                               SEQUENCE LISTING

<110> MASSACHUSETTS INSTITUTE OF TECHNOLOGY
 
<120> SYSTEMS, METHODS, AND COMPOSITIONS COMPRISING MINIATURE CRISPR 
      NUCLEASES FOR GENE EDITING AND PROGRAMMABLE GENE ACTIVATION AND 
      INHIBITION

<130> 727972: 083474-017PC

<140> PCT/US2022/033749
<141> 2022-06-16

<150> 63/211,610
<151> 2021-06-17

<160> 318   

<170> PatentIn version 3.5

<210> 1
<211> 586
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile 
1               5                   10                  15      


Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe 
            20                  25                  30          


Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser 
        35                  40                  45              


Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp 
    50                  55                  60                  


Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys 
65                  70                  75                  80  


Thr Phe Lys Phe Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys 
                85                  90                  95      


Asp Ile Tyr Thr Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr 
            100                 105                 110         


Ser Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn 
        115                 120                 125             


Asp Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn 
    130                 135                 140                 


Ala Pro Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala 
145                 150                 155                 160 


Ile Ser Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg 
                165                 170                 175     


Arg Ile Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile 
            180                 185                 190         


Asp Asp Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys 
        195                 200                 205             


Glu Gly His Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu 
    210                 215                 220                 


Lys Trp Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp 
225                 230                 235                 240 


Ile Glu Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu 
                245                 250                 255     


Asn Arg Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly 
            260                 265                 270         


Tyr Glu Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His 
        275                 280                 285             


Phe Ala Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys 
    290                 295                 300                 


Lys Ser Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg 
305                 310                 315                 320 


Asn Leu Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe 
                325                 330                 335     


Leu Gln Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys 
            340                 345                 350         


Asn Phe Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val 
        355                 360                 365             


Gly Cys Ile Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe 
    370                 375                 380                 


Phe Phe His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys 
385                 390                 395                 400 


Ile Arg Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys 
                405                 410                 415     


Thr Lys Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His 
            420                 425                 430         


Lys Val Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln 
        435                 440                 445             


Ile Val Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu 
    450                 455                 460                 


Asp Leu Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser 
465                 470                 475                 480 


Lys Lys Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg 
                485                 490                 495     


Met Leu Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro 
            500                 505                 510         


Val Met Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys 
        515                 520                 525             


Gly Tyr Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu 
    530                 535                 540                 


Lys Cys Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile 
545                 550                 555                 560 


Ala Lys Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu 
                565                 570                 575     


His Ala Tyr Val Cys Ser Glu Pro Asp Lys 
            580                 585     


<210> 2
<211> 534
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Glu Glu Glu Asn Phe Asp Asn Ala Glu Val Thr Thr Gly Ile Lys 
1               5                   10                  15      


Phe Lys Leu Lys Leu Asn Ser Glu Thr Arg Glu Lys Leu Asn Asn Tyr 
            20                  25                  30          


Phe Asn Glu Tyr Gly Lys Ala Ile Asn Phe Ala Val Arg Ile Ile Gln 
        35                  40                  45              


Lys Gln Leu Ala Asp Asp Arg Phe Ala Gly Lys Ala Lys Leu Asp Glu 
    50                  55                  60                  


Asn Lys Lys Gln Leu Leu Asp Glu Asp Gly Lys Lys Ile Trp Asp Phe 
65                  70                  75                  80  


Pro Ser Glu Ser Cys Ser Cys Gly Lys Gln Val Val Arg Tyr Val Asn 
                85                  90                  95      


Gly Lys Pro Phe Cys Gln Glu Cys Tyr Arg Asn Lys Phe Ser Glu Asn 
            100                 105                 110         


Gly Ile Arg Lys Arg Met Tyr Ser Ala Lys Gly Arg Lys Ala Glu Tyr 
        115                 120                 125             


Asp Ile Asn Ile Lys Asn Ser Thr Asn Arg Ile Ser Lys Thr His Phe 
    130                 135                 140                 


Asn Tyr Ala Ile Arg Glu Ala Phe Ile Leu Asp Lys Ser Ile Lys Lys 
145                 150                 155                 160 


Gln Arg Lys Glu Arg Phe Arg Arg Leu Asn Asp Met Met Arg Lys Leu 
                165                 170                 175     


Gln Glu Phe Ile Asp Ile Arg Glu Gly Lys Arg Leu Val Cys Pro Lys 
            180                 185                 190         


Ile Glu Arg Gln Lys Val Glu Arg Tyr Ile His Pro Ala Trp Ile Asn 
        195                 200                 205             


Lys Glu Lys Lys Ile Glu Glu Phe Arg Gly Tyr Ser Leu Ser Val Val 
    210                 215                 220                 


Asn Ser Lys Ile Lys Ala Leu Asp Arg Asn Ile Lys Arg Glu Glu Lys 
225                 230                 235                 240 


Ser Leu Lys Glu Lys Gly Gln Ile Asn Phe Lys Ala Arg Arg Leu Met 
                245                 250                 255     


Leu Asp Lys Ser Val Lys Phe Thr Asp Thr Asn Lys Val Ser Phe Thr 
            260                 265                 270         


Ile Ser Lys Ser Leu Pro Lys Glu Tyr Glu Leu Asp Leu Pro Lys Lys 
        275                 280                 285             


Glu Lys Arg Leu Asn Trp Leu Lys Glu Lys Ile Glu Ile Ile Lys Asn 
    290                 295                 300                 


Gln Lys Pro Lys Tyr Ala Tyr Leu Leu Arg Arg Gly Asp Asp Phe Tyr 
305                 310                 315                 320 


Leu Gln Tyr Thr Leu Gln Thr Lys Pro Glu Ile Lys Thr Thr His Ser 
                325                 330                 335     


Gly Ala Val Gly Ile Asp Arg Gly Ile Ser His Ile Ala Val Tyr Thr 
            340                 345                 350         


Phe Val Ser Asn Asp Gly Lys Asn Glu Arg Pro Leu Phe Leu Ser Ser 
        355                 360                 365             


Ser Glu Ile Leu Arg Leu Lys Asn Leu Gln Lys Glu Arg Asp Lys Phe 
    370                 375                 380                 


Leu Arg Arg Lys His Asn Lys Ile Arg Lys Lys Ser Asn Met Arg Asn 
385                 390                 395                 400 


Ile Glu Asp Lys Ile Gln Leu Ile Leu His Asn Tyr Ser Lys Gln Ile 
                405                 410                 415     


Val Asp Phe Ala Lys Glu Lys Asn Ala Phe Ile Val Phe Glu Lys Leu 
            420                 425                 430         


Glu Lys Pro Lys Lys Ser Arg Ser Lys Met Ser Lys Lys Glu Gln Tyr 
        435                 440                 445             


Lys Leu Ser Leu Phe Thr Phe Lys Lys Leu Ser Asp Leu Val Asp Tyr 
    450                 455                 460                 


Lys Ala Lys Arg Glu Gly Ile Lys Val Ile Tyr Ile Glu Pro Ala Tyr 
465                 470                 475                 480 


Thr Ser Lys Glu Cys Ser His Cys Gly Glu Lys Val Asn Thr Gln Arg 
                485                 490                 495     


Pro Phe Asn Gly Asn Tyr Ser Leu Phe Lys Cys Asn Lys Cys Gly Ile 
            500                 505                 510         


Ile Leu Asn Ser Asp Tyr Asn Ala Ser Ile Asn Ile Ala Lys Lys Gly 
        515                 520                 525             


Leu Asn Ile Phe Asn Ile 
    530                 


<210> 3
<211> 449
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Met Ala Lys Gly Glu Lys Asn Asn Asp Val Leu Tyr Arg Ala Val Lys 
1               5                   10                  15      


Phe Glu Ile Arg Pro Thr Leu Asn Gln Glu Thr Ile Leu Gln Arg Ile 
            20                  25                  30          


Ser Ser Asn Leu Arg Leu Ile Trp Asn Glu Ala Trp Lys Glu Arg Gln 
        35                  40                  45              


Asp Arg Tyr Glu Ile Phe Phe Lys Pro Ile Tyr Glu Arg Ile Tyr Asn 
    50                  55                  60                  


Ala Lys Lys Lys Ala Leu Glu Lys Gly Phe Thr Asp Leu Trp Glu Lys 
65                  70                  75                  80  


Glu Val Ala Lys Phe Ser Gln Gln Val Leu Val Lys Arg Gly Phe Pro 
                85                  90                  95      


Leu Gln Leu Val Leu Glu Gln Lys Ser Leu Phe Ala Glu Leu Lys Lys 
            100                 105                 110         


Ala Phe Glu Glu His Gly Ile Thr Leu Tyr Asp Gln Ile Asn Ala Leu 
        115                 120                 125             


Thr Ala Lys Arg Ser Leu Asn Thr Glu Phe Gly Leu Ile Pro Arg Asn 
    130                 135                 140                 


Trp Gln Glu Glu Thr Leu Asp Ala Leu Asp Gly Ser Phe Lys Ser Phe 
145                 150                 155                 160 


Phe Ala Leu Arg Lys Arg Gly Asp Lys Asp Ala Lys Pro Pro Ser Glu 
                165                 170                 175     


Arg Thr Asn Glu Asp Ser Phe Tyr Lys Ile Pro Gly Arg Ser Gly Phe 
            180                 185                 190         


Lys Val Thr Asp Asp Gly Lys Val Ile Val Ser Phe Gly Lys Leu Ser 
        195                 200                 205             


Glu Thr Leu Val Gly Arg Ile Pro Glu Tyr Gln Gln Glu Lys Leu Ser 
    210                 215                 220                 


His Ala Lys Asn Leu Lys Lys Phe Glu Ile Val Arg Asp Glu Arg Asp 
225                 230                 235                 240 


Met Ala Lys Ser Gly Cys Phe Trp Ile Ser Ile Ala Tyr Glu Ile Pro 
                245                 250                 255     


Lys Pro Pro Glu Leu Pro Phe Asn Pro Ser Lys Ala Val Phe Leu Ala 
            260                 265                 270         


Ile Gly Ala Ser Trp Ile Gly Ile Ile Ser Pro Arg Gly Glu Phe Cys 
        275                 280                 285             


Trp Arg Met Pro Arg Pro Asp Phe His Trp Lys Pro Lys Ile Asn Ala 
    290                 295                 300                 


Val Asp Glu Arg Leu Lys Arg Val Ser Lys Gly Ser Ile Lys Trp Lys 
305                 310                 315                 320 


Arg Leu Ile Phe Ala Arg Ser Lys Met Phe Ala Ile Met Ala Arg Gln 
                325                 330                 335     


Gln Lys Gln His Gly Gln Tyr Glu Val Ile Lys Arg Leu Leu Glu Leu 
            340                 345                 350         


Gly Val Cys Phe Val Val Thr Asp Leu Lys Val Arg Ser Lys Glu Gly 
        355                 360                 365             


Ser Leu Ala Asp Ser Ser Lys Ala Glu Arg Gly Gly Ser Pro Phe Gly 
    370                 375                 380                 


Ala Asn Trp Ser Ala Gln Asn Thr Gly Asn Ile Ala Asn Leu Val Ala 
385                 390                 395                 400 


Lys Leu Thr Asp His Val Ser Ala Leu Gly Gly Met Val Ile Lys Arg 
                405                 410                 415     


Lys Ser Pro Glu Leu Leu Val Glu Glu Lys Arg Leu Pro Gln Glu Lys 
            420                 425                 430         


Arg Lys Ile Leu Leu Ala Gln Lys Leu Lys Asp Glu Phe Leu Ser Leu 
        435                 440                 445             


Asn 
    


<210> 4
<211> 482
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Lys Asn Thr Lys Glu Glu Lys Trp Met Gln Thr Tyr Cys Phe Asp 
1               5                   10                  15      


Leu Thr Asp Glu Glu Phe Gly Ala Glu Asn Ile Arg Leu Ala Thr His 
            20                  25                  30          


Ile Ser Asp Ser Leu Val Pro Leu Phe Asn Glu Val Leu Leu Gln Val 
        35                  40                  45              


Leu Lys Gly Asp Glu Thr Ile Lys Glu Leu Lys Gln Glu Val Lys Leu 
    50                  55                  60                  


Arg Gly Arg Ala Leu Lys Gln Lys Ala Lys Glu Ala Gln Met Glu Asp 
65                  70                  75                  80  


Leu Trp Asp Arg Glu Asn Asn Glu Ile Asp Asp Glu Glu Trp Leu Glu 
                85                  90                  95      


Arg Gly Tyr Asp Gln Glu Val Ile Lys Glu His Arg Asp Tyr Val Asp 
            100                 105                 110         


Glu Ile Ala Lys Leu Tyr Ser Glu Asn Lys Val Thr Ala Phe Asp His 
        115                 120                 125             


Asn Tyr His Tyr Ala Gln Glu Asn Leu Glu Ala Ile Gly Cys Thr Ala 
    130                 135                 140                 


Pro Tyr Val Asn Ile Ser Ala Gly Leu Arg Arg Gly Ala Ile Lys Asn 
145                 150                 155                 160 


Cys His Gly Ala Val Asp Ser Trp Arg Lys His Leu Ala Thr Gly Asp 
                165                 170                 175     


Tyr Lys Ser Lys Pro Pro Gly Gln Gln Glu Val Gly Lys Phe Tyr Met 
            180                 185                 190         


Leu Arg Cys Glu Pro Gly Cys Ala Val Thr Lys Asp Arg Lys Asn Val 
        195                 200                 205             


Arg Ile Ser Leu Gly Asp Arg Lys Ser Ser Pro Val Phe Glu Leu Pro 
    210                 215                 220                 


Gly Leu Asp Asn Ser Lys Asn Lys Pro Leu His Met Leu Leu Arg Ser 
225                 230                 235                 240 


Asp Ala Lys Val Lys Ser Phe Thr Leu Ser Arg Arg Ser Ala Arg Asn 
                245                 250                 255     


Pro Asp Lys Lys Glu Ser Asp Leu Gln Lys Pro Gly Val Trp Arg Ile 
            260                 265                 270         


Ser Ile Asn Phe Glu Leu Pro Leu Pro Glu Lys Lys Pro Ala Thr Glu 
        275                 280                 285             


Tyr Asn Thr Val Ala Leu Val Ile Gly Ser Asn Tyr Leu Gly Val Ala 
    290                 295                 300                 


Leu His Asp Ser Glu Arg Asn Phe Pro Leu Asn Leu Pro Leu Pro His 
305                 310                 315                 320 


Lys His Trp Phe Pro Ile Ile Gly Asp Ile Glu Gly Arg Ala Asn Val 
                325                 330                 335     


Pro Trp Arg Lys Lys Gly Ser Lys Lys Trp Arg Arg Lys Met Phe Gly 
            340                 345                 350         


Val Gln Lys Lys His Ser Gly Gly Arg Gln Ala Cys Tyr Arg Tyr Met 
        355                 360                 365             


Ala Arg Gln Gln Lys Gln Gly Glu Tyr Glu Thr Ile Ala Asp His Leu 
    370                 375                 380                 


Ile Gly Cys Gly Val His Phe Val Val Ser Lys Pro Ser Ile Asn His 
385                 390                 395                 400 


Pro Lys Gly Leu Ala Asp Ala Ser Ala Pro Asp Arg Gly Gly Asp Thr 
                405                 410                 415     


Gly Pro Asn Arg Ile Ile Ser Ser Thr Gly Val Asn Ser Leu Val Leu 
            420                 425                 430         


Lys Leu Lys Gln Lys Val Lys Glu Phe Gly Gly Ser Val Thr Glu Met 
        435                 440                 445             


Glu Ala Pro Pro Leu Pro Glu Arg Phe Arg Phe Trp Asp Ser Gly Pro 
    450                 455                 460                 


Lys Lys Val Ile Val Ala Gln Leu Leu Arg Asn Gln Tyr Leu Ala Gln 
465                 470                 475                 480 


Lys Lys 
        


<210> 5
<211> 591
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Val Lys Gln Thr Thr Phe Phe Cys Lys Glu Cys Asn Lys Asn Ile 
1               5                   10                  15      


Asn Ile Pro Arg Asn Ile Ile Lys Lys Leu Glu Ser Asn His Ile Ser 
            20                  25                  30          


Gln Asp Gln Ala Ile Lys Lys Ala Lys Glu Arg His Asn Lys Lys Lys 
        35                  40                  45              


His Ser Leu Ile Leu Gly Ile Lys Phe Lys Leu Tyr Val Lys Asn Lys 
    50                  55                  60                  


Glu Asp Lys Glu Lys Leu Asn Ser Tyr Phe Glu Glu Tyr Ala Lys Ala 
65                  70                  75                  80  


Val Thr Phe Ala Ala Gln Ile Ile Asp Lys Ile Lys Ser Gly Tyr Leu 
                85                  90                  95      


Pro Gln Trp Lys Lys Asp Lys Lys Leu Lys Arg Ile Ile Phe Pro Lys 
            100                 105                 110         


Gly Lys Cys Asp Phe Cys Gly Thr Lys Thr Glu Ile Gly Trp Ile Ser 
        115                 120                 125             


Lys Arg Gly Lys Lys Ile Cys Lys Asn Cys Tyr Ser Lys Glu Tyr Gly 
    130                 135                 140                 


Glu Asn Gly Ile Arg Lys Lys Leu Tyr Ala Thr Arg Gly Arg Lys Val 
145                 150                 155                 160 


Asn Pro Ser Tyr Asn Ile Phe Asn Ala Thr Lys Lys Leu Ala Ala Thr 
                165                 170                 175     


His Tyr Asn Tyr Ala Ile Arg Glu Ala Phe Gln Leu Leu Glu Ala Asn 
            180                 185                 190         


Arg Lys Gln Arg Gln Glu Arg Ile Arg Arg Leu Leu Arg Asp Lys Lys 
        195                 200                 205             


Arg Leu Arg Glu Phe Glu Asp Leu Ile Glu Lys Pro Asp Arg Arg Ile 
    210                 215                 220                 


Glu Leu Pro Met Lys Thr Arg Gln Arg Glu Lys Arg Tyr Ile His Ile 
225                 230                 235                 240 


Ser Gln Lys Asp Lys Ile Asn Glu Leu Arg Gly Tyr Thr Leu His Lys 
                245                 250                 255     


Ile Lys Glu Lys Ile Arg Ile Leu Arg Arg Asn Thr Glu Arg Glu Glu 
            260                 265                 270         


Arg Ala Leu Arg Lys Lys Thr Pro Ile Ile Phe Lys Gly Asn Arg Ile 
        275                 280                 285             


Met Leu Phe Pro Gln Gly Ile Lys Phe Asp Lys Glu Asn Asn Lys Val 
    290                 295                 300                 


Lys Ile Thr Ile Ala Lys Asn Leu Pro Lys Glu Phe Ile Phe Ser Gly 
305                 310                 315                 320 


Thr Asn Val Ala Asn Lys His Gly Arg Arg Phe Phe Lys Glu Lys Leu 
                325                 330                 335     


Asn Leu Ile Ser Gln Gln Lys Pro Lys Tyr Ala Tyr Leu Ile Arg Lys 
            340                 345                 350         


Gln Thr Lys Asn Ser Lys Lys Ile Thr Asp Tyr Asp Tyr Tyr Leu Gln 
        355                 360                 365             


Tyr Thr Ile Glu Thr Val Tyr Lys Ile Arg Lys Asn Tyr Asp Gly Ile 
    370                 375                 380                 


Ile Gly Ile Asp Arg Gly Ile Asn Asn Leu Ala Cys Leu Val Leu Leu 
385                 390                 395                 400 


Glu Lys Asn Gln Glu Lys Pro Cys Gly Val Lys Phe Tyr Lys Gly Lys 
                405                 410                 415     


Glu Ile Asn Ala Leu Lys Ile Lys Arg Arg Lys Gln Leu Tyr Phe Leu 
            420                 425                 430         


Arg Arg Lys His Asn Arg Lys Gln Lys Gln Lys Arg Ile Arg Arg Ile 
        435                 440                 445             


Glu Pro Lys Ile Asn Gln Ile Leu His Ile Ile Ser Lys Glu Ile Val 
    450                 455                 460                 


Glu Leu Ala Lys Glu Lys Asn Phe Ala Ile Gly Leu Glu Gln Leu Glu 
465                 470                 475                 480 


Lys Pro Lys Lys Ser Arg Phe Arg Gln Arg Arg Lys Glu Arg Tyr Phe 
                485                 490                 495     


Leu Ser Leu Phe Asn Phe Lys Thr Leu Ser Thr Phe Ile Glu Tyr Lys 
            500                 505                 510         


Ala Lys Lys Glu Gly Ile Arg Val Ile Tyr Ile Pro Pro Glu Arg Thr 
        515                 520                 525             


Ser Gln Ile Cys Ser His Cys Ala Ile Lys Gly Asp Val His Thr Asn 
    530                 535                 540                 


Thr Ile Arg Pro Tyr Arg Lys Pro Asn Ala Lys Lys Ser Ser Ser Ser 
545                 550                 555                 560 


Leu Phe Lys Cys Lys Lys Cys Gly Val Glu Leu Asn Ala Asp Tyr Asn 
                565                 570                 575     


Ala Ala Phe Asn Ile Ala Gln Lys Ser Leu Lys Ile Leu Ser Thr 
            580                 585                 590     


<210> 6
<211> 373
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Lys Ile Lys Glu Gln Ser Glu Val Arg Glu Leu Leu Lys Ala Tyr 
1               5                   10                  15      


Lys Tyr Arg Ile Tyr Pro Asn Lys Glu Gln Arg Leu Tyr Leu Ala Lys 
            20                  25                  30          


Thr Phe Gly Cys Thr Arg Phe Ile Tyr Asn Lys Met Leu Ser Asp Arg 
        35                  40                  45              


Ile Lys Val Tyr Glu Glu Asn Lys Asp Leu Asp Ile Lys Lys Val Lys 
    50                  55                  60                  


Tyr Pro Thr Pro Ala Gln Tyr Lys Lys Glu Phe Thr Trp Leu Lys Glu 
65                  70                  75                  80  


Val Asp Ser Leu Ala Leu Ala Asn Ala Gln Met Asn Leu Asp Lys Ala 
                85                  90                  95      


Tyr Lys Asn Phe Phe Arg Asp Lys Ser Met Gly Phe Pro Lys Phe Lys 
            100                 105                 110         


Ser Lys Lys Val Asn Tyr Tyr Ser Tyr Thr Thr Asn Asn Gln Lys Gly 
        115                 120                 125             


Thr Val Tyr Ile Glu Asp Gly Tyr Ile Lys Leu Pro Lys Leu Lys Thr 
    130                 135                 140                 


Met Ile Lys Ile Lys Gln His Arg Lys Phe Asn Gly Leu Ile Lys Ser 
145                 150                 155                 160 


Cys Thr Ile Ser Lys Thr Pro Ser Asn Lys Tyr Tyr Ile Ser Ile Leu 
                165                 170                 175     


Val Tyr Thr Glu Asn Lys Gln Leu Pro Lys Val Asp Lys Lys Val Gly 
            180                 185                 190         


Ile Asp Val Gly Leu Lys Glu Phe Ala Ile Thr Ser Asn Gly Glu Phe 
        195                 200                 205             


Phe Ser Asn Pro Lys Trp Leu Arg Lys Ser Glu Lys Arg Leu Arg Lys 
    210                 215                 220                 


Leu Gln Lys Asp Leu Ser Arg Lys Gln Lys Gly Ser Asn Asn Arg Cys 
225                 230                 235                 240 


Lys Ala Arg Leu Lys Val Ala Lys Leu His Glu Lys Ile Thr Asn Gln 
                245                 250                 255     


Arg Lys Asn Phe Leu His Lys Leu Ser Ile Lys Leu Ile Arg Glu Asn 
            260                 265                 270         


Gln Ser Ile Val Ile Glu Asp Leu Lys Val Lys Asn Met Leu Gln Asn 
        275                 280                 285             


His Lys Leu Ala Lys Ala Ile Ser Glu Val Ser Trp Tyr Glu Phe Arg 
    290                 295                 300                 


Thr Met Leu Glu Tyr Lys Ala Asp Trp Tyr Gly Arg Glu Leu Ile Ile 
305                 310                 315                 320 


Ala Pro Ser Asn Tyr Ala Ser Ser Gln Ile Cys Ser Asn Cys Gly Tyr 
                325                 330                 335     


Lys Asn Lys Glu Val Lys Asn Leu Glu Leu Arg Glu Trp Val Cys Pro 
            340                 345                 350         


Lys Cys Gly Ile His His His Arg Asp Ile Asn Ala Ser Lys Asn Leu 
        355                 360                 365             


Leu Lys Leu Ala Ile 
    370             


<210> 7
<211> 402
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Leu Val Phe Glu Ala Lys Leu Arg Gly Thr Lys Glu Gln Tyr Glu 
1               5                   10                  15      


Arg Leu Asp Glu Ala Ile Arg Thr Ala Arg Phe Val Arg Asn Ser Cys 
            20                  25                  30          


Leu Arg Tyr Trp Met Asp Asn Lys Gly Glu Lys Val Gly Arg Tyr Glu 
        35                  40                  45              


Leu Ser Ala Tyr Cys Ala Val Leu Ala Lys Glu Phe Pro Trp Ala Lys 
    50                  55                  60                  


Lys Leu Asn Ser Met Ala Arg Gln Ala Ser Ala Glu Arg Ala Trp Thr 
65                  70                  75                  80  


Ala Ile Ala Arg Phe Tyr Asp Asn Cys Lys Lys Lys Val Ser Gly Lys 
                85                  90                  95      


Lys Gly Phe Pro Lys Phe Lys Lys Tyr Lys Thr Arg Asp Ser Val Glu 
            100                 105                 110         


Tyr Lys Thr Ser Gly Trp Lys Leu Ser Glu Asp Arg Arg Thr Ile Thr 
        115                 120                 125             


Phe Thr Asp Gly Phe Lys Ala Gly Ser Phe Lys Thr Trp Gly Thr Arg 
    130                 135                 140                 


Asp Leu His Phe Tyr Gln Leu Lys Gln Ile Lys Arg Val Arg Val Val 
145                 150                 155                 160 


Arg Arg Ala Asp Gly Tyr Tyr Val Gln Phe Cys Ile Asp Gln Asp Arg 
                165                 170                 175     


Val Glu Lys Arg Glu Pro Thr Gly Thr Ala Ile Gly Leu Asp Val Gly 
            180                 185                 190         


Leu Asn His Phe Tyr Thr Asp Ser Asp Gly Gln Thr Val Glu Asn Pro 
        195                 200                 205             


Arg His Leu Arg Lys Ser Glu Lys Ala Leu Lys Arg Leu Gln Arg Arg 
    210                 215                 220                 


Leu Ala Lys Thr Gln Lys Gly Ser Lys Asn Arg Gln Lys Ala Arg Asn 
225                 230                 235                 240 


Arg Leu Gly Arg Lys His Leu Lys Val Ser Arg Gln Arg Lys Asp Phe 
                245                 250                 255     


Ala Val Lys Thr Ala Leu Cys Val Val Gln Ser Asn Asp Leu Val Ala 
            260                 265                 270         


Tyr Glu Asp Leu Lys Val Arg Asn Met Val Lys Asn His Asn Leu Ala 
        275                 280                 285             


Lys Ser Ile Ser Asp Ala Ala Trp Ser Thr Phe Arg Gln Trp Met Glu 
    290                 295                 300                 


Tyr Phe Gly Lys Val Phe Gly Val Ala Thr Val Ala Val Pro Pro Gln 
305                 310                 315                 320 


Tyr Thr Ser Gln Asn Cys Ser Asn Cys Gly Glu Lys Ile Gln Lys Ser 
                325                 330                 335     


Leu Ser Thr Arg Thr His Arg Cys Pro His Cys Gly Phe Val Ala Asp 
            340                 345                 350         


Arg Asp His Asn Ala Ala Ile Asn Ile Leu Glu Leu Gly Leu Ser Thr 
        355                 360                 365             


Val Gly His Thr Glu Thr His Ala Ser Gly Asp Ile Asp Leu Cys Leu 
    370                 375                 380                 


Gly Gly Glu Thr Pro Gln Ser Lys Ser Ser Arg Arg Lys Arg Lys Pro 
385                 390                 395                 400 


His Gln 
        


<210> 8
<211> 387
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Asp Gln Ile Ile Lys Gly Val Lys Leu Arg Leu Tyr Pro Asn Arg 
1               5                   10                  15      


Gly Gln Lys Asp Lys Leu Trp Gln Met Phe Gly Asn Asp Arg Phe Val 
            20                  25                  30          


Trp Asn Gln Met Leu Ser Met Ala Lys Thr Arg Tyr Gln Asn Asn Pro 
        35                  40                  45              


Arg Ala Ser Phe Ile Asn Gly Tyr Gly Met Asp Thr Leu Leu Lys Val 
    50                  55                  60                  


Leu Lys Asn Glu Tyr Pro Phe Leu Lys Glu Ser Asp Ser Thr Ser Leu 
65                  70                  75                  80  


Gln Val Val Asn His Lys Leu Asn Gln Ser Phe Gln Met Leu Phe Lys 
                85                  90                  95      


His Arg Gly Gly Tyr Pro Arg Phe Lys Ser Arg Lys Ala Thr Lys Gln 
            100                 105                 110         


Ala Tyr Thr Gly Lys Ser Lys Val Ser Val Val Ala Lys Arg Cys Leu 
        115                 120                 125             


Lys Leu Pro Lys Ile Gly Tyr Ile Lys Thr Ser Lys Thr Asn Gln Leu 
    130                 135                 140                 


Val Asp Thr Lys Ile Lys Arg Tyr Thr Val Ser Tyr Asp Ala Thr Gly 
145                 150                 155                 160 


Arg Tyr Tyr Leu Ser Leu Gln Val Glu Val Pro Ala Pro Glu Leu Leu 
                165                 170                 175     


Pro Lys Thr Gly Lys Val Val Gly Leu Asp Val Gly Leu Ala Asp Leu 
            180                 185                 190         


Ala Ile Ser Ser Asp Gly Val Lys Tyr Gly Thr Phe Asn Ala Lys Trp 
        195                 200                 205             


Leu Asp Lys Gln Val Asn Lys Trp Gln Ser Ala Tyr Ala Lys Arg Lys 
    210                 215                 220                 


Tyr Arg Ala Thr Ile Ala Val Arg Gln Trp Asn His Asn His Lys Thr 
225                 230                 235                 240 


Val Lys Glu Glu Leu Asn Asp Tyr Gln Asn Trp Gln Arg Ala Arg Arg 
                245                 250                 255     


Tyr Lys Ala Arg Tyr Gln Ala Lys Val Ala Asn Lys Arg Gln Asp Asn 
            260                 265                 270         


Leu Gln Lys Leu Thr Thr Glu Leu Val Lys Gln Tyr Asp Val Ile Val 
        275                 280                 285             


Ile Glu Asp Leu Lys Thr Lys Asn Leu Gln Lys Asn His His Leu Ala 
    290                 295                 300                 


Lys Ser Ile Ala Asn Ala Ser Trp Tyr Gln Leu Arg Thr Met Leu Glu 
305                 310                 315                 320 


Tyr Lys Cys Ala Trp Tyr Gly Arg Gln Leu Ile Ile Val Lys Pro Asn 
                325                 330                 335     


Tyr Thr Ser Gln Ile Cys Ser Ser Cys Gly Tyr His Asn Gly Pro Lys 
            340                 345                 350         


Pro Leu Lys Ile Arg Glu Trp Thr Cys Ser Lys Cys Gly Val His His 
        355                 360                 365             


Asp Arg Asp Ile Asn Ala Ala Ile Asn Ile Leu His Lys Gly Leu Lys 
    370                 375                 380                 


Ala Asn Gly 
385         


<210> 9
<211> 360
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Thr Ser Asn Lys Cys Ala Glu Glu Gly Gln Lys Lys Val Ser Val 
1               5                   10                  15      


Thr Pro Ile Thr Phe Asn Phe Trp Leu Thr Lys Val Lys Asp Arg Ile 
            20                  25                  30          


Phe Glu Leu Glu Asp Gln Thr Thr Val Leu Leu Lys Asp Val Ser Val 
        35                  40                  45              


Asp Leu Ser Arg Gln Val Leu Lys Met Leu Ala Gly Ala Trp Gln Ser 
    50                  55                  60                  


Tyr Phe Glu Leu Arg Lys Arg Gly Asp Thr Glu Ala Arg Pro Pro Ser 
65                  70                  75                  80  


Pro Lys Lys Glu Gly Trp Phe Gln Thr Met Ala Trp Ser Asn Phe Thr 
                85                  90                  95      


Val Arg Gln Gly Ser Ile Phe Val Pro Gly Tyr Gln Lys Asn Arg Ile 
            100                 105                 110         


Glu Ile Lys Leu Gly Asp Tyr Leu Lys Arg Met Val Glu Asp Lys Glu 
        115                 120                 125             


Val Ala Tyr Val Thr Leu Tyr Arg Asp Arg Phe Ser Gly Glu Phe Asn 
    130                 135                 140                 


Leu Ser Val Val Val Lys Asn Pro Ala Pro Lys His Ile Glu His Pro 
145                 150                 155                 160 


Lys Val Ile Arg Ala Ile Asp Leu Gly Ala Gly Asp Ile Ala Val Ser 
                165                 170                 175     


Asp Ser Ser Gly Ala Glu Tyr Leu Ile Pro Ala Arg Arg Pro Asp Lys 
            180                 185                 190         


His Trp Met Pro Leu Ile Ala Gln Val Glu His Arg Ala Glu Arg Cys 
        195                 200                 205             


Ile Lys Gly Ser Arg Ala Tyr Lys Arg Arg Met Lys Ala Arg Arg Val 
    210                 215                 220                 


Met His Glu Lys Ser Gly Asn Gln Lys Asp Ser Tyr Gln Arg Lys Leu 
225                 230                 235                 240 


Ala Arg Ala Leu Phe Ser Gly Glu Val Glu Ala Ile Val Ile Gly Lys 
                245                 250                 255     


Gly Lys Thr Arg Leu Gly Leu Ala Gln Ser Glu Ser Gly Thr Pro Asp 
            260                 265                 270         


Gln His Tyr Gly Ala Gln Asn Thr Gly Tyr Leu Phe Arg Gln Leu Leu 
        275                 280                 285             


Tyr Ile Lys Glu Lys Ala Lys Glu Arg Gly Ile Pro Val Val Glu Phe 
    290                 295                 300                 


Pro Asp Pro Gln Arg Lys Gly Glu Leu Glu Asp Ser Gln Lys Lys Phe 
305                 310                 315                 320 


Phe Ala Ser Arg Glu Leu Leu Ser Leu Gly Cys Lys Lys Phe Lys Ile 
                325                 330                 335     


Glu Val Pro Asn Ser Phe Val Gln Gly Glu Phe Ile Phe Asn Gln Gly 
            340                 345                 350         


Lys Gly Gly Lys Pro Lys Val Ala 
        355                 360 


<210> 10
<211> 603
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Ala Ile Thr Val His Thr Ala Gly Val His Tyr Arg Trp Thr Asp 
1               5                   10                  15      


Asn Pro Pro Glu Gln Leu Met Arg Gln Leu Arg Leu Ala His Asp Leu 
            20                  25                  30          


Arg Glu Asp Leu Val Thr Leu Gln Leu Asp Tyr Glu Thr Ala Lys Ala 
        35                  40                  45              


Gly Ile Trp Ser Ser Tyr Pro Ala Val Ala Ala Ala Glu Thr Glu Leu 
    50                  55                  60                  


Ala Asp Ala Glu Ser Ala Ala Glu Gln Ala Ala Ala Ala Val Ser Glu 
65                  70                  75                  80  


Glu Arg Thr Lys Leu Arg Thr Lys Arg Ile Thr Gly Pro Leu Ala Gln 
                85                  90                  95      


Lys Leu Thr Ala Ala Arg Lys Arg Val Arg Glu Ala Arg Ser Thr Arg 
            100                 105                 110         


Arg Ala Ala Ile Ser Glu Val His Glu Glu Ala Lys Gly Arg Leu Val 
        115                 120                 125             


Asp Ala Ser Asp Ala Leu Lys Ala Gln Gln Lys Ala Leu Tyr Lys Thr 
    130                 135                 140                 


Tyr Cys Gln Asp Gly Asp Leu Phe Trp Ala Thr Phe Asn Asp Val Leu 
145                 150                 155                 160 


Asp His His Lys Ala Ala Val Lys Arg Ile Gly Gln Met Arg Ala Ala 
                165                 170                 175     


Gly Gln Pro Ala Gln Leu Arg His His Arg Phe Asp Gly Thr Gly Ser 
            180                 185                 190         


Ile Ala Val Gln Leu Gln Arg Gln Ala Gly Gln Pro Gln Arg Thr Pro 
        195                 200                 205             


Glu Leu Ile Ala Asp Val Asp Gly Lys Tyr Gly Arg Val Leu Ser Val 
    210                 215                 220                 


Pro Trp Val Gln Pro Asp Arg Trp Glu Arg Ile Pro Arg Arg Glu Arg 
225                 230                 235                 240 


Arg Met Ile Gly Arg Val Thr Val Arg Met Arg Ala Gly Gln Leu Ser 
                245                 250                 255     


Gly Glu Pro Gln Trp Leu Asp Ile Pro Val Gln Gln His Arg Met Leu 
            260                 265                 270         


Pro Leu Asp Ala Asp Ile Thr Gly Ala Arg Leu Thr Val Thr Arg Thr 
        275                 280                 285             


Ala Gly Thr Leu Arg Ala Gln Ile Ser Val Thr Ala Lys Ile Pro Asp 
    290                 295                 300                 


Pro Glu Pro Val Thr Asp Gly Pro Asp Val Ala Val His Leu Gly Trp 
305                 310                 315                 320 


Arg Asn Thr Asp Thr Gly Val Arg Val Ala Arg Trp Arg Ser Thr Glu 
                325                 330                 335     


Pro Ile Glu Val Pro Phe Asp Phe Arg Asp Thr Leu Thr Val Asp Pro 
            340                 345                 350         


Gly Gly Arg Ser Gly Glu Ile Phe Val Pro Glu Ala Val Pro Arg Arg 
        355                 360                 365             


Val Glu Arg Ala His Leu Ile Ala Ser His Arg Ala Asp Arg Met Asn 
    370                 375                 380                 


Glu Leu Arg Ala Arg Leu Val Asp Tyr Leu Ala Glu Thr Gly Pro Arg 
385                 390                 395                 400 


Pro His Pro Ser Arg Glu Gly Glu Glu Leu Gly Ala Gly Asn Val Arg 
                405                 410                 415     


Met Trp Lys Ser Pro Asn Arg Phe Ala Trp Leu Ala Arg Val Trp Ala 
            420                 425                 430         


Asp Asp Glu Ser Val Ser Thr Asp Ile Arg Glu Ala Leu Ala Gln Trp 
        435                 440                 445             


Arg His Gln Asp Trp Ile Ser Trp His His Gln Glu Gly Gly Arg Arg 
    450                 455                 460                 


Arg Ser Ala Ala Gln Arg Leu Asp Val Tyr Arg Gln Val Ala Ala Val 
465                 470                 475                 480 


Leu Val Ser Gln Ala Gly Arg Leu Val Leu Asp Asp Thr Ser Tyr Ala 
                485                 490                 495     


Asp Ile Ala Gln Arg Ser Ala Thr Thr Lys Thr Glu Glu Leu Pro Asn 
            500                 505                 510         


Glu Thr Ala Ala Arg Ile Asn Arg Arg Arg Ala His Ala Ala Pro Gly 
        515                 520                 525             


Glu Leu Arg Gln Thr Leu Val Ala Ala Ala Asp Arg Asp Ala Val Pro 
    530                 535                 540                 


Val Asp Thr Val Ser His Thr Gly Val Ser Val Val His Ala Lys Cys 
545                 550                 555                 560 


Gly His Glu Asn Pro Ser Asp Gly Arg Phe Met Ser Val Val Val Ala 
                565                 570                 575     


Cys Asp Gly Cys Gly Glu Lys Tyr Asp Gln Asp Glu Ser Ala Leu Thr 
            580                 585                 590         


His Met Leu Thr Arg Ala Val Gln Ser Ala Ala 
        595                 600             


<210> 11
<211> 596
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Thr Thr Met Thr Val His Thr Met Gly Val His Tyr Lys Trp Gln 
1               5                   10                  15      


Ile Pro Glu Val Leu Arg Gln Gln Leu Trp Leu Ala His Asn Leu Arg 
            20                  25                  30          


Glu Asp Leu Val Ser Leu Gln Leu Ala Tyr Asp Asp Asp Leu Lys Ala 
        35                  40                  45              


Ile Trp Ser Ser Tyr Pro Asp Val Ala Gln Ala Glu Asp Thr Met Ala 
    50                  55                  60                  


Ala Ala Glu Ala Asp Ala Val Ala Leu Ser Glu Arg Val Lys Gln Ala 
65                  70                  75                  80  


Arg Ile Glu Ala Arg Ser Lys Lys Ile Ser Thr Glu Leu Thr Gln Gln 
                85                  90                  95      


Leu Arg Asp Ala Lys Lys Arg Leu Lys Asp Ala Arg Gln Ala Arg Arg 
            100                 105                 110         


Asp Ala Ile Ala Val Val Lys Asp Asp Ala Ala Glu Arg Arg Lys Ala 
        115                 120                 125             


Arg Ser Asp Gln Leu Ala Ala Asp Gln Lys Ala Leu Tyr Gly Gln Tyr 
    130                 135                 140                 


Cys Arg Asp Gly Asp Leu Tyr Trp Ala Ser Phe Asn Thr Val Leu Asp 
145                 150                 155                 160 


His His Lys Thr Ala Val Lys Arg Ile Ala Ala Gln Arg Ala Ser Gly 
                165                 170                 175     


Lys Pro Ala Thr Leu Arg His His Arg Phe Asp Gly Ser Gly Thr Ile 
            180                 185                 190         


Ala Val Gln Leu Gln Arg Gln Ala Gly Ala Pro Pro Arg Thr Pro Met 
        195                 200                 205             


Val Leu Ala Asp Glu Ala Gly Lys Tyr Arg Asn Val Leu His Ile Pro 
    210                 215                 220                 


Gly Trp Thr Asp Pro Asp Val Trp Glu Gln Met Thr Arg Ser Gln Cys 
225                 230                 235                 240 


Arg Gln Ser Gly Arg Val Thr Val Arg Met Arg Cys Gly Ser Thr Asp 
                245                 250                 255     


Gly Gln Pro Gln Trp Ile Asp Leu Pro Val Gln Val His Arg Trp Leu 
            260                 265                 270         


Pro Ala Asp Ala Asp Ile Thr Gly Ala Glu Leu Val Val Thr Arg Val 
        275                 280                 285             


Ala Gly Ile Tyr Arg Ala Lys Leu Cys Val Thr Ala Arg Ile Gly Asp 
    290                 295                 300                 


Thr Glu Pro Val Thr Ser Gly Pro Thr Val Ala Leu His Leu Gly Trp 
305                 310                 315                 320 


Arg Ser Thr Glu Glu Gly Thr Ala Val Ala Thr Trp Arg Ser Asp Ala 
                325                 330                 335     


Pro Leu Asp Ile Pro Phe Gly Leu Arg Thr Val Met Arg Val Asp Ala 
            340                 345                 350         


Ala Gly Thr Ser Gly Ile Ile Val Val Pro Ala Thr Ile Glu Arg Arg 
        355                 360                 365             


Leu Thr Arg Thr Glu Asn Ile Ala Ser Ser Arg Ser Leu Ala Leu Asp 
    370                 375                 380                 


Ala Leu Arg Asp Lys Val Val Gly Trp Leu Ser Asp Asn Asp Ala Pro 
385                 390                 395                 400 


Thr Tyr Arg Asp Ala Pro Leu Glu Ala Ala Thr Val Lys Gln Trp Lys 
                405                 410                 415     


Ser Pro Gln Arg Phe Ala Ser Leu Ala His Ala Trp Lys Asp Asn Gly 
            420                 425                 430         


Thr Glu Ile Ser Asp Ile Leu Trp Ala Trp Phe Ser Leu Asp Arg Lys 
        435                 440                 445             


Gln Trp Ala Gln Gln Glu Asn Gly Arg Arg Lys Ala Leu Gly His Arg 
    450                 455                 460                 


Asp Asp Leu Tyr Arg Gln Ile Ala Ala Val Ile Ser Asp Gln Ala Gly 
465                 470                 475                 480 


His Val Leu Val Asp Asp Thr Ser Val Ala Glu Leu Ser Ala Arg Ala 
                485                 490                 495     


Met Glu Arg Thr Glu Leu Pro Thr Glu Val Gln Gln Lys Ile Asp Arg 
            500                 505                 510         


Arg Arg Asp His Ala Ala Pro Gly Gly Leu Arg Ala Ser Val Val Ala 
        515                 520                 525             


Ala Met Thr Arg Asp Gly Val Pro Val Thr Ile Val Ala Ala Ala Asp 
    530                 535                 540                 


Phe Thr Arg Thr His Ser Arg Cys Gly His Val Asn Pro Ala Asp Asp 
545                 550                 555                 560 


Arg Tyr Leu Ser Asn Pro Val Arg Cys Asp Gly Cys Gly Ala Met Tyr 
                565                 570                 575     


Asp Gln Asp Arg Ser Phe Val Thr Leu Met Leu Arg Ala Ala Thr Ala 
            580                 585                 590         


Pro Ser Asn Pro 
        595     


<210> 12
<211> 591
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Met Pro Asp Gln Leu Thr Gln Gln Leu Arg Leu Ala His Asp Leu Arg 
1               5                   10                  15      


Glu Asp Leu Val Thr Leu Glu Tyr Glu Tyr Glu Asp Ala Val Lys Ala 
            20                  25                  30          


Val Trp Ser Ser Tyr Pro Ala Val Ala Ala Leu Glu Ala Gln Val Ala 
        35                  40                  45              


Glu Leu Asp Glu Arg Ala Ser Glu Leu Ala Ser Thr Val Lys Glu Glu 
    50                  55                  60                  


Lys Ser Arg Gln Arg Thr Lys Arg Pro Ser His Pro Ala Val Ala Gln 
65                  70                  75                  80  


Leu Ala Glu Thr Arg Ala Gln Leu Lys Ala Ala Lys Ala Ser Arg Arg 
                85                  90                  95      


Glu Ala Ile Ala Ser Val Arg Asp Glu Ala Thr Glu Arg Leu Arg Thr 
            100                 105                 110         


Ile Ser Asp Glu Arg Tyr Ala Ala Gln Lys Gln Leu Tyr Arg Asp Tyr 
        115                 120                 125             


Cys Thr Asp Gly Leu Leu Tyr Trp Ala Thr Phe Asn Ala Val Leu Asp 
    130                 135                 140                 


His His Lys Thr Ala Val Lys Arg Ile Ala Ala His Arg Lys Gln Gly 
145                 150                 155                 160 


Arg Ala Ala Gln Leu Arg His His Arg Trp Asp Gly Thr Gly Thr Ile 
                165                 170                 175     


Ser Val Gln Leu Gln Arg Gln Ala Thr Asp Pro Ala Arg Thr Pro Ala 
            180                 185                 190         


Ile Ile Ala Asp Ala Asp Thr Gly Lys Trp Arg Ser Ser Leu Ile Val 
        195                 200                 205             


Pro Trp Val Asn Pro Asp Val Trp Asp Thr Met Asp Arg Ala Ser Arg 
    210                 215                 220                 


Arg Lys Ala Gly Arg Val Val Ile Arg Met Arg Cys Gly Ser Ser Arg 
225                 230                 235                 240 


Asn Pro Asp Gly Thr Lys Thr Ser Glu Trp Ile Asp Val Pro Val Gln 
                245                 250                 255     


Gln His Arg Met Leu Pro Ala Asp Ala Asp Ile Thr Ala Ala Gln Leu 
            260                 265                 270         


Thr Val Arg Arg Glu Gly Ala Asp Leu Arg Ala Thr Ile Gly Ile Thr 
        275                 280                 285             


Ala Lys Ile Pro Asp Gln Gly Glu Val Asp Glu Gly Pro Thr Ile Ala 
    290                 295                 300                 


Val His Leu Gly Trp Arg Ser Ser Asp His Gly Thr Val Val Ala Thr 
305                 310                 315                 320 


Trp Arg Ser Thr Glu Pro Leu Asp Ile Pro Glu Thr Leu Arg Gly Val 
                325                 330                 335     


Ile Thr Thr Gln Ser Ala Glu Arg Thr Val Gly Ser Ile Val Val Pro 
            340                 345                 350         


His Arg Ile Glu Gln Arg Val His His His Ala Thr Val Ala Ser His 
        355                 360                 365             


Arg Asp Leu Ala Val Asp Ser Ile Arg Asp Thr Leu Val Ala Trp Leu 
    370                 375                 380                 


Thr Glu His Gly Pro Gln Pro His Pro Tyr Asp Gly Asp Pro Ile Thr 
385                 390                 395                 400 


Ala Ala Ser Val Gln Arg Trp Lys Ala Pro Arg Arg Phe Ala Trp Leu 
                405                 410                 415     


Ala Leu Gln Trp Arg Asp Thr Pro Pro Pro Glu Gly Ala Asp Ile Ala 
            420                 425                 430         


Glu Thr Leu Glu Ala Trp Arg Arg Ala Asp Lys Lys Leu Trp Leu Glu 
        435                 440                 445             


Ser Glu His Gly Arg Gly Arg Ala Leu Arg His Arg Thr Asp Leu His 
    450                 455                 460                 


Arg Gln Val Ala Ala Tyr Phe Ala Gly Val Ala Gly Arg Ile Val Val 
465                 470                 475                 480 


Asp Asp Ser Asp Ile Ala Gln Ile Ala Gly Thr Ala Lys His Ser Glu 
                485                 490                 495     


Leu Leu Thr Asp Val Asp Arg Gln Ile Ala Arg Arg Arg Ala Ile Ala 
            500                 505                 510         


Ala Pro Gly Met Leu Arg Ala Ala Ile Val Ala Ala Ala Thr Arg Asp 
        515                 520                 525             


Glu Val Pro Thr Thr Thr Val Ser His Thr Gly Leu Ser Arg Val His 
    530                 535                 540                 


Ala Ala Cys Gly His Glu Asn Pro Ala Asp Asp Arg Tyr Leu Met Gln 
545                 550                 555                 560 


Pro Val Leu Cys Asp Gly Cys Gly Arg Thr Tyr Asp Thr Asp Leu Ser 
                565                 570                 575     


Ala Thr Ile Leu Met Leu Gln Arg Ala Ser Ala Ala Thr Ser Asn 
            580                 585                 590     


<210> 13
<211> 415
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Met Leu Arg Ala Tyr Lys Tyr Arg Ile Tyr Pro Thr Asp Glu Gln Lys 
1               5                   10                  15      


Val Leu Phe Ala Lys Thr Phe Gly Cys Cys Arg Phe Val Tyr Asn Trp 
            20                  25                  30          


Ala Leu Asn Leu Lys Ile Thr Ala Tyr Lys Glu Arg Lys Glu Thr Leu 
        35                  40                  45              


Gly Asn Val Tyr Leu Thr Asn Leu Met Lys Ser Glu Leu Lys Val Glu 
    50                  55                  60                  


His Glu Trp Leu Ser Glu Val Asn Ser Gln Ser Leu Gln Ser Ser Leu 
65                  70                  75                  80  


Arg Asn Leu Asp Thr Ala Tyr Thr Asn Phe Phe Arg Asn Thr Lys Ala 
                85                  90                  95      


Val Gly Phe Pro Arg Phe Lys Ser Arg Lys Asp Lys Gln Ser Phe Leu 
            100                 105                 110         


Cys Pro Gln His Cys Arg Val Asp Phe Glu Lys Gly Thr Ile Thr Ile 
        115                 120                 125             


Pro Lys Ala Lys Asp Ile Pro Ala Val Leu His Arg Arg Phe Lys Gly 
    130                 135                 140                 


Thr Val Lys Thr Val Thr Ile Ser Met Thr Pro Ser Gly Arg Tyr Phe 
145                 150                 155                 160 


Ala Ser Val Leu Val Asp Thr Ser Met Gln Glu Met Lys Pro Ser Glu 
                165                 170                 175     


Pro Met Arg Asp Thr Thr Val Gly Ile Asp Leu Gly Ile Lys Ser Leu 
            180                 185                 190         


Ala Val Cys Ser Asp Gly Arg Thr Phe Ala Asn Pro Lys Asn Leu Gln 
        195                 200                 205             


Arg Ser Leu Asp Arg Leu Lys Leu Leu Gln Lys Arg Leu Ser Arg Lys 
    210                 215                 220                 


Gln Lys Gly Ser Ala Asn Arg Asn Lys Ala Arg Ile Arg Val Ala Arg 
225                 230                 235                 240 


Leu Gln Glu His Ile Ala Asn Ser Arg Lys Asp Ser Leu His Lys Ile 
                245                 250                 255     


Thr His Ala Leu Thr His Asp Ser Gln Val Arg Thr Ile Cys Met Glu 
            260                 265                 270         


Asp Leu Asn Val Lys Gly Met Gln Arg Asn His His Leu Ala Gln Ala 
        275                 280                 285             


Val Gly Asp Ala Ser Phe Gly Met Phe Leu Thr Leu Leu Glu Tyr Lys 
    290                 295                 300                 


Cys Ser Trp Tyr Gly Val Asn Leu Ile Lys Ile Asp Arg Phe Ala Pro 
305                 310                 315                 320 


Ser Ser Lys Thr Cys Gly Lys Cys Gly His Val Tyr Lys Gly Leu Asn 
                325                 330                 335     


Leu Ser Glu Arg Ser Trp Thr Cys Pro Glu Cys Gly Thr His His Asp 
            340                 345                 350         


Arg Asp Phe Asn Ala Ala Cys Asn Ile Lys Glu Phe Gly Leu Lys Ala 
        355                 360                 365             


Leu Pro Thr Glu Arg Gly Lys Val Lys Pro Val Asp Cys Pro Leu Val 
    370                 375                 380                 


Asp Asp Arg Pro Arg Val Leu Lys Ser Asn Gly Arg Lys Lys Gln Glu 
385                 390                 395                 400 


Lys Arg Gly Gly Ile Gly Ile Ser Glu Ala Ala Lys Ser Leu Val 
                405                 410                 415 


<210> 14
<211> 300
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Pro Gln Gly Ile Lys Phe Asp Lys Glu Asn Asn Lys Val Lys Ile Thr 
1               5                   10                  15      


Ile Ala Lys Asn Leu Pro Lys Glu Phe Ile Phe Ser Gly Thr Asn Val 
            20                  25                  30          


Ala Asn Lys His Gly Arg Arg Phe Phe Lys Glu Lys Leu Asn Leu Ile 
        35                  40                  45              


Ser Gln Gln Lys Pro Lys Tyr Ala Tyr Leu Ile Arg Lys Gln Thr Lys 
    50                  55                  60                  


Asn Ser Lys Lys Ile Thr Asp Tyr Asp Tyr Tyr Leu Gln Tyr Thr Ile 
65                  70                  75                  80  


Glu Thr Val Tyr Lys Ile Arg Lys Asn Tyr Asp Gly Ile Ile Gly Ile 
                85                  90                  95      


Asp Arg Gly Ile Asn Asn Leu Ala Cys Leu Val Leu Leu Glu Lys Asn 
            100                 105                 110         


Gln Glu Lys Pro Cys Gly Val Lys Phe Tyr Lys Gly Lys Glu Ile Asn 
        115                 120                 125             


Ala Leu Lys Ile Lys Arg Arg Lys Gln Leu Tyr Phe Leu Arg Arg Lys 
    130                 135                 140                 


His Asn Arg Lys Gln Lys Gln Lys Arg Ile Arg Arg Ile Glu Pro Lys 
145                 150                 155                 160 


Ile Asn Gln Ile Leu His Ile Ile Ser Lys Glu Ile Val Glu Leu Ala 
                165                 170                 175     


Lys Glu Lys Asn Phe Ala Ile Gly Leu Glu Gln Leu Glu Lys Pro Lys 
            180                 185                 190         


Lys Ser Arg Phe Arg Gln Arg Arg Lys Glu Arg Tyr Phe Leu Ser Leu 
        195                 200                 205             


Phe Asn Phe Lys Thr Leu Ser Thr Phe Ile Glu Tyr Lys Ala Lys Lys 
    210                 215                 220                 


Glu Gly Ile Arg Val Ile Tyr Ile Pro Pro Glu Arg Thr Ser Gln Ile 
225                 230                 235                 240 


Cys Ser His Cys Ala Ile Lys Gly Asp Val His Thr Asn Thr Ile Arg 
                245                 250                 255     


Pro Tyr Arg Lys Pro Asn Ala Lys Lys Ser Ser Ser Ser Leu Phe Lys 
            260                 265                 270         


Cys Lys Lys Cys Gly Val Glu Leu Asn Ala Asp Tyr Asn Ala Ala Phe 
        275                 280                 285             


Asn Ile Ala Gln Lys Ser Leu Lys Ile Leu Ser Thr 
    290                 295                 300 


<210> 15
<211> 204
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Asp Arg Gly Ile Asn Asn Leu Ala Cys Leu Val Leu Leu Glu Lys Asn 
1               5                   10                  15      


Gln Glu Lys Pro Cys Gly Val Lys Phe Tyr Lys Gly Lys Glu Ile Asn 
            20                  25                  30          


Ala Leu Lys Ile Lys Arg Arg Lys Gln Leu Tyr Phe Leu Arg Arg Lys 
        35                  40                  45              


His Asn Arg Lys Gln Lys Gln Lys Arg Ile Arg Arg Ile Glu Pro Lys 
    50                  55                  60                  


Ile Asn Gln Ile Leu His Ile Ile Ser Lys Glu Ile Val Glu Leu Ala 
65                  70                  75                  80  


Lys Glu Lys Asn Phe Ala Ile Gly Leu Glu Gln Leu Glu Lys Pro Lys 
                85                  90                  95      


Lys Ser Arg Phe Arg Gln Arg Arg Lys Glu Arg Tyr Phe Leu Ser Leu 
            100                 105                 110         


Phe Asn Phe Lys Thr Leu Ser Thr Phe Ile Glu Tyr Lys Ala Lys Lys 
        115                 120                 125             


Glu Gly Ile Arg Val Ile Tyr Ile Pro Pro Glu Arg Thr Ser Gln Ile 
    130                 135                 140                 


Cys Ser His Cys Ala Ile Lys Gly Asp Val His Thr Asn Thr Ile Arg 
145                 150                 155                 160 


Pro Tyr Arg Lys Pro Asn Ala Lys Lys Ser Ser Ser Ser Leu Phe Lys 
                165                 170                 175     


Cys Lys Lys Cys Gly Val Glu Leu Asn Ala Asp Tyr Asn Ala Ala Phe 
            180                 185                 190         


Asn Ile Ala Gln Lys Ser Leu Lys Ile Leu Ser Thr 
        195                 200                 


<210> 16
<211> 193
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Leu Leu Glu Lys Asn Gln Glu Lys Pro Cys Gly Val Lys Phe Tyr Lys 
1               5                   10                  15      


Gly Lys Glu Ile Asn Ala Leu Lys Ile Lys Arg Arg Lys Gln Leu Tyr 
            20                  25                  30          


Phe Leu Arg Arg Lys His Asn Arg Lys Gln Lys Gln Lys Arg Ile Arg 
        35                  40                  45              


Arg Ile Glu Pro Lys Ile Asn Gln Ile Leu His Ile Ile Ser Lys Glu 
    50                  55                  60                  


Ile Val Glu Leu Ala Lys Glu Lys Asn Phe Ala Ile Gly Leu Glu Gln 
65                  70                  75                  80  


Leu Glu Lys Pro Lys Lys Ser Arg Phe Arg Gln Arg Arg Lys Glu Arg 
                85                  90                  95      


Tyr Phe Leu Ser Leu Phe Asn Phe Lys Thr Leu Ser Thr Phe Ile Glu 
            100                 105                 110         


Tyr Lys Ala Lys Lys Glu Gly Ile Arg Val Ile Tyr Ile Pro Pro Glu 
        115                 120                 125             


Arg Thr Ser Gln Ile Cys Ser His Cys Ala Ile Lys Gly Asp Val His 
    130                 135                 140                 


Thr Asn Thr Ile Arg Pro Tyr Arg Lys Pro Asn Ala Lys Lys Ser Ser 
145                 150                 155                 160 


Ser Ser Leu Phe Lys Cys Lys Lys Cys Gly Val Glu Leu Asn Ala Asp 
                165                 170                 175     


Tyr Asn Ala Ala Phe Asn Ile Ala Gln Lys Ser Leu Lys Ile Leu Ser 
            180                 185                 190         


Thr 
    


<210> 17
<211> 370
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Met Glu Tyr Ser Tyr Lys Phe Arg Val Tyr Pro Thr Ala Ala Gln Ala 
1               5                   10                  15      


Glu Gln Ile Gln Arg Thr Phe Gly Cys Cys Arg Phe Val Trp Asn His 
            20                  25                  30          


Tyr Leu Ala Leu Arg Lys Asp Leu Tyr Glu Gln Asp Gly Lys Thr Met 
        35                  40                  45              


Asn Tyr Asn Ala Cys Ser Gly Asp Met Thr Gln Leu Lys Lys Thr Leu 
    50                  55                  60                  


Leu Trp Leu Arg Glu Val Asp Ala Thr Ala Leu Gln Ser Ser Leu Arg 
65                  70                  75                  80  


Asp Leu Asp Thr Ala Tyr Gln Asn Phe Phe Arg Arg Val Lys Lys Gly 
                85                  90                  95      


Glu Lys Pro Gly Tyr Pro Lys Phe Lys Ser Lys His His Ser Lys Lys 
            100                 105                 110         


Ser Tyr Lys Ser Lys Cys Val Gly Thr Asn Ile Lys Val Leu Asp Lys 
        115                 120                 125             


Ala Val Gln Leu Pro Lys Leu Gly Leu Val Lys Cys Arg Ile Ser Lys 
    130                 135                 140                 


Glu Val Lys Gly Arg Ile Leu Ser Ala Thr Ile Ser Gln Asn Pro Ser 
145                 150                 155                 160 


Gly Lys Tyr Phe Val Ala Ile Cys Cys Thr Asp Val Glu Leu Glu Pro 
                165                 170                 175     


Leu Thr Ser Thr Gly Ala Val Ala Gly Ile Asp Met Gly Leu Lys Ala 
            180                 185                 190         


Phe Ala Ile Thr Ser Asp Gly Val Glu Tyr Pro Asn His Lys Tyr Leu 
        195                 200                 205             


Thr Lys Ser Gln Lys Lys Leu Ala Lys Leu Gln Arg Gln Leu Ser Arg 
    210                 215                 220                 


Lys Ser Lys Gly Ser Lys Arg Arg Glu Lys Ala Arg Ile Gln Val Ala 
225                 230                 235                 240 


Arg Leu His Glu His Val Ala Asn Gln Arg Gln Asp Met Leu His Lys 
                245                 250                 255     


Leu Ser Thr Asp Leu Val Arg Asn Tyr Asp Leu Ile Ala Ile Glu Asp 
            260                 265                 270         


Leu Ala Pro Ser Asn Met Val Lys Asn His Met Leu Ala Lys Ala Ile 
        275                 280                 285             


Ser Asp Ala Ser Trp Gly Glu Phe Pro Arg Gln Leu Lys Tyr Lys Ala 
    290                 295                 300                 


Glu Trp His Gly Lys Lys Val Val Thr Val Gly Arg Phe Phe Pro Ser 
305                 310                 315                 320 


Ser Gln Leu Cys Ser Asn Cys Gly Ala Gln Trp Ser Gly Thr Lys Asp 
                325                 330                 335     


Leu Ser Val Arg Gln Trp Thr Cys Pro Val Cys Gly Ala Ile His Asp 
            340                 345                 350         


Arg Asp Met Asn Ala Ala Arg Asn Ile Leu Asn Glu Gly Leu Arg Leu 
        355                 360                 365             


Met Ala 
    370 


<210> 18
<211> 371
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Val Tyr Asn Tyr Phe Leu Ser Gln Arg Lys Glu Gln Tyr Arg Leu Thr 
1               5                   10                  15      


Gly Lys Ser Asp Asn Tyr Tyr Ala Gln Ala Lys Thr Leu Thr Ala Leu 
            20                  25                  30          


Lys Lys Gln Glu Glu Thr Ala Trp Leu Lys Glu Val Asn Ala Gln Thr 
        35                  40                  45              


Leu Gln Phe Ala Ile Lys Ser Leu Glu Ser Ala Tyr Thr Asn Phe Phe 
    50                  55                  60                  


Lys Lys Ser Ala Lys Phe Pro Lys Phe Lys Ser Lys His Ser Lys Asn 
65                  70                  75                  80  


Ser Phe Thr Val Pro Gln Ser Ala Ser Val Ala Gly Gly Arg Leu Phe 
                85                  90                  95      


Ile Pro Lys Phe Thr Glu Gly Ile Lys Cys Ser Val His Arg Glu Ile 
            100                 105                 110         


Lys Gly Lys Ile Gly Lys Val Thr Ile Thr Lys Ser Pro Ser Gly Lys 
        115                 120                 125             


Tyr Phe Val Ser Val Phe Thr Glu Glu Glu Tyr Ile Thr Gln Leu Glu 
    130                 135                 140                 


Lys Thr Gly Lys Ser Ile Gly Leu Asp Met Gly Leu Lys Asp Leu Leu 
145                 150                 155                 160 


Ile Thr Ser Glu Gly Glu Ile Phe Asn Asn Asn Arg Tyr Thr Arg Arg 
                165                 170                 175     


Tyr Glu Cys Lys Leu Ala Lys Ala Gln Arg His Leu Ser Arg Lys Lys 
            180                 185                 190         


Lys Gly Ser Arg Gly Phe Glu Asn Gln Arg Leu Lys Val Ala Arg Leu 
        195                 200                 205             


His Glu Lys Ile Val Asn Ser Arg Thr Asp Tyr Leu His Lys Cys Ser 
    210                 215                 220                 


Ile Ser Leu Val Arg Arg Tyr Asp Ile Ile Cys Ile Glu Asp Leu Asn 
225                 230                 235                 240 


Val Lys Gly Met Thr Lys Asn His His Leu Ala Lys Ser Ile Thr Asp 
                245                 250                 255     


Ala Ser Trp Gly Lys Phe Val Ser Met Leu Thr Tyr Lys Ala Glu Trp 
            260                 265                 270         


Asn Asn Lys Lys Val Val Asp Val Asp Arg Tyr Phe Pro Ser Ser Gln 
        275                 280                 285             


Thr Cys Asn Val Cys Gly Tyr Val Asn Lys Gln Ile Lys Asp Leu Ser 
    290                 295                 300                 


Val Arg Glu Trp Glu Cys Pro His Cys His Thr His His Asp Arg Asp 
305                 310                 315                 320 


Lys Asn Ala Ala Ile Asn Ile Leu Arg Ile Gly Leu Asn Asn Asn Ile 
                325                 330                 335     


Ser Ala Gly Thr Val Asp Tyr Thr Gly Gly Glu Glu Val Arg Thr Asp 
            340                 345                 350         


Leu Leu Glu Ser His Ser Ser Val Lys Pro Glu Ala Asn Glu Pro Leu 
        355                 360                 365             


Val His Gly 
    370     


<210> 19
<211> 382
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Met Leu Ala Lys His Phe Gly Cys Ser Arg Phe Val Tyr Asn Tyr Phe 
1               5                   10                  15      


Leu Ser Gln Arg Lys Glu Gln Tyr Arg Leu Thr Gly Lys Ser Asp Asn 
            20                  25                  30          


Tyr Tyr Ala Gln Ala Lys Thr Leu Thr Ala Leu Lys Lys Gln Glu Glu 
        35                  40                  45              


Thr Ala Trp Leu Lys Glu Val Asn Ala Gln Thr Leu Gln Phe Ala Ile 
    50                  55                  60                  


Lys Ser Leu Glu Ser Ala Tyr Thr Asn Phe Phe Lys Lys Ser Ala Lys 
65                  70                  75                  80  


Phe Pro Lys Phe Lys Ser Lys His Ser Lys Asn Ser Phe Thr Val Pro 
                85                  90                  95      


Gln Ser Ala Ser Val Ala Gly Gly Arg Leu Phe Ile Pro Lys Phe Thr 
            100                 105                 110         


Glu Gly Ile Lys Cys Ser Val His Arg Glu Ile Lys Gly Lys Ile Gly 
        115                 120                 125             


Lys Val Thr Ile Thr Lys Ser Pro Ser Gly Lys Tyr Phe Val Ser Val 
    130                 135                 140                 


Phe Thr Glu Glu Glu Tyr Ile Thr Gln Leu Glu Lys Thr Gly Lys Ser 
145                 150                 155                 160 


Ile Gly Leu Asp Met Gly Leu Lys Asp Leu Leu Ile Thr Ser Glu Gly 
                165                 170                 175     


Glu Ile Phe Asn Asn Asn Arg Tyr Thr Arg Arg Tyr Glu Cys Lys Leu 
            180                 185                 190         


Ala Lys Ala Gln Arg His Leu Ser Arg Lys Lys Lys Gly Ser Arg Gly 
        195                 200                 205             


Phe Glu Asn Gln Arg Leu Lys Val Ala Arg Leu His Glu Lys Ile Val 
    210                 215                 220                 


Asn Ser Arg Thr Asp Tyr Leu His Lys Cys Ser Ile Ser Leu Val Arg 
225                 230                 235                 240 


Arg Tyr Asp Ile Ile Cys Ile Glu Asp Leu Asn Val Lys Gly Met Thr 
                245                 250                 255     


Lys Asn His His Leu Ala Lys Ser Ile Thr Asp Ala Ser Trp Gly Lys 
            260                 265                 270         


Phe Val Ser Met Leu Thr Tyr Lys Ala Glu Trp Asn Asn Lys Lys Val 
        275                 280                 285             


Val Asp Val Asp Arg Tyr Phe Pro Ser Ser Gln Thr Cys Asn Val Cys 
    290                 295                 300                 


Gly Tyr Val Asn Lys Gln Ile Lys Asp Leu Ser Val Arg Glu Trp Glu 
305                 310                 315                 320 


Cys Pro His Cys His Thr His His Asp Arg Asp Lys Asn Ala Ala Ile 
                325                 330                 335     


Asn Ile Leu Arg Ile Gly Leu Asn Asn Asn Ile Ser Ala Gly Thr Val 
            340                 345                 350         


Asp Tyr Thr Gly Gly Glu Glu Val Arg Thr Asp Leu Leu Glu Ser His 
        355                 360                 365             


Ser Ser Val Lys Pro Glu Ala Asn Glu Pro Leu Val His Gly 
    370                 375                 380         


<210> 20
<211> 144
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 20
gattgtatta tgctccactt taataagtgg tgccttccaa agctatatgc tgagggagga       60

tgggcgctgt tgcagcgtct gcccacctca gagtgggtat ccttacctat tgaaaaccca      120

aagtaatagg tcaaggaatg caac                                             144


<210> 21
<211> 138
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 21
gattgtatta tgctccactt taataagtgg tgccttccaa agctatatgc tgagggagga       60

tgggcgctgt tgcagcgtct gcccacctca gagtgggtat ccttacctat tgaaaagtaa      120

taggtcaagg aatgcaac                                                    138


<210> 22
<211> 135
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 22
gattgtatta tgctccactt taataagtgg tgccttccaa agctatatgc tgagggagga       60

tgggcgctgt tgcagcgtct gcccacctca gagtgggtat ccttacctat tgaaaaatag      120

gtcaaggaat gcaac                                                       135


<210> 23
<211> 136
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 23
gattgtatta tgctccactt taataagtgg tgccttccaa agctatatgc tgagggagga       60

tgggcgctgt tgcagcgtct gcccacctca gagtgggtat ccttacctat tgaaataata      120

ggtcaaggaa tgcaac                                                      136


<210> 24
<211> 128
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 24
gctttaataa gtggtgcctt ccaaagctat atgctgaggg aggatgggcg ctgttgcagc       60

gtctgcccac ctcagagtgg gtatccttac ctattgaaaa cccaaagtaa taggtcaagg      120

aatgcaac                                                               128


<210> 25
<211> 122
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 25
gctttaataa gtggtgcctt ccaaagctat atgctgaggg aggatgggcg ctgttgcagc       60

gtctgcccac ctcagagtgg gtatccttac ctattgaaaa gtaataggtc aaggaatgca      120

ac                                                                     122


<210> 26
<211> 119
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 26
gctttaataa gtggtgcctt ccaaagctat atgctgaggg aggatgggcg ctgttgcagc       60

gtctgcccac ctcagagtgg gtatccttac ctattgaaaa ataggtcaag gaatgcaac       119


<210> 27
<211> 120
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 27
gctttaataa gtggtgcctt ccaaagctat atgctgaggg aggatgggcg ctgttgcagc       60

gtctgcccac ctcagagtgg gtatccttac ctattgaaat aataggtcaa ggaatgcaac      120


<210> 28
<211> 116
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 28
ggtgccttcc aaagctatat gctgagggag gatgggcgct gttgcagcgt ctgcccacct       60

cagagtgggt atccttacct attgaaaacc caaagtaata ggtcaaggaa tgcaac          116


<210> 29
<211> 110
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 29
ggtgccttcc aaagctatat gctgagggag gatgggcgct gttgcagcgt ctgcccacct       60

cagagtgggt atccttacct attgaaaagt aataggtcaa ggaatgcaac                 110


<210> 30
<211> 107
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 30
ggtgccttcc aaagctatat gctgagggag gatgggcgct gttgcagcgt ctgcccacct       60

cagagtgggt atccttacct attgaaaaat aggtcaagga atgcaac                    107


<210> 31
<211> 108
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 31
ggtgccttcc aaagctatat gctgagggag gatgggcgct gttgcagcgt ctgcccacct       60

cagagtgggt atccttacct attgaaataa taggtcaagg aatgcaac                   108


<210> 32
<211> 113
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 32
gccttccaaa gctatatgct gagggaggat gggcgctgtt gcagcgtctg cccacctcag       60

agtgggtatc cttacctatt gaaaacccaa agtaataggt caaggaatgc aac             113


<210> 33
<211> 107
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 33
gccttccaaa gctatatgct gagggaggat gggcgctgtt gcagcgtctg cccacctcag       60

agtgggtatc cttacctatt gaaaagtaat aggtcaagga atgcaac                    107


<210> 34
<211> 105
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 34
gccttccaaa gctatatgct gagggaggat gggcgctgtt gcagcgtctt gcccacctca       60

gagtgggtat ccttacctat tgaaaaatag gtcaaggaat gcaac                      105


<210> 35
<211> 107
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 35
gccttccaaa gctatatgct gagggaggat gggcgctgtt gcagcgtctg ccccacctca       60

gagtgggtat ccttacctat tgaaataata ggtcaaggaa ttgcaac                    107


<210> 36
<211> 115
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 36
gtgccttcca aagctatatg ctgagggagg atgggcgctg ttgcagcgtc tgcccacctc       60

agagtgggta tccttaccta ttgaaaaccc aaagtaatag gtcaaggaat gcaac           115


<210> 37
<211> 109
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 37
gtgccttcca aagctatatg ctgagggagg atgggcgctg ttgcagcgtc tgcccacctc       60

agagtgggta tccttaccta ttgaaaagta ataggtcaag gaatgcaac                  109


<210> 38
<211> 106
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 38
gtgccttcca aagctatatg ctgagggagg atgggcgctg ttgcagcgtc tgcccacctc       60

agagtgggta tccttaccta ttgaaaaata ggtcaaggaa tgcaac                     106


<210> 39
<211> 107
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 39
gtgccttcca aagctatatg ctgagggagg atgggcgctg ttgcagcgtc tgcccacctc       60

agagtgggta tccttaccta ttgaaataat aggtcaagga atgcaac                    107


<210> 40
<211> 132
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 40
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg aaaacccaaa gtaataggtc      120

aaggaatgca ac                                                          132


<210> 41
<211> 126
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 41
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg aaaagtaata ggtcaaggaa      120

tgcaac                                                                 126


<210> 42
<211> 123
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 42
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg aaaaataggt caaggaatgc      120

aac                                                                    123


<210> 43
<211> 124
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 43
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg aaataatagg tcaaggaatg      120

caac                                                                   124


<210> 44
<211> 599
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Glu Gly Ala Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Met Pro Ser 
1               5                   10                  15      


Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile Pro Ser Asp 
            20                  25                  30          


Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe Gln Arg Ala 
        35                  40                  45              


Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser Ser Phe Arg 
    50                  55                  60                  


Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp Cys Cys Gly 
65                  70                  75                  80  


Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys Thr Phe Lys 
                85                  90                  95      


Phe Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys Asp Ile Tyr 
            100                 105                 110         


Thr Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr Ser Gly Val 
        115                 120                 125             


Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn Asp Lys Glu 
    130                 135                 140                 


Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn Ala Pro Gly 
145                 150                 155                 160 


Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile Ser Ile 
                165                 170                 175     


Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg Ile Ile 
            180                 185                 190         


Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp Asp Val 
        195                 200                 205             


Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu Gly His 
    210                 215                 220                 


Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu Lys Trp Gln 
225                 230                 235                 240 


Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu Lys 
                245                 250                 255     


Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg Pro 
            260                 265                 270         


Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr Glu Thr 
        275                 280                 285             


Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala Ser 
    290                 295                 300                 


Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser Ile 
305                 310                 315                 320 


Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu Glu 
                325                 330                 335     


Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln Tyr 
            340                 345                 350         


Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe Lys 
        355                 360                 365             


Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys Ile 
    370                 375                 380                 


Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe His 
385                 390                 395                 400 


Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg Asp 
                405                 410                 415     


Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys Lys 
            420                 425                 430         


Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val Lys 
        435                 440                 445             


Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val Glu 
    450                 455                 460                 


Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu Arg 
465                 470                 475                 480 


Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys Ala 
                485                 490                 495     


Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu Ile 
            500                 505                 510         


Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met Ile 
        515                 520                 525             


Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr Val 
    530                 535                 540                 


Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys Gly 
545                 550                 555                 560 


Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys Ala 
                565                 570                 575     


Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala Tyr 
            580                 585                 590         


Val Cys Ser Glu Pro Asp Lys 
        595                 


<210> 45
<211> 596
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Met Pro Ser Glu Thr Tyr 
1               5                   10                  15      


Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile Pro Ser Asp Glu Glu Lys 
            20                  25                  30          


Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe Gln Arg Ala Val Asn Phe 
        35                  40                  45              


Ala Ile Asp Arg Ile Val Asp Ile Arg Ser Ser Phe Arg Tyr Leu Asn 
    50                  55                  60                  


Lys Asn Glu Gln Phe Pro Ala Val Cys Asp Cys Cys Gly Lys Lys Glu 
65                  70                  75                  80  


Lys Ile Met Tyr Val Asn Ile Ser Asn Lys Thr Phe Lys Phe Lys Pro 
                85                  90                  95      


Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys Asp Ile Tyr Thr Ile Lys 
            100                 105                 110         


Pro Asn Ala His Ile Cys Lys Thr Cys Tyr Ser Gly Val Ala Gly Asn 
        115                 120                 125             


Met Phe Ile Arg Lys Gln Met Tyr Pro Asn Asp Lys Glu Gly Trp Lys 
    130                 135                 140                 


Val Ser Arg Ser Tyr Asn Ile Lys Val Asn Ala Pro Gly Leu Thr Gly 
145                 150                 155                 160 


Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile Ser Ile Leu Arg Ser 
                165                 170                 175     


Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg Ile Ile Glu Tyr Glu 
            180                 185                 190         


Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp Asp Val Glu Lys Gly 
        195                 200                 205             


Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu Gly His Gln Arg Val 
    210                 215                 220                 


Lys Arg Tyr Lys His Lys Asn Trp Pro Glu Lys Trp Gln Gly Ile Ser 
225                 230                 235                 240 


Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu Lys Arg Ile Lys 
                245                 250                 255     


Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg Pro Tyr Val Glu 
            260                 265                 270         


Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr Glu Thr Val Glu Leu 
        275                 280                 285             


Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala Ser Ile Ser Asn 
    290                 295                 300                 


Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser Ile Glu Tyr Leu 
305                 310                 315                 320 


Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu Glu Thr Tyr Pro 
                325                 330                 335     


Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln Tyr Pro Val Arg 
            340                 345                 350         


Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe Lys Ala Phe Gly 
        355                 360                 365             


Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys Ile Ile Ser Lys 
    370                 375                 380                 


Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe His Gly Lys Glu 
385                 390                 395                 400 


Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg Asp Arg Leu Tyr 
                405                 410                 415     


Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys Lys Ile Arg Leu 
            420                 425                 430         


Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val Lys Tyr Phe Arg 
        435                 440                 445             


Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val Glu Ile Ala Lys 
    450                 455                 460                 


Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu Arg Tyr Leu Arg 
465                 470                 475                 480 


Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys Ala Lys Lys Thr 
                485                 490                 495     


Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu Ile Asp Met Ile 
            500                 505                 510         


Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met Ile Ile Asp Pro 
        515                 520                 525             


Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr Val Asp Glu Asn 
    530                 535                 540                 


Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys Gly Tyr Ser Leu 
545                 550                 555                 560 


Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys Ala Phe Tyr Glu 
                565                 570                 575     


Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala Tyr Val Cys Ser 
            580                 585                 590         


Glu Pro Asp Lys 
        595     


<210> 46
<211> 598
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Met Pro Ser Glu 
1               5                   10                  15      


Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile Pro Ser Asp Glu 
            20                  25                  30          


Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe Gln Arg Ala Val 
        35                  40                  45              


Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser Ser Phe Arg Tyr 
    50                  55                  60                  


Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp Cys Cys Gly Lys 
65                  70                  75                  80  


Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys Thr Phe Lys Phe 
                85                  90                  95      


Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys Asp Ile Tyr Thr 
            100                 105                 110         


Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr Ser Gly Val Ala 
        115                 120                 125             


Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn Asp Lys Glu Gly 
    130                 135                 140                 


Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn Ala Pro Gly Leu 
145                 150                 155                 160 


Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile Ser Ile Leu 
                165                 170                 175     


Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg Ile Ile Glu 
            180                 185                 190         


Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp Asp Val Glu 
        195                 200                 205             


Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu Gly His Gln 
    210                 215                 220                 


Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu Lys Trp Gln Gly 
225                 230                 235                 240 


Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu Lys Arg 
                245                 250                 255     


Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg Pro Tyr 
            260                 265                 270         


Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr Glu Thr Val 
        275                 280                 285             


Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala Ser Ile 
    290                 295                 300                 


Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser Ile Glu 
305                 310                 315                 320 


Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu Glu Thr 
                325                 330                 335     


Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln Tyr Pro 
            340                 345                 350         


Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe Lys Ala 
        355                 360                 365             


Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys Ile Ile 
    370                 375                 380                 


Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe His Gly 
385                 390                 395                 400 


Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg Asp Arg 
                405                 410                 415     


Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys Lys Ile 
            420                 425                 430         


Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val Lys Tyr 
        435                 440                 445             


Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val Glu Ile 
    450                 455                 460                 


Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu Arg Tyr 
465                 470                 475                 480 


Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys Ala Lys 
                485                 490                 495     


Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu Ile Asp 
            500                 505                 510         


Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met Ile Ile 
        515                 520                 525             


Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr Val Asp 
    530                 535                 540                 


Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys Gly Tyr 
545                 550                 555                 560 


Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys Ala Phe 
                565                 570                 575     


Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala Tyr Val 
            580                 585                 590         


Cys Ser Glu Pro Asp Lys 
        595             


<210> 47
<211> 598
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Lys Leu Lys Ile Lys Arg Pro Val Lys Gly Gly Ser Met Pro Ser Glu 
1               5                   10                  15      


Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile Pro Ser Asp Glu 
            20                  25                  30          


Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe Gln Arg Ala Val 
        35                  40                  45              


Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser Ser Phe Arg Tyr 
    50                  55                  60                  


Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp Cys Cys Gly Lys 
65                  70                  75                  80  


Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys Thr Phe Lys Phe 
                85                  90                  95      


Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys Asp Ile Tyr Thr 
            100                 105                 110         


Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr Ser Gly Val Ala 
        115                 120                 125             


Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn Asp Lys Glu Gly 
    130                 135                 140                 


Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn Ala Pro Gly Leu 
145                 150                 155                 160 


Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile Ser Ile Leu 
                165                 170                 175     


Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg Ile Ile Glu 
            180                 185                 190         


Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp Asp Val Glu 
        195                 200                 205             


Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu Gly His Gln 
    210                 215                 220                 


Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu Lys Trp Gln Gly 
225                 230                 235                 240 


Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu Lys Arg 
                245                 250                 255     


Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg Pro Tyr 
            260                 265                 270         


Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr Glu Thr Val 
        275                 280                 285             


Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala Ser Ile 
    290                 295                 300                 


Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser Ile Glu 
305                 310                 315                 320 


Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu Glu Thr 
                325                 330                 335     


Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln Tyr Pro 
            340                 345                 350         


Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe Lys Ala 
        355                 360                 365             


Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys Ile Ile 
    370                 375                 380                 


Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe His Gly 
385                 390                 395                 400 


Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg Asp Arg 
                405                 410                 415     


Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys Lys Ile 
            420                 425                 430         


Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val Lys Tyr 
        435                 440                 445             


Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val Glu Ile 
    450                 455                 460                 


Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu Arg Tyr 
465                 470                 475                 480 


Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys Ala Lys 
                485                 490                 495     


Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu Ile Asp 
            500                 505                 510         


Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met Ile Ile 
        515                 520                 525             


Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr Val Asp 
    530                 535                 540                 


Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys Gly Tyr 
545                 550                 555                 560 


Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys Ala Phe 
                565                 570                 575     


Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala Tyr Val 
            580                 585                 590         


Cys Ser Glu Pro Asp Lys 
        595             


<210> 48
<211> 609
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Ala Val Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys 
1               5                   10                  15      


Lys Lys Leu Asp Gly Gly Ser Met Pro Ser Glu Thr Tyr Ile Thr Lys 
            20                  25                  30          


Thr Leu Ser Leu Lys Leu Ile Pro Ser Asp Glu Glu Lys Gln Ala Leu 
        35                  40                  45              


Glu Asn Tyr Phe Ile Thr Phe Gln Arg Ala Val Asn Phe Ala Ile Asp 
    50                  55                  60                  


Arg Ile Val Asp Ile Arg Ser Ser Phe Arg Tyr Leu Asn Lys Asn Glu 
65                  70                  75                  80  


Gln Phe Pro Ala Val Cys Asp Cys Cys Gly Lys Lys Glu Lys Ile Met 
                85                  90                  95      


Tyr Val Asn Ile Ser Asn Lys Thr Phe Lys Phe Lys Pro Ser Arg Asn 
            100                 105                 110         


Gln Lys Asp Arg Tyr Thr Lys Asp Ile Tyr Thr Ile Lys Pro Asn Ala 
        115                 120                 125             


His Ile Cys Lys Thr Cys Tyr Ser Gly Val Ala Gly Asn Met Phe Ile 
    130                 135                 140                 


Arg Lys Gln Met Tyr Pro Asn Asp Lys Glu Gly Trp Lys Val Ser Arg 
145                 150                 155                 160 


Ser Tyr Asn Ile Lys Val Asn Ala Pro Gly Leu Thr Gly Thr Glu Tyr 
                165                 170                 175     


Ala Met Ala Ile Arg Lys Ala Ile Ser Ile Leu Arg Ser Phe Glu Lys 
            180                 185                 190         


Arg Arg Arg Asn Ala Glu Arg Arg Ile Ile Glu Tyr Glu Lys Ser Lys 
        195                 200                 205             


Lys Glu Tyr Leu Glu Leu Ile Asp Asp Val Glu Lys Gly Lys Thr Asn 
    210                 215                 220                 


Lys Ile Val Val Leu Glu Lys Glu Gly His Gln Arg Val Lys Arg Tyr 
225                 230                 235                 240 


Lys His Lys Asn Trp Pro Glu Lys Trp Gln Gly Ile Ser Leu Asn Lys 
                245                 250                 255     


Ala Lys Ser Lys Val Lys Asp Ile Glu Lys Arg Ile Lys Lys Leu Lys 
            260                 265                 270         


Glu Trp Lys His Pro Thr Leu Asn Arg Pro Tyr Val Glu Leu His Lys 
        275                 280                 285             


Asn Asn Val Arg Ile Val Gly Tyr Glu Thr Val Glu Leu Lys Leu Gly 
    290                 295                 300                 


Asn Lys Met Tyr Thr Ile His Phe Ala Ser Ile Ser Asn Leu Arg Lys 
305                 310                 315                 320 


Pro Phe Arg Lys Gln Lys Lys Lys Ser Ile Glu Tyr Leu Lys His Leu 
                325                 330                 335     


Leu Thr Leu Ala Leu Lys Arg Asn Leu Glu Thr Tyr Pro Ser Ile Ile 
            340                 345                 350         


Lys Arg Gly Lys Asn Phe Phe Leu Gln Tyr Pro Val Arg Val Thr Val 
        355                 360                 365             


Lys Val Pro Lys Leu Thr Lys Asn Phe Lys Ala Phe Gly Ile Asp Arg 
    370                 375                 380                 


Gly Val Asn Arg Leu Ala Val Gly Cys Ile Ile Ser Lys Asp Gly Lys 
385                 390                 395                 400 


Leu Thr Asn Lys Asn Ile Phe Phe Phe His Gly Lys Glu Ala Trp Ala 
                405                 410                 415     


Lys Glu Asn Arg Tyr Lys Lys Ile Arg Asp Arg Leu Tyr Ala Met Ala 
            420                 425                 430         


Lys Lys Leu Arg Gly Asp Lys Thr Lys Lys Ile Arg Leu Tyr His Glu 
        435                 440                 445             


Ile Arg Lys Lys Phe Arg His Lys Val Lys Tyr Phe Arg Arg Asn Tyr 
    450                 455                 460                 


Leu His Asn Ile Ser Lys Gln Ile Val Glu Ile Ala Lys Glu Asn Thr 
465                 470                 475                 480 


Pro Thr Val Ile Val Leu Glu Asp Leu Arg Tyr Leu Arg Glu Arg Thr 
                485                 490                 495     


Tyr Arg Gly Lys Gly Arg Ser Lys Lys Ala Lys Lys Thr Asn Tyr Lys 
            500                 505                 510         


Leu Asn Thr Phe Thr Tyr Arg Met Leu Ile Asp Met Ile Lys Tyr Lys 
        515                 520                 525             


Ala Glu Glu Ala Gly Val Pro Val Met Ile Ile Asp Pro Arg Asn Thr 
    530                 535                 540                 


Ser Arg Lys Cys Ser Lys Cys Gly Tyr Val Asp Glu Asn Asn Arg Lys 
545                 550                 555                 560 


Gln Ala Ser Phe Lys Cys Leu Lys Cys Gly Tyr Ser Leu Asn Ala Asp 
                565                 570                 575     


Leu Asn Ala Ala Val Asn Ile Ala Lys Ala Phe Tyr Glu Cys Pro Thr 
            580                 585                 590         


Phe Arg Trp Glu Glu Lys Leu His Ala Tyr Val Cys Ser Glu Pro Asp 
        595                 600                 605             


Lys 
    


<210> 49
<211> 599
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile 
1               5                   10                  15      


Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe 
            20                  25                  30          


Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser 
        35                  40                  45              


Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp 
    50                  55                  60                  


Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys 
65                  70                  75                  80  


Thr Phe Lys Phe Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys 
                85                  90                  95      


Asp Ile Tyr Thr Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr 
            100                 105                 110         


Ser Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn 
        115                 120                 125             


Asp Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn 
    130                 135                 140                 


Ala Pro Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala 
145                 150                 155                 160 


Ile Ser Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg 
                165                 170                 175     


Arg Ile Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile 
            180                 185                 190         


Asp Asp Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys 
        195                 200                 205             


Glu Gly His Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu 
    210                 215                 220                 


Lys Trp Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp 
225                 230                 235                 240 


Ile Glu Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu 
                245                 250                 255     


Asn Arg Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly 
            260                 265                 270         


Tyr Glu Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His 
        275                 280                 285             


Phe Ala Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys 
    290                 295                 300                 


Lys Ser Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg 
305                 310                 315                 320 


Asn Leu Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe 
                325                 330                 335     


Leu Gln Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys 
            340                 345                 350         


Asn Phe Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val 
        355                 360                 365             


Gly Cys Ile Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe 
    370                 375                 380                 


Phe Phe His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys 
385                 390                 395                 400 


Ile Arg Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys 
                405                 410                 415     


Thr Lys Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His 
            420                 425                 430         


Lys Val Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln 
        435                 440                 445             


Ile Val Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu 
    450                 455                 460                 


Asp Leu Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser 
465                 470                 475                 480 


Lys Lys Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg 
                485                 490                 495     


Met Leu Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro 
            500                 505                 510         


Val Met Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys 
        515                 520                 525             


Gly Tyr Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu 
    530                 535                 540                 


Lys Cys Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile 
545                 550                 555                 560 


Ala Lys Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu 
                565                 570                 575     


His Ala Tyr Val Cys Ser Glu Pro Asp Lys Gly Gly Ser Glu Gly Ala 
            580                 585                 590         


Pro Lys Lys Lys Arg Lys Val 
        595                 


<210> 50
<211> 596
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile 
1               5                   10                  15      


Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe 
            20                  25                  30          


Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser 
        35                  40                  45              


Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp 
    50                  55                  60                  


Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys 
65                  70                  75                  80  


Thr Phe Lys Phe Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys 
                85                  90                  95      


Asp Ile Tyr Thr Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr 
            100                 105                 110         


Ser Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn 
        115                 120                 125             


Asp Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn 
    130                 135                 140                 


Ala Pro Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala 
145                 150                 155                 160 


Ile Ser Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg 
                165                 170                 175     


Arg Ile Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile 
            180                 185                 190         


Asp Asp Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys 
        195                 200                 205             


Glu Gly His Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu 
    210                 215                 220                 


Lys Trp Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp 
225                 230                 235                 240 


Ile Glu Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu 
                245                 250                 255     


Asn Arg Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly 
            260                 265                 270         


Tyr Glu Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His 
        275                 280                 285             


Phe Ala Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys 
    290                 295                 300                 


Lys Ser Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg 
305                 310                 315                 320 


Asn Leu Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe 
                325                 330                 335     


Leu Gln Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys 
            340                 345                 350         


Asn Phe Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val 
        355                 360                 365             


Gly Cys Ile Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe 
    370                 375                 380                 


Phe Phe His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys 
385                 390                 395                 400 


Ile Arg Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys 
                405                 410                 415     


Thr Lys Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His 
            420                 425                 430         


Lys Val Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln 
        435                 440                 445             


Ile Val Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu 
    450                 455                 460                 


Asp Leu Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser 
465                 470                 475                 480 


Lys Lys Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg 
                485                 490                 495     


Met Leu Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro 
            500                 505                 510         


Val Met Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys 
        515                 520                 525             


Gly Tyr Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu 
    530                 535                 540                 


Lys Cys Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile 
545                 550                 555                 560 


Ala Lys Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu 
                565                 570                 575     


His Ala Tyr Val Cys Ser Glu Pro Asp Lys Gly Gly Ser Pro Lys Lys 
            580                 585                 590         


Lys Arg Lys Val 
        595     


<210> 51
<211> 598
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile 
1               5                   10                  15      


Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe 
            20                  25                  30          


Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser 
        35                  40                  45              


Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp 
    50                  55                  60                  


Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys 
65                  70                  75                  80  


Thr Phe Lys Phe Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys 
                85                  90                  95      


Asp Ile Tyr Thr Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr 
            100                 105                 110         


Ser Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn 
        115                 120                 125             


Asp Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn 
    130                 135                 140                 


Ala Pro Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala 
145                 150                 155                 160 


Ile Ser Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg 
                165                 170                 175     


Arg Ile Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile 
            180                 185                 190         


Asp Asp Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys 
        195                 200                 205             


Glu Gly His Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu 
    210                 215                 220                 


Lys Trp Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp 
225                 230                 235                 240 


Ile Glu Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu 
                245                 250                 255     


Asn Arg Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly 
            260                 265                 270         


Tyr Glu Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His 
        275                 280                 285             


Phe Ala Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys 
    290                 295                 300                 


Lys Ser Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg 
305                 310                 315                 320 


Asn Leu Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe 
                325                 330                 335     


Leu Gln Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys 
            340                 345                 350         


Asn Phe Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val 
        355                 360                 365             


Gly Cys Ile Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe 
    370                 375                 380                 


Phe Phe His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys 
385                 390                 395                 400 


Ile Arg Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys 
                405                 410                 415     


Thr Lys Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His 
            420                 425                 430         


Lys Val Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln 
        435                 440                 445             


Ile Val Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu 
    450                 455                 460                 


Asp Leu Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser 
465                 470                 475                 480 


Lys Lys Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg 
                485                 490                 495     


Met Leu Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro 
            500                 505                 510         


Val Met Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys 
        515                 520                 525             


Gly Tyr Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu 
    530                 535                 540                 


Lys Cys Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile 
545                 550                 555                 560 


Ala Lys Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu 
                565                 570                 575     


His Ala Tyr Val Cys Ser Glu Pro Asp Lys Gly Gly Ser Pro Ala Ala 
            580                 585                 590         


Lys Arg Val Lys Leu Asp 
        595             


<210> 52
<211> 598
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile 
1               5                   10                  15      


Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe 
            20                  25                  30          


Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser 
        35                  40                  45              


Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp 
    50                  55                  60                  


Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys 
65                  70                  75                  80  


Thr Phe Lys Phe Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys 
                85                  90                  95      


Asp Ile Tyr Thr Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr 
            100                 105                 110         


Ser Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn 
        115                 120                 125             


Asp Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn 
    130                 135                 140                 


Ala Pro Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala 
145                 150                 155                 160 


Ile Ser Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg 
                165                 170                 175     


Arg Ile Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile 
            180                 185                 190         


Asp Asp Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys 
        195                 200                 205             


Glu Gly His Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu 
    210                 215                 220                 


Lys Trp Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp 
225                 230                 235                 240 


Ile Glu Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu 
                245                 250                 255     


Asn Arg Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly 
            260                 265                 270         


Tyr Glu Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His 
        275                 280                 285             


Phe Ala Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys 
    290                 295                 300                 


Lys Ser Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg 
305                 310                 315                 320 


Asn Leu Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe 
                325                 330                 335     


Leu Gln Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys 
            340                 345                 350         


Asn Phe Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val 
        355                 360                 365             


Gly Cys Ile Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe 
    370                 375                 380                 


Phe Phe His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys 
385                 390                 395                 400 


Ile Arg Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys 
                405                 410                 415     


Thr Lys Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His 
            420                 425                 430         


Lys Val Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln 
        435                 440                 445             


Ile Val Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu 
    450                 455                 460                 


Asp Leu Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser 
465                 470                 475                 480 


Lys Lys Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg 
                485                 490                 495     


Met Leu Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro 
            500                 505                 510         


Val Met Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys 
        515                 520                 525             


Gly Tyr Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu 
    530                 535                 540                 


Lys Cys Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile 
545                 550                 555                 560 


Ala Lys Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu 
                565                 570                 575     


His Ala Tyr Val Cys Ser Glu Pro Asp Lys Gly Gly Ser Lys Leu Lys 
            580                 585                 590         


Ile Lys Arg Pro Val Lys 
        595             


<210> 53
<211> 609
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile 
1               5                   10                  15      


Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe 
            20                  25                  30          


Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser 
        35                  40                  45              


Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp 
    50                  55                  60                  


Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys 
65                  70                  75                  80  


Thr Phe Lys Phe Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys 
                85                  90                  95      


Asp Ile Tyr Thr Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr 
            100                 105                 110         


Ser Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn 
        115                 120                 125             


Asp Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn 
    130                 135                 140                 


Ala Pro Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala 
145                 150                 155                 160 


Ile Ser Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg 
                165                 170                 175     


Arg Ile Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile 
            180                 185                 190         


Asp Asp Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys 
        195                 200                 205             


Glu Gly His Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu 
    210                 215                 220                 


Lys Trp Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp 
225                 230                 235                 240 


Ile Glu Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu 
                245                 250                 255     


Asn Arg Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly 
            260                 265                 270         


Tyr Glu Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His 
        275                 280                 285             


Phe Ala Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys 
    290                 295                 300                 


Lys Ser Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg 
305                 310                 315                 320 


Asn Leu Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe 
                325                 330                 335     


Leu Gln Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys 
            340                 345                 350         


Asn Phe Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val 
        355                 360                 365             


Gly Cys Ile Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe 
    370                 375                 380                 


Phe Phe His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys 
385                 390                 395                 400 


Ile Arg Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys 
                405                 410                 415     


Thr Lys Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His 
            420                 425                 430         


Lys Val Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln 
        435                 440                 445             


Ile Val Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu 
    450                 455                 460                 


Asp Leu Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser 
465                 470                 475                 480 


Lys Lys Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg 
                485                 490                 495     


Met Leu Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro 
            500                 505                 510         


Val Met Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys 
        515                 520                 525             


Gly Tyr Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu 
    530                 535                 540                 


Lys Cys Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile 
545                 550                 555                 560 


Ala Lys Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu 
                565                 570                 575     


His Ala Tyr Val Cys Ser Glu Pro Asp Lys Gly Gly Ser Ala Val Lys 
            580                 585                 590         


Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys Leu 
        595                 600                 605             


Asp 
    


<210> 54
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Glu Gly Ala Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Met Pro Ser 
1               5                   10                  15      


Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile Pro Ser Asp 
            20                  25                  30          


Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe Gln Arg Ala 
        35                  40                  45              


Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser Ser Phe Arg 
    50                  55                  60                  


Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp Cys Cys Gly 
65                  70                  75                  80  


Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys Thr Phe Lys 
                85                  90                  95      


Phe Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys Asp Ile Tyr 
            100                 105                 110         


Thr Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr Ser Gly Val 
        115                 120                 125             


Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn Asp Lys Glu 
    130                 135                 140                 


Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn Ala Pro Gly 
145                 150                 155                 160 


Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile Ser Ile 
                165                 170                 175     


Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg Ile Ile 
            180                 185                 190         


Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp Asp Val 
        195                 200                 205             


Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu Gly His 
    210                 215                 220                 


Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu Lys Trp Gln 
225                 230                 235                 240 


Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu Lys 
                245                 250                 255     


Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg Pro 
            260                 265                 270         


Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr Glu Thr 
        275                 280                 285             


Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala Ser 
    290                 295                 300                 


Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser Ile 
305                 310                 315                 320 


Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu Glu 
                325                 330                 335     


Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln Tyr 
            340                 345                 350         


Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe Lys 
        355                 360                 365             


Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys Ile 
    370                 375                 380                 


Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe His 
385                 390                 395                 400 


Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg Asp 
                405                 410                 415     


Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys Lys 
            420                 425                 430         


Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val Lys 
        435                 440                 445             


Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val Glu 
    450                 455                 460                 


Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu Arg 
465                 470                 475                 480 


Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys Ala 
                485                 490                 495     


Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu Ile 
            500                 505                 510         


Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met Ile 
        515                 520                 525             


Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr Val 
    530                 535                 540                 


Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys Gly 
545                 550                 555                 560 


Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys Ala 
                565                 570                 575     


Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala Tyr 
            580                 585                 590         


Val Cys Ser Glu Pro Asp Lys Gly Gly Ser Glu Gly Ala Pro Lys Lys 
        595                 600                 605             


Lys Arg Lys Val 
    610         


<210> 55
<211> 605
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Met Pro Ser Glu Thr Tyr 
1               5                   10                  15      


Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile Pro Ser Asp Glu Glu Lys 
            20                  25                  30          


Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe Gln Arg Ala Val Asn Phe 
        35                  40                  45              


Ala Ile Asp Arg Ile Val Asp Ile Arg Ser Ser Phe Arg Tyr Leu Asn 
    50                  55                  60                  


Lys Asn Glu Gln Phe Pro Ala Val Cys Asp Cys Cys Gly Lys Lys Glu 
65                  70                  75                  80  


Lys Ile Met Tyr Val Asn Ile Ser Asn Lys Thr Phe Lys Phe Lys Pro 
                85                  90                  95      


Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys Asp Ile Tyr Thr Ile Lys 
            100                 105                 110         


Pro Asn Ala His Ile Cys Lys Thr Cys Tyr Ser Gly Val Ala Gly Asn 
        115                 120                 125             


Met Phe Ile Arg Lys Gln Met Tyr Pro Asn Asp Lys Glu Gly Trp Lys 
    130                 135                 140                 


Val Ser Arg Ser Tyr Asn Ile Lys Val Asn Ala Pro Gly Leu Thr Gly 
145                 150                 155                 160 


Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile Ser Ile Leu Arg Ser 
                165                 170                 175     


Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg Ile Ile Glu Tyr Glu 
            180                 185                 190         


Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp Asp Val Glu Lys Gly 
        195                 200                 205             


Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu Gly His Gln Arg Val 
    210                 215                 220                 


Lys Arg Tyr Lys His Lys Asn Trp Pro Glu Lys Trp Gln Gly Ile Ser 
225                 230                 235                 240 


Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu Lys Arg Ile Lys 
                245                 250                 255     


Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg Pro Tyr Val Glu 
            260                 265                 270         


Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr Glu Thr Val Glu Leu 
        275                 280                 285             


Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala Ser Ile Ser Asn 
    290                 295                 300                 


Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser Ile Glu Tyr Leu 
305                 310                 315                 320 


Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu Glu Thr Tyr Pro 
                325                 330                 335     


Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln Tyr Pro Val Arg 
            340                 345                 350         


Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe Lys Ala Phe Gly 
        355                 360                 365             


Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys Ile Ile Ser Lys 
    370                 375                 380                 


Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe His Gly Lys Glu 
385                 390                 395                 400 


Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg Asp Arg Leu Tyr 
                405                 410                 415     


Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys Lys Ile Arg Leu 
            420                 425                 430         


Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val Lys Tyr Phe Arg 
        435                 440                 445             


Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val Glu Ile Ala Lys 
    450                 455                 460                 


Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu Arg Tyr Leu Arg 
465                 470                 475                 480 


Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys Ala Lys Lys Thr 
                485                 490                 495     


Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu Ile Asp Met Ile 
            500                 505                 510         


Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met Ile Ile Asp Pro 
        515                 520                 525             


Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr Val Asp Glu Asn 
    530                 535                 540                 


Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys Gly Tyr Ser Leu 
545                 550                 555                 560 


Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys Ala Phe Tyr Glu 
                565                 570                 575     


Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala Tyr Val Cys Ser 
            580                 585                 590         


Glu Pro Asp Lys Gly Gly Ser Pro Lys Lys Lys Arg Lys 
        595                 600                 605 


<210> 56
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Met Pro Ser Glu 
1               5                   10                  15      


Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile Pro Ser Asp Glu 
            20                  25                  30          


Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe Gln Arg Ala Val 
        35                  40                  45              


Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser Ser Phe Arg Tyr 
    50                  55                  60                  


Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp Cys Cys Gly Lys 
65                  70                  75                  80  


Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys Thr Phe Lys Phe 
                85                  90                  95      


Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys Asp Ile Tyr Thr 
            100                 105                 110         


Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr Ser Gly Val Ala 
        115                 120                 125             


Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn Asp Lys Glu Gly 
    130                 135                 140                 


Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn Ala Pro Gly Leu 
145                 150                 155                 160 


Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile Ser Ile Leu 
                165                 170                 175     


Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg Ile Ile Glu 
            180                 185                 190         


Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp Asp Val Glu 
        195                 200                 205             


Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu Gly His Gln 
    210                 215                 220                 


Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu Lys Trp Gln Gly 
225                 230                 235                 240 


Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu Lys Arg 
                245                 250                 255     


Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg Pro Tyr 
            260                 265                 270         


Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr Glu Thr Val 
        275                 280                 285             


Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala Ser Ile 
    290                 295                 300                 


Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser Ile Glu 
305                 310                 315                 320 


Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu Glu Thr 
                325                 330                 335     


Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln Tyr Pro 
            340                 345                 350         


Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe Lys Ala 
        355                 360                 365             


Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys Ile Ile 
    370                 375                 380                 


Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe His Gly 
385                 390                 395                 400 


Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg Asp Arg 
                405                 410                 415     


Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys Lys Ile 
            420                 425                 430         


Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val Lys Tyr 
        435                 440                 445             


Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val Glu Ile 
    450                 455                 460                 


Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu Arg Tyr 
465                 470                 475                 480 


Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys Ala Lys 
                485                 490                 495     


Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu Ile Asp 
            500                 505                 510         


Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met Ile Ile 
        515                 520                 525             


Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr Val Asp 
    530                 535                 540                 


Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys Gly Tyr 
545                 550                 555                 560 


Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys Ala Phe 
                565                 570                 575     


Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala Tyr Val 
            580                 585                 590         


Cys Ser Glu Pro Asp Lys Gly Gly Ser Pro Ala Ala Lys Arg Val Lys 
        595                 600                 605             


Leu Asp 
    610 


<210> 57
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Lys Leu Lys Ile Lys Arg Pro Val Lys Gly Gly Ser Met Pro Ser Glu 
1               5                   10                  15      


Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile Pro Ser Asp Glu 
            20                  25                  30          


Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe Gln Arg Ala Val 
        35                  40                  45              


Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser Ser Phe Arg Tyr 
    50                  55                  60                  


Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp Cys Cys Gly Lys 
65                  70                  75                  80  


Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys Thr Phe Lys Phe 
                85                  90                  95      


Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys Asp Ile Tyr Thr 
            100                 105                 110         


Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr Ser Gly Val Ala 
        115                 120                 125             


Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn Asp Lys Glu Gly 
    130                 135                 140                 


Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn Ala Pro Gly Leu 
145                 150                 155                 160 


Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile Ser Ile Leu 
                165                 170                 175     


Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg Ile Ile Glu 
            180                 185                 190         


Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp Asp Val Glu 
        195                 200                 205             


Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu Gly His Gln 
    210                 215                 220                 


Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu Lys Trp Gln Gly 
225                 230                 235                 240 


Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu Lys Arg 
                245                 250                 255     


Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg Pro Tyr 
            260                 265                 270         


Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr Glu Thr Val 
        275                 280                 285             


Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala Ser Ile 
    290                 295                 300                 


Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser Ile Glu 
305                 310                 315                 320 


Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu Glu Thr 
                325                 330                 335     


Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln Tyr Pro 
            340                 345                 350         


Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe Lys Ala 
        355                 360                 365             


Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys Ile Ile 
    370                 375                 380                 


Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe His Gly 
385                 390                 395                 400 


Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg Asp Arg 
                405                 410                 415     


Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys Lys Ile 
            420                 425                 430         


Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val Lys Tyr 
        435                 440                 445             


Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val Glu Ile 
    450                 455                 460                 


Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu Arg Tyr 
465                 470                 475                 480 


Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys Ala Lys 
                485                 490                 495     


Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu Ile Asp 
            500                 505                 510         


Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met Ile Ile 
        515                 520                 525             


Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr Val Asp 
    530                 535                 540                 


Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys Gly Tyr 
545                 550                 555                 560 


Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys Ala Phe 
                565                 570                 575     


Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala Tyr Val 
            580                 585                 590         


Cys Ser Glu Pro Asp Lys Gly Gly Ser Lys Leu Lys Ile Lys Arg Pro 
        595                 600                 605             


Val Lys 
    610 


<210> 58
<211> 632
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 58
Ala Val Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys 
1               5                   10                  15      


Lys Lys Leu Asp Gly Gly Ser Met Pro Ser Glu Thr Tyr Ile Thr Lys 
            20                  25                  30          


Thr Leu Ser Leu Lys Leu Ile Pro Ser Asp Glu Glu Lys Gln Ala Leu 
        35                  40                  45              


Glu Asn Tyr Phe Ile Thr Phe Gln Arg Ala Val Asn Phe Ala Ile Asp 
    50                  55                  60                  


Arg Ile Val Asp Ile Arg Ser Ser Phe Arg Tyr Leu Asn Lys Asn Glu 
65                  70                  75                  80  


Gln Phe Pro Ala Val Cys Asp Cys Cys Gly Lys Lys Glu Lys Ile Met 
                85                  90                  95      


Tyr Val Asn Ile Ser Asn Lys Thr Phe Lys Phe Lys Pro Ser Arg Asn 
            100                 105                 110         


Gln Lys Asp Arg Tyr Thr Lys Asp Ile Tyr Thr Ile Lys Pro Asn Ala 
        115                 120                 125             


His Ile Cys Lys Thr Cys Tyr Ser Gly Val Ala Gly Asn Met Phe Ile 
    130                 135                 140                 


Arg Lys Gln Met Tyr Pro Asn Asp Lys Glu Gly Trp Lys Val Ser Arg 
145                 150                 155                 160 


Ser Tyr Asn Ile Lys Val Asn Ala Pro Gly Leu Thr Gly Thr Glu Tyr 
                165                 170                 175     


Ala Met Ala Ile Arg Lys Ala Ile Ser Ile Leu Arg Ser Phe Glu Lys 
            180                 185                 190         


Arg Arg Arg Asn Ala Glu Arg Arg Ile Ile Glu Tyr Glu Lys Ser Lys 
        195                 200                 205             


Lys Glu Tyr Leu Glu Leu Ile Asp Asp Val Glu Lys Gly Lys Thr Asn 
    210                 215                 220                 


Lys Ile Val Val Leu Glu Lys Glu Gly His Gln Arg Val Lys Arg Tyr 
225                 230                 235                 240 


Lys His Lys Asn Trp Pro Glu Lys Trp Gln Gly Ile Ser Leu Asn Lys 
                245                 250                 255     


Ala Lys Ser Lys Val Lys Asp Ile Glu Lys Arg Ile Lys Lys Leu Lys 
            260                 265                 270         


Glu Trp Lys His Pro Thr Leu Asn Arg Pro Tyr Val Glu Leu His Lys 
        275                 280                 285             


Asn Asn Val Arg Ile Val Gly Tyr Glu Thr Val Glu Leu Lys Leu Gly 
    290                 295                 300                 


Asn Lys Met Tyr Thr Ile His Phe Ala Ser Ile Ser Asn Leu Arg Lys 
305                 310                 315                 320 


Pro Phe Arg Lys Gln Lys Lys Lys Ser Ile Glu Tyr Leu Lys His Leu 
                325                 330                 335     


Leu Thr Leu Ala Leu Lys Arg Asn Leu Glu Thr Tyr Pro Ser Ile Ile 
            340                 345                 350         


Lys Arg Gly Lys Asn Phe Phe Leu Gln Tyr Pro Val Arg Val Thr Val 
        355                 360                 365             


Lys Val Pro Lys Leu Thr Lys Asn Phe Lys Ala Phe Gly Ile Asp Arg 
    370                 375                 380                 


Gly Val Asn Arg Leu Ala Val Gly Cys Ile Ile Ser Lys Asp Gly Lys 
385                 390                 395                 400 


Leu Thr Asn Lys Asn Ile Phe Phe Phe His Gly Lys Glu Ala Trp Ala 
                405                 410                 415     


Lys Glu Asn Arg Tyr Lys Lys Ile Arg Asp Arg Leu Tyr Ala Met Ala 
            420                 425                 430         


Lys Lys Leu Arg Gly Asp Lys Thr Lys Lys Ile Arg Leu Tyr His Glu 
        435                 440                 445             


Ile Arg Lys Lys Phe Arg His Lys Val Lys Tyr Phe Arg Arg Asn Tyr 
    450                 455                 460                 


Leu His Asn Ile Ser Lys Gln Ile Val Glu Ile Ala Lys Glu Asn Thr 
465                 470                 475                 480 


Pro Thr Val Ile Val Leu Glu Asp Leu Arg Tyr Leu Arg Glu Arg Thr 
                485                 490                 495     


Tyr Arg Gly Lys Gly Arg Ser Lys Lys Ala Lys Lys Thr Asn Tyr Lys 
            500                 505                 510         


Leu Asn Thr Phe Thr Tyr Arg Met Leu Ile Asp Met Ile Lys Tyr Lys 
        515                 520                 525             


Ala Glu Glu Ala Gly Val Pro Val Met Ile Ile Asp Pro Arg Asn Thr 
    530                 535                 540                 


Ser Arg Lys Cys Ser Lys Cys Gly Tyr Val Asp Glu Asn Asn Arg Lys 
545                 550                 555                 560 


Gln Ala Ser Phe Lys Cys Leu Lys Cys Gly Tyr Ser Leu Asn Ala Asp 
                565                 570                 575     


Leu Asn Ala Ala Val Asn Ile Ala Lys Ala Phe Tyr Glu Cys Pro Thr 
            580                 585                 590         


Phe Arg Trp Glu Glu Lys Leu His Ala Tyr Val Cys Ser Glu Pro Asp 
        595                 600                 605             


Lys Gly Gly Ser Ala Val Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly 
    610                 615                 620                 


Gln Ala Lys Lys Lys Lys Leu Asp 
625                 630         


<210> 59
<211> 827
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 59
Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile 
1               5                   10                  15      


Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe 
            20                  25                  30          


Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser 
        35                  40                  45              


Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp 
    50                  55                  60                  


Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys 
65                  70                  75                  80  


Thr Phe Lys Phe Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys 
                85                  90                  95      


Asp Ile Tyr Thr Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr 
            100                 105                 110         


Ser Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn 
        115                 120                 125             


Asp Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn 
    130                 135                 140                 


Ala Pro Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala 
145                 150                 155                 160 


Ile Ser Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg 
                165                 170                 175     


Arg Ile Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile 
            180                 185                 190         


Asp Asp Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys 
        195                 200                 205             


Glu Gly His Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu 
    210                 215                 220                 


Lys Trp Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp 
225                 230                 235                 240 


Ile Glu Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu 
                245                 250                 255     


Asn Arg Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly 
            260                 265                 270         


Tyr Glu Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His 
        275                 280                 285             


Phe Ala Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys 
    290                 295                 300                 


Lys Ser Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg 
305                 310                 315                 320 


Asn Leu Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe 
                325                 330                 335     


Leu Gln Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys 
            340                 345                 350         


Asn Phe Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val 
        355                 360                 365             


Gly Cys Ile Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe 
    370                 375                 380                 


Phe Phe His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys 
385                 390                 395                 400 


Ile Arg Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys 
                405                 410                 415     


Thr Lys Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His 
            420                 425                 430         


Lys Val Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln 
        435                 440                 445             


Ile Val Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu 
    450                 455                 460                 


Asp Leu Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser 
465                 470                 475                 480 


Lys Lys Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg 
                485                 490                 495     


Met Leu Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro 
            500                 505                 510         


Val Met Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys 
        515                 520                 525             


Gly Tyr Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu 
    530                 535                 540                 


Lys Cys Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile 
545                 550                 555                 560 


Ala Lys Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu 
                565                 570                 575     


His Ala Tyr Val Cys Ser Glu Pro Asp Lys Gly Gly Ser Val Ser Lys 
            580                 585                 590         


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
        595                 600                 605             


Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly 
    610                 615                 620                 


Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly 
625                 630                 635                 640 


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly 
                645                 650                 655     


Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
            660                 665                 670         


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Ser 
        675                 680                 685             


Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
    690                 695                 700                 


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
705                 710                 715                 720 


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe Asn Ser 
                725                 730                 735     


His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala 
            740                 745                 750         


Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala 
        755                 760                 765             


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
    770                 775                 780                 


Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro 
785                 790                 795                 800 


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
                805                 810                 815     


Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
            820                 825         


<210> 60
<211> 586
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 60
Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile 
1               5                   10                  15      


Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe 
            20                  25                  30          


Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser 
        35                  40                  45              


Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp 
    50                  55                  60                  


Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys 
65                  70                  75                  80  


Thr Phe Lys Phe Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys 
                85                  90                  95      


Asp Ile Tyr Thr Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr 
            100                 105                 110         


Ser Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn 
        115                 120                 125             


Asp Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn 
    130                 135                 140                 


Ala Pro Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala 
145                 150                 155                 160 


Ile Ser Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg 
                165                 170                 175     


Arg Ile Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile 
            180                 185                 190         


Asp Asp Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys 
        195                 200                 205             


Glu Gly His Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu 
    210                 215                 220                 


Lys Trp Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp 
225                 230                 235                 240 


Ile Glu Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu 
                245                 250                 255     


Asn Arg Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly 
            260                 265                 270         


Tyr Glu Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His 
        275                 280                 285             


Phe Ala Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys 
    290                 295                 300                 


Lys Ser Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg 
305                 310                 315                 320 


Asn Leu Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe 
                325                 330                 335     


Leu Gln Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys 
            340                 345                 350         


Asn Phe Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val 
        355                 360                 365             


Gly Cys Ile Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe 
    370                 375                 380                 


Phe Phe His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys 
385                 390                 395                 400 


Ile Arg Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys 
                405                 410                 415     


Thr Lys Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His 
            420                 425                 430         


Lys Val Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln 
        435                 440                 445             


Ile Val Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu 
    450                 455                 460                 


Asp Leu Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser 
465                 470                 475                 480 


Lys Lys Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg 
                485                 490                 495     


Met Leu Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro 
            500                 505                 510         


Val Met Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys 
        515                 520                 525             


Gly Tyr Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu 
    530                 535                 540                 


Lys Cys Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile 
545                 550                 555                 560 


Ala Lys Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu 
                565                 570                 575     


His Ala Tyr Val Cys Ser Glu Pro Asp Lys 
            580                 585     


<210> 61
<211> 128
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 61
gctttaataa gtggtgcctt ccaaagctat atgctgaggg aggatgggcg ctgttgcagc       60

gtctgcccac ctcagagtgg gtatccttac ctattgaaaa cccaaagtaa taggtcaagg      120

aatgcaac                                                               128


<210> 62
<211> 135
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 62
gattgtatta tgctccactt taataagtgg tgccttccaa agctatatgc tgagggagga       60

tgggcgctgt tgcagcgtct gcccacctca gagtgggtat ccttacctat tgaaaaatag      120

gtcaaggaat gcaac                                                       135


<210> 63
<211> 122
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 63
gctttaataa gtggtgcctt ccaaagctat atgctgaggg aggatgggcg ctgttgcagc       60

gtctgcccac ctcagagtgg gtatccttac ctattgaaaa gtaataggtc aaggaatgca      120

ac                                                                     122


<210> 64
<211> 119
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 64
gctttaataa gtggtgcctt ccaaagctat atgctgaggg aggatgggcg ctgttgcagc       60

gtctgcccac ctcagagtgg gtatccttac ctattgaaaa ataggtcaag gaatgcaac       119


<210> 65
<211> 120
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 65
gctttaataa gtggtgcctt ccaaagctat atgctgaggg aggatgggcg ctgttgcagc       60

gtctgcccac ctcagagtgg gtatccttac ctattgaaat aataggtcaa ggaatgcaac      120


<210> 66
<211> 116
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 66
ggtgccttcc aaagctatat gctgagggag gatgggcgct gttgcagcgt ctgcccacct       60

cagagtgggt atccttacct attgaaaacc caaagtaata ggtcaaggaa tgcaac          116


<210> 67
<211> 110
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 67
ggtgccttcc aaagctatat gctgagggag gatgggcgct gttgcagcgt ctgcccacct       60

cagagtgggt atccttacct attgaaaagt aataggtcaa ggaatgcaac                 110


<210> 68
<211> 107
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 68
ggtgccttcc aaagctatat gctgagggag gatgggcgct gttgcagcgt ctgcccacct       60

cagagtgggt atccttacct attgaaaaat aggtcaagga atgcaac                    107


<210> 69
<211> 108
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 69
ggtgccttcc aaagctatat gctgagggag gatgggcgct gttgcagcgt ctgcccacct       60

cagagtgggt atccttacct attgaaataa taggtcaagg aatgcaac                   108


<210> 70
<211> 144
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 70
gattgtatta tgctccactt taataagtgg tgccttccaa agctatatgc tgagggagga       60

tgggcgctgt tgcagcgtct gcccacctca gagtgggtat ccttacctat tgaaaaccca      120

aagtaatagg tcaaggaatg caac                                             144


<210> 71
<211> 137
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 71
gattgtatta tgctccactt taataagtgg tgccttccaa agctatatgc tgagggagga       60

tgggcgctgt tgcagcgtct gcccacctca gatgggtatc cttacctatt gaaaagtaat      120

aggtcaagga atgcaac                                                     137


<210> 72
<211> 136
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 72
gattgtatta tgctccactt taataagtgg tgccttccaa agctatatgc tgagggagga       60

tgggcgctgt tgcagcgtct gcccacctca gagtgggtat ccttacctat tgaaataata      120

ggtcaaggaa tgcaac                                                      136


<210> 73
<211> 113
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 73
gccttccaaa gctatatgct gagggaggat gggcgctgtt gcagcgtctg cccacctcag       60

agtgggtatc cttacctatt gaaaacccaa agtaataggt caaggaatgc aac             113


<210> 74
<211> 113
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 74
gccttccaaa gctatatgct gagggaggat gggcgctgtt gcagcgtctg cccacctcag       60

agtgggtatc cttacctatt gaaaacccaa agtaataggt caaggaatgc aac             113


<210> 75
<211> 105
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 75
gccttccaaa gctatatgct gagggaggat gggcgctgtt gcagcgtctt gcccacctca       60

gagtgggtat ccttacctat tgaaaaatag gtcaaggaat gcaac                      105


<210> 76
<211> 106
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 76
gtgccttcca aagctatatg ctgagggagg atgggcgctg ttgcagcgtc tgcccacctc       60

agagtgggta tccttaccta ttgaaaaata ggtcaaggaa tgcaac                     106


<210> 77
<211> 107
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 77
gtgccttcca aagctatatg ctgagggagg atgggcgctg ttgcagcgtc tgcccacctc       60

agagtgggta tccttaccta ttgaaataat aggtcaagga atgcaac                    107


<210> 78
<211> 133
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 78
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg aaaaacccaa agtaataggt      120

caaggaatgc aac                                                         133


<210> 79
<211> 104
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 79
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg aaaa                       104


<210> 80
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 80
gacccaaagt aataggtcaa ggaatgcaac tggttgccca ccctagtcat tg               52


<210> 81
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 81
gagtaatagg tcaaggaatg caactggttg cccaccctag tcattg                      46


<210> 82
<211> 43
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 82
gaataggtca aggaatgcaa ctggttgccc accctagtca ttg                         43


<210> 83
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 83
gtaataggtc aaggaatgca actggttgcc caccctagtc attg                        44


<210> 84
<211> 109
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 84
gattgtatta tgctccactt taataagtgg tgccttccaa agctatatgc tgagggagga       60

tgggcgctgt tgcagcgtct gcccacctca gagtgggtat ccttaccta                  109


<210> 85
<211> 93
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 85
gctttaataa gtggtgcctt ccaaagctat atgctgaggg aggatgggcg ctgttgcagc       60

gtctgcccac ctcagagtgg gtatccttac cta                                    93


<210> 86
<211> 81
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 86
ggtgccttcc aaagctatat gctgagggag gatgggcgct gttgcagcgt ctgcccacct       60

cagagtgggt atccttacct a                                                 81


<210> 87
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 87
gccttccaaa gctatatgct gagggaggat gggcgctgtt gcagcgtctg cccacctcag       60

agtgggtatc cttaccta                                                     78


<210> 88
<211> 109
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 88
gattgtatta tgctccactt taataagtgg tgccttccaa agctatatgc tgagggagga       60

tgggcgctgt tgcagcgtct gcccacctca gagtgggtat ccttaccta                  109


<210> 89
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 89
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttaccta                                97


<210> 90
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 90
gtgccttcca aagctatatg ctgagggagg atgggcgctg ttgcagcgtc tgcccacctc       60

agagtgggta tccttaccta                                                   80


<210> 91
<211> 132
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 91
gttatgctcc actttaataa gtggtgcctt ccaaagctat atgctgaggg aggatgggcg       60

ctgttgcagc gtctgcccac ctcagagtgg gtatccttac ctattgaaaa gtaataggtc      120

aaggaatgca ac                                                          132


<210> 92
<211> 131
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 92
gtatgctcca ctttaataag tggtgccttc caaagctata tgctgaggga ggatgggcgc       60

tgttgcagcg tctgcccacc tcagagtggg tatccttacc tattgaaaag taataggtca      120

aggaatgcaa c                                                           131


<210> 93
<211> 130
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 93
gatgctccac tttaataagt ggtgccttcc aaagctatat gctgagggag gatgggcgct       60

gttgcagcgt ctgcccacct cagagtgggt atccttacct attgaaaagt aataggtcaa      120

ggaatgcaac                                                             130


<210> 94
<211> 126
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 94
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg aaaagtaata ggtcaaggaa      120

tgcaac                                                                 126


<210> 95
<211> 127
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 95
gctccgcttt aataagcggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaac                                                                127


<210> 96
<211> 127
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 96
gctccacttt actaagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaac                                                                127


<210> 97
<211> 127
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 97
gcaccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaac                                                                127


<210> 98
<211> 127
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 98
gctccacttt aataagtgga gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaac                                                                127


<210> 99
<211> 127
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 99
gctccactgt aatcagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaac                                                                127


<210> 100
<211> 129
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 100
gtgctccact ttaataagtg gtgcattcca aagctatatg ctgagggagg atgggcgctg       60

ttgcagcgtc tgcccacctc agagtgggta tccttaccta ttgaaaagta ataggtcaag      120

gaatgcaac                                                              129


<210> 101
<211> 129
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 101
gctccacttg taatcaagtg gtgccttcca aagctatatg ctgagggagg atgggcgctg       60

ttgcagcgtc tgcccacctc agagtgggta tccttaccta ttgaaaagta ataggtcaag      120

gaatgcaac                                                              129


<210> 102
<211> 131
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 102
gctccacttg ctaatgcaag tggtgccttc caaagctata tgctgaggga ggatgggcgc       60

tgttgcagcg tctgcccacc tcagagtggg tatccttacc tattgaaaag taataggtca      120

aggaatgcaa c                                                           131


<210> 103
<211> 133
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 103
gctccacttg gctaatgcca agtggtgcct tccaaagcta tatgctgagg gaggatgggc       60

gctgttgcag cgtctgccca cctcagagtg ggtatcctta cctattgaaa agtaataggt      120

caaggaatgc aac                                                         133


<210> 104
<211> 135
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 104
gctccacttg gcataattgc caagtggtgc cttccaaagc tatatgctga gggaggatgg       60

gcgctgttgc agcgtctgcc cacctcagag tgggtatcct tacctattga aaagtaatag      120

gtcaaggaat gcaac                                                       135


<210> 105
<211> 142
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 105
gctccactta catgaggatc acccatgtaa gtggtgcctt ccaaagctat atgctgaggg       60

aggatgggcg ctgttgcagc gtctgcccac ctcagagtgg gtatccttac ctattgaaaa      120

gtaataggtc aaggaatgca ac                                               142


<210> 106
<211> 126
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 106
gctccacttt aataagtggt gccttccaaa gctaatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg aaaagtaata ggtcaaggaa      120

tgcaac                                                                 126


<210> 107
<211> 127
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 107
gctccacttt aataagtggt gccttccaaa gctaaatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaac                                                                127


<210> 108
<211> 129
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 108
gctccacttt aataagtggt gccttccaaa gcctatatgg ctgagggagg atgggcgctg       60

ttgcagcgtc tgcccacctc agagtgggta tccttaccta ttgaaaagta ataggtcaag      120

gaatgcaac                                                              129


<210> 109
<211> 131
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 109
gctccacttt aataagtggt gccttccaaa gctgtatatc agctgaggga ggatgggcgc       60

tgttgcagcg tctgcccacc tcagagtggg tatccttacc tattgaaaag taataggtca      120

aggaatgcaa c                                                           131


<210> 110
<211> 133
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 110
gctccacttt aataagtggt gccttccaaa gctgctatat gcagctgagg gaggatgggc       60

gctgttgcag cgtctgccca cctcagagtg ggtatcctta cctattgaaa agtaataggt      120

caaggaatgc aac                                                         133


<210> 111
<211> 135
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 111
gctccacttt aataagtggt gccttccaaa gctgcttata tagcagctga gggaggatgg       60

gcgctgttgc agcgtctgcc cacctcagag tgggtatcct tacctattga aaagtaatag      120

gtcaaggaat gcaac                                                       135


<210> 112
<211> 137
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 112
gctccacttt aataagtggt gccttccaaa gctgctgtat atcagcagct gagggaggat       60

gggcgctgtt gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat      120

aggtcaagga atgcaac                                                     137


<210> 113
<211> 141
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 113
gctccacttt aataagtggt gccttccaaa gcacatgagg atcacccatg tgctgaggga       60

ggatgggcgc tgttgcagcg tctgcccacc tcagagtggg tatccttacc tattgaaaag      120

taataggtca aggaatgcaa c                                                141


<210> 114
<211> 127
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 114
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

caagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

ttgcaac                                                                127


<210> 115
<211> 127
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 115
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cacgcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

gtgcaac                                                                127


<210> 116
<211> 127
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 116
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

caggcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

ctgcaac                                                                127


<210> 117
<211> 127
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 117
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

catgcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaac                                                                127


<210> 118
<211> 127
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 118
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttc       60

gatgcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atcgaac                                                                127


<210> 119
<211> 127
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 119
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

agtgcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

actcaac                                                                127


<210> 120
<211> 127
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 120
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cgtgcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

acgcaac                                                                127


<210> 121
<211> 127
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 121
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

tatgcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atacaac                                                                127


<210> 122
<211> 127
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 122
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgccg       60

catgcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcggc                                                                127


<210> 123
<211> 127
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 123
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgcgg       60

catgcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgccgc                                                                127


<210> 124
<211> 126
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 124
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cggcgtctgc ccacctcaga gtgggtatcc ttacctattg aaaagtaata ggtcaaggaa      120

cgcaac                                                                 126


<210> 125
<211> 126
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 125
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

tagcgtctgc ccacctcaga gtgggtatcc ttacctattg aaaagtaata ggtcaaggaa      120

tacaac                                                                 126


<210> 126
<211> 126
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 126
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgccg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg aaaagtaata ggtcaaggaa      120

tgcggc                                                                 126


<210> 127
<211> 126
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 127
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgcgg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg aaaagtaata ggtcaaggaa      120

tgccgc                                                                 126


<210> 128
<211> 128
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 128
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacgctag acgtgggtat ccttacctat tgaaaagtaa taggtcaagg      120

aatgcaac                                                               128


<210> 129
<211> 130
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 129
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccactgcta gacagtgggt atccttacct attgaaaagt aataggtcaa      120

ggaatgcaac                                                             130


<210> 130
<211> 132
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 130
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctgct agacaggtgg gtatccttac ctattgaaaa gtaataggtc      120

aaggaatgca ac                                                          132


<210> 131
<211> 129
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 131
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacgctca gacgtgggta tccttaccta ttgaaaagta ataggtcaag      120

gaatgcaac                                                              129


<210> 132
<211> 131
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 132
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccactgctc agacagtggg tatccttacc tattgaaaag taataggtca      120

aggaatgcaa c                                                           131


<210> 133
<211> 133
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 133
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctgct cagacaggtg ggtatcctta cctattgaaa agtaataggt      120

caaggaatgc aac                                                         133


<210> 134
<211> 135
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 134
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacgctgc tcagacagcg tgggtatcct tacctattga aaagtaatag      120

gtcaaggaat gcaac                                                       135


<210> 135
<211> 137
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 135
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccactgctg ctcagacagc agtgggtatc cttacctatt gaaaagtaat      120

aggtcaagga atgcaac                                                     137


<210> 136
<211> 140
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 136
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacacatg aggatcaccc atgtgtgggt atccttacct attgaaaagt      120

aataggtcaa ggaatgcaac                                                  140


<210> 137
<211> 125
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 137
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctatta aaagtaatag gtcaaggaat      120

gcaac                                                                  125


<210> 138
<211> 128
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 138
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg gaaaagctaa taggtcaagg      120

aatgcaac                                                               128


<210> 139
<211> 130
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 139
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg ctaaaagagt aataggtcaa      120

ggaatgcaac                                                             130


<210> 140
<211> 130
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 140
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg tgaaaagcat aataggtcaa      120

ggaatgcaac                                                             130


<210> 141
<211> 132
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 141
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg ctgaaaagca gtaataggtc      120

aaggaatgca ac                                                          132


<210> 142
<211> 134
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 142
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg gctgaaaagc agctaatagg      120

tcaaggaatg caac                                                        134


<210> 143
<211> 136
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 143
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg tgctgaaaag cagcataata      120

ggtcaaggaa tgcaac                                                      136


<210> 144
<211> 138
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 144
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctatta catgaggatc acccatgtaa      120

taggtcaagg aatgcaac                                                    138


<210> 145
<211> 154
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 145
gttatgctcc actttaataa gtggtgcctt ccaaagctat atgctgaggg aggatgggcg       60

ctgttgcagc gtctgcccac ctcagagtgg gtatccttac ctattgaaaa gtaataggtc      120

aaggaatgca actggttgcc caccctagtc attg                                  154


<210> 146
<211> 153
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 146
gtatgctcca ctttaataag tggtgccttc caaagctata tgctgaggga ggatgggcgc       60

tgttgcagcg tctgcccacc tcagagtggg tatccttacc tattgaaaag taataggtca      120

aggaatgcaa ctggttgccc accctagtca ttg                                   153


<210> 147
<211> 152
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 147
gatgctccac tttaataagt ggtgccttcc aaagctatat gctgagggag gatgggcgct       60

gttgcagcgt ctgcccacct cagagtgggt atccttacct attgaaaagt aataggtcaa      120

ggaatgcaac tggttgccca ccctagtcat tg                                    152


<210> 148
<211> 148
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 148
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg aaaagtaata ggtcaaggaa      120

tgcaactggt tgcccaccct agtcattg                                         148


<210> 149
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 149
gctccgcttt aataagcggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaactgg ttgcccaccc tagtcattg                                        149


<210> 150
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 150
gctccacttt actaagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaactgg ttgcccaccc tagtcattg                                        149


<210> 151
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 151
gcaccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaactgg ttgcccaccc tagtcattg                                        149


<210> 152
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 152
gctccacttt aataagtgga gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaactgg ttgcccaccc tagtcattg                                        149


<210> 153
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 153
gctccactgt aatcagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaactgg ttgcccaccc tagtcattg                                        149


<210> 154
<211> 151
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 154
gtgctccact ttaataagtg gtgcattcca aagctatatg ctgagggagg atgggcgctg       60

ttgcagcgtc tgcccacctc agagtgggta tccttaccta ttgaaaagta ataggtcaag      120

gaatgcaact ggttgcccac cctagtcatt g                                     151


<210> 155
<211> 151
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 155
gctccacttg taatcaagtg gtgccttcca aagctatatg ctgagggagg atgggcgctg       60

ttgcagcgtc tgcccacctc agagtgggta tccttaccta ttgaaaagta ataggtcaag      120

gaatgcaact ggttgcccac cctagtcatt g                                     151


<210> 156
<211> 153
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 156
gctccacttg ctaatgcaag tggtgccttc caaagctata tgctgaggga ggatgggcgc       60

tgttgcagcg tctgcccacc tcagagtggg tatccttacc tattgaaaag taataggtca      120

aggaatgcaa ctggttgccc accctagtca ttg                                   153


<210> 157
<211> 155
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 157
gctccacttg gctaatgcca agtggtgcct tccaaagcta tatgctgagg gaggatgggc       60

gctgttgcag cgtctgccca cctcagagtg ggtatcctta cctattgaaa agtaataggt      120

caaggaatgc aactggttgc ccaccctagt cattg                                 155


<210> 158
<211> 157
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 158
gctccacttg gcataattgc caagtggtgc cttccaaagc tatatgctga gggaggatgg       60

gcgctgttgc agcgtctgcc cacctcagag tgggtatcct tacctattga aaagtaatag      120

gtcaaggaat gcaactggtt gcccacccta gtcattg                               157


<210> 159
<211> 164
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 159
gctccactta catgaggatc acccatgtaa gtggtgcctt ccaaagctat atgctgaggg       60

aggatgggcg ctgttgcagc gtctgcccac ctcagagtgg gtatccttac ctattgaaaa      120

gtaataggtc aaggaatgca actggttgcc caccctagtc attg                       164


<210> 160
<211> 148
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 160
gctccacttt aataagtggt gccttccaaa gctaatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg aaaagtaata ggtcaaggaa      120

tgcaactggt tgcccaccct agtcattg                                         148


<210> 161
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 161
gctccacttt aataagtggt gccttccaaa gctaaatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaactgg ttgcccaccc tagtcattg                                        149


<210> 162
<211> 151
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 162
gctccacttt aataagtggt gccttccaaa gcctatatgg ctgagggagg atgggcgctg       60

ttgcagcgtc tgcccacctc agagtgggta tccttaccta ttgaaaagta ataggtcaag      120

gaatgcaact ggttgcccac cctagtcatt g                                     151


<210> 163
<211> 153
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 163
gctccacttt aataagtggt gccttccaaa gctgtatatc agctgaggga ggatgggcgc       60

tgttgcagcg tctgcccacc tcagagtggg tatccttacc tattgaaaag taataggtca      120

aggaatgcaa ctggttgccc accctagtca ttg                                   153


<210> 164
<211> 155
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 164
gctccacttt aataagtggt gccttccaaa gctgctatat gcagctgagg gaggatgggc       60

gctgttgcag cgtctgccca cctcagagtg ggtatcctta cctattgaaa agtaataggt      120

caaggaatgc aactggttgc ccaccctagt cattg                                 155


<210> 165
<211> 157
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 165
gctccacttt aataagtggt gccttccaaa gctgcttata tagcagctga gggaggatgg       60

gcgctgttgc agcgtctgcc cacctcagag tgggtatcct tacctattga aaagtaatag      120

gtcaaggaat gcaactggtt gcccacccta gtcattg                               157


<210> 166
<211> 159
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 166
gctccacttt aataagtggt gccttccaaa gctgctgtat atcagcagct gagggaggat       60

gggcgctgtt gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat      120

aggtcaagga atgcaactgg ttgcccaccc tagtcattg                             159


<210> 167
<211> 163
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 167
gctccacttt aataagtggt gccttccaaa gcacatgagg atcacccatg tgctgaggga       60

ggatgggcgc tgttgcagcg tctgcccacc tcagagtggg tatccttacc tattgaaaag      120

taataggtca aggaatgcaa ctggttgccc accctagtca ttg                        163


<210> 168
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 168
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

caagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

ttgcaactgg ttgcccaccc tagtcattg                                        149


<210> 169
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 169
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cacgcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

gtgcaactgg ttgcccaccc tagtcattg                                        149


<210> 170
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 170
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

caggcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

ctgcaactgg ttgcccaccc tagtcattg                                        149


<210> 171
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 171
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

catgcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaactgg ttgcccaccc tagtcattg                                        149


<210> 172
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 172
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttc       60

gatgcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atcgaactgg ttgcccaccc tagtcattg                                        149


<210> 173
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 173
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

agtgcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

actcaactgg ttgcccaccc tagtcattg                                        149


<210> 174
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 174
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cgtgcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

acgcaactgg ttgcccaccc tagtcattg                                        149


<210> 175
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 175
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

tatgcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atacaactgg ttgcccaccc tagtcattg                                        149


<210> 176
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 176
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgccg       60

catgcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcggctgg ttgcccaccc tagtcattg                                        149


<210> 177
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 177
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgcgg       60

catgcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgccgctgg ttgcccaccc tagtcattg                                        149


<210> 178
<211> 148
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 178
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cggcgtctgc ccacctcaga gtgggtatcc ttacctattg aaaagtaata ggtcaaggaa      120

cgcaactggt tgcccaccct agtcattg                                         148


<210> 179
<211> 148
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 179
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

tagcgtctgc ccacctcaga gtgggtatcc ttacctattg aaaagtaata ggtcaaggaa      120

tacaactggt tgcccaccct agtcattg                                         148


<210> 180
<211> 148
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 180
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgccg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg aaaagtaata ggtcaaggaa      120

tgcggctggt tgcccaccct agtcattg                                         148


<210> 181
<211> 148
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 181
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgcgg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg aaaagtaata ggtcaaggaa      120

tgccgctggt tgcccaccct agtcattg                                         148


<210> 182
<211> 150
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 182
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacgctag acgtgggtat ccttacctat tgaaaagtaa taggtcaagg      120

aatgcaactg gttgcccacc ctagtcattg                                       150


<210> 183
<211> 152
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 183
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccactgcta gacagtgggt atccttacct attgaaaagt aataggtcaa      120

ggaatgcaac tggttgccca ccctagtcat tg                                    152


<210> 184
<211> 154
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 184
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctgct agacaggtgg gtatccttac ctattgaaaa gtaataggtc      120

aaggaatgca actggttgcc caccctagtc attg                                  154


<210> 185
<211> 151
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 185
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacgctca gacgtgggta tccttaccta ttgaaaagta ataggtcaag      120

gaatgcaact ggttgcccac cctagtcatt g                                     151


<210> 186
<211> 153
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 186
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccactgctc agacagtggg tatccttacc tattgaaaag taataggtca      120

aggaatgcaa ctggttgccc accctagtca ttg                                   153


<210> 187
<211> 157
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 187
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacgctgc tcagacagcg tgggtatcct tacctattga aaagtaatag      120

gtcaaggaat gcaactggtt gcccacccta gtcattg                               157


<210> 188
<211> 159
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 188
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccactgctg ctcagacagc agtgggtatc cttacctatt gaaaagtaat      120

aggtcaagga atgcaactgg ttgcccaccc tagtcattg                             159


<210> 189
<211> 162
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 189
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacacatg aggatcaccc atgtgtgggt atccttacct attgaaaagt      120

aataggtcaa ggaatgcaac tggttgccca ccctagtcat tg                         162


<210> 190
<211> 147
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 190
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctatta aaagtaatag gtcaaggaat      120

gcaactggtt gcccacccta gtcattg                                          147


<210> 191
<211> 150
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 191
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg gaaaagctaa taggtcaagg      120

aatgcaactg gttgcccacc ctagtcattg                                       150


<210> 192
<211> 152
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 192
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg ctaaaagagt aataggtcaa      120

ggaatgcaac tggttgccca ccctagtcat tg                                    152


<210> 193
<211> 152
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 193
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg tgaaaagcat aataggtcaa      120

ggaatgcaac tggttgccca ccctagtcat tg                                    152


<210> 194
<211> 154
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 194
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg ctgaaaagca gtaataggtc      120

aaggaatgca actggttgcc caccctagtc attg                                  154


<210> 195
<211> 156
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 195
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg gctgaaaagc agctaatagg      120

tcaaggaatg caactggttg cccaccctag tcattg                                156


<210> 196
<211> 158
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 196
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg tgctgaaaag cagcataata      120

ggtcaaggaa tgcaactggt tgcccaccct agtcattg                              158


<210> 197
<211> 160
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 197
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgttg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctatta catgaggatc acccatgtaa      120

taggtcaagg aatgcaactg gttgcccacc ctagtcattg                            160


<210> 198
<211> 154
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 198
gctccacttg ctaatgcaag tggtgccttc caaagctata tgctgaggga ggatgggcgc       60

tgcggcatgc gtctgcccac ctcagagtgg gtatccttac ctattgaaaa gtaataggtc      120

aaggaatgcc gctggttgcc caccctagtc attg                                  154


<210> 199
<211> 150
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 199
gctccgcttt aataagcggt gccttccaaa gctatatgct gagggaggat gggcgctgcc       60

gcatgcgtct gcccacctca gagtgggtat ccttacctat tgaaaagtaa taggtcaagg      120

aatgcggctg gttgcccacc ctagtcattg                                       150


<210> 200
<211> 150
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 200
gcaccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgcc       60

gcatgcgtct gcccacctca gagtgggtat ccttacctat tgaaaagtaa taggtcaagg      120

aatgcggctg gttgcccacc ctagtcattg                                       150


<210> 201
<211> 150
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 201
gctccactgt aatcagtggt gccttccaaa gctatatgct gagggaggat gggcgctgcc       60

gcatgcgtct gcccacctca gagtgggtat ccttacctat tgaaaagtaa taggtcaagg      120

aatgcggctg gttgcccacc ctagtcattg                                       150


<210> 202
<211> 154
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 202
gctccacttg ctaatgcaag tggtgccttc caaagctata tgctgaggga ggatgggcgc       60

tgccgcatgc gtctgcccac ctcagagtgg gtatccttac ctattgaaaa gtaataggtc      120

aaggaatgcg gctggttgcc caccctagtc attg                                  154


<210> 203
<211> 165
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 203
gctccactta catgaggatc acccatgtaa gtggtgcctt ccaaagctat atgctgaggg       60

aggatgggcg ctgccgcatg cgtctgccca cctcagagtg ggtatcctta cctattgaaa      120

agtaataggt caaggaatgc ggctggttgc ccaccctagt cattg                      165


<210> 204
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 204
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgccg       60

catgcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcggctgg ttgcccaccc tagtcattg                                        149


<210> 205
<211> 150
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 205
gctccgcttt aataagcggt gccttccaaa gctatatgct gagggaggat gggcgctgcg       60

gcatgcgtct gcccacctca gagtgggtat ccttacctat tgaaaagtaa taggtcaagg      120

aatgccgctg gttgcccacc ctagtcattg                                       150


<210> 206
<211> 150
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 206
gcaccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgcg       60

gcatgcgtct gcccacctca gagtgggtat ccttacctat tgaaaagtaa taggtcaagg      120

aatgccgctg gttgcccacc ctagtcattg                                       150


<210> 207
<211> 150
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 207
gctccactgt aatcagtggt gccttccaaa gctatatgct gagggaggat gggcgctgcg       60

gcatgcgtct gcccacctca gagtgggtat ccttacctat tgaaaagtaa taggtcaagg      120

aatgccgctg gttgcccacc ctagtcattg                                       150


<210> 208
<211> 165
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 208
gctccactta catgaggatc acccatgtaa gtggtgcctt ccaaagctat atgctgaggg       60

aggatgggcg ctgcggcatg cgtctgccca cctcagagtg ggtatcctta cctattgaaa      120

agtaataggt caaggaatgc cgctggttgc ccaccctagt cattg                      165


<210> 209
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 209
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgcgg       60

catgcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgccgctgg ttgcccaccc tagtcattg                                        149


<210> 210
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 210
gctccgcttt aataagcggt gccttccaaa gctatatgct gagggaggat gggcgctgcc       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcggctgg ttgcccaccc tagtcattg                                        149


<210> 211
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 211
gcaccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgcc       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcggctgg ttgcccaccc tagtcattg                                        149


<210> 212
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 212
gctccactgt aatcagtggt gccttccaaa gctatatgct gagggaggat gggcgctgcc       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcggctgg ttgcccaccc tagtcattg                                        149


<210> 213
<211> 153
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 213
gctccacttg ctaatgcaag tggtgccttc caaagctata tgctgaggga ggatgggcgc       60

tgccgcagcg tctgcccacc tcagagtggg tatccttacc tattgaaaag taataggtca      120

aggaatgcgg ctggttgccc accctagtca ttg                                   153


<210> 214
<211> 164
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 214
gctccactta catgaggatc acccatgtaa gtggtgcctt ccaaagctat atgctgaggg       60

aggatgggcg ctgccgcagc gtctgcccac ctcagagtgg gtatccttac ctattgaaaa      120

gtaataggtc aaggaatgcg gctggttgcc caccctagtc attg                       164


<210> 215
<211> 148
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 215
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgccg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg aaaagtaata ggtcaaggaa      120

tgcggctggt tgcccaccct agtcattg                                         148


<210> 216
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 216
gctccgcttt aataagcggt gccttccaaa gctatatgct gagggaggat gggcgctgcg       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgccgctgg ttgcccaccc tagtcattg                                        149


<210> 217
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 217
gcaccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgcg       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgccgctgg ttgcccaccc tagtcattg                                        149


<210> 218
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 218
gctccactgt aatcagtggt gccttccaaa gctatatgct gagggaggat gggcgctgcg       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgccgctgg ttgcccaccc tagtcattg                                        149


<210> 219
<211> 153
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 219
gctccacttg ctaatgcaag tggtgccttc caaagctata tgctgaggga ggatgggcgc       60

tgcggcagcg tctgcccacc tcagagtggg tatccttacc tattgaaaag taataggtca      120

aggaatgccg ctggttgccc accctagtca ttg                                   153


<210> 220
<211> 164
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 220
gctccactta catgaggatc acccatgtaa gtggtgcctt ccaaagctat atgctgaggg       60

aggatgggcg ctgcggcagc gtctgcccac ctcagagtgg gtatccttac ctattgaaaa      120

gtaataggtc aaggaatgcc gctggttgcc caccctagtc attg                       164


<210> 221
<211> 148
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 221
gtccacttta ataagtggtg ccttccaaag ctatatgctg agggaggatg ggcgctgcgg       60

cagcgtctgc ccacctcaga gtgggtatcc ttacctattg aaaagtaata ggtcaaggaa      120

tgccgctggt tgcccaccct agtcattg                                         148


<210> 222
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 222
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaactgg ttgcccaccc tagtcattg                                        149


<210> 223
<211> 147
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 223
tccactttaa taagtggtgc cttccaaagc tatatgctga gggaggatgg gcgctgttgc       60

agcgtctgcc cacctcagag tgggtatcct tacctattga aaagtaatag gtcaaggaat      120

gcaactggtt gcccacccta gtcattg                                          147


<210> 224
<211> 129
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 224
gccttccaaa gctatatgct gagggaggat gggcgctgtt gcagcgtctg cccacctcag       60

agtgggtatc cttacctatt gaaaagtaat aggtcaagga atgcaactgg ttgcccaccc      120

tagtcattg                                                              129


<210> 225
<211> 152
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 225
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaactgg ttgcccaccc tagtcattgg ag                                    152


<210> 226
<211> 151
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 226
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaactgg ttgcccaccc tagtcattgg a                                     151


<210> 227
<211> 150
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 227
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaactgg ttgcccaccc tagtcattgg                                       150


<210> 228
<211> 149
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 228
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaactgg ttgcccaccc tagtcattg                                        149


<210> 229
<211> 148
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 229
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaactgg ttgcccaccc tagtcatt                                         148


<210> 230
<211> 147
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 230
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaactgg ttgcccaccc tagtcat                                          147


<210> 231
<211> 146
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 231
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaactgg ttgcccaccc tagtca                                           146


<210> 232
<211> 145
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 232
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctcag agtgggtatc cttacctatt gaaaagtaat aggtcaagga      120

atgcaactgg ttgcccaccc tagtc                                            145


<210> 233
<211> 597
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 233
Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile 
1               5                   10                  15      


Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe 
            20                  25                  30          


Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser 
        35                  40                  45              


Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp 
    50                  55                  60                  


Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Gly Ser Pro 
65                  70                  75                  80  


Lys Lys Lys Arg Lys Val Ser Gly Val Trp Leu Asp Gly Val Asn Ile 
                85                  90                  95      


Phe Ser Val Ser Ile Leu Leu Val Ser Ala Trp Leu Glu Phe Lys Gly 
            100                 105                 110         


Phe Val Arg Ala His Ile Cys Lys Thr Cys Tyr Ser Gly Val Ala Gly 
        115                 120                 125             


Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn Asp Lys Glu Gly Trp 
    130                 135                 140                 


Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn Ala Pro Gly Leu Thr 
145                 150                 155                 160 


Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile Ser Ile Leu Arg 
                165                 170                 175     


Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg Ile Ile Glu Tyr 
            180                 185                 190         


Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp Asp Val Glu Lys 
        195                 200                 205             


Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu Gly His Gln Arg 
    210                 215                 220                 


Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu Lys Trp Gln Gly Ile 
225                 230                 235                 240 


Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu Lys Arg Ile 
                245                 250                 255     


Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg Pro Tyr Val 
            260                 265                 270         


Glu Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr Glu Thr Val Glu 
        275                 280                 285             


Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala Ser Ile Ser 
    290                 295                 300                 


Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser Ile Glu Tyr 
305                 310                 315                 320 


Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu Glu Thr Tyr 
                325                 330                 335     


Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln Tyr Pro Val 
            340                 345                 350         


Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe Lys Ala Phe 
        355                 360                 365             


Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys Ile Ile Ser 
    370                 375                 380                 


Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe His Gly Lys 
385                 390                 395                 400 


Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg Asp Arg Leu 
                405                 410                 415     


Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys Lys Ile Arg 
            420                 425                 430         


Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val Lys Tyr Phe 
        435                 440                 445             


Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val Glu Ile Ala 
    450                 455                 460                 


Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu Arg Tyr Leu 
465                 470                 475                 480 


Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys Ala Lys Lys 
                485                 490                 495     


Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu Ile Asp Met 
            500                 505                 510         


Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met Ile Ile Asp 
        515                 520                 525             


Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr Val Asp Glu 
    530                 535                 540                 


Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys Gly Tyr Ser 
545                 550                 555                 560 


Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys Ala Phe Tyr 
                565                 570                 575     


Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala Tyr Val Cys 
            580                 585                 590         


Ser Glu Pro Asp Lys 
        595         


<210> 234
<211> 597
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 234
Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile 
1               5                   10                  15      


Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe 
            20                  25                  30          


Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser 
        35                  40                  45              


Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp 
    50                  55                  60                  


Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Val Trp Leu 
65                  70                  75                  80  


Asp Gly Val Asn Ile Phe Ser Val Ser Ile Leu Leu Val Ser Ala Trp 
                85                  90                  95      


Leu Glu Phe Lys Gly Phe Val Arg Gly Ser Pro Lys Lys Lys Arg Lys 
            100                 105                 110         


Val Ser Gly Ala His Ile Cys Lys Thr Cys Tyr Ser Gly Val Ala Gly 
        115                 120                 125             


Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn Asp Lys Glu Gly Trp 
    130                 135                 140                 


Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn Ala Pro Gly Leu Thr 
145                 150                 155                 160 


Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile Ser Ile Leu Arg 
                165                 170                 175     


Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg Ile Ile Glu Tyr 
            180                 185                 190         


Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp Asp Val Glu Lys 
        195                 200                 205             


Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu Gly His Gln Arg 
    210                 215                 220                 


Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu Lys Trp Gln Gly Ile 
225                 230                 235                 240 


Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu Lys Arg Ile 
                245                 250                 255     


Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg Pro Tyr Val 
            260                 265                 270         


Glu Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr Glu Thr Val Glu 
        275                 280                 285             


Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala Ser Ile Ser 
    290                 295                 300                 


Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser Ile Glu Tyr 
305                 310                 315                 320 


Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu Glu Thr Tyr 
                325                 330                 335     


Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln Tyr Pro Val 
            340                 345                 350         


Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe Lys Ala Phe 
        355                 360                 365             


Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys Ile Ile Ser 
    370                 375                 380                 


Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe His Gly Lys 
385                 390                 395                 400 


Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg Asp Arg Leu 
                405                 410                 415     


Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys Lys Ile Arg 
            420                 425                 430         


Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val Lys Tyr Phe 
        435                 440                 445             


Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val Glu Ile Ala 
    450                 455                 460                 


Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu Arg Tyr Leu 
465                 470                 475                 480 


Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys Ala Lys Lys 
                485                 490                 495     


Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu Ile Asp Met 
            500                 505                 510         


Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met Ile Ile Asp 
        515                 520                 525             


Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr Val Asp Glu 
    530                 535                 540                 


Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys Gly Tyr Ser 
545                 550                 555                 560 


Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys Ala Phe Tyr 
                565                 570                 575     


Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala Tyr Val Cys 
            580                 585                 590         


Ser Glu Pro Asp Lys 
        595         


<210> 235
<211> 597
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 235
Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile 
1               5                   10                  15      


Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe 
            20                  25                  30          


Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser 
        35                  40                  45              


Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp 
    50                  55                  60                  


Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Val Trp Leu 
65                  70                  75                  80  


Asp Gly Val Asn Ile Phe Ser Val Ser Ile Leu Leu Val Ser Ala Trp 
                85                  90                  95      


Leu Glu Phe Lys Gly Phe Val Arg Ala His Ile Cys Lys Thr Cys Tyr 
            100                 105                 110         


Ser Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn 
        115                 120                 125             


Asp Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn 
    130                 135                 140                 


Ala Pro Gly Ser Pro Lys Lys Lys Arg Lys Val Ser Gly Gly Leu Thr 
145                 150                 155                 160 


Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile Ser Ile Leu Arg 
                165                 170                 175     


Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg Ile Ile Glu Tyr 
            180                 185                 190         


Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp Asp Val Glu Lys 
        195                 200                 205             


Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu Gly His Gln Arg 
    210                 215                 220                 


Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu Lys Trp Gln Gly Ile 
225                 230                 235                 240 


Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu Lys Arg Ile 
                245                 250                 255     


Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg Pro Tyr Val 
            260                 265                 270         


Glu Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr Glu Thr Val Glu 
        275                 280                 285             


Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala Ser Ile Ser 
    290                 295                 300                 


Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser Ile Glu Tyr 
305                 310                 315                 320 


Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu Glu Thr Tyr 
                325                 330                 335     


Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln Tyr Pro Val 
            340                 345                 350         


Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe Lys Ala Phe 
        355                 360                 365             


Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys Ile Ile Ser 
    370                 375                 380                 


Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe His Gly Lys 
385                 390                 395                 400 


Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg Asp Arg Leu 
                405                 410                 415     


Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys Lys Ile Arg 
            420                 425                 430         


Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val Lys Tyr Phe 
        435                 440                 445             


Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val Glu Ile Ala 
    450                 455                 460                 


Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu Arg Tyr Leu 
465                 470                 475                 480 


Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys Ala Lys Lys 
                485                 490                 495     


Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu Ile Asp Met 
            500                 505                 510         


Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met Ile Ile Asp 
        515                 520                 525             


Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr Val Asp Glu 
    530                 535                 540                 


Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys Gly Tyr Ser 
545                 550                 555                 560 


Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys Ala Phe Tyr 
                565                 570                 575     


Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala Tyr Val Cys 
            580                 585                 590         


Ser Glu Pro Asp Lys 
        595         


<210> 236
<211> 597
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 236
Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile 
1               5                   10                  15      


Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe 
            20                  25                  30          


Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser 
        35                  40                  45              


Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp 
    50                  55                  60                  


Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Val Trp Leu 
65                  70                  75                  80  


Asp Gly Val Asn Ile Phe Ser Val Ser Ile Leu Leu Val Ser Ala Trp 
                85                  90                  95      


Leu Glu Phe Lys Gly Phe Val Arg Ala His Ile Cys Lys Thr Cys Tyr 
            100                 105                 110         


Ser Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn 
        115                 120                 125             


Asp Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn 
    130                 135                 140                 


Ala Pro Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala 
145                 150                 155                 160 


Ile Ser Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg 
                165                 170                 175     


Arg Ile Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile 
            180                 185                 190         


Asp Asp Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys 
        195                 200                 205             


Glu Gly His Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu 
    210                 215                 220                 


Gly Ser Pro Lys Lys Lys Arg Lys Val Ser Gly Lys Trp Gln Gly Ile 
225                 230                 235                 240 


Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu Lys Arg Ile 
                245                 250                 255     


Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg Pro Tyr Val 
            260                 265                 270         


Glu Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr Glu Thr Val Glu 
        275                 280                 285             


Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala Ser Ile Ser 
    290                 295                 300                 


Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser Ile Glu Tyr 
305                 310                 315                 320 


Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu Glu Thr Tyr 
                325                 330                 335     


Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln Tyr Pro Val 
            340                 345                 350         


Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe Lys Ala Phe 
        355                 360                 365             


Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys Ile Ile Ser 
    370                 375                 380                 


Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe His Gly Lys 
385                 390                 395                 400 


Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg Asp Arg Leu 
                405                 410                 415     


Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys Lys Ile Arg 
            420                 425                 430         


Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val Lys Tyr Phe 
        435                 440                 445             


Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val Glu Ile Ala 
    450                 455                 460                 


Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu Arg Tyr Leu 
465                 470                 475                 480 


Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys Ala Lys Lys 
                485                 490                 495     


Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu Ile Asp Met 
            500                 505                 510         


Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met Ile Ile Asp 
        515                 520                 525             


Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr Val Asp Glu 
    530                 535                 540                 


Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys Gly Tyr Ser 
545                 550                 555                 560 


Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys Ala Phe Tyr 
                565                 570                 575     


Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala Tyr Val Cys 
            580                 585                 590         


Ser Glu Pro Asp Lys 
        595         


<210> 237
<211> 597
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 237
Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile 
1               5                   10                  15      


Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe 
            20                  25                  30          


Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser 
        35                  40                  45              


Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp 
    50                  55                  60                  


Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Val Trp Leu 
65                  70                  75                  80  


Asp Gly Val Asn Ile Phe Ser Val Ser Ile Leu Leu Val Ser Ala Trp 
                85                  90                  95      


Leu Glu Phe Lys Gly Phe Val Arg Ala His Ile Cys Lys Thr Cys Tyr 
            100                 105                 110         


Ser Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn 
        115                 120                 125             


Asp Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn 
    130                 135                 140                 


Ala Pro Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala 
145                 150                 155                 160 


Ile Ser Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg 
                165                 170                 175     


Arg Ile Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile 
            180                 185                 190         


Asp Asp Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys 
        195                 200                 205             


Glu Gly His Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu 
    210                 215                 220                 


Lys Trp Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp 
225                 230                 235                 240 


Ile Glu Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu 
                245                 250                 255     


Asn Arg Pro Tyr Val Glu Leu His Lys Asn Gly Ser Pro Lys Lys Lys 
            260                 265                 270         


Arg Lys Val Ser Gly Asn Val Arg Ile Val Gly Tyr Glu Thr Val Glu 
        275                 280                 285             


Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala Ser Ile Ser 
    290                 295                 300                 


Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser Ile Glu Tyr 
305                 310                 315                 320 


Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu Glu Thr Tyr 
                325                 330                 335     


Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln Tyr Pro Val 
            340                 345                 350         


Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe Lys Ala Phe 
        355                 360                 365             


Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys Ile Ile Ser 
    370                 375                 380                 


Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe His Gly Lys 
385                 390                 395                 400 


Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg Asp Arg Leu 
                405                 410                 415     


Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys Lys Ile Arg 
            420                 425                 430         


Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val Lys Tyr Phe 
        435                 440                 445             


Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val Glu Ile Ala 
    450                 455                 460                 


Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu Arg Tyr Leu 
465                 470                 475                 480 


Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys Ala Lys Lys 
                485                 490                 495     


Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu Ile Asp Met 
            500                 505                 510         


Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met Ile Ile Asp 
        515                 520                 525             


Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr Val Asp Glu 
    530                 535                 540                 


Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys Gly Tyr Ser 
545                 550                 555                 560 


Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys Ala Phe Tyr 
                565                 570                 575     


Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala Tyr Val Cys 
            580                 585                 590         


Ser Glu Pro Asp Lys 
        595         


<210> 238
<211> 597
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 238
Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile 
1               5                   10                  15      


Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe 
            20                  25                  30          


Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser 
        35                  40                  45              


Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp 
    50                  55                  60                  


Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Val Trp Leu 
65                  70                  75                  80  


Asp Gly Val Asn Ile Phe Ser Val Ser Ile Leu Leu Val Ser Ala Trp 
                85                  90                  95      


Leu Glu Phe Lys Gly Phe Val Arg Ala His Ile Cys Lys Thr Cys Tyr 
            100                 105                 110         


Ser Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn 
        115                 120                 125             


Asp Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn 
    130                 135                 140                 


Ala Pro Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala 
145                 150                 155                 160 


Ile Ser Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg 
                165                 170                 175     


Arg Ile Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile 
            180                 185                 190         


Asp Asp Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys 
        195                 200                 205             


Glu Gly His Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu 
    210                 215                 220                 


Lys Trp Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp 
225                 230                 235                 240 


Ile Glu Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu 
                245                 250                 255     


Asn Arg Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly 
            260                 265                 270         


Tyr Glu Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His 
        275                 280                 285             


Phe Ala Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys 
    290                 295                 300                 


Lys Ser Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg 
305                 310                 315                 320 


Asn Leu Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe 
                325                 330                 335     


Leu Gln Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys 
            340                 345                 350         


Asn Phe Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val 
        355                 360                 365             


Gly Cys Ile Ile Ser Lys Asp Gly Ser Pro Lys Lys Lys Arg Lys Val 
    370                 375                 380                 


Ser Gly Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe His Gly Lys 
385                 390                 395                 400 


Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg Asp Arg Leu 
                405                 410                 415     


Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys Lys Ile Arg 
            420                 425                 430         


Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val Lys Tyr Phe 
        435                 440                 445             


Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val Glu Ile Ala 
    450                 455                 460                 


Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu Arg Tyr Leu 
465                 470                 475                 480 


Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys Ala Lys Lys 
                485                 490                 495     


Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu Ile Asp Met 
            500                 505                 510         


Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met Ile Ile Asp 
        515                 520                 525             


Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr Val Asp Glu 
    530                 535                 540                 


Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys Gly Tyr Ser 
545                 550                 555                 560 


Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys Ala Phe Tyr 
                565                 570                 575     


Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala Tyr Val Cys 
            580                 585                 590         


Ser Glu Pro Asp Lys 
        595         


<210> 239
<211> 637
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 239
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu 
            20                  25                  30          


Lys Leu Ile Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe 
        35                  40                  45              


Ile Thr Phe Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp 
    50                  55                  60                  


Ile Arg Ser Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala 
65                  70                  75                  80  


Val Cys Asp Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile 
                85                  90                  95      


Gly Ser Pro Lys Lys Lys Arg Lys Val Ser Gly Val Trp Leu Asp Gly 
            100                 105                 110         


Val Asn Ile Phe Ser Val Ser Ile Leu Leu Val Ser Ala Trp Leu Glu 
        115                 120                 125             


Phe Lys Gly Phe Val Arg Ala His Ile Cys Lys Thr Cys Tyr Ser Gly 
    130                 135                 140                 


Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn Asp Lys 
145                 150                 155                 160 


Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn Ala Pro 
                165                 170                 175     


Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile Ser 
            180                 185                 190         


Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg Ile 
        195                 200                 205             


Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp Asp 
    210                 215                 220                 


Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu Gly 
225                 230                 235                 240 


His Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu Lys Trp 
                245                 250                 255     


Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu 
            260                 265                 270         


Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg 
        275                 280                 285             


Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr Glu 
    290                 295                 300                 


Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala 
305                 310                 315                 320 


Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser 
                325                 330                 335     


Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu 
            340                 345                 350         


Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln 
        355                 360                 365             


Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe 
    370                 375                 380                 


Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys 
385                 390                 395                 400 


Ile Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe 
                405                 410                 415     


His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg 
            420                 425                 430         


Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys 
        435                 440                 445             


Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val 
    450                 455                 460                 


Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val 
465                 470                 475                 480 


Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu 
                485                 490                 495     


Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys 
            500                 505                 510         


Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu 
        515                 520                 525             


Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met 
    530                 535                 540                 


Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr 
545                 550                 555                 560 


Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys 
                565                 570                 575     


Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys 
            580                 585                 590         


Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala 
        595                 600                 605             


Tyr Val Cys Ser Glu Pro Asp Lys Ser Gly Gly Ser Lys Arg Thr Ala 
    610                 615                 620                 


Asp Gly Ser Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
625                 630                 635         


<210> 240
<211> 637
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 240
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu 
            20                  25                  30          


Lys Leu Ile Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe 
        35                  40                  45              


Ile Thr Phe Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp 
    50                  55                  60                  


Ile Arg Ser Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala 
65                  70                  75                  80  


Val Cys Asp Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile 
                85                  90                  95      


Val Trp Leu Asp Gly Val Asn Ile Phe Ser Val Ser Ile Leu Leu Val 
            100                 105                 110         


Ser Ala Trp Leu Glu Phe Lys Gly Phe Val Arg Gly Ser Pro Lys Lys 
        115                 120                 125             


Lys Arg Lys Val Ser Gly Ala His Ile Cys Lys Thr Cys Tyr Ser Gly 
    130                 135                 140                 


Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn Asp Lys 
145                 150                 155                 160 


Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn Ala Pro 
                165                 170                 175     


Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile Ser 
            180                 185                 190         


Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg Ile 
        195                 200                 205             


Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp Asp 
    210                 215                 220                 


Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu Gly 
225                 230                 235                 240 


His Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu Lys Trp 
                245                 250                 255     


Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu 
            260                 265                 270         


Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg 
        275                 280                 285             


Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr Glu 
    290                 295                 300                 


Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala 
305                 310                 315                 320 


Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser 
                325                 330                 335     


Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu 
            340                 345                 350         


Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln 
        355                 360                 365             


Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe 
    370                 375                 380                 


Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys 
385                 390                 395                 400 


Ile Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe 
                405                 410                 415     


His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg 
            420                 425                 430         


Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys 
        435                 440                 445             


Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val 
    450                 455                 460                 


Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val 
465                 470                 475                 480 


Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu 
                485                 490                 495     


Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys 
            500                 505                 510         


Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu 
        515                 520                 525             


Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met 
    530                 535                 540                 


Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr 
545                 550                 555                 560 


Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys 
                565                 570                 575     


Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys 
            580                 585                 590         


Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala 
        595                 600                 605             


Tyr Val Cys Ser Glu Pro Asp Lys Ser Gly Gly Ser Lys Arg Thr Ala 
    610                 615                 620                 


Asp Gly Ser Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
625                 630                 635         


<210> 241
<211> 637
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 241
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu 
            20                  25                  30          


Lys Leu Ile Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe 
        35                  40                  45              


Ile Thr Phe Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp 
    50                  55                  60                  


Ile Arg Ser Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala 
65                  70                  75                  80  


Val Cys Asp Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile 
                85                  90                  95      


Val Trp Leu Asp Gly Val Asn Ile Phe Ser Val Ser Ile Leu Leu Val 
            100                 105                 110         


Ser Ala Trp Leu Glu Phe Lys Gly Phe Val Arg Ala His Ile Cys Lys 
        115                 120                 125             


Thr Cys Tyr Ser Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met 
    130                 135                 140                 


Tyr Pro Asn Asp Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile 
145                 150                 155                 160 


Lys Val Asn Ala Pro Gly Ser Pro Lys Lys Lys Arg Lys Val Ser Gly 
                165                 170                 175     


Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile Ser 
            180                 185                 190         


Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg Ile 
        195                 200                 205             


Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp Asp 
    210                 215                 220                 


Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu Gly 
225                 230                 235                 240 


His Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu Lys Trp 
                245                 250                 255     


Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu 
            260                 265                 270         


Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg 
        275                 280                 285             


Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr Glu 
    290                 295                 300                 


Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala 
305                 310                 315                 320 


Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser 
                325                 330                 335     


Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu 
            340                 345                 350         


Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln 
        355                 360                 365             


Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe 
    370                 375                 380                 


Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys 
385                 390                 395                 400 


Ile Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe 
                405                 410                 415     


His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg 
            420                 425                 430         


Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys 
        435                 440                 445             


Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val 
    450                 455                 460                 


Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val 
465                 470                 475                 480 


Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu 
                485                 490                 495     


Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys 
            500                 505                 510         


Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu 
        515                 520                 525             


Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met 
    530                 535                 540                 


Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr 
545                 550                 555                 560 


Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys 
                565                 570                 575     


Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys 
            580                 585                 590         


Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala 
        595                 600                 605             


Tyr Val Cys Ser Glu Pro Asp Lys Ser Gly Gly Ser Lys Arg Thr Ala 
    610                 615                 620                 


Asp Gly Ser Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
625                 630                 635         


<210> 242
<211> 637
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 242
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu 
            20                  25                  30          


Lys Leu Ile Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe 
        35                  40                  45              


Ile Thr Phe Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp 
    50                  55                  60                  


Ile Arg Ser Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala 
65                  70                  75                  80  


Val Cys Asp Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile 
                85                  90                  95      


Val Trp Leu Asp Gly Val Asn Ile Phe Ser Val Ser Ile Leu Leu Val 
            100                 105                 110         


Ser Ala Trp Leu Glu Phe Lys Gly Phe Val Arg Ala His Ile Cys Lys 
        115                 120                 125             


Thr Cys Tyr Ser Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met 
    130                 135                 140                 


Tyr Pro Asn Asp Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile 
145                 150                 155                 160 


Lys Val Asn Ala Pro Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile 
                165                 170                 175     


Arg Lys Ala Ile Ser Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn 
            180                 185                 190         


Ala Glu Arg Arg Ile Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu 
        195                 200                 205             


Glu Leu Ile Asp Asp Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val 
    210                 215                 220                 


Leu Glu Lys Glu Gly His Gln Arg Val Lys Arg Tyr Lys His Lys Asn 
225                 230                 235                 240 


Trp Pro Glu Gly Ser Pro Lys Lys Lys Arg Lys Val Ser Gly Lys Trp 
                245                 250                 255     


Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu 
            260                 265                 270         


Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg 
        275                 280                 285             


Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr Glu 
    290                 295                 300                 


Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala 
305                 310                 315                 320 


Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser 
                325                 330                 335     


Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu 
            340                 345                 350         


Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln 
        355                 360                 365             


Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe 
    370                 375                 380                 


Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys 
385                 390                 395                 400 


Ile Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe 
                405                 410                 415     


His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg 
            420                 425                 430         


Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys 
        435                 440                 445             


Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val 
    450                 455                 460                 


Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val 
465                 470                 475                 480 


Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu 
                485                 490                 495     


Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys 
            500                 505                 510         


Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu 
        515                 520                 525             


Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met 
    530                 535                 540                 


Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr 
545                 550                 555                 560 


Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys 
                565                 570                 575     


Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys 
            580                 585                 590         


Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala 
        595                 600                 605             


Tyr Val Cys Ser Glu Pro Asp Lys Ser Gly Gly Ser Lys Arg Thr Ala 
    610                 615                 620                 


Asp Gly Ser Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
625                 630                 635         


<210> 243
<211> 637
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 243
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu 
            20                  25                  30          


Lys Leu Ile Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe 
        35                  40                  45              


Ile Thr Phe Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp 
    50                  55                  60                  


Ile Arg Ser Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala 
65                  70                  75                  80  


Val Cys Asp Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile 
                85                  90                  95      


Val Trp Leu Asp Gly Val Asn Ile Phe Ser Val Ser Ile Leu Leu Val 
            100                 105                 110         


Ser Ala Trp Leu Glu Phe Lys Gly Phe Val Arg Ala His Ile Cys Lys 
        115                 120                 125             


Thr Cys Tyr Ser Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met 
    130                 135                 140                 


Tyr Pro Asn Asp Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile 
145                 150                 155                 160 


Lys Val Asn Ala Pro Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile 
                165                 170                 175     


Arg Lys Ala Ile Ser Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn 
            180                 185                 190         


Ala Glu Arg Arg Ile Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu 
        195                 200                 205             


Glu Leu Ile Asp Asp Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val 
    210                 215                 220                 


Leu Glu Lys Glu Gly His Gln Arg Val Lys Arg Tyr Lys His Lys Asn 
225                 230                 235                 240 


Trp Pro Glu Lys Trp Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys 
                245                 250                 255     


Val Lys Asp Ile Glu Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His 
            260                 265                 270         


Pro Thr Leu Asn Arg Pro Tyr Val Glu Leu His Lys Asn Gly Ser Pro 
        275                 280                 285             


Lys Lys Lys Arg Lys Val Ser Gly Asn Val Arg Ile Val Gly Tyr Glu 
    290                 295                 300                 


Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala 
305                 310                 315                 320 


Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser 
                325                 330                 335     


Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu 
            340                 345                 350         


Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln 
        355                 360                 365             


Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe 
    370                 375                 380                 


Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys 
385                 390                 395                 400 


Ile Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe 
                405                 410                 415     


His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg 
            420                 425                 430         


Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys 
        435                 440                 445             


Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val 
    450                 455                 460                 


Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val 
465                 470                 475                 480 


Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu 
                485                 490                 495     


Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys 
            500                 505                 510         


Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu 
        515                 520                 525             


Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met 
    530                 535                 540                 


Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr 
545                 550                 555                 560 


Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys 
                565                 570                 575     


Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys 
            580                 585                 590         


Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala 
        595                 600                 605             


Tyr Val Cys Ser Glu Pro Asp Lys Ser Gly Gly Ser Lys Arg Thr Ala 
    610                 615                 620                 


Asp Gly Ser Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
625                 630                 635         


<210> 244
<211> 637
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 244
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu 
            20                  25                  30          


Lys Leu Ile Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe 
        35                  40                  45              


Ile Thr Phe Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp 
    50                  55                  60                  


Ile Arg Ser Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala 
65                  70                  75                  80  


Val Cys Asp Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile 
                85                  90                  95      


Val Trp Leu Asp Gly Val Asn Ile Phe Ser Val Ser Ile Leu Leu Val 
            100                 105                 110         


Ser Ala Trp Leu Glu Phe Lys Gly Phe Val Arg Ala His Ile Cys Lys 
        115                 120                 125             


Thr Cys Tyr Ser Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met 
    130                 135                 140                 


Tyr Pro Asn Asp Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile 
145                 150                 155                 160 


Lys Val Asn Ala Pro Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile 
                165                 170                 175     


Arg Lys Ala Ile Ser Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn 
            180                 185                 190         


Ala Glu Arg Arg Ile Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu 
        195                 200                 205             


Glu Leu Ile Asp Asp Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val 
    210                 215                 220                 


Leu Glu Lys Glu Gly His Gln Arg Val Lys Arg Tyr Lys His Lys Asn 
225                 230                 235                 240 


Trp Pro Glu Lys Trp Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys 
                245                 250                 255     


Val Lys Asp Ile Glu Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His 
            260                 265                 270         


Pro Thr Leu Asn Arg Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg 
        275                 280                 285             


Ile Val Gly Tyr Glu Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr 
    290                 295                 300                 


Thr Ile His Phe Ala Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys 
305                 310                 315                 320 


Gln Lys Lys Lys Ser Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala 
                325                 330                 335     


Leu Lys Arg Asn Leu Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys 
            340                 345                 350         


Asn Phe Phe Leu Gln Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys 
        355                 360                 365             


Leu Thr Lys Asn Phe Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg 
    370                 375                 380                 


Leu Ala Val Gly Cys Ile Ile Ser Lys Asp Gly Ser Pro Lys Lys Lys 
385                 390                 395                 400 


Arg Lys Val Ser Gly Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe 
                405                 410                 415     


His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg 
            420                 425                 430         


Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys 
        435                 440                 445             


Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val 
    450                 455                 460                 


Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val 
465                 470                 475                 480 


Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu 
                485                 490                 495     


Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys 
            500                 505                 510         


Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu 
        515                 520                 525             


Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met 
    530                 535                 540                 


Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr 
545                 550                 555                 560 


Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys 
                565                 570                 575     


Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys 
            580                 585                 590         


Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala 
        595                 600                 605             


Tyr Val Cys Ser Glu Pro Asp Lys Ser Gly Gly Ser Lys Arg Thr Ala 
    610                 615                 620                 


Asp Gly Ser Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
625                 630                 635         


<210> 245
<211> 154
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 245
gctccacttg ctaatgcaag tggtgccttc caaagctata tgctgaggga ggatgggcgc       60

tgcggcatgc gtctgcccac ctcagagtgg gtatccttac ctattgaaaa gtaataggtc      120

aaggaatgcc gctatgagtt acaacgaaca cctc                                  154


<210> 246
<211> 160
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 246
gctccacttg ctaatgcaag tggtgccttc caaaccaaag cctatatggc tgagggagga       60

tgggcgctgc cgcatgcgtc tgcccacctc agagtgggta tccttaccta ttaaaagtaa      120

taggtcaagg aatgcggctg gttgcccacc ctagtcattg                            160


<210> 247
<211> 153
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 247
gcaccacttt aataagtggt gccttccaaa gctgtatatc agctgaggga ggatgggcgc       60

tgccgcatgc gtctgcccac ctcagagtgg gtatccttac ctattaaaag taataggtca      120

aggaatgcgg ctggttgccc accctagtca ttg                                   153


<210> 248
<211> 157
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 248
gctccacttg ctaatgcaag tggtgccttc caaagctgta tatcagctga gggaggatgg       60

gcgctgccgc atgcgtctgc ccacctcaga gtgggtatcc ttacctatta aaagtaatag      120

gtcaaggaat gcggctggtt gcccacccta gtcattg                               157


<210> 249
<211> 155
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 249
gcaccacttt aataagtggt gccttccaaa gctgctatat gcagctgagg gaggatgggc       60

gctgccgcat gcgtctgccc acctcagagt gggtatcctt acctattaaa agtaataggt      120

caaggaatgc ggctggttgc ccaccctagt cattg                                 155


<210> 250
<211> 160
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 250
gctccacttg ctaatgcaag tggtgccttc caaaccaaag cctatatggc tgagggagga       60

tgggcgctgc ggcatgcgtc tgcccacctc agagtgggta tccttaccta ttaaaagtaa      120

taggtcaagg aatgccgctg gttgcccacc ctagtcattg                            160


<210> 251
<211> 153
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 251
gcaccacttt aataagtggt gccttccaaa gctgtatatc agctgaggga ggatgggcgc       60

tgcggcatgc gtctgcccac ctcagagtgg gtatccttac ctattaaaag taataggtca      120

aggaatgccg ctggttgccc accctagtca ttg                                   153


<210> 252
<211> 157
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 252
gctccacttg ctaatgcaag tggtgccttc caaagctgta tatcagctga gggaggatgg       60

gcgctgcggc atgcgtctgc ccacctcaga gtgggtatcc ttacctatta aaagtaatag      120

gtcaaggaat gccgctggtt gcccacccta gtcattg                               157


<210> 253
<211> 163
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 253
gctccacttg ctaatgcaag tggtgccttc caaaccaaag cctatatggc tgagggagga       60

tgggcgctgc cgcatgcgtc tgcccacctc agagtgggta tccttaccta ttggaaaagc      120

taataggtca aggaatgcgg ctggttgccc accctagtca ttg                        163


<210> 254
<211> 156
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 254
gcaccacttt aataagtggt gccttccaaa gctgtatatc agctgaggga ggatgggcgc       60

tgccgcatgc gtctgcccac ctcagagtgg gtatccttac ctattggaaa agctaatagg      120

tcaaggaatg cggctggttg cccaccctag tcattg                                156


<210> 255
<211> 160
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 255
gctccacttg ctaatgcaag tggtgccttc caaagctgta tatcagctga gggaggatgg       60

gcgctgccgc atgcgtctgc ccacctcaga gtgggtatcc ttacctattg gaaaagctaa      120

taggtcaagg aatgcggctg gttgcccacc ctagtcattg                            160


<210> 256
<211> 158
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 256
gcaccacttt aataagtggt gccttccaaa gctgctatat gcagctgagg gaggatgggc       60

gctgccgcat gcgtctgccc acctcagagt gggtatcctt acctattgga aaagctaata      120

ggtcaaggaa tgcggctggt tgcccaccct agtcattg                              158


<210> 257
<211> 163
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 257
gctccacttg ctaatgcaag tggtgccttc caaaccaaag cctatatggc tgagggagga       60

tgggcgctgc ggcatgcgtc tgcccacctc agagtgggta tccttaccta ttggaaaagc      120

taataggtca aggaatgccg ctggttgccc accctagtca ttg                        163


<210> 258
<211> 156
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 258
gcaccacttt aataagtggt gccttccaaa gctgtatatc agctgaggga ggatgggcgc       60

tgcggcatgc gtctgcccac ctcagagtgg gtatccttac ctattggaaa agctaatagg      120

tcaaggaatg ccgctggttg cccaccctag tcattg                                156


<210> 259
<211> 160
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 259
gctccacttg ctaatgcaag tggtgccttc caaagctgta tatcagctga gggaggatgg       60

gcgctgcggc atgcgtctgc ccacctcaga gtgggtatcc ttacctattg gaaaagctaa      120

taggtcaagg aatgccgctg gttgcccacc ctagtcattg                            160


<210> 260
<211> 158
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 260
gcaccacttt aataagtggt gccttccaaa gctgctatat gcagctgagg gaggatgggc       60

gctgcggcat gcgtctgccc acctcagagt gggtatcctt acctattgga aaagctaata      120

ggtcaaggaa tgccgctggt tgcccaccct agtcattg                              158


<210> 261
<211> 165
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 261
gctccacttg ctaatgcaag tggtgccttc caaaccaaag cctatatggc tgagggagga       60

tgggcgctgc cgcatgcgtc tgcccacctc agagtgggta tccttaccta ttgtgaaaag      120

cataataggt caaggaatgc ggctggttgc ccaccctagt cattg                      165


<210> 262
<211> 158
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 262
gcaccacttt aataagtggt gccttccaaa gctgtatatc agctgaggga ggatgggcgc       60

tgccgcatgc gtctgcccac ctcagagtgg gtatccttac ctattgtgaa aagcataata      120

ggtcaaggaa tgcggctggt tgcccaccct agtcattg                              158


<210> 263
<211> 162
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 263
gctccacttg ctaatgcaag tggtgccttc caaagctgta tatcagctga gggaggatgg       60

gcgctgccgc atgcgtctgc ccacctcaga gtgggtatcc ttacctattg tgaaaagcat      120

aataggtcaa ggaatgcggc tggttgccca ccctagtcat tg                         162


<210> 264
<211> 160
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 264
gcaccacttt aataagtggt gccttccaaa gctgctatat gcagctgagg gaggatgggc       60

gctgccgcat gcgtctgccc acctcagagt gggtatcctt acctattgtg aaaagcataa      120

taggtcaagg aatgcggctg gttgcccacc ctagtcattg                            160


<210> 265
<211> 165
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 265
gctccacttg ctaatgcaag tggtgccttc caaaccaaag cctatatggc tgagggagga       60

tgggcgctgc ggcatgcgtc tgcccacctc agagtgggta tccttaccta ttgtgaaaag      120

cataataggt caaggaatgc cgctggttgc ccaccctagt cattg                      165


<210> 266
<211> 158
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 266
gcaccacttt aataagtggt gccttccaaa gctgtatatc agctgaggga ggatgggcgc       60

tgcggcatgc gtctgcccac ctcagagtgg gtatccttac ctattgtgaa aagcataata      120

ggtcaaggaa tgccgctggt tgcccaccct agtcattg                              158


<210> 267
<211> 162
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 267
gctccacttg ctaatgcaag tggtgccttc caaagctgta tatcagctga gggaggatgg       60

gcgctgcggc atgcgtctgc ccacctcaga gtgggtatcc ttacctattg tgaaaagcat      120

aataggtcaa ggaatgccgc tggttgccca ccctagtcat tg                         162


<210> 268
<211> 160
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 268
gcaccacttt aataagtggt gccttccaaa gctgctatat gcagctgagg gaggatgggc       60

gctgcggcat gcgtctgccc acctcagagt gggtatcctt acctattgtg aaaagcataa      120

taggtcaagg aatgccgctg gttgcccacc ctagtcattg                            160


<210> 269
<211> 153
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 269
gctccgcttt aataagcggt gccttccaaa gctgtatatc agctgaggga ggatgggcgc       60

tgttgcagcg tctgcccacc tcagagtggg tatccttacc tattgaaaag taataggtca      120

aggaatgcaa ctggttgccc accctagtca ttg                                   153


<210> 270
<211> 153
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 270
gcaccacttt aataagtggt gccttccaaa gctgtatatc agctgaggga ggatgggcgc       60

tgttgcagcg tctgcccacc tcagagtggg tatccttacc tattgaaaag taataggtca      120

aggaatgcaa ctggttgccc accctagtca ttg                                   153


<210> 271
<211> 153
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 271
gctccactgt aatcagtggt gccttccaaa gctgtatatc agctgaggga ggatgggcgc       60

tgttgcagcg tctgcccacc tcagagtggg tatccttacc tattgaaaag taataggtca      120

aggaatgcaa ctggttgccc accctagtca ttg                                   153


<210> 272
<211> 157
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 272
gctccacttg ctaatgcaag tggtgccttc caaagctgta tatcagctga gggaggatgg       60

gcgctgttgc agcgtctgcc cacctcagag tgggtatcct tacctattga aaagtaatag      120

gtcaaggaat gcaactggtt gcccacccta gtcattg                               157


<210> 273
<211> 650
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 273
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Gly Gly Ser Ile Ser Asn Lys Thr Phe Lys Phe Lys 
            20                  25                  30          


Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys Asp Ile Tyr Thr Ile 
        35                  40                  45              


Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr Ser Gly Val Ala Gly 
    50                  55                  60                  


Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn Asp Lys Glu Gly Trp 
65                  70                  75                  80  


Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn Ala Pro Gly Leu Thr 
                85                  90                  95      


Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile Ser Ile Leu Arg 
            100                 105                 110         


Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg Ile Ile Glu Tyr 
        115                 120                 125             


Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp Asp Val Glu Lys 
    130                 135                 140                 


Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu Gly His Gln Arg 
145                 150                 155                 160 


Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu Lys Trp Gln Gly Ile 
                165                 170                 175     


Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu Lys Arg Ile 
            180                 185                 190         


Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg Pro Tyr Val 
        195                 200                 205             


Glu Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr Glu Thr Val Glu 
    210                 215                 220                 


Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala Ser Ile Ser 
225                 230                 235                 240 


Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser Ile Glu Tyr 
                245                 250                 255     


Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu Glu Thr Tyr 
            260                 265                 270         


Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln Tyr Pro Val 
        275                 280                 285             


Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe Lys Ala Phe 
    290                 295                 300                 


Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys Ile Ile Ser 
305                 310                 315                 320 


Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe His Gly Lys 
                325                 330                 335     


Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg Asp Arg Leu 
            340                 345                 350         


Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys Lys Ile Arg 
        355                 360                 365             


Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val Lys Tyr Phe 
    370                 375                 380                 


Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val Glu Ile Ala 
385                 390                 395                 400 


Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu Arg Tyr Leu 
                405                 410                 415     


Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys Ala Lys Lys 
            420                 425                 430         


Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu Ile Asp Met 
        435                 440                 445             


Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met Ile Ile Asp 
    450                 455                 460                 


Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr Val Asp Glu 
465                 470                 475                 480 


Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys Gly Tyr Ser 
                485                 490                 495     


Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys Ala Phe Tyr 
            500                 505                 510         


Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala Tyr Val Cys 
        515                 520                 525             


Ser Glu Pro Asp Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    530                 535                 540                 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Met Pro Ser Glu Thr Tyr Ile 
545                 550                 555                 560 


Thr Lys Thr Leu Ser Leu Lys Leu Ile Pro Ser Asp Glu Glu Lys Gln 
                565                 570                 575     


Ala Leu Glu Asn Tyr Phe Ile Thr Phe Gln Arg Ala Val Asn Phe Ala 
            580                 585                 590         


Ile Asp Arg Ile Val Asp Ile Arg Ser Ser Phe Arg Tyr Leu Asn Lys 
        595                 600                 605             


Asn Glu Gln Phe Pro Ala Val Cys Asp Cys Cys Gly Lys Lys Glu Lys 
    610                 615                 620                 


Ile Met Tyr Val Asn Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser 
625                 630                 635                 640 


Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
                645                 650 


<210> 274
<211> 650
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 274
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Gly Gly Ser Asn Ala His Ile Cys Lys Thr Cys Tyr 
            20                  25                  30          


Ser Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn 
        35                  40                  45              


Asp Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn 
    50                  55                  60                  


Ala Pro Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala 
65                  70                  75                  80  


Ile Ser Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg 
                85                  90                  95      


Arg Ile Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile 
            100                 105                 110         


Asp Asp Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys 
        115                 120                 125             


Glu Gly His Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu 
    130                 135                 140                 


Lys Trp Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp 
145                 150                 155                 160 


Ile Glu Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu 
                165                 170                 175     


Asn Arg Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly 
            180                 185                 190         


Tyr Glu Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His 
        195                 200                 205             


Phe Ala Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys 
    210                 215                 220                 


Lys Ser Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg 
225                 230                 235                 240 


Asn Leu Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe 
                245                 250                 255     


Leu Gln Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys 
            260                 265                 270         


Asn Phe Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val 
        275                 280                 285             


Gly Cys Ile Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe 
    290                 295                 300                 


Phe Phe His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys 
305                 310                 315                 320 


Ile Arg Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys 
                325                 330                 335     


Thr Lys Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His 
            340                 345                 350         


Lys Val Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln 
        355                 360                 365             


Ile Val Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu 
    370                 375                 380                 


Asp Leu Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser 
385                 390                 395                 400 


Lys Lys Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg 
                405                 410                 415     


Met Leu Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro 
            420                 425                 430         


Val Met Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys 
        435                 440                 445             


Gly Tyr Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu 
    450                 455                 460                 


Lys Cys Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile 
465                 470                 475                 480 


Ala Lys Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu 
                485                 490                 495     


His Ala Tyr Val Cys Ser Glu Pro Asp Lys Gly Gly Ser Gly Gly Ser 
            500                 505                 510         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Met Pro 
        515                 520                 525             


Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile Pro Ser 
    530                 535                 540                 


Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe Gln Arg 
545                 550                 555                 560 


Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser Ser Phe 
                565                 570                 575     


Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp Cys Cys 
            580                 585                 590         


Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys Thr Phe 
        595                 600                 605             


Lys Phe Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys Asp Ile 
    610                 615                 620                 


Tyr Thr Ile Lys Pro Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser 
625                 630                 635                 640 


Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
                645                 650 


<210> 275
<211> 650
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 275
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Gly Gly Ser Pro Gly Leu Thr Gly Thr Glu Tyr Ala 
            20                  25                  30          


Met Ala Ile Arg Lys Ala Ile Ser Ile Leu Arg Ser Phe Glu Lys Arg 
        35                  40                  45              


Arg Arg Asn Ala Glu Arg Arg Ile Ile Glu Tyr Glu Lys Ser Lys Lys 
    50                  55                  60                  


Glu Tyr Leu Glu Leu Ile Asp Asp Val Glu Lys Gly Lys Thr Asn Lys 
65                  70                  75                  80  


Ile Val Val Leu Glu Lys Glu Gly His Gln Arg Val Lys Arg Tyr Lys 
                85                  90                  95      


His Lys Asn Trp Pro Glu Lys Trp Gln Gly Ile Ser Leu Asn Lys Ala 
            100                 105                 110         


Lys Ser Lys Val Lys Asp Ile Glu Lys Arg Ile Lys Lys Leu Lys Glu 
        115                 120                 125             


Trp Lys His Pro Thr Leu Asn Arg Pro Tyr Val Glu Leu His Lys Asn 
    130                 135                 140                 


Asn Val Arg Ile Val Gly Tyr Glu Thr Val Glu Leu Lys Leu Gly Asn 
145                 150                 155                 160 


Lys Met Tyr Thr Ile His Phe Ala Ser Ile Ser Asn Leu Arg Lys Pro 
                165                 170                 175     


Phe Arg Lys Gln Lys Lys Lys Ser Ile Glu Tyr Leu Lys His Leu Leu 
            180                 185                 190         


Thr Leu Ala Leu Lys Arg Asn Leu Glu Thr Tyr Pro Ser Ile Ile Lys 
        195                 200                 205             


Arg Gly Lys Asn Phe Phe Leu Gln Tyr Pro Val Arg Val Thr Val Lys 
    210                 215                 220                 


Val Pro Lys Leu Thr Lys Asn Phe Lys Ala Phe Gly Ile Asp Arg Gly 
225                 230                 235                 240 


Val Asn Arg Leu Ala Val Gly Cys Ile Ile Ser Lys Asp Gly Lys Leu 
                245                 250                 255     


Thr Asn Lys Asn Ile Phe Phe Phe His Gly Lys Glu Ala Trp Ala Lys 
            260                 265                 270         


Glu Asn Arg Tyr Lys Lys Ile Arg Asp Arg Leu Tyr Ala Met Ala Lys 
        275                 280                 285             


Lys Leu Arg Gly Asp Lys Thr Lys Lys Ile Arg Leu Tyr His Glu Ile 
    290                 295                 300                 


Arg Lys Lys Phe Arg His Lys Val Lys Tyr Phe Arg Arg Asn Tyr Leu 
305                 310                 315                 320 


His Asn Ile Ser Lys Gln Ile Val Glu Ile Ala Lys Glu Asn Thr Pro 
                325                 330                 335     


Thr Val Ile Val Leu Glu Asp Leu Arg Tyr Leu Arg Glu Arg Thr Tyr 
            340                 345                 350         


Arg Gly Lys Gly Arg Ser Lys Lys Ala Lys Lys Thr Asn Tyr Lys Leu 
        355                 360                 365             


Asn Thr Phe Thr Tyr Arg Met Leu Ile Asp Met Ile Lys Tyr Lys Ala 
    370                 375                 380                 


Glu Glu Ala Gly Val Pro Val Met Ile Ile Asp Pro Arg Asn Thr Ser 
385                 390                 395                 400 


Arg Lys Cys Ser Lys Cys Gly Tyr Val Asp Glu Asn Asn Arg Lys Gln 
                405                 410                 415     


Ala Ser Phe Lys Cys Leu Lys Cys Gly Tyr Ser Leu Asn Ala Asp Leu 
            420                 425                 430         


Asn Ala Ala Val Asn Ile Ala Lys Ala Phe Tyr Glu Cys Pro Thr Phe 
        435                 440                 445             


Arg Trp Glu Glu Lys Leu His Ala Tyr Val Cys Ser Glu Pro Asp Lys 
    450                 455                 460                 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
465                 470                 475                 480 


Gly Ser Gly Gly Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser 
                485                 490                 495     


Leu Lys Leu Ile Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr 
            500                 505                 510         


Phe Ile Thr Phe Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val 
        515                 520                 525             


Asp Ile Arg Ser Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro 
    530                 535                 540                 


Ala Val Cys Asp Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn 
545                 550                 555                 560 


Ile Ser Asn Lys Thr Phe Lys Phe Lys Pro Ser Arg Asn Gln Lys Asp 
                565                 570                 575     


Arg Tyr Thr Lys Asp Ile Tyr Thr Ile Lys Pro Asn Ala His Ile Cys 
            580                 585                 590         


Lys Thr Cys Tyr Ser Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln 
        595                 600                 605             


Met Tyr Pro Asn Asp Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn 
    610                 615                 620                 


Ile Lys Val Asn Ala Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser 
625                 630                 635                 640 


Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
                645                 650 


<210> 276
<211> 650
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 276
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Gly Gly Ser Glu Lys Trp Gln Gly Ile Ser Leu Asn 
            20                  25                  30          


Lys Ala Lys Ser Lys Val Lys Asp Ile Glu Lys Arg Ile Lys Lys Leu 
        35                  40                  45              


Lys Glu Trp Lys His Pro Thr Leu Asn Arg Pro Tyr Val Glu Leu His 
    50                  55                  60                  


Lys Asn Asn Val Arg Ile Val Gly Tyr Glu Thr Val Glu Leu Lys Leu 
65                  70                  75                  80  


Gly Asn Lys Met Tyr Thr Ile His Phe Ala Ser Ile Ser Asn Leu Arg 
                85                  90                  95      


Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser Ile Glu Tyr Leu Lys His 
            100                 105                 110         


Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu Glu Thr Tyr Pro Ser Ile 
        115                 120                 125             


Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln Tyr Pro Val Arg Val Thr 
    130                 135                 140                 


Val Lys Val Pro Lys Leu Thr Lys Asn Phe Lys Ala Phe Gly Ile Asp 
145                 150                 155                 160 


Arg Gly Val Asn Arg Leu Ala Val Gly Cys Ile Ile Ser Lys Asp Gly 
                165                 170                 175     


Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe His Gly Lys Glu Ala Trp 
            180                 185                 190         


Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg Asp Arg Leu Tyr Ala Met 
        195                 200                 205             


Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys Lys Ile Arg Leu Tyr His 
    210                 215                 220                 


Glu Ile Arg Lys Lys Phe Arg His Lys Val Lys Tyr Phe Arg Arg Asn 
225                 230                 235                 240 


Tyr Leu His Asn Ile Ser Lys Gln Ile Val Glu Ile Ala Lys Glu Asn 
                245                 250                 255     


Thr Pro Thr Val Ile Val Leu Glu Asp Leu Arg Tyr Leu Arg Glu Arg 
            260                 265                 270         


Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys Ala Lys Lys Thr Asn Tyr 
        275                 280                 285             


Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu Ile Asp Met Ile Lys Tyr 
    290                 295                 300                 


Lys Ala Glu Glu Ala Gly Val Pro Val Met Ile Ile Asp Pro Arg Asn 
305                 310                 315                 320 


Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr Val Asp Glu Asn Asn Arg 
                325                 330                 335     


Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys Gly Tyr Ser Leu Asn Ala 
            340                 345                 350         


Asp Leu Asn Ala Ala Val Asn Ile Ala Lys Ala Phe Tyr Glu Cys Pro 
        355                 360                 365             


Thr Phe Arg Trp Glu Glu Lys Leu His Ala Tyr Val Cys Ser Glu Pro 
    370                 375                 380                 


Asp Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Ser Gly Gly Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr 
                405                 410                 415     


Leu Ser Leu Lys Leu Ile Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu 
            420                 425                 430         


Asn Tyr Phe Ile Thr Phe Gln Arg Ala Val Asn Phe Ala Ile Asp Arg 
        435                 440                 445             


Ile Val Asp Ile Arg Ser Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln 
    450                 455                 460                 


Phe Pro Ala Val Cys Asp Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr 
465                 470                 475                 480 


Val Asn Ile Ser Asn Lys Thr Phe Lys Phe Lys Pro Ser Arg Asn Gln 
                485                 490                 495     


Lys Asp Arg Tyr Thr Lys Asp Ile Tyr Thr Ile Lys Pro Asn Ala His 
            500                 505                 510         


Ile Cys Lys Thr Cys Tyr Ser Gly Val Ala Gly Asn Met Phe Ile Arg 
        515                 520                 525             


Lys Gln Met Tyr Pro Asn Asp Lys Glu Gly Trp Lys Val Ser Arg Ser 
    530                 535                 540                 


Tyr Asn Ile Lys Val Asn Ala Pro Gly Leu Thr Gly Thr Glu Tyr Ala 
545                 550                 555                 560 


Met Ala Ile Arg Lys Ala Ile Ser Ile Leu Arg Ser Phe Glu Lys Arg 
                565                 570                 575     


Arg Arg Asn Ala Glu Arg Arg Ile Ile Glu Tyr Glu Lys Ser Lys Lys 
            580                 585                 590         


Glu Tyr Leu Glu Leu Ile Asp Asp Val Glu Lys Gly Lys Thr Asn Lys 
        595                 600                 605             


Ile Val Val Leu Glu Lys Glu Gly His Gln Arg Val Lys Arg Tyr Lys 
    610                 615                 620                 


His Lys Asn Trp Pro Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser 
625                 630                 635                 640 


Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
                645                 650 


<210> 277
<211> 650
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 277
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Gly Gly Ser Asn Asn Val Arg Ile Val Gly Tyr Glu 
            20                  25                  30          


Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala 
        35                  40                  45              


Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser 
    50                  55                  60                  


Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu 
65                  70                  75                  80  


Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln 
                85                  90                  95      


Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe 
            100                 105                 110         


Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys 
        115                 120                 125             


Ile Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe 
    130                 135                 140                 


His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg 
145                 150                 155                 160 


Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys 
                165                 170                 175     


Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val 
            180                 185                 190         


Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val 
        195                 200                 205             


Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu 
    210                 215                 220                 


Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys 
225                 230                 235                 240 


Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu 
                245                 250                 255     


Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met 
            260                 265                 270         


Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr 
        275                 280                 285             


Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys 
    290                 295                 300                 


Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys 
305                 310                 315                 320 


Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala 
                325                 330                 335     


Tyr Val Cys Ser Glu Pro Asp Lys Gly Gly Ser Gly Gly Ser Gly Gly 
            340                 345                 350         


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Met Pro Ser Glu 
        355                 360                 365             


Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile Pro Ser Asp Glu 
    370                 375                 380                 


Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe Gln Arg Ala Val 
385                 390                 395                 400 


Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser Ser Phe Arg Tyr 
                405                 410                 415     


Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp Cys Cys Gly Lys 
            420                 425                 430         


Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys Thr Phe Lys Phe 
        435                 440                 445             


Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys Asp Ile Tyr Thr 
    450                 455                 460                 


Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr Ser Gly Val Ala 
465                 470                 475                 480 


Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn Asp Lys Glu Gly 
                485                 490                 495     


Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn Ala Pro Gly Leu 
            500                 505                 510         


Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile Ser Ile Leu 
        515                 520                 525             


Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg Ile Ile Glu 
    530                 535                 540                 


Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp Asp Val Glu 
545                 550                 555                 560 


Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu Gly His Gln 
                565                 570                 575     


Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu Lys Trp Gln Gly 
            580                 585                 590         


Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu Lys Arg 
        595                 600                 605             


Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg Pro Tyr 
    610                 615                 620                 


Val Glu Leu His Lys Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser 
625                 630                 635                 640 


Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
                645                 650 


<210> 278
<211> 650
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 278
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Gly Gly Ser Asp Gly Lys Leu Thr Asn Lys Asn Ile 
            20                  25                  30          


Phe Phe Phe His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys 
        35                  40                  45              


Lys Ile Arg Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp 
    50                  55                  60                  


Lys Thr Lys Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg 
65                  70                  75                  80  


His Lys Val Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys 
                85                  90                  95      


Gln Ile Val Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu 
            100                 105                 110         


Glu Asp Leu Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg 
        115                 120                 125             


Ser Lys Lys Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr 
    130                 135                 140                 


Arg Met Leu Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val 
145                 150                 155                 160 


Pro Val Met Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys 
                165                 170                 175     


Cys Gly Tyr Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys 
            180                 185                 190         


Leu Lys Cys Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn 
        195                 200                 205             


Ile Ala Lys Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys 
    210                 215                 220                 


Leu His Ala Tyr Val Cys Ser Glu Pro Asp Lys Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Met 
                245                 250                 255     


Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile Pro 
            260                 265                 270         


Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe Gln 
        275                 280                 285             


Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser Ser 
    290                 295                 300                 


Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp Cys 
305                 310                 315                 320 


Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys Thr 
                325                 330                 335     


Phe Lys Phe Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys Asp 
            340                 345                 350         


Ile Tyr Thr Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr Ser 
        355                 360                 365             


Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn Asp 
    370                 375                 380                 


Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn Ala 
385                 390                 395                 400 


Pro Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile 
                405                 410                 415     


Ser Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg 
            420                 425                 430         


Ile Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp 
        435                 440                 445             


Asp Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu 
    450                 455                 460                 


Gly His Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu Lys 
465                 470                 475                 480 


Trp Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile 
                485                 490                 495     


Glu Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn 
            500                 505                 510         


Arg Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr 
        515                 520                 525             


Glu Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe 
    530                 535                 540                 


Ala Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys 
545                 550                 555                 560 


Ser Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn 
                565                 570                 575     


Leu Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu 
            580                 585                 590         


Gln Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn 
        595                 600                 605             


Phe Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly 
    610                 615                 620                 


Cys Ile Ile Ser Lys Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser 
625                 630                 635                 640 


Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
                645                 650 


<210> 279
<211> 650
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 279
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Gly Gly Ser Lys Leu Thr Lys Asn Phe Lys Ala Phe 
            20                  25                  30          


Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys Ile Ile Ser 
        35                  40                  45              


Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe His Gly Lys 
    50                  55                  60                  


Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg Asp Arg Leu 
65                  70                  75                  80  


Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys Lys Ile Arg 
                85                  90                  95      


Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val Lys Tyr Phe 
            100                 105                 110         


Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val Glu Ile Ala 
        115                 120                 125             


Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu Arg Tyr Leu 
    130                 135                 140                 


Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys Ala Lys Lys 
145                 150                 155                 160 


Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu Ile Asp Met 
                165                 170                 175     


Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met Ile Ile Asp 
            180                 185                 190         


Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr Val Asp Glu 
        195                 200                 205             


Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu Lys Cys Gly Tyr Ser 
    210                 215                 220                 


Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala Lys Ala Phe Tyr 
225                 230                 235                 240 


Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His Ala Tyr Val Cys 
                245                 250                 255     


Ser Glu Pro Asp Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            260                 265                 270         


Ser Gly Gly Ser Gly Gly Ser Gly Gly Met Pro Ser Glu Thr Tyr Ile 
        275                 280                 285             


Thr Lys Thr Leu Ser Leu Lys Leu Ile Pro Ser Asp Glu Glu Lys Gln 
    290                 295                 300                 


Ala Leu Glu Asn Tyr Phe Ile Thr Phe Gln Arg Ala Val Asn Phe Ala 
305                 310                 315                 320 


Ile Asp Arg Ile Val Asp Ile Arg Ser Ser Phe Arg Tyr Leu Asn Lys 
                325                 330                 335     


Asn Glu Gln Phe Pro Ala Val Cys Asp Cys Cys Gly Lys Lys Glu Lys 
            340                 345                 350         


Ile Met Tyr Val Asn Ile Ser Asn Lys Thr Phe Lys Phe Lys Pro Ser 
        355                 360                 365             


Arg Asn Gln Lys Asp Arg Tyr Thr Lys Asp Ile Tyr Thr Ile Lys Pro 
    370                 375                 380                 


Asn Ala His Ile Cys Lys Thr Cys Tyr Ser Gly Val Ala Gly Asn Met 
385                 390                 395                 400 


Phe Ile Arg Lys Gln Met Tyr Pro Asn Asp Lys Glu Gly Trp Lys Val 
                405                 410                 415     


Ser Arg Ser Tyr Asn Ile Lys Val Asn Ala Pro Gly Leu Thr Gly Thr 
            420                 425                 430         


Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile Ser Ile Leu Arg Ser Phe 
        435                 440                 445             


Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg Ile Ile Glu Tyr Glu Lys 
    450                 455                 460                 


Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp Asp Val Glu Lys Gly Lys 
465                 470                 475                 480 


Thr Asn Lys Ile Val Val Leu Glu Lys Glu Gly His Gln Arg Val Lys 
                485                 490                 495     


Arg Tyr Lys His Lys Asn Trp Pro Glu Lys Trp Gln Gly Ile Ser Leu 
            500                 505                 510         


Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu Lys Arg Ile Lys Lys 
        515                 520                 525             


Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg Pro Tyr Val Glu Leu 
    530                 535                 540                 


His Lys Asn Asn Val Arg Ile Val Gly Tyr Glu Thr Val Glu Leu Lys 
545                 550                 555                 560 


Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala Ser Ile Ser Asn Leu 
                565                 570                 575     


Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser Ile Glu Tyr Leu Lys 
            580                 585                 590         


His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu Glu Thr Tyr Pro Ser 
        595                 600                 605             


Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln Tyr Pro Val Arg Val 
    610                 615                 620                 


Thr Val Lys Val Pro Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser 
625                 630                 635                 640 


Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
                645                 650 


<210> 280
<211> 650
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 280
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Gly Gly Ser Lys Asn Glu Gln Phe Pro Ala Val Cys 
            20                  25                  30          


Asp Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn 
        35                  40                  45              


Lys Thr Phe Lys Phe Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr 
    50                  55                  60                  


Lys Asp Ile Tyr Thr Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys 
65                  70                  75                  80  


Tyr Ser Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro 
                85                  90                  95      


Asn Asp Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val 
            100                 105                 110         


Asn Ala Pro Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys 
        115                 120                 125             


Ala Ile Ser Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu 
    130                 135                 140                 


Arg Arg Ile Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu 
145                 150                 155                 160 


Ile Asp Asp Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu 
                165                 170                 175     


Lys Glu Gly His Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro 
            180                 185                 190         


Glu Lys Trp Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys 
        195                 200                 205             


Asp Ile Glu Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr 
    210                 215                 220                 


Leu Asn Arg Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val 
225                 230                 235                 240 


Gly Tyr Glu Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile 
                245                 250                 255     


His Phe Ala Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys 
            260                 265                 270         


Lys Lys Ser Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys 
        275                 280                 285             


Arg Asn Leu Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe 
    290                 295                 300                 


Phe Leu Gln Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr 
305                 310                 315                 320 


Lys Asn Phe Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala 
                325                 330                 335     


Val Gly Cys Ile Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile 
            340                 345                 350         


Phe Phe Phe His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys 
        355                 360                 365             


Lys Ile Arg Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp 
    370                 375                 380                 


Lys Thr Lys Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg 
385                 390                 395                 400 


His Lys Val Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys 
                405                 410                 415     


Gln Ile Val Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu 
            420                 425                 430         


Glu Asp Leu Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg 
        435                 440                 445             


Ser Lys Lys Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr 
    450                 455                 460                 


Arg Met Leu Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val 
465                 470                 475                 480 


Pro Val Met Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys 
                485                 490                 495     


Cys Gly Tyr Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys 
            500                 505                 510         


Leu Lys Cys Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn 
        515                 520                 525             


Ile Ala Lys Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys 
    530                 535                 540                 


Leu His Ala Tyr Val Cys Ser Glu Pro Asp Lys Gly Gly Ser Gly Gly 
545                 550                 555                 560 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Met 
                565                 570                 575     


Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile Pro 
            580                 585                 590         


Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe Gln 
        595                 600                 605             


Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser Ser 
    610                 615                 620                 


Phe Arg Tyr Leu Asn Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser 
625                 630                 635                 640 


Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
                645                 650 


<210> 281
<211> 650
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 281
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Gly Gly Ser Lys Gln Ala Ser Phe Lys Cys Leu Lys 
            20                  25                  30          


Cys Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile Ala 
        35                  40                  45              


Lys Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu His 
    50                  55                  60                  


Ala Tyr Val Cys Ser Glu Pro Asp Lys Gly Gly Ser Gly Gly Ser Gly 
65                  70                  75                  80  


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Met Pro Ser 
                85                  90                  95      


Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile Pro Ser Asp 
            100                 105                 110         


Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe Gln Arg Ala 
        115                 120                 125             


Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser Ser Phe Arg 
    130                 135                 140                 


Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp Cys Cys Gly 
145                 150                 155                 160 


Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys Thr Phe Lys 
                165                 170                 175     


Phe Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys Asp Ile Tyr 
            180                 185                 190         


Thr Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr Ser Gly Val 
        195                 200                 205             


Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn Asp Lys Glu 
    210                 215                 220                 


Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn Ala Pro Gly 
225                 230                 235                 240 


Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile Ser Ile 
                245                 250                 255     


Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg Ile Ile 
            260                 265                 270         


Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp Asp Val 
        275                 280                 285             


Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu Gly His 
    290                 295                 300                 


Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu Lys Trp Gln 
305                 310                 315                 320 


Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu Lys 
                325                 330                 335     


Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg Pro 
            340                 345                 350         


Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr Glu Thr 
        355                 360                 365             


Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala Ser 
    370                 375                 380                 


Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser Ile 
385                 390                 395                 400 


Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu Glu 
                405                 410                 415     


Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln Tyr 
            420                 425                 430         


Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe Lys 
        435                 440                 445             


Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys Ile 
    450                 455                 460                 


Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe His 
465                 470                 475                 480 


Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg Asp 
                485                 490                 495     


Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys Lys 
            500                 505                 510         


Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val Lys 
        515                 520                 525             


Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val Glu 
    530                 535                 540                 


Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu Arg 
545                 550                 555                 560 


Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys Ala 
                565                 570                 575     


Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu Ile 
            580                 585                 590         


Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met Ile 
        595                 600                 605             


Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys Gly Tyr Val 
    610                 615                 620                 


Asp Glu Asn Asn Arg Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser 
625                 630                 635                 640 


Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
                645                 650 


<210> 282
<211> 650
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 282
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Gly Gly Ser Ala Met Ala Lys Lys Leu Arg Gly Asp 
            20                  25                  30          


Lys Thr Lys Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg 
        35                  40                  45              


His Lys Val Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys 
    50                  55                  60                  


Gln Ile Val Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu 
65                  70                  75                  80  


Glu Asp Leu Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg 
                85                  90                  95      


Ser Lys Lys Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr 
            100                 105                 110         


Arg Met Leu Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val 
        115                 120                 125             


Pro Val Met Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys 
    130                 135                 140                 


Cys Gly Tyr Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys 
145                 150                 155                 160 


Leu Lys Cys Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn 
                165                 170                 175     


Ile Ala Lys Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys 
            180                 185                 190         


Leu His Ala Tyr Val Cys Ser Glu Pro Asp Lys Gly Gly Ser Gly Gly 
        195                 200                 205             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Met 
    210                 215                 220                 


Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile Pro 
225                 230                 235                 240 


Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe Gln 
                245                 250                 255     


Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser Ser 
            260                 265                 270         


Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp Cys 
        275                 280                 285             


Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys Thr 
    290                 295                 300                 


Phe Lys Phe Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys Asp 
305                 310                 315                 320 


Ile Tyr Thr Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr Ser 
                325                 330                 335     


Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn Asp 
            340                 345                 350         


Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn Ala 
        355                 360                 365             


Pro Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile 
    370                 375                 380                 


Ser Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg 
385                 390                 395                 400 


Ile Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp 
                405                 410                 415     


Asp Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu 
            420                 425                 430         


Gly His Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu Lys 
        435                 440                 445             


Trp Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile 
    450                 455                 460                 


Glu Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn 
465                 470                 475                 480 


Arg Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr 
                485                 490                 495     


Glu Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe 
            500                 505                 510         


Ala Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys 
        515                 520                 525             


Ser Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn 
    530                 535                 540                 


Leu Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu 
545                 550                 555                 560 


Gln Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn 
                565                 570                 575     


Phe Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly 
            580                 585                 590         


Cys Ile Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe 
        595                 600                 605             


Phe His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile 
    610                 615                 620                 


Arg Asp Arg Leu Tyr Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser 
625                 630                 635                 640 


Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
                645                 650 


<210> 283
<211> 650
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 283
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Gly Gly Ser Arg Tyr Lys His Lys Asn Trp Pro Glu 
            20                  25                  30          


Lys Trp Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp 
        35                  40                  45              


Ile Glu Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu 
    50                  55                  60                  


Asn Arg Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly 
65                  70                  75                  80  


Tyr Glu Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His 
                85                  90                  95      


Phe Ala Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys 
            100                 105                 110         


Lys Ser Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg 
        115                 120                 125             


Asn Leu Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe 
    130                 135                 140                 


Leu Gln Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys 
145                 150                 155                 160 


Asn Phe Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val 
                165                 170                 175     


Gly Cys Ile Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe 
            180                 185                 190         


Phe Phe His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys 
        195                 200                 205             


Ile Arg Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys 
    210                 215                 220                 


Thr Lys Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His 
225                 230                 235                 240 


Lys Val Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln 
                245                 250                 255     


Ile Val Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu 
            260                 265                 270         


Asp Leu Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser 
        275                 280                 285             


Lys Lys Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg 
    290                 295                 300                 


Met Leu Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro 
305                 310                 315                 320 


Val Met Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys 
                325                 330                 335     


Gly Tyr Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu 
            340                 345                 350         


Lys Cys Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile 
        355                 360                 365             


Ala Lys Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu 
    370                 375                 380                 


His Ala Tyr Val Cys Ser Glu Pro Asp Lys Gly Gly Ser Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Met Pro 
                405                 410                 415     


Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile Pro Ser 
            420                 425                 430         


Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe Gln Arg 
        435                 440                 445             


Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser Ser Phe 
    450                 455                 460                 


Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp Cys Cys 
465                 470                 475                 480 


Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys Thr Phe 
                485                 490                 495     


Lys Phe Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys Asp Ile 
            500                 505                 510         


Tyr Thr Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr Ser Gly 
        515                 520                 525             


Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn Asp Lys 
    530                 535                 540                 


Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn Ala Pro 
545                 550                 555                 560 


Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile Ser 
                565                 570                 575     


Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg Ile 
            580                 585                 590         


Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp Asp 
        595                 600                 605             


Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu Gly 
    610                 615                 620                 


His Gln Arg Val Lys Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser 
625                 630                 635                 640 


Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
                645                 650 


<210> 284
<211> 650
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 284
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Gly Gly Ser Asn Thr Ser Arg Lys Cys Ser Lys Cys 
            20                  25                  30          


Gly Tyr Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu 
        35                  40                  45              


Lys Cys Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile 
    50                  55                  60                  


Ala Lys Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu 
65                  70                  75                  80  


His Ala Tyr Val Cys Ser Glu Pro Asp Lys Gly Gly Ser Gly Gly Ser 
                85                  90                  95      


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Met Pro 
            100                 105                 110         


Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile Pro Ser 
        115                 120                 125             


Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe Gln Arg 
    130                 135                 140                 


Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser Ser Phe 
145                 150                 155                 160 


Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp Cys Cys 
                165                 170                 175     


Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys Thr Phe 
            180                 185                 190         


Lys Phe Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys Asp Ile 
        195                 200                 205             


Tyr Thr Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr Ser Gly 
    210                 215                 220                 


Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn Asp Lys 
225                 230                 235                 240 


Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn Ala Pro 
                245                 250                 255     


Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala Ile Ser 
            260                 265                 270         


Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg Arg Ile 
        275                 280                 285             


Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile Asp Asp 
    290                 295                 300                 


Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys Glu Gly 
305                 310                 315                 320 


His Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu Lys Trp 
                325                 330                 335     


Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp Ile Glu 
            340                 345                 350         


Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu Asn Arg 
        355                 360                 365             


Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly Tyr Glu 
    370                 375                 380                 


Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His Phe Ala 
385                 390                 395                 400 


Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys Lys Ser 
                405                 410                 415     


Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg Asn Leu 
            420                 425                 430         


Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe Leu Gln 
        435                 440                 445             


Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys Asn Phe 
    450                 455                 460                 


Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val Gly Cys 
465                 470                 475                 480 


Ile Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe Phe Phe 
                485                 490                 495     


His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys Ile Arg 
            500                 505                 510         


Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys Thr Lys 
        515                 520                 525             


Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His Lys Val 
    530                 535                 540                 


Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln Ile Val 
545                 550                 555                 560 


Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu Asp Leu 
                565                 570                 575     


Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser Lys Lys 
            580                 585                 590         


Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg Met Leu 
        595                 600                 605             


Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro Val Met 
    610                 615                 620                 


Ile Ile Asp Pro Arg Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser 
625                 630                 635                 640 


Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
                645                 650 


<210> 285

<400> 285
000


<210> 286
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 286
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210> 287
<211> 155
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 287
gctccacttt aataagtggt gccttccaaa gctatatgct gagggaggat gggcgctgtt       60

gcagcgtctg cccacctgct cagacaggtg ggtatcctta cctattgaaa agtaataggt      120

caaggaatgc aactggttgc ccaccctagt cattg                                 155


<210> 288
<211> 155
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 288
gcaccacttt aataagtggt gccttccaaa gctgctatat gcagctgagg gaggatgggc       60

gctgcggcat gcgtctgccc acctcagagt gggtatcctt acctattaaa agtaataggt      120

caaggaatgc cgctggttgc ccaccctagt cattg                                 155


<210> 289
<211> 61
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (13)..(41)
<223> a, c, t, g, unknown or other

<400> 289
atggggagga cannnnnnnn nnnnnnnnnn nnnnnnnnnn ncaaacccac gagggcagag       60

t                                                                       61


<210> 290
<211> 67
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown:
      EMX1 sequence

<400> 290
atggggagga catcgatgtc acctccaatg actagggtgg gcaaccacaa acccacgagg       60

gcagagt                                                                 67


<210> 291
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 291
atggggagga catcgatgtc acaaacccac gagggcagag t                           41


<210> 292
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 292
atggggagga catcgatgtc acgtgggcaa ccacaaaccc acgagggcag agt              53


<210> 293
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 293
atggggagga catcgatgtc accacaaacc cacgagggca gagt                        44


<210> 294
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 294
atggggagga catcgatgtc acccacgagg gcagagt                                37


<210> 295
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 295
atggggagga catcgatgcc acaaacccac gagggcagag t                           41


<210> 296
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 296
atggggagga catcgatgtc acgagggcag agt                                    33


<210> 297
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 297
atggggagga catcgatgtg ggcaaccaca aacccacgag ggcagagt                    48


<210> 298
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 298
atggggagga ccacaaaccc acgagggcag agt                                    33


<210> 299
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 299
atggggagga catcgatgtc acggtgggca accacaaacc cacgagggca gagt             54


<210> 300
<211> 61
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 300
atggggagga catcgatgtc actgactagg gtgggcaacc acaaacccac gagggcagag       60

t                                                                       61


<210> 301
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 301
atggggagga catcgatgtc actgggcaac cacaaaccca cgagggcaga gt               52


<210> 302
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 302
atggggagga catcgatgtc actagggtgg gcaaccacaa acccacgagg gcagagt          57


<210> 303
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 303
atggggagga catcgtgggc aaccacaaac ccacgagggc agagt                       45


<210> 304
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 304
atggggagga catcgatgtc acgactaggg tgggcaacca caaacccacg agggcagagt       60


<210> 305
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 305
atggggagga cgtgggcaac cacaaaccca cgagggcaga gt                          42


<210> 306
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 306
atggggagga catcgatgtc acgggcaacc acaaacccac gagggcagag t                51


<210> 307
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 307
atggggagga cacaaaccca cgagggcaga gt                                     32


<210> 308
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 308
atggggagga catcgatggg caaccacaaa cccacgaggg cagagt                      46


<210> 309
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 309
atggggagga catcggtggg caaccacaaa cccacgaggg cagagt                      46


<210> 310
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 310
atggggagga catcgatgtc acactagggt gggcaaccac aaacccacga gggcagagt        59


<210> 311
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 311
atggggagga catcgatgtc acctagggtg ggcaaccaca aacccacgag ggcagagt         58


<210> 312
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 312
atggggagga caaacccacg agggcagagt                                        30


<210> 313
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 313
atggggagga catcgatgtc acccacaaac ccacgagggc agagt                       45


<210> 314
<211> 126
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 314
guccacuuua auaaguggug ccuuccaaag cuauaugcug agggaggaug ggcgcuguug       60

cagcgucucc ccaccucaga guggguaucc uuaccuauug aaaaguaaua ggucaaggaa      120

ugcaac                                                                 126


<210> 315
<211> 153
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (133)..(153)
<223> a, c, t, g, unknown or other

<400> 315
gctccacttg ctaatgcaag tggtgccttc caaagctata tgctgaggga ggatgggcgc       60

tgcggcatgc gtctgcccac ctcagagtgg gtatccttac ctattgaaaa gtaataggtc      120

aaggaatgcc gcnnnnnnnn nnnnnnnnnn nnn                                   153


<210> 316
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 316
Ala Pro Leu Ala Asn Ala Ser Gly Ala Phe Gln Ser Tyr Met Leu Arg 
1               5                   10                  15      


Glu Asp Gly Arg Cys Gly Met Arg Leu Pro Thr Ser Glu Trp Val Ser 
            20                  25                  30          


Leu Pro Ile Glu Lys 
        35          


<210> 317
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 317
tatgagttac aacgaacacc tc                                                22


<210> 318
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (6)..(12)
<223> Any amino acid

<400> 318
Val Lys Glu Cys Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10          


