                         SEQUENCE LISTING

<110>  Duke University
       Zennadi, Rahima
 
<120>  COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF 
       HEMOGLOBINOPATHIES

<130>  155554.00652

<150>  63/211,295
<151>  2021-06-16

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human  forward primer U32a

<400>  1
ggtcagtgat gagcaacatt caccatc                                           27


<210>  2
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human  reverse primer U32a

<400>  2
tcccgaccac cacagcc                                                      17


<210>  3
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human forward primer  U33

<400>  3
ggccggtgat gagaacttct cc                                                22


<210>  4
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human  reverse primer U33

<400>  4
tcccgaccac cacagcc                                                      17


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human  forward primer U34

<400>  5
cgtccatgat gttccgcaac tacc                                              24


<210>  6
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human  reverse primer  U34

<400>  6
tcccgaccac cacagcc                                                      17


<210>  7
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human forward primer  U35a

<400>  7
cttatctcac gatggtctgc ggatg                                             25


<210>  8
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human  reverse primer U35a

<400>  8
tcccgaccac cacagcc                                                      17


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human forward primer NOX1

<400>  9
atcctgcttc ctgtgtgtcg                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human reverse primer NOX1

<400>  10
gtcgtgtttc gggactggat                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human forward primer NOX2

<400>  11
tgtcaagtgc ccaaaggtgt                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human reverse primer NOX2

<400>  12
cccaacgatg cggatatgga                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human forward primer NOX4

<400>  13
cagtctttga ccctcggtcc                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human reverse primer NOX4

<400>  14
tgatcctcgg aggtaagcca                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human forward primer GRK2

<400>  15
tccccatacc cacaaggtca                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human reverse primer GRK2

<400>  16
cttccactgg caaaaccgtg                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human forward primer ERK1

<400>  17
gtcatcggca tccgagacat                                                   20


<210>  18
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human reverse primer ERK1

<400>  18
gactggccca cctcatcc                                                     18


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human forward primer ERK2

<400>  19
agttcttgac ccctggtcct                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human reverse primer ERK2

<400>  20
cctgggacat ccccagaaac                                                   20


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human forward primer 36B4 (Rplp0)

<400>  21
ggagacggat tacaccttcc c                                                 21


<210>  22
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Human reverse primer 36B4 (Rplp0)

<400>  22
cagccacaaa ggcagatgg                                                    19


<210>  23
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse forward primer U32a

<400>  23
gagtccatga tcagcaacac tcacc                                             25


<210>  24
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse reverse primer U32a

<400>  24
tcccgaccac cacagcc                                                      17


<210>  25
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse forward primer U33

<400>  25
agcttgtgat gagacatctc ccact                                             25


<210>  26
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse reverse primer U33

<400>  26
tcccgaccac cacagcc                                                      17


<210>  27
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse forward primer U34

<400>  27
cgtctgtgat gttctgctat tacctacatt gtt                                    33


<210>  28
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse reverse primer U34

<400>  28
tcccgaccac cacagcc                                                      17


<210>  29
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse forward primer U35a

<400>  29
ggcacatgat gttcttattc tcacgatggt                                        30


<210>  30
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse reverse primer U35a

<400>  30
tcccgaccac cacagcc                                                      17


<210>  31
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse forward primer NOX1

<400>  31
gaaattcttg ggactgcctt gg                                                22


<210>  32
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse forward primer NOX2

<400>  32
tcaactacta taaggtttat gatgatgg                                          28


<210>  33
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse reverse primer NOX2

<400>  33
cagatatcta aattatgctc ttccaaa                                           27


<210>  34
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse forward primer NOX4

<400>  34
cctgctcatt tggctgtccc ta                                                22


<210>  35
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse reverse primer NOX4

<400>  35
cggctacatg cacacctgag aa                                                22


<210>  36
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse forward primer GRK2

<400>  36
ctgccagagc ccagcatc                                                     18


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse reverse primer GRK2

<400>  37
tggcatgagg cctcttcttg                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse forward primer ERK1

<400>  38
acactggctt tctgacggag                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse reverse primer ERK1

<400>  39
tgatgcgctt gtttgggttg                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse forward primer ERK2

<400>  40
agccacacgt tggtacagag                                                   20


<210>  41
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse reverse primer ERK2

<400>  41
acttacacca tctctccctt gc                                                22


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse forward primer 36B4 (Rplp0)

<400>  42
atccctgacg caccgccgtg a                                                 21


<210>  43
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse reverse primer 36B4 (Rplp0)

<400>  43
tgcatctgct tggagcccac gtt                                               23


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-sense oligo  U32a


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  2'-O-methoxyribonucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  phosphorothioate backbone

<220>
<221>  misc_feature
<222>  (16)..(20)
<223>  2'-O-methoxyribonucleotide

<400>  44
gcggugcatg ggttgaucuc                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-sense oligo U33


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  2' -O-methoxyribonucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  phosphorothioate backbone

<220>
<221>  misc_feature
<222>  (16)..(20)
<223>  2' -O-methoxyribonucleotide

<400>  45
ugguagtgca tgtagaguca                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-sense oligo U35a


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  2' -O-methoxyribonucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  phosphorothioate backbone

<220>
<221>  misc_feature
<222>  (16)..(20)
<223>  2' -O-methoxyribonucleotide

<400>  46
uuagcctttg gcattaucgg                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-sense oligo  U34


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  2' -O-methoxyribonucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  phosphorothioate backbone

<220>
<221>  misc_feature
<222>  (16)..(20)
<223>  2' -O-methoxyribonucleotide

<400>  47
cagugggguu uucaugaggc                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-sense oligo GFP


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  2' -O-methoxyribonucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  phosphorothioate backbone

<220>
<221>  misc_feature
<222>  (16)..(20)
<223>  2' -O-methoxyribonucleotide

<400>  48
ucaccttcac cctctccacu                                                   20


<210>  49
<211>  82
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(82)
<223>  SNORD32A

<400>  49
aggtcagtga tgagcaacat tcaccatctt tcgtttgagt ctcacggcca tgagatcaac       60

cccatgcacc gctctgagac ct                                                82


<210>  50
<211>  83
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(83)
<223>  SNORD33

<400>  50
ggccggtgat gagaacttct cccactcaca ttcgagtttc ccgaccatga gatgactcca       60

catgcactac catctgaggc cac                                               83


<210>  51
<211>  66
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(66)
<223>  SNORD34

<400>  51
cgtccatgat gttccgcaac tacctacatt gtttgatcct catgaaagca gcactggctg       60

agacgc                                                                  66


<210>  52
<211>  81
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(81)
<223>  SNORD32a

<400>  52
gagtccatga tgagcaacac tcaccatctt tcgtttgagt ctcacgactg tgagatcaac       60

ccatgcaccg ctctgagact c                                                 81


<210>  53
<211>  82
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(82)
<223>  SNORD33

<400>  53
agcttgtgat gagacatctc ccactcatgt tcgagttgct cgactatgag atgactctac       60

atgcactacc atctgaggct gt                                                82


<210>  54
<211>  66
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(65)
<223>  SNORD34

<400>  54
cgtctgtgat gttctgctat tacctacatt gtttgagcct catgaaaacc ccactggctg       60

agacgc                                                                  66


<210>  55
<211>  89
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(89)
<223>  SNORD35a

<400>  55
ggcacatgat gttcttattc tcacgatggt cttcggatgc cacagttagg gcagtgccga       60

taatgccaaa ggctaagctg atgccagga                                         89


<210>  56
<211>  85
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(85)
<223>  SNORD35a

<400>  56
ggcagatgat gtccttatct cacgatggtc tgcggatgtc cctgtgggaa tggcgacaat       60

gccaatggct tagctgatgc cagga                                             85


<210>  57
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mouse reverse primer NOX1

<400>  57
gctggagaga acagaagcga ga                                                22


