Arg Gly Val Lys  Val Arg Pro 
    1220                 1225                 1230             


Gly Met  Val Ile Gly Tyr Ile  Val Leu Arg Gly Asp  Gly Pro Ile 
    1235                 1240                 1245             


Ser Lys  Arg Ala Ile Leu Ala  Glu Glu Phe Asp Leu  Arg Lys His 
    1250                 1255                 1260             


Lys Tyr  Asp Ala Glu Tyr Tyr  Ile Glu Asn Gln Val  Leu Pro Ala 
    1265                 1270                 1275             


Val Leu  Arg Ile Leu Glu Ala  Phe Gly Tyr Arg Lys  Glu Asp Leu 
    1280                 1285                 1290             


Arg Trp  Gln Lys Thr Lys Gln  Thr Gly Leu Thr Ala  Trp Leu Asn 
    1295                 1300                 1305             


Ile Lys  Lys Lys 
    1310         


<210>  285
<211>  775
<212>  PRT
<213>  Pyrococcus furiosus

<400>  285

Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 
            20                  25                  30          


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 
65                  70                  75                  80  


Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 
                85                  90                  95      


Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Thr Gly Gly Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
385                 390                 395                 400 


Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 
            420                 425                 430         


Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 
625                 630                 635                 640 


Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 
        675                 680                 685             


Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Ser 
    770                 775 


<210>  286
<211>  771
<212>  PRT
<213>  Pyrococcus sp.

<400>  286

Met Ile Ile Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Lys Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Asp Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Thr Glu Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Glu Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Thr Pro 
        115                 120                 125             


Met Glu Gly Asn Glu Glu Leu Thr Phe Leu Ala Val Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Lys Val Ile Thr Trp Lys Ser Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Leu Val Lys Val Ile Arg Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu Leu Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Pro Leu Gly Arg Asp Asn Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Met Gly Asp Ser Leu Ala Val Glu Ile Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Phe Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Ser Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Phe 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ala Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Glu Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Gly 
385                 390                 395                 400 


Ile Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Asn Cys Lys Glu Tyr 
            420                 425                 430         


Asp Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly Asn Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Lys Arg Met Lys Glu Ser Lys Asp Pro Val Glu Lys Lys Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Gln Tyr Ile Asp Leu Val Arg Arg Glu 
        515                 520                 525             


Leu Glu Ser Arg Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly Leu 
    530                 535                 540                 


Tyr Ala Thr Ile Pro Gly Ala Lys His Glu Glu Ile Lys Glu Lys Ala 
545                 550                 555                 560 


Leu Lys Phe Val Glu Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Ala Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile Val Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Lys Val Leu Glu Ala Ile Leu Lys His Gly Asn Val Asp Glu Ala Val 
625                 630                 635                 640 


Lys Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Ile Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu Ser Glu 
            660                 665                 670         


Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Lys Gly Val Lys Val Lys Pro Gly Met Val Ile Gly Tyr Ile Val Leu 
    690                 695                 700                 


Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala Ile Ala Ile Glu Glu Phe 
705                 710                 715                 720 


Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Lys Tyr Gln Lys Thr Lys Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Phe 
    770     


<210>  287
<211>  903
<212>  PRT
<213>  Escherichia virus

<400>  287

Met Lys Glu Phe Tyr Leu Thr Val Glu Gln Ile Gly Asp Ser Ile Phe 
1               5                   10                  15      


Glu Arg Tyr Ile Asp Ser Asn Gly Arg Glu Arg Thr Arg Glu Val Glu 
            20                  25                  30          


Tyr Lys Pro Ser Leu Phe Ala His Cys Pro Glu Ser Gln Ala Thr Lys 
        35                  40                  45              


Tyr Phe Asp Ile Tyr Gly Lys Pro Cys Thr Arg Lys Leu Phe Ala Asn 
    50                  55                  60                  


Met Arg Asp Ala Ser Gln Trp Ile Lys Arg Met Glu Asp Ile Gly Leu 
65                  70                  75                  80  


Glu Ala Leu Gly Met Asp Asp Phe Lys Leu Ala Tyr Leu Ser Asp Thr 
                85                  90                  95      


Tyr Asn Tyr Glu Ile Lys Tyr Asp His Thr Lys Ile Arg Val Ala Asn 
            100                 105                 110         


Phe Asp Ile Glu Val Thr Ser Pro Asp Gly Phe Pro Glu Pro Ser Gln 
        115                 120                 125             


Ala Lys His Pro Ile Asp Ala Ile Thr His Tyr Asp Ser Ile Asp Asp 
    130                 135                 140                 


Arg Phe Tyr Val Phe Asp Leu Leu Asn Ser Pro Tyr Gly Asn Val Glu 
145                 150                 155                 160 


Glu Trp Ser Ile Glu Ile Ala Ala Lys Leu Gln Glu Gln Gly Gly Asp 
                165                 170                 175     


Glu Val Pro Ser Glu Ile Ile Asp Lys Ile Ile Tyr Met Pro Phe Asp 
            180                 185                 190         


Asn Glu Lys Glu Leu Leu Met Glu Tyr Leu Asn Phe Trp Gln Gln Lys 
        195                 200                 205             


Thr Pro Val Ile Leu Thr Gly Trp Asn Val Glu Ser Phe Asp Ile Pro 
    210                 215                 220                 


Tyr Val Tyr Asn Arg Ile Lys Asn Ile Phe Gly Glu Ser Thr Ala Lys 
225                 230                 235                 240 


Arg Leu Ser Pro His Arg Lys Thr Arg Val Lys Val Ile Glu Asn Met 
                245                 250                 255     


Tyr Gly Ser Arg Glu Ile Ile Thr Leu Phe Gly Ile Ser Val Leu Asp 
            260                 265                 270         


Tyr Ile Asp Leu Tyr Lys Lys Phe Ser Phe Thr Asn Gln Pro Ser Tyr 
        275                 280                 285             


Ser Leu Asp Tyr Ile Ser Glu Phe Glu Leu Asn Val Gly Lys Leu Lys 
    290                 295                 300                 


Tyr Asp Gly Pro Ile Ser Lys Leu Arg Glu Ser Asn His Gln Arg Tyr 
305                 310                 315                 320 


Ile Ser Tyr Asn Ile Ile Asp Val Tyr Arg Val Leu Gln Ile Asp Ala 
                325                 330                 335     


Lys Arg Gln Phe Ile Asn Leu Ser Leu Asp Met Gly Tyr Tyr Ala Lys 
            340                 345                 350         


Ile Gln Ile Gln Ser Val Phe Ser Pro Ile Lys Thr Trp Asp Ala Ile 
        355                 360                 365             


Ile Phe Asn Ser Leu Lys Glu Gln Asn Lys Val Ile Pro Gln Gly Arg 
    370                 375                 380                 


Ser His Pro Val Gln Pro Tyr Pro Gly Ala Phe Val Lys Glu Pro Ile 
385                 390                 395                 400 


Pro Asn Arg Tyr Lys Tyr Val Met Ser Phe Asp Leu Thr Ser Leu Tyr 
                405                 410                 415     


Pro Ser Ile Ile Arg Gln Val Asn Ile Ser Pro Glu Thr Ile Ala Gly 
            420                 425                 430         


Thr Phe Lys Val Ala Pro Leu His Asp Tyr Ile Asn Ala Val Ala Glu 
        435                 440                 445             


Arg Pro Ser Asp Val Tyr Ser Cys Ser Pro Asn Gly Met Met Tyr Tyr 
    450                 455                 460                 


Lys Asp Arg Asp Gly Val Val Pro Thr Glu Ile Thr Lys Val Phe Asn 
465                 470                 475                 480 


Gln Arg Lys Glu His Lys Gly Tyr Met Leu Ala Ala Gln Arg Asn Gly 
                485                 490                 495     


Glu Ile Ile Lys Glu Ala Leu His Asn Pro Asn Leu Ser Val Asp Glu 
            500                 505                 510         


Pro Leu Asp Val Asp Tyr Arg Phe Asp Phe Ser Asp Glu Ile Lys Glu 
        515                 520                 525             


Lys Ile Lys Lys Leu Ser Ala Lys Ser Leu Asn Glu Met Leu Phe Arg 
    530                 535                 540                 


Ala Gln Arg Thr Glu Val Ala Gly Met Thr Ala Gln Ile Asn Arg Lys 
545                 550                 555                 560 


Leu Leu Ile Asn Ser Leu Tyr Gly Ala Leu Gly Asn Val Trp Phe Arg 
                565                 570                 575     


Tyr Tyr Asp Leu Arg Asn Ala Thr Ala Ile Thr Thr Phe Gly Gln Met 
            580                 585                 590         


Ala Leu Gln Trp Ile Glu Arg Lys Val Asn Glu Tyr Leu Asn Glu Val 
        595                 600                 605             


Cys Gly Thr Glu Gly Glu Ala Phe Val Leu Tyr Gly Asp Thr Asp Ser 
    610                 615                 620                 


Ile Tyr Val Ser Ala Asp Lys Ile Ile Asp Lys Val Gly Glu Ser Lys 
625                 630                 635                 640 


Phe Arg Asp Thr Asn His Trp Val Asp Phe Leu Asp Lys Phe Ala Arg 
                645                 650                 655     


Glu Arg Met Glu Pro Ala Ile Asp Arg Gly Phe Arg Glu Met Cys Glu 
            660                 665                 670         


Tyr Met Asn Asn Lys Gln His Leu Met Phe Met Asp Arg Glu Ala Ile 
        675                 680                 685             


Ala Gly Pro Pro Leu Gly Ser Lys Gly Ile Gly Gly Phe Trp Thr Gly 
    690                 695                 700                 


Lys Lys Arg Tyr Ala Leu Asn Val Trp Asp Met Glu Gly Thr Arg Tyr 
705                 710                 715                 720 


Ala Glu Pro Lys Leu Lys Ile Met Gly Leu Glu Thr Gln Lys Ser Ser 
                725                 730                 735     


Thr Pro Lys Ala Val Gln Lys Ala Leu Lys Glu Cys Ile Arg Arg Met 
            740                 745                 750         


Leu Gln Glu Gly Glu Glu Ser Leu Gln Glu Tyr Phe Lys Glu Phe Glu 
        755                 760                 765             


Lys Glu Phe Arg Gln Leu Asn Tyr Ile Ser Ile Ala Ser Val Ser Ser 
    770                 775                 780                 


Ala Asn Asn Ile Ala Lys Tyr Asp Val Gly Gly Phe Pro Gly Pro Lys 
785                 790                 795                 800 


Cys Pro Phe His Ile Arg Gly Ile Leu Thr Tyr Asn Arg Ala Ile Lys 
                805                 810                 815     


Gly Asn Ile Asp Ala Pro Gln Val Val Glu Gly Glu Lys Val Tyr Val 
            820                 825                 830         


Leu Pro Leu Arg Glu Gly Asn Pro Phe Gly Asp Lys Cys Ile Ala Trp 
        835                 840                 845             


Pro Ser Gly Thr Glu Ile Thr Asp Leu Ile Lys Asp Asp Val Leu His 
    850                 855                 860                 


Trp Met Asp Tyr Thr Val Leu Leu Glu Lys Thr Phe Ile Lys Pro Leu 
865                 870                 875                 880 


Glu Gly Phe Thr Ser Ala Ala Lys Leu Asp Tyr Glu Lys Lys Ala Ser 
                885                 890                 895     


Leu Phe Asp Met Phe Asp Phe 
            900             


<210>  288
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  288

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Tyr Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  289
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  289

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Gly His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  290
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  290

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Arg Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  291
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  291

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Gly Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  292
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  292

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Gly Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  293
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  293

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Met Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  294
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  294

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Gly Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  295
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  295

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Gln Leu 
                485                 490                 495     


Leu Ala Gly Ser Met Tyr Gly Tyr Phe Gly Ser Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  296
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  296

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Ala Ile Ser His Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  297
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  297

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  298
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  298

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Ile Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Asn Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Cys Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  299
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  299

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Ala Leu 
                485                 490                 495     


Leu Ala Gly Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  300
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  300

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met His Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  301
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  301

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Ser Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  302
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  302

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Ser Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  303
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  303

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ile 
                405                 410                 415     


Ile Val Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  304
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  304

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Val Val 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  305
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  305

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Ser Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  306
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  306

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Val Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  307
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  307

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Val 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  308
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  308

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Tyr Val Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  309
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  309

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Val Leu 
                405                 410                 415     


Tyr Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  310
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  310

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu Arg 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asn Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Val Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Ile Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asp Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  311
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  311

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Arg Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Ile Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  312
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  312

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Phe Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  313
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  313

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Ser Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asn Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  314
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  314

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Gly Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  315
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  315

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala His Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  316
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  316

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Gly Leu 
                405                 410                 415     


Tyr Val Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  317
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  317

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Ser Leu 
                485                 490                 495     


Leu Ala Ser Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  318
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  318

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Val Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  319
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  319

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Lys Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu Arg 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asn Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Val Arg Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Val Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asn Val Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Val Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Ile Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Ser Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Ile Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asp Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  320
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  320

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Arg Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Lys 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  321
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  321

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Arg Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  322
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  322

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Arg Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  323
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  323

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys 
        755                 760                 765     


<210>  324
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  324

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Ile Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  325
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  325

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Lys Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  326
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  326

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Ile Lys Gln Gln Ala Leu Lys Ala 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  327
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  327

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Arg Ser Leu Lys Ala 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  328
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  328

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Ile Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  329
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  329

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Ala Ser Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  330
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  330

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Met Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  331
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  331

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Gly Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  332
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  332

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Asp Met Glu Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Gln Leu 
                485                 490                 495     


Leu Ala Ala Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  333
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  333

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Lys Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu Arg 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asn Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Val Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Val Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asn Val Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Val Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Ile Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Ser Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Ile Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asp Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  334
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  334

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Val Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  335
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  335

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Arg Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  336
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  336

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Trp Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  337
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  337

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Gly Val Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  338
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  338

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Gly Val Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  339
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  339

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Gly Gly 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  340
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  340

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Pro Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  341
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  341

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Gly Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Gly Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  342
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  342

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Ile Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Ala Arg Gly Met Ala Glu Tyr Ile Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asp Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  343
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  343

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Lys Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  344
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  344

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Gly Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  345
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  345

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ile 
                405                 410                 415     


Ser Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  346
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  346

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Gly Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  347
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  347

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Ile Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  348
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  348

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Ala Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Leu Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  349
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  349

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Asp Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  350
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  350

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Ala 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Lys 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  351
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  351

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu His Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  352
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  352

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Gly Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  353
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  353

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Val 
                405                 410                 415     


Ala Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  354
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  354

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  355
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  355

Met Lys Lys Thr Leu Leu Asp Ala Asp Phe Ile Thr Arg Lys Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu Arg 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asn Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Val Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Val Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Val Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Gly Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Ser Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Asp Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asp Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  356
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  356

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Ser Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  357
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  357

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Arg Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  358
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  358

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Ser Leu 
                485                 490                 495     


Leu Ala Ala Ser Met Thr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  359
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  359

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Val Leu Gln Leu 
                485                 490                 495     


Leu Ala Val Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  360
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  360

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Thr 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  361
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  361

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Ser Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  362
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  362

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Val 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  363
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  363

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Ser Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Ser 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  364
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  364

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Lys Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu Arg 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asn Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Val Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Ile Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  365
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  365

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Val 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  366
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  366

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  367
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  367

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ala Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  368
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  368

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ile 
                405                 410                 415     


Ser Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  369
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  369

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Val Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  370
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  370

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Ser Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  371
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  371

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gly Ser Leu Lys Ala 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  372
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  372

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ile 
                405                 410                 415     


Gly Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  373
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  373

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ala 
                405                 410                 415     


Ile Thr Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  374
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  374

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  375
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  375

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Thr 
                405                 410                 415     


Ala Ala Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  376
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  376

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Val Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Val Thr Ala Lys Arg His Gly Thr Val Val Lys 
    50                  55                  60                  


Val Lys Arg Ala Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Asn His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Arg Ile Arg Ala His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Ala Glu Gly Asp Glu Glu Leu Thr Met Leu Ala Phe Ala Ile Ala Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Gly Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Arg Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Glu Leu Gly Ile Lys Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Ser Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Lys Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Gly Gly Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Ser Ala Gly Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Arg Lys Met Lys Ala Thr Val Asp Pro Leu Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ser Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Leu Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr His Glu Met Val Ile Arg Glu Leu 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Leu 
    530                 535                 540                 


His Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Asp Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Lys Tyr Ile Asn Pro Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Arg Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Ala Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Lys Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Lys Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Val Lys Gly Lys Lys 
    770                 775 


<210>  377
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  377

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Val Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Val Thr Ala Lys Arg His Gly Thr Val Val Lys 
    50                  55                  60                  


Val Lys Arg Ala Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Asn His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Arg Ile Arg Ala His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Ala Glu Gly Asp Glu Glu Leu Thr Met Leu Ala Phe Ala Ile Ala Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Gly Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Arg Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Glu Leu Gly Ile Lys Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Ser Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Lys Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Gly Gly Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Phe Ala Gly Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Arg Lys Met Lys Ala Thr Val Asp Pro Leu Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ser Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Leu Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr His Glu Met Val Ile Arg Glu Leu 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Leu 
    530                 535                 540                 


His Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Asp Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Lys Tyr Ile Asn Pro Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Arg Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Ala Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Lys Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Lys Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Val Lys Gly Lys Lys 
    770                 775 


<210>  378
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  378

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Val Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Val Thr Ala Lys Arg His Gly Thr Val Val Lys 
    50                  55                  60                  


Val Lys Arg Ala Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Asn His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Arg Ile Arg Ala His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Ala Glu Gly Asp Glu Glu Leu Thr Met Leu Ala Phe Ala Ile Ala Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Gly Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Arg Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Glu Leu Gly Ile Lys Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Ser Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Lys Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Gly Gly Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Phe Ala Gly Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Arg Lys Met Lys Ala Thr Val Asp Pro Leu Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ser Ile Lys Ile Leu Ala Asn Gly Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Leu Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr His Glu Met Val Ile Arg Glu Leu 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Leu 
    530                 535                 540                 


His Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Asp Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Lys Tyr Ile Asn Pro Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Arg Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Ala Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Lys Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Lys Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Val Lys Gly Lys Lys 
    770                 775 


<210>  379
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  379

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Val Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Val Thr Ala Lys Arg His Gly Thr Val Val Lys 
    50                  55                  60                  


Val Lys Arg Ala Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Asn His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Arg Ile Arg Ala His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Thr Met Leu Ala Phe Ala Ile Ala Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Gly Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Arg Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Glu Leu Gly Ile Lys Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Ser Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Lys Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Gly Gly Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Ser Ala Gly Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Arg Lys Met Lys Ala Thr Val Asp Pro Leu Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ser Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Leu Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr His Glu Met Val Ile Arg Glu Leu 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Leu 
    530                 535                 540                 


His Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Asp Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Lys Tyr Ile Asn Pro Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Arg Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Ala Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Lys Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Lys Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Val Lys Gly Lys Lys 
    770                 775 


<210>  380
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  380

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Val Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Val Thr Ala Lys Arg His Gly Thr Val Val Lys 
    50                  55                  60                  


Val Lys Arg Ala Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Asn His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Arg Ile Arg Ala His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Thr Met Leu Ala Phe Ala Ile Ala Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Gly Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Arg Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Glu Leu Gly Ile Lys Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Ser Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Lys Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Gly Gly Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Phe Ala Gly Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Arg Lys Met Lys Ala Thr Val Asp Pro Leu Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ser Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Leu Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr His Glu Met Val Ile Arg Glu Leu 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Leu 
    530                 535                 540                 


His Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Asp Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Lys Tyr Ile Asn Pro Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Arg Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Ala Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Lys Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Lys Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Val Lys Gly Lys Lys 
    770                 775 


<210>  381
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  381

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Val Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Val Thr Ala Lys Arg His Gly Thr Val Val Lys 
    50                  55                  60                  


Val Lys Arg Ala Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Asn His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Arg Ile Arg Ala His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Thr Met Leu Ala Phe Ala Ile Ala Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Gly Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Arg Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Glu Leu Gly Ile Lys Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Ser Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Lys Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Gly Gly Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Phe Ala Gly Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Arg Lys Met Lys Ala Thr Val Asp Pro Leu Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ser Ile Lys Ile Leu Ala Asn Gly Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Leu Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr His Glu Met Val Ile Arg Glu Leu 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Leu 
    530                 535                 540                 


His Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Asp Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Lys Tyr Ile Asn Pro Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Arg Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Ala Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Lys Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Lys Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Val Lys Gly Lys Lys 
    770                 775 


<210>  382
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  382

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Val Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Val Thr Ala Lys Arg His Gly Thr Val Val Lys 
    50                  55                  60                  


Val Lys Arg Ala Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Asn His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Arg Ile Arg Ala His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Ala Glu Gly Asp Glu Glu Leu Thr Met Leu Ala Phe Ala Ile Ala Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Gly Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Arg Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Glu Leu Gly Ile Lys Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Ser Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Lys Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Gly Gly Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Ser Ala Gly Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Arg Lys Met Lys Ala Thr Val Asp Pro Leu Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ser Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Leu Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr His Glu Met Val Ile Arg Glu Leu 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Leu 
    530                 535                 540                 


His Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Asp Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Lys Tyr Ile Asn Pro Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Arg Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Ala Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Lys Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Lys Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Val Lys Gly Lys Lys 
    770                 775 


<210>  383
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  383

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Val Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Val Thr Ala Lys Arg His Gly Thr Val Val Lys 
    50                  55                  60                  


Val Lys Arg Ala Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Asn His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Arg Ile Arg Ala His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Ala Glu Gly Asp Glu Glu Leu Thr Met Leu Ala Phe Ala Ile Ala Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Gly Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Arg Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Glu Leu Gly Ile Lys Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Ser Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Lys Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Gly Gly Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Phe Ala Gly Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Arg Lys Met Lys Ala Thr Val Asp Pro Leu Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ser Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Leu Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr His Glu Met Val Ile Arg Glu Leu 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Leu 
    530                 535                 540                 


His Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Asp Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Lys Tyr Ile Asn Pro Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Arg Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Ala Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Lys Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Lys Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Val Lys Gly Lys Lys 
    770                 775 


<210>  384
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  384

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Val Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Val Thr Ala Lys Arg His Gly Thr Val Val Lys 
    50                  55                  60                  


Val Lys Arg Ala Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Asn His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Arg Ile Arg Ala His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Ala Glu Gly Asp Glu Glu Leu Thr Met Leu Ala Phe Ala Ile Ala Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Gly Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Arg Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Glu Leu Gly Ile Lys Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Ser Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Lys Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Gly Gly Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Phe Ala Gly Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Arg Lys Met Lys Ala Thr Val Asp Pro Leu Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ser Ile Lys Ile Leu Ala Asn Gly Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Leu Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr His Glu Met Val Ile Arg Glu Leu 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Leu 
    530                 535                 540                 


His Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Asp Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Lys Tyr Ile Asn Pro Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Arg Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Ala Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Lys Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Lys Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Val Lys Gly Lys Lys 
    770                 775 


<210>  385
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  385

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Val Val Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  386
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  386

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Ala Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  387
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  387

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Ala Val Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  388
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  388

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Gly 
                405                 410                 415     


Gly Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  389
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  389

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Val Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  390
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  390

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Ile Lys Gln Gln Ser Leu Lys Ala 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  391
<211>  778
<212>  PRT
<213>  Unknown

<220>
<223>  Description of Unknown: Candidatus Altiarchaeales archaeon 
       sequence

<400>  391

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Val Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Asp Met Glu Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Lys 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Asn Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Ser Gln Gly Ser Tyr Thr 
    770                 775             


<210>  392
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  392

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  393
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  393

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Leu 
                405                 410                 415     


Tyr Pro Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Arg Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


Ile Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  394
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  394

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Lys Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu Arg 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asn Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Val Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Ile Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asp Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  395
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  395

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Ser 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ala Leu Lys Ala 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asn Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  396
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  396

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Gly Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Ser Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Gln Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Asp 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  397
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  397

Met Lys Lys Thr Leu Leu Asp Ala Asp Tyr Ile Thr Arg Glu Glu Lys 
1               5                   10                  15      


Ala Val Val Arg Leu Phe Tyr Lys Thr Glu Glu Gly Arg Glu Ile Gln 
            20                  25                  30          


Glu Val Ala Asp Phe Arg Pro Tyr Met Tyr Val Leu Pro Glu Glu His 
        35                  40                  45              


Asp Leu Lys Lys Leu Gln Arg Glu Ile Lys Glu Leu Lys Asn Ile Thr 
    50                  55                  60                  


Asn Val Glu Ile Lys Arg Met Ile Glu Gly Asp Arg Glu Val Glu Val 
65                  70                  75                  80  


Leu Lys Val Met Val Asn Gln Pro Arg Asp Val Pro Asn Leu Arg Gly 
                85                  90                  95      


Leu Ile Lys Glu Leu Glu Gly Cys Lys Glu Val Arg Glu Ala His Ile 
            100                 105                 110         


Pro Phe Ala Glu Arg Tyr Leu Ile Asp Ser Gly Leu Ile Pro Met Gln 
        115                 120                 125             


Asp Cys Glu Asn Phe Asp Leu Arg Ile Ala Ala Phe Ala Met Ala Val 
    130                 135                 140                 


Tyr Asn Pro Arg Gly Glu Pro Lys Ala Glu Arg Asp Pro Ile Ile Ile 
145                 150                 155                 160 


Ile Ser Tyr Ala Asp Asn Arg Gly Leu Arg Arg Val Trp Thr Tyr Lys 
                165                 170                 175     


Thr Val Glu Asn Leu Asn Leu Asp Tyr Met Glu Val Leu Lys Asp Glu 
            180                 185                 190         


Arg Glu Ile Ile Arg Arg Phe Ile Asp Thr Ile Arg Glu Arg Glu Ile 
        195                 200                 205             


Asp Ile Ile Val Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Lys His Arg Ile Pro Val Ser Leu Gly Val Asp 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Leu Glu Arg Arg Gly Met Asn Leu Gly Ala Arg 
                245                 250                 255     


Val Thr Gly Arg Pro His Ile Asp Met Tyr Pro Val Cys Arg Gln Ile 
            260                 265                 270         


Phe Asn Leu Ser Arg Tyr Thr Leu Glu Asp Val Tyr Leu Glu Ile Thr 
        275                 280                 285             


Gly Arg Glu Lys Lys Asp Ile Arg Val Gly Glu Met Ala Gly Ile Trp 
    290                 295                 300                 


Asp Asn Pro Glu Lys Glu Lys Phe Lys Glu Leu Ile Glu Tyr Ala Met 
305                 310                 315                 320 


Ser Asp Ala Glu Ser Thr Leu Glu Ile Ala Ile Thr Leu Leu Pro Leu 
                325                 330                 335     


His Tyr Glu Ile Ser Arg Ile Thr Arg Glu Leu Ile Tyr Gln Ser Ser 
            340                 345                 350         


Arg Ala Gly Ser Gly Gln Arg Val Glu Ser Leu Leu Ile Lys Lys Ala 
        355                 360                 365             


Phe Glu Lys Ser Ile Leu Val Pro Asn Arg Pro Ser Asp Arg Val Val 
    370                 375                 380                 


Asn Glu Arg Gln Arg Lys Thr Tyr Ile Gly Ala Tyr Val Val Glu Pro 
385                 390                 395                 400 


Lys Arg Gly Ile His Asp Asn Ile Leu Leu Phe Asp Phe Arg Ser Phe 
                405                 410                 415     


Ala Gly Ser Ile Ile Ile Ser His Asn Ile Asp Pro Ser Thr Ile Asp 
            420                 425                 430         


Cys Glu Cys Cys Pro Glu Asp Ser Tyr Arg Ser Pro Thr Gly His Tyr 
        435                 440                 445             


Phe Cys Lys Lys Lys Arg Gly Leu Ile Pro Glu Thr Leu Asn Glu Leu 
    450                 455                 460                 


Val Gln Arg Arg Ile Glu Val Lys Lys Gly Leu Lys Asn Glu Lys Asn 
465                 470                 475                 480 


Pro Glu Arg Arg Arg Phe Leu Asp Val Lys Gln Gln Ser Leu Lys Leu 
                485                 490                 495     


Leu Ala Asn Ser Met Tyr Gly Tyr Phe Gly Phe Pro Arg Ala Arg Trp 
            500                 505                 510         


Tyr Cys Leu Glu Cys Ala Glu Ser Ile Thr Ala Leu Gly Arg Lys Tyr 
        515                 520                 525             


His Leu His Thr Ile Asp Ile Val Pro Lys Phe Gly Phe Asp Val Ile 
    530                 535                 540                 


Tyr Gly Asp Thr Asp Ser Val Tyr Leu Ile Lys Pro Asn Ile Thr Glu 
545                 550                 555                 560 


Arg Glu Arg Val Met Lys Asp Ala Glu His Phe Leu Asp Lys Ile Asn 
                565                 570                 575     


Ser Glu Leu Pro Glu Ala Met Glu Leu Glu Phe Glu Gly Phe Tyr Pro 
            580                 585                 590         


Arg Gly Ile Phe Ile Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Arg 
        595                 600                 605             


Gly Lys Leu Ile Val Lys Gly Leu Glu Thr Lys Arg Arg Asp Trp Ala 
    610                 615                 620                 


Asn Ile Ala Lys Asp Thr Gln Glu Lys Val Leu Asp Ala Leu Leu Lys 
625                 630                 635                 640 


Asp Lys Asn Pro Glu Lys Ala Ala Ser Ile Val Lys Asp Val Ile Arg 
                645                 650                 655     


Asn Ile Lys Thr Gly Lys Ile Pro Leu Lys Asp Leu Ala Ile Asn Thr 
            660                 665                 670         


Gln Ile Thr Arg Gly Met Ala Glu Tyr Lys Thr Glu Gly Pro His Ile 
        675                 680                 685             


Val Ala Ala Lys Lys Ala Met Lys Arg Gly Leu Glu Phe Lys Gln Gly 
    690                 695                 700                 


Asn Ile Val Thr Tyr Val Val Thr Lys Lys Gly Lys Ser Ile Ser Asp 
705                 710                 715                 720 


Lys Ala Arg Val Ile Asp Phe Val Glu Glu Gly Asp Tyr Asp Pro Asp 
                725                 730                 735     


Tyr Tyr Ile Asn Asn Gln Val Leu Pro Ser Val Leu Arg Ile Leu Glu 
            740                 745                 750         


Ala Leu Gly Tyr Ser Glu Asp Glu Leu Lys Gly Leu Gly Lys Gln Met 
        755                 760                 765             


Lys Leu Gly Gly Phe 
    770             


<210>  398
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6x his tag

<400>  398

His His His His His His 
1               5       


<210>  399
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Description of Unknown: Candidatus Altiarchaeales archaeon 
       sequence

<400>  399

Gln Gly Ser Tyr Thr 
1               5   


