                         SEQUENCE LISTING

<110>  Chan Zuckerburg Biohub, Inc.
       The Regents of the University of California
       Mostajo Radji, Mohammed Andres
       Pollen, Alexander A.
 
<120>  METHODS FOR GENERATING PARVALBUMIN-POSITIVE INTERNEURONS

<130>  CZBH-002WO

<150>  US 63/210,742
<151>  2021-06-15

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  110
<212>  PRT
<213>  Mus musculus

<400>  1

Met Ser Met Thr Asp Val Leu Ser Ala Glu Asp Ile Lys Lys Ala Ile 
1               5                   10                  15      


Gly Ala Phe Ala Ala Ala Asp Ser Phe Asp His Lys Lys Phe Phe Gln 
            20                  25                  30          


Met Val Gly Leu Lys Lys Lys Asn Pro Asp Glu Val Lys Lys Val Phe 
        35                  40                  45              


His Ile Leu Asp Lys Asp Lys Ser Gly Phe Ile Glu Glu Asp Glu Leu 
    50                  55                  60                  


Gly Ser Ile Leu Lys Gly Phe Ser Ser Asp Ala Arg Asp Leu Ser Ala 
65                  70                  75                  80  


Lys Glu Thr Lys Thr Leu Leu Ala Ala Gly Asp Lys Asp Gly Asp Gly 
                85                  90                  95      


Lys Ile Gly Val Glu Glu Phe Ser Thr Leu Val Ala Glu Ser 
            100                 105                 110 


<210>  2
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  2

Met Leu Ser Cys Arg Leu Gln Cys Ala Leu Ala Ala Leu Cys Ile Val 
1               5                   10                  15      


Leu Ala Leu Gly Gly Val Thr Gly Ala Pro Ser Asp Pro Arg Leu Arg 
            20                  25                  30          


Gln Phe Leu Gln Lys Ser Leu Ala Ala Ala Thr Gly Lys Gln Glu Leu 
        35                  40                  45              


Ala Lys Tyr Phe Leu Ala Glu Leu Leu Ser Glu Pro Asn Gln Thr Glu 
    50                  55                  60                  


Asn Asp Ala Leu Glu Pro Glu Asp Leu Pro Gln Ala Ala Glu Gln Asp 
65                  70                  75                  80  


Glu Met Arg Leu Glu Leu Gln Arg Ser Ala Asn Ser Asn Pro Ala Met 
                85                  90                  95      


Ala Pro Arg Glu Arg Lys Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr 
            100                 105                 110         


Phe Thr Ser Cys 
        115     


<210>  3
<211>  466
<212>  PRT
<213>  Mus musculus

<400>  3

Met Gly Arg Lys Lys Ile Gln Ile Thr Arg Ile Met Asp Glu Arg Asn 
1               5                   10                  15      


Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala 
            20                  25                  30          


Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe 
        35                  40                  45              


Asn Ser Thr Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys 
    50                  55                  60                  


Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr 
65                  70                  75                  80  


Asn Ser Asp Ile Val Glu Thr Leu Arg Lys Lys Gly Leu Asn Gly Cys 
                85                  90                  95      


Asp Ser Pro Asp Pro Asp Ala Asp Asp Ser Val Gly His Ser Pro Glu 
            100                 105                 110         


Ser Glu Asp Lys Tyr Arg Lys Ile Asn Glu Asp Ile Asp Leu Met Ile 
        115                 120                 125             


Ser Arg Gln Arg Leu Cys Ala Val Pro Pro Pro Ser Phe Glu Met Pro 
    130                 135                 140                 


Val Thr Ile Pro Val Ser Ser His Asn Ser Leu Val Tyr Ser Asn Pro 
145                 150                 155                 160 


Val Ser Thr Leu Gly Asn Pro Asn Leu Leu Pro Leu Ala His Pro Ser 
                165                 170                 175     


Leu Gln Arg Asn Ser Met Ser Pro Gly Val Thr His Arg Pro Pro Ser 
            180                 185                 190         


Ala Gly Asn Thr Gly Gly Leu Met Gly Gly Asp Leu Thr Ser Gly Ala 
        195                 200                 205             


Gly Thr Ser Ala Gly Asn Gly Tyr Gly Asn Pro Arg Asn Ser Pro Gly 
    210                 215                 220                 


Leu Leu Val Ser Pro Gly Asn Leu Asn Lys Asn Ile Gln Ala Lys Ser 
225                 230                 235                 240 


Pro Pro Pro Met Asn Leu Gly Met Asn Asn Arg Lys Pro Asp Leu Arg 
                245                 250                 255     


Val Leu Ile Pro Pro Gly Ser Lys Asn Thr Met Pro Ser Val Asn Gln 
            260                 265                 270         


Arg Ile Asn Asn Ser Gln Ser Ala Gln Ser Leu Ala Thr Pro Val Val 
        275                 280                 285             


Ser Val Ala Thr Pro Thr Leu Pro Gly Gln Gly Met Gly Gly Tyr Pro 
    290                 295                 300                 


Ser Ala Ile Ser Thr Thr Tyr Gly Thr Glu Tyr Ser Leu Ser Ser Ala 
305                 310                 315                 320 


Asp Leu Ser Ser Leu Ser Gly Phe Asn Thr Ala Ser Ala Leu His Leu 
                325                 330                 335     


Gly Ser Val Thr Gly Trp Gln Gln Gln His Leu His Asn Met Pro Pro 
            340                 345                 350         


Ser Ala Leu Ser Gln Leu Gly Ala Cys Thr Ser Thr His Leu Ser Gln 
        355                 360                 365             


Ser Ser Asn Leu Ser Leu Pro Ser Thr Gln Ser Leu Ser Ile Lys Ser 
    370                 375                 380                 


Glu Pro Val Ser Pro Pro Arg Asp Arg Thr Thr Thr Pro Ser Arg Tyr 
385                 390                 395                 400 


Pro Gln His Thr Thr Arg His Glu Ala Gly Arg Ser Pro Val Asp Ser 
                405                 410                 415     


Leu Ser Ser Cys Ser Ser Ser Tyr Asp Gly Ser Asp Arg Glu Asp His 
            420                 425                 430         


Arg Asn Glu Phe His Ser Pro Ile Gly Leu Thr Arg Pro Ser Pro Asp 
        435                 440                 445             


Glu Arg Glu Ser Pro Ser Val Lys Arg Met Arg Leu Ser Glu Gly Trp 
    450                 455                 460                 


Ala Thr 
465     


<210>  4
<211>  585
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Ser Pro Gly Ser Gly Phe Trp Ser Phe Gly Ser Glu Asp Gly 
1               5                   10                  15      


Ser Ala Asp Pro Glu Asn Pro Gly Thr Ala Arg Ala Trp Cys Gln Val 
            20                  25                  30          


Ala Gln Lys Phe Thr Gly Gly Ile Gly Asn Lys Leu Cys Ala Leu Leu 
        35                  40                  45              


Tyr Gly Asp Ser Gly Lys Pro Ala Glu Gly Gly Gly Ser Val Thr Ser 
    50                  55                  60                  


Arg Ala Ala Thr Gly Lys Val Ala Cys Thr Cys Asp Gln Lys Pro Cys 
65                  70                  75                  80  


Asn Cys Pro Lys Gly Asp Val Asn Tyr Ala Phe Leu His Ala Thr Asp 
                85                  90                  95      


Leu Leu Pro Ala Cys Asp Gly Glu Arg Pro Thr Leu Ala Phe Leu Gln 
            100                 105                 110         


Asp Val Met Asn Ile Leu Leu Gln Tyr Val Val Lys Ser Phe Asp Arg 
        115                 120                 125             


Ser Thr Lys Val Ile Asp Phe His Tyr Pro Asn Glu Leu Leu Gln Glu 
    130                 135                 140                 


Tyr Asn Trp Glu Leu Ala Asp Gln Pro Gln Asn Leu Glu Glu Ile Leu 
145                 150                 155                 160 


Thr His Cys Gln Thr Thr Leu Lys Tyr Ala Ile Lys Thr Gly His Pro 
                165                 170                 175     


Arg Tyr Phe Asn Gln Leu Ser Thr Gly Leu Asp Met Val Gly Leu Ala 
            180                 185                 190         


Ala Asp Trp Leu Thr Ser Thr Ala Asn Thr Asn Met Phe Thr Tyr Glu 
        195                 200                 205             


Ile Ala Pro Val Phe Val Leu Leu Glu Tyr Val Thr Leu Lys Lys Met 
    210                 215                 220                 


Arg Glu Ile Ile Gly Trp Pro Gly Gly Ser Gly Asp Gly Ile Phe Ser 
225                 230                 235                 240 


Pro Gly Gly Ala Ile Ser Asn Met Tyr Ala Met Leu Ile Ala Arg Tyr 
                245                 250                 255     


Lys Met Phe Pro Glu Val Lys Glu Lys Gly Met Ala Ala Val Pro Arg 
            260                 265                 270         


Leu Ile Ala Phe Thr Ser Glu His Ser His Phe Ser Leu Lys Lys Gly 
        275                 280                 285             


Ala Ala Ala Leu Gly Ile Gly Thr Asp Ser Val Ile Leu Ile Lys Cys 
    290                 295                 300                 


Asp Glu Arg Gly Lys Met Ile Pro Ser Asp Leu Glu Arg Arg Ile Leu 
305                 310                 315                 320 


Glu Val Lys Gln Lys Gly Phe Val Pro Phe Leu Val Ser Ala Thr Ala 
                325                 330                 335     


Gly Thr Thr Val Tyr Gly Ala Phe Asp Pro Leu Leu Ala Val Ala Asp 
            340                 345                 350         


Ile Cys Lys Lys Tyr Lys Ile Trp Met His Val Asp Ala Ala Trp Gly 
        355                 360                 365             


Gly Gly Leu Leu Met Ser Arg Lys His Lys Trp Lys Leu Ser Gly Val 
    370                 375                 380                 


Glu Arg Ala Asn Ser Val Thr Trp Asn Pro His Lys Met Met Gly Val 
385                 390                 395                 400 


Pro Leu Gln Cys Ser Ala Leu Leu Val Arg Glu Glu Gly Leu Met Gln 
                405                 410                 415     


Ser Cys Asn Gln Met His Ala Ser Tyr Leu Phe Gln Gln Asp Lys His 
            420                 425                 430         


Tyr Asp Leu Ser Tyr Asp Thr Gly Asp Lys Ala Leu Gln Cys Gly Arg 
        435                 440                 445             


His Val Asp Val Phe Lys Leu Trp Leu Met Trp Arg Ala Lys Gly Thr 
    450                 455                 460                 


Thr Gly Phe Glu Ala His Ile Asp Lys Cys Leu Glu Leu Ala Glu Tyr 
465                 470                 475                 480 


Leu Tyr Thr Ile Ile Lys Asn Arg Glu Gly Tyr Glu Met Val Phe Asp 
                485                 490                 495     


Gly Lys Pro Gln His Thr Asn Val Cys Phe Trp Phe Val Pro Pro Ser 
            500                 505                 510         


Leu Arg Thr Leu Glu Asp Asn Glu Glu Arg Met Ser Arg Leu Ser Lys 
        515                 520                 525             


Val Ala Pro Val Ile Lys Ala Arg Met Met Glu Tyr Gly Thr Thr Met 
    530                 535                 540                 


Val Ser Tyr Gln Pro Leu Gly Asp Lys Val Asn Phe Phe Arg Met Val 
545                 550                 555                 560 


Ile Ser Asn Pro Ala Ala Thr His Gln Asp Ile Asp Phe Leu Ile Glu 
                565                 570                 575     


Glu Ile Glu Arg Leu Gly Gln Asp Leu 
            580                 585 


<210>  5
<211>  146
<212>  PRT
<213>  Mus musculus

<400>  5

Met Thr Gly Val Phe Asp Arg Arg Val Pro Ser Ile Arg Ser Gly Asp 
1               5                   10                  15      


Phe Gln Ala Pro Phe Pro Thr Ser Ala Ala Met His His Pro Ser Gln 
            20                  25                  30          


Glu Ser Pro Thr Leu Pro Glu Ser Ser Ala Thr Asp Ser Asp Tyr Tyr 
        35                  40                  45              


Ser Pro Ala Gly Ala Ala Pro His Gly Tyr Cys Ser Pro Thr Ser Ala 
    50                  55                  60                  


Ser Tyr Gly Lys Ala Leu Asn Pro Tyr Gln Tyr Gln Tyr His Gly Val 
65                  70                  75                  80  


Asn Gly Ser Ala Ala Gly Tyr Pro Ala Lys Ala Tyr Ala Asp Tyr Gly 
                85                  90                  95      


Tyr Ala Ser Pro Tyr His Gln Tyr Gly Gly Ala Tyr Asn Arg Val Pro 
            100                 105                 110         


Ser Ala Thr Ser Gln Pro Ala Phe Ser Trp Pro Leu Tyr Arg Glu Gly 
        115                 120                 125             


Phe Arg Arg Leu Ser Thr Ser Pro Cys Gln Asn Ala Arg Ser Trp Pro 
    130                 135                 140                 


Pro Leu 
145     


<210>  6
<211>  297
<212>  PRT
<213>  Mus musculus

<400>  6

Met Met Thr Met Thr Thr Met Ala Asp Gly Leu Glu Gly Gln Asp Ser 
1               5                   10                  15      


Ser Lys Ser Ala Phe Met Glu Phe Gly Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Pro His Ser Gln Gln Thr 
    50                  55                  60                  


Ser Pro Ala Met Ala Gly Ala His Tyr Pro Leu His Cys Leu His Ser 
65                  70                  75                  80  


Ala Ala Ala Ala Ala Ala Ala Ala Gly Ser His His His His His Gln 
                85                  90                  95      


His His His His Gly Ser Pro Tyr Ala Ser Ser Gly Gly Asn Ser Tyr 
            100                 105                 110         


Asn His Arg Ser Leu Ala Ala Tyr Pro Tyr Met Ser His Ser Gln His 
        115                 120                 125             


Ser Pro Tyr Leu Gln Ser Tyr His Asn Ser Ser Ala Ala Ala Gln Thr 
    130                 135                 140                 


Arg Gly Asp Asp Thr Asp Gln Gln Lys Thr Thr Val Ile Glu Asn Gly 
145                 150                 155                 160 


Glu Ile Arg Phe Asn Gly Lys Gly Lys Lys Ile Arg Lys Pro Arg Thr 
                165                 170                 175     


Ile Tyr Ser Ser Leu Gln Leu Gln Ala Leu Asn His Arg Phe Gln Gln 
            180                 185                 190         


Thr Gln Tyr Leu Ala Leu Pro Glu Arg Ala Glu Leu Ala Ala Ser Leu 
        195                 200                 205             


Gly Leu Thr Gln Thr Gln Val Lys Ile Trp Phe Gln Asn Lys Arg Ser 
    210                 215                 220                 


Lys Phe Lys Lys Leu Leu Lys Gln Gly Ser Asn Pro His Glu Ser Asp 
225                 230                 235                 240 


Pro Leu Pro Gly Ser Ala Ala Leu Ser Pro Arg Ser Pro Ala Leu Pro 
                245                 250                 255     


Pro Val Trp Asp Val Ser Ala Ser Ala Lys Gly Val Ser Met Pro Pro 
            260                 265                 270         


Asn Ser Tyr Met Pro Gly Tyr Ser His Trp Tyr Ser Ser Pro His Gln 
        275                 280                 285             


Asp Thr Met Gln Arg Pro Gln Met Met 
    290                 295         


<210>  7
<211>  372
<212>  PRT
<213>  Mus musculus

<400>  7

Met Ser Met Ser Pro Lys His Thr Thr Pro Phe Ser Val Ser Asp Ile 
1               5                   10                  15      


Leu Ser Pro Leu Glu Glu Ser Tyr Lys Lys Val Gly Met Glu Gly Gly 
            20                  25                  30          


Gly Leu Gly Ala Pro Leu Ala Ala Tyr Arg Gln Gly Gln Ala Ala Pro 
        35                  40                  45              


Pro Ala Ala Ala Met Gln Gln His Ala Val Gly His His Gly Ala Val 
    50                  55                  60                  


Thr Ala Ala Tyr His Met Thr Ala Ala Gly Val Pro Gln Leu Ser His 
65                  70                  75                  80  


Ser Ala Val Gly Gly Tyr Cys Asn Gly Asn Leu Gly Asn Met Ser Glu 
                85                  90                  95      


Leu Pro Pro Tyr Gln Asp Thr Met Arg Asn Ser Ala Ser Gly Pro Gly 
            100                 105                 110         


Trp Tyr Gly Ala Asn Pro Asp Pro Arg Phe Pro Ala Ile Ser Arg Phe 
        115                 120                 125             


Met Gly Pro Ala Ser Gly Met Asn Met Ser Gly Met Gly Gly Leu Gly 
    130                 135                 140                 


Ser Leu Gly Asp Val Ser Lys Asn Met Ala Pro Leu Pro Ser Ala Pro 
145                 150                 155                 160 


Arg Arg Lys Arg Arg Val Leu Phe Ser Gln Ala Gln Val Tyr Glu Leu 
                165                 170                 175     


Glu Arg Arg Phe Lys Gln Gln Lys Tyr Leu Ser Ala Pro Glu Arg Glu 
            180                 185                 190         


His Leu Ala Ser Met Ile His Leu Thr Pro Thr Gln Val Lys Ile Trp 
        195                 200                 205             


Phe Gln Asn His Arg Tyr Lys Met Lys Arg Gln Ala Lys Asp Lys Ala 
    210                 215                 220                 


Ala Gln Gln Gln Leu Gln Gln Asp Ser Gly Gly Gly Gly Gly Gly Gly 
225                 230                 235                 240 


Gly Gly Ala Gly Cys Pro Gln Gln Gln Gln Ala Gln Gln Gln Ser Pro 
                245                 250                 255     


Arg Arg Val Ala Val Pro Val Leu Val Lys Asp Gly Lys Pro Cys Gln 
            260                 265                 270         


Ala Gly Ala Pro Ala Pro Gly Ala Ala Ser Leu Gln Ser His Ala Gln 
        275                 280                 285             


Gln Gln Ala Gln Gln Gln Ala Gln Ala Ala Gln Ala Ala Ala Ala Ala 
    290                 295                 300                 


Ile Ser Val Gly Ser Gly Gly Ala Gly Leu Gly Ala His Pro Gly His 
305                 310                 315                 320 


Gln Pro Gly Ser Ala Gly Gln Ser Pro Asp Leu Ala His His Ala Ala 
                325                 330                 335     


Ser Pro Ala Gly Leu Gln Gly Gln Val Ser Ser Leu Ser His Leu Asn 
            340                 345                 350         


Ser Ser Gly Ser Asp Tyr Gly Ala Met Ser Cys Ser Thr Leu Leu Tyr 
        355                 360                 365             


Gly Arg Thr Trp 
    370         


<210>  8
<211>  2549
<212>  PRT
<213>  Mus musculus

<400>  8

Met Leu Gly Thr Gly Pro Ala Val Ala Thr Ala Ser Ala Ala Thr Ser 
1               5                   10                  15      


Ser Asn Val Ser Val Leu Gln Gln Phe Ala Ser Gly Leu Lys Ser Arg 
            20                  25                  30          


Asn Glu Glu Thr Arg Ala Lys Ala Ala Lys Glu Leu Gln His Tyr Val 
        35                  40                  45              


Thr Met Glu Leu Arg Glu Met Ser Gln Glu Glu Ser Thr Arg Phe Tyr 
    50                  55                  60                  


Asp Gln Leu Asn His His Ile Phe Glu Leu Val Ser Ser Ser Asp Ala 
65                  70                  75                  80  


Asn Glu Arg Lys Gly Gly Ile Leu Ala Ile Ala Ser Leu Ile Gly Val 
                85                  90                  95      


Glu Gly Gly Asn Ser Thr Arg Ile Gly Arg Phe Ala Asn Tyr Leu Arg 
            100                 105                 110         


Asn Leu Leu Pro Ser Ser Asp Pro Val Val Met Glu Met Ala Ser Lys 
        115                 120                 125             


Ala Ile Gly Arg Leu Ala Met Ala Gly Asp Thr Phe Thr Ala Glu Tyr 
    130                 135                 140                 


Val Glu Phe Glu Val Lys Arg Ala Leu Glu Trp Leu Gly Ala Asp Arg 
145                 150                 155                 160 


Asn Glu Gly Arg Arg His Ala Ala Val Leu Val Leu Arg Glu Leu Ala 
                165                 170                 175     


Ile Ser Val Pro Thr Phe Phe Phe Gln Gln Val Gln Pro Phe Phe Asp 
            180                 185                 190         


Asn Ile Phe Val Ala Val Trp Asp Pro Lys Gln Ala Ile Arg Glu Gly 
        195                 200                 205             


Ala Val Ala Ala Leu Arg Ala Cys Leu Ile Leu Thr Thr Gln Arg Glu 
    210                 215                 220                 


Pro Lys Glu Met Gln Lys Pro Gln Trp Tyr Arg His Thr Phe Glu Glu 
225                 230                 235                 240 


Ala Glu Lys Gly Phe Asp Glu Thr Leu Ala Lys Glu Lys Gly Met Asn 
                245                 250                 255     


Arg Asp Asp Arg Ile His Gly Ala Leu Leu Ile Leu Asn Glu Leu Val 
            260                 265                 270         


Arg Ile Ser Ser Met Glu Gly Glu Arg Leu Arg Glu Glu Met Glu Glu 
        275                 280                 285             


Ile Thr Gln Gln Gln Leu Val His Asp Lys Tyr Cys Lys Asp Leu Met 
    290                 295                 300                 


Gly Phe Gly Thr Lys Pro Arg His Ile Thr Pro Phe Thr Ser Phe Gln 
305                 310                 315                 320 


Ala Val Gln Pro Gln Gln Pro Asn Ala Leu Val Gly Leu Leu Gly Tyr 
                325                 330                 335     


Ser Ser Pro Gln Gly Leu Met Gly Phe Gly Thr Ser Pro Ser Pro Ala 
            340                 345                 350         


Lys Ser Thr Leu Val Glu Ser Arg Cys Cys Arg Asp Leu Met Glu Glu 
        355                 360                 365             


Lys Phe Asp Gln Val Cys Gln Trp Val Leu Lys Cys Arg Ser Ser Lys 
    370                 375                 380                 


Asn Ser Leu Ile Gln Met Thr Ile Leu Asn Leu Leu Pro Arg Leu Ala 
385                 390                 395                 400 


Ala Phe Arg Pro Ser Ala Phe Thr Asp Thr Gln Tyr Leu Gln Asp Thr 
                405                 410                 415     


Met Asn His Val Leu Ser Cys Val Lys Lys Glu Lys Glu Arg Thr Ala 
            420                 425                 430         


Ala Phe Gln Ala Leu Gly Leu Leu Ser Val Ala Val Arg Ser Glu Phe 
        435                 440                 445             


Lys Val Tyr Leu Pro Arg Val Leu Asp Ile Ile Arg Ala Ala Leu Pro 
    450                 455                 460                 


Pro Lys Asp Phe Ala His Lys Arg Gln Lys Thr Val Gln Val Asp Ala 
465                 470                 475                 480 


Thr Val Phe Thr Cys Ile Ser Met Leu Ala Arg Ala Met Gly Pro Gly 
                485                 490                 495     


Ile Gln Gln Asp Ile Lys Glu Leu Leu Glu Pro Met Leu Ala Val Gly 
            500                 505                 510         


Leu Ser Pro Ala Leu Thr Ala Val Leu Tyr Asp Leu Ser Arg Gln Ile 
        515                 520                 525             


Pro Gln Leu Lys Lys Asp Ile Gln Asp Gly Leu Leu Lys Met Leu Ser 
    530                 535                 540                 


Leu Val Leu Met His Lys Pro Leu Arg His Pro Gly Met Pro Lys Gly 
545                 550                 555                 560 


Leu Ala His Gln Leu Ala Ser Pro Gly Leu Thr Thr Leu Pro Glu Ala 
                565                 570                 575     


Ser Asp Val Ala Ser Ile Thr Leu Ala Leu Arg Thr Leu Gly Ser Phe 
            580                 585                 590         


Glu Phe Glu Gly His Ser Leu Thr Gln Phe Val Arg His Cys Ala Asp 
        595                 600                 605             


His Phe Leu Asn Ser Glu His Lys Glu Ile Arg Met Glu Ala Ala Arg 
    610                 615                 620                 


Thr Cys Ser Arg Leu Leu Thr Pro Ser Ile His Leu Ile Ser Gly His 
625                 630                 635                 640 


Ala His Val Val Ser Gln Thr Ala Val Gln Val Val Ala Asp Val Leu 
                645                 650                 655     


Ser Lys Leu Leu Val Val Gly Ile Thr Asp Pro Asp Pro Asp Ile Arg 
            660                 665                 670         


Tyr Cys Val Leu Ala Ser Leu Asp Glu Arg Phe Asp Ala His Leu Ala 
        675                 680                 685             


Gln Ala Glu Asn Leu Gln Ala Leu Phe Val Ala Leu Asn Asp Gln Val 
    690                 695                 700                 


Phe Glu Ile Arg Glu Leu Ala Ile Cys Thr Val Gly Arg Leu Ser Ser 
705                 710                 715                 720 


Met Asn Pro Ala Phe Val Met Pro Phe Leu Arg Lys Met Leu Ile Gln 
                725                 730                 735     


Ile Leu Thr Glu Leu Glu His Ser Gly Ile Gly Arg Ile Lys Glu Gln 
            740                 745                 750         


Ser Ala Arg Met Leu Gly His Leu Val Ser Asn Ala Pro Arg Leu Ile 
        755                 760                 765             


Arg Pro Tyr Met Glu Pro Ile Leu Lys Ala Leu Ile Leu Lys Leu Lys 
    770                 775                 780                 


Asp Pro Asp Pro Asp Pro Asn Pro Gly Val Ile Asn Asn Val Leu Ala 
785                 790                 795                 800 


Thr Ile Gly Glu Leu Ala Gln Val Ser Gly Leu Glu Met Arg Lys Trp 
                805                 810                 815     


Val Asp Glu Leu Phe Ile Ile Ile Met Asp Met Leu Gln Asp Ser Ser 
            820                 825                 830         


Leu Leu Ala Lys Arg Gln Val Ala Leu Trp Thr Leu Gly Gln Leu Val 
        835                 840                 845             


Ala Ser Thr Gly Tyr Val Val Glu Pro Tyr Arg Lys Tyr Pro Thr Leu 
    850                 855                 860                 


Leu Glu Val Leu Leu Asn Phe Leu Lys Thr Glu Gln Asn Gln Gly Thr 
865                 870                 875                 880 


Arg Arg Glu Ala Ile Arg Val Leu Gly Leu Leu Gly Ala Leu Asp Pro 
                885                 890                 895     


Tyr Lys His Lys Val Asn Ile Gly Met Ile Asp Gln Ser Arg Asp Ala 
            900                 905                 910         


Ser Ala Val Ser Leu Ser Glu Ser Lys Ser Ser Gln Asp Ser Ser Asp 
        915                 920                 925             


Tyr Ser Thr Ser Glu Met Leu Val Asn Met Gly Asn Leu Pro Leu Asp 
    930                 935                 940                 


Glu Phe Tyr Pro Ala Val Ser Met Val Ala Leu Met Arg Ile Phe Arg 
945                 950                 955                 960 


Asp Gln Ser Leu Ser His His His Thr Met Val Val Gln Ala Ile Thr 
                965                 970                 975     


Phe Ile Phe Lys Ser Leu Gly Leu Lys Cys Val Gln Phe Leu Pro Gln 
            980                 985                 990         


Val Met Pro Thr Phe Leu Asn Val  Ile Arg Val Cys Asp  Gly Ala Ile 
        995                 1000                 1005             


Arg Glu  Phe Leu Phe Gln Gln  Leu Gly Met Leu Val  Ser Phe Val 
    1010                 1015                 1020             


Lys Ser  His Ile Arg Pro Tyr  Met Asp Glu Ile Val  Thr Leu Met 
    1025                 1030                 1035             


Arg Glu  Phe Trp Val Met Asn  Thr Ser Ile Gln Ser  Thr Ile Ile 
    1040                 1045                 1050             


Leu Leu  Ile Glu Gln Ile Val  Val Ala Leu Gly Gly  Glu Phe Lys 
    1055                 1060                 1065             


Leu Tyr  Leu Pro Gln Leu Ile  Pro His Met Leu Arg  Val Phe Met 
    1070                 1075                 1080             


His Asp  Asn Ser Gln Gly Arg  Ile Val Ser Ile Lys  Leu Leu Ala 
    1085                 1090                 1095             


Ala Ile  Gln Leu Phe Gly Ala  Asn Leu Asp Asp Tyr  Leu His Leu 
    1100                 1105                 1110             


Leu Leu  Pro Pro Ile Val Lys  Leu Phe Asp Ala Pro  Glu Val Pro 
    1115                 1120                 1125             


Leu Pro  Ser Arg Lys Ala Ala  Leu Glu Thr Val Asp  Arg Leu Thr 
    1130                 1135                 1140             


Glu Ser  Leu Asp Phe Thr Asp  Tyr Ala Ser Arg Ile  Ile His Pro 
    1145                 1150                 1155             


Ile Val  Arg Thr Leu Asp Gln  Ser Pro Glu Leu Arg  Ser Thr Ala 
    1160                 1165                 1170             


Met Asp  Thr Leu Ser Ser Leu  Val Phe Gln Leu Gly  Lys Lys Tyr 
    1175                 1180                 1185             


Gln Ile  Phe Ile Pro Met Val  Asn Lys Val Leu Val  Arg His Arg 
    1190                 1195                 1200             


Ile Asn  His Gln Arg Tyr Asp  Val Leu Ile Cys Arg  Ile Val Lys 
    1205                 1210                 1215             


Gly Tyr  Thr Leu Ala Asp Glu  Glu Glu Asp Pro Leu  Ile Tyr Gln 
    1220                 1225                 1230             


His Arg  Met Leu Arg Ser Ser  Gln Gly Asp Ala Leu  Ala Ser Gly 
    1235                 1240                 1245             


Pro Val  Glu Thr Gly Pro Met  Lys Lys Leu His Val  Ser Thr Ile 
    1250                 1255                 1260             


Asn Leu  Gln Lys Ala Trp Gly  Ala Ala Arg Arg Val  Ser Lys Asp 
    1265                 1270                 1275             


Asp Trp  Leu Glu Trp Leu Arg  Arg Leu Ser Leu Glu  Leu Leu Lys 
    1280                 1285                 1290             


Asp Ser  Ser Ser Pro Ser Leu  Arg Ser Cys Trp Ala  Leu Ala Gln 
    1295                 1300                 1305             


Ala Tyr  Asn Pro Met Ala Arg  Asp Leu Phe Asn Ala  Ala Phe Val 
    1310                 1315                 1320             


Ser Cys  Trp Ser Glu Leu Asn  Glu Asp Gln Gln Asp  Glu Leu Ile 
    1325                 1330                 1335             


Arg Ser  Ile Glu Leu Ala Leu  Thr Ser Gln Asp Ile  Ala Glu Val 
    1340                 1345                 1350             


Thr Gln  Thr Leu Leu Asn Leu  Ala Glu Phe Met Glu  His Ser Asp 
    1355                 1360                 1365             


Lys Gly  Pro Leu Pro Leu Arg  Asp Asp Asn Gly Ile  Val Leu Leu 
    1370                 1375                 1380             


Gly Glu  Arg Ala Ala Lys Cys  Arg Ala Tyr Ala Lys  Ala Leu His 
    1385                 1390                 1395             


Tyr Lys  Glu Leu Glu Phe Gln  Lys Gly Pro Thr Pro  Ala Ile Leu 
    1400                 1405                 1410             


Glu Ser  Leu Ile Ser Ile Asn  Asn Lys Leu Gln Gln  Pro Glu Ala 
    1415                 1420                 1425             


Ala Ser  Gly Val Leu Glu Tyr  Ala Met Lys His Phe  Gly Glu Leu 
    1430                 1435                 1440             


Glu Ile  Gln Ala Thr Trp Tyr  Glu Lys Leu His Glu  Trp Glu Asp 
    1445                 1450                 1455             


Ala Leu  Val Ala Tyr Asp Lys  Lys Met Asp Thr Asn  Lys Glu Asp 
    1460                 1465                 1470             


Pro Glu  Leu Met Leu Gly Arg  Met Arg Cys Leu Glu  Ala Leu Gly 
    1475                 1480                 1485             


Glu Trp  Gly Gln Leu His Gln  Gln Cys Cys Glu Lys  Trp Thr Leu 
    1490                 1495                 1500             


Val Asn  Asp Glu Thr Gln Ala  Lys Met Ala Arg Met  Ala Ala Ala 
    1505                 1510                 1515             


Ala Ala  Trp Gly Leu Gly Gln  Trp Asp Ser Met Glu  Glu Tyr Thr 
    1520                 1525                 1530             


Cys Met  Ile Pro Arg Asp Thr  His Asp Gly Ala Phe  Tyr Arg Ala 
    1535                 1540                 1545             


Val Leu  Ala Leu His Gln Asp  Leu Phe Ser Leu Ala  Gln Gln Cys 
    1550                 1555                 1560             


Ile Asp  Lys Ala Arg Asp Leu  Leu Asp Ala Glu Leu  Thr Ala Met 
    1565                 1570                 1575             


Ala Gly  Glu Ser Tyr Ser Arg  Ala Tyr Gly Ala Met  Val Ser Cys 
    1580                 1585                 1590             


His Met  Leu Ser Glu Leu Glu  Glu Val Ile Gln Tyr  Lys Leu Val 
    1595                 1600                 1605             


Pro Glu  Arg Arg Glu Ile Ile  Arg Gln Ile Trp Trp  Glu Arg Leu 
    1610                 1615                 1620             


Gln Gly  Cys Gln Arg Ile Val  Glu Asp Trp Gln Lys  Ile Leu Met 
    1625                 1630                 1635             


Val Arg  Ser Leu Val Val Ser  Pro His Glu Asp Met  Arg Thr Trp 
    1640                 1645                 1650             


Leu Lys  Tyr Ala Ser Leu Cys  Gly Lys Ser Gly Arg  Leu Ala Leu 
    1655                 1660                 1665             


Ala His  Lys Thr Leu Val Leu  Leu Leu Gly Val Asp  Pro Ser Arg 
    1670                 1675                 1680             


Gln Leu  Asp His Pro Leu Pro  Thr Ala His Pro Gln  Val Thr Tyr 
    1685                 1690                 1695             


Ala Tyr  Met Lys Asn Met Trp  Lys Ser Ala Arg Lys  Ile Asp Ala 
    1700                 1705                 1710             


Phe Gln  His Met Gln His Phe  Val Gln Thr Met Gln  Gln Gln Ala 
    1715                 1720                 1725             


Gln His  Ala Ile Ala Thr Glu  Asp Gln Gln His Lys  Gln Glu Leu 
    1730                 1735                 1740             


His Lys  Leu Met Ala Arg Cys  Phe Leu Lys Leu Gly  Glu Trp Gln 
    1745                 1750                 1755             


Leu Asn  Leu Gln Gly Ile Asn  Glu Ser Thr Ile Pro  Lys Val Leu 
    1760                 1765                 1770             


Gln Tyr  Tyr Ser Ala Ala Thr  Glu His Asp Arg Ser  Trp Tyr Lys 
    1775                 1780                 1785             


Ala Trp  His Ala Trp Ala Val  Met Asn Phe Glu Ala  Val Leu His 
    1790                 1795                 1800             


Tyr Lys  His Gln Asn Gln Ala  Arg Asp Glu Lys Lys  Lys Leu Arg 
    1805                 1810                 1815             


His Ala  Ser Gly Ala Asn Ile  Thr Asn Ala Thr Thr  Ala Ala Thr 
    1820                 1825                 1830             


Thr Ala  Ala Ser Ala Ala Ala  Ala Thr Ser Thr Glu  Gly Ser Asn 
    1835                 1840                 1845             


Ser Glu  Ser Glu Ala Glu Ser  Asn Glu Asn Ser Pro  Thr Pro Ser 
    1850                 1855                 1860             


Pro Leu  Gln Lys Lys Val Thr  Glu Asp Leu Ser Lys  Thr Leu Leu 
    1865                 1870                 1875             


Leu Tyr  Thr Val Pro Ala Val  Gln Gly Phe Phe Arg  Ser Ile Ser 
    1880                 1885                 1890             


Leu Ser  Arg Gly Asn Asn Leu  Gln Asp Thr Leu Arg  Val Leu Thr 
    1895                 1900                 1905             


Leu Trp  Phe Asp Tyr Gly His  Trp Pro Asp Val Asn  Glu Ala Leu 
    1910                 1915                 1920             


Val Glu  Gly Val Lys Ala Ile  Gln Ile Asp Thr Trp  Leu Gln Val 
    1925                 1930                 1935             


Ile Pro  Gln Leu Ile Ala Arg  Ile Asp Thr Pro Arg  Pro Leu Val 
    1940                 1945                 1950             


Gly Arg  Leu Ile His Gln Leu  Leu Thr Asp Ile Gly  Arg Tyr His 
    1955                 1960                 1965             


Pro Gln  Ala Leu Ile Tyr Pro  Leu Thr Val Ala Ser  Lys Ser Thr 
    1970                 1975                 1980             


Thr Thr  Ala Arg His Asn Ala  Ala Asn Lys Ile Leu  Lys Asn Met 
    1985                 1990                 1995             


Cys Glu  His Ser Asn Thr Leu  Val Gln Gln Ala Met  Met Val Ser 
    2000                 2005                 2010             


Glu Glu  Leu Ile Arg Val Ala  Ile Leu Trp His Glu  Met Trp His 
    2015                 2020                 2025             


Glu Gly  Leu Glu Glu Ala Ser  Arg Leu Tyr Phe Gly  Glu Arg Asn 
    2030                 2035                 2040             


Val Lys  Gly Met Phe Glu Val  Leu Glu Pro Leu His  Ala Met Met 
    2045                 2050                 2055             


Glu Arg  Gly Pro Gln Thr Leu  Lys Glu Thr Ser Phe  Asn Gln Ala 
    2060                 2065                 2070             


Tyr Gly  Arg Asp Leu Met Glu  Ala Gln Glu Trp Cys  Arg Lys Tyr 
    2075                 2080                 2085             


Met Lys  Ser Gly Asn Val Lys  Asp Leu Thr Gln Ala  Trp Asp Leu 
    2090                 2095                 2100             


Tyr Tyr  His Val Phe Arg Arg  Ile Ser Lys Gln Leu  Pro Gln Leu 
    2105                 2110                 2115             


Thr Ser  Leu Glu Leu Gln Tyr  Val Ser Pro Lys Leu  Leu Met Cys 
    2120                 2125                 2130             


Arg Asp  Leu Glu Leu Ala Val  Pro Gly Thr Tyr Asp  Pro Asn Gln 
    2135                 2140                 2145             


Pro Ile  Ile Arg Ile Gln Ser  Ile Ala Pro Ser Leu  Gln Val Ile 
    2150                 2155                 2160             


Thr Ser  Lys Gln Arg Pro Arg  Lys Leu Thr Leu Met  Gly Ser Asn 
    2165                 2170                 2175             


Gly His  Glu Phe Val Phe Leu  Leu Lys Gly His Glu  Asp Leu Arg 
    2180                 2185                 2190             


Gln Asp  Glu Arg Val Met Gln  Leu Phe Gly Leu Val  Asn Thr Leu 
    2195                 2200                 2205             


Leu Ala  Asn Asp Pro Thr Ser  Leu Arg Lys Asn Leu  Ser Ile Gln 
    2210                 2215                 2220             


Arg Tyr  Ala Val Ile Pro Leu  Ser Thr Asn Ser Gly  Leu Ile Gly 
    2225                 2230                 2235             


Trp Val  Pro His Cys Asp Thr  Leu His Ala Leu Ile  Arg Asp Tyr 
    2240                 2245                 2250             


Arg Glu  Lys Lys Lys Ile Leu  Leu Asn Ile Glu His  Arg Ile Met 
    2255                 2260                 2265             


Leu Arg  Met Ala Pro Asp Tyr  Asp His Leu Thr Leu  Met Gln Lys 
    2270                 2275                 2280             


Val Glu  Val Phe Glu His Ala  Val Asn Asn Thr Ala  Gly Asp Asp 
    2285                 2290                 2295             


Leu Ala  Lys Leu Leu Trp Leu  Lys Ser Pro Ser Ser  Glu Val Trp 
    2300                 2305                 2310             


Phe Asp  Arg Arg Thr Asn Tyr  Thr Arg Ser Leu Ala  Val Met Ser 
    2315                 2320                 2325             


Met Val  Gly Tyr Ile Leu Gly  Leu Gly Asp Arg His  Pro Ser Asn 
    2330                 2335                 2340             


Leu Met  Leu Asp Arg Leu Ser  Gly Lys Ile Leu His  Ile Asp Phe 
    2345                 2350                 2355             


Gly Asp  Cys Phe Glu Val Ala  Met Thr Arg Glu Lys  Phe Pro Glu 
    2360                 2365                 2370             


Lys Ile  Pro Phe Arg Leu Thr  Arg Met Leu Thr Asn  Ala Met Glu 
    2375                 2380                 2385             


Val Thr  Gly Leu Asp Gly Asn  Tyr Arg Thr Thr Cys  His Thr Val 
    2390                 2395                 2400             


Met Glu  Val Leu Arg Glu His  Lys Asp Ser Val Met  Ala Val Leu 
    2405                 2410                 2415             


Glu Ala  Phe Val Tyr Asp Pro  Leu Leu Asn Trp Arg  Leu Met Asp 
    2420                 2425                 2430             


Thr Asn  Thr Lys Gly Asn Lys  Arg Ser Arg Thr Arg  Thr Asp Ser 
    2435                 2440                 2445             


Tyr Ser  Ala Gly Gln Ser Val  Glu Ile Leu Asp Gly  Val Glu Leu 
    2450                 2455                 2460             


Gly Glu  Pro Ala His Lys Lys  Ala Gly Thr Thr Val  Pro Glu Ser 
    2465                 2470                 2475             


Ile His  Ser Phe Ile Gly Asp  Gly Leu Val Lys Pro  Glu Ala Leu 
    2480                 2485                 2490             


Asn Lys  Lys Ala Ile Gln Ile  Ile Asn Arg Val Arg  Asp Lys Leu 
    2495                 2500                 2505             


Thr Gly  Arg Asp Phe Ser His  Asp Asp Thr Leu Asp  Val Pro Thr 
    2510                 2515                 2520             


Gln Val  Glu Leu Leu Ile Lys  Gln Ala Thr Ser His  Glu Asn Leu 
    2525                 2530                 2535             


Cys Gln  Cys Tyr Ile Gly Trp  Cys Pro Phe Trp 
    2540                 2545                 


<210>  9
<211>  1161
<212>  PRT
<213>  Mus musculus

<400>  9

Met Ala Gln Leu Ala Asn Ile Gly Glu Leu Leu Ser Met Leu Asp Ser 
1               5                   10                  15      


Ser Thr Leu Gly Val Arg Asp Asp Val Thr Ala Ile Phe Lys Glu Ser 
            20                  25                  30          


Leu Asn Ser Glu Arg Gly Pro Met Leu Val Asn Thr Leu Val Asp Tyr 
        35                  40                  45              


Tyr Leu Glu Thr Asn Ser Gln Pro Val Leu His Ile Leu Thr Thr Leu 
    50                  55                  60                  


Gln Glu Pro His Asp Lys His Leu Leu Asp Lys Ile Asn Glu Tyr Val 
65                  70                  75                  80  


Gly Lys Ala Ala Thr Arg Leu Ser Ile Leu Ser Leu Leu Gly His Val 
                85                  90                  95      


Val Arg Leu Gln Pro Ser Trp Lys His Lys Leu Ser Gln Ala Pro Leu 
            100                 105                 110         


Leu Pro Ser Leu Leu Lys Cys Leu Lys Met Asp Thr Asp Val Val Val 
        115                 120                 125             


Leu Thr Thr Gly Val Leu Val Leu Ile Thr Met Leu Pro Met Ile Pro 
    130                 135                 140                 


Gln Ser Gly Lys Gln His Leu Leu Asp Phe Phe Asp Ile Phe Gly Arg 
145                 150                 155                 160 


Leu Ser Ser Trp Cys Leu Lys Lys Pro Gly His Val Thr Glu Val Tyr 
                165                 170                 175     


Leu Val His Leu His Ala Ser Val Tyr Ala Leu Phe His Arg Leu Tyr 
            180                 185                 190         


Gly Met Tyr Pro Cys Asn Phe Val Ser Phe Leu Arg Ser His Tyr Ser 
        195                 200                 205             


Met Lys Glu Asn Val Glu Thr Phe Glu Glu Val Val Lys Pro Met Met 
    210                 215                 220                 


Glu His Val Arg Ile His Pro Glu Leu Val Thr Gly Ser Lys Asp His 
225                 230                 235                 240 


Glu Leu Asp Pro Arg Arg Trp Lys Thr Leu Glu Thr His Asp Val Val 
                245                 250                 255     


Ile Glu Cys Ala Lys Ile Ser Leu Asp Pro Thr Glu Ala Ser Tyr Glu 
            260                 265                 270         


Asp Gly Tyr Ser Val Ser His Gln Leu Ser Ala Cys Phe Pro Tyr Arg 
        275                 280                 285             


Ser Ala Asp Val Thr Thr Ser Pro Tyr Val Asp Thr Gln Asn Ser Tyr 
    290                 295                 300                 


Gly Gly Ser Thr Ser Thr Pro Ser Ser Ser Ser Arg Leu Met Leu Phe 
305                 310                 315                 320 


Ser Pro Pro Gly Gln Leu Pro Gln Ser Leu Ser Ser Pro Ser Thr Arg 
                325                 330                 335     


Leu Leu Pro Glu Pro Leu Gln Ala Ser Leu Trp Ser Pro Ser Ala Val 
            340                 345                 350         


Cys Gly Met Thr Thr Pro Pro Thr Ser Pro Gly Asn Val Pro Ala Asp 
        355                 360                 365             


Leu Ser His Pro Tyr Ser Lys Ala Phe Gly Thr Thr Ala Gly Gly Lys 
    370                 375                 380                 


Gly Thr Pro Ser Gly Thr Pro Ala Thr Ser Pro Pro Pro Ala Pro Pro 
385                 390                 395                 400 


Cys Pro Gln Asp Asp Cys Val His Gly Ser Ala Ala Gln Ala Ser Ala 
                405                 410                 415     


Thr Ala Pro Arg Lys Glu Glu Arg Ala Asp Ser Ser Arg Pro Tyr Leu 
            420                 425                 430         


His Arg Gln Ser Asn Asp Arg Gly Leu Glu Asp Pro Pro Gly Ser Lys 
        435                 440                 445             


Gly Ser Val Thr Leu Arg Asn Leu Pro Asp Phe Leu Gly Asp Leu Ala 
    450                 455                 460                 


Ser Glu Glu Asp Ser Ile Glu Lys Asp Lys Glu Glu Ala Ala Ile Ser 
465                 470                 475                 480 


Lys Glu Leu Ser Glu Ile Thr Thr Ala Glu Ala Asp Pro Val Val Pro 
                485                 490                 495     


Arg Gly Gly Phe Asp Ser Pro Phe Tyr Arg Asp Ser Leu Ser Gly Ser 
            500                 505                 510         


Gln Arg Lys Thr His Ser Ala Ala Ser Gly Thr Gln Gly Ser Ser Val 
        515                 520                 525             


Asn Pro Glu Pro Leu His Ser Ser Leu Asp Lys His Gly Pro Asp Thr 
    530                 535                 540                 


Pro Lys Gln Ala Phe Thr Pro Ile Asp Pro Pro Ser Gly Ser Ala Asp 
545                 550                 555                 560 


Val Ser Pro Ala Gly Asp Arg Asp Arg Gln Thr Ser Leu Glu Thr Ser 
                565                 570                 575     


Ile Leu Thr Pro Ser Pro Cys Lys Ile Pro Pro Gln Arg Gly Val Ser 
            580                 585                 590         


Phe Gly Ser Gly Gln Leu Pro Pro Tyr Asp His Leu Phe Glu Val Ala 
        595                 600                 605             


Leu Pro Lys Thr Ala Cys His Phe Val Ser Lys Lys Thr Glu Glu Leu 
    610                 615                 620                 


Leu Lys Lys Val Lys Gly Asn Pro Glu Glu Asp Cys Val Pro Ser Thr 
625                 630                 635                 640 


Ser Pro Met Glu Val Leu Asp Arg Leu Ile Glu Gln Gly Ala Gly Ala 
                645                 650                 655     


His Ser Lys Glu Leu Ser Arg Leu Ser Leu Pro Ser Lys Ser Val Asp 
            660                 665                 670         


Trp Thr His Phe Gly Gly Ser Pro Pro Ser Asp Glu Leu Arg Thr Leu 
        675                 680                 685             


Arg Asp Gln Leu Leu Leu Leu His Asn Gln Leu Leu Tyr Glu Arg Phe 
    690                 695                 700                 


Lys Arg Gln Gln His Ala Leu Arg Asn Arg Arg Leu Leu Arg Lys Val 
705                 710                 715                 720 


Ile Arg Ala Ala Ala Leu Glu Glu His Asn Ala Ala Met Lys Asp Gln 
                725                 730                 735     


Leu Lys Leu Gln Glu Lys Asp Ile Gln Met Trp Lys Val Ser Leu Gln 
            740                 745                 750         


Lys Glu Gln Ala Arg Tyr Ser Gln Leu Gln Glu Gln Arg Asp Thr Met 
        755                 760                 765             


Val Thr Gln Leu His Ser Gln Ile Arg Gln Leu Gln His Asp Arg Glu 
    770                 775                 780                 


Glu Phe Tyr Asn Gln Ser Gln Glu Leu Gln Thr Lys Leu Glu Asp Cys 
785                 790                 795                 800 


Arg Asn Met Ile Ala Glu Leu Arg Val Glu Leu Lys Lys Ala Asn Asn 
                805                 810                 815     


Lys Val Cys His Thr Glu Leu Leu Leu Ser Gln Val Ser Gln Lys Leu 
            820                 825                 830         


Ser Asn Ser Glu Ser Val Gln Gln Gln Met Glu Phe Leu Asn Arg Gln 
        835                 840                 845             


Leu Leu Val Leu Gly Glu Val Asn Glu Leu Tyr Leu Glu Gln Leu Gln 
    850                 855                 860                 


Ser Lys His Pro Asp Thr Thr Lys Glu Val Glu Met Met Lys Thr Ala 
865                 870                 875                 880 


Tyr Arg Lys Glu Leu Glu Lys Asn Arg Ser His Leu Leu Gln Gln Asn 
                885                 890                 895     


Gln Arg Leu Asp Ala Ser Gln Arg Arg Val Leu Glu Leu Glu Ser Leu 
            900                 905                 910         


Leu Ala Lys Lys Asp His Leu Leu Leu Glu Gln Lys Lys Tyr Leu Glu 
        915                 920                 925             


Asp Val Lys Ser Gln Ala Ser Gly Gln Leu Leu Ala Ala Glu Ser Arg 
    930                 935                 940                 


Tyr Glu Ala Gln Arg Lys Ile Thr Arg Val Leu Glu Leu Glu Ile Leu 
945                 950                 955                 960 


Asp Leu Tyr Gly Arg Leu Glu Lys Asp Gly Arg Leu Arg Lys Leu Glu 
                965                 970                 975     


Glu Asp Arg Ala Glu Ala Ala Glu Ala Ala Glu Glu Arg Leu Asp Cys 
            980                 985                 990         


Cys Ser Asp Gly Cys Thr Asp Ser  Leu Val Gly His Asn  Glu Glu Ala 
        995                 1000                 1005             


Ser Gly  His Asn Gly Glu Thr  Arg Thr Ser Arg Pro  Gly Gly Thr 
    1010                 1015                 1020             


Arg Ala  Ser Cys Gly Gly Arg  Val Thr Gly Gly Ser  Ser Ser Ser 
    1025                 1030                 1035             


Ser Ser  Glu Leu Ser Thr Pro  Glu Lys Pro Pro Ser  Gln Arg Phe 
    1040                 1045                 1050             


Ser Ser  Arg Trp Glu Pro Ala  Leu Gly Glu Pro Ser  Ser Ser Ile 
    1055                 1060                 1065             


Pro Thr  Thr Val Gly Ser Leu  Pro Ser Ser Lys Ser  Phe Leu Gly 
    1070                 1075                 1080             


Met Lys  Ala Arg Glu Leu Phe  Arg Asn Lys Ser Glu  Ser Gln Cys 
    1085                 1090                 1095             


Asp Glu  Asp Ser Val Thr Met  Ser Ser Ser Ser Leu  Ser Glu Thr 
    1100                 1105                 1110             


Leu Lys  Thr Glu Leu Gly Lys  Asp Ser Gly Thr Glu  Asn Lys Thr 
    1115                 1120                 1125             


Ser Leu  Ser Leu Asp Ala Pro  His Pro Ser Ser Pro  Asn Ser Asp 
    1130                 1135                 1140             


Asn Val  Gly Gln Leu His Ile  Met Asp Tyr Asn Glu  Thr His Pro 
    1145                 1150                 1155             


Glu His  Ser 
    1160     


<210>  10
<211>  1740
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
1               5                   10                  15      


Ile Leu Leu Gly Leu Gly Thr Pro Arg Pro Asn Pro Arg Ser Ala Glu 
            20                  25                  30          


Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
        35                  40                  45              


Ser Met Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
    50                  55                  60                  


Cys Glu Val Ala Lys Thr Lys Lys Phe Glu Glu His Ala Val Glu Ala 
65                  70                  75                  80  


Leu Trp Lys Ala Val Ala Asp Leu Leu Gln Pro Glu Arg Pro Leu Glu 
                85                  90                  95      


Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
            100                 105                 110         


Gly Glu Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
        115                 120                 125             


Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
    130                 135                 140                 


Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
145                 150                 155                 160 


Ala Asp Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                165                 170                 175     


Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
            180                 185                 190         


Glu Tyr Ile Ala Arg Met Val Gln Met Ile Cys Leu Leu Cys Val Arg 
        195                 200                 205             


Thr Ala Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
    210                 215                 220                 


Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
225                 230                 235                 240 


Val Thr Leu Cys Arg Thr Ile Asn Val Lys Glu Leu Cys Glu Pro Cys 
                245                 250                 255     


Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
            260                 265                 270         


Ile Tyr Asn Met Cys His Leu Met Glu Asp Arg Ala Tyr Met Glu Asp 
        275                 280                 285             


Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
    290                 295                 300                 


Gly Ala His Arg Leu Tyr Ser Leu Arg Asn Ser Pro Thr Ser Val Leu 
305                 310                 315                 320 


Pro Ser Phe Tyr Gln Ala Met Ala Cys Pro Asn Glu Val Val Ser Tyr 
                325                 330                 335     


Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
            340                 345                 350         


Leu Gln Val Val Ala Trp Asp Ile Leu Leu Asn Ile Ile Glu Arg Leu 
        355                 360                 365             


Leu Gln Gln Leu Gln Thr Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
    370                 375                 380                 


His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
385                 390                 395                 400 


His Gly Ser Gln Glu Arg Tyr Phe Glu Leu Val Glu Arg Cys Ala Asp 
                405                 410                 415     


Gln Arg Pro Glu Ser Ser Leu Leu Asn Leu Ile Ser Tyr Arg Ala Gln 
            420                 425                 430         


Ser Ile His Pro Ala Lys Asp Gly Trp Ile Gln Asn Leu Gln Ala Leu 
        435                 440                 445             


Met Glu Arg Phe Phe Arg Ser Glu Ser Arg Gly Ala Val Arg Ile Lys 
    450                 455                 460                 


Val Leu Asp Val Leu Ser Phe Val Leu Leu Ile Asn Arg Gln Phe Tyr 
465                 470                 475                 480 


Glu Glu Glu Leu Ile Asn Ser Val Val Ile Ser Gln Leu Ser His Ile 
                485                 490                 495     


Pro Glu Asp Lys Asp His Gln Val Arg Lys Leu Ala Thr Gln Leu Leu 
            500                 505                 510         


Val Asp Leu Ala Glu Gly Cys His Thr His His Phe Asn Ser Leu Leu 
        515                 520                 525             


Asp Ile Ile Glu Lys Val Met Ala Arg Ser Leu Ser Pro Pro Pro Glu 
    530                 535                 540                 


Leu Glu Glu Arg Asp Val Ala Ala Tyr Ser Ala Ser Leu Glu Asp Val 
545                 550                 555                 560 


Lys Thr Ala Val Leu Gly Leu Leu Val Ile Leu Gln Thr Lys Leu Tyr 
                565                 570                 575     


Thr Leu Pro Ala Ser His Ala Thr Arg Val Tyr Glu Met Leu Val Ser 
            580                 585                 590         


His Ile Gln Leu His Tyr Lys His Ser Tyr Thr Leu Pro Ile Ala Ser 
        595                 600                 605             


Ser Ile Arg Leu Gln Ala Phe Asp Phe Leu Leu Leu Leu Arg Ala Asp 
    610                 615                 620                 


Ser Leu His Arg Leu Gly Leu Pro Asn Lys Asp Gly Val Val Arg Phe 
625                 630                 635                 640 


Ser Pro Tyr Cys Val Cys Asp Tyr Met Glu Pro Glu Arg Gly Ser Glu 
                645                 650                 655     


Lys Lys Thr Ser Gly Pro Leu Ser Pro Pro Thr Gly Pro Pro Gly Pro 
            660                 665                 670         


Ala Pro Ala Gly Pro Ala Val Arg Leu Gly Ser Val Pro Tyr Ser Leu 
        675                 680                 685             


Leu Phe Arg Val Leu Leu Gln Cys Leu Lys Gln Glu Ser Asp Trp Lys 
    690                 695                 700                 


Val Leu Lys Leu Val Leu Gly Arg Leu Pro Glu Ser Leu Arg Tyr Lys 
705                 710                 715                 720 


Val Leu Ile Phe Thr Ser Pro Cys Ser Val Asp Gln Leu Cys Ser Ala 
                725                 730                 735     


Leu Cys Ser Met Leu Ser Gly Pro Lys Thr Leu Glu Arg Leu Arg Gly 
            740                 745                 750         


Ala Pro Glu Gly Phe Ser Arg Thr Asp Leu His Leu Ala Val Val Pro 
        755                 760                 765             


Val Leu Thr Ala Leu Ile Ser Tyr His Asn Tyr Leu Asp Lys Thr Lys 
    770                 775                 780                 


Gln Arg Glu Met Val Tyr Cys Leu Glu Gln Gly Leu Ile His Arg Cys 
785                 790                 795                 800 


Ala Ser Gln Cys Val Val Ala Leu Ser Ile Cys Ser Val Glu Met Pro 
                805                 810                 815     


Asp Ile Ile Ile Lys Ala Leu Pro Val Leu Val Val Lys Leu Thr His 
            820                 825                 830         


Ile Ser Ala Thr Ala Ser Met Ala Val Pro Leu Leu Glu Phe Leu Ser 
        835                 840                 845             


Thr Leu Ala Arg Leu Pro His Leu Tyr Arg Asn Phe Ala Ala Glu Gln 
    850                 855                 860                 


Tyr Ala Ser Val Phe Ala Ile Ser Leu Pro Tyr Thr Asn Pro Ser Lys 
865                 870                 875                 880 


Phe Asn Gln Tyr Ile Val Cys Leu Ala His His Val Ile Ala Met Trp 
                885                 890                 895     


Phe Ile Arg Cys Arg Leu Pro Phe Arg Lys Asp Phe Val Pro Phe Ile 
            900                 905                 910         


Thr Lys Gly Leu Arg Ser Asn Val Leu Leu Ser Phe Asp Asp Thr Pro 
        915                 920                 925             


Glu Lys Asp Ser Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro 
    930                 935                 940                 


Lys Arg Ile Gln Thr Ser Leu Thr Ser Ala Ser Leu Gly Ser Ala Asp 
945                 950                 955                 960 


Glu Asn Ser Val Ala Gln Ala Asp Asp Ser Leu Lys Asn Leu His Leu 
                965                 970                 975     


Glu Leu Thr Glu Thr Cys Leu Asp Met Met Ala Arg Tyr Val Phe Ser 
            980                 985                 990         


Asn Phe Thr Ala Val Pro Lys Arg  Ser Pro Val Gly Glu  Phe Leu Leu 
        995                 1000                 1005             


Ala Gly  Gly Arg Thr Lys Thr  Trp Leu Val Gly Asn  Lys Leu Val 
    1010                 1015                 1020             


Thr Val  Thr Thr Ser Val Gly  Thr Gly Thr Arg Ser  Leu Leu Gly 
    1025                 1030                 1035             


Leu Asp  Ser Gly Glu Leu Gln  Ser Gly Pro Glu Ser  Ser Ser Ser 
    1040                 1045                 1050             


Pro Gly  Val His Val Arg Gln  Thr Lys Glu Ala Pro  Ala Lys Leu 
    1055                 1060                 1065             


Glu Ser  Gln Ala Gly Gln Gln  Val Ser Arg Gly Ala  Arg Asp Arg 
    1070                 1075                 1080             


Val Arg  Ser Met Ser Gly Gly  His Gly Leu Arg Val  Gly Ala Leu 
    1085                 1090                 1095             


Asp Val  Pro Ala Ser Gln Phe  Leu Gly Ser Ala Thr  Ser Pro Gly 
    1100                 1105                 1110             


Pro Arg  Thr Ala Pro Ala Ala  Lys Pro Glu Lys Ala  Ser Ala Gly 
    1115                 1120                 1125             


Thr Arg  Val Pro Val Gln Glu  Lys Thr Asn Leu Ala  Ala Tyr Val 
    1130                 1135                 1140             


Pro Leu  Leu Thr Gln Gly Trp  Ala Glu Ile Leu Val  Arg Arg Pro 
    1145                 1150                 1155             


Thr Gly  Asn Thr Ser Trp Leu  Met Ser Leu Glu Asn  Pro Leu Ser 
    1160                 1165                 1170             


Pro Phe  Ser Ser Asp Ile Asn  Asn Met Pro Leu Gln  Glu Leu Ser 
    1175                 1180                 1185             


Asn Ala  Leu Met Ala Ala Glu  Arg Phe Lys Glu His  Arg Asp Thr 
    1190                 1195                 1200             


Ala Leu  Tyr Lys Ser Leu Ser  Val Pro Ala Ala Ser  Thr Ala Lys 
    1205                 1210                 1215             


Pro Pro  Pro Leu Pro Arg Ser  Asn Thr Asp Ser Ala  Val Val Met 
    1220                 1225                 1230             


Glu Glu  Gly Ser Pro Gly Glu  Val Pro Val Leu Val  Glu Pro Pro 
    1235                 1240                 1245             


Gly Leu  Glu Asp Val Glu Ala  Ala Leu Gly Met Asp  Arg Arg Thr 
    1250                 1255                 1260             


Asp Ala  Tyr Ser Arg Ser Ser  Ser Val Ser Ser Gln  Glu Glu Lys 
    1265                 1270                 1275             


Ser Leu  His Ala Glu Glu Leu  Val Gly Arg Gly Ile  Pro Ile Glu 
    1280                 1285                 1290             


Arg Val  Val Ser Ser Glu Gly  Gly Arg Pro Ser Val  Asp Leu Ser 
    1295                 1300                 1305             


Phe Gln  Pro Ser Gln Pro Leu  Ser Lys Ser Ser Ser  Ser Pro Glu 
    1310                 1315                 1320             


Leu Gln  Thr Leu Gln Asp Ile  Leu Gly Asp Pro Gly  Asp Lys Ala 
    1325                 1330                 1335             


Asp Val  Gly Arg Leu Ser Pro  Glu Val Lys Ala Arg  Ser Gln Ser 
    1340                 1345                 1350             


Gly Thr  Leu Asp Gly Glu Ser  Ala Ala Trp Ser Ala  Ser Gly Glu 
    1355                 1360                 1365             


Asp Ser  Arg Gly Gln Pro Glu  Gly Pro Leu Pro Ser  Ser Ser Pro 
    1370                 1375                 1380             


Arg Ser  Pro Ser Gly Leu Arg  Pro Arg Gly Tyr Thr  Ile Ser Asp 
    1385                 1390                 1395             


Ser Ala  Pro Ser Arg Arg Gly  Lys Arg Val Glu Arg  Asp Ala Leu 
    1400                 1405                 1410             


Lys Ser  Arg Ala Thr Ala Ser  Asn Ala Glu Lys Val  Pro Gly Ile 
    1415                 1420                 1425             


Asn Pro  Ser Phe Val Phe Leu  Gln Leu Tyr His Ser  Pro Phe Phe 
    1430                 1435                 1440             


Gly Asp  Glu Ser Asn Lys Pro  Ile Leu Leu Pro Asn  Glu Ser Gln 
    1445                 1450                 1455             


Ser Phe  Glu Arg Ser Val Gln  Leu Leu Asp Gln Ile  Pro Ser Tyr 
    1460                 1465                 1470             


Asp Thr  His Lys Ile Ala Val  Leu Tyr Val Gly Glu  Gly Gln Ser 
    1475                 1480                 1485             


Asn Ser  Glu Leu Ala Ile Leu  Ser Asn Glu His Gly  Ser Tyr Arg 
    1490                 1495                 1500             


Tyr Thr  Glu Phe Leu Thr Gly  Leu Gly Arg Leu Ile  Glu Leu Lys 
    1505                 1510                 1515             


Asp Cys  Gln Pro Asp Lys Val  Tyr Leu Gly Gly Leu  Asp Val Cys 
    1520                 1525                 1530             


Gly Glu  Asp Gly Gln Phe Thr  Tyr Cys Trp His Asp  Asp Ile Met 
    1535                 1540                 1545             


Gln Ala  Val Phe His Ile Ala  Thr Leu Met Pro Thr  Lys Asp Val 
    1550                 1555                 1560             


Asp Lys  His Arg Cys Asp Lys  Lys Arg His Leu Gly  Asn Asp Phe 
    1565                 1570                 1575             


Val Ser  Ile Val Tyr Asn Asp  Ser Gly Glu Asp Phe  Lys Leu Gly 
    1580                 1585                 1590             


Thr Ile  Lys Gly Gln Phe Asn  Phe Val His Val Ile  Val Thr Pro 
    1595                 1600                 1605             


Leu Asp  Tyr Glu Cys Asn Leu  Val Ser Leu Gln Cys  Arg Lys Asp 
    1610                 1615                 1620             


Met Glu  Gly Leu Val Asp Thr  Ser Val Ala Lys Ile  Val Ser Asp 
    1625                 1630                 1635             


Arg Asn  Leu Pro Phe Val Ala  Arg Gln Met Ala Leu  His Ala Asn 
    1640                 1645                 1650             


Met Ala  Ser Gln Val His His  Ser Arg Ser Asn Pro  Thr Asp Ile 
    1655                 1660                 1665             


Tyr Pro  Ser Lys Trp Ile Ala  Arg Leu Arg His Ile  Lys Arg Leu 
    1670                 1675                 1680             


Arg Gln  Arg Ile Cys Glu Glu  Ala Ala Tyr Ser Asn  Pro Ser Leu 
    1685                 1690                 1695             


Pro Leu  Val His Pro Pro Ser  His Ser Lys Ala Pro  Ala Gln Thr 
    1700                 1705                 1710             


Pro Ala  Glu Pro Thr Pro Gly  Tyr Glu Val Gly Gln  Arg Lys Arg 
    1715                 1720                 1725             


Leu Ile  Ser Ser Val Glu Asp  Phe Thr Glu Phe Val  
    1730                 1735                 1740 


<210>  11
<211>  501
<212>  PRT
<213>  Mus musculus

<400>  11

Met Ala Ala Ala Ala Ala Thr Ala Ala Ala Ala Ala Ala Pro Ser Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Glu Glu Glu Arg Leu Glu Glu Lys Ser Glu Asp 
            20                  25                  30          


Gln Asp Leu Gln Gly Leu Arg Asp Lys Pro Leu Lys Phe Lys Lys Ala 
        35                  40                  45              


Lys Lys Asp Lys Lys Glu Asp Lys Glu Gly Lys His Glu Pro Leu Gln 
    50                  55                  60                  


Pro Ser Ala His His Ser Ala Glu Pro Ala Glu Ala Gly Lys Ala Glu 
65                  70                  75                  80  


Thr Ser Glu Ser Ser Gly Ser Ala Pro Ala Val Pro Glu Ala Ser Ala 
                85                  90                  95      


Ser Pro Lys Gln Arg Arg Ser Ile Ile Arg Asp Arg Gly Pro Met Tyr 
            100                 105                 110         


Asp Asp Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg 
        115                 120                 125             


Lys Ser Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr Leu Ile Asn Pro 
    130                 135                 140                 


Gln Gly Lys Ala Phe Arg Ser Lys Val Glu Leu Ile Ala Tyr Phe Glu 
145                 150                 155                 160 


Lys Val Gly Asp Thr Ser Leu Asp Pro Asn Asp Phe Asp Phe Thr Val 
                165                 170                 175     


Thr Gly Arg Gly Ser Pro Ser Arg Arg Glu Gln Lys Pro Pro Lys Lys 
            180                 185                 190         


Pro Lys Ser Pro Lys Ala Pro Gly Thr Gly Arg Gly Arg Gly Arg Pro 
        195                 200                 205             


Lys Gly Ser Gly Thr Gly Arg Pro Lys Ala Ala Ala Ser Glu Gly Val 
    210                 215                 220                 


Gln Val Lys Arg Val Leu Glu Lys Ser Pro Gly Lys Leu Val Val Lys 
225                 230                 235                 240 


Met Pro Phe Gln Ala Ser Pro Gly Gly Lys Gly Glu Gly Gly Gly Ala 
                245                 250                 255     


Thr Thr Ser Ala Gln Val Met Val Ile Lys Arg Pro Gly Arg Lys Arg 
            260                 265                 270         


Lys Ala Glu Ala Asp Pro Gln Ala Ile Pro Lys Lys Arg Gly Arg Lys 
        275                 280                 285             


Pro Gly Ser Val Val Ala Ala Ala Ala Ala Glu Ala Lys Lys Lys Ala 
    290                 295                 300                 


Val Lys Glu Ser Ser Ile Arg Ser Val His Glu Thr Val Leu Pro Ile 
305                 310                 315                 320 


Lys Lys Arg Lys Thr Arg Glu Thr Val Ser Ile Glu Val Lys Glu Val 
                325                 330                 335     


Val Lys Pro Leu Leu Val Ser Thr Leu Gly Glu Lys Ser Gly Lys Gly 
            340                 345                 350         


Leu Lys Thr Cys Lys Ser Pro Gly Arg Lys Ser Lys Glu Ser Ser Pro 
        355                 360                 365             


Lys Gly Arg Ser Ser Ser Ala Ser Ser Pro Pro Lys Lys Glu His His 
    370                 375                 380                 


His His His His His Ser Glu Ser Thr Lys Ala Pro Met Pro Leu Leu 
385                 390                 395                 400 


Pro Ser Pro Pro Pro Pro Glu Pro Glu Ser Ser Glu Asp Pro Ile Ser 
                405                 410                 415     


Pro Pro Glu Pro Gln Asp Leu Ser Ser Ser Ile Cys Lys Glu Glu Lys 
            420                 425                 430         


Met Pro Arg Gly Gly Ser Leu Glu Ser Asp Gly Cys Pro Lys Glu Pro 
        435                 440                 445             


Ala Lys Thr Gln Pro Met Val Ala Thr Thr Thr Thr Val Ala Glu Lys 
    450                 455                 460                 


Tyr Lys His Arg Gly Glu Gly Glu Arg Lys Asp Ile Val Ser Ser Ser 
465                 470                 475                 480 


Met Pro Arg Pro Asn Arg Glu Glu Pro Val Asp Ser Arg Thr Pro Val 
                485                 490                 495     


Thr Glu Arg Val Ser 
            500     


<210>  12
<211>  403
<212>  PRT
<213>  Mus musculus

<400>  12

Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
1               5                   10                  15      


Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
            20                  25                  30          


Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
        35                  40                  45              


Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
    50                  55                  60                  


Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
65                  70                  75                  80  


Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                85                  90                  95      


Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
            100                 105                 110         


Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
        115                 120                 125             


Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
    130                 135                 140                 


Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
145                 150                 155                 160 


Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                165                 170                 175     


Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
            180                 185                 190         


Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
        195                 200                 205             


Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
    210                 215                 220                 


Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 
225                 230                 235                 240 


Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                245                 250                 255     


Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
            260                 265                 270         


Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
        275                 280                 285             


Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
    290                 295                 300                 


Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
305                 310                 315                 320 


Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                325                 330                 335     


Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
            340                 345                 350         


Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
        355                 360                 365             


Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
    370                 375                 380                 


Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Ser Gln Ile 
385                 390                 395                 400 


Thr Lys Val 
            


<210>  13
<211>  591
<212>  PRT
<213>  Mus musculus

<400>  13

Met Arg Ala Gly Arg Gly Gly Val Pro Gly Ser Gly Gly Leu Arg Ala 
1               5                   10                  15      


Pro Pro Pro Pro Leu Leu Leu Leu Leu Leu Ala Met Leu Pro Ala Ala 
            20                  25                  30          


Ala Pro Arg Ser Pro Ala Leu Ala Ala Ala Pro Ala Gly Pro Ser Val 
        35                  40                  45              


Ser Leu Tyr Leu Ser Glu Asp Glu Val Arg Arg Leu Leu Gly Leu Asp 
    50                  55                  60                  


Ala Glu Leu Tyr Tyr Val Arg Asn Asp Leu Ile Ser His Tyr Ala Leu 
65                  70                  75                  80  


Ser Phe Asn Leu Leu Val Pro Ser Glu Thr Asn Phe Leu His Phe Thr 
                85                  90                  95      


Trp His Ala Lys Ser Lys Val Glu Tyr Lys Leu Gly Phe Gln Val Asp 
            100                 105                 110         


Asn Phe Val Ala Met Gly Met Pro Gln Val Asn Ile Ser Ala Gln Gly 
        115                 120                 125             


Glu Val Pro Arg Thr Leu Ser Val Phe Arg Val Glu Leu Ser Cys Thr 
    130                 135                 140                 


Gly Lys Val Asp Ser Glu Val Met Ile Leu Met Gln Leu Asn Leu Thr 
145                 150                 155                 160 


Val Asn Ser Ser Lys Asn Phe Thr Val Leu Asn Phe Lys Arg Arg Lys 
                165                 170                 175     


Met Cys Tyr Lys Lys Leu Glu Glu Val Lys Thr Ser Ala Leu Asp Lys 
            180                 185                 190         


Asn Thr Ser Arg Thr Ile Tyr Asp Pro Val His Ala Ala Pro Thr Thr 
        195                 200                 205             


Ser Thr Arg Val Phe Tyr Ile Ser Val Gly Val Cys Cys Ala Val Ile 
    210                 215                 220                 


Phe Leu Val Ala Ile Ile Leu Ala Val Leu His Leu His Ser Met Lys 
225                 230                 235                 240 


Arg Ile Glu Leu Asp Asp Ser Ile Ser Ala Ser Ser Ser Ser Gln Gly 
                245                 250                 255     


Leu Ser Gln Pro Ser Thr Gln Thr Thr Gln Tyr Leu Arg Ala Asp Thr 
            260                 265                 270         


Pro Asn Asn Ala Thr Pro Ile Thr Ser Tyr Pro Thr Leu Arg Ile Glu 
        275                 280                 285             


Lys Asn Asp Leu Arg Ser Val Thr Leu Leu Glu Ala Lys Ala Lys Val 
    290                 295                 300                 


Lys Asp Ile Ala Ile Ser Arg Glu Arg Ile Thr Leu Lys Asp Val Leu 
305                 310                 315                 320 


Gln Glu Gly Thr Phe Gly Arg Ile Phe His Gly Ile Leu Val Asp Glu 
                325                 330                 335     


Lys Asp Pro Asn Lys Glu Lys Gln Thr Phe Val Lys Thr Val Lys Asp 
            340                 345                 350         


Gln Ala Ser Glu Val Gln Val Thr Met Met Leu Thr Glu Ser Cys Lys 
        355                 360                 365             


Leu Arg Gly Leu His His Arg Asn Leu Leu Pro Ile Thr His Val Cys 
    370                 375                 380                 


Ile Glu Glu Gly Glu Lys Pro Met Val Val Leu Pro Tyr Met Asn Trp 
385                 390                 395                 400 


Gly Asn Leu Lys Leu Phe Leu Arg Gln Cys Lys Leu Val Glu Ala Asn 
                405                 410                 415     


Asn Pro Gln Ala Ile Ser Gln Gln Asp Leu Val His Met Ala Ile Gln 
            420                 425                 430         


Ile Ala Cys Gly Met Ser Tyr Leu Ala Arg Arg Glu Val Ile His Arg 
        435                 440                 445             


Asp Leu Ala Ala Arg Asn Cys Val Ile Asp Asp Thr Leu Gln Val Lys 
    450                 455                 460                 


Ile Thr Asp Asn Ala Leu Ser Arg Asp Leu Phe Pro Met Asp Tyr His 
465                 470                 475                 480 


Cys Leu Gly Asp Asn Glu Asn Arg Pro Val Arg Trp Met Ala Leu Glu 
                485                 490                 495     


Ser Leu Val Asn Asn Glu Phe Ser Ser Ala Ser Asp Val Trp Ala Phe 
            500                 505                 510         


Gly Val Thr Leu Trp Glu Leu Met Thr Leu Gly Gln Thr Pro Tyr Val 
        515                 520                 525             


Asp Ile Asp Pro Phe Glu Met Ala Ala Tyr Leu Lys Asp Gly Tyr Arg 
    530                 535                 540                 


Ile Ala Gln Pro Ile Asn Cys Pro Asp Glu Leu Phe Ala Val Met Ala 
545                 550                 555                 560 


Cys Cys Trp Ala Leu Asp Pro Glu Glu Arg Pro Lys Phe Gln Gln Leu 
                565                 570                 575     


Val Gln Cys Leu Thr Glu Phe His Ala Ala Leu Gly Ala Tyr Val 
            580                 585                 590     


<210>  14
<211>  2582
<212>  PRT
<213>  Mus musculus

<400>  14

Met Ala Asp Pro Ile Met Asp Leu Phe Asp Asp Pro Asn Leu Phe Gly 
1               5                   10                  15      


Leu Asp Ser Leu Thr Asp Asp Ser Phe Asn Gln Val Thr Gln Asp Pro 
            20                  25                  30          


Ile Glu Glu Ala Leu Gly Leu Pro Ser Ser Leu Asp Ser Leu Asp Gln 
        35                  40                  45              


Met Asn Gln Asp Gly Gly Gly Gly Asp Val Gly Asn Ser Ser Ala Ser 
    50                  55                  60                  


Asp Leu Val Pro Pro Pro Glu Glu Thr Ala Ser Thr Glu Leu Pro Lys 
65                  70                  75                  80  


Glu Ser Thr Ala Pro Ala Pro Glu Ser Leu Thr Leu His Asp Tyr Thr 
                85                  90                  95      


Thr Gln Pro Thr Ser Gln Glu Gln Pro Ala Gln Pro Val Leu Gln Thr 
            100                 105                 110         


Ser Thr Pro Thr Ala Gly Leu Leu Gln Val Ser Lys Ser Gln Glu Ile 
        115                 120                 125             


Leu Ser Gln Gly Asn Pro Phe Met Gly Val Ser Ala Thr Gly Val Ser 
    130                 135                 140                 


Pro Ser Asn Thr Gly Gly Gln Pro Ser Gln Ser Ala Pro Lys Ile Val 
145                 150                 155                 160 


Ile Leu Lys Ala Pro Pro Asn Ser Ser Val Thr Gly Thr His Val Ala 
                165                 170                 175     


Gln Ile Gln Ala Gln Gly Ile Thr Ser Thr Ala Gln Pro Leu Val Ala 
            180                 185                 190         


Gly Thr Ala Asn Gly Gly Lys Val Thr Phe Thr Lys Val Leu Thr Gly 
        195                 200                 205             


Thr Pro Leu Arg Pro Gly Val Ser Ile Val Ser Gly Asn Thr Val Leu 
    210                 215                 220                 


Ala Thr Lys Val Pro Gly Asn Gln Ala Ala Val Gln Arg Ile Val Gln 
225                 230                 235                 240 


Pro Ser Arg Pro Val Lys Gln Leu Val Leu Gln Pro Val Lys Gly Ser 
                245                 250                 255     


Ala Pro Ala Gly Asn Pro Gly Ala Ala Gly Pro Pro Leu Lys Pro Ala 
            260                 265                 270         


Val Thr Leu Thr Ser Thr Pro Thr Gln Gly Glu Ser Lys Arg Ile Thr 
        275                 280                 285             


Leu Val Leu Gln Gln Pro Gln Ser Gly Gly Pro Gln Gly His Arg His 
    290                 295                 300                 


Val Val Leu Gly Ser Leu Pro Gly Lys Ile Val Leu Gln Gly Asn Gln 
305                 310                 315                 320 


Leu Ala Ala Leu Thr Gln Ala Lys Asn Ala Gln Gly Gln Pro Ala Lys 
                325                 330                 335     


Val Val Thr Ile Gln Leu Gln Val Gln Gln Pro Gln Gln Lys Ile Gln 
            340                 345                 350         


Ile Val Pro Gln Pro Pro Ser Ser Gln Pro Gln Pro Gln Pro Gln Pro 
        355                 360                 365             


Pro Pro Ser Ala Gln Pro Leu Thr Leu Ser Ser Val Gln Gln Ala Gln 
    370                 375                 380                 


Ile Met Gly Pro Gly Gln Asn Pro Gly Gln Arg Leu Ser Val Pro Leu 
385                 390                 395                 400 


Lys Met Val Leu Gln Pro Gln Ala Gly Ser Ser Gln Gly Ala Ser Ser 
                405                 410                 415     


Gly Leu Ser Val Val Lys Val Leu Ser Ala Ser Glu Val Ala Ala Leu 
            420                 425                 430         


Ser Ser Pro Ala Ser Cys Ala Pro His Thr Ala Gly Lys Thr Gly Met 
        435                 440                 445             


Glu Glu Asn Arg Arg Leu Glu His Gln Lys Lys Gln Glu Lys Ala Asn 
    450                 455                 460                 


Arg Ile Val Ala Glu Ala Ile Ala Arg Ala Arg Ala Arg Gly Glu Gln 
465                 470                 475                 480 


Asn Ile Pro Arg Val Leu Asn Glu Asp Glu Leu Pro Ser Val Arg Pro 
                485                 490                 495     


Glu Glu Glu Gly Glu Lys Lys Arg Arg Lys Lys Ser Ser Gly Glu Arg 
            500                 505                 510         


Leu Lys Glu Glu Lys Pro Lys Lys Ser Lys Thr Ala Ala Ala Ser Lys 
        515                 520                 525             


Thr Lys Gly Lys Ser Lys Leu Asn Thr Ile Thr Pro Val Val Gly Lys 
    530                 535                 540                 


Lys Arg Lys Arg Asn Thr Ser Ser Asp Asn Ser Asp Val Glu Val Met 
545                 550                 555                 560 


Pro Ala Gln Ser Pro Arg Glu Asp Glu Glu Ser Ser Ile Gln Lys Arg 
                565                 570                 575     


Arg Ser Asn Arg Gln Val Lys Arg Lys Lys Tyr Thr Glu Asp Leu Asp 
            580                 585                 590         


Ile Lys Ile Thr Asp Asp Glu Glu Glu Glu Glu Val Asp Val Thr Gly 
        595                 600                 605             


Pro Ile Lys Pro Glu Pro Ile Leu Pro Glu Pro Val Gln Glu Pro Asp 
    610                 615                 620                 


Gly Glu Thr Leu Pro Ser Met Gln Phe Phe Val Glu Asn Pro Ser Glu 
625                 630                 635                 640 


Glu Asp Ala Ala Ile Val Asp Lys Val Leu Ser Met Arg Val Val Lys 
                645                 650                 655     


Lys Glu Leu Pro Ser Gly Gln Tyr Thr Glu Ala Glu Glu Phe Phe Val 
            660                 665                 670         


Lys Tyr Lys Asn Tyr Ser Tyr Leu His Cys Glu Trp Ala Thr Ile Ser 
        675                 680                 685             


Gln Leu Glu Lys Asp Lys Arg Ile His Gln Lys Leu Lys Arg Phe Lys 
    690                 695                 700                 


Thr Lys Met Ala Gln Met Arg His Phe Phe His Glu Asp Glu Glu Pro 
705                 710                 715                 720 


Phe Asn Pro Asp Tyr Val Glu Val Asp Arg Ile Leu Asp Glu Ser His 
                725                 730                 735     


Ser Val Asp Lys Asp Asn Gly Glu Pro Val Ile Tyr Tyr Leu Val Lys 
            740                 745                 750         


Trp Cys Ser Leu Pro Tyr Glu Asp Ser Thr Trp Glu Leu Lys Glu Asp 
        755                 760                 765             


Val Asp Glu Gly Lys Ile Arg Glu Phe Lys Arg Ile Gln Ser Arg His 
    770                 775                 780                 


Pro Glu Leu Arg Arg Val Asn Arg Pro Gln Ala Asn Ala Trp Lys Lys 
785                 790                 795                 800 


Leu Glu Leu Ser His Glu Tyr Lys Asn Arg Asn Gln Leu Arg Glu Tyr 
                805                 810                 815     


Gln Leu Glu Gly Val Asn Trp Leu Leu Phe Asn Trp Tyr Asn Arg Gln 
            820                 825                 830         


Asn Cys Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Ile Gln Ser 
        835                 840                 845             


Ile Ala Phe Leu Gln Glu Val Tyr Asn Val Gly Ile His Gly Pro Phe 
    850                 855                 860                 


Leu Val Ile Ala Pro Leu Ser Thr Ile Thr Asn Trp Glu Arg Glu Phe 
865                 870                 875                 880 


Asn Thr Trp Thr Glu Met Asn Thr Ile Val Tyr His Gly Ser Leu Ala 
                885                 890                 895     


Ser Arg Gln Met Ile Gln Gln Tyr Glu Met Tyr Cys Lys Asp Ser Arg 
            900                 905                 910         


Gly Arg Leu Ile Pro Gly Ala Tyr Lys Phe Asp Ala Leu Ile Thr Thr 
        915                 920                 925             


Phe Glu Met Ile Leu Ser Asp Cys Pro Glu Leu Arg Glu Ile Glu Trp 
    930                 935                 940                 


Arg Cys Val Ile Ile Asp Glu Ala His Arg Leu Lys Asn Arg Asn Cys 
945                 950                 955                 960 


Lys Leu Leu Asp Ser Leu Lys His Met Asp Leu Glu His Lys Val Leu 
                965                 970                 975     


Leu Thr Gly Thr Pro Leu Gln Asn Thr Val Glu Glu Leu Phe Ser Leu 
            980                 985                 990         


Leu His Phe Leu Glu Pro Ser Gln  Phe Pro Ser Glu Ser  Glu Phe Leu 
        995                 1000                 1005             


Lys Asp  Phe Gly Asp Leu Lys  Thr Glu Glu Gln Val  Gln Lys Leu 
    1010                 1015                 1020             


Gln Ala  Ile Leu Lys Pro Met  Met Leu Arg Arg Leu  Lys Glu Asp 
    1025                 1030                 1035             


Val Glu  Lys Asn Leu Ala Pro  Lys Gln Glu Thr Ile  Ile Glu Val 
    1040                 1045                 1050             


Glu Leu  Thr Asn Ile Gln Lys  Lys Tyr Tyr Arg Ala  Ile Leu Glu 
    1055                 1060                 1065             


Lys Asn  Phe Ser Phe Leu Ser  Lys Gly Ala Gly His  Thr Asn Met 
    1070                 1075                 1080             


Pro Asn  Leu Leu Asn Thr Met  Met Glu Leu Arg Lys  Cys Cys Asn 
    1085                 1090                 1095             


His Pro  Tyr Leu Ile Asn Gly  Ala Glu Glu Lys Ile  Leu Met Glu 
    1100                 1105                 1110             


Phe Arg  Glu Ala Cys His Ile  Ile Pro Gln Asp Phe  His Leu Gln 
    1115                 1120                 1125             


Ala Met  Val Arg Ser Ala Gly  Lys Leu Val Leu Ile  Asp Lys Leu 
    1130                 1135                 1140             


Leu Pro  Lys Leu Lys Ala Gly  Gly His Lys Val Leu  Ile Phe Ser 
    1145                 1150                 1155             


Gln Met  Val Arg Cys Leu Asp  Ile Leu Glu Asp Tyr  Leu Ile Gln 
    1160                 1165                 1170             


Arg Arg  Tyr Leu Tyr Glu Arg  Ile Asp Gly Arg Val  Arg Gly Asn 
    1175                 1180                 1185             


Leu Arg  Gln Ala Ala Ile Asp  Arg Phe Ser Lys Pro  Asp Ser Asp 
    1190                 1195                 1200             


Arg Phe  Val Phe Leu Leu Cys  Thr Arg Ala Gly Gly  Leu Gly Ile 
    1205                 1210                 1215             


Asn Leu  Thr Ala Ala Asp Thr  Cys Ile Ile Phe Asp  Ser Asp Trp 
    1220                 1225                 1230             


Asn Pro  Gln Asn Asp Leu Gln  Ala Gln Ala Arg Cys  His Arg Ile 
    1235                 1240                 1245             


Gly Gln  Ser Lys Ala Val Lys  Val Tyr Arg Leu Ile  Thr Arg Asn 
    1250                 1255                 1260             


Ser Tyr  Glu Arg Glu Met Phe  Asp Lys Ala Ser Leu  Lys Leu Gly 
    1265                 1270                 1275             


Leu Asp  Lys Ala Val Leu Gln  Ser Met Ser Gly Arg  Asp Gly Asn 
    1280                 1285                 1290             


Ile Thr  Gly Ile Gln Gln Phe  Ser Lys Lys Glu Ile  Glu Asp Leu 
    1295                 1300                 1305             


Leu Arg  Lys Gly Ala Tyr Ala  Ala Ile Met Glu Glu  Asp Asp Glu 
    1310                 1315                 1320             


Gly Ser  Lys Phe Cys Glu Glu  Asp Ile Asp Gln Ile  Leu Leu Arg 
    1325                 1330                 1335             


Arg Thr  Thr Thr Ile Thr Ile  Glu Ser Glu Gly Lys  Gly Ser Thr 
    1340                 1345                 1350             


Phe Ala  Lys Ala Ser Phe Val  Ala Ser Glu Asn Arg  Thr Asp Ile 
    1355                 1360                 1365             


Ser Leu  Asp Asp Pro Asn Phe  Trp Gln Lys Trp Ala  Lys Lys Ala 
    1370                 1375                 1380             


Asp Leu  Asp Met Asp Leu Leu  Asn Ser Lys Asn Asn  Leu Val Ile 
    1385                 1390                 1395             


Asp Thr  Pro Arg Val Arg Lys  Gln Thr Arg His Phe  Ser Thr Leu 
    1400                 1405                 1410             


Lys Asp  Asp Asp Leu Val Glu  Phe Ser Asp Leu Glu  Ser Glu Asp 
    1415                 1420                 1425             


Asp Glu  Arg Pro Arg Ser Arg  Arg His Asp Arg His  His Thr Tyr 
    1430                 1435                 1440             


Gly Arg  Thr Asp Cys Phe Arg  Val Glu Lys His Leu  Leu Val Tyr 
    1445                 1450                 1455             


Gly Trp  Gly Arg Trp Arg Asp  Ile Leu Ser His Gly  Arg Phe Lys 
    1460                 1465                 1470             


Arg Arg  Met Thr Glu Arg Asp  Val Glu Thr Ile Cys  Arg Ala Ile 
    1475                 1480                 1485             


Leu Val  Tyr Cys Leu Leu His  Tyr Arg Gly Asp Glu  Asn Ile Lys 
    1490                 1495                 1500             


Ser Phe  Ile Trp Asp Leu Ile  Ser Pro Ala Glu Asn  Gly Lys Thr 
    1505                 1510                 1515             


Lys Glu  Leu Gln Asn His Ser  Gly Leu Ser Ile Pro  Val Pro Arg 
    1520                 1525                 1530             


Gly Arg  Lys Gly Lys Lys Val  Lys Ser Gln Ser Thr  Phe Asp Ile 
    1535                 1540                 1545             


His Lys  Ala Asp Trp Ile Arg  Lys Tyr Asn Pro Asp  Thr Leu Phe 
    1550                 1555                 1560             


Gln Asp  Glu Ser Tyr Lys Lys  His Leu Lys His Gln  Cys Asn Lys 
    1565                 1570                 1575             


Val Leu  Leu Arg Val Arg Met  Leu Tyr Tyr Leu Arg  Gln Glu Val 
    1580                 1585                 1590             


Ile Gly  Asp Gln Ala Glu Lys  Val Leu Gly Gly Ala  Ile Ala Ser 
    1595                 1600                 1605             


Glu Ile  Asp Ile Trp Phe Pro  Val Val Asp Gln Leu  Glu Val Pro 
    1610                 1615                 1620             


Thr Thr  Trp Trp Asp Ser Glu  Ala Asp Lys Ser Leu  Leu Ile Gly 
    1625                 1630                 1635             


Val Phe  Lys His Gly Tyr Glu  Lys Tyr Asn Thr Met  Arg Ala Asp 
    1640                 1645                 1650             


Pro Ala  Leu Cys Phe Leu Glu  Lys Ala Gly Arg Pro  Asp Asp Lys 
    1655                 1660                 1665             


Ala Ile  Ala Ala Glu His Arg  Val Leu Asp Asn Phe  Ser Asp Leu 
    1670                 1675                 1680             


Val Glu  Gly Ile Asp Phe Asp  Lys Asp Cys Glu Asp  Pro Glu Tyr 
    1685                 1690                 1695             


Lys Pro  Leu Gln Gly Pro Pro  Lys Asp Pro Asp Asp  Glu Gly Asp 
    1700                 1705                 1710             


Pro Leu  Met Met Met Asp Glu  Glu Ile Ser Val Ile  Asp Gly Glu 
    1715                 1720                 1725             


Glu Ala  Gln Val Thr Gln Gln  Pro Gly His Leu Phe  Trp Pro Pro 
    1730                 1735                 1740             


Gly Ser  Ala Leu Thr Ala Arg  Leu Arg Arg Leu Val  Thr Ala Tyr 
    1745                 1750                 1755             


Gln Arg  Ser Tyr Lys Arg Glu  Gln Met Lys Met Glu  Ala Ala Glu 
    1760                 1765                 1770             


Arg Gly  Asp Arg Arg Arg Arg  Arg Cys Glu Ala Ala  Phe Lys Leu 
    1775                 1780                 1785             


Lys Glu  Ile Ala Arg Arg Glu  Lys Gln Gln Arg Trp  Thr Arg Arg 
    1790                 1795                 1800             


Glu Gln  Thr Asp Phe Tyr Arg  Val Val Ser Thr Phe  Gly Val Glu 
    1805                 1810                 1815             


Tyr Asp  Pro Asp Asn Met Gln  Phe His Trp Asp Arg  Phe Arg Thr 
    1820                 1825                 1830             


Phe Ala  Arg Leu Asp Lys Lys  Thr Asp Glu Ser Leu  Thr Lys Tyr 
    1835                 1840                 1845             


Phe His  Gly Phe Val Ala Met  Cys Arg Gln Val Cys  Arg Leu Pro 
    1850                 1855                 1860             


Pro Ala  Ala Gly Asp Glu Pro  Pro Asp Pro Asn Leu  Phe Ile Glu 
    1865                 1870                 1875             


Pro Ile  Thr Glu Glu Arg Ala  Ser Arg Thr Leu Tyr  Arg Ile Glu 
    1880                 1885                 1890             


Leu Leu  Arg Arg Leu Arg Glu  Gln Val Leu Cys His  Pro Leu Leu 
    1895                 1900                 1905             


Glu Asp  Arg Leu Ala Leu Cys  Gln Pro Pro Gly Leu  Glu Leu Pro 
    1910                 1915                 1920             


Lys Trp  Trp Glu Pro Val Arg  His Asp Gly Glu Leu  Leu Arg Gly 
    1925                 1930                 1935             


Ala Ala  Arg His Gly Val Ser  Gln Thr Asp Cys Asn  Ile Met Gln 
    1940                 1945                 1950             


Asp Pro  Asp Phe Ser Phe Leu  Ala Ala Arg Met Asn  Tyr Met Gln 
    1955                 1960                 1965             


Asn His  Gln Ala Gly Ala Ser  Ala Ala Ser Leu Ser  Arg Cys Ser 
    1970                 1975                 1980             


Thr Pro  Leu Leu His Gln Gln  Cys Thr Ser Arg Thr  Ala Ser Pro 
    1985                 1990                 1995             


Ser Pro  Leu Arg Pro Asp Ala  Pro Val Glu Lys Ser  Pro Glu Glu 
    2000                 2005                 2010             


Ser Thr  Val Gln Val Pro Asn  Leu Glu Ser Leu Thr  Leu Lys Leu 
    2015                 2020                 2025             


Glu Asp  Glu Val Val Ala Arg  Ser Arg Leu Thr Ser  Gln Asp Tyr 
    2030                 2035                 2040             


Glu Val  Arg Val Gly Ser Ser  Asp Thr Ala Pro Leu  Ser Arg Ser 
    2045                 2050                 2055             


Val Pro  Pro Val Lys Leu Glu  Asp Glu Asp Asp Ser  Asp Ser Glu 
    2060                 2065                 2070             


Leu Asp  Leu Ser Lys Leu Ser  Pro Ser Ser Ser Ser  Ser Ser Ser 
    2075                 2080                 2085             


Ser Ser  Ser Ser Ser Ser Ser  Thr Asp Glu Ser Glu  Asp Glu Lys 
    2090                 2095                 2100             


Glu Glu  Lys Leu Thr Ala Asp  Arg Ser Arg Pro Lys  Leu Tyr Asp 
    2105                 2110                 2115             


Glu Glu  Ser Leu Leu Ser Leu  Thr Met Ser Gln Asp  Gly Phe Pro 
    2120                 2125                 2130             


Asn Glu  Asp Gly Glu Gln Met  Thr Pro Glu Leu Leu  Leu Leu Gln 
    2135                 2140                 2145             


Glu Arg  Gln Arg Ala Ser Glu  Trp Pro Lys Asp Arg  Val Leu Ile 
    2150                 2155                 2160             


Asn Arg  Ile Asp Leu Val Cys  Gln Ala Val Leu Ser  Gly Lys Trp 
    2165                 2170                 2175             


Pro Ser  Asn Arg Arg Ser Gln  Glu Val Thr Ala Gly  Gly Ile Leu 
    2180                 2185                 2190             


Gly Pro  Gly Asn His Leu Leu  Asp Ser Pro Ser Leu  Thr Pro Gly 
    2195                 2200                 2205             


Glu Asp  Gly Asp Ser Pro Val  Pro Thr Pro Arg Ser  Gly Ser Ala 
    2210                 2215                 2220             


Ala Ser  Met Ala Glu Glu Glu  Ala Ser Ala Val Thr  Thr Ala Ala 
    2225                 2230                 2235             


Ala Gln  Phe Thr Lys Leu Arg  Arg Gly Met Asp Glu  Lys Glu Phe 
    2240                 2245                 2250             


Thr Val  Gln Ile Lys Asp Glu  Glu Gly Leu Lys Leu  Thr Phe Gln 
    2255                 2260                 2265             


Lys His  Arg Leu Met Ala Asn  Gly Val Met Gly Asp  Gly His Pro 
    2270                 2275                 2280             


Leu Phe  His Lys Lys Lys Gly  Asn Arg Lys Lys Leu  Val Glu Leu 
    2285                 2290                 2295             


Glu Val  Glu Cys Met Glu Glu  Pro Asn His Leu Asp  Leu Asp Leu 
    2300                 2305                 2310             


Glu Thr  Arg Ile Pro Val Ile  Asn Lys Val Asp Gly  Thr Leu Leu 
    2315                 2320                 2325             


Val Gly  Asp Glu Ala Pro Arg  Arg Ala Glu Leu Glu  Met Trp Leu 
    2330                 2335                 2340             


Gln Gly  His Pro Glu Phe Ala  Val Asp Pro Arg Phe  Leu Ala Tyr 
    2345                 2350                 2355             


Met Glu  Glu Arg Arg Lys Gln  Lys Trp Gln Arg Cys  Lys Lys Asn 
    2360                 2365                 2370             


Asn Lys  Ala Glu Leu Asn Cys  Leu Gly Met Glu Pro  Val Gln Pro 
    2375                 2380                 2385             


Ala Asn  Ser Arg Asn Gly Lys  Lys Gly His Tyr Ala  Glu Thr Ala 
    2390                 2395                 2400             


Phe Asn  Arg Val Leu Pro Gly  Pro Val Ala Pro Glu  Asn Ser Lys 
    2405                 2410                 2415             


Lys Arg  Val Arg Arg Thr Arg  Pro Asp Leu Ser Lys  Met Met Ala 
    2420                 2425                 2430             


Leu Met  Gln Gly Gly Ser Thr  Gly Ser Leu Ser Leu  His Asn Thr 
    2435                 2440                 2445             


Phe Gln  His Ser Ser Ser Asn  Leu Gln Ser Val Ser  Ser Leu Gly 
    2450                 2455                 2460             


His Ser  Ser Thr Thr Ser Ala  Ser Leu Pro Phe Met  Pro Phe Val 
    2465                 2470                 2475             


Met Gly  Ala Ala Ala Pro Pro  His Val Asp Ser Ser  Thr Met Leu 
    2480                 2485                 2490             


His His  His His His His Pro  His Pro His His His  His His His 
    2495                 2500                 2505             


His Pro  Gly Leu Arg Thr Thr  Gly Tyr Pro Ser Ser  Pro Ala Thr 
    2510                 2515                 2520             


Thr Thr  Ser Gly Thr Ala Leu  Arg Leu Pro Thr Leu  Gln Pro Glu 
    2525                 2530                 2535             


Asp Asp  Asp Glu Glu Glu Asp  Glu Glu Asp Asp Asp  Leu Ser Gln 
    2540                 2545                 2550             


Gly Tyr  Asp Ser Ser Glu Arg  Asp Phe Ser Leu Ile  Asp Asp Pro 
    2555                 2560                 2565             


Met Met  Pro Ala Asn Ser Asp  Ser Ser Glu Asp Ala  Asp Asp 
    2570                 2575                 2580         


<210>  15
<211>  1292
<212>  PRT
<213>  Mus musculus

<400>  15

Met Lys Leu Ala Thr Gly Leu Trp Val Trp Gly Ser Leu Leu Met Ala 
1               5                   10                  15      


Ala Gly Thr Val Gln Pro Ser Ala Ser Gln Ser Val Cys Ala Gly Thr 
            20                  25                  30          


Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala 
        35                  40                  45              


Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr 
                85                  90                  95      


Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu 
            100                 105                 110         


Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn 
        115                 120                 125             


Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn 
    130                 135                 140                 


Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr 
145                 150                 155                 160 


Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Met Thr 
                165                 170                 175     


Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser 
            180                 185                 190         


Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu 
        195                 200                 205             


Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro 
    210                 215                 220                 


Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly 
225                 230                 235                 240 


Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly 
                245                 250                 255     


Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr 
            260                 265                 270         


Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe 
        275                 280                 285             


Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys 
    290                 295                 300                 


Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile 
305                 310                 315                 320 


Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly 
                325                 330                 335     


Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn 
            340                 345                 350         


Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe 
        355                 360                 365             


Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Asp Ala Ile 
    370                 375                 380                 


Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly 
385                 390                 395                 400 


Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val 
                405                 410                 415     


Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu 
            420                 425                 430         


Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln 
        435                 440                 445             


Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser 
    450                 455                 460                 


Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr 
465                 470                 475                 480 


Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Arg Ala Glu Asn Cys 
                485                 490                 495     


Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Asn Asp Gly Cys 
            500                 505                 510         


Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg 
        515                 520                 525             


Gly Lys Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg 
    530                 535                 540                 


Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Ser Gln Cys Glu 
545                 550                 555                 560 


Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn 
                565                 570                 575     


Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys 
            580                 585                 590         


Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala 
        595                 600                 605             


Asp Gln Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly 
    610                 615                 620                 


Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly 
625                 630                 635                 640 


His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly 
                645                 650                 655     


Val Ile Gly Gly Leu Phe Ile Leu Val Ile Met Ala Leu Thr Phe Ala 
            660                 665                 670         


Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg 
        675                 680                 685             


Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala 
    690                 695                 700                 


Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg 
705                 710                 715                 720 


Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile 
                725                 730                 735     


Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile 
            740                 745                 750         


Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu 
        755                 760                 765             


Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu 
    770                 775                 780                 


Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro 
785                 790                 795                 800 


His Gly Cys Leu Leu Asp Tyr Val His Glu His Lys Asp Asn Ile Gly 
                805                 810                 815     


Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met 
            820                 825                 830         


Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn 
        835                 840                 845             


Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu 
    850                 855                 860                 


Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly 
865                 870                 875                 880 


Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys 
                885                 890                 895     


Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu 
            900                 905                 910         


Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu 
        915                 920                 925             


Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile 
    930                 935                 940                 


Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp 
945                 950                 955                 960 


Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg 
                965                 970                 975     


Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg 
            980                 985                 990         


Met Lys Leu Pro Ser Pro Asn Asp  Ser Lys Phe Phe Gln  Asn Leu Leu 
        995                 1000                 1005             


Asp Glu  Glu Asp Leu Glu Asp  Met Met Asp Ala Glu  Glu Tyr Leu 
    1010                 1015                 1020             


Val Pro  Gln Ala Phe Asn Ile  Pro Pro Pro Ile Tyr  Thr Ser Arg 
    1025                 1030                 1035             


Thr Arg  Ile Asp Ser Asn Arg  Asn Gln Phe Val Tyr  Gln Asp Gly 
    1040                 1045                 1050             


Gly Phe  Ala Thr Gln Gln Gly  Met Pro Met Pro Tyr  Arg Ala Thr 
    1055                 1060                 1065             


Thr Ser  Thr Ile Pro Glu Ala  Pro Val Ala Gln Gly  Ala Thr Ala 
    1070                 1075                 1080             


Glu Met  Phe Asp Asp Ser Cys  Cys Asn Gly Thr Leu  Arg Lys Pro 
    1085                 1090                 1095             


Val Ala  Pro His Val Gln Glu  Asp Ser Ser Thr Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Ala Asp  Pro Thr Val Phe Ala  Pro Glu Arg Asn Pro  Arg Gly Glu 
    1115                 1120                 1125             


Leu Asp  Glu Glu Gly Tyr Met  Thr Pro Met His Asp  Lys Pro Lys 
    1130                 1135                 1140             


Gln Glu  Tyr Leu Asn Pro Val  Glu Glu Asn Pro Phe  Val Ser Arg 
    1145                 1150                 1155             


Arg Lys  Asn Gly Asp Leu Gln  Ala Leu Asp Asn Pro  Glu Tyr His 
    1160                 1165                 1170             


Ser Ala  Ser Ser Gly Pro Pro  Lys Ala Glu Asp Glu  Tyr Val Asn 
    1175                 1180                 1185             


Glu Pro  Leu Tyr Leu Asn Thr  Phe Ala Asn Ala Leu  Gly Ser Ala 
    1190                 1195                 1200             


Glu Tyr  Met Lys Asn Ser Val  Leu Ser Val Pro Glu  Lys Ala Lys 
    1205                 1210                 1215             


Lys Ala  Phe Asp Asn Pro Asp  Tyr Trp Asn His Ser  Leu Pro Pro 
    1220                 1225                 1230             


Arg Ser  Thr Leu Gln His Pro  Asp Tyr Leu Gln Glu  Tyr Ser Thr 
    1235                 1240                 1245             


Lys Tyr  Phe Tyr Lys Gln Asn  Gly Arg Ile Arg Pro  Ile Val Ala 
    1250                 1255                 1260             


Glu Asn  Pro Glu Tyr Leu Ser  Glu Phe Ser Leu Lys  Pro Gly Thr 
    1265                 1270                 1275             


Met Leu  Pro Pro Pro Pro Tyr  Arg His Arg Asn Thr  Val Val 
    1280                 1285                 1290         


<210>  16
<211>  2009
<212>  PRT
<213>  Mus musculus

<400>  16

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Gly 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Val Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Met Asp Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Val Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Val Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Leu 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Ala Thr 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Asp Asp Glu Phe His Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Ile Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Glu His Phe Asn His Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Thr Asp Cys Lys 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Ile 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Val Lys  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Arg Lys Asp Asn  Cys Ile Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Cys  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Ala Glu Glu  Gln Pro Val Ile Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Ser  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Val Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Ile Phe  Glu Ile Ser Glu Val  Asn Asn His Ser Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Glu  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Asp Tyr Val Thr  Ser Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Leu Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Val  Lys Glu Asp Met Leu  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  17
<211>  655
<212>  PRT
<213>  Mus musculus

<400>  17

Met Arg Pro Ser Gly Thr Ala Arg Thr Thr Leu Leu Val Leu Leu Thr 
1               5                   10                  15      


Ala Leu Cys Ala Ala Gly Gly Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Arg Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Tyr Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Ala Leu 
            100                 105                 110         


Tyr Glu Asn Thr Tyr Ala Leu Ala Ile Leu Ser Asn Tyr Gly Thr Asn 
        115                 120                 125             


Arg Thr Gly Leu Arg Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


Ile Gly Ala Val Arg Phe Ser Asn Asn Pro Ile Leu Cys Asn Met Asp 
145                 150                 155                 160 


Thr Ile Gln Trp Arg Asp Ile Val Gln Asn Val Phe Met Ser Asn Met 
                165                 170                 175     


Ser Met Asp Leu Gln Ser His Pro Ser Ser Cys Pro Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Gly Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser His Arg Cys Arg 
    210                 215                 220                 


Gly Arg Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Gln Lys Phe Gln Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Pro Asp Tyr Tyr Glu Val Glu Glu 
305                 310                 315                 320 


Asp Gly Ile Arg Lys Cys Lys Lys Cys Asp Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Thr Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Tyr Cys Thr Ala Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Lys Gly Asp Ser Phe Thr Arg Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Arg Glu Leu Glu Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Asp Asn Trp Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Gly Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Arg Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Pro Asn Gln Lys Thr Lys Ile Met Asn Asn Arg Ala Glu 
                485                 490                 495     


Lys Asp Cys Lys Ala Val Asn His Val Cys Asn Pro Leu Cys Ser Ser 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Gln Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Glu Lys Cys Asn Ile Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Ile Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Asn Asn Val Cys His Leu Cys His Ala Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Ala Gly Pro Gly Leu Gln Gly Cys Glu Val Trp Pro 
625                 630                 635                 640 


Ser Gly Tyr Val Gln Trp Gln Trp Ile Leu Lys Thr Phe Trp Ile 
                645                 650                 655 


<210>  18
<211>  422
<212>  PRT
<213>  Mus musculus

<400>  18

Met Arg Asn Ile Phe Lys Arg Asn Gln Glu Pro Asn Val Ala Pro Ala 
1               5                   10                  15      


Thr Thr Thr Ala Thr Met Pro Leu Ala Pro Val Ala Pro Ala Asp Asn 
            20                  25                  30          


Ser Thr Glu Ser Thr Gly Pro Gly Glu Ser Gln Glu Asp Met Phe Ala 
        35                  40                  45              


Lys Leu Lys Glu Lys Phe Phe Asn Glu Ile Asn Lys Ile Pro Leu Pro 
    50                  55                  60                  


Pro Trp Ala Leu Ile Ala Met Ala Val Val Ala Gly Leu Leu Leu Leu 
65                  70                  75                  80  


Thr Cys Cys Phe Cys Ile Cys Lys Lys Cys Cys Cys Lys Lys Lys Lys 
                85                  90                  95      


Asn Lys Lys Glu Lys Gly Lys Gly Met Lys Asn Ala Met Asn Met Lys 
            100                 105                 110         


Asp Met Lys Gly Gly Gln Asp Asp Asp Asp Ala Glu Thr Gly Leu Thr 
        115                 120                 125             


Glu Gly Glu Gly Glu Gly Glu Glu Glu Lys Glu Pro Glu Asn Leu Gly 
    130                 135                 140                 


Lys Leu Gln Phe Ser Leu Asp Tyr Asp Phe Gln Ala Asn Gln Leu Thr 
145                 150                 155                 160 


Val Gly Val Leu Gln Ala Ala Glu Leu Pro Ala Leu Asp Met Gly Gly 
                165                 170                 175     


Thr Ser Asp Pro Tyr Val Lys Val Phe Leu Leu Pro Asp Lys Lys Lys 
            180                 185                 190         


Lys Tyr Glu Thr Lys Val His Arg Lys Thr Leu Asn Pro Ala Phe Asn 
        195                 200                 205             


Glu Thr Phe Thr Phe Lys Val Pro Tyr Gln Glu Leu Gly Gly Lys Thr 
    210                 215                 220                 


Leu Val Met Ala Ile Tyr Asp Phe Asp Arg Phe Ser Lys His Asp Ile 
225                 230                 235                 240 


Ile Gly Glu Val Lys Val Pro Met Asn Thr Val Asp Leu Gly Gln Pro 
                245                 250                 255     


Ile Glu Glu Trp Arg Asp Leu Gln Gly Gly Glu Lys Glu Glu Pro Glu 
            260                 265                 270         


Lys Leu Gly Asp Ile Cys Thr Ser Leu Arg Tyr Val Pro Thr Ala Gly 
        275                 280                 285             


Lys Leu Thr Val Cys Ile Leu Glu Ala Lys Asn Leu Lys Lys Met Asp 
    290                 295                 300                 


Val Gly Gly Leu Ser Asp Pro Tyr Val Lys Ile His Leu Met Gln Asn 
305                 310                 315                 320 


Gly Lys Arg Leu Lys Lys Lys Lys Thr Thr Val Lys Lys Lys Thr Leu 
                325                 330                 335     


Asn Pro Tyr Phe Asn Glu Ser Phe Ser Phe Glu Ile Pro Phe Glu Gln 
            340                 345                 350         


Ile Gln Lys Val Gln Val Val Val Thr Val Leu Asp Tyr Asp Lys Leu 
        355                 360                 365             


Gly Lys Asn Glu Ala Ile Gly Lys Ile Phe Val Gly Ser Asn Ala Thr 
    370                 375                 380                 


Gly Thr Glu Leu Arg His Trp Ser Asp Met Leu Ala Asn Pro Arg Arg 
385                 390                 395                 400 


Pro Ile Ala Gln Trp His Ser Leu Lys Pro Glu Glu Glu Val Asp Ala 
                405                 410                 415     


Leu Leu Gly Lys Asn Lys 
            420         


<210>  19
<211>  1544
<212>  PRT
<213>  Mus musculus

<400>  19

Met Glu Thr Ser Ala Pro Ala Pro Ala Leu Glu Lys Lys Glu Ala Lys 
1               5                   10                  15      


Ser Gly Leu Leu Glu Asp Ser Ser Phe Pro Asp Pro Gly Lys Lys Ala 
            20                  25                  30          


Cys Pro Leu Ala Val Ala Ala Ala Val Ala Ala His Gly Val Pro Gln 
        35                  40                  45              


Gln Leu Leu Pro Ala Phe His Ala Pro Leu Pro Ile Asp Met Arg His 
    50                  55                  60                  


Gln Glu Gly Arg Tyr His Tyr Asp Pro His Ser Val His Ser Val His 
65                  70                  75                  80  


Gly Pro Pro Thr Leu Ser Gly Ser Pro Val Ile Ser Asp Ile Ser Leu 
                85                  90                  95      


Ile Arg Leu Ser Pro His Pro Ala Gly Pro Gly Glu Ser Pro Phe Ser 
            100                 105                 110         


Ala His His Pro Tyr Val Asn Pro His Met Glu His Tyr Leu Arg Ser 
        115                 120                 125             


Val His Ser Ser Pro Thr Leu Ser Met Ile Ser Ala Ala Arg Gly Leu 
    130                 135                 140                 


Ser Pro Ala Asp Val Ala His Glu His Leu Lys Glu Arg Gly Leu Phe 
145                 150                 155                 160 


Ser Leu Ala Ala Pro Gly Thr Asn Pro Ser Asp Tyr Tyr His Gln Met 
                165                 170                 175     


Thr Leu Met Ala Ser His Pro Thr Pro Tyr Gly Asp Leu Leu Met Gln 
            180                 185                 190         


Ser Gly Gly Ala Ala Ser Ala Pro His Leu His Asp Tyr Leu Asn Pro 
        195                 200                 205             


Val Asp Ala Ser Arg Phe Ser Ser Pro Arg Val Thr Pro Arg Leu Ser 
    210                 215                 220                 


Arg Lys Arg Ala Leu Ser Ile Ser Pro Leu Ser Asp Ala Ser Leu Asp 
225                 230                 235                 240 


Leu Gln Arg Met Ile Arg Thr Ser Pro Asn Ser Leu Val Ala Tyr Ile 
                245                 250                 255     


Asn Asn Ser Arg Ser Ser Ser Ala Ala Ser Gly Ser Tyr Gly His Leu 
            260                 265                 270         


Ser Ala Gly Ala Leu Ser Pro Ala Phe Thr Phe Pro His Pro Ile Asn 
        275                 280                 285             


Pro Val Ala Tyr Gln Gln Ile Leu Ser Gln Gln Arg Gly Leu Gly Ser 
    290                 295                 300                 


Ala Phe Gly His Thr Pro Pro Leu Ile Gln Pro Ser Pro Thr Phe Leu 
305                 310                 315                 320 


Ala Gln Gln Pro Met Thr Leu Thr Ser Ile Ser Thr Met Pro Thr Gln 
                325                 330                 335     


Leu Ser Ser Ser Ser Ser Asn Cys Leu Asn Asp Ala Asn Gln Asn Lys 
            340                 345                 350         


Gln Asn Ser Glu Ser Ala Val Ser Ser Thr Val Asn Pro Ile Thr Ile 
        355                 360                 365             


His Lys Arg Ser Lys Val Lys Thr Glu Ala Glu Gly Leu Arg Pro Ala 
    370                 375                 380                 


Ser Pro Leu Gly Leu Thr Gln Glu Gln Leu Ala Asp Leu Lys Glu Asp 
385                 390                 395                 400 


Leu Asp Arg Asp Asp Cys Lys Gln Glu Ala Glu Val Val Ile Tyr Glu 
                405                 410                 415     


Thr Asn Cys His Trp Ala Asp Cys Thr Lys Glu Tyr Asp Thr Gln Glu 
            420                 425                 430         


Gln Leu Val His His Ile Asn Asn Glu His Ile His Gly Glu Lys Lys 
        435                 440                 445             


Glu Phe Val Cys Arg Trp Gln Ala Cys Thr Arg Glu Gln Lys Pro Phe 
    450                 455                 460                 


Lys Ala Gln Tyr Met Leu Val Val His Met Arg Arg His Thr Gly Glu 
465                 470                 475                 480 


Lys Pro His Lys Cys Thr Phe Glu Gly Cys Ser Lys Ala Tyr Ser Arg 
                485                 490                 495     


Leu Glu Asn Leu Lys Thr His Leu Arg Ser His Thr Gly Glu Lys Pro 
            500                 505                 510         


Tyr Val Cys Glu His Glu Gly Cys Asn Lys Ala Phe Ser Asn Ala Ser 
        515                 520                 525             


Asp Arg Ala Lys His Gln Asn Arg Thr His Ser Asn Glu Lys Pro Tyr 
    530                 535                 540                 


Ile Cys Lys Ile Pro Gly Cys Thr Lys Arg Tyr Thr Asp Pro Ser Ser 
545                 550                 555                 560 


Leu Arg Lys His Val Lys Thr Val His Gly Pro Asp Ala His Val Thr 
                565                 570                 575     


Lys Lys Gln Arg Asn Asp Val His Val Arg Ala Pro Leu Leu Lys Glu 
            580                 585                 590         


Asn Gly Asp Asn Glu Ala Ser Ala Glu Pro Gly Gly Arg Gly Pro Glu 
        595                 600                 605             


Glu Ser Val Glu Ala Ser Ser Thr Ser His Thr Val Glu Asp Cys Leu 
    610                 615                 620                 


His Ile Lys Ala Ile Lys Thr Glu Ser Ser Gly Leu Cys Gln Ser Ser 
625                 630                 635                 640 


Pro Gly Ala Gln Ser Ser Cys Ser Ser Glu Pro Ser Pro Leu Gly Ser 
                645                 650                 655     


Ala Pro Asn Asn Asp Ser Gly Met Glu Met Pro Gly Thr Gly Pro Gly 
            660                 665                 670         


Ser Leu Gly Asp Leu Thr Ala Leu Ala Asp Thr Cys Pro Gly Ala Asp 
        675                 680                 685             


Thr Ser Ala Leu Ala Ala Pro Ser Thr Gly Gly Leu Gln Leu Arg Lys 
    690                 695                 700                 


His Met Ser Thr Val His Arg Phe Glu Gln Leu Lys Arg Glu Lys Leu 
705                 710                 715                 720 


Lys Ser Leu Lys Asp Ser Cys Ser Trp Ala Gly Pro Ala Pro His Thr 
                725                 730                 735     


Arg Asn Thr Lys Leu Pro Pro Leu Pro Val Asn Gly Ser Val Leu Glu 
            740                 745                 750         


Asn Phe Asn Asn Thr Gly Gly Gly Gly Pro Ala Gly Leu Leu Pro Ser 
        755                 760                 765             


Gln Arg Leu Pro Glu Leu Thr Glu Val Thr Met Leu Ser Gln Leu Gln 
    770                 775                 780                 


Glu Arg Arg Asp Ser Ser Thr Ser Thr Met Ser Ser Ala Tyr Thr Val 
785                 790                 795                 800 


Ser Arg Arg Ser Ser Gly Ile Ser Pro Tyr Phe Ser Ser Arg Arg Ser 
                805                 810                 815     


Ser Glu Ala Ser Pro Leu Gly Gly Leu Arg Pro His Asn Ala Ser Ser 
            820                 825                 830         


Ala Asp Ser Tyr Asp Pro Ile Ser Thr Asp Ala Ser Arg Arg Ser Ser 
        835                 840                 845             


Glu Ala Ser Gln Cys Ser Gly Gly Gly Pro Gly Leu Leu Asn Leu Thr 
    850                 855                 860                 


Pro Ala Gln Gln Tyr Asn Leu Arg Ala Lys Tyr Ala Ala Ala Thr Gly 
865                 870                 875                 880 


Gly Pro Pro Pro Thr Pro Leu Pro Gly Leu Asp Arg Val Ser Leu Arg 
                885                 890                 895     


Thr Arg Leu Ala Leu Leu Asp Ala Pro Glu Arg Ala Leu Pro Gly Ala 
            900                 905                 910         


Cys Pro His Pro Leu Gly Pro Arg Arg Gly Ser Asp Gly Pro Thr Tyr 
        915                 920                 925             


Ser His Gly His Gly His Gly Tyr Ala Gly Ala Ala Pro Ala Phe Pro 
    930                 935                 940                 


His Glu Gly Pro Asn Ser Ser Thr Arg Arg Ala Ser Asp Pro Val Arg 
945                 950                 955                 960 


Arg Pro Asp Pro Leu Ile Leu Pro Arg Val Gln Arg Phe His Ser Thr 
                965                 970                 975     


His Asn Met Asn Pro Gly Ser Leu Pro Pro Cys Ala Asp Arg Arg Gly 
            980                 985                 990         


Leu His Val Gln Ser His Pro Ser  Val Asp Ser Asn Leu  Thr Arg Asn 
        995                 1000                 1005             


Ala Tyr  Ser Pro Arg Pro Pro  Ser Ile Asn Glu Asn  Val Val Met 
    1010                 1015                 1020             


Glu Ala  Val Ala Ala Gly Val  Asp Gly Pro Gly Leu  Glu Cys Asp 
    1025                 1030                 1035             


Leu Gly  Leu Val Glu Asp Glu  Leu Val Leu Pro Asp  Asp Val Val 
    1040                 1045                 1050             


Gln Tyr  Ile Lys Ala His Thr  Gly Gly Thr Leu Asp  Asp Gly Ile 
    1055                 1060                 1065             


Arg Gln  Gly Tyr Pro Thr Glu  Gly Thr Gly Phe Pro  Glu Asn Ser 
    1070                 1075                 1080             


Lys Leu  Pro Ser Pro Gly Leu  Gln Gly His Arg Arg  Leu Ala Ala 
    1085                 1090                 1095             


Ala Asp  Ser Asn Met Gly Pro  Ser Ala Pro Gly Leu  Gly Gly Cys 
    1100                 1105                 1110             


Gln Leu  Ser Tyr Ser Pro Ser  Ser Asn Leu Asn Lys  Ser Asn Met 
    1115                 1120                 1125             


Pro Val  Gln Trp Asn Glu Val  Ser Ser Gly Thr Val  Asp Ala Leu 
    1130                 1135                 1140             


Pro Thr  Gln Val Lys Pro Pro  Pro Phe Pro His Ser  Asn Leu Ala 
    1145                 1150                 1155             


Val Val  Gln Gln Lys Pro Ala  Phe Gly Gln Tyr Pro  Gly Tyr Asn 
    1160                 1165                 1170             


Pro Gln  Ser Val Gln Ser Ser  Ser Gly Gly Leu Asp  Ser Thr Gln 
    1175                 1180                 1185             


Pro His  Leu Gln Leu Arg Gly  Ala Pro Ser Ala Ser  Arg Gly Ser 
    1190                 1195                 1200             


Tyr Thr  Gln Gln Pro Arg Gln  Pro Ala Ala Gly Ser  Gln Cys Leu 
    1205                 1210                 1215             


Gly Met  Ser Ala Ala Met Ser  Pro Gln Ala Ser Tyr  Ser Gln Ala 
    1220                 1225                 1230             


His Pro  Gln Leu Ser Pro Asn  Ile Val Ser Gly Ser  Leu Asn Gln 
    1235                 1240                 1245             


Phe Ser  Pro Ser Cys Ser Asn  Met Ala Ala Lys Pro  Ser His Leu 
    1250                 1255                 1260             


Gly Leu  Pro Gln Gln Met Glu  Val Val Pro Asn Ala  Thr Ile Met 
    1265                 1270                 1275             


Asn Gly  His Gln Arg Glu His  Gly Val Pro Asn Ser  Ser Leu Ala 
    1280                 1285                 1290             


Ala Val  Ser Gln Pro His Pro  Val Leu Ser Tyr Pro  Gln Gln Asp 
    1295                 1300                 1305             


Ser Tyr  Gln Gln Gly Ser Asn  Leu Leu Ser Ser His  Gln Pro Gly 
    1310                 1315                 1320             


Phe Met  Glu Ser Gln Gln Asn  Ala Gly Phe Gly Leu  Met Gln Pro 
    1325                 1330                 1335             


Arg Pro  Pro Leu Glu Pro Asn  Thr Ala Ser Arg His  Arg Gly Val 
    1340                 1345                 1350             


Arg Ser  Gly Gln Gln Gln Leu  Tyr Ala Arg Thr Thr  Gly Gln Ala 
    1355                 1360                 1365             


Met Val  Thr Ser Ala Asn Gln  Glu Thr Ala Glu Ala  Met Pro Lys 
    1370                 1375                 1380             


Gly Pro  Ala Gly Thr Met Val  Ser Leu Ala Pro Gln  Pro Ser Gln 
    1385                 1390                 1395             


Asp Thr  Gly Arg Ala Gln Asp  Gln Asn Thr Leu Tyr  Tyr Tyr Gly 
    1400                 1405                 1410             


Gln Ile  His Met Tyr Glu Gln  Asn Gly Gly Cys Pro  Ala Val Gln 
    1415                 1420                 1425             


Pro Gln  Pro Pro Gln Pro Gln  Ala Cys Ser Asp Ser  Ile Gln Pro 
    1430                 1435                 1440             


Glu Pro  Leu Pro Ser Pro Gly  Val Asn Gln Val Ser  Ser Thr Val 
    1445                 1450                 1455             


Asp Ser  Gln Leu Leu Glu Pro  Pro Gln Ile Asp Phe  Asp Ala Ile 
    1460                 1465                 1470             


Met Asp  Asp Gly Asp His Ser  Ser Leu Phe Ser Gly  Ala Leu Ser 
    1475                 1480                 1485             


Pro Thr  Leu Leu His Asn Leu  Ser Gln Asn Ser Ser  Arg Leu Thr 
    1490                 1495                 1500             


Thr Pro  Arg Asn Ser Leu Thr  Leu Pro Ser Ile Pro  Ala Gly Ile 
    1505                 1510                 1515             


Ser Asn  Met Ala Val Gly Asp  Met Ser Ser Met Leu  Thr Ser Leu 
    1520                 1525                 1530             


Ala Glu  Glu Ser Lys Phe Leu  Asn Met Met Thr 
    1535                 1540                 


<210>  20
<211>  365
<212>  PRT
<213>  Mus musculus

<400>  20

Met Pro Ser Ile Ser Ser Asp Arg Ala Ala Leu Cys Ala Gly Cys Gly 
1               5                   10                  15      


Gly Lys Ile Ser Asp Arg Tyr Tyr Leu Leu Ala Val Asp Lys Gln Trp 
            20                  25                  30          


His Met Arg Cys Leu Lys Cys Cys Glu Cys Lys Leu Asn Leu Glu Ser 
        35                  40                  45              


Glu Leu Thr Cys Phe Ser Lys Asp Gly Ser Ile Tyr Cys Lys Glu Asp 
    50                  55                  60                  


Tyr Tyr Arg Arg Phe Ser Val Gln Arg Cys Ala Arg Cys His Leu Gly 
65                  70                  75                  80  


Ile Ser Ala Ser Glu Met Val Met Arg Ala Arg Asp Leu Val Tyr His 
                85                  90                  95      


Leu Asn Cys Phe Thr Cys Thr Thr Cys Asn Lys Met Leu Thr Thr Gly 
            100                 105                 110         


Asp His Phe Gly Met Lys Asp Ser Leu Val Tyr Cys Arg Leu His Phe 
        115                 120                 125             


Glu Ala Leu Leu Gln Gly Glu Tyr Pro Ala His Phe Asn His Ala Asp 
    130                 135                 140                 


Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ser Ala Gly Leu 
145                 150                 155                 160 


Gly Ser Ala Gly Ala Asn Pro Leu Gly Leu Pro Tyr Tyr Asn Gly Val 
                165                 170                 175     


Gly Thr Val Gln Lys Gly Arg Pro Arg Lys Arg Lys Ser Pro Gly Pro 
            180                 185                 190         


Gly Ala Asp Leu Ala Ala Tyr Asn Ala Ala Leu Ser Cys Asn Glu Asn 
        195                 200                 205             


Asp Ala Glu His Leu Asp Arg Asp Gln Pro Tyr Pro Ser Ser Gln Lys 
    210                 215                 220                 


Thr Lys Arg Met Arg Thr Ser Phe Lys His His Gln Leu Arg Thr Met 
225                 230                 235                 240 


Lys Ser Tyr Phe Ala Ile Asn His Asn Pro Asp Ala Lys Asp Leu Lys 
                245                 250                 255     


Gln Leu Ala Gln Lys Thr Gly Leu Thr Lys Arg Val Leu Gln Val Trp 
            260                 265                 270         


Phe Gln Asn Ala Arg Ala Lys Phe Arg Arg Asn Leu Leu Arg Gln Glu 
        275                 280                 285             


Asn Thr Gly Val Asp Lys Thr Ser Asp Ala Thr Leu Gln Thr Gly Thr 
    290                 295                 300                 


Pro Ser Gly Pro Ala Ser Glu Leu Ser Asn Ala Ser Leu Ser Pro Ser 
305                 310                 315                 320 


Ser Thr Pro Thr Thr Leu Thr Asp Leu Thr Ser Pro Thr Leu Pro Thr 
                325                 330                 335     


Val Thr Ser Val Leu Thr Ser Val Pro Gly Asn Leu Glu Gly His Glu 
            340                 345                 350         


Pro His Ser Pro Ser Gln Thr Thr Leu Thr Asn Leu Phe 
        355                 360                 365 


