                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Rape, Michael
       Schaletzky, Julia Sabine
       Wehri, Eddie Eric
       Manford, Andrew Garrett
 
<120>  E3 LIGASE INHIBITORS AND METHODS OF USE THEREOF

<130>  BERK-447WO

<150>  US 63/321,034
<151>  2022-03-17

<150>  US 63/211,868
<151>  2021-06-17

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  627
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Gly Leu Ala Gly Tyr Val Tyr Lys Ala Ala Ser Glu Gly Lys 
1               5                   10                  15      


Val Leu Thr Leu Ala Ala Leu Leu Leu Asn Arg Ser Glu Ser Asp Ile 
            20                  25                  30          


Arg Tyr Leu Leu Gly Tyr Val Ser Gln Gln Gly Gly Gln Arg Ser Thr 
        35                  40                  45              


Pro Leu Ile Ile Ala Ala Arg Asn Gly His Ala Lys Val Val Arg Leu 
    50                  55                  60                  


Leu Leu Glu His Tyr Arg Val Gln Thr Gln Gln Thr Gly Thr Val Arg 
65                  70                  75                  80  


Phe Asp Gly Tyr Val Ile Asp Gly Ala Thr Ala Leu Trp Cys Ala Ala 
                85                  90                  95      


Gly Ala Gly His Phe Glu Val Val Lys Leu Leu Val Ser His Gly Ala 
            100                 105                 110         


Asn Val Asn His Thr Thr Val Thr Asn Ser Thr Pro Leu Arg Ala Ala 
        115                 120                 125             


Cys Phe Asp Gly Arg Leu Asp Ile Val Lys Tyr Leu Val Glu Asn Asn 
    130                 135                 140                 


Ala Asn Ile Ser Ile Ala Asn Lys Tyr Asp Asn Thr Cys Leu Met Ile 
145                 150                 155                 160 


Ala Ala Tyr Lys Gly His Thr Asp Val Val Arg Tyr Leu Leu Glu Gln 
                165                 170                 175     


Arg Ala Asp Pro Asn Ala Lys Ala His Cys Gly Ala Thr Ala Leu His 
            180                 185                 190         


Phe Ala Ala Glu Ala Gly His Ile Asp Ile Val Lys Glu Leu Ile Lys 
        195                 200                 205             


Trp Arg Ala Ala Ile Val Val Asn Gly His Gly Met Thr Pro Leu Lys 
    210                 215                 220                 


Val Ala Ala Glu Ser Cys Lys Ala Asp Val Val Glu Leu Leu Leu Ser 
225                 230                 235                 240 


His Ala Asp Cys Asp Arg Arg Ser Arg Ile Glu Ala Leu Glu Leu Leu 
                245                 250                 255     


Gly Ala Ser Phe Ala Asn Asp Arg Glu Asn Tyr Asp Ile Ile Lys Thr 
            260                 265                 270         


Tyr His Tyr Leu Tyr Leu Ala Met Leu Glu Arg Phe Gln Asp Gly Asp 
        275                 280                 285             


Asn Ile Leu Glu Lys Glu Val Leu Pro Pro Ile His Ala Tyr Gly Asn 
    290                 295                 300                 


Arg Thr Glu Cys Arg Asn Pro Gln Glu Leu Glu Ser Ile Arg Gln Asp 
305                 310                 315                 320 


Arg Asp Ala Leu His Met Glu Gly Leu Ile Val Arg Glu Arg Ile Leu 
                325                 330                 335     


Gly Ala Asp Asn Ile Asp Val Ser His Pro Ile Ile Tyr Arg Gly Ala 
            340                 345                 350         


Val Tyr Ala Asp Asn Met Glu Phe Glu Gln Cys Ile Lys Leu Trp Leu 
        355                 360                 365             


His Ala Leu His Leu Arg Gln Lys Gly Asn Arg Asn Thr His Lys Asp 
    370                 375                 380                 


Leu Leu Arg Phe Ala Gln Val Phe Ser Gln Met Ile His Leu Asn Glu 
385                 390                 395                 400 


Thr Val Lys Ala Pro Asp Ile Glu Cys Val Leu Arg Cys Ser Val Leu 
                405                 410                 415     


Glu Ile Glu Gln Ser Met Asn Arg Val Lys Asn Ile Ser Asp Ala Asp 
            420                 425                 430         


Val His Asn Ala Met Asp Asn Tyr Glu Cys Asn Leu Tyr Thr Phe Leu 
        435                 440                 445             


Tyr Leu Val Cys Ile Ser Thr Lys Thr Gln Cys Ser Glu Glu Asp Gln 
    450                 455                 460                 


Cys Lys Ile Asn Lys Gln Ile Tyr Asn Leu Ile His Leu Asp Pro Arg 
465                 470                 475                 480 


Thr Arg Glu Gly Phe Thr Leu Leu His Leu Ala Val Asn Ser Asn Thr 
                485                 490                 495     


Pro Val Asp Asp Phe His Thr Asn Asp Val Cys Ser Phe Pro Asn Ala 
            500                 505                 510         


Leu Val Thr Lys Leu Leu Leu Asp Cys Gly Ala Glu Val Asn Ala Val 
        515                 520                 525             


Asp Asn Glu Gly Asn Ser Ala Leu His Ile Ile Val Gln Tyr Asn Arg 
    530                 535                 540                 


Pro Ile Ser Asp Phe Leu Thr Leu His Ser Ile Ile Ile Ser Leu Val 
545                 550                 555                 560 


Glu Ala Gly Ala His Thr Asp Met Thr Asn Lys Gln Asn Lys Thr Pro 
                565                 570                 575     


Leu Asp Lys Ser Thr Thr Gly Val Ser Glu Ile Leu Leu Lys Thr Gln 
            580                 585                 590         


Met Lys Met Ser Leu Lys Cys Leu Ala Ala Arg Ala Val Arg Ala Asn 
        595                 600                 605             


Asp Ile Asn Tyr Gln Asp Gln Ile Pro Arg Thr Leu Glu Glu Phe Val 
    610                 615                 620                 


Gly Phe His 
625         


<210>  2
<211>  627
<212>  PRT
<213>  Mus musculus

<400>  2

Met Glu Gly Leu Ala Gly Tyr Val Tyr Lys Ala Ala Ser Glu Gly Lys 
1               5                   10                  15      


Val Leu Thr Leu Ala Ala Leu Leu Leu Asn Arg Ser Glu Ser Asp Ile 
            20                  25                  30          


Arg Tyr Leu Leu Gly Tyr Val Ser Gln Gln Gly Gly Gln Arg Ser Thr 
        35                  40                  45              


Pro Leu Ile Ile Ala Ala Arg Asn Gly His Ala Lys Val Val Arg Leu 
    50                  55                  60                  


Leu Leu Glu His Tyr Arg Val Gln Thr Gln Gln Thr Gly Thr Val Arg 
65                  70                  75                  80  


Phe Asp Gly Tyr Val Ile Asp Gly Ala Thr Ala Leu Trp Cys Ala Ala 
                85                  90                  95      


Gly Ala Gly His Phe Glu Val Val Lys Leu Leu Val Ser His Gly Ala 
            100                 105                 110         


Asn Val Asn His Thr Thr Val Thr Asn Ser Thr Pro Leu Arg Ala Ala 
        115                 120                 125             


Cys Phe Asp Gly Arg Leu Asp Ile Val Lys Tyr Leu Val Glu Asn Asn 
    130                 135                 140                 


Ala Asn Ile Ser Ile Ala Asn Lys Tyr Asp Asn Thr Cys Leu Met Ile 
145                 150                 155                 160 


Ala Ala Tyr Lys Gly His Thr Asp Val Val Arg Tyr Leu Leu Glu Gln 
                165                 170                 175     


Arg Ala Asp Pro Asn Ala Lys Ala His Cys Gly Ala Thr Ala Leu His 
            180                 185                 190         


Phe Ala Ala Glu Ala Gly His Ile Asp Ile Val Lys Glu Leu Ile Lys 
        195                 200                 205             


Trp Arg Ala Ala Ile Val Val Asn Gly His Gly Met Thr Pro Leu Lys 
    210                 215                 220                 


Val Ala Ala Glu Ser Cys Lys Ala Asp Val Val Glu Leu Leu Leu Ser 
225                 230                 235                 240 


His Ala Asp Cys Asp Arg Arg Ser Arg Ile Glu Ala Leu Glu Leu Leu 
                245                 250                 255     


Gly Ala Ser Phe Ala Asn Asp Arg Glu Asn Tyr Asp Ile Met Lys Thr 
            260                 265                 270         


Tyr His Tyr Leu Tyr Leu Ala Met Leu Glu Arg Phe Gln Asp Gly Asp 
        275                 280                 285             


Asn Ile Leu Glu Lys Glu Val Leu Pro Pro Ile His Ala Tyr Gly Asn 
    290                 295                 300                 


Arg Thr Glu Cys Arg Asn Pro Gln Glu Leu Glu Ala Ile Arg Gln Asp 
305                 310                 315                 320 


Arg Asp Ala Leu His Met Glu Gly Leu Ile Val Arg Glu Arg Ile Leu 
                325                 330                 335     


Gly Ala Asp Asn Ile Asp Val Ser His Pro Ile Ile Tyr Arg Gly Ala 
            340                 345                 350         


Val Tyr Ala Asp Asn Met Glu Phe Glu Gln Cys Ile Lys Leu Trp Leu 
        355                 360                 365             


His Ala Leu His Leu Arg Gln Lys Gly Asn Arg Asn Thr His Lys Asp 
    370                 375                 380                 


Leu Leu Arg Phe Ala Gln Val Phe Ser Gln Met Ile His Leu Asn Glu 
385                 390                 395                 400 


Ala Val Lys Ala Pro Asp Ile Glu Cys Val Leu Arg Cys Ser Val Leu 
                405                 410                 415     


Glu Ile Glu Gln Ser Met Asn Arg Val Lys Asn Ile Ser Asp Ala Asp 
            420                 425                 430         


Val His Ser Ala Met Asp Asn Tyr Glu Cys Asn Leu Tyr Thr Phe Leu 
        435                 440                 445             


Tyr Leu Val Cys Ile Ser Thr Lys Thr Gln Cys Ser Glu Glu Asp Gln 
    450                 455                 460                 


Cys Arg Ile Asn Lys Gln Ile Tyr Asn Leu Ile His Leu Asp Pro Arg 
465                 470                 475                 480 


Thr Arg Glu Gly Phe Ser Leu Leu His Leu Ala Val Asn Ser Asn Thr 
                485                 490                 495     


Pro Val Asp Asp Phe His Thr Asn Asp Val Cys Ser Phe Pro Asn Ala 
            500                 505                 510         


Leu Val Thr Lys Leu Leu Leu Asp Cys Gly Ala Glu Val Asn Ala Val 
        515                 520                 525             


Asp Asn Glu Gly Asn Ser Ala Leu His Ile Ile Val Gln Tyr Asn Arg 
    530                 535                 540                 


Pro Ile Ser Asp Phe Leu Thr Leu His Ser Ile Ile Ile Ser Leu Val 
545                 550                 555                 560 


Glu Ala Gly Ala His Thr Asp Met Thr Asn Lys Gln Asn Lys Thr Pro 
                565                 570                 575     


Leu Asp Lys Ser Thr Thr Gly Val Ser Glu Ile Leu Leu Lys Thr Gln 
            580                 585                 590         


Met Lys Met Ser Leu Lys Cys Leu Ala Ala Arg Ala Val Arg Ala Asn 
        595                 600                 605             


Asp Ile Asn Tyr Gln Asp Gln Ile Pro Arg Thr Leu Glu Glu Phe Val 
    610                 615                 620                 


Gly Phe His 
625         


<210>  3
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAMRA-labeled folliculin-interacting protein 1 (FNIP1) peptide

<400>  3

Arg Asn Lys Ser Ser Leu Leu Phe Lys Glu Ser Glu Glu Thr Arg Thr 
1               5                   10                  15      


Pro Asn Cys Asn Cys Lys Tyr Cys Ser His Pro Val Leu Gly 
            20                  25                  30  


