                         SEQUENCE LISTING

<110>  BridgeBio Gene Therapy Research, Inc.
 
<120>  GENE THERAPY FOR TUBEROUS SCLEROSIS

<130>  BGTR-003/01WO 340389-2014

<150>  US 63/210,456
<151>  2021-06-14

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  1807
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
1               5                   10                  15      


Ile Leu Leu Gly Leu Gly Thr Pro Arg Pro Asn Pro Arg Ser Ala Glu 
            20                  25                  30          


Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
        35                  40                  45              


Ser Met Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
    50                  55                  60                  


Cys Glu Val Ala Lys Thr Lys Lys Phe Glu Glu His Ala Val Glu Ala 
65                  70                  75                  80  


Leu Trp Lys Ala Val Ala Asp Leu Leu Gln Pro Glu Arg Pro Leu Glu 
                85                  90                  95      


Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
            100                 105                 110         


Gly Glu Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
        115                 120                 125             


Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
    130                 135                 140                 


Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
145                 150                 155                 160 


Ala Asp Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                165                 170                 175     


Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
            180                 185                 190         


Glu Tyr Ile Ala Arg Met Val Gln Met Ile Cys Leu Leu Cys Val Arg 
        195                 200                 205             


Thr Ala Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
    210                 215                 220                 


Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
225                 230                 235                 240 


Val Thr Leu Cys Arg Thr Ile Asn Val Lys Glu Leu Cys Glu Pro Cys 
                245                 250                 255     


Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
            260                 265                 270         


Ile Tyr Asn Met Cys His Leu Met Glu Asp Arg Ala Tyr Met Glu Asp 
        275                 280                 285             


Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
    290                 295                 300                 


Gly Ala His Arg Leu Tyr Ser Leu Arg Asn Ser Pro Thr Ser Val Leu 
305                 310                 315                 320 


Pro Ser Phe Tyr Gln Ala Met Ala Cys Pro Asn Glu Val Val Ser Tyr 
                325                 330                 335     


Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
            340                 345                 350         


Leu Gln Val Val Ala Trp Asp Ile Leu Leu Asn Ile Ile Glu Arg Leu 
        355                 360                 365             


Leu Gln Gln Leu Gln Thr Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
    370                 375                 380                 


His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
385                 390                 395                 400 


His Gly Ser Gln Glu Arg Tyr Phe Glu Leu Val Glu Arg Cys Ala Asp 
                405                 410                 415     


Gln Arg Pro Glu Ser Ser Leu Leu Asn Leu Ile Ser Tyr Arg Ala Gln 
            420                 425                 430         


Ser Ile His Pro Ala Lys Asp Gly Trp Ile Gln Asn Leu Gln Ala Leu 
        435                 440                 445             


Met Glu Arg Phe Phe Arg Ser Glu Ser Arg Gly Ala Val Arg Ile Lys 
    450                 455                 460                 


Val Leu Asp Val Leu Ser Phe Val Leu Leu Ile Asn Arg Gln Phe Tyr 
465                 470                 475                 480 


Glu Glu Glu Leu Ile Asn Ser Val Val Ile Ser Gln Leu Ser His Ile 
                485                 490                 495     


Pro Glu Asp Lys Asp His Gln Val Arg Lys Leu Ala Thr Gln Leu Leu 
            500                 505                 510         


Val Asp Leu Ala Glu Gly Cys His Thr His His Phe Asn Ser Leu Leu 
        515                 520                 525             


Asp Ile Ile Glu Lys Val Met Ala Arg Ser Leu Ser Pro Pro Pro Glu 
    530                 535                 540                 


Leu Glu Glu Arg Asp Val Ala Ala Tyr Ser Ala Ser Leu Glu Asp Val 
545                 550                 555                 560 


Lys Thr Ala Val Leu Gly Leu Leu Val Ile Leu Gln Thr Lys Leu Tyr 
                565                 570                 575     


Thr Leu Pro Ala Ser His Ala Thr Arg Val Tyr Glu Met Leu Val Ser 
            580                 585                 590         


His Ile Gln Leu His Tyr Lys His Ser Tyr Thr Leu Pro Ile Ala Ser 
        595                 600                 605             


Ser Ile Arg Leu Gln Ala Phe Asp Phe Leu Leu Leu Leu Arg Ala Asp 
    610                 615                 620                 


Ser Leu His Arg Leu Gly Leu Pro Asn Lys Asp Gly Val Val Arg Phe 
625                 630                 635                 640 


Ser Pro Tyr Cys Val Cys Asp Tyr Met Glu Pro Glu Arg Gly Ser Glu 
                645                 650                 655     


Lys Lys Thr Ser Gly Pro Leu Ser Pro Pro Thr Gly Pro Pro Gly Pro 
            660                 665                 670         


Ala Pro Ala Gly Pro Ala Val Arg Leu Gly Ser Val Pro Tyr Ser Leu 
        675                 680                 685             


Leu Phe Arg Val Leu Leu Gln Cys Leu Lys Gln Glu Ser Asp Trp Lys 
    690                 695                 700                 


Val Leu Lys Leu Val Leu Gly Arg Leu Pro Glu Ser Leu Arg Tyr Lys 
705                 710                 715                 720 


Val Leu Ile Phe Thr Ser Pro Cys Ser Val Asp Gln Leu Cys Ser Ala 
                725                 730                 735     


Leu Cys Ser Met Leu Ser Gly Pro Lys Thr Leu Glu Arg Leu Arg Gly 
            740                 745                 750         


Ala Pro Glu Gly Phe Ser Arg Thr Asp Leu His Leu Ala Val Val Pro 
        755                 760                 765             


Val Leu Thr Ala Leu Ile Ser Tyr His Asn Tyr Leu Asp Lys Thr Lys 
    770                 775                 780                 


Gln Arg Glu Met Val Tyr Cys Leu Glu Gln Gly Leu Ile His Arg Cys 
785                 790                 795                 800 


Ala Ser Gln Cys Val Val Ala Leu Ser Ile Cys Ser Val Glu Met Pro 
                805                 810                 815     


Asp Ile Ile Ile Lys Ala Leu Pro Val Leu Val Val Lys Leu Thr His 
            820                 825                 830         


Ile Ser Ala Thr Ala Ser Met Ala Val Pro Leu Leu Glu Phe Leu Ser 
        835                 840                 845             


Thr Leu Ala Arg Leu Pro His Leu Tyr Arg Asn Phe Ala Ala Glu Gln 
    850                 855                 860                 


Tyr Ala Ser Val Phe Ala Ile Ser Leu Pro Tyr Thr Asn Pro Ser Lys 
865                 870                 875                 880 


Phe Asn Gln Tyr Ile Val Cys Leu Ala His His Val Ile Ala Met Trp 
                885                 890                 895     


Phe Ile Arg Cys Arg Leu Pro Phe Arg Lys Asp Phe Val Pro Phe Ile 
            900                 905                 910         


Thr Lys Gly Leu Arg Ser Asn Val Leu Leu Ser Phe Asp Asp Thr Pro 
        915                 920                 925             


Glu Lys Asp Ser Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro 
    930                 935                 940                 


Lys Ser Leu Arg Ile Ala Arg Pro Pro Lys Gln Gly Leu Asn Asn Ser 
945                 950                 955                 960 


Pro Pro Val Lys Glu Phe Lys Glu Ser Ser Ala Ala Glu Ala Phe Arg 
                965                 970                 975     


Cys Arg Ser Ile Ser Val Ser Glu His Val Val Arg Ser Arg Ile Gln 
            980                 985                 990         


Thr Ser Leu Thr Ser Ala Ser Leu  Gly Ser Ala Asp Glu  Asn Ser Val 
        995                 1000                 1005             


Ala Gln  Ala Asp Asp Ser Leu  Lys Asn Leu His Leu  Glu Leu Thr 
    1010                 1015                 1020             


Glu Thr  Cys Leu Asp Met Met  Ala Arg Tyr Val Phe  Ser Asn Phe 
    1025                 1030                 1035             


Thr Ala  Val Pro Lys Arg Ser  Pro Val Gly Glu Phe  Leu Leu Ala 
    1040                 1045                 1050             


Gly Gly  Arg Thr Lys Thr Trp  Leu Val Gly Asn Lys  Leu Val Thr 
    1055                 1060                 1065             


Val Thr  Thr Ser Val Gly Thr  Gly Thr Arg Ser Leu  Leu Gly Leu 
    1070                 1075                 1080             


Asp Ser  Gly Glu Leu Gln Ser  Gly Pro Glu Ser Ser  Ser Ser Pro 
    1085                 1090                 1095             


Gly Val  His Val Arg Gln Thr  Lys Glu Ala Pro Ala  Lys Leu Glu 
    1100                 1105                 1110             


Ser Gln  Ala Gly Gln Gln Val  Ser Arg Gly Ala Arg  Asp Arg Val 
    1115                 1120                 1125             


Arg Ser  Met Ser Gly Gly His  Gly Leu Arg Val Gly  Ala Leu Asp 
    1130                 1135                 1140             


Val Pro  Ala Ser Gln Phe Leu  Gly Ser Ala Thr Ser  Pro Gly Pro 
    1145                 1150                 1155             


Arg Thr  Ala Pro Ala Ala Lys  Pro Glu Lys Ala Ser  Ala Gly Thr 
    1160                 1165                 1170             


Arg Val  Pro Val Gln Glu Lys  Thr Asn Leu Ala Ala  Tyr Val Pro 
    1175                 1180                 1185             


Leu Leu  Thr Gln Gly Trp Ala  Glu Ile Leu Val Arg  Arg Pro Thr 
    1190                 1195                 1200             


Gly Asn  Thr Ser Trp Leu Met  Ser Leu Glu Asn Pro  Leu Ser Pro 
    1205                 1210                 1215             


Phe Ser  Ser Asp Ile Asn Asn  Met Pro Leu Gln Glu  Leu Ser Asn 
    1220                 1225                 1230             


Ala Leu  Met Ala Ala Glu Arg  Phe Lys Glu His Arg  Asp Thr Ala 
    1235                 1240                 1245             


Leu Tyr  Lys Ser Leu Ser Val  Pro Ala Ala Ser Thr  Ala Lys Pro 
    1250                 1255                 1260             


Pro Pro  Leu Pro Arg Ser Asn  Thr Val Ala Ser Phe  Ser Ser Leu 
    1265                 1270                 1275             


Tyr Gln  Ser Ser Cys Gln Gly  Gln Leu His Arg Ser  Val Ser Trp 
    1280                 1285                 1290             


Ala Asp  Ser Ala Val Val Met  Glu Glu Gly Ser Pro  Gly Glu Val 
    1295                 1300                 1305             


Pro Val  Leu Val Glu Pro Pro  Gly Leu Glu Asp Val  Glu Ala Ala 
    1310                 1315                 1320             


Leu Gly  Met Asp Arg Arg Thr  Asp Ala Tyr Ser Arg  Ser Ser Ser 
    1325                 1330                 1335             


Val Ser  Ser Gln Glu Glu Lys  Ser Leu His Ala Glu  Glu Leu Val 
    1340                 1345                 1350             


Gly Arg  Gly Ile Pro Ile Glu  Arg Val Val Ser Ser  Glu Gly Gly 
    1355                 1360                 1365             


Arg Pro  Ser Val Asp Leu Ser  Phe Gln Pro Ser Gln  Pro Leu Ser 
    1370                 1375                 1380             


Lys Ser  Ser Ser Ser Pro Glu  Leu Gln Thr Leu Gln  Asp Ile Leu 
    1385                 1390                 1395             


Gly Asp  Pro Gly Asp Lys Ala  Asp Val Gly Arg Leu  Ser Pro Glu 
    1400                 1405                 1410             


Val Lys  Ala Arg Ser Gln Ser  Gly Thr Leu Asp Gly  Glu Ser Ala 
    1415                 1420                 1425             


Ala Trp  Ser Ala Ser Gly Glu  Asp Ser Arg Gly Gln  Pro Glu Gly 
    1430                 1435                 1440             


Pro Leu  Pro Ser Ser Ser Pro  Arg Ser Pro Ser Gly  Leu Arg Pro 
    1445                 1450                 1455             


Arg Gly  Tyr Thr Ile Ser Asp  Ser Ala Pro Ser Arg  Arg Gly Lys 
    1460                 1465                 1470             


Arg Val  Glu Arg Asp Ala Leu  Lys Ser Arg Ala Thr  Ala Ser Asn 
    1475                 1480                 1485             


Ala Glu  Lys Val Pro Gly Ile  Asn Pro Ser Phe Val  Phe Leu Gln 
    1490                 1495                 1500             


Leu Tyr  His Ser Pro Phe Phe  Gly Asp Glu Ser Asn  Lys Pro Ile 
    1505                 1510                 1515             


Leu Leu  Pro Asn Glu Ser Gln  Ser Phe Glu Arg Ser  Val Gln Leu 
    1520                 1525                 1530             


Leu Asp  Gln Ile Pro Ser Tyr  Asp Thr His Lys Ile  Ala Val Leu 
    1535                 1540                 1545             


Tyr Val  Gly Glu Gly Gln Ser  Asn Ser Glu Leu Ala  Ile Leu Ser 
    1550                 1555                 1560             


Asn Glu  His Gly Ser Tyr Arg  Tyr Thr Glu Phe Leu  Thr Gly Leu 
    1565                 1570                 1575             


Gly Arg  Leu Ile Glu Leu Lys  Asp Cys Gln Pro Asp  Lys Val Tyr 
    1580                 1585                 1590             


Leu Gly  Gly Leu Asp Val Cys  Gly Glu Asp Gly Gln  Phe Thr Tyr 
    1595                 1600                 1605             


Cys Trp  His Asp Asp Ile Met  Gln Ala Val Phe His  Ile Ala Thr 
    1610                 1615                 1620             


Leu Met  Pro Thr Lys Asp Val  Asp Lys His Arg Cys  Asp Lys Lys 
    1625                 1630                 1635             


Arg His  Leu Gly Asn Asp Phe  Val Ser Ile Val Tyr  Asn Asp Ser 
    1640                 1645                 1650             


Gly Glu  Asp Phe Lys Leu Gly  Thr Ile Lys Gly Gln  Phe Asn Phe 
    1655                 1660                 1665             


Val His  Val Ile Val Thr Pro  Leu Asp Tyr Glu Cys  Asn Leu Val 
    1670                 1675                 1680             


Ser Leu  Gln Cys Arg Lys Asp  Met Glu Gly Leu Val  Asp Thr Ser 
    1685                 1690                 1695             


Val Ala  Lys Ile Val Ser Asp  Arg Asn Leu Pro Phe  Val Ala Arg 
    1700                 1705                 1710             


Gln Met  Ala Leu His Ala Asn  Met Ala Ser Gln Val  His His Ser 
    1715                 1720                 1725             


Arg Ser  Asn Pro Thr Asp Ile  Tyr Pro Ser Lys Trp  Ile Ala Arg 
    1730                 1735                 1740             


Leu Arg  His Ile Lys Arg Leu  Arg Gln Arg Ile Cys  Glu Glu Ala 
    1745                 1750                 1755             


Ala Tyr  Ser Asn Pro Ser Leu  Pro Leu Val His Pro  Pro Ser His 
    1760                 1765                 1770             


Ser Lys  Ala Pro Ala Gln Thr  Pro Ala Glu Pro Thr  Pro Gly Tyr 
    1775                 1780                 1785             


Glu Val  Gly Gln Arg Lys Arg  Leu Ile Ser Ser Val  Glu Asp Phe 
    1790                 1795                 1800             


Thr Glu  Phe Val 
    1805         


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide spacer

<400>  2

Ser Gly Gly Gly 
1               


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide spacer

<400>  3

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


<210>  4
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
1               5                   10                  15      


Ile Leu Leu Gly Leu Gly Thr Pro Arg Pro Asn Pro Arg Ser Ala Glu 
            20                  25                  30          


Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
        35                  40                  45              


Ser Met Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
    50                  55                  60                  


Cys Glu Val Ala Lys Thr Lys Lys Phe Glu Glu His Ala Val Glu Ala 
65                  70                  75                  80  


Leu Trp Lys Ala Val Ala Asp Leu Leu Gln Pro Glu Arg Pro Leu Glu 
                85                  90                  95      


Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
            100                 105                 110         


Gly Glu Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
        115                 120                 125             


Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
    130                 135                 140                 


Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
145                 150                 155                 160 


Ala Asp Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                165                 170                 175     


Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
            180                 185                 190         


Glu Tyr Ile Ala Arg Met Val Gln Met Ile Cys Leu Leu Cys Val Arg 
        195                 200                 205             


Thr Ala Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
    210                 215                 220                 


Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
225                 230                 235                 240 


Val Thr Leu Cys Arg Thr Ile Asn Val Lys Glu Leu Cys Glu Pro Cys 
                245                 250                 255     


Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
            260                 265                 270         


Ile Tyr Asn Met Cys His Leu Met Glu Asp Arg Ala Tyr Met Glu Asp 
        275                 280                 285             


Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
    290                 295                 300                 


Gly Ala His Arg Leu Tyr Ser Leu Arg Asn Ser Pro Thr Ser Val Leu 
305                 310                 315                 320 


Pro Ser Phe Tyr Gln Ala Met Ala Cys Pro Asn Glu Val Val Ser Tyr 
                325                 330                 335     


Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
            340                 345                 350         


Leu Gln Val Val Ala Trp Asp Ile Leu Leu Asn Ile Ile Glu Arg Leu 
        355                 360                 365             


Leu Gln Gln Leu Gln Thr Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
    370                 375                 380                 


His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
385                 390                 395                 400 


His Gly Ser Gln Glu Arg Tyr Phe Glu Leu Val Glu Arg Cys Ala Asp 
                405                 410                 415     


Gln Arg Pro Glu Ser Ser Leu Leu Asn Leu Ile Ser Tyr Arg Ala Gln 
            420                 425                 430         


Ser Ile His Pro Ala Lys Asp Gly Trp Ile Gln Asn Leu Gln Ala Leu 
        435                 440                 445             


Met Glu 
    450 


<210>  5
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
1               5                   10                  15      


Ile Leu Leu Gly Leu Gly Thr Pro Arg Pro Asn Pro Arg Ser Ala Glu 
            20                  25                  30          


Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
        35                  40                  45              


Ser Met Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
    50                  55                  60                  


Cys Glu Val Ala Lys Thr Lys Lys Phe Glu Glu His Ala Val Glu Ala 
65                  70                  75                  80  


Leu Trp Lys Ala Val Ala Asp Leu Leu Gln Pro Glu Arg Pro Leu Glu 
                85                  90                  95      


Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
            100                 105                 110         


Gly Glu Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
        115                 120                 125             


Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
    130                 135                 140                 


Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
145                 150                 155                 160 


Ala Asp Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                165                 170                 175     


Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
            180                 185                 190         


Glu Tyr Ile Ala Arg Met Val Gln Met Ile Cys Leu Leu Cys Val Arg 
        195                 200                 205             


Thr Ala Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
    210                 215                 220                 


Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
225                 230                 235                 240 


Val Thr Leu Cys Arg Thr Ile Asn Val Lys Glu Leu Cys Glu Pro Cys 
                245                 250                 255     


Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
            260                 265                 270         


Ile Tyr Asn Met Cys His Leu Met Glu Asp Arg Ala Tyr Met Glu Asp 
        275                 280                 285             


Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
    290                 295                 300                 


Gly Ala His Arg Leu Tyr Ser Leu Arg Asn Ser Pro Thr Ser Val Leu 
305                 310                 315                 320 


Pro Ser Phe Tyr Gln Ala Met Ala Cys Pro Asn Glu Val Val Ser Tyr 
                325                 330                 335     


Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
            340                 345                 350         


Leu Gln Val Val Ala Trp Asp Ile Leu Leu Asn Ile Ile Glu Arg Leu 
        355                 360                 365             


Leu Gln Gln Leu Gln Thr Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
    370                 375                 380                 


His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
385                 390                 395                 400 


His Gly Ser Gln Glu Arg Tyr Phe Glu Leu Val Glu Arg Cys Ala Asp 
                405                 410                 415     


Gln Arg 
        


<210>  6
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  6

Lys Pro Ile Leu Leu Pro Asn Glu Ser Gln Ser Phe Glu Arg Ser Val 
1               5                   10                  15      


Gln Leu Leu Asp Gln Ile Pro Ser Tyr Asp Thr His Lys Ile Ala Val 
            20                  25                  30          


Leu Tyr Val Gly Glu Gly Gln Ser Asn Ser Glu Leu Ala Ile Leu Ser 
        35                  40                  45              


Asn Glu His Gly Ser Tyr Arg Tyr Thr Glu Phe Leu Thr Gly Leu Gly 
    50                  55                  60                  


Arg Leu Ile Glu Leu Lys Asp Cys Gln Pro Asp Lys Val Tyr Leu Gly 
65                  70                  75                  80  


Gly Leu Asp Val Cys Gly Glu Asp Gly Gln Phe Thr Tyr Cys Trp His 
                85                  90                  95      


Asp Asp Ile Met Gln Ala Val Phe His Ile Ala Thr Leu Met Pro Thr 
            100                 105                 110         


Lys Asp Val Asp Lys His Arg Cys Asp Lys Lys Arg His Leu Gly Asn 
        115                 120                 125             


Asp Phe Val Ser Ile Val Tyr Asn Asp Ser Gly Glu Asp Phe Lys Leu 
    130                 135                 140                 


Gly Thr Ile Lys Gly Gln Phe Asn Phe Val His Val Ile Val Thr Pro 
145                 150                 155                 160 


Leu Asp Tyr Glu Cys Asn Leu Val Ser Leu Gln Cys Arg Lys Asp Met 
                165                 170                 175     


Glu Gly Leu Val Asp Thr Ser Val Ala Lys Ile Val Ser Asp Arg Asn 
            180                 185                 190         


Leu Pro Phe Val Ala Arg Gln Met Ala Leu His Ala Asn Met Ala Ser 
        195                 200                 205             


Gln Val His His Ser Arg Ser Asn Pro Thr Asp Ile Tyr Pro Ser Lys 
    210                 215                 220                 


Trp Ile Ala Arg Leu Arg His Ile Lys Arg Leu Arg Gln Arg Ile Cys 
225                 230                 235                 240 


Glu Glu Ala Ala Tyr Ser Asn Pro Ser Leu Pro Leu Val His Pro Pro 
                245                 250                 255     


Ser His Ser Lys Ala Pro Ala Gln Thr Pro Ala Glu Pro Thr Pro Gly 
            260                 265                 270         


Tyr Glu Val Gly Gln Arg Lys Arg Leu Ile Ser Ser Val Glu Asp Phe 
        275                 280                 285             


Thr Glu Phe Val 
    290         


<210>  7
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Ala Leu Asp Val Pro Ala Ser Gln Phe Leu Gly Ser Ala Thr Ser 
1               5                   10                  15      


Pro Gly Pro Arg Thr Ala Pro Ala Ala Lys Pro Glu Lys Ala Ser Ala 
            20                  25                  30          


Gly Thr Arg Val Pro Val Gln Glu Lys Thr Asn Leu Ala Ala Tyr Val 
        35                  40                  45              


Pro Leu Leu Thr Gln Gly Trp Ala Glu Ile Leu Val Arg Arg Pro Thr 
    50                  55                  60                  


Gly Asn Thr Ser Trp Leu Met Ser Leu Glu Asn Pro Leu Ser Pro Phe 
65                  70                  75                  80  


Ser Ser Asp Ile Asn Asn Met Pro Leu Gln Glu Leu Ser Asn Ala Leu 
                85                  90                  95      


Met Ala Ala Glu Arg Phe Lys Glu His Arg Asp Thr Ala Leu Tyr Lys 
            100                 105                 110         


Ser Leu Ser Val Pro Ala Ala Ser Thr Ala Lys Pro Pro Pro Leu Pro 
        115                 120                 125             


Arg Ser Asn Thr Val Ala Ser Phe Ser Ser Leu Tyr Gln Ser Ser Cys 
    130                 135                 140                 


Gln Gly Gln Leu His Arg Ser Val Ser Trp Ala Asp Ser Ala Val Val 
145                 150                 155                 160 


Met Glu Glu Gly Ser Pro Gly Glu Val Pro Val Leu Val Glu Pro Pro 
                165                 170                 175     


Gly Leu Glu Asp Val Glu Ala Ala Leu Gly Met Asp Arg Arg Thr Asp 
            180                 185                 190         


Ala Tyr Ser Arg Ser Ser Ser Val Ser Ser Gln Glu Glu Lys Ser Leu 
        195                 200                 205             


His Ala Glu Glu Leu Val Gly Arg Gly Ile Pro Ile Glu Arg Val Val 
    210                 215                 220                 


Ser Ser Glu Gly Gly Arg Pro Ser Val Asp Leu Ser Phe Gln Pro Ser 
225                 230                 235                 240 


Gln Pro Leu Ser Lys Ser Ser Ser Ser Pro Glu Leu Gln Thr Leu Gln 
                245                 250                 255     


Asp Ile Leu Gly Asp Pro Gly Asp Lys Ala Asp Val Gly Arg Leu Ser 
            260                 265                 270         


Pro Glu Val Lys Ala Arg Ser Gln Ser Gly Thr Leu Asp Gly Glu Ser 
        275                 280                 285             


Ala Ala Trp Ser Ala Ser Gly Glu Asp Ser Arg Gly Gln Pro Glu Gly 
    290                 295                 300                 


Pro Leu Pro Ser Ser Ser Pro Arg Ser Pro Ser Gly Leu Arg Pro Arg 
305                 310                 315                 320 


Gly Tyr Thr Ile Ser Asp Ser Ala Pro Ser Arg Arg Gly Lys Arg Val 
                325                 330                 335     


Glu Arg Asp Ala Leu Lys Ser Arg Ala Thr Ala Ser Asn Ala Glu Lys 
            340                 345                 350         


Val Pro Gly Ile Asn Pro Ser Phe Val Phe Leu Gln Leu Tyr His Ser 
        355                 360                 365             


Pro Phe Phe Gly Asp Glu Ser Asn Lys Pro Ile Leu Leu Pro Asn Glu 
    370                 375                 380                 


Ser Gln Ser Phe Glu Arg Ser Val Gln Leu Leu Asp Gln Ile Pro Ser 
385                 390                 395                 400 


Tyr Asp Thr His Lys Ile Ala Val Leu Tyr Val Gly Glu Gly Gln Ser 
                405                 410                 415     


Asn Ser Glu Leu Ala Ile Leu Ser Asn Glu His Gly Ser Tyr Arg Tyr 
            420                 425                 430         


Thr Glu Phe Leu Thr Gly Leu Gly Arg Leu Ile Glu Leu Lys Asp Cys 
        435                 440                 445             


Gln Pro Asp Lys Val Tyr Leu Gly Gly Leu Asp Val Cys Gly Glu Asp 
    450                 455                 460                 


Gly Gln Phe Thr Tyr Cys Trp His Asp Asp Ile Met Gln Ala Val Phe 
465                 470                 475                 480 


His Ile Ala Thr Leu Met Pro Thr Lys Asp Val Asp Lys His Arg Cys 
                485                 490                 495     


Asp Lys Lys Arg His Leu Gly Asn Asp Phe Val Ser Ile Val Tyr Asn 
            500                 505                 510         


Asp Ser Gly Glu Asp Phe Lys Leu Gly Thr Ile Lys Gly Gln Phe Asn 
        515                 520                 525             


Phe Val His Val Ile Val Thr Pro Leu Asp Tyr Glu Cys Asn Leu Val 
    530                 535                 540                 


Ser Leu Gln Cys Arg Lys Asp Met Glu Gly Leu Val Asp Thr Ser Val 
545                 550                 555                 560 


Ala Lys Ile Val Ser Asp Arg Asn Leu Pro Phe Val Ala Arg Gln Met 
                565                 570                 575     


Ala Leu His Ala Asn Met Ala Ser Gln Val His His Ser Arg Ser Asn 
            580                 585                 590         


Pro Thr Asp Ile Tyr Pro Ser Lys Trp Ile Ala Arg Leu Arg His Ile 
        595                 600                 605             


Lys Arg Leu Arg Gln Arg Ile Cys Glu Glu Ala Ala Tyr Ser Asn Pro 
    610                 615                 620                 


Ser Leu Pro Leu Val His Pro Pro Ser His Ser Lys Ala Pro Ala Gln 
625                 630                 635                 640 


Thr Pro Ala Glu Pro Thr Pro Gly Tyr Glu Val Gly Gln Arg Lys Arg 
                645                 650                 655     


Leu Ile Ser Ser Val Glu Asp Phe Thr Glu Phe Val 
            660                 665             


<210>  8
<211>  698
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Lys Leu Glu Ser Gln Ala Gly Gln Gln Val Ser Arg Gly Ala Arg 
1               5                   10                  15      


Asp Arg Val Arg Ser Met Ser Gly Gly His Gly Leu Arg Val Gly Ala 
            20                  25                  30          


Leu Asp Val Pro Ala Ser Gln Phe Leu Gly Ser Ala Thr Ser Pro Gly 
        35                  40                  45              


Pro Arg Thr Ala Pro Ala Ala Lys Pro Glu Lys Ala Ser Ala Gly Thr 
    50                  55                  60                  


Arg Val Pro Val Gln Glu Lys Thr Asn Leu Ala Ala Tyr Val Pro Leu 
65                  70                  75                  80  


Leu Thr Gln Gly Trp Ala Glu Ile Leu Val Arg Arg Pro Thr Gly Asn 
                85                  90                  95      


Thr Ser Trp Leu Met Ser Leu Glu Asn Pro Leu Ser Pro Phe Ser Ser 
            100                 105                 110         


Asp Ile Asn Asn Met Pro Leu Gln Glu Leu Ser Asn Ala Leu Met Ala 
        115                 120                 125             


Ala Glu Arg Phe Lys Glu His Arg Asp Thr Ala Leu Tyr Lys Ser Leu 
    130                 135                 140                 


Ser Val Pro Ala Ala Ser Thr Ala Lys Pro Pro Pro Leu Pro Arg Ser 
145                 150                 155                 160 


Asn Thr Val Ala Ser Phe Ser Ser Leu Tyr Gln Ser Ser Cys Gln Gly 
                165                 170                 175     


Gln Leu His Arg Ser Val Ser Trp Ala Asp Ser Ala Val Val Met Glu 
            180                 185                 190         


Glu Gly Ser Pro Gly Glu Val Pro Val Leu Val Glu Pro Pro Gly Leu 
        195                 200                 205             


Glu Asp Val Glu Ala Ala Leu Gly Met Asp Arg Arg Thr Asp Ala Tyr 
    210                 215                 220                 


Ser Arg Ser Ser Ser Val Ser Ser Gln Glu Glu Lys Ser Leu His Ala 
225                 230                 235                 240 


Glu Glu Leu Val Gly Arg Gly Ile Pro Ile Glu Arg Val Val Ser Ser 
                245                 250                 255     


Glu Gly Gly Arg Pro Ser Val Asp Leu Ser Phe Gln Pro Ser Gln Pro 
            260                 265                 270         


Leu Ser Lys Ser Ser Ser Ser Pro Glu Leu Gln Thr Leu Gln Asp Ile 
        275                 280                 285             


Leu Gly Asp Pro Gly Asp Lys Ala Asp Val Gly Arg Leu Ser Pro Glu 
    290                 295                 300                 


Val Lys Ala Arg Ser Gln Ser Gly Thr Leu Asp Gly Glu Ser Ala Ala 
305                 310                 315                 320 


Trp Ser Ala Ser Gly Glu Asp Ser Arg Gly Gln Pro Glu Gly Pro Leu 
                325                 330                 335     


Pro Ser Ser Ser Pro Arg Ser Pro Ser Gly Leu Arg Pro Arg Gly Tyr 
            340                 345                 350         


Thr Ile Ser Asp Ser Ala Pro Ser Arg Arg Gly Lys Arg Val Glu Arg 
        355                 360                 365             


Asp Ala Leu Lys Ser Arg Ala Thr Ala Ser Asn Ala Glu Lys Val Pro 
    370                 375                 380                 


Gly Ile Asn Pro Ser Phe Val Phe Leu Gln Leu Tyr His Ser Pro Phe 
385                 390                 395                 400 


Phe Gly Asp Glu Ser Asn Lys Pro Ile Leu Leu Pro Asn Glu Ser Gln 
                405                 410                 415     


Ser Phe Glu Arg Ser Val Gln Leu Leu Asp Gln Ile Pro Ser Tyr Asp 
            420                 425                 430         


Thr His Lys Ile Ala Val Leu Tyr Val Gly Glu Gly Gln Ser Asn Ser 
        435                 440                 445             


Glu Leu Ala Ile Leu Ser Asn Glu His Gly Ser Tyr Arg Tyr Thr Glu 
    450                 455                 460                 


Phe Leu Thr Gly Leu Gly Arg Leu Ile Glu Leu Lys Asp Cys Gln Pro 
465                 470                 475                 480 


Asp Lys Val Tyr Leu Gly Gly Leu Asp Val Cys Gly Glu Asp Gly Gln 
                485                 490                 495     


Phe Thr Tyr Cys Trp His Asp Asp Ile Met Gln Ala Val Phe His Ile 
            500                 505                 510         


Ala Thr Leu Met Pro Thr Lys Asp Val Asp Lys His Arg Cys Asp Lys 
        515                 520                 525             


Lys Arg His Leu Gly Asn Asp Phe Val Ser Ile Val Tyr Asn Asp Ser 
    530                 535                 540                 


Gly Glu Asp Phe Lys Leu Gly Thr Ile Lys Gly Gln Phe Asn Phe Val 
545                 550                 555                 560 


His Val Ile Val Thr Pro Leu Asp Tyr Glu Cys Asn Leu Val Ser Leu 
                565                 570                 575     


Gln Cys Arg Lys Asp Met Glu Gly Leu Val Asp Thr Ser Val Ala Lys 
            580                 585                 590         


Ile Val Ser Asp Arg Asn Leu Pro Phe Val Ala Arg Gln Met Ala Leu 
        595                 600                 605             


His Ala Asn Met Ala Ser Gln Val His His Ser Arg Ser Asn Pro Thr 
    610                 615                 620                 


Asp Ile Tyr Pro Ser Lys Trp Ile Ala Arg Leu Arg His Ile Lys Arg 
625                 630                 635                 640 


Leu Arg Gln Arg Ile Cys Glu Glu Ala Ala Tyr Ser Asn Pro Ser Leu 
                645                 650                 655     


Pro Leu Val His Pro Pro Ser His Ser Lys Ala Pro Ala Gln Thr Pro 
            660                 665                 670         


Ala Glu Pro Thr Pro Gly Tyr Glu Val Gly Gln Arg Lys Arg Leu Ile 
        675                 680                 685             


Ser Ser Val Glu Asp Phe Thr Glu Phe Val 
    690                 695             


<210>  9
<211>  875
<212>  PRT
<213>  Homo sapiens

<400>  9

Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro Lys Ser Leu Arg 
1               5                   10                  15      


Ile Ala Arg Pro Pro Lys Gln Gly Leu Asn Asn Ser Pro Pro Val Lys 
            20                  25                  30          


Glu Phe Lys Glu Ser Ser Ala Ala Glu Ala Phe Arg Cys Arg Ser Ile 
        35                  40                  45              


Ser Val Ser Glu His Val Val Arg Ser Arg Ile Gln Thr Ser Leu Thr 
    50                  55                  60                  


Ser Ala Ser Leu Gly Ser Ala Asp Glu Asn Ser Val Ala Gln Ala Asp 
65                  70                  75                  80  


Asp Ser Leu Lys Asn Leu His Leu Glu Leu Thr Glu Thr Cys Leu Asp 
                85                  90                  95      


Met Met Ala Arg Tyr Val Phe Ser Asn Phe Thr Ala Val Pro Lys Arg 
            100                 105                 110         


Ser Pro Val Gly Glu Phe Leu Leu Ala Gly Gly Arg Thr Lys Thr Trp 
        115                 120                 125             


Leu Val Gly Asn Lys Leu Val Thr Val Thr Thr Ser Val Gly Thr Gly 
    130                 135                 140                 


Thr Arg Ser Leu Leu Gly Leu Asp Ser Gly Glu Leu Gln Ser Gly Pro 
145                 150                 155                 160 


Glu Ser Ser Ser Ser Pro Gly Val His Val Arg Gln Thr Lys Glu Ala 
                165                 170                 175     


Pro Ala Lys Leu Glu Ser Gln Ala Gly Gln Gln Val Ser Arg Gly Ala 
            180                 185                 190         


Arg Asp Arg Val Arg Ser Met Ser Gly Gly His Gly Leu Arg Val Gly 
        195                 200                 205             


Ala Leu Asp Val Pro Ala Ser Gln Phe Leu Gly Ser Ala Thr Ser Pro 
    210                 215                 220                 


Gly Pro Arg Thr Ala Pro Ala Ala Lys Pro Glu Lys Ala Ser Ala Gly 
225                 230                 235                 240 


Thr Arg Val Pro Val Gln Glu Lys Thr Asn Leu Ala Ala Tyr Val Pro 
                245                 250                 255     


Leu Leu Thr Gln Gly Trp Ala Glu Ile Leu Val Arg Arg Pro Thr Gly 
            260                 265                 270         


Asn Thr Ser Trp Leu Met Ser Leu Glu Asn Pro Leu Ser Pro Phe Ser 
        275                 280                 285             


Ser Asp Ile Asn Asn Met Pro Leu Gln Glu Leu Ser Asn Ala Leu Met 
    290                 295                 300                 


Ala Ala Glu Arg Phe Lys Glu His Arg Asp Thr Ala Leu Tyr Lys Ser 
305                 310                 315                 320 


Leu Ser Val Pro Ala Ala Ser Thr Ala Lys Pro Pro Pro Leu Pro Arg 
                325                 330                 335     


Ser Asn Thr Val Ala Ser Phe Ser Ser Leu Tyr Gln Ser Ser Cys Gln 
            340                 345                 350         


Gly Gln Leu His Arg Ser Val Ser Trp Ala Asp Ser Ala Val Val Met 
        355                 360                 365             


Glu Glu Gly Ser Pro Gly Glu Val Pro Val Leu Val Glu Pro Pro Gly 
    370                 375                 380                 


Leu Glu Asp Val Glu Ala Ala Leu Gly Met Asp Arg Arg Thr Asp Ala 
385                 390                 395                 400 


Tyr Ser Arg Ser Ser Ser Val Ser Ser Gln Glu Glu Lys Ser Leu His 
                405                 410                 415     


Ala Glu Glu Leu Val Gly Arg Gly Ile Pro Ile Glu Arg Val Val Ser 
            420                 425                 430         


Ser Glu Gly Gly Arg Pro Ser Val Asp Leu Ser Phe Gln Pro Ser Gln 
        435                 440                 445             


Pro Leu Ser Lys Ser Ser Ser Ser Pro Glu Leu Gln Thr Leu Gln Asp 
    450                 455                 460                 


Ile Leu Gly Asp Pro Gly Asp Lys Ala Asp Val Gly Arg Leu Ser Pro 
465                 470                 475                 480 


Glu Val Lys Ala Arg Ser Gln Ser Gly Thr Leu Asp Gly Glu Ser Ala 
                485                 490                 495     


Ala Trp Ser Ala Ser Gly Glu Asp Ser Arg Gly Gln Pro Glu Gly Pro 
            500                 505                 510         


Leu Pro Ser Ser Ser Pro Arg Ser Pro Ser Gly Leu Arg Pro Arg Gly 
        515                 520                 525             


Tyr Thr Ile Ser Asp Ser Ala Pro Ser Arg Arg Gly Lys Arg Val Glu 
    530                 535                 540                 


Arg Asp Ala Leu Lys Ser Arg Ala Thr Ala Ser Asn Ala Glu Lys Val 
545                 550                 555                 560 


Pro Gly Ile Asn Pro Ser Phe Val Phe Leu Gln Leu Tyr His Ser Pro 
                565                 570                 575     


Phe Phe Gly Asp Glu Ser Asn Lys Pro Ile Leu Leu Pro Asn Glu Ser 
            580                 585                 590         


Gln Ser Phe Glu Arg Ser Val Gln Leu Leu Asp Gln Ile Pro Ser Tyr 
        595                 600                 605             


Asp Thr His Lys Ile Ala Val Leu Tyr Val Gly Glu Gly Gln Ser Asn 
    610                 615                 620                 


Ser Glu Leu Ala Ile Leu Ser Asn Glu His Gly Ser Tyr Arg Tyr Thr 
625                 630                 635                 640 


Glu Phe Leu Thr Gly Leu Gly Arg Leu Ile Glu Leu Lys Asp Cys Gln 
                645                 650                 655     


Pro Asp Lys Val Tyr Leu Gly Gly Leu Asp Val Cys Gly Glu Asp Gly 
            660                 665                 670         


Gln Phe Thr Tyr Cys Trp His Asp Asp Ile Met Gln Ala Val Phe His 
        675                 680                 685             


Ile Ala Thr Leu Met Pro Thr Lys Asp Val Asp Lys His Arg Cys Asp 
    690                 695                 700                 


Lys Lys Arg His Leu Gly Asn Asp Phe Val Ser Ile Val Tyr Asn Asp 
705                 710                 715                 720 


Ser Gly Glu Asp Phe Lys Leu Gly Thr Ile Lys Gly Gln Phe Asn Phe 
                725                 730                 735     


Val His Val Ile Val Thr Pro Leu Asp Tyr Glu Cys Asn Leu Val Ser 
            740                 745                 750         


Leu Gln Cys Arg Lys Asp Met Glu Gly Leu Val Asp Thr Ser Val Ala 
        755                 760                 765             


Lys Ile Val Ser Asp Arg Asn Leu Pro Phe Val Ala Arg Gln Met Ala 
    770                 775                 780                 


Leu His Ala Asn Met Ala Ser Gln Val His His Ser Arg Ser Asn Pro 
785                 790                 795                 800 


Thr Asp Ile Tyr Pro Ser Lys Trp Ile Ala Arg Leu Arg His Ile Lys 
                805                 810                 815     


Arg Leu Arg Gln Arg Ile Cys Glu Glu Ala Ala Tyr Ser Asn Pro Ser 
            820                 825                 830         


Leu Pro Leu Val His Pro Pro Ser His Ser Lys Ala Pro Ala Gln Thr 
        835                 840                 845             


Pro Ala Glu Pro Thr Pro Gly Tyr Glu Val Gly Gln Arg Lys Arg Leu 
    850                 855                 860                 


Ile Ser Ser Val Glu Asp Phe Thr Glu Phe Val 
865                 870                 875 


<210>  10
<211>  833
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  10

Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro Lys Ser Ser Arg 
1               5                   10                  15      


Ile Gln Thr Ser Leu Thr Ser Ala Ser Leu Gly Ser Ala Asp Glu Asn 
            20                  25                  30          


Ser Val Ala Gln Ala Asp Asp Ser Leu Lys Asn Leu His Leu Glu Leu 
        35                  40                  45              


Thr Glu Thr Cys Leu Asp Met Met Ala Arg Tyr Val Phe Ser Asn Phe 
    50                  55                  60                  


Thr Ala Val Pro Lys Arg Ser Pro Val Gly Glu Phe Leu Leu Ala Gly 
65                  70                  75                  80  


Gly Arg Thr Lys Thr Trp Leu Val Gly Asn Lys Leu Val Thr Val Thr 
                85                  90                  95      


Thr Ser Val Gly Thr Gly Thr Arg Ser Leu Leu Gly Leu Asp Ser Gly 
            100                 105                 110         


Glu Leu Gln Ser Gly Pro Glu Ser Ser Ser Ser Pro Gly Val His Val 
        115                 120                 125             


Arg Gln Thr Lys Glu Ala Pro Ala Lys Leu Glu Ser Gln Ala Gly Gln 
    130                 135                 140                 


Gln Val Ser Arg Gly Ala Arg Asp Arg Val Arg Ser Met Ser Gly Gly 
145                 150                 155                 160 


His Gly Leu Arg Val Gly Ala Leu Asp Val Pro Ala Ser Gln Phe Leu 
                165                 170                 175     


Gly Ser Ala Thr Ser Pro Gly Pro Arg Thr Ala Pro Ala Ala Lys Pro 
            180                 185                 190         


Glu Lys Ala Ser Ala Gly Thr Arg Val Pro Val Gln Glu Lys Thr Asn 
        195                 200                 205             


Leu Ala Ala Tyr Val Pro Leu Leu Thr Gln Gly Trp Ala Glu Ile Leu 
    210                 215                 220                 


Val Arg Arg Pro Thr Gly Asn Thr Ser Trp Leu Met Ser Leu Glu Asn 
225                 230                 235                 240 


Pro Leu Ser Pro Phe Ser Ser Asp Ile Asn Asn Met Pro Leu Gln Glu 
                245                 250                 255     


Leu Ser Asn Ala Leu Met Ala Ala Glu Arg Phe Lys Glu His Arg Asp 
            260                 265                 270         


Thr Ala Leu Tyr Lys Ser Leu Ser Val Pro Ala Ala Ser Thr Ala Lys 
        275                 280                 285             


Pro Pro Pro Leu Pro Arg Ser Asn Thr Val Ala Ser Phe Ser Ser Leu 
    290                 295                 300                 


Tyr Gln Ser Ser Cys Gln Gly Gln Leu His Arg Ser Val Ser Trp Ala 
305                 310                 315                 320 


Asp Ser Ala Val Val Met Glu Glu Gly Ser Pro Gly Glu Val Pro Val 
                325                 330                 335     


Leu Val Glu Pro Pro Gly Leu Glu Asp Val Glu Ala Ala Leu Gly Met 
            340                 345                 350         


Asp Arg Arg Thr Asp Ala Tyr Ser Arg Ser Ser Ser Val Ser Ser Gln 
        355                 360                 365             


Glu Glu Lys Ser Leu His Ala Glu Glu Leu Val Gly Arg Gly Ile Pro 
    370                 375                 380                 


Ile Glu Arg Val Val Ser Ser Glu Gly Gly Arg Pro Ser Val Asp Leu 
385                 390                 395                 400 


Ser Phe Gln Pro Ser Gln Pro Leu Ser Lys Ser Ser Ser Ser Pro Glu 
                405                 410                 415     


Leu Gln Thr Leu Gln Asp Ile Leu Gly Asp Pro Gly Asp Lys Ala Asp 
            420                 425                 430         


Val Gly Arg Leu Ser Pro Glu Val Lys Ala Arg Ser Gln Ser Gly Thr 
        435                 440                 445             


Leu Asp Gly Glu Ser Ala Ala Trp Ser Ala Ser Gly Glu Asp Ser Arg 
    450                 455                 460                 


Gly Gln Pro Glu Gly Pro Leu Pro Ser Ser Ser Pro Arg Ser Pro Ser 
465                 470                 475                 480 


Gly Leu Arg Pro Arg Gly Tyr Thr Ile Ser Asp Ser Ala Pro Ser Arg 
                485                 490                 495     


Arg Gly Lys Arg Val Glu Arg Asp Ala Leu Lys Ser Arg Ala Thr Ala 
            500                 505                 510         


Ser Asn Ala Glu Lys Val Pro Gly Ile Asn Pro Ser Phe Val Phe Leu 
        515                 520                 525             


Gln Leu Tyr His Ser Pro Phe Phe Gly Asp Glu Ser Asn Lys Pro Ile 
    530                 535                 540                 


Leu Leu Pro Asn Glu Ser Gln Ser Phe Glu Arg Ser Val Gln Leu Leu 
545                 550                 555                 560 


Asp Gln Ile Pro Ser Tyr Asp Thr His Lys Ile Ala Val Leu Tyr Val 
                565                 570                 575     


Gly Glu Gly Gln Ser Asn Ser Glu Leu Ala Ile Leu Ser Asn Glu His 
            580                 585                 590         


Gly Ser Tyr Arg Tyr Thr Glu Phe Leu Thr Gly Leu Gly Arg Leu Ile 
        595                 600                 605             


Glu Leu Lys Asp Cys Gln Pro Asp Lys Val Tyr Leu Gly Gly Leu Asp 
    610                 615                 620                 


Val Cys Gly Glu Asp Gly Gln Phe Thr Tyr Cys Trp His Asp Asp Ile 
625                 630                 635                 640 


Met Gln Ala Val Phe His Ile Ala Thr Leu Met Pro Thr Lys Asp Val 
                645                 650                 655     


Asp Lys His Arg Cys Asp Lys Lys Arg His Leu Gly Asn Asp Phe Val 
            660                 665                 670         


Ser Ile Val Tyr Asn Asp Ser Gly Glu Asp Phe Lys Leu Gly Thr Ile 
        675                 680                 685             


Lys Gly Gln Phe Asn Phe Val His Val Ile Val Thr Pro Leu Asp Tyr 
    690                 695                 700                 


Glu Cys Asn Leu Val Ser Leu Gln Cys Arg Lys Asp Met Glu Gly Leu 
705                 710                 715                 720 


Val Asp Thr Ser Val Ala Lys Ile Val Ser Asp Arg Asn Leu Pro Phe 
                725                 730                 735     


Val Ala Arg Gln Met Ala Leu His Ala Asn Met Ala Ser Gln Val His 
            740                 745                 750         


His Ser Arg Ser Asn Pro Thr Asp Ile Tyr Pro Ser Lys Trp Ile Ala 
        755                 760                 765             


Arg Leu Arg His Ile Lys Arg Leu Arg Gln Arg Ile Cys Glu Glu Ala 
    770                 775                 780                 


Ala Tyr Ser Asn Pro Ser Leu Pro Leu Val His Pro Pro Ser His Ser 
785                 790                 795                 800 


Lys Ala Pro Ala Gln Thr Pro Ala Glu Pro Thr Pro Gly Tyr Glu Val 
                805                 810                 815     


Gly Gln Arg Lys Arg Leu Ile Ser Ser Val Glu Asp Phe Thr Glu Phe 
            820                 825                 830         


Val 
    


<210>  11
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  11

Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro Lys Ser Ser Arg 
1               5                   10                  15      


Ile Gln Thr Ser Leu Thr Ser Ala Ser Leu Gly Ser Ala Asp Glu Asn 
            20                  25                  30          


Ser Val Ala Gln Ala Asp Asp Ser Leu Lys Asn Leu His Leu Glu Leu 
        35                  40                  45              


Thr Glu Thr Cys Leu Asp Met Met Ala Arg Tyr Val Phe Ser Asn Phe 
    50                  55                  60                  


Thr Ala Val Pro Lys Arg Ser Pro Val Gly Glu Phe Leu Leu Ala Gly 
65                  70                  75                  80  


Gly Arg Thr Lys Thr Trp Leu Val Gly Asn Lys Leu Val Thr Val Thr 
                85                  90                  95      


Thr Ser Val Gly Thr Gly Thr Arg Ser Leu Leu Gly Leu Asp Ser Gly 
            100                 105                 110         


Glu Leu Gln Ser Gly Pro Glu Ser Ser Ser Ser Pro Gly Val His Val 
        115                 120                 125             


Arg Gln Thr Lys Glu Ala Pro Ala Lys Leu Glu Ser Gln Ala Gly Gln 
    130                 135                 140                 


Gln Val Ser Arg Gly Ala Arg Asp Arg Val Arg Ser Met Ser Gly Gly 
145                 150                 155                 160 


His Gly Leu Arg Val Gly Ala Leu Asp Val Pro Ala Ser Gln Phe Leu 
                165                 170                 175     


Gly Ser Ala Thr Ser Pro Gly Pro Arg Thr Ala Pro Ala Ala Lys Pro 
            180                 185                 190         


Glu Lys Ala Ser Ala Gly Thr Arg Val Pro Val Gln Glu Lys Thr Asn 
        195                 200                 205             


Leu Ala Ala Tyr Val Pro Leu Leu Thr Gln Gly Trp Ala Glu Ile Leu 
    210                 215                 220                 


Val Arg Arg Pro Thr Gly Val Ala Ser Phe Ser Ser Leu Tyr Gln Ser 
225                 230                 235                 240 


Ser Cys Gln Gly Gln Leu His Arg Ser Val Ser Trp Ala Asp Ser Ala 
                245                 250                 255     


Val Val Met Glu Glu Gly Ser Pro Gly Glu Val Pro Val Leu Val Glu 
            260                 265                 270         


Pro Pro Gly Leu Glu Asp Val Glu Ala Ala Leu Gly Met Asp Arg Arg 
        275                 280                 285             


Thr Asp Ala Tyr Ser Arg Ser Ser Ser Val Ser Ser Gln Glu Glu Lys 
    290                 295                 300                 


Ser Leu His Ala Glu Glu Leu Val Gly Arg Gly Ile Pro Ile Glu Arg 
305                 310                 315                 320 


Val Val Ser Ser Glu Gly Gly Arg Pro Ser Val Asp Leu Ser Phe Gln 
                325                 330                 335     


Pro Ser Gln Pro Leu Ser Lys Ser Ser Ser Ser Pro Glu Leu Gln Thr 
            340                 345                 350         


Leu Gln Asp Ile Leu Gly Asp Pro Gly Asp Lys Ala Asp Val Gly Arg 
        355                 360                 365             


Leu Ser Pro Glu Val Lys Ala Arg Ser Gln Ser Gly Thr Leu Asp Gly 
    370                 375                 380                 


Glu Ser Ala Ala Trp Ser Ala Ser Gly Glu Asp Ser Arg Gly Gln Pro 
385                 390                 395                 400 


Glu Gly Pro Leu Pro Ser Ser Ser Pro Arg Ser Pro Ser Gly Leu Arg 
                405                 410                 415     


Pro Arg Gly Tyr Thr Ile Ser Asp Ser Ala Pro Ser Arg Arg Gly Lys 
            420                 425                 430         


Arg Val Glu Arg Asp Ala Leu Lys Ser Arg Ala Thr Ala Ser Asn Ala 
        435                 440                 445             


Glu Lys Val Pro Gly Ile Asn Pro Ser Phe Val Phe Leu Gln Leu Tyr 
    450                 455                 460                 


His Ser Pro Phe Phe Gly Asp Glu Ser Asn Lys Pro Ile Leu Leu Pro 
465                 470                 475                 480 


Asn Glu Ser Gln Ser Phe Glu Arg Ser Val Gln Leu Leu Asp Gln Ile 
                485                 490                 495     


Pro Ser Tyr Asp Thr His Lys Ile Ala Val Leu Tyr Val Gly Glu Gly 
            500                 505                 510         


Gln Ser Asn Ser Glu Leu Ala Ile Leu Ser Asn Glu His Gly Ser Tyr 
        515                 520                 525             


Arg Tyr Thr Glu Phe Leu Thr Gly Leu Gly Arg Leu Ile Glu Leu Lys 
    530                 535                 540                 


Asp Cys Gln Pro Asp Lys Val Tyr Leu Gly Gly Leu Asp Val Cys Gly 
545                 550                 555                 560 


Glu Asp Gly Gln Phe Thr Tyr Cys Trp His Asp Asp Ile Met Gln Ala 
                565                 570                 575     


Val Phe His Ile Ala Thr Leu Met Pro Thr Lys Asp Val Asp Lys His 
            580                 585                 590         


Arg Cys Asp Lys Lys Arg His Leu Gly Asn Asp Phe Val Ser Ile Val 
        595                 600                 605             


Tyr Asn Asp Ser Gly Glu Asp Phe Lys Leu Gly Thr Ile Lys Gly Gln 
    610                 615                 620                 


Phe Asn Phe Val His Val Ile Val Thr Pro Leu Asp Tyr Glu Cys Asn 
625                 630                 635                 640 


Leu Val Ser Leu Gln Cys Arg Lys Asp Met Glu Gly Leu Val Asp Thr 
                645                 650                 655     


Ser Val Ala Lys Ile Val Ser Asp Arg Asn Leu Pro Phe Val Ala Arg 
            660                 665                 670         


Gln Met Ala Leu His Ala Asn Met Ala Ser Gln Val His His Ser Arg 
        675                 680                 685             


Ser Asn Pro Thr Asp Ile Tyr Pro Ser Lys Trp Ile Ala Arg Leu Arg 
    690                 695                 700                 


His Ile Lys Arg Leu Arg Gln Arg Ile Cys Glu Glu Ala Ala Tyr Ser 
705                 710                 715                 720 


Asn Pro Ser Leu Pro Leu Val His Pro Pro Ser His Ser Lys Ala Pro 
                725                 730                 735     


Ala Gln Thr Pro Ala Glu Pro Thr Pro Gly Tyr Glu Val Gly Gln Arg 
            740                 745                 750         


Lys Arg Leu Ile Ser Ser Val Glu Asp Phe Thr Glu Phe Val 
        755                 760                 765     


<210>  12
<211>  604
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  12

Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro Lys Ser Ser Arg 
1               5                   10                  15      


Ile Gln Thr Ser Leu Thr Ser Ala Ser Leu Gly Ser Ala Asp Glu Asn 
            20                  25                  30          


Ser Val Ala Gln Ala Asp Asp Ser Leu Lys Asn Leu His Leu Glu Leu 
        35                  40                  45              


Thr Glu Thr Cys Leu Asp Met Met Ala Arg Tyr Val Phe Ser Asn Phe 
    50                  55                  60                  


Thr Ala Val Pro Lys Arg Ser Pro Val Gly Glu Phe Leu Leu Ala Gly 
65                  70                  75                  80  


Gly Arg Thr Lys Thr Trp Leu Val Gly Asn Lys Leu Val Thr Val Thr 
                85                  90                  95      


Thr Ser Val Gly Thr Gly Thr Arg Ser Leu Leu Gly Leu Asp Ser Gly 
            100                 105                 110         


Glu Leu Gln Ser Gly Pro Glu Ser Ser Ser Ser Pro Gly Val His Val 
        115                 120                 125             


Arg Gln Thr Lys Glu Ala Pro Ala Lys Leu Glu Ser Gln Ala Gly Gln 
    130                 135                 140                 


Gln Val Ser Arg Gly Ala Arg Asp Arg Val Arg Ser Met Ser Gly Gly 
145                 150                 155                 160 


His Gly Leu Arg Val Gly Ala Leu Asp Val Pro Ala Ser Gln Phe Leu 
                165                 170                 175     


Gly Ser Ala Thr Ser Pro Gly Pro Arg Thr Ala Pro Ala Ala Lys Pro 
            180                 185                 190         


Glu Lys Ala Ser Ala Gly Thr Arg Val Pro Val Gln Glu Lys Thr Asn 
        195                 200                 205             


Leu Ala Ala Tyr Val Pro Leu Leu Thr Gln Gly Trp Ala Glu Ile Leu 
    210                 215                 220                 


Val Arg Arg Pro Thr Gly Val Ala Ser Phe Ser Ser Leu Tyr Gln Ser 
225                 230                 235                 240 


Ser Cys Gln Gly Gln Leu His Arg Ser Val Ser Trp Ala Asp Ser Ala 
                245                 250                 255     


Val Val Met Glu Glu Gly Ser Pro Gly Glu Val Pro Val Leu Val Glu 
            260                 265                 270         


Pro Pro Gly Leu Glu Asp Val Glu Ala Ala Leu Gly Met Asp Arg Arg 
        275                 280                 285             


Thr Asp Ala Tyr Ser Arg Ser Phe Val Phe Leu Gln Leu Tyr His Ser 
    290                 295                 300                 


Pro Phe Phe Gly Asp Glu Ser Asn Lys Pro Ile Leu Leu Pro Asn Glu 
305                 310                 315                 320 


Ser Gln Ser Phe Glu Arg Ser Val Gln Leu Leu Asp Gln Ile Pro Ser 
                325                 330                 335     


Tyr Asp Thr His Lys Ile Ala Val Leu Tyr Val Gly Glu Gly Gln Ser 
            340                 345                 350         


Asn Ser Glu Leu Ala Ile Leu Ser Asn Glu His Gly Ser Tyr Arg Tyr 
        355                 360                 365             


Thr Glu Phe Leu Thr Gly Leu Gly Arg Leu Ile Glu Leu Lys Asp Cys 
    370                 375                 380                 


Gln Pro Asp Lys Val Tyr Leu Gly Gly Leu Asp Val Cys Gly Glu Asp 
385                 390                 395                 400 


Gly Gln Phe Thr Tyr Cys Trp His Asp Asp Ile Met Gln Ala Val Phe 
                405                 410                 415     


His Ile Ala Thr Leu Met Pro Thr Lys Asp Val Asp Lys His Arg Cys 
            420                 425                 430         


Asp Lys Lys Arg His Leu Gly Asn Asp Phe Val Ser Ile Val Tyr Asn 
        435                 440                 445             


Asp Ser Gly Glu Asp Phe Lys Leu Gly Thr Ile Lys Gly Gln Phe Asn 
    450                 455                 460                 


Phe Val His Val Ile Val Thr Pro Leu Asp Tyr Glu Cys Asn Leu Val 
465                 470                 475                 480 


Ser Leu Gln Cys Arg Lys Asp Met Glu Gly Leu Val Asp Thr Ser Val 
                485                 490                 495     


Ala Lys Ile Val Ser Asp Arg Asn Leu Pro Phe Val Ala Arg Gln Met 
            500                 505                 510         


Ala Leu His Ala Asn Met Ala Ser Gln Val His His Ser Arg Ser Asn 
        515                 520                 525             


Pro Thr Asp Ile Tyr Pro Ser Lys Trp Ile Ala Arg Leu Arg His Ile 
    530                 535                 540                 


Lys Arg Leu Arg Gln Arg Ile Cys Glu Glu Ala Ala Tyr Ser Asn Pro 
545                 550                 555                 560 


Ser Leu Pro Leu Val His Pro Pro Ser His Ser Lys Ala Pro Ala Gln 
                565                 570                 575     


Thr Pro Ala Glu Pro Thr Pro Gly Tyr Glu Val Gly Gln Arg Lys Arg 
            580                 585                 590         


Leu Ile Ser Ser Val Glu Asp Phe Thr Glu Phe Val 
        595                 600                 


<210>  13
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  13

Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
1               5                   10                  15      


Ile Leu Leu Gly Leu Gly Thr Pro Arg Pro Asn Pro Arg Ser Ala Glu 
            20                  25                  30          


Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
        35                  40                  45              


Ser Met Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
    50                  55                  60                  


Cys Glu Val Ala Lys Thr Lys Lys Phe Glu Glu His Ala Val Glu Ala 
65                  70                  75                  80  


Leu Trp Lys Ala Val Ala Asp Leu Leu Gln Pro Glu Arg Pro Leu Glu 
                85                  90                  95      


Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
            100                 105                 110         


Gly Glu Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
        115                 120                 125             


Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
    130                 135                 140                 


Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
145                 150                 155                 160 


Ala Asp Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                165                 170                 175     


Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
            180                 185                 190         


Glu Tyr Ile Ala Arg Met Val Gln Met Ile Cys Leu Leu Cys Val Arg 
        195                 200                 205             


Thr Ala Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
    210                 215                 220                 


Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
225                 230                 235                 240 


Val Thr Leu Cys Arg Thr Ile Asn Val Lys Glu Leu Cys Glu Pro Cys 
                245                 250                 255     


Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
            260                 265                 270         


Ile Tyr Asn Met Cys His Leu Met Glu Asp Arg Ala Tyr Met Glu Asp 
        275                 280                 285             


Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
    290                 295                 300                 


Gly Ala His Arg Leu Tyr Ser Leu Arg Asn Ser Pro Thr Ser Val Leu 
305                 310                 315                 320 


Pro Ser Phe Tyr Gln Ala Met Ala Cys Pro Asn Glu Val Val Ser Tyr 
                325                 330                 335     


Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
            340                 345                 350         


Leu Gln Val Val Ala Trp Asp Ile Leu Leu Asn Ile Ile Glu Arg Leu 
        355                 360                 365             


Leu Gln Gln Leu Gln Thr Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
    370                 375                 380                 


His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
385                 390                 395                 400 


His Gly Ser Gln Glu Arg Tyr Phe Glu Leu Val Glu Arg Cys Ala Asp 
                405                 410                 415     


Gln Arg Pro Glu Ser Ser Leu Leu Asn Leu Ile Ser Tyr Arg Ala Gln 
            420                 425                 430         


Ser Ile His Pro Ala Lys Asp Gly Trp Ile Gln Asn Leu Gln Ala Leu 
        435                 440                 445             


Met Glu Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
    450                 455                 460                 


Gly Gly Lys Pro Ile Leu Leu Pro Asn Glu Ser Gln Ser Phe Glu Arg 
465                 470                 475                 480 


Ser Val Gln Leu Leu Asp Gln Ile Pro Ser Tyr Asp Thr His Lys Ile 
                485                 490                 495     


Ala Val Leu Tyr Val Gly Glu Gly Gln Ser Asn Ser Glu Leu Ala Ile 
            500                 505                 510         


Leu Ser Asn Glu His Gly Ser Tyr Arg Tyr Thr Glu Phe Leu Thr Gly 
        515                 520                 525             


Leu Gly Arg Leu Ile Glu Leu Lys Asp Cys Gln Pro Asp Lys Val Tyr 
    530                 535                 540                 


Leu Gly Gly Leu Asp Val Cys Gly Glu Asp Gly Gln Phe Thr Tyr Cys 
545                 550                 555                 560 


Trp His Asp Asp Ile Met Gln Ala Val Phe His Ile Ala Thr Leu Met 
                565                 570                 575     


Pro Thr Lys Asp Val Asp Lys His Arg Cys Asp Lys Lys Arg His Leu 
            580                 585                 590         


Gly Asn Asp Phe Val Ser Ile Val Tyr Asn Asp Ser Gly Glu Asp Phe 
        595                 600                 605             


Lys Leu Gly Thr Ile Lys Gly Gln Phe Asn Phe Val His Val Ile Val 
    610                 615                 620                 


Thr Pro Leu Asp Tyr Glu Cys Asn Leu Val Ser Leu Gln Cys Arg Lys 
625                 630                 635                 640 


Asp Met Glu Gly Leu Val Asp Thr Ser Val Ala Lys Ile Val Ser Asp 
                645                 650                 655     


Arg Asn Leu Pro Phe Val Ala Arg Gln Met Ala Leu His Ala Asn Met 
            660                 665                 670         


Ala Ser Gln Val His His Ser Arg Ser Asn Pro Thr Asp Ile Tyr Pro 
        675                 680                 685             


Ser Lys Trp Ile Ala Arg Leu Arg His Ile Lys Arg Leu Arg Gln Arg 
    690                 695                 700                 


Ile Cys Glu Glu Ala Ala Tyr Ser Asn Pro Ser Leu Pro Leu Val His 
705                 710                 715                 720 


Pro Pro Ser His Ser Lys Ala Pro Ala Gln Thr Pro Ala Glu Pro Thr 
                725                 730                 735     


Pro Gly Tyr Glu Val Gly Gln Arg Lys Arg Leu Ile Ser Ser Val Glu 
            740                 745                 750         


Asp Phe Thr Glu Phe Val 
        755             


<210>  14
<211>  1134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  14

Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
1               5                   10                  15      


Ile Leu Leu Gly Leu Gly Thr Pro Arg Pro Asn Pro Arg Ser Ala Glu 
            20                  25                  30          


Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
        35                  40                  45              


Ser Met Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
    50                  55                  60                  


Cys Glu Val Ala Lys Thr Lys Lys Phe Glu Glu His Ala Val Glu Ala 
65                  70                  75                  80  


Leu Trp Lys Ala Val Ala Asp Leu Leu Gln Pro Glu Arg Pro Leu Glu 
                85                  90                  95      


Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
            100                 105                 110         


Gly Glu Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
        115                 120                 125             


Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
    130                 135                 140                 


Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
145                 150                 155                 160 


Ala Asp Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                165                 170                 175     


Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
            180                 185                 190         


Glu Tyr Ile Ala Arg Met Val Gln Met Ile Cys Leu Leu Cys Val Arg 
        195                 200                 205             


Thr Ala Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
    210                 215                 220                 


Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
225                 230                 235                 240 


Val Thr Leu Cys Arg Thr Ile Asn Val Lys Glu Leu Cys Glu Pro Cys 
                245                 250                 255     


Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
            260                 265                 270         


Ile Tyr Asn Met Cys His Leu Met Glu Asp Arg Ala Tyr Met Glu Asp 
        275                 280                 285             


Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
    290                 295                 300                 


Gly Ala His Arg Leu Tyr Ser Leu Arg Asn Ser Pro Thr Ser Val Leu 
305                 310                 315                 320 


Pro Ser Phe Tyr Gln Ala Met Ala Cys Pro Asn Glu Val Val Ser Tyr 
                325                 330                 335     


Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
            340                 345                 350         


Leu Gln Val Val Ala Trp Asp Ile Leu Leu Asn Ile Ile Glu Arg Leu 
        355                 360                 365             


Leu Gln Gln Leu Gln Thr Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
    370                 375                 380                 


His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
385                 390                 395                 400 


His Gly Ser Gln Glu Arg Tyr Phe Glu Leu Val Glu Arg Cys Ala Asp 
                405                 410                 415     


Gln Arg Pro Glu Ser Ser Leu Leu Asn Leu Ile Ser Tyr Arg Ala Gln 
            420                 425                 430         


Ser Ile His Pro Ala Lys Asp Gly Trp Ile Gln Asn Leu Gln Ala Leu 
        435                 440                 445             


Met Glu Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
    450                 455                 460                 


Gly Gly Gly Ala Leu Asp Val Pro Ala Ser Gln Phe Leu Gly Ser Ala 
465                 470                 475                 480 


Thr Ser Pro Gly Pro Arg Thr Ala Pro Ala Ala Lys Pro Glu Lys Ala 
                485                 490                 495     


Ser Ala Gly Thr Arg Val Pro Val Gln Glu Lys Thr Asn Leu Ala Ala 
            500                 505                 510         


Tyr Val Pro Leu Leu Thr Gln Gly Trp Ala Glu Ile Leu Val Arg Arg 
        515                 520                 525             


Pro Thr Gly Asn Thr Ser Trp Leu Met Ser Leu Glu Asn Pro Leu Ser 
    530                 535                 540                 


Pro Phe Ser Ser Asp Ile Asn Asn Met Pro Leu Gln Glu Leu Ser Asn 
545                 550                 555                 560 


Ala Leu Met Ala Ala Glu Arg Phe Lys Glu His Arg Asp Thr Ala Leu 
                565                 570                 575     


Tyr Lys Ser Leu Ser Val Pro Ala Ala Ser Thr Ala Lys Pro Pro Pro 
            580                 585                 590         


Leu Pro Arg Ser Asn Thr Val Ala Ser Phe Ser Ser Leu Tyr Gln Ser 
        595                 600                 605             


Ser Cys Gln Gly Gln Leu His Arg Ser Val Ser Trp Ala Asp Ser Ala 
    610                 615                 620                 


Val Val Met Glu Glu Gly Ser Pro Gly Glu Val Pro Val Leu Val Glu 
625                 630                 635                 640 


Pro Pro Gly Leu Glu Asp Val Glu Ala Ala Leu Gly Met Asp Arg Arg 
                645                 650                 655     


Thr Asp Ala Tyr Ser Arg Ser Ser Ser Val Ser Ser Gln Glu Glu Lys 
            660                 665                 670         


Ser Leu His Ala Glu Glu Leu Val Gly Arg Gly Ile Pro Ile Glu Arg 
        675                 680                 685             


Val Val Ser Ser Glu Gly Gly Arg Pro Ser Val Asp Leu Ser Phe Gln 
    690                 695                 700                 


Pro Ser Gln Pro Leu Ser Lys Ser Ser Ser Ser Pro Glu Leu Gln Thr 
705                 710                 715                 720 


Leu Gln Asp Ile Leu Gly Asp Pro Gly Asp Lys Ala Asp Val Gly Arg 
                725                 730                 735     


Leu Ser Pro Glu Val Lys Ala Arg Ser Gln Ser Gly Thr Leu Asp Gly 
            740                 745                 750         


Glu Ser Ala Ala Trp Ser Ala Ser Gly Glu Asp Ser Arg Gly Gln Pro 
        755                 760                 765             


Glu Gly Pro Leu Pro Ser Ser Ser Pro Arg Ser Pro Ser Gly Leu Arg 
    770                 775                 780                 


Pro Arg Gly Tyr Thr Ile Ser Asp Ser Ala Pro Ser Arg Arg Gly Lys 
785                 790                 795                 800 


Arg Val Glu Arg Asp Ala Leu Lys Ser Arg Ala Thr Ala Ser Asn Ala 
                805                 810                 815     


Glu Lys Val Pro Gly Ile Asn Pro Ser Phe Val Phe Leu Gln Leu Tyr 
            820                 825                 830         


His Ser Pro Phe Phe Gly Asp Glu Ser Asn Lys Pro Ile Leu Leu Pro 
        835                 840                 845             


Asn Glu Ser Gln Ser Phe Glu Arg Ser Val Gln Leu Leu Asp Gln Ile 
    850                 855                 860                 


Pro Ser Tyr Asp Thr His Lys Ile Ala Val Leu Tyr Val Gly Glu Gly 
865                 870                 875                 880 


Gln Ser Asn Ser Glu Leu Ala Ile Leu Ser Asn Glu His Gly Ser Tyr 
                885                 890                 895     


Arg Tyr Thr Glu Phe Leu Thr Gly Leu Gly Arg Leu Ile Glu Leu Lys 
            900                 905                 910         


Asp Cys Gln Pro Asp Lys Val Tyr Leu Gly Gly Leu Asp Val Cys Gly 
        915                 920                 925             


Glu Asp Gly Gln Phe Thr Tyr Cys Trp His Asp Asp Ile Met Gln Ala 
    930                 935                 940                 


Val Phe His Ile Ala Thr Leu Met Pro Thr Lys Asp Val Asp Lys His 
945                 950                 955                 960 


Arg Cys Asp Lys Lys Arg His Leu Gly Asn Asp Phe Val Ser Ile Val 
                965                 970                 975     


Tyr Asn Asp Ser Gly Glu Asp Phe Lys Leu Gly Thr Ile Lys Gly Gln 
            980                 985                 990         


Phe Asn Phe Val His Val Ile Val  Thr Pro Leu Asp Tyr  Glu Cys Asn 
        995                 1000                 1005             


Leu Val  Ser Leu Gln Cys Arg  Lys Asp Met Glu Gly  Leu Val Asp 
    1010                 1015                 1020             


Thr Ser  Val Ala Lys Ile Val  Ser Asp Arg Asn Leu  Pro Phe Val 
    1025                 1030                 1035             


Ala Arg  Gln Met Ala Leu His  Ala Asn Met Ala Ser  Gln Val His 
    1040                 1045                 1050             


His Ser  Arg Ser Asn Pro Thr  Asp Ile Tyr Pro Ser  Lys Trp Ile 
    1055                 1060                 1065             


Ala Arg  Leu Arg His Ile Lys  Arg Leu Arg Gln Arg  Ile Cys Glu 
    1070                 1075                 1080             


Glu Ala  Ala Tyr Ser Asn Pro  Ser Leu Pro Leu Val  His Pro Pro 
    1085                 1090                 1095             


Ser His  Ser Lys Ala Pro Ala  Gln Thr Pro Ala Glu  Pro Thr Pro 
    1100                 1105                 1110             


Gly Tyr  Glu Val Gly Gln Arg  Lys Arg Leu Ile Ser  Ser Val Glu 
    1115                 1120                 1125             


Asp Phe  Thr Glu Phe Val 
    1130                 


<210>  15
<211>  1102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  15

Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
1               5                   10                  15      


Ile Leu Leu Gly Leu Gly Thr Pro Arg Pro Asn Pro Arg Ser Ala Glu 
            20                  25                  30          


Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
        35                  40                  45              


Ser Met Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
    50                  55                  60                  


Cys Glu Val Ala Lys Thr Lys Lys Phe Glu Glu His Ala Val Glu Ala 
65                  70                  75                  80  


Leu Trp Lys Ala Val Ala Asp Leu Leu Gln Pro Glu Arg Pro Leu Glu 
                85                  90                  95      


Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
            100                 105                 110         


Gly Glu Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
        115                 120                 125             


Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
    130                 135                 140                 


Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
145                 150                 155                 160 


Ala Asp Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                165                 170                 175     


Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
            180                 185                 190         


Glu Tyr Ile Ala Arg Met Val Gln Met Ile Cys Leu Leu Cys Val Arg 
        195                 200                 205             


Thr Ala Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
    210                 215                 220                 


Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
225                 230                 235                 240 


Val Thr Leu Cys Arg Thr Ile Asn Val Lys Glu Leu Cys Glu Pro Cys 
                245                 250                 255     


Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
            260                 265                 270         


Ile Tyr Asn Met Cys His Leu Met Glu Asp Arg Ala Tyr Met Glu Asp 
        275                 280                 285             


Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
    290                 295                 300                 


Gly Ala His Arg Leu Tyr Ser Leu Arg Asn Ser Pro Thr Ser Val Leu 
305                 310                 315                 320 


Pro Ser Phe Tyr Gln Ala Met Ala Cys Pro Asn Glu Val Val Ser Tyr 
                325                 330                 335     


Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
            340                 345                 350         


Leu Gln Val Val Ala Trp Asp Ile Leu Leu Asn Ile Ile Glu Arg Leu 
        355                 360                 365             


Leu Gln Gln Leu Gln Thr Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
    370                 375                 380                 


His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
385                 390                 395                 400 


His Gly Ser Gln Glu Arg Tyr Phe Glu Leu Val Glu Arg Cys Ala Asp 
                405                 410                 415     


Gln Arg Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ala Leu Asp Val Pro Ala Ser Gln Phe Leu Gly Ser Ala 
        435                 440                 445             


Thr Ser Pro Gly Pro Arg Thr Ala Pro Ala Ala Lys Pro Glu Lys Ala 
    450                 455                 460                 


Ser Ala Gly Thr Arg Val Pro Val Gln Glu Lys Thr Asn Leu Ala Ala 
465                 470                 475                 480 


Tyr Val Pro Leu Leu Thr Gln Gly Trp Ala Glu Ile Leu Val Arg Arg 
                485                 490                 495     


Pro Thr Gly Asn Thr Ser Trp Leu Met Ser Leu Glu Asn Pro Leu Ser 
            500                 505                 510         


Pro Phe Ser Ser Asp Ile Asn Asn Met Pro Leu Gln Glu Leu Ser Asn 
        515                 520                 525             


Ala Leu Met Ala Ala Glu Arg Phe Lys Glu His Arg Asp Thr Ala Leu 
    530                 535                 540                 


Tyr Lys Ser Leu Ser Val Pro Ala Ala Ser Thr Ala Lys Pro Pro Pro 
545                 550                 555                 560 


Leu Pro Arg Ser Asn Thr Val Ala Ser Phe Ser Ser Leu Tyr Gln Ser 
                565                 570                 575     


Ser Cys Gln Gly Gln Leu His Arg Ser Val Ser Trp Ala Asp Ser Ala 
            580                 585                 590         


Val Val Met Glu Glu Gly Ser Pro Gly Glu Val Pro Val Leu Val Glu 
        595                 600                 605             


Pro Pro Gly Leu Glu Asp Val Glu Ala Ala Leu Gly Met Asp Arg Arg 
    610                 615                 620                 


Thr Asp Ala Tyr Ser Arg Ser Ser Ser Val Ser Ser Gln Glu Glu Lys 
625                 630                 635                 640 


Ser Leu His Ala Glu Glu Leu Val Gly Arg Gly Ile Pro Ile Glu Arg 
                645                 650                 655     


Val Val Ser Ser Glu Gly Gly Arg Pro Ser Val Asp Leu Ser Phe Gln 
            660                 665                 670         


Pro Ser Gln Pro Leu Ser Lys Ser Ser Ser Ser Pro Glu Leu Gln Thr 
        675                 680                 685             


Leu Gln Asp Ile Leu Gly Asp Pro Gly Asp Lys Ala Asp Val Gly Arg 
    690                 695                 700                 


Leu Ser Pro Glu Val Lys Ala Arg Ser Gln Ser Gly Thr Leu Asp Gly 
705                 710                 715                 720 


Glu Ser Ala Ala Trp Ser Ala Ser Gly Glu Asp Ser Arg Gly Gln Pro 
                725                 730                 735     


Glu Gly Pro Leu Pro Ser Ser Ser Pro Arg Ser Pro Ser Gly Leu Arg 
            740                 745                 750         


Pro Arg Gly Tyr Thr Ile Ser Asp Ser Ala Pro Ser Arg Arg Gly Lys 
        755                 760                 765             


Arg Val Glu Arg Asp Ala Leu Lys Ser Arg Ala Thr Ala Ser Asn Ala 
    770                 775                 780                 


Glu Lys Val Pro Gly Ile Asn Pro Ser Phe Val Phe Leu Gln Leu Tyr 
785                 790                 795                 800 


His Ser Pro Phe Phe Gly Asp Glu Ser Asn Lys Pro Ile Leu Leu Pro 
                805                 810                 815     


Asn Glu Ser Gln Ser Phe Glu Arg Ser Val Gln Leu Leu Asp Gln Ile 
            820                 825                 830         


Pro Ser Tyr Asp Thr His Lys Ile Ala Val Leu Tyr Val Gly Glu Gly 
        835                 840                 845             


Gln Ser Asn Ser Glu Leu Ala Ile Leu Ser Asn Glu His Gly Ser Tyr 
    850                 855                 860                 


Arg Tyr Thr Glu Phe Leu Thr Gly Leu Gly Arg Leu Ile Glu Leu Lys 
865                 870                 875                 880 


Asp Cys Gln Pro Asp Lys Val Tyr Leu Gly Gly Leu Asp Val Cys Gly 
                885                 890                 895     


Glu Asp Gly Gln Phe Thr Tyr Cys Trp His Asp Asp Ile Met Gln Ala 
            900                 905                 910         


Val Phe His Ile Ala Thr Leu Met Pro Thr Lys Asp Val Asp Lys His 
        915                 920                 925             


Arg Cys Asp Lys Lys Arg His Leu Gly Asn Asp Phe Val Ser Ile Val 
    930                 935                 940                 


Tyr Asn Asp Ser Gly Glu Asp Phe Lys Leu Gly Thr Ile Lys Gly Gln 
945                 950                 955                 960 


Phe Asn Phe Val His Val Ile Val Thr Pro Leu Asp Tyr Glu Cys Asn 
                965                 970                 975     


Leu Val Ser Leu Gln Cys Arg Lys Asp Met Glu Gly Leu Val Asp Thr 
            980                 985                 990         


Ser Val Ala Lys Ile Val Ser Asp  Arg Asn Leu Pro Phe  Val Ala Arg 
        995                 1000                 1005             


Gln Met  Ala Leu His Ala Asn  Met Ala Ser Gln Val  His His Ser 
    1010                 1015                 1020             


Arg Ser  Asn Pro Thr Asp Ile  Tyr Pro Ser Lys Trp  Ile Ala Arg 
    1025                 1030                 1035             


Leu Arg  His Ile Lys Arg Leu  Arg Gln Arg Ile Cys  Glu Glu Ala 
    1040                 1045                 1050             


Ala Tyr  Ser Asn Pro Ser Leu  Pro Leu Val His Pro  Pro Ser His 
    1055                 1060                 1065             


Ser Lys  Ala Pro Ala Gln Thr  Pro Ala Glu Pro Thr  Pro Gly Tyr 
    1070                 1075                 1080             


Glu Val  Gly Gln Arg Lys Arg  Leu Ile Ser Ser Val  Glu Asp Phe 
    1085                 1090                 1095             


Thr Glu  Phe Val 
    1100         


<210>  16
<211>  1309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  16

Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
1               5                   10                  15      


Ile Leu Leu Gly Leu Gly Thr Pro Arg Pro Asn Pro Arg Ser Ala Glu 
            20                  25                  30          


Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
        35                  40                  45              


Ser Met Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
    50                  55                  60                  


Cys Glu Val Ala Lys Thr Lys Lys Phe Glu Glu His Ala Val Glu Ala 
65                  70                  75                  80  


Leu Trp Lys Ala Val Ala Asp Leu Leu Gln Pro Glu Arg Pro Leu Glu 
                85                  90                  95      


Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
            100                 105                 110         


Gly Glu Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
        115                 120                 125             


Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
    130                 135                 140                 


Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
145                 150                 155                 160 


Ala Asp Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                165                 170                 175     


Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
            180                 185                 190         


Glu Tyr Ile Ala Arg Met Val Gln Met Ile Cys Leu Leu Cys Val Arg 
        195                 200                 205             


Thr Ala Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
    210                 215                 220                 


Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
225                 230                 235                 240 


Val Thr Leu Cys Arg Thr Ile Asn Val Lys Glu Leu Cys Glu Pro Cys 
                245                 250                 255     


Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
            260                 265                 270         


Ile Tyr Asn Met Cys His Leu Met Glu Asp Arg Ala Tyr Met Glu Asp 
        275                 280                 285             


Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
    290                 295                 300                 


Gly Ala His Arg Leu Tyr Ser Leu Arg Asn Ser Pro Thr Ser Val Leu 
305                 310                 315                 320 


Pro Ser Phe Tyr Gln Ala Met Ala Cys Pro Asn Glu Val Val Ser Tyr 
                325                 330                 335     


Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
            340                 345                 350         


Leu Gln Val Val Ala Trp Asp Ile Leu Leu Asn Ile Ile Glu Arg Leu 
        355                 360                 365             


Leu Gln Gln Leu Gln Thr Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
    370                 375                 380                 


His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
385                 390                 395                 400 


His Gly Ser Gln Glu Arg Tyr Phe Glu Leu Val Glu Arg Cys Ala Asp 
                405                 410                 415     


Gln Arg Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro Lys Ser 
        435                 440                 445             


Leu Arg Ile Ala Arg Pro Pro Lys Gln Gly Leu Asn Asn Ser Pro Pro 
    450                 455                 460                 


Val Lys Glu Phe Lys Glu Ser Ser Ala Ala Glu Ala Phe Arg Cys Arg 
465                 470                 475                 480 


Ser Ile Ser Val Ser Glu His Val Val Arg Ser Arg Ile Gln Thr Ser 
                485                 490                 495     


Leu Thr Ser Ala Ser Leu Gly Ser Ala Asp Glu Asn Ser Val Ala Gln 
            500                 505                 510         


Ala Asp Asp Ser Leu Lys Asn Leu His Leu Glu Leu Thr Glu Thr Cys 
        515                 520                 525             


Leu Asp Met Met Ala Arg Tyr Val Phe Ser Asn Phe Thr Ala Val Pro 
    530                 535                 540                 


Lys Arg Ser Pro Val Gly Glu Phe Leu Leu Ala Gly Gly Arg Thr Lys 
545                 550                 555                 560 


Thr Trp Leu Val Gly Asn Lys Leu Val Thr Val Thr Thr Ser Val Gly 
                565                 570                 575     


Thr Gly Thr Arg Ser Leu Leu Gly Leu Asp Ser Gly Glu Leu Gln Ser 
            580                 585                 590         


Gly Pro Glu Ser Ser Ser Ser Pro Gly Val His Val Arg Gln Thr Lys 
        595                 600                 605             


Glu Ala Pro Ala Lys Leu Glu Ser Gln Ala Gly Gln Gln Val Ser Arg 
    610                 615                 620                 


Gly Ala Arg Asp Arg Val Arg Ser Met Ser Gly Gly His Gly Leu Arg 
625                 630                 635                 640 


Val Gly Ala Leu Asp Val Pro Ala Ser Gln Phe Leu Gly Ser Ala Thr 
                645                 650                 655     


Ser Pro Gly Pro Arg Thr Ala Pro Ala Ala Lys Pro Glu Lys Ala Ser 
            660                 665                 670         


Ala Gly Thr Arg Val Pro Val Gln Glu Lys Thr Asn Leu Ala Ala Tyr 
        675                 680                 685             


Val Pro Leu Leu Thr Gln Gly Trp Ala Glu Ile Leu Val Arg Arg Pro 
    690                 695                 700                 


Thr Gly Asn Thr Ser Trp Leu Met Ser Leu Glu Asn Pro Leu Ser Pro 
705                 710                 715                 720 


Phe Ser Ser Asp Ile Asn Asn Met Pro Leu Gln Glu Leu Ser Asn Ala 
                725                 730                 735     


Leu Met Ala Ala Glu Arg Phe Lys Glu His Arg Asp Thr Ala Leu Tyr 
            740                 745                 750         


Lys Ser Leu Ser Val Pro Ala Ala Ser Thr Ala Lys Pro Pro Pro Leu 
        755                 760                 765             


Pro Arg Ser Asn Thr Val Ala Ser Phe Ser Ser Leu Tyr Gln Ser Ser 
    770                 775                 780                 


Cys Gln Gly Gln Leu His Arg Ser Val Ser Trp Ala Asp Ser Ala Val 
785                 790                 795                 800 


Val Met Glu Glu Gly Ser Pro Gly Glu Val Pro Val Leu Val Glu Pro 
                805                 810                 815     


Pro Gly Leu Glu Asp Val Glu Ala Ala Leu Gly Met Asp Arg Arg Thr 
            820                 825                 830         


Asp Ala Tyr Ser Arg Ser Ser Ser Val Ser Ser Gln Glu Glu Lys Ser 
        835                 840                 845             


Leu His Ala Glu Glu Leu Val Gly Arg Gly Ile Pro Ile Glu Arg Val 
    850                 855                 860                 


Val Ser Ser Glu Gly Gly Arg Pro Ser Val Asp Leu Ser Phe Gln Pro 
865                 870                 875                 880 


Ser Gln Pro Leu Ser Lys Ser Ser Ser Ser Pro Glu Leu Gln Thr Leu 
                885                 890                 895     


Gln Asp Ile Leu Gly Asp Pro Gly Asp Lys Ala Asp Val Gly Arg Leu 
            900                 905                 910         


Ser Pro Glu Val Lys Ala Arg Ser Gln Ser Gly Thr Leu Asp Gly Glu 
        915                 920                 925             


Ser Ala Ala Trp Ser Ala Ser Gly Glu Asp Ser Arg Gly Gln Pro Glu 
    930                 935                 940                 


Gly Pro Leu Pro Ser Ser Ser Pro Arg Ser Pro Ser Gly Leu Arg Pro 
945                 950                 955                 960 


Arg Gly Tyr Thr Ile Ser Asp Ser Ala Pro Ser Arg Arg Gly Lys Arg 
                965                 970                 975     


Val Glu Arg Asp Ala Leu Lys Ser Arg Ala Thr Ala Ser Asn Ala Glu 
            980                 985                 990         


Lys Val Pro Gly Ile Asn Pro Ser  Phe Val Phe Leu Gln  Leu Tyr His 
        995                 1000                 1005             


Ser Pro  Phe Phe Gly Asp Glu  Ser Asn Lys Pro Ile  Leu Leu Pro 
    1010                 1015                 1020             


Asn Glu  Ser Gln Ser Phe Glu  Arg Ser Val Gln Leu  Leu Asp Gln 
    1025                 1030                 1035             


Ile Pro  Ser Tyr Asp Thr His  Lys Ile Ala Val Leu  Tyr Val Gly 
    1040                 1045                 1050             


Glu Gly  Gln Ser Asn Ser Glu  Leu Ala Ile Leu Ser  Asn Glu His 
    1055                 1060                 1065             


Gly Ser  Tyr Arg Tyr Thr Glu  Phe Leu Thr Gly Leu  Gly Arg Leu 
    1070                 1075                 1080             


Ile Glu  Leu Lys Asp Cys Gln  Pro Asp Lys Val Tyr  Leu Gly Gly 
    1085                 1090                 1095             


Leu Asp  Val Cys Gly Glu Asp  Gly Gln Phe Thr Tyr  Cys Trp His 
    1100                 1105                 1110             


Asp Asp  Ile Met Gln Ala Val  Phe His Ile Ala Thr  Leu Met Pro 
    1115                 1120                 1125             


Thr Lys  Asp Val Asp Lys His  Arg Cys Asp Lys Lys  Arg His Leu 
    1130                 1135                 1140             


Gly Asn  Asp Phe Val Ser Ile  Val Tyr Asn Asp Ser  Gly Glu Asp 
    1145                 1150                 1155             


Phe Lys  Leu Gly Thr Ile Lys  Gly Gln Phe Asn Phe  Val His Val 
    1160                 1165                 1170             


Ile Val  Thr Pro Leu Asp Tyr  Glu Cys Asn Leu Val  Ser Leu Gln 
    1175                 1180                 1185             


Cys Arg  Lys Asp Met Glu Gly  Leu Val Asp Thr Ser  Val Ala Lys 
    1190                 1195                 1200             


Ile Val  Ser Asp Arg Asn Leu  Pro Phe Val Ala Arg  Gln Met Ala 
    1205                 1210                 1215             


Leu His  Ala Asn Met Ala Ser  Gln Val His His Ser  Arg Ser Asn 
    1220                 1225                 1230             


Pro Thr  Asp Ile Tyr Pro Ser  Lys Trp Ile Ala Arg  Leu Arg His 
    1235                 1240                 1245             


Ile Lys  Arg Leu Arg Gln Arg  Ile Cys Glu Glu Ala  Ala Tyr Ser 
    1250                 1255                 1260             


Asn Pro  Ser Leu Pro Leu Val  His Pro Pro Ser His  Ser Lys Ala 
    1265                 1270                 1275             


Pro Ala  Gln Thr Pro Ala Glu  Pro Thr Pro Gly Tyr  Glu Val Gly 
    1280                 1285                 1290             


Gln Arg  Lys Arg Leu Ile Ser  Ser Val Glu Asp Phe  Thr Glu Phe 
    1295                 1300                 1305             


Val 
    


<210>  17
<211>  1267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  17

Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
1               5                   10                  15      


Ile Leu Leu Gly Leu Gly Thr Pro Arg Pro Asn Pro Arg Ser Ala Glu 
            20                  25                  30          


Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
        35                  40                  45              


Ser Met Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
    50                  55                  60                  


Cys Glu Val Ala Lys Thr Lys Lys Phe Glu Glu His Ala Val Glu Ala 
65                  70                  75                  80  


Leu Trp Lys Ala Val Ala Asp Leu Leu Gln Pro Glu Arg Pro Leu Glu 
                85                  90                  95      


Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
            100                 105                 110         


Gly Glu Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
        115                 120                 125             


Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
    130                 135                 140                 


Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
145                 150                 155                 160 


Ala Asp Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                165                 170                 175     


Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
            180                 185                 190         


Glu Tyr Ile Ala Arg Met Val Gln Met Ile Cys Leu Leu Cys Val Arg 
        195                 200                 205             


Thr Ala Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
    210                 215                 220                 


Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
225                 230                 235                 240 


Val Thr Leu Cys Arg Thr Ile Asn Val Lys Glu Leu Cys Glu Pro Cys 
                245                 250                 255     


Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
            260                 265                 270         


Ile Tyr Asn Met Cys His Leu Met Glu Asp Arg Ala Tyr Met Glu Asp 
        275                 280                 285             


Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
    290                 295                 300                 


Gly Ala His Arg Leu Tyr Ser Leu Arg Asn Ser Pro Thr Ser Val Leu 
305                 310                 315                 320 


Pro Ser Phe Tyr Gln Ala Met Ala Cys Pro Asn Glu Val Val Ser Tyr 
                325                 330                 335     


Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
            340                 345                 350         


Leu Gln Val Val Ala Trp Asp Ile Leu Leu Asn Ile Ile Glu Arg Leu 
        355                 360                 365             


Leu Gln Gln Leu Gln Thr Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
    370                 375                 380                 


His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
385                 390                 395                 400 


His Gly Ser Gln Glu Arg Tyr Phe Glu Leu Val Glu Arg Cys Ala Asp 
                405                 410                 415     


Gln Arg Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro Lys Ser 
        435                 440                 445             


Ser Arg Ile Gln Thr Ser Leu Thr Ser Ala Ser Leu Gly Ser Ala Asp 
    450                 455                 460                 


Glu Asn Ser Val Ala Gln Ala Asp Asp Ser Leu Lys Asn Leu His Leu 
465                 470                 475                 480 


Glu Leu Thr Glu Thr Cys Leu Asp Met Met Ala Arg Tyr Val Phe Ser 
                485                 490                 495     


Asn Phe Thr Ala Val Pro Lys Arg Ser Pro Val Gly Glu Phe Leu Leu 
            500                 505                 510         


Ala Gly Gly Arg Thr Lys Thr Trp Leu Val Gly Asn Lys Leu Val Thr 
        515                 520                 525             


Val Thr Thr Ser Val Gly Thr Gly Thr Arg Ser Leu Leu Gly Leu Asp 
    530                 535                 540                 


Ser Gly Glu Leu Gln Ser Gly Pro Glu Ser Ser Ser Ser Pro Gly Val 
545                 550                 555                 560 


His Val Arg Gln Thr Lys Glu Ala Pro Ala Lys Leu Glu Ser Gln Ala 
                565                 570                 575     


Gly Gln Gln Val Ser Arg Gly Ala Arg Asp Arg Val Arg Ser Met Ser 
            580                 585                 590         


Gly Gly His Gly Leu Arg Val Gly Ala Leu Asp Val Pro Ala Ser Gln 
        595                 600                 605             


Phe Leu Gly Ser Ala Thr Ser Pro Gly Pro Arg Thr Ala Pro Ala Ala 
    610                 615                 620                 


Lys Pro Glu Lys Ala Ser Ala Gly Thr Arg Val Pro Val Gln Glu Lys 
625                 630                 635                 640 


Thr Asn Leu Ala Ala Tyr Val Pro Leu Leu Thr Gln Gly Trp Ala Glu 
                645                 650                 655     


Ile Leu Val Arg Arg Pro Thr Gly Asn Thr Ser Trp Leu Met Ser Leu 
            660                 665                 670         


Glu Asn Pro Leu Ser Pro Phe Ser Ser Asp Ile Asn Asn Met Pro Leu 
        675                 680                 685             


Gln Glu Leu Ser Asn Ala Leu Met Ala Ala Glu Arg Phe Lys Glu His 
    690                 695                 700                 


Arg Asp Thr Ala Leu Tyr Lys Ser Leu Ser Val Pro Ala Ala Ser Thr 
705                 710                 715                 720 


Ala Lys Pro Pro Pro Leu Pro Arg Ser Asn Thr Val Ala Ser Phe Ser 
                725                 730                 735     


Ser Leu Tyr Gln Ser Ser Cys Gln Gly Gln Leu His Arg Ser Val Ser 
            740                 745                 750         


Trp Ala Asp Ser Ala Val Val Met Glu Glu Gly Ser Pro Gly Glu Val 
        755                 760                 765             


Pro Val Leu Val Glu Pro Pro Gly Leu Glu Asp Val Glu Ala Ala Leu 
    770                 775                 780                 


Gly Met Asp Arg Arg Thr Asp Ala Tyr Ser Arg Ser Ser Ser Val Ser 
785                 790                 795                 800 


Ser Gln Glu Glu Lys Ser Leu His Ala Glu Glu Leu Val Gly Arg Gly 
                805                 810                 815     


Ile Pro Ile Glu Arg Val Val Ser Ser Glu Gly Gly Arg Pro Ser Val 
            820                 825                 830         


Asp Leu Ser Phe Gln Pro Ser Gln Pro Leu Ser Lys Ser Ser Ser Ser 
        835                 840                 845             


Pro Glu Leu Gln Thr Leu Gln Asp Ile Leu Gly Asp Pro Gly Asp Lys 
    850                 855                 860                 


Ala Asp Val Gly Arg Leu Ser Pro Glu Val Lys Ala Arg Ser Gln Ser 
865                 870                 875                 880 


Gly Thr Leu Asp Gly Glu Ser Ala Ala Trp Ser Ala Ser Gly Glu Asp 
                885                 890                 895     


Ser Arg Gly Gln Pro Glu Gly Pro Leu Pro Ser Ser Ser Pro Arg Ser 
            900                 905                 910         


Pro Ser Gly Leu Arg Pro Arg Gly Tyr Thr Ile Ser Asp Ser Ala Pro 
        915                 920                 925             


Ser Arg Arg Gly Lys Arg Val Glu Arg Asp Ala Leu Lys Ser Arg Ala 
    930                 935                 940                 


Thr Ala Ser Asn Ala Glu Lys Val Pro Gly Ile Asn Pro Ser Phe Val 
945                 950                 955                 960 


Phe Leu Gln Leu Tyr His Ser Pro Phe Phe Gly Asp Glu Ser Asn Lys 
                965                 970                 975     


Pro Ile Leu Leu Pro Asn Glu Ser Gln Ser Phe Glu Arg Ser Val Gln 
            980                 985                 990         


Leu Leu Asp Gln Ile Pro Ser Tyr  Asp Thr His Lys Ile  Ala Val Leu 
        995                 1000                 1005             


Tyr Val  Gly Glu Gly Gln Ser  Asn Ser Glu Leu Ala  Ile Leu Ser 
    1010                 1015                 1020             


Asn Glu  His Gly Ser Tyr Arg  Tyr Thr Glu Phe Leu  Thr Gly Leu 
    1025                 1030                 1035             


Gly Arg  Leu Ile Glu Leu Lys  Asp Cys Gln Pro Asp  Lys Val Tyr 
    1040                 1045                 1050             


Leu Gly  Gly Leu Asp Val Cys  Gly Glu Asp Gly Gln  Phe Thr Tyr 
    1055                 1060                 1065             


Cys Trp  His Asp Asp Ile Met  Gln Ala Val Phe His  Ile Ala Thr 
    1070                 1075                 1080             


Leu Met  Pro Thr Lys Asp Val  Asp Lys His Arg Cys  Asp Lys Lys 
    1085                 1090                 1095             


Arg His  Leu Gly Asn Asp Phe  Val Ser Ile Val Tyr  Asn Asp Ser 
    1100                 1105                 1110             


Gly Glu  Asp Phe Lys Leu Gly  Thr Ile Lys Gly Gln  Phe Asn Phe 
    1115                 1120                 1125             


Val His  Val Ile Val Thr Pro  Leu Asp Tyr Glu Cys  Asn Leu Val 
    1130                 1135                 1140             


Ser Leu  Gln Cys Arg Lys Asp  Met Glu Gly Leu Val  Asp Thr Ser 
    1145                 1150                 1155             


Val Ala  Lys Ile Val Ser Asp  Arg Asn Leu Pro Phe  Val Ala Arg 
    1160                 1165                 1170             


Gln Met  Ala Leu His Ala Asn  Met Ala Ser Gln Val  His His Ser 
    1175                 1180                 1185             


Arg Ser  Asn Pro Thr Asp Ile  Tyr Pro Ser Lys Trp  Ile Ala Arg 
    1190                 1195                 1200             


Leu Arg  His Ile Lys Arg Leu  Arg Gln Arg Ile Cys  Glu Glu Ala 
    1205                 1210                 1215             


Ala Tyr  Ser Asn Pro Ser Leu  Pro Leu Val His Pro  Pro Ser His 
    1220                 1225                 1230             


Ser Lys  Ala Pro Ala Gln Thr  Pro Ala Glu Pro Thr  Pro Gly Tyr 
    1235                 1240                 1245             


Glu Val  Gly Gln Arg Lys Arg  Leu Ile Ser Ser Val  Glu Asp Phe 
    1250                 1255                 1260             


Thr Glu  Phe Val 
    1265         


<210>  18
<211>  1200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  18

Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
1               5                   10                  15      


Ile Leu Leu Gly Leu Gly Thr Pro Arg Pro Asn Pro Arg Ser Ala Glu 
            20                  25                  30          


Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
        35                  40                  45              


Ser Met Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
    50                  55                  60                  


Cys Glu Val Ala Lys Thr Lys Lys Phe Glu Glu His Ala Val Glu Ala 
65                  70                  75                  80  


Leu Trp Lys Ala Val Ala Asp Leu Leu Gln Pro Glu Arg Pro Leu Glu 
                85                  90                  95      


Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
            100                 105                 110         


Gly Glu Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
        115                 120                 125             


Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
    130                 135                 140                 


Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
145                 150                 155                 160 


Ala Asp Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                165                 170                 175     


Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
            180                 185                 190         


Glu Tyr Ile Ala Arg Met Val Gln Met Ile Cys Leu Leu Cys Val Arg 
        195                 200                 205             


Thr Ala Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
    210                 215                 220                 


Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
225                 230                 235                 240 


Val Thr Leu Cys Arg Thr Ile Asn Val Lys Glu Leu Cys Glu Pro Cys 
                245                 250                 255     


Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
            260                 265                 270         


Ile Tyr Asn Met Cys His Leu Met Glu Asp Arg Ala Tyr Met Glu Asp 
        275                 280                 285             


Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
    290                 295                 300                 


Gly Ala His Arg Leu Tyr Ser Leu Arg Asn Ser Pro Thr Ser Val Leu 
305                 310                 315                 320 


Pro Ser Phe Tyr Gln Ala Met Ala Cys Pro Asn Glu Val Val Ser Tyr 
                325                 330                 335     


Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
            340                 345                 350         


Leu Gln Val Val Ala Trp Asp Ile Leu Leu Asn Ile Ile Glu Arg Leu 
        355                 360                 365             


Leu Gln Gln Leu Gln Thr Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
    370                 375                 380                 


His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
385                 390                 395                 400 


His Gly Ser Gln Glu Arg Tyr Phe Glu Leu Val Glu Arg Cys Ala Asp 
                405                 410                 415     


Gln Arg Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro Lys Ser 
        435                 440                 445             


Ser Arg Ile Gln Thr Ser Leu Thr Ser Ala Ser Leu Gly Ser Ala Asp 
    450                 455                 460                 


Glu Asn Ser Val Ala Gln Ala Asp Asp Ser Leu Lys Asn Leu His Leu 
465                 470                 475                 480 


Glu Leu Thr Glu Thr Cys Leu Asp Met Met Ala Arg Tyr Val Phe Ser 
                485                 490                 495     


Asn Phe Thr Ala Val Pro Lys Arg Ser Pro Val Gly Glu Phe Leu Leu 
            500                 505                 510         


Ala Gly Gly Arg Thr Lys Thr Trp Leu Val Gly Asn Lys Leu Val Thr 
        515                 520                 525             


Val Thr Thr Ser Val Gly Thr Gly Thr Arg Ser Leu Leu Gly Leu Asp 
    530                 535                 540                 


Ser Gly Glu Leu Gln Ser Gly Pro Glu Ser Ser Ser Ser Pro Gly Val 
545                 550                 555                 560 


His Val Arg Gln Thr Lys Glu Ala Pro Ala Lys Leu Glu Ser Gln Ala 
                565                 570                 575     


Gly Gln Gln Val Ser Arg Gly Ala Arg Asp Arg Val Arg Ser Met Ser 
            580                 585                 590         


Gly Gly His Gly Leu Arg Val Gly Ala Leu Asp Val Pro Ala Ser Gln 
        595                 600                 605             


Phe Leu Gly Ser Ala Thr Ser Pro Gly Pro Arg Thr Ala Pro Ala Ala 
    610                 615                 620                 


Lys Pro Glu Lys Ala Ser Ala Gly Thr Arg Val Pro Val Gln Glu Lys 
625                 630                 635                 640 


Thr Asn Leu Ala Ala Tyr Val Pro Leu Leu Thr Gln Gly Trp Ala Glu 
                645                 650                 655     


Ile Leu Val Arg Arg Pro Thr Gly Val Ala Ser Phe Ser Ser Leu Tyr 
            660                 665                 670         


Gln Ser Ser Cys Gln Gly Gln Leu His Arg Ser Val Ser Trp Ala Asp 
        675                 680                 685             


Ser Ala Val Val Met Glu Glu Gly Ser Pro Gly Glu Val Pro Val Leu 
    690                 695                 700                 


Val Glu Pro Pro Gly Leu Glu Asp Val Glu Ala Ala Leu Gly Met Asp 
705                 710                 715                 720 


Arg Arg Thr Asp Ala Tyr Ser Arg Ser Ser Ser Val Ser Ser Gln Glu 
                725                 730                 735     


Glu Lys Ser Leu His Ala Glu Glu Leu Val Gly Arg Gly Ile Pro Ile 
            740                 745                 750         


Glu Arg Val Val Ser Ser Glu Gly Gly Arg Pro Ser Val Asp Leu Ser 
        755                 760                 765             


Phe Gln Pro Ser Gln Pro Leu Ser Lys Ser Ser Ser Ser Pro Glu Leu 
    770                 775                 780                 


Gln Thr Leu Gln Asp Ile Leu Gly Asp Pro Gly Asp Lys Ala Asp Val 
785                 790                 795                 800 


Gly Arg Leu Ser Pro Glu Val Lys Ala Arg Ser Gln Ser Gly Thr Leu 
                805                 810                 815     


Asp Gly Glu Ser Ala Ala Trp Ser Ala Ser Gly Glu Asp Ser Arg Gly 
            820                 825                 830         


Gln Pro Glu Gly Pro Leu Pro Ser Ser Ser Pro Arg Ser Pro Ser Gly 
        835                 840                 845             


Leu Arg Pro Arg Gly Tyr Thr Ile Ser Asp Ser Ala Pro Ser Arg Arg 
    850                 855                 860                 


Gly Lys Arg Val Glu Arg Asp Ala Leu Lys Ser Arg Ala Thr Ala Ser 
865                 870                 875                 880 


Asn Ala Glu Lys Val Pro Gly Ile Asn Pro Ser Phe Val Phe Leu Gln 
                885                 890                 895     


Leu Tyr His Ser Pro Phe Phe Gly Asp Glu Ser Asn Lys Pro Ile Leu 
            900                 905                 910         


Leu Pro Asn Glu Ser Gln Ser Phe Glu Arg Ser Val Gln Leu Leu Asp 
        915                 920                 925             


Gln Ile Pro Ser Tyr Asp Thr His Lys Ile Ala Val Leu Tyr Val Gly 
    930                 935                 940                 


Glu Gly Gln Ser Asn Ser Glu Leu Ala Ile Leu Ser Asn Glu His Gly 
945                 950                 955                 960 


Ser Tyr Arg Tyr Thr Glu Phe Leu Thr Gly Leu Gly Arg Leu Ile Glu 
                965                 970                 975     


Leu Lys Asp Cys Gln Pro Asp Lys Val Tyr Leu Gly Gly Leu Asp Val 
            980                 985                 990         


Cys Gly Glu Asp Gly Gln Phe Thr  Tyr Cys Trp His Asp  Asp Ile Met 
        995                 1000                 1005             


Gln Ala  Val Phe His Ile Ala  Thr Leu Met Pro Thr  Lys Asp Val 
    1010                 1015                 1020             


Asp Lys  His Arg Cys Asp Lys  Lys Arg His Leu Gly  Asn Asp Phe 
    1025                 1030                 1035             


Val Ser  Ile Val Tyr Asn Asp  Ser Gly Glu Asp Phe  Lys Leu Gly 
    1040                 1045                 1050             


Thr Ile  Lys Gly Gln Phe Asn  Phe Val His Val Ile  Val Thr Pro 
    1055                 1060                 1065             


Leu Asp  Tyr Glu Cys Asn Leu  Val Ser Leu Gln Cys  Arg Lys Asp 
    1070                 1075                 1080             


Met Glu  Gly Leu Val Asp Thr  Ser Val Ala Lys Ile  Val Ser Asp 
    1085                 1090                 1095             


Arg Asn  Leu Pro Phe Val Ala  Arg Gln Met Ala Leu  His Ala Asn 
    1100                 1105                 1110             


Met Ala  Ser Gln Val His His  Ser Arg Ser Asn Pro  Thr Asp Ile 
    1115                 1120                 1125             


Tyr Pro  Ser Lys Trp Ile Ala  Arg Leu Arg His Ile  Lys Arg Leu 
    1130                 1135                 1140             


Arg Gln  Arg Ile Cys Glu Glu  Ala Ala Tyr Ser Asn  Pro Ser Leu 
    1145                 1150                 1155             


Pro Leu  Val His Pro Pro Ser  His Ser Lys Ala Pro  Ala Gln Thr 
    1160                 1165                 1170             


Pro Ala  Glu Pro Thr Pro Gly  Tyr Glu Val Gly Gln  Arg Lys Arg 
    1175                 1180                 1185             


Leu Ile  Ser Ser Val Glu Asp  Phe Thr Glu Phe Val  
    1190                 1195                 1200 


<210>  19
<211>  1038
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  19

Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
1               5                   10                  15      


Ile Leu Leu Gly Leu Gly Thr Pro Arg Pro Asn Pro Arg Ser Ala Glu 
            20                  25                  30          


Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
        35                  40                  45              


Ser Met Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
    50                  55                  60                  


Cys Glu Val Ala Lys Thr Lys Lys Phe Glu Glu His Ala Val Glu Ala 
65                  70                  75                  80  


Leu Trp Lys Ala Val Ala Asp Leu Leu Gln Pro Glu Arg Pro Leu Glu 
                85                  90                  95      


Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
            100                 105                 110         


Gly Glu Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
        115                 120                 125             


Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
    130                 135                 140                 


Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
145                 150                 155                 160 


Ala Asp Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                165                 170                 175     


Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
            180                 185                 190         


Glu Tyr Ile Ala Arg Met Val Gln Met Ile Cys Leu Leu Cys Val Arg 
        195                 200                 205             


Thr Ala Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
    210                 215                 220                 


Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
225                 230                 235                 240 


Val Thr Leu Cys Arg Thr Ile Asn Val Lys Glu Leu Cys Glu Pro Cys 
                245                 250                 255     


Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
            260                 265                 270         


Ile Tyr Asn Met Cys His Leu Met Glu Asp Arg Ala Tyr Met Glu Asp 
        275                 280                 285             


Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
    290                 295                 300                 


Gly Ala His Arg Leu Tyr Ser Leu Arg Asn Ser Pro Thr Ser Val Leu 
305                 310                 315                 320 


Pro Ser Phe Tyr Gln Ala Met Ala Cys Pro Asn Glu Val Val Ser Tyr 
                325                 330                 335     


Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
            340                 345                 350         


Leu Gln Val Val Ala Trp Asp Ile Leu Leu Asn Ile Ile Glu Arg Leu 
        355                 360                 365             


Leu Gln Gln Leu Gln Thr Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
    370                 375                 380                 


His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
385                 390                 395                 400 


His Gly Ser Gln Glu Arg Tyr Phe Glu Leu Val Glu Arg Cys Ala Asp 
                405                 410                 415     


Gln Arg Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro Lys Ser 
        435                 440                 445             


Ser Arg Ile Gln Thr Ser Leu Thr Ser Ala Ser Leu Gly Ser Ala Asp 
    450                 455                 460                 


Glu Asn Ser Val Ala Gln Ala Asp Asp Ser Leu Lys Asn Leu His Leu 
465                 470                 475                 480 


Glu Leu Thr Glu Thr Cys Leu Asp Met Met Ala Arg Tyr Val Phe Ser 
                485                 490                 495     


Asn Phe Thr Ala Val Pro Lys Arg Ser Pro Val Gly Glu Phe Leu Leu 
            500                 505                 510         


Ala Gly Gly Arg Thr Lys Thr Trp Leu Val Gly Asn Lys Leu Val Thr 
        515                 520                 525             


Val Thr Thr Ser Val Gly Thr Gly Thr Arg Ser Leu Leu Gly Leu Asp 
    530                 535                 540                 


Ser Gly Glu Leu Gln Ser Gly Pro Glu Ser Ser Ser Ser Pro Gly Val 
545                 550                 555                 560 


His Val Arg Gln Thr Lys Glu Ala Pro Ala Lys Leu Glu Ser Gln Ala 
                565                 570                 575     


Gly Gln Gln Val Ser Arg Gly Ala Arg Asp Arg Val Arg Ser Met Ser 
            580                 585                 590         


Gly Gly His Gly Leu Arg Val Gly Ala Leu Asp Val Pro Ala Ser Gln 
        595                 600                 605             


Phe Leu Gly Ser Ala Thr Ser Pro Gly Pro Arg Thr Ala Pro Ala Ala 
    610                 615                 620                 


Lys Pro Glu Lys Ala Ser Ala Gly Thr Arg Val Pro Val Gln Glu Lys 
625                 630                 635                 640 


Thr Asn Leu Ala Ala Tyr Val Pro Leu Leu Thr Gln Gly Trp Ala Glu 
                645                 650                 655     


Ile Leu Val Arg Arg Pro Thr Gly Val Ala Ser Phe Ser Ser Leu Tyr 
            660                 665                 670         


Gln Ser Ser Cys Gln Gly Gln Leu His Arg Ser Val Ser Trp Ala Asp 
        675                 680                 685             


Ser Ala Val Val Met Glu Glu Gly Ser Pro Gly Glu Val Pro Val Leu 
    690                 695                 700                 


Val Glu Pro Pro Gly Leu Glu Asp Val Glu Ala Ala Leu Gly Met Asp 
705                 710                 715                 720 


Arg Arg Thr Asp Ala Tyr Ser Arg Ser Phe Val Phe Leu Gln Leu Tyr 
                725                 730                 735     


His Ser Pro Phe Phe Gly Asp Glu Ser Asn Lys Pro Ile Leu Leu Pro 
            740                 745                 750         


Asn Glu Ser Gln Ser Phe Glu Arg Ser Val Gln Leu Leu Asp Gln Ile 
        755                 760                 765             


Pro Ser Tyr Asp Thr His Lys Ile Ala Val Leu Tyr Val Gly Glu Gly 
    770                 775                 780                 


Gln Ser Asn Ser Glu Leu Ala Ile Leu Ser Asn Glu His Gly Ser Tyr 
785                 790                 795                 800 


Arg Tyr Thr Glu Phe Leu Thr Gly Leu Gly Arg Leu Ile Glu Leu Lys 
                805                 810                 815     


Asp Cys Gln Pro Asp Lys Val Tyr Leu Gly Gly Leu Asp Val Cys Gly 
            820                 825                 830         


Glu Asp Gly Gln Phe Thr Tyr Cys Trp His Asp Asp Ile Met Gln Ala 
        835                 840                 845             


Val Phe His Ile Ala Thr Leu Met Pro Thr Lys Asp Val Asp Lys His 
    850                 855                 860                 


Arg Cys Asp Lys Lys Arg His Leu Gly Asn Asp Phe Val Ser Ile Val 
865                 870                 875                 880 


Tyr Asn Asp Ser Gly Glu Asp Phe Lys Leu Gly Thr Ile Lys Gly Gln 
                885                 890                 895     


Phe Asn Phe Val His Val Ile Val Thr Pro Leu Asp Tyr Glu Cys Asn 
            900                 905                 910         


Leu Val Ser Leu Gln Cys Arg Lys Asp Met Glu Gly Leu Val Asp Thr 
        915                 920                 925             


Ser Val Ala Lys Ile Val Ser Asp Arg Asn Leu Pro Phe Val Ala Arg 
    930                 935                 940                 


Gln Met Ala Leu His Ala Asn Met Ala Ser Gln Val His His Ser Arg 
945                 950                 955                 960 


Ser Asn Pro Thr Asp Ile Tyr Pro Ser Lys Trp Ile Ala Arg Leu Arg 
                965                 970                 975     


His Ile Lys Arg Leu Arg Gln Arg Ile Cys Glu Glu Ala Ala Tyr Ser 
            980                 985                 990         


Asn Pro Ser Leu Pro Leu Val His  Pro Pro Ser His Ser  Lys Ala Pro 
        995                 1000                 1005             


Ala Gln  Thr Pro Ala Glu Pro  Thr Pro Gly Tyr Glu  Val Gly Gln 
    1010                 1015                 1020             


Arg Lys  Arg Leu Ile Ser Ser  Val Glu Asp Phe Thr  Glu Phe Val 
    1025                 1030                 1035             


<210>  20
<211>  2306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  20
gctagcacta gtaccatggc gaaaccgacc agcaaagata gcggcctgaa agaaaaattt       60

aaaattctgc tgggcctggg caccccgcgc ccgaacccgc gcagcgcgga aggcaaacag      120

accgaattta ttattaccgc ggaaattctg cgcgaactga gcatggaatg cggcctgaac      180

aaccgcattc gcatgattgg ccagatttgc gaagtggcga aaaccaaaaa atttgaagaa      240

catgcggtgg aagcgctgtg gaaagcggtg gcggatctgc tgcagccgga acgcccgctg      300

gaagcgcgcc atgcggtgct ggcgctgctg aaagcgattg tgcagggcca gggcgaacgc      360

ctgggcgtgc tgcgcgcgct gttttttaaa gtgattaaag attatccgag caacgaagat      420

ctgcatgaac gcctggaagt gtttaaagcg ctgaccgata acggccgcca tattacctat      480

ctggaagaag aactggcgga ttttgtgctg cagtggatgg atgtgggcct gagcagcgaa      540

tttctgctgg tgctggtgaa cctggtgaaa tttaacagct gctatctgga tgaatatatt      600

gcgcgcatgg tgcagatgat ttgcctgctg tgcgtgcgca ccgcgagcag cgtggatatt      660

gaagtgagcc tgcaggtgct ggatgcggtg gtgtgctata actgcctgcc ggcggaaagc      720

ctgccgctgt ttattgtgac cctgtgccgc accattaacg tgaaagaact gtgcgaaccg      780

tgctggaaac tgatgcgcaa cctgctgggc acccatctgg gccatagcgc gatttataac      840

atgtgccatc tgatggaaga tcgcgcgtat atggaagatg cgccgctgct gcgcggcgcg      900

gtgttttttg tgggcatggc gctgtggggc gcgcatcgcc tgtatagcct gcgcaacagc      960

ccgaccagcg tgctgccgag cttttatcag gcgatggcgt gcccgaacga agtggtgagc     1020

tatgaaattg tgctgagcat tacccgcctg attaaaaaat atcgcaaaga actgcaggtg     1080

gtggcgtggg atattctgct gaacattatt gaacgcctgc tgcagcagct gcagaccctg     1140

gatagcccgg aactgcgcac cattgtgcat gatctgctga ccaccgtgga agaactgtgc     1200

gatcagaacg aatttcatgg cagccaggaa cgctattttg aactggtgga acgctgcgcg     1260

gatcagcgcc cggaaagcag cctgctgaac ctgattagct atcgcgcgca gagcattcat     1320

ccggcgaaag atggctggat tcagaacctg caggcgctga tggaatctgg tgggggtagc     1380

ggaggagggt cagggggcgg cagtggaggc ggaaaaccga ttctgctgcc gaacgaaagc     1440

cagagctttg aacgcagcgt gcagctgctg gatcagattc cgagctatga tacccataaa     1500

attgcggtgc tgtatgtggg cgaaggccag agcaacagcg aactggcgat tctgagcaac     1560

gaacatggca gctatcgcta taccgaattt ctgaccggcc tgggccgcct gattgaactg     1620

aaagattgcc agccggataa agtgtatctg ggcggcctgg atgtgtgcgg cgaagatggc     1680

cagtttacct attgctggca tgatgatatt atgcaggcgg tgtttcatat tgcgaccctg     1740

atgccgacca aagatgtgga taaacatcgc tgcgataaaa aacgccatct gggcaacgat     1800

tttgtgagca ttgtgtataa cgatagcggc gaagatttta aactgggcac cattaaaggc     1860

cagtttaact ttgtgcatgt gattgtgacc ccgctggatt atgaatgcaa cctggtgagc     1920

ctgcagtgcc gcaaagatat ggaaggcctg gtggatacca gcgtggcgaa aattgtgagc     1980

gatcgcaacc tgccgtttgt ggcgcgccag atggcgctgc atgcgaacat ggcgagccag     2040

gtgcatcata gccgcagcaa cccgaccgat atttatccga gcaaatggat tgcgcgcctg     2100

cgccatatta aacgcctgcg ccagcgcatt tgcgaagaag cggcgtatag caacccgagc     2160

ctgccgctgg tgcatccgcc gagccatagc aaagcgccgg cgcagacccc ggcggaaccg     2220

accccgggct atgaagtggg ccagcgcaaa cgcctgatta gcagcgtgga agattttacc     2280

gaatttgtgt aggcggccgc ctcgag                                          2306


<210>  21
<211>  3402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  21
atggcaaaac ctacatcaaa agatagcgga ctgaaagaga agttcaaaat cctgctggga       60

ctggggacac cacgccctaa tccacggtcc gccgagggca agcagaccga gttcatcatc      120

acagccgaga tcctgcgcga gctgtctatg gagtgcggcc tgaacaatcg gatcagaatg      180

atcggccaga tttgcgaggt ggccaagacc aagaagtttg aggagcacgc agtggaggcc      240

ctgtggaagg cagtggccga tctgctgcag cctgagagac cactggaggc aaggcacgcc      300

gtgctggccc tgctgaaggc catcgtgcag ggacagggag agcgcctggg cgtgctgcgg      360

gccctgttct ttaaagtgat caaggactac cctagcaacg aggatctgca cgagagactg      420

gaggtgttca aggccctgac cgataatggc aggcacatca catatctgga ggaggagctg      480

gccgactttg tgctgcagtg gatggatgtg ggcctgagct ccgagttcct gctggtgctg      540

gtgaacctgg tgaagtttaa ttcctgctac ctggacgagt atatcgcccg catggtgcag      600

atgatctgcc tgctgtgcgt gcggaccgcc tctagcgtgg acatcgaggt gtctctgcag      660

gtgctggatg ccgtggtgtg ctacaactgt ctgcccgccg agagcctgcc tctgttcatc      720

gtgaccctgt gcagaacaat caatgtgaag gagctgtgcg agccttgttg gaagctgatg      780

aggaacctgc tgggcacaca cctgggacac agcgccatct acaatatgtg ccacctgatg      840

gaggaccgcg cctatatgga ggatgcacca ctgctgaggg gagccgtgtt ctttgtggga      900

atggcactgt ggggagcaca cagactgtac tccctgagga actctccaac cagcgtgctg      960

ccctcttttt accaggctat ggcctgtcca aatgaggtgg tgtcttatga gatcgtgctg     1020

agcatcacac gcctgatcaa gaagtatcgg aaggagctgc aggtggtggc ctgggacatc     1080

ctgctgaaca tcatcgagcg cctgctgcag cagctgcaga ccctggacag cccagagctg     1140

aggacaatcg tgcacgatct gctgaccaca gtggaggagc tgtgcgacca gaatgagttc     1200

cacggctccc aggagcggta ctttgagctg gtggagcggt gcgcagatca gaggccagag     1260

tcctctctgc tgaacctgat ctcctatcgg gcccagtcta tccaccctgc caaggacggc     1320

tggattcaga atctgcaggc cctgatggag agcggaggag gctccggagg aggctctgga     1380

ggcggcagcg gcggcggcgg cgccctggac gtgccggcct cccagttcct gggcagtgcc     1440

acttctccag gaccacggac tgcaccagcc gcgaaacctg agaaggcctc agctggcacc     1500

cgggttcctg tgcaggagaa gacgaacctg gcggcctatg tgcccctgct gacccagggc     1560

tgggcggaga tcctggtccg gaggcccaca gggaacacca gctggctgat gagcctggag     1620

aacccgctca gccctttctc ctcggacatc aacaacatgc ccctgcagga gctgtctaac     1680

gccctcatgg cggctgagcg cttcaaggag caccgggaca cagccctgta caagtcactg     1740

tcggtgccgg cagccagcac ggccaaaccc cctcctctgc ctcgctccaa cacagtggcc     1800

tctttctcct ccctgtacca gtccagctgc caaggacagc tgcacaggag cgtttcctgg     1860

gcagactccg ccgtggtcat ggaggaggga agtccgggcg aggttcctgt gctggtggag     1920

cccccagggt tggaggacgt tgaggcagcg ctaggcatgg acaggcgcac ggatgcctac     1980

agcaggtcgt cctcagtctc cagccaggag gagaagtcgc tccacgcgga ggagctggtt     2040

ggcaggggca tccccatcga gcgagtcgtc tcctcggagg gtggccggcc ctctgtggac     2100

ctctccttcc agccctcgca gcccctgagc aagtccagct cctctcccga gctgcagact     2160

ctgcaggaca tcctcgggga ccctggggac aaggccgacg tgggccggct gagccctgag     2220

gttaaggccc ggtcacagtc agggaccctg gacggggaaa gtgctgcctg gtcggcctcg     2280

ggcgaagaca gtcggggcca gcccgagggt cccttgcctt ccagctcccc ccgctcgccc     2340

agtggcctcc ggccccgagg ttacaccatc tccgactcgg ccccatcacg caggggcaag     2400

agagtagaga gggacgcctt aaagagcaga gccacagcct ccaatgcaga gaaagtgcca     2460

ggcatcaacc ccagtttcgt gttcctgcag ctctaccatt cccccttctt tggcgacgag     2520

tcaaacaagc caatcctgct gcccaatgag tcacagtcct ttgagcggtc ggtgcagctc     2580

ctcgaccaga tcccatcata cgacacccac aagatcgccg tcctgtatgt tggagaaggc     2640

cagagcaaca gcgagctcgc catcctgtcc aatgagcatg gctcctacag gtacacggag     2700

ttcctgacgg gcctgggccg gctcatcgag ctgaaggact gccagccgga caaggtgtac     2760

ctgggaggcc tggacgtgtg tggtgaggac ggccagttca cctactgctg gcacgatgac     2820

atcatgcaag ccgtcttcca catcgccacc ctgatgccca ccaaggacgt ggacaagcac     2880

cgctgcgaca agaagcgcca cctgggcaac gactttgtgt ccattgtcta caatgactcc     2940

ggtgaggact tcaagcttgg caccatcaag ggccagttca actttgtcca cgtgatcgtc     3000

accccgctgg actacgagtg caacctggtg tccctgcagt gcaggaaaga catggagggc     3060

cttgtggaca ccagcgtggc caagatcgtg tctgaccgca acctgccctt cgtggcccgc     3120

cagatggccc tgcacgcaaa tatggcctca caggtgcatc atagccgctc caaccccacc     3180

gatatctacc cctccaagtg gattgcccgg ctccgccaca tcaagcggct ccgccagcgg     3240

atctgcgagg aagccgccta ctccaacccc agcctacctc tggtgcaccc tccgtcccat     3300

agcaaagccc ctgcacagac tccagccgag cccacacctg gctatgaggt gggccagcgg     3360

aagcgcctca tctcctcggt ggaggacttc accgagtttg tg                        3402


<210>  22
<211>  3306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  22
atggccaaac caacaagcaa agattcaggc ttgaaggaga agtttaagat tctgttggga       60

ctgggaacac cgaggccaaa tcccaggtct gcagagggta aacagacgga gtttatcatc      120

accgcggaaa tactgagaga actgagcatg gaatgtggcc tcaacaatcg catccggatg      180

atagggcaga tttgtgaagt cgcaaaaacc aagaaatttg aagagcacgc agtggaagca      240

ctctggaagg cggtcgcgga tctgttgcag ccggagcggc cgctggaggc ccggcacgcg      300

gtgctggctc tgctgaaggc catcgtgcag gggcagggcg agcgtttggg ggtcctcaga      360

gccctcttct ttaaggtcat caaggattac ccttccaacg aagaccttca cgaaaggctg      420

gaggttttca aggccctcac agacaatggg agacacatca cctacttgga ggaagagctg      480

gctgactttg tcctgcagtg gatggatgtt ggcttgtcct cggaattcct tctggtgctg      540

gtgaacttgg tcaaattcaa tagctgttac ctcgacgagt acatcgcaag gatggttcag      600

atgatctgtc tgctgtgcgt ccggaccgcg tcctctgtgg acatagaggt ctccctgcag      660

gtgctggacg ccgtggtctg ctacaactgc ctgccggctg agagcctccc gctgttcatc      720

gttaccctct gtcgcaccat caacgtcaag gagctctgcg agccttgctg gaagctgatg      780

cggaacctcc ttggcaccca cctgggccac agcgccatct acaacatgtg ccacctcatg      840

gaggacagag cctacatgga ggacgcgccc ctgctgagag gagccgtgtt ttttgtgggc      900

atggctctct ggggagccca ccggctctat tctctcagga actcgccgac atctgtgttg      960

ccatcatttt accaggccat ggcatgtccg aacgaggtgg tgtcctatga gatcgtcctg     1020

tccatcacca ggctcatcaa gaagtatagg aaggagctcc aggtggtggc gtgggacatt     1080

ctgctgaaca tcatcgaacg gctccttcag cagctccaga ccttggacag cccggagctc     1140

aggaccatcg tccatgacct gttgaccacg gtggaggagc tgtgtgacca gaacgagttc     1200

cacgggtctc aggagagata ctttgaactg gtggagagat gtgcggacca gaggagcgga     1260

ggaggctccg gaggaggctc tggaggcggc agcggcggcg gcggcgccct ggacgtgccg     1320

gcctcccagt tcctgggcag tgccacttct ccaggaccac ggactgcacc agccgcgaaa     1380

cctgagaagg cctcagctgg cacccgggtt cctgtgcagg agaagacgaa cctggcggcc     1440

tatgtgcccc tgctgaccca gggctgggcg gagatcctgg tccggaggcc cacagggaac     1500

accagctggc tgatgagcct ggagaacccg ctcagccctt tctcctcgga catcaacaac     1560

atgcccctgc aggagctgtc taacgccctc atggcggctg agcgcttcaa ggagcaccgg     1620

gacacagccc tgtacaagtc actgtcggtg ccggcagcca gcacggccaa accccctcct     1680

ctgcctcgct ccaacacagt ggcctctttc tcctccctgt accagtccag ctgccaagga     1740

cagctgcaca ggagcgtttc ctgggcagac tccgccgtgg tcatggagga gggaagtccg     1800

ggcgaggttc ctgtgctggt ggagccccca gggttggagg acgttgaggc agcgctaggc     1860

atggacaggc gcacggatgc ctacagcagg tcgtcctcag tctccagcca ggaggagaag     1920

tcgctccacg cggaggagct ggttggcagg ggcatcccca tcgagcgagt cgtctcctcg     1980

gagggtggcc ggccctctgt ggacctctcc ttccagccct cgcagcccct gagcaagtcc     2040

agctcctctc ccgagctgca gactctgcag gacatcctcg gggaccctgg ggacaaggcc     2100

gacgtgggcc ggctgagccc tgaggttaag gcccggtcac agtcagggac cctggacggg     2160

gaaagtgctg cctggtcggc ctcgggcgaa gacagtcggg gccagcccga gggtcccttg     2220

ccttccagct ccccccgctc gcccagtggc ctccggcccc gaggttacac catctccgac     2280

tcggccccat cacgcagggg caagagagta gagagggacg ccttaaagag cagagccaca     2340

gcctccaatg cagagaaagt gccaggcatc aaccccagtt tcgtgttcct gcagctctac     2400

cattccccct tctttggcga cgagtcaaac aagccaatcc tgctgcccaa tgagtcacag     2460

tcctttgagc ggtcggtgca gctcctcgac cagatcccat catacgacac ccacaagatc     2520

gccgtcctgt atgttggaga aggccagagc aacagcgagc tcgccatcct gtccaatgag     2580

catggctcct acaggtacac ggagttcctg acgggcctgg gccggctcat cgagctgaag     2640

gactgccagc cggacaaggt gtacctggga ggcctggacg tgtgtggtga ggacggccag     2700

ttcacctact gctggcacga tgacatcatg caagccgtct tccacatcgc caccctgatg     2760

cccaccaagg acgtggacaa gcaccgctgc gacaagaagc gccacctggg caacgacttt     2820

gtgtccattg tctacaatga ctccggtgag gacttcaagc ttggcaccat caagggccag     2880

ttcaactttg tccacgtgat cgtcaccccg ctggactacg agtgcaacct ggtgtccctg     2940

cagtgcagga aagacatgga gggccttgtg gacaccagcg tggccaagat cgtgtctgac     3000

cgcaacctgc ccttcgtggc ccgccagatg gccctgcacg caaatatggc ctcacaggtg     3060

catcatagcc gctccaaccc caccgatatc tacccctcca agtggattgc ccggctccgc     3120

cacatcaagc ggctccgcca gcggatctgc gaggaagccg cctactccaa ccccagccta     3180

cctctggtgc accctccgtc ccatagcaaa gcccctgcac agactccagc cgagcccaca     3240

cctggctatg aggtgggcca gcggaagcgc ctcatctcct cggtggagga cttcaccgag     3300

tttgtg                                                                3306


<210>  23
<211>  3927
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  23
atggccaaac caacaagcaa agattcaggc ttgaaggaga agtttaagat tctgttggga       60

ctgggaacac cgaggccaaa tcccaggtct gcagagggta aacagacgga gtttatcatc      120

accgcggaaa tactgagaga actgagcatg gaatgtggcc tcaacaatcg catccggatg      180

atagggcaga tttgtgaagt cgcaaaaacc aagaaatttg aagagcacgc agtggaagca      240

ctctggaagg cggtcgcgga tctgttgcag ccggagcggc cgctggaggc ccggcacgcg      300

gtgctggctc tgctgaaggc catcgtgcag gggcagggcg agcgtttggg ggtcctcaga      360

gccctcttct ttaaggtcat caaggattac ccttccaacg aagaccttca cgaaaggctg      420

gaggttttca aggccctcac agacaatggg agacacatca cctacttgga ggaagagctg      480

gctgactttg tcctgcagtg gatggatgtt ggcttgtcct cggaattcct tctggtgctg      540

gtgaacttgg tcaaattcaa tagctgttac ctcgacgagt acatcgcaag gatggttcag      600

atgatctgtc tgctgtgcgt ccggaccgcg tcctctgtgg acatagaggt ctccctgcag      660

gtgctggacg ccgtggtctg ctacaactgc ctgccggctg agagcctccc gctgttcatc      720

gttaccctct gtcgcaccat caacgtcaag gagctctgcg agccttgctg gaagctgatg      780

cggaacctcc ttggcaccca cctgggccac agcgccatct acaacatgtg ccacctcatg      840

gaggacagag cctacatgga ggacgcgccc ctgctgagag gagccgtgtt ttttgtgggc      900

atggctctct ggggagccca ccggctctat tctctcagga actcgccgac atctgtgttg      960

ccatcatttt accaggccat ggcatgtccg aacgaggtgg tgtcctatga gatcgtcctg     1020

tccatcacca ggctcatcaa gaagtatagg aaggagctcc aggtggtggc gtgggacatt     1080

ctgctgaaca tcatcgaacg gctccttcag cagctccaga ccttggacag cccggagctc     1140

aggaccatcg tccatgacct gttgaccacg gtggaggagc tgtgtgacca gaacgagttc     1200

cacgggtctc aggagagata ctttgaactg gtggagagat gtgcggacca gaggagcgga     1260

ggaggctccg gaggaggctc tggaggcggc agcggcggcg gcttcagggc ccggagtact     1320

agtctcaacg agagacccaa gagtctgagg atagccagac cccccaaaca aggcttgaat     1380

aactctccac ccgtgaaaga attcaaggag agctctgcag ccgaggcctt ccggtgccgc     1440

agcatcagtg tgtctgaaca tgtggtccgc agcaggatac agacgtccct caccagtgcc     1500

agcttggggt ctgcagatga gaactccgtg gcccaggctg acgatagcct gaaaaacctc     1560

cacctggagc tcacggaaac ctgtctggac atgatggctc gatacgtctt ctccaacttc     1620

acggctgtcc cgaagaggtc tcctgtgggc gagttcctcc tagcgggtgg caggaccaaa     1680

acctggctgg ttgggaacaa gcttgtcact gtgacgacaa gcgtgggaac cgggacccgg     1740

tcgttactag gcctggactc gggggagctg cagtccggcc cggagtcgag ctccagcccc     1800

ggggtgcatg tgagacagac caaggaggcg ccggccaagc tggagtccca ggctgggcag     1860

caggtgtccc gtggggcccg ggatcgggtc cgttccatgt cggggggcca tggtcttcga     1920

gttggcgccc tggacgtgcc ggcctcccag ttcctgggca gtgccacttc tccaggacca     1980

cggactgcac cagccgcgaa acctgagaag gcctcagctg gcacccgggt tcctgtgcag     2040

gagaagacga acctggcggc ctatgtgccc ctgctgaccc agggctgggc ggagatcctg     2100

gtccggaggc ccacagggaa caccagctgg ctgatgagcc tggagaaccc gctcagccct     2160

ttctcctcgg acatcaacaa catgcccctg caggagctgt ctaacgccct catggcggct     2220

gagcgcttca aggagcaccg ggacacagcc ctgtacaagt cactgtcggt gccggcagcc     2280

agcacggcca aaccccctcc tctgcctcgc tccaacacag tggcctcttt ctcctccctg     2340

taccagtcca gctgccaagg acagctgcac aggagcgttt cctgggcaga ctccgccgtg     2400

gtcatggagg agggaagtcc gggcgaggtt cctgtgctgg tggagccccc agggttggag     2460

gacgttgagg cagcgctagg catggacagg cgcacggatg cctacagcag gtcgtcctca     2520

gtctccagcc aggaggagaa gtcgctccac gcggaggagc tggttggcag gggcatcccc     2580

atcgagcgag tcgtctcctc ggagggtggc cggccctctg tggacctctc cttccagccc     2640

tcgcagcccc tgagcaagtc cagctcctct cccgagctgc agactctgca ggacatcctc     2700

ggggaccctg gggacaaggc cgacgtgggc cggctgagcc ctgaggttaa ggcccggtca     2760

cagtcaggga ccctggacgg ggaaagtgct gcctggtcgg cctcgggcga agacagtcgg     2820

ggccagcccg agggtccctt gccttccagc tccccccgct cgcccagtgg cctccggccc     2880

cgaggttaca ccatctccga ctcggcccca tcacgcaggg gcaagagagt agagagggac     2940

gccttaaaga gcagagccac agcctccaat gcagagaaag tgccaggcat caaccccagt     3000

ttcgtgttcc tgcagctcta ccattccccc ttctttggcg acgagtcaaa caagccaatc     3060

ctgctgccca atgagtcaca gtcctttgag cggtcggtgc agctcctcga ccagatccca     3120

tcatacgaca cccacaagat cgccgtcctg tatgttggag aaggccagag caacagcgag     3180

ctcgccatcc tgtccaatga gcatggctcc tacaggtaca cggagttcct gacgggcctg     3240

ggccggctca tcgagctgaa ggactgccag ccggacaagg tgtacctggg aggcctggac     3300

gtgtgtggtg aggacggcca gttcacctac tgctggcacg atgacatcat gcaagccgtc     3360

ttccacatcg ccaccctgat gcccaccaag gacgtggaca agcaccgctg cgacaagaag     3420

cgccacctgg gcaacgactt tgtgtccatt gtctacaatg actccggtga ggacttcaag     3480

cttggcacca tcaagggcca gttcaacttt gtccacgtga tcgtcacccc gctggactac     3540

gagtgcaacc tggtgtccct gcagtgcagg aaagacatgg agggccttgt ggacaccagc     3600

gtggccaaga tcgtgtctga ccgcaacctg cccttcgtgg cccgccagat ggccctgcac     3660

gcaaatatgg cctcacaggt gcatcatagc cgctccaacc ccaccgatat ctacccctcc     3720

aagtggattg cccggctccg ccacatcaag cggctccgcc agcggatctg cgaggaagcc     3780

gcctactcca accccagcct acctctggtg caccctccgt cccatagcaa agcccctgca     3840

cagactccag ccgagcccac acctggctat gaggtgggcc agcggaagcg cctcatctcc     3900

tcggtggagg acttcaccga gtttgtg                                         3927


<210>  24
<211>  3801
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  24
atggccaaac caacaagcaa agattcaggc ttgaaggaga agtttaagat tctgttggga       60

ctgggaacac cgaggccaaa tcccaggtct gcagagggta aacagacgga gtttatcatc      120

accgcggaaa tactgagaga actgagcatg gaatgtggcc tcaacaatcg catccggatg      180

atagggcaga tttgtgaagt cgcaaaaacc aagaaatttg aagagcacgc agtggaagca      240

ctctggaagg cggtcgcgga tctgttgcag ccggagcggc cgctggaggc ccggcacgcg      300

gtgctggctc tgctgaaggc catcgtgcag gggcagggcg agcgtttggg ggtcctcaga      360

gccctcttct ttaaggtcat caaggattac ccttccaacg aagaccttca cgaaaggctg      420

gaggttttca aggccctcac agacaatggg agacacatca cctacttgga ggaagagctg      480

gctgactttg tcctgcagtg gatggatgtt ggcttgtcct cggaattcct tctggtgctg      540

gtgaacttgg tcaaattcaa tagctgttac ctcgacgagt acatcgcaag gatggttcag      600

atgatctgtc tgctgtgcgt ccggaccgcg tcctctgtgg acatagaggt ctccctgcag      660

gtgctggacg ccgtggtctg ctacaactgc ctgccggctg agagcctccc gctgttcatc      720

gttaccctct gtcgcaccat caacgtcaag gagctctgcg agccttgctg gaagctgatg      780

cggaacctcc ttggcaccca cctgggccac agcgccatct acaacatgtg ccacctcatg      840

gaggacagag cctacatgga ggacgcgccc ctgctgagag gagccgtgtt ttttgtgggc      900

atggctctct ggggagccca ccggctctat tctctcagga actcgccgac atctgtgttg      960

ccatcatttt accaggccat ggcatgtccg aacgaggtgg tgtcctatga gatcgtcctg     1020

tccatcacca ggctcatcaa gaagtatagg aaggagctcc aggtggtggc gtgggacatt     1080

ctgctgaaca tcatcgaacg gctccttcag cagctccaga ccttggacag cccggagctc     1140

aggaccatcg tccatgacct gttgaccacg gtggaggagc tgtgtgacca gaacgagttc     1200

cacgggtctc aggagagata ctttgaactg gtggagagat gtgcggacca gaggagcgga     1260

ggaggctccg gaggaggctc tggaggcggc agcggcggcg gcttcagggc ccggagtact     1320

agtctcaacg agagacccaa gagtagcagg atacagacgt ccctcaccag tgccagcttg     1380

gggtctgcag atgagaactc cgtggcccag gctgacgata gcctgaaaaa cctccacctg     1440

gagctcacgg aaacctgtct ggacatgatg gctcgatacg tcttctccaa cttcacggct     1500

gtcccgaaga ggtctcctgt gggcgagttc ctcctagcgg gtggcaggac caaaacctgg     1560

ctggttggga acaagcttgt cactgtgacg acaagcgtgg gaaccgggac ccggtcgtta     1620

ctaggcctgg actcggggga gctgcagtcc ggcccggagt cgagctccag ccccggggtg     1680

catgtgagac agaccaagga ggcgccggcc aagctggagt cccaggctgg gcagcaggtg     1740

tcccgtgggg cccgggatcg ggtccgttcc atgtcggggg gccatggtct tcgagttggc     1800

gccctggacg tgccggcctc ccagttcctg ggcagtgcca cttctccagg accacggact     1860

gcaccagccg cgaaacctga gaaggcctca gctggcaccc gggttcctgt gcaggagaag     1920

acgaacctgg cggcctatgt gcccctgctg acccagggct gggcggagat cctggtccgg     1980

aggcccacag ggaacaccag ctggctgatg agcctggaga acccgctcag ccctttctcc     2040

tcggacatca acaacatgcc cctgcaggag ctgtctaacg ccctcatggc ggctgagcgc     2100

ttcaaggagc accgggacac agccctgtac aagtcactgt cggtgccggc agccagcacg     2160

gccaaacccc ctcctctgcc tcgctccaac acagtggcct ctttctcctc cctgtaccag     2220

tccagctgcc aaggacagct gcacaggagc gtttcctggg cagactccgc cgtggtcatg     2280

gaggagggaa gtccgggcga ggttcctgtg ctggtggagc ccccagggtt ggaggacgtt     2340

gaggcagcgc taggcatgga caggcgcacg gatgcctaca gcaggtcgtc ctcagtctcc     2400

agccaggagg agaagtcgct ccacgcggag gagctggttg gcaggggcat ccccatcgag     2460

cgagtcgtct cctcggaggg tggccggccc tctgtggacc tctccttcca gccctcgcag     2520

cccctgagca agtccagctc ctctcccgag ctgcagactc tgcaggacat cctcggggac     2580

cctggggaca aggccgacgt gggccggctg agccctgagg ttaaggcccg gtcacagtca     2640

gggaccctgg acggggaaag tgctgcctgg tcggcctcgg gcgaagacag tcggggccag     2700

cccgagggtc ccttgccttc cagctccccc cgctcgccca gtggcctccg gccccgaggt     2760

tacaccatct ccgactcggc cccatcacgc aggggcaaga gagtagagag ggacgcctta     2820

aagagcagag ccacagcctc caatgcagag aaagtgccag gcatcaaccc cagtttcgtg     2880

ttcctgcagc tctaccattc ccccttcttt ggcgacgagt caaacaagcc aatcctgctg     2940

cccaatgagt cacagtcctt tgagcggtcg gtgcagctcc tcgaccagat cccatcatac     3000

gacacccaca agatcgccgt cctgtatgtt ggagaaggcc agagcaacag cgagctcgcc     3060

atcctgtcca atgagcatgg ctcctacagg tacacggagt tcctgacggg cctgggccgg     3120

ctcatcgagc tgaaggactg ccagccggac aaggtgtacc tgggaggcct ggacgtgtgt     3180

ggtgaggacg gccagttcac ctactgctgg cacgatgaca tcatgcaagc cgtcttccac     3240

atcgccaccc tgatgcccac caaggacgtg gacaagcacc gctgcgacaa gaagcgccac     3300

ctgggcaacg actttgtgtc cattgtctac aatgactccg gtgaggactt caagcttggc     3360

accatcaagg gccagttcaa ctttgtccac gtgatcgtca ccccgctgga ctacgagtgc     3420

aacctggtgt ccctgcagtg caggaaagac atggagggcc ttgtggacac cagcgtggcc     3480

aagatcgtgt ctgaccgcaa cctgcccttc gtggcccgcc agatggccct gcacgcaaat     3540

atggcctcac aggtgcatca tagccgctcc aaccccaccg atatctaccc ctccaagtgg     3600

attgcccggc tccgccacat caagcggctc cgccagcgga tctgcgagga agccgcctac     3660

tccaacccca gcctacctct ggtgcaccct ccgtcccata gcaaagcccc tgcacagact     3720

ccagccgagc ccacacctgg ctatgaggtg ggccagcgga agcgcctcat ctcctcggtg     3780

gaggacttca ccgagtttgt g                                               3801


<210>  25
<211>  3600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  25
atggccaaac caacaagcaa agattcaggc ttgaaggaga agtttaagat tctgttggga       60

ctgggaacac cgaggccaaa tcccaggtct gcagagggta aacagacgga gtttatcatc      120

accgcggaaa tactgagaga actgagcatg gaatgtggcc tcaacaatcg catccggatg      180

atagggcaga tttgtgaagt cgcaaaaacc aagaaatttg aagagcacgc agtggaagca      240

ctctggaagg cggtcgcgga tctgttgcag ccggagcggc cgctggaggc ccggcacgcg      300

gtgctggctc tgctgaaggc catcgtgcag gggcagggcg agcgtttggg ggtcctcaga      360

gccctcttct ttaaggtcat caaggattac ccttccaacg aagaccttca cgaaaggctg      420

gaggttttca aggccctcac agacaatggg agacacatca cctacttgga ggaagagctg      480

gctgactttg tcctgcagtg gatggatgtt ggcttgtcct cggaattcct tctggtgctg      540

gtgaacttgg tcaaattcaa tagctgttac ctcgacgagt acatcgcaag gatggttcag      600

atgatctgtc tgctgtgcgt ccggaccgcg tcctctgtgg acatagaggt ctccctgcag      660

gtgctggacg ccgtggtctg ctacaactgc ctgccggctg agagcctccc gctgttcatc      720

gttaccctct gtcgcaccat caacgtcaag gagctctgcg agccttgctg gaagctgatg      780

cggaacctcc ttggcaccca cctgggccac agcgccatct acaacatgtg ccacctcatg      840

gaggacagag cctacatgga ggacgcgccc ctgctgagag gagccgtgtt ttttgtgggc      900

atggctctct ggggagccca ccggctctat tctctcagga actcgccgac atctgtgttg      960

ccatcatttt accaggccat ggcatgtccg aacgaggtgg tgtcctatga gatcgtcctg     1020

tccatcacca ggctcatcaa gaagtatagg aaggagctcc aggtggtggc gtgggacatt     1080

ctgctgaaca tcatcgaacg gctccttcag cagctccaga ccttggacag cccggagctc     1140

aggaccatcg tccatgacct gttgaccacg gtggaggagc tgtgtgacca gaacgagttc     1200

cacgggtctc aggagagata ctttgaactg gtggagagat gtgcggacca gaggagcgga     1260

ggaggctccg gaggaggctc tggaggcggc agcggcggcg gcttcagggc ccggagtact     1320

agtctcaacg agagacccaa gagtagcagg atacagacgt ccctcaccag tgccagcttg     1380

gggtctgcag atgagaactc cgtggcccag gctgacgata gcctgaaaaa cctccacctg     1440

gagctcacgg aaacctgtct ggacatgatg gctcgatacg tcttctccaa cttcacggct     1500

gtcccgaaga ggtctcctgt gggcgagttc ctcctagcgg gtggcaggac caaaacctgg     1560

ctggttggga acaagcttgt cactgtgacg acaagcgtgg gaaccgggac ccggtcgtta     1620

ctaggcctgg actcggggga gctgcagtcc ggcccggagt cgagctccag ccccggggtg     1680

catgtgagac agaccaagga ggcgccggcc aagctggagt cccaggctgg gcagcaggtg     1740

tcccgtgggg cccgggatcg ggtccgttcc atgtcggggg gccatggtct tcgagttggc     1800

gccctggacg tgccggcctc ccagttcctg ggcagtgcca cttctccagg accacggact     1860

gcaccagccg cgaaacctga gaaggcctca gctggcaccc gggttcctgt gcaggagaag     1920

acgaacctgg cggcctatgt gcccctgctg acccagggct gggcggagat cctggtccgg     1980

aggcccacag gggtggcctc tttctcctcc ctgtaccagt ccagctgcca aggacagctg     2040

cacaggagcg tttcctgggc agactccgcc gtggtcatgg aggagggaag tccgggcgag     2100

gttcctgtgc tggtggagcc cccagggttg gaggacgttg aggcagcgct aggcatggac     2160

aggcgcacgg atgcctacag caggtcgtcc tcagtctcca gccaggagga gaagtcgctc     2220

cacgcggagg agctggttgg caggggcatc cccatcgagc gagtcgtctc ctcggagggt     2280

ggccggccct ctgtggacct ctccttccag ccctcgcagc ccctgagcaa gtccagctcc     2340

tctcccgagc tgcagactct gcaggacatc ctcggggacc ctggggacaa ggccgacgtg     2400

ggccggctga gccctgaggt taaggcccgg tcacagtcag ggaccctgga cggggaaagt     2460

gctgcctggt cggcctcggg cgaagacagt cggggccagc ccgagggtcc cttgccttcc     2520

agctcccccc gctcgcccag tggcctccgg ccccgaggtt acaccatctc cgactcggcc     2580

ccatcacgca ggggcaagag agtagagagg gacgccttaa agagcagagc cacagcctcc     2640

aatgcagaga aagtgccagg catcaacccc agtttcgtgt tcctgcagct ctaccattcc     2700

cccttctttg gcgacgagtc aaacaagcca atcctgctgc ccaatgagtc acagtccttt     2760

gagcggtcgg tgcagctcct cgaccagatc ccatcatacg acacccacaa gatcgccgtc     2820

ctgtatgttg gagaaggcca gagcaacagc gagctcgcca tcctgtccaa tgagcatggc     2880

tcctacaggt acacggagtt cctgacgggc ctgggccggc tcatcgagct gaaggactgc     2940

cagccggaca aggtgtacct gggaggcctg gacgtgtgtg gtgaggacgg ccagttcacc     3000

tactgctggc acgatgacat catgcaagcc gtcttccaca tcgccaccct gatgcccacc     3060

aaggacgtgg acaagcaccg ctgcgacaag aagcgccacc tgggcaacga ctttgtgtcc     3120

attgtctaca atgactccgg tgaggacttc aagcttggca ccatcaaggg ccagttcaac     3180

tttgtccacg tgatcgtcac cccgctggac tacgagtgca acctggtgtc cctgcagtgc     3240

aggaaagaca tggagggcct tgtggacacc agcgtggcca agatcgtgtc tgaccgcaac     3300

ctgcccttcg tggcccgcca gatggccctg cacgcaaata tggcctcaca ggtgcatcat     3360

agccgctcca accccaccga tatctacccc tccaagtgga ttgcccggct ccgccacatc     3420

aagcggctcc gccagcggat ctgcgaggaa gccgcctact ccaaccccag cctacctctg     3480

gtgcaccctc cgtcccatag caaagcccct gcacagactc cagccgagcc cacacctggc     3540

tatgaggtgg gccagcggaa gcgcctcatc tcctcggtgg aggacttcac cgagtttgtg     3600


<210>  26
<211>  3114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  26
atggccaaac caacaagcaa agattcaggc ttgaaggaga agtttaagat tctgttggga       60

ctgggaacac cgaggccaaa tcccaggtct gcagagggta aacagacgga gtttatcatc      120

accgcggaaa tactgagaga actgagcatg gaatgtggcc tcaacaatcg catccggatg      180

atagggcaga tttgtgaagt cgcaaaaacc aagaaatttg aagagcacgc agtggaagca      240

ctctggaagg cggtcgcgga tctgttgcag ccggagcggc cgctggaggc ccggcacgcg      300

gtgctggctc tgctgaaggc catcgtgcag gggcagggcg agcgtttggg ggtcctcaga      360

gccctcttct ttaaggtcat caaggattac ccttccaacg aagaccttca cgaaaggctg      420

gaggttttca aggccctcac agacaatggg agacacatca cctacttgga ggaagagctg      480

gctgactttg tcctgcagtg gatggatgtt ggcttgtcct cggaattcct tctggtgctg      540

gtgaacttgg tcaaattcaa tagctgttac ctcgacgagt acatcgcaag gatggttcag      600

atgatctgtc tgctgtgcgt ccggaccgcg tcctctgtgg acatagaggt ctccctgcag      660

gtgctggacg ccgtggtctg ctacaactgc ctgccggctg agagcctccc gctgttcatc      720

gttaccctct gtcgcaccat caacgtcaag gagctctgcg agccttgctg gaagctgatg      780

cggaacctcc ttggcaccca cctgggccac agcgccatct acaacatgtg ccacctcatg      840

gaggacagag cctacatgga ggacgcgccc ctgctgagag gagccgtgtt ttttgtgggc      900

atggctctct ggggagccca ccggctctat tctctcagga actcgccgac atctgtgttg      960

ccatcatttt accaggccat ggcatgtccg aacgaggtgg tgtcctatga gatcgtcctg     1020

tccatcacca ggctcatcaa gaagtatagg aaggagctcc aggtggtggc gtgggacatt     1080

ctgctgaaca tcatcgaacg gctccttcag cagctccaga ccttggacag cccggagctc     1140

aggaccatcg tccatgacct gttgaccacg gtggaggagc tgtgtgacca gaacgagttc     1200

cacgggtctc aggagagata ctttgaactg gtggagagat gtgcggacca gaggagcgga     1260

ggaggctccg gaggaggctc tggaggcggc agcggcggcg gcttcagggc ccggagtact     1320

agtctcaacg agagacccaa gagtagcagg atacagacgt ccctcaccag tgccagcttg     1380

gggtctgcag atgagaactc cgtggcccag gctgacgata gcctgaaaaa cctccacctg     1440

gagctcacgg aaacctgtct ggacatgatg gctcgatacg tcttctccaa cttcacggct     1500

gtcccgaaga ggtctcctgt gggcgagttc ctcctagcgg gtggcaggac caaaacctgg     1560

ctggttggga acaagcttgt cactgtgacg acaagcgtgg gaaccgggac ccggtcgtta     1620

ctaggcctgg actcggggga gctgcagtcc ggcccggagt cgagctccag ccccggggtg     1680

catgtgagac agaccaagga ggcgccggcc aagctggagt cccaggctgg gcagcaggtg     1740

tcccgtgggg cccgggatcg ggtccgttcc atgtcggggg gccatggtct tcgagttggc     1800

gccctggacg tgccggcctc ccagttcctg ggcagtgcca cttctccagg accacggact     1860

gcaccagccg cgaaacctga gaaggcctca gctggcaccc gggttcctgt gcaggagaag     1920

acgaacctgg cggcctatgt gcccctgctg acccagggct gggcggagat cctggtccgg     1980

aggcccacag gggtggcctc tttctcctcc ctgtaccagt ccagctgcca aggacagctg     2040

cacaggagcg tttcctgggc agactccgcc gtggtcatgg aggagggaag tccgggcgag     2100

gttcctgtgc tggtggagcc cccagggttg gaggacgttg aggcagcgct aggcatggac     2160

aggcgcacgg atgcctacag caggagtttc gtgttcctgc agctctacca ttcccccttc     2220

tttggcgacg agtcaaacaa gccaatcctg ctgcccaatg agtcacagtc ctttgagcgg     2280

tcggtgcagc tcctcgacca gatcccatca tacgacaccc acaagatcgc cgtcctgtat     2340

gttggagaag gccagagcaa cagcgagctc gccatcctgt ccaatgagca tggctcctac     2400

aggtacacgg agttcctgac gggcctgggc cggctcatcg agctgaagga ctgccagccg     2460

gacaaggtgt acctgggagg cctggacgtg tgtggtgagg acggccagtt cacctactgc     2520

tggcacgatg acatcatgca agccgtcttc cacatcgcca ccctgatgcc caccaaggac     2580

gtggacaagc accgctgcga caagaagcgc cacctgggca acgactttgt gtccattgtc     2640

tacaatgact ccggtgagga cttcaagctt ggcaccatca agggccagtt caactttgtc     2700

cacgtgatcg tcaccccgct ggactacgag tgcaacctgg tgtccctgca gtgcaggaaa     2760

gacatggagg gccttgtgga caccagcgtg gccaagatcg tgtctgaccg caacctgccc     2820

ttcgtggccc gccagatggc cctgcacgca aatatggcct cacaggtgca tcatagccgc     2880

tccaacccca ccgatatcta cccctccaag tggattgccc ggctccgcca catcaagcgg     2940

ctccgccagc ggatctgcga ggaagccgcc tactccaacc ccagcctacc tctggtgcac     3000

cctccgtccc atagcaaagc ccctgcacag actccagccg agcccacacc tggctatgag     3060

gtgggccagc ggaagcgcct catctcctcg gtggaggact tcaccgagtt tgtg           3114


<210>  27
<211>  130
<212>  DNA
<213>  Unknown

<220>
<223>  5' ITR

<400>  27
ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt       60

gcccgggcgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  28
<211>  130
<212>  DNA
<213>  Unknown

<220>
<223>  3' ITR

<400>  28
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag                                                             130


<210>  29
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  29

Leu Arg Ile Ala Arg Pro Pro Lys Gln Gly Leu Asn Asn Ser Pro Pro 
1               5                   10                  15      


Val Lys Glu Phe Lys Glu Ser Ser Ala Ala Glu Ala Phe Arg Cys Arg 
            20                  25                  30          


Ser Ile Ser Val Ser Glu His Val Val Arg 
        35                  40          


<210>  30
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  30

Asn Thr Ser Trp Leu Met Ser Leu Glu Asn Pro Leu Ser Pro Phe Ser 
1               5                   10                  15      


Ser Asp Ile Asn Asn Met Pro Leu Gln Glu Leu Ser Asn Ala Leu Met 
            20                  25                  30          


Ala Ala Glu Arg Phe Lys Glu His Arg Asp Thr Ala Leu Tyr Lys Ser 
        35                  40                  45              


Leu Ser Val Pro Ala Ala Ser Thr Ala Lys Pro Pro Pro Leu Pro Arg 
    50                  55                  60                  


Ser Asn Thr 
65          


<210>  31
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  31

Ser Ser Ser Val Ser Ser Gln Glu Glu Lys Ser Leu His Ala Glu Glu 
1               5                   10                  15      


Leu Val Gly Arg Gly Ile Pro Ile Glu Arg Val Val Ser Ser Glu Gly 
            20                  25                  30          


Gly Arg Pro Ser Val Asp Leu Ser Phe Gln Pro Ser Gln Pro Leu Ser 
        35                  40                  45              


Lys Ser Ser Ser Ser Pro Glu Leu Gln Thr Leu Gln Asp Ile Leu Gly 
    50                  55                  60                  


Asp Pro Gly Asp Lys Ala Asp Val Gly Arg Leu Ser Pro Glu Val Lys 
65                  70                  75                  80  


Ala Arg Ser Gln Ser Gly Thr Leu Asp Gly Glu Ser Ala Ala Trp Ser 
                85                  90                  95      


Ala Ser Gly Glu Asp Ser Arg Gly Gln Pro Glu Gly Pro Leu Pro Ser 
            100                 105                 110         


Ser Ser Pro Arg Ser Pro Ser Gly Leu Arg Pro Arg Gly Tyr Thr Ile 
        115                 120                 125             


Ser Asp Ser Ala Pro Ser Arg Arg Gly Lys Arg Val Glu Arg Asp Ala 
    130                 135                 140                 


Leu Lys Ser Arg Ala Thr Ala Ser Asn Ala Glu Lys Val Pro Gly Ile 
145                 150                 155                 160 


Asn Pro 
        


<210>  32
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  32

Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro Lys Ser Leu Arg 
1               5                   10                  15      


Ile Ala Arg Pro Pro Lys Gln Gly Leu Asn Asn Ser Pro Pro Val Lys 
            20                  25                  30          


Glu Phe Lys Glu Ser Ser Ala Ala Glu Ala Phe Arg Cys Arg Ser Ile 
        35                  40                  45              


Ser Val Ser Glu His Val Val Arg Ser Arg Ile Gln Thr Ser Leu Thr 
    50                  55                  60                  


Ser Ala Ser Leu Gly Ser Ala Asp Glu Asn Ser Val Ala Gln Ala Asp 
65                  70                  75                  80  


Asp Ser Leu Lys Asn Leu His Leu Glu Leu Thr Glu Thr Cys Leu Asp 
                85                  90                  95      


Met Met Ala Arg Tyr Val Phe Ser Asn Phe Thr Ala Val Pro Lys Arg 
            100                 105                 110         


Ser Pro Val Gly Glu Phe Leu Leu Ala Gly Gly Arg Thr Lys Thr Trp 
        115                 120                 125             


Leu Val Gly Asn Lys Leu Val Thr Val Thr Thr Ser Val Gly Thr Gly 
    130                 135                 140                 


Thr Arg Ser Leu Leu Gly Leu Asp Ser Gly Glu Leu Gln Ser Gly Pro 
145                 150                 155                 160 


Glu Ser Ser Ser Ser Pro Gly Val His Val Arg Gln Thr Lys Glu Ala 
                165                 170                 175     


Pro 
    


<210>  33
<211>  382
<212>  DNA
<213>  Unknown

<220>
<223>  CMV-IE URE

<400>  33
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt ac                                               382


<210>  34
<211>  260
<212>  DNA
<213>  Unknown

<220>
<223>  CB6 promoter

<400>  34
ccacgttctg cttcactctc cccatctccc ccccctcccc acccccaatt ttgtatttat       60

ttatttttta attattttgt gcagcgatgg gggcgggggg ggggggcgcg cgccaggcgg      120

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      180

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      240

aaagcgaagc gcgcggcggg                                                  260


<210>  35
<211>  6
<212>  DNA
<213>  Unknown

<220>
<223>  Kozak sequence

<400>  35
gccacc                                                                   6


<210>  36
<211>  56
<212>  DNA
<213>  Unknown

<220>
<223>  Rabbit polyA sequence

<400>  36
aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt ctctca           56


