                         SEQUENCE LISTING

<110>  ModernaTX, Inc.
 
<120>  STABILIZED CORONAVIRUS SPIKE PROTEIN VACCINES

<130>  M1378.70170WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 63/210,436
<151>  2021-06-14

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  3995
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
gggaaauaag agagaaaaga agaguaagaa gaaauauaag accccggcgc cgccaccaug       60

uucguguucc uggugcugcu gccccuggug agcagccagu gcgugaaccu gaccacccgg      120

acccagcugc caccagccua caccaacagc uucacccggg gcgucuacua ccccgacaag      180

guguuccgga gcagcguccu gcacagcacc caggaccugu uccugcccuu cuucagcaac      240

gugaccuggu uccacgccau ccacgugagc ggcaccaacg gcaccaagcg guucgacaac      300

cccgugcugc ccuucaacga cggcguguac uucgccagca ccgagaagag caacaucauc      360

cggggcugga ucuucggcac cacccuggac agcaagaccc agagccugcu gaucgugaau      420

aacgccacca acguggugau caaggugugc gaguuccagu ucugcaacga ccccuuccug      480

ggcguguacu accacaagaa caacaagagc uggauggaga gcgaguuccg gguguacagc      540

agcgccaaca acugcaccuu cgaguacgug agccagcccu uccugaugga ccuggagggc      600

aagcagggca acuucaagaa ccugcgggag uucguguuca agaacaucga cggcuacuuc      660

aagaucuaca gcaagcacac cccaaucaac cuggugcggg aucugcccca gggcuucuca      720

gcccuggagc cccuggugga ccugcccauc ggcaucaaca ucacccgguu ccagacccug      780

cuggcccugc accggagcua ccugacccca ggcgacagca gcagcgggug gacagcaggc      840

gcggcugcuu acuacguggg cuaccugcag ccccggaccu uccugcugaa guacaacgag      900

aacggcacca ucaccgacgc cguggacugc gcccuggacc cucugagcga gaccaagugc      960

acccugaaga gcuucaccgu ggagaagggc aucuaccaga ccagcaacuu ccgggugcag     1020

cccaccgaga gcaucgugcg guuccccaac aucaccaacc ugugccccuu cggcgaggug     1080

uucaacgcca cccgguucgc cagcguguac gccuggaacc ggaagcggau cagcaacugc     1140

guggccgacu acagcgugcu guacaacagc gccagcuuca gcaccuucaa gugcuacggc     1200

gugagcccca ccaagcugaa cgaccugugc uucaccaacg uguacgccga cagcuucgug     1260

auccguggcg acgaggugcg gcagaucgca cccggccaga caggcaagau cgccgacuac     1320

aacuacaagc ugcccgacga cuucaccggc ugcgugaucg ccuggaacag caacaaccuc     1380

gacagcaagg ugggcggcaa cuacaacuac cuguaccggc uguuccggaa gagcaaccug     1440

aagcccuucg agcgggacau cagcaccgag aucuaccaag ccggcuccac cccuugcaac     1500

ggcguggagg gcuucaacug cuacuucccu cugcagagcu acggcuucca gcccaccaac     1560

ggcgugggcu accagcccua ccggguggug gugcugagcu ucgagcugcu gcacgcccca     1620

gccaccgugu guggccccaa gaagagcacc aaccugguga agaacaagug cgugaacuuc     1680

aacuucaacg gccuuaccgg caccggcgug cugaccgaga gcaacaagaa auuccugccc     1740

uuucagcagu ucggccggga caucgccgac accaccgacg cugugcggga uccccagacc     1800

cuggagaucc uggacaucac cccuugcagc uucggcggcg ugagcgugau caccccaggc     1860

accaacacca gcaaccaggu ggccgugcug uaccaggacg ugaacugcac cgaggugccc     1920

guggccaucc acgccgacca gcugacaccc accuggcggg ucuacagcac cggcagcaac     1980

guguuccaga cccgggccgg uugccugauc ggcgccgagc acgugaacaa cagcuacgag     2040

ugcgacaucc ccaucggcgc cggcaucugu gccagcuacc agacccagac caauucaccc     2100

cggagggcaa ggagcguggc cagccagagc aucaucgccu acaccaugag ccugggcgcc     2160

gagaacagcg uggccuacag caacaacagc aucgccaucc ccaccaacuu caccaucagc     2220

gugaccaccg agauucugcc cgugagcaug accaagacca gcguggacug caccauguac     2280

aucugcggcg acagcaccga gugcagcaac cugcugcugc aguacggcag cuucugcacc     2340

cagcugaacc gggcccugac cggcaucgcc guggagcagg acaagaacac ccaggaggug     2400

uucgcccagg ugaagcagau cuacaagacc ccucccauca aggacuucgg cggcuucaac     2460

uucagccaga uccugcccga ccccagcaag cccagcaagc ggagcuucau cgaggaccug     2520

cuguucaaca aggugacccu agccgacgcc ggcuucauca agcaguacgg cgacugccuc     2580

ggcgacauag ccgcccggga ccugaucugc gcccagaagu ucaacggccu gaccgugcug     2640

ccuccccugc ugaccgacga gaugaucgcc caguacacca gcgcccuguu agccggaacc     2700

aucaccagcg gcuggacuuu cggcgcugga gccgcucugc agauccccuu cgccaugcag     2760

auggccuacc gguucaacgg caucggcgug acccagaacg ugcuguacga gaaccagaag     2820

cugaucgcca accaguucaa cagcgccauc ggcaagaucc aggacagccu gagcagcacc     2880

gcuagcgccc ugggcaagcu gcaggacgug gugaaccaga acgcccaggc ccugaacacc     2940

cuggugaagc agcugagcag caacuucggc gccaucagca gcgugcugaa cgacauccug     3000

agccggcugg acccucccga ggccgaggug cagaucgacc ggcugaucac uggccggcug     3060

cagagccugc agaccuacgu gacccagcag cugauccggg ccgccgagau ucgggccagc     3120

gccaaccugg ccgccaccaa gaugagcgag ugcgugcugg gccagagcaa gcggguggac     3180

uucugcggca agggcuacca ccugaugagc uuuccccaga gcgcacccca cggaguggug     3240

uuccugcacg ugaccuacgu gcccgcccag gagaagaacu ucaccaccgc cccagccauc     3300

ugccacgacg gcaaggccca cuuuccccgg gagggcgugu ucgugagcaa cggcacccac     3360

ugguucguga cccagcggaa cuucuacgag ccccagauca ucaccaccga caacaccuuc     3420

gugagcggca acugcgacgu ggugaucggc aucgugaaca acaccgugua cgauccccug     3480

cagcccgagc uggacagcuu caaggaggag cuggacaagu acuucaagaa ucacaccagc     3540

cccgacgugg accugggcga caucagcggc aucaacgcca gcguggugaa cauccagaag     3600

gagaucgauc ggcugaacga gguggccaag aaccugaacg agagccugau cgaccugcag     3660

gagcugggca aguacgagca guacaucaag uggcccuggu acaucuggcu gggcuucauc     3720

gccggccuga ucgccaucgu gauggugacc aucaugcugu gcugcaugac cagcugcugc     3780

agcugccuga agggcuguug cagcugcggc agcugcugca aguucgacga ggacgacagc     3840

gagcccgugc ugaagggcgu gaagcugcac uacaccugau aauaggcugg agccucggug     3900

gccuagcuuc uugccccuug ggccuccccc cagccccucc uccccuuccu gcacccguac     3960

ccccgugguc uuugaauaaa gucugagugg gcggc                                3995


<210>  2
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
gggaaauaag agagaaaaga agaguaagaa gaaauauaag accccggcgc cgccacc          57


<210>  3
<211>  3819
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
auguucgugu uccuggugcu gcugccccug gugagcagcc agugcgugaa ccugaccacc       60

cggacccagc ugccaccagc cuacaccaac agcuucaccc ggggcgucua cuaccccgac      120

aagguguucc ggagcagcgu ccugcacagc acccaggacc uguuccugcc cuucuucagc      180

aacgugaccu gguuccacgc cauccacgug agcggcacca acggcaccaa gcgguucgac      240

aaccccgugc ugcccuucaa cgacggcgug uacuucgcca gcaccgagaa gagcaacauc      300

auccggggcu ggaucuucgg caccacccug gacagcaaga cccagagccu gcugaucgug      360

aauaacgcca ccaacguggu gaucaaggug ugcgaguucc aguucugcaa cgaccccuuc      420

cugggcgugu acuaccacaa gaacaacaag agcuggaugg agagcgaguu ccggguguac      480

agcagcgcca acaacugcac cuucgaguac gugagccagc ccuuccugau ggaccuggag      540

ggcaagcagg gcaacuucaa gaaccugcgg gaguucgugu ucaagaacau cgacggcuac      600

uucaagaucu acagcaagca caccccaauc aaccuggugc gggaucugcc ccagggcuuc      660

ucagcccugg agccccuggu ggaccugccc aucggcauca acaucacccg guuccagacc      720

cugcuggccc ugcaccggag cuaccugacc ccaggcgaca gcagcagcgg guggacagca      780

ggcgcggcug cuuacuacgu gggcuaccug cagccccgga ccuuccugcu gaaguacaac      840

gagaacggca ccaucaccga cgccguggac ugcgcccugg acccucugag cgagaccaag      900

ugcacccuga agagcuucac cguggagaag ggcaucuacc agaccagcaa cuuccgggug      960

cagcccaccg agagcaucgu gcgguucccc aacaucacca accugugccc cuucggcgag     1020

guguucaacg ccacccgguu cgccagcgug uacgccugga accggaagcg gaucagcaac     1080

ugcguggccg acuacagcgu gcuguacaac agcgccagcu ucagcaccuu caagugcuac     1140

ggcgugagcc ccaccaagcu gaacgaccug ugcuucacca acguguacgc cgacagcuuc     1200

gugauccgug gcgacgaggu gcggcagauc gcacccggcc agacaggcaa gaucgccgac     1260

uacaacuaca agcugcccga cgacuucacc ggcugcguga ucgccuggaa cagcaacaac     1320

cucgacagca aggugggcgg caacuacaac uaccuguacc ggcuguuccg gaagagcaac     1380

cugaagcccu ucgagcggga caucagcacc gagaucuacc aagccggcuc caccccuugc     1440

aacggcgugg agggcuucaa cugcuacuuc ccucugcaga gcuacggcuu ccagcccacc     1500

aacggcgugg gcuaccagcc cuaccgggug guggugcuga gcuucgagcu gcugcacgcc     1560

ccagccaccg uguguggccc caagaagagc accaaccugg ugaagaacaa gugcgugaac     1620

uucaacuuca acggccuuac cggcaccggc gugcugaccg agagcaacaa gaaauuccug     1680

cccuuucagc aguucggccg ggacaucgcc gacaccaccg acgcugugcg ggauccccag     1740

acccuggaga uccuggacau caccccuugc agcuucggcg gcgugagcgu gaucacccca     1800

ggcaccaaca ccagcaacca gguggccgug cuguaccagg acgugaacug caccgaggug     1860

cccguggcca uccacgccga ccagcugaca cccaccuggc gggucuacag caccggcagc     1920

aacguguucc agacccgggc cgguugccug aucggcgccg agcacgugaa caacagcuac     1980

gagugcgaca uccccaucgg cgccggcauc ugugccagcu accagaccca gaccaauuca     2040

ccccggaggg caaggagcgu ggccagccag agcaucaucg ccuacaccau gagccugggc     2100

gccgagaaca gcguggccua cagcaacaac agcaucgcca uccccaccaa cuucaccauc     2160

agcgugacca ccgagauucu gcccgugagc augaccaaga ccagcgugga cugcaccaug     2220

uacaucugcg gcgacagcac cgagugcagc aaccugcugc ugcaguacgg cagcuucugc     2280

acccagcuga accgggcccu gaccggcauc gccguggagc aggacaagaa cacccaggag     2340

guguucgccc aggugaagca gaucuacaag accccuccca ucaaggacuu cggcggcuuc     2400

aacuucagcc agauccugcc cgaccccagc aagcccagca agcggagcuu caucgaggac     2460

cugcuguuca acaaggugac ccuagccgac gccggcuuca ucaagcagua cggcgacugc     2520

cucggcgaca uagccgcccg ggaccugauc ugcgcccaga aguucaacgg ccugaccgug     2580

cugccucccc ugcugaccga cgagaugauc gcccaguaca ccagcgcccu guuagccgga     2640

accaucacca gcggcuggac uuucggcgcu ggagccgcuc ugcagauccc cuucgccaug     2700

cagauggccu accgguucaa cggcaucggc gugacccaga acgugcugua cgagaaccag     2760

aagcugaucg ccaaccaguu caacagcgcc aucggcaaga uccaggacag ccugagcagc     2820

accgcuagcg cccugggcaa gcugcaggac guggugaacc agaacgccca ggcccugaac     2880

acccugguga agcagcugag cagcaacuuc ggcgccauca gcagcgugcu gaacgacauc     2940

cugagccggc uggacccucc cgaggccgag gugcagaucg accggcugau cacuggccgg     3000

cugcagagcc ugcagaccua cgugacccag cagcugaucc gggccgccga gauucgggcc     3060

agcgccaacc uggccgccac caagaugagc gagugcgugc ugggccagag caagcgggug     3120

gacuucugcg gcaagggcua ccaccugaug agcuuucccc agagcgcacc ccacggagug     3180

guguuccugc acgugaccua cgugcccgcc caggagaaga acuucaccac cgccccagcc     3240

aucugccacg acggcaaggc ccacuuuccc cgggagggcg uguucgugag caacggcacc     3300

cacugguucg ugacccagcg gaacuucuac gagccccaga ucaucaccac cgacaacacc     3360

uucgugagcg gcaacugcga cguggugauc ggcaucguga acaacaccgu guacgauccc     3420

cugcagcccg agcuggacag cuucaaggag gagcuggaca aguacuucaa gaaucacacc     3480

agccccgacg uggaccuggg cgacaucagc ggcaucaacg ccagcguggu gaacauccag     3540

aaggagaucg aucggcugaa cgagguggcc aagaaccuga acgagagccu gaucgaccug     3600

caggagcugg gcaaguacga gcaguacauc aaguggcccu gguacaucug gcugggcuuc     3660

aucgccggcc ugaucgccau cgugauggug accaucaugc ugugcugcau gaccagcugc     3720

ugcagcugcc ugaagggcug uugcagcugc ggcagcugcu gcaaguucga cgaggacgac     3780

agcgagcccg ugcugaaggg cgugaagcug cacuacacc                            3819


<210>  4
<211>  119
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
ugauaauagg cuggagccuc gguggccuag cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccgu ggucuuugaa uaaagucuga gugggcggc       119


<210>  5
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  6
<211>  3956
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
gggaaauaag agagaaaaga agaguaagaa gaaauauaag accccggcgc cgccaccaug       60

uucguguucc uggugcugcu gccccuggug agcagccagu gcgugaaccu gaccacccgg      120

acccagcugc caccagccua caccaacagc uucacccggg gcgucuacua ccccgacaag      180

guguuccgga gcagcguccu gcacagcacc caggaccugu uccugcccuu cuucagcaac      240

gugaccuggu uccacgccau ccacgugagc ggcaccaacg gcaccaagcg guucgacaac      300

cccgugcugc ccuucaacga cggcguguac uucgccagca ccgagaagag caacaucauc      360

cggggcugga ucuucggcac cacccuggac agcaagaccc agagccugcu gaucgugaau      420

aacgccacca acguggugau caaggugugc gaguuccagu ucugcaacga ccccuuccug      480

ggcguguacu accacaagaa caacaagagc uggauggaga gcgaguuccg gguguacagc      540

agcgccaaca acugcaccuu cgaguacgug agccagcccu uccugaugga ccuggagggc      600

aagcagggca acuucaagaa ccugcgggag uucguguuca agaacaucga cggcuacuuc      660

aagaucuaca gcaagcacac cccaaucaac cuggugcggg aucugcccca gggcuucuca      720

gcccuggagc cccuggugga ccugcccauc ggcaucaaca ucacccgguu ccagacccug      780

cuggcccugc accggagcua ccugacccca ggcgacagca gcagcgggug gacagcaggc      840

gcggcugcuu acuacguggg cuaccugcag ccccggaccu uccugcugaa guacaacgag      900

aacggcacca ucaccgacgc cguggacugc gcccuggacc cucugagcga gaccaagugc      960

acccugaaga gcuucaccgu ggagaagggc aucuaccaga ccagcaacuu ccgggugcag     1020

cccaccgaga gcaucgugcg guuccccaac aucaccaacc ugugccccuu cggcgaggug     1080

uucaacgcca cccgguucgc cagcguguac gccuggaacc ggaagcggau cagcaacugc     1140

guggccgacu acagcgugcu guacaacagc gccagcuuca gcaccuucaa gugcuacggc     1200

gugagcccca ccaagcugaa cgaccugugc uucaccaacg uguacgccga cagcuucgug     1260

auccguggcg acgaggugcg gcagaucgca cccggccaga caggcaagau cgccgacuac     1320

aacuacaagc ugcccgacga cuucaccggc ugcgugaucg ccuggaacag caacaaccuc     1380

gacagcaagg ugggcggcaa cuacaacuac cuguaccggc uguuccggaa gagcaaccug     1440

aagcccuucg agcgggacau cagcaccgag aucuaccaag ccggcuccac cccuugcaac     1500

ggcguggagg gcuucaacug cuacuucccu cugcagagcu acggcuucca gcccaccaac     1560

ggcgugggcu accagcccua ccggguggug gugcugagcu ucgagcugcu gcacgcccca     1620

gccaccgugu guggccccaa gaagagcacc aaccugguga agaacaagug cgugaacuuc     1680

aacuucaacg gccuuaccgg caccggcgug cugaccgaga gcaacaagaa auuccugccc     1740

uuucagcagu ucggccggga caucgccgac accaccgacg cugugcggga uccccagacc     1800

cuggagaucc uggacaucac cccuugcagc uucggcggcg ugagcgugau caccccaggc     1860

accaacacca gcaaccaggu ggccgugcug uaccaggacg ugaacugcac cgaggugccc     1920

guggccaucc acgccgacca gcugacaccc accuggcggg ucuacagcac cggcagcaac     1980

guguuccaga cccgggccgg uugccugauc ggcgccgagc acgugaacaa cagcuacgag     2040

ugcgacaucc ccaucggcgc cggcaucugu gccagcuacc agacccagac caauucaccc     2100

ggcagcggcg gcagcguggc cagccagagc aucaucgccu acaccaugag ccugggcgcc     2160

gagaacagcg uggccuacag caacaacagc aucgccaucc ccaccaacuu caccaucagc     2220

gugaccaccg agauucugcc cgugagcaug accaagacca gcguggacug caccauguac     2280

aucugcggcg acagcaccga gugcagcaac cugcugcugc aguacggcag cuucugcacc     2340

cagcugaacc gggcccugac cggcaucgcc guggagcagg acaagaacac ccaggaggug     2400

uucgcccagg ugaagcagau cuacaagacc ccucccauca aggacuucgg cggcuucaac     2460

uucagccaga uccugcccga ccccagcaag cccagcaagc ggagcuucau cgaggaccug     2520

cuguucaaca aggugacccu agccgacgcc ggcuucauca agcaguacgg cgacugccuc     2580

ggcgacauag ccgcccggga ccugaucugc gcccagaagu ucaacggccu gaccgugcug     2640

ccuccccugc ugaccgacga gaugaucgcc caguacacca gcgcccuguu agccggaacc     2700

aucaccagcg gcuggacuuu cggcgcugga gccgcucugc agauccccuu cgccaugcag     2760

auggccuacc gguucaacgg caucggcgug acccagaacg ugcuguacga gaaccagaag     2820

cugaucgcca accaguucaa cagcgccauc ggcaagaucc aggacagccu gagcagcacc     2880

gcuagcgccc ugggcaagcu gcaggacgug gugaaccaga acgcccaggc ccugaacacc     2940

cuggugaagc agcugagcag caacuucggc gccaucagca gcgugcugaa cgacauccug     3000

agccggggcg gcggcggcga ggccgaggug cagaucgacc ggcugaucac uggccggcug     3060

cagagccugc agaccuacgu gacccagcag cugauccggg ccgccgagau ucgggccagc     3120

gccaaccugg ccgccaccaa gaugagcgag ugcgugcugg gccagagcaa gcggguggac     3180

uucugcggca agggcuacca ccugaugagc uuuccccaga gcgcacccca cggaguggug     3240

uuccugcacg ugaccuacgu gcccgcccag gagaagaacu ucaccaccgc cccagccauc     3300

ugccacgacg gcaaggccca cuuuccccgg gagggcgugu ucgugagcaa cggcacccac     3360

ugguucguga cccagcggaa cuucuacgag ccccagauca ucaccaccga caacaccuuc     3420

gugagcggca acugcgacgu ggugaucggc aucgugaaca acaccgugua cgauccccug     3480

cagcccgagc uggacagcuu caaggaggag cuggacaagu acuucaagaa ucacaccagc     3540

cccgacgugg accugggcga caucagcggc aucaacgcca gcguggugaa cauccagaag     3600

gagaucgauc ggcugaacga gguggccaag aaccugaacg agagccugau cgaccugcag     3660

gagcugggca aguacgagca guacaucaag uggcccuggu acaucuggcu gggcuucauc     3720

gccggccuga ucgccaucgu gauggugacc aucaugcugu gcugcaugac cagcugcugc     3780

agcugccuga agggcuguug cagcugcggc agcugcugca aguucgacga ggacgacuga     3840

uaauaggcug gagccucggu ggccuagcuu cuugccccuu gggccucccc ccagccccuc     3900

cuccccuucc ugcacccgua cccccguggu cuuugaauaa agucugagug ggcggc         3956


<210>  7
<211>  3780
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
auguucgugu uccuggugcu gcugccccug gugagcagcc agugcgugaa ccugaccacc       60

cggacccagc ugccaccagc cuacaccaac agcuucaccc ggggcgucua cuaccccgac      120

aagguguucc ggagcagcgu ccugcacagc acccaggacc uguuccugcc cuucuucagc      180

aacgugaccu gguuccacgc cauccacgug agcggcacca acggcaccaa gcgguucgac      240

aaccccgugc ugcccuucaa cgacggcgug uacuucgcca gcaccgagaa gagcaacauc      300

auccggggcu ggaucuucgg caccacccug gacagcaaga cccagagccu gcugaucgug      360

aauaacgcca ccaacguggu gaucaaggug ugcgaguucc aguucugcaa cgaccccuuc      420

cugggcgugu acuaccacaa gaacaacaag agcuggaugg agagcgaguu ccggguguac      480

agcagcgcca acaacugcac cuucgaguac gugagccagc ccuuccugau ggaccuggag      540

ggcaagcagg gcaacuucaa gaaccugcgg gaguucgugu ucaagaacau cgacggcuac      600

uucaagaucu acagcaagca caccccaauc aaccuggugc gggaucugcc ccagggcuuc      660

ucagcccugg agccccuggu ggaccugccc aucggcauca acaucacccg guuccagacc      720

cugcuggccc ugcaccggag cuaccugacc ccaggcgaca gcagcagcgg guggacagca      780

ggcgcggcug cuuacuacgu gggcuaccug cagccccgga ccuuccugcu gaaguacaac      840

gagaacggca ccaucaccga cgccguggac ugcgcccugg acccucugag cgagaccaag      900

ugcacccuga agagcuucac cguggagaag ggcaucuacc agaccagcaa cuuccgggug      960

cagcccaccg agagcaucgu gcgguucccc aacaucacca accugugccc cuucggcgag     1020

guguucaacg ccacccgguu cgccagcgug uacgccugga accggaagcg gaucagcaac     1080

ugcguggccg acuacagcgu gcuguacaac agcgccagcu ucagcaccuu caagugcuac     1140

ggcgugagcc ccaccaagcu gaacgaccug ugcuucacca acguguacgc cgacagcuuc     1200

gugauccgug gcgacgaggu gcggcagauc gcacccggcc agacaggcaa gaucgccgac     1260

uacaacuaca agcugcccga cgacuucacc ggcugcguga ucgccuggaa cagcaacaac     1320

cucgacagca aggugggcgg caacuacaac uaccuguacc ggcuguuccg gaagagcaac     1380

cugaagcccu ucgagcggga caucagcacc gagaucuacc aagccggcuc caccccuugc     1440

aacggcgugg agggcuucaa cugcuacuuc ccucugcaga gcuacggcuu ccagcccacc     1500

aacggcgugg gcuaccagcc cuaccgggug guggugcuga gcuucgagcu gcugcacgcc     1560

ccagccaccg uguguggccc caagaagagc accaaccugg ugaagaacaa gugcgugaac     1620

uucaacuuca acggccuuac cggcaccggc gugcugaccg agagcaacaa gaaauuccug     1680

cccuuucagc aguucggccg ggacaucgcc gacaccaccg acgcugugcg ggauccccag     1740

acccuggaga uccuggacau caccccuugc agcuucggcg gcgugagcgu gaucacccca     1800

ggcaccaaca ccagcaacca gguggccgug cuguaccagg acgugaacug caccgaggug     1860

cccguggcca uccacgccga ccagcugaca cccaccuggc gggucuacag caccggcagc     1920

aacguguucc agacccgggc cgguugccug aucggcgccg agcacgugaa caacagcuac     1980

gagugcgaca uccccaucgg cgccggcauc ugugccagcu accagaccca gaccaauuca     2040

cccggcagcg gcggcagcgu ggccagccag agcaucaucg ccuacaccau gagccugggc     2100

gccgagaaca gcguggccua cagcaacaac agcaucgcca uccccaccaa cuucaccauc     2160

agcgugacca ccgagauucu gcccgugagc augaccaaga ccagcgugga cugcaccaug     2220

uacaucugcg gcgacagcac cgagugcagc aaccugcugc ugcaguacgg cagcuucugc     2280

acccagcuga accgggcccu gaccggcauc gccguggagc aggacaagaa cacccaggag     2340

guguucgccc aggugaagca gaucuacaag accccuccca ucaaggacuu cggcggcuuc     2400

aacuucagcc agauccugcc cgaccccagc aagcccagca agcggagcuu caucgaggac     2460

cugcuguuca acaaggugac ccuagccgac gccggcuuca ucaagcagua cggcgacugc     2520

cucggcgaca uagccgcccg ggaccugauc ugcgcccaga aguucaacgg ccugaccgug     2580

cugccucccc ugcugaccga cgagaugauc gcccaguaca ccagcgcccu guuagccgga     2640

accaucacca gcggcuggac uuucggcgcu ggagccgcuc ugcagauccc cuucgccaug     2700

cagauggccu accgguucaa cggcaucggc gugacccaga acgugcugua cgagaaccag     2760

aagcugaucg ccaaccaguu caacagcgcc aucggcaaga uccaggacag ccugagcagc     2820

accgcuagcg cccugggcaa gcugcaggac guggugaacc agaacgccca ggcccugaac     2880

acccugguga agcagcugag cagcaacuuc ggcgccauca gcagcgugcu gaacgacauc     2940

cugagccggg gcggcggcgg cgaggccgag gugcagaucg accggcugau cacuggccgg     3000

cugcagagcc ugcagaccua cgugacccag cagcugaucc gggccgccga gauucgggcc     3060

agcgccaacc uggccgccac caagaugagc gagugcgugc ugggccagag caagcgggug     3120

gacuucugcg gcaagggcua ccaccugaug agcuuucccc agagcgcacc ccacggagug     3180

guguuccugc acgugaccua cgugcccgcc caggagaaga acuucaccac cgccccagcc     3240

aucugccacg acggcaaggc ccacuuuccc cgggagggcg uguucgugag caacggcacc     3300

cacugguucg ugacccagcg gaacuucuac gagccccaga ucaucaccac cgacaacacc     3360

uucgugagcg gcaacugcga cguggugauc ggcaucguga acaacaccgu guacgauccc     3420

cugcagcccg agcuggacag cuucaaggag gagcuggaca aguacuucaa gaaucacacc     3480

agccccgacg uggaccuggg cgacaucagc ggcaucaacg ccagcguggu gaacauccag     3540

aaggagaucg aucggcugaa cgagguggcc aagaaccuga acgagagccu gaucgaccug     3600

caggagcugg gcaaguacga gcaguacauc aaguggcccu gguacaucug gcugggcuuc     3660

aucgccggcc ugaucgccau cgugauggug accaucaugc ugugcugcau gaccagcugc     3720

ugcagcugcc ugaagggcug uugcagcugc ggcagcugcu gcaaguucga cgaggacgac     3780


<210>  8
<211>  1260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Gly Gly Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Gly Gly Gly Gly Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  
    1250                 1255                 1260 


<210>  9
<211>  3995
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(3995)
<223>  U is 1-methylpseudouridine

<400>  9
gggaaauaag agagaaaaga agaguaagaa gaaauauaag accccggcgc cgccaccaug       60

uucguguucc uggugcugcu gccccuggug agcagccagu gcgugaaccu gaccacccgg      120

acccagcugc caccagccua caccaacagc uucacccggg gcgucuacua ccccgacaag      180

guguuccgga gcagcguccu gcacagcacc caggaccugu uccugcccuu cuucagcaac      240

gugaccuggu uccacgccau ccacgugagc ggcaccaacg gcaccaagcg guucgacaac      300

cccgugcugc ccuucaacga cggcguguac uucgccagca ccgagaagag caacaucauc      360

cggggcugga ucuucggcac cacccuggac agcaagaccc agagccugcu gaucgugaau      420

aacgccacca acguggugau caaggugugc gaguuccagu ucugcaacga ccccuuccug      480

ggcguguacu accacaagaa caacaagagc uggauggaga gcgaguuccg gguguacagc      540

agcgccaaca acugcaccuu cgaguacgug agccagcccu uccugaugga ccuggagggc      600

aagcagggca acuucaagaa ccugcgggag uucguguuca agaacaucga cggcuacuuc      660

aagaucuaca gcaagcacac cccaaucaac cuggugcggg aucugcccca gggcuucuca      720

gcccuggagc cccuggugga ccugcccauc ggcaucaaca ucacccgguu ccagacccug      780

cuggcccugc accggagcua ccugacccca ggcgacagca gcagcgggug gacagcaggc      840

gcggcugcuu acuacguggg cuaccugcag ccccggaccu uccugcugaa guacaacgag      900

aacggcacca ucaccgacgc cguggacugc gcccuggacc cucugagcga gaccaagugc      960

acccugaaga gcuucaccgu ggagaagggc aucuaccaga ccagcaacuu ccgggugcag     1020

cccaccgaga gcaucgugcg guuccccaac aucaccaacc ugugccccuu cggcgaggug     1080

uucaacgcca cccgguucgc cagcguguac gccuggaacc ggaagcggau cagcaacugc     1140

guggccgacu acagcgugcu guacaacagc gccagcuuca gcaccuucaa gugcuacggc     1200

gugagcccca ccaagcugaa cgaccugugc uucaccaacg uguacgccga cagcuucgug     1260

auccguggcg acgaggugcg gcagaucgca cccggccaga caggcaagau cgccgacuac     1320

aacuacaagc ugcccgacga cuucaccggc ugcgugaucg ccuggaacag caacaaccuc     1380

gacagcaagg ugggcggcaa cuacaacuac cuguaccggc uguuccggaa gagcaaccug     1440

aagcccuucg agcgggacau cagcaccgag aucuaccaag ccggcuccac cccuugcaac     1500

ggcguggagg gcuucaacug cuacuucccu cugcagagcu acggcuucca gcccaccaac     1560

ggcgugggcu accagcccua ccggguggug gugcugagcu ucgagcugcu gcacgcccca     1620

gccaccgugu guggccccaa gaagagcacc aaccugguga agaacaagug cgugaacuuc     1680

aacuucaacg gccuuaccgg caccggcgug cugaccgaga gcaacaagaa auuccugccc     1740

uuucagcagu ucggccggga caucgccgac accaccgacg cugugcggga uccccagacc     1800

cuggagaucc uggacaucac cccuugcagc uucggcggcg ugagcgugau caccccaggc     1860

accaacacca gcaaccaggu ggccgugcug uaccaggacg ugaacugcac cgaggugccc     1920

guggccaucc acgccgacca gcugacaccc accuggcggg ucuacagcac cggcagcaac     1980

guguuccaga cccgggccgg uugccugauc ggcgccgagc acgugaacaa cagcuacgag     2040

ugcgacaucc ccaucggcgc cggcaucugu gccagcuacc agacccagac caauucaccc     2100

cggagggcaa ggagcguggc cagccagagc aucaucgccu acaccaugag ccugggcgcc     2160

gagaacagcg uggccuacag caacaacagc aucgccaucc ccaccaacuu caccaucagc     2220

gugaccaccg agauucugcc cgugagcaug accaagacca gcguggacug caccauguac     2280

aucugcggcg acagcaccga gugcagcaac cugcugcugc aguacggcag cuucugcacc     2340

cagcugaacc gggcccugac cggcaucgcc guggagcagg acaagaacac ccaggaggug     2400

uucgcccagg ugaagcagau cuacaagacc ccucccauca aggacuucgg cggcuucaac     2460

uucagccaga uccugcccga ccccagcaag cccagcaagc ggagcuucau cgaggaccug     2520

cuguucaaca aggugacccu agccgacgcc ggcuucauca agcaguacgg cgacugccuc     2580

ggcgacauag ccgcccggga ccugaucugc gcccagaagu ucaacggccu gaccgugcug     2640

ccuccccugc ugaccgacga gaugaucgcc caguacacca gcgcccuguu agccggaacc     2700

aucaccagcg gcuggacuuu cggcgcugga gccgcucugc agauccccuu cgccaugcag     2760

auggccuacc gguucaacgg caucggcgug acccagaacg ugcuguacga gaaccagaag     2820

cugaucgcca accaguucaa cagcgccauc ggcaagaucc aggacagccu gagcagcacc     2880

gcuagcgccc ugggcaagcu gcaggacgug gugaaccaga acgcccaggc ccugaacacc     2940

cuggugaagc agcugagcag caacuucggc gccaucagca gcgugcugaa cgacauccug     3000

agccggcugg acccucccga ggccgaggug cagaucgacc ggcugaucac uggccggcug     3060

cagagccugc agaccuacgu gacccagcag cugauccggg ccgccgagau ucgggccagc     3120

gccaaccugg ccgccaccaa gaugagcgag ugcgugcugg gccagagcaa gcggguggac     3180

uucugcggca agggcuacca ccugaugagc uuuccccaga gcgcacccca cggaguggug     3240

uuccugcacg ugaccuacgu gcccgcccag gagaagaacu ucaccaccgc cccagccauc     3300

ugccacgacg gcaaggccca cuuuccccgg gagggcgugu ucgugagcaa cggcacccac     3360

ugguucguga cccagcggaa cuucuacgag ccccagauca ucaccaccga caacaccuuc     3420

gugagcggca acugcgacgu ggugaucggc aucgugaaca acaccgugua cgauccccug     3480

cagcccgagc uggacagcuu caaggaggag cuggacaagu acuucaagaa ucacaccagc     3540

cccgacgugg accugggcga caucagcggc aucaacgcca gcguggugaa cauccagaag     3600

gagaucgauc ggcugaacga gguggccaag aaccugaacg agagccugau cgaccugcag     3660

gagcugggca aguacgagca guacaucaag uggcccuggu acaucuggcu gggcuucauc     3720

gccggccuga ucgccaucgu gauggugacc aucaugcugu gcugcaugac cagcugcugc     3780

agcugccuga agggcuguug cagcugcggc agcugcugca aguucgacga ggacgacagc     3840

gagcccgugc ugaagggcgu gaagcugcac uacaccugau aauaggcugg agccucggug     3900

gccuagcuuc uugccccuug ggccuccccc cagccccucc uccccuuccu gcacccguac     3960

ccccgugguc uuugaauaaa gucugagugg gcggc                                3995


<210>  10
<211>  3956
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(3956)
<223>  U is 1-methylpseudouridine

<400>  10
gggaaauaag agagaaaaga agaguaagaa gaaauauaag accccggcgc cgccaccaug       60

uucguguucc uggugcugcu gccccuggug agcagccagu gcgugaaccu gaccacccgg      120

acccagcugc caccagccua caccaacagc uucacccggg gcgucuacua ccccgacaag      180

guguuccgga gcagcguccu gcacagcacc caggaccugu uccugcccuu cuucagcaac      240

gugaccuggu uccacgccau ccacgugagc ggcaccaacg gcaccaagcg guucgacaac      300

cccgugcugc ccuucaacga cggcguguac uucgccagca ccgagaagag caacaucauc      360

cggggcugga ucuucggcac cacccuggac agcaagaccc agagccugcu gaucgugaau      420

aacgccacca acguggugau caaggugugc gaguuccagu ucugcaacga ccccuuccug      480

ggcguguacu accacaagaa caacaagagc uggauggaga gcgaguuccg gguguacagc      540

agcgccaaca acugcaccuu cgaguacgug agccagcccu uccugaugga ccuggagggc      600

aagcagggca acuucaagaa ccugcgggag uucguguuca agaacaucga cggcuacuuc      660

aagaucuaca gcaagcacac cccaaucaac cuggugcggg aucugcccca gggcuucuca      720

gcccuggagc cccuggugga ccugcccauc ggcaucaaca ucacccgguu ccagacccug      780

cuggcccugc accggagcua ccugacccca ggcgacagca gcagcgggug gacagcaggc      840

gcggcugcuu acuacguggg cuaccugcag ccccggaccu uccugcugaa guacaacgag      900

aacggcacca ucaccgacgc cguggacugc gcccuggacc cucugagcga gaccaagugc      960

acccugaaga gcuucaccgu ggagaagggc aucuaccaga ccagcaacuu ccgggugcag     1020

cccaccgaga gcaucgugcg guuccccaac aucaccaacc ugugccccuu cggcgaggug     1080

uucaacgcca cccgguucgc cagcguguac gccuggaacc ggaagcggau cagcaacugc     1140

guggccgacu acagcgugcu guacaacagc gccagcuuca gcaccuucaa gugcuacggc     1200

gugagcccca ccaagcugaa cgaccugugc uucaccaacg uguacgccga cagcuucgug     1260

auccguggcg acgaggugcg gcagaucgca cccggccaga caggcaagau cgccgacuac     1320

aacuacaagc ugcccgacga cuucaccggc ugcgugaucg ccuggaacag caacaaccuc     1380

gacagcaagg ugggcggcaa cuacaacuac cuguaccggc uguuccggaa gagcaaccug     1440

aagcccuucg agcgggacau cagcaccgag aucuaccaag ccggcuccac cccuugcaac     1500

ggcguggagg gcuucaacug cuacuucccu cugcagagcu acggcuucca gcccaccaac     1560

ggcgugggcu accagcccua ccggguggug gugcugagcu ucgagcugcu gcacgcccca     1620

gccaccgugu guggccccaa gaagagcacc aaccugguga agaacaagug cgugaacuuc     1680

aacuucaacg gccuuaccgg caccggcgug cugaccgaga gcaacaagaa auuccugccc     1740

uuucagcagu ucggccggga caucgccgac accaccgacg cugugcggga uccccagacc     1800

cuggagaucc uggacaucac cccuugcagc uucggcggcg ugagcgugau caccccaggc     1860

accaacacca gcaaccaggu ggccgugcug uaccaggacg ugaacugcac cgaggugccc     1920

guggccaucc acgccgacca gcugacaccc accuggcggg ucuacagcac cggcagcaac     1980

guguuccaga cccgggccgg uugccugauc ggcgccgagc acgugaacaa cagcuacgag     2040

ugcgacaucc ccaucggcgc cggcaucugu gccagcuacc agacccagac caauucaccc     2100

ggcagcggcg gcagcguggc cagccagagc aucaucgccu acaccaugag ccugggcgcc     2160

gagaacagcg uggccuacag caacaacagc aucgccaucc ccaccaacuu caccaucagc     2220

gugaccaccg agauucugcc cgugagcaug accaagacca gcguggacug caccauguac     2280

aucugcggcg acagcaccga gugcagcaac cugcugcugc aguacggcag cuucugcacc     2340

cagcugaacc gggcccugac cggcaucgcc guggagcagg acaagaacac ccaggaggug     2400

uucgcccagg ugaagcagau cuacaagacc ccucccauca aggacuucgg cggcuucaac     2460

uucagccaga uccugcccga ccccagcaag cccagcaagc ggagcuucau cgaggaccug     2520

cuguucaaca aggugacccu agccgacgcc ggcuucauca agcaguacgg cgacugccuc     2580

ggcgacauag ccgcccggga ccugaucugc gcccagaagu ucaacggccu gaccgugcug     2640

ccuccccugc ugaccgacga gaugaucgcc caguacacca gcgcccuguu agccggaacc     2700

aucaccagcg gcuggacuuu cggcgcugga gccgcucugc agauccccuu cgccaugcag     2760

auggccuacc gguucaacgg caucggcgug acccagaacg ugcuguacga gaaccagaag     2820

cugaucgcca accaguucaa cagcgccauc ggcaagaucc aggacagccu gagcagcacc     2880

gcuagcgccc ugggcaagcu gcaggacgug gugaaccaga acgcccaggc ccugaacacc     2940

cuggugaagc agcugagcag caacuucggc gccaucagca gcgugcugaa cgacauccug     3000

agccggggcg gcggcggcga ggccgaggug cagaucgacc ggcugaucac uggccggcug     3060

cagagccugc agaccuacgu gacccagcag cugauccggg ccgccgagau ucgggccagc     3120

gccaaccugg ccgccaccaa gaugagcgag ugcgugcugg gccagagcaa gcggguggac     3180

uucugcggca agggcuacca ccugaugagc uuuccccaga gcgcacccca cggaguggug     3240

uuccugcacg ugaccuacgu gcccgcccag gagaagaacu ucaccaccgc cccagccauc     3300

ugccacgacg gcaaggccca cuuuccccgg gagggcgugu ucgugagcaa cggcacccac     3360

ugguucguga cccagcggaa cuucuacgag ccccagauca ucaccaccga caacaccuuc     3420

gugagcggca acugcgacgu ggugaucggc aucgugaaca acaccgugua cgauccccug     3480

cagcccgagc uggacagcuu caaggaggag cuggacaagu acuucaagaa ucacaccagc     3540

cccgacgugg accugggcga caucagcggc aucaacgcca gcguggugaa cauccagaag     3600

gagaucgauc ggcugaacga gguggccaag aaccugaacg agagccugau cgaccugcag     3660

gagcugggca aguacgagca guacaucaag uggcccuggu acaucuggcu gggcuucauc     3720

gccggccuga ucgccaucgu gauggugacc aucaugcugu gcugcaugac cagcugcugc     3780

agcugccuga agggcuguug cagcugcggc agcugcugca aguucgacga ggacgacuga     3840

uaauaggcug gagccucggu ggccuagcuu cuugccccuu gggccucccc ccagccccuc     3900

cuccccuucc ugcacccgua cccccguggu cuuugaauaa agucugagug ggcggc         3956


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Gly Gly Gly Gly 
1               


<210>  12
<211>  47
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210>  13
<211>  119
<212>  RNA
<213>  SARS-CoV-2 Wuhan-Hu-1 (USA-WA1/2020 isolate ) Spike (S) Protein

<400>  13
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccgu ggucuuugaa uaaagucuga gugggcggc       119


<210>  14

<400>  14
000

<210>  15
<211>  1273
<212>  PRT
<213>  Unknown

<220>
<223>  SARS-CoV Spike (S) Protein

<400>  15

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  16
<211>  3768
<212>  RNA
<213>  Unknown

<220>
<223>  SARS-CoV Spike (S) Protein

<400>  16
auguuuauuu ucuuauuauu ucuuacucuc acuaguggua gugaccuuga ccggugcacc       60

acuuuugaug auguucaagc uccuaauuac acucaacaua cuucaucuau gagggggguu      120

uacuauccug augaaauuuu uagaucagac acucuuuauu uaacucagga uuuauuucuu      180

ccauuuuauu cuaauguuac aggguuucau acuauuaauc auacguuugg caacccuguc      240

auaccuuuua aggaugguau uuauuuugcu gccacagaga aaucaaaugu uguccguggu      300

uggguuuuug guucuaccau gaacaacaag ucacagucgg ugauuauuau uaacaauucu      360

acuaauguug uuauacgagc auguaacuuu gaauugugug acaacccuuu cuuugcuguu      420

ucuaaaccca uggguacaca gacacauacu augauauucg auaaugcauu uaauugcacu      480

uucgaguaca uaucugaugc cuuuucgcuu gauguuucag aaaagucagg uaauuuuaaa      540

cacuuacgag aguuuguguu uaaaaauaaa gauggguuuc ucuauguuua uaagggcuau      600

caaccuauag auguaguucg ugaucuaccu ucugguuuua acacuuugaa accuauuuuu      660

aaguugccuc uugguauuaa cauuacaaau uuuagagcca uucuuacagc cuuuucaccu      720

gcucaagaca uuuggggcac gucagcugca gccuauuuug uuggcuauuu aaagccaacu      780

acauuuaugc ucaaguauga ugaaaauggu acaaucacag augcuguuga uuguucucaa      840

aauccacuug cugaacucaa augcucuguu aagagcuuug agauugacaa aggaauuuac      900

cagaccucua auuucagggu uguucccuca ggagauguug ugagauuccc uaauauuaca      960

aacuuguguc cuuuuggaga gguuuuuaau gcuacuaaau ucccuucugu cuaugcaugg     1020

gagagaaaaa aaauuucuaa uuguguugcu gauuacucug ugcucuacaa cucaacauuu     1080

uuuucaaccu uuaaguguua uggcguuucu gccacuaagu ugaaugaucu uugcuucucc     1140

aaugucuaug cagauucuuu uguagucaag ggagaugaug uaagacaaau agcgccagga     1200

caaacuggug uuauugcuga uuauaauuau aaauugccag augauuucau ggguuguguc     1260

cuugcuugga auacuaggaa cauugaugcu acuucaacug guaauuauaa uuauaaauau     1320

agguaucuua gacauggcaa gcuuaggccc uuugagagag acauaucuaa ugugccuuuc     1380

uccccugaug gcaaaccuug caccccaccu gcucuuaauu guuauuggcc auuaaaugau     1440

uaugguuuuu acaccacuac uggcauuggc uaccaaccuu acagaguugu aguacuuucu     1500

uuugaacuuu uaaaugcacc ggccacgguu uguggaccaa aauuauccac ugaccuuauu     1560

aagaaccagu gugucaauuu uaauuuuaau ggacucacug guacuggugu guuaacuccu     1620

ucuucaaaga gauuucaacc auuucaacaa uuuggccgug auguuucuga uuucacugau     1680

uccguucgag auccuaaaac aucugaaaua uuagacauuu caccuugcuc uuuugggggu     1740

guaaguguaa uuacaccugg aacaaaugcu ucaucugaag uugcuguucu auaucaagau     1800

guuaacugca cugauguuuc uacagcaauu caugcagauc aacucacacc agcuuggcgc     1860

auauauucua cuggaaacaa uguauuccag acucaagcag gcugucuuau aggagcugag     1920

caugucgaca cuucuuauga gugcgacauu ccuauuggag cuggcauuug ugcuaguuac     1980

cauacaguuu cuuuauuacg uaguacuagc caaaaaucua uuguggcuua uacuaugucu     2040

uuaggugcug auaguucaau ugcuuacucu aauaacacca uugcuauacc uacuaacuuu     2100

ucaauuagca uuacuacaga aguaaugccu guuucuaugg cuaaaaccuc cguagauugu     2160

aauauguaca ucugcggaga uucuacugaa ugugcuaauu ugcuucucca auaugguagc     2220

uuuugcacac aacuaaaucg ugcacucuca gguauugcug cugaacagga ucgcaacaca     2280

cgugaagugu ucgcucaagu caaacaaaug uacaaaaccc caacuuugaa auauuuuggu     2340

gguuuuaauu uuucacaaau auuaccugac ccucuaaagc caacuaagag gucuuuuauu     2400

gaggacuugc ucuuuaauaa ggugacacuc gcugaugcug gcuucaugaa gcaauauggc     2460

gaaugccuag gugauauuaa ugcuagagau cucauuugug cgcagaaguu caauggacuu     2520

acaguguugc caccucugcu cacugaugau augauugcug ccuacacugc ugcucuaguu     2580

agugguacug ccacugcugg auggacauuu ggugcuggcg cugcucuuca aauaccuuuu     2640

gcuaugcaaa uggcauauag guucaauggc auuggaguua cccaaaaugu ucucuaugag     2700

aaccaaaaac aaaucgccaa ccaauuuaac aaggcgauua gucaaauuca agaaucacuu     2760

acaacaacau caacugcauu gggcaagcug caagacguug uuaaccagaa ugcucaagca     2820

uuaaacacac uuguuaaaca acuuagcucu aauuuuggug caauuucaag ugugcuaaau     2880

gauauccuuu cgcgacuuga uaaagucgag gcggagguac aaauugacag guuaauuaca     2940

ggcagacuuc aaagccuuca aaccuaugua acacaacaac uaaucagggc ugcugaaauc     3000

agggcuucug cuaaucuugc ugcuacuaaa augucugagu guguucuugg acaaucaaaa     3060

agaguugacu uuuguggaaa gggcuaccac cuuauguccu ucccacaagc agccccgcau     3120

gguguugucu uccuacaugu cacguaugug ccaucccagg agaggaacuu caccacagcg     3180

ccagcaauuu gucaugaagg caaagcauac uucccucgug aagguguuuu uguguuuaau     3240

ggcacuucuu gguuuauuac acagaggaac uucuuuucuc cacaaauaau uacuacagac     3300

aauacauuug ucucaggaaa uugugauguc guuauuggca ucauuaacaa cacaguuuau     3360

gauccucugc aaccugagcu ugacucauuc aaagaagagc uggacaagua cuucaaaaau     3420

cauacaucac cagauguuga ucuuggcgac auuucaggca uuaacgcuuc ugucgucaac     3480

auucaaaaag aaauugaccg ccucaaugag gucgcuaaaa auuuaaauga aucacucauu     3540

gaccuucaag aauugggaaa auaugagcaa uauauuaaau ggccuuggua uguuuggcuc     3600

ggcuucauug cuggacuaau ugccaucguc augguuacaa ucuugcuuug uugcaugacu     3660

aguuguugca guugccucaa gggugcaugc ucuugugguu cuugcugcaa guuugaugag     3720

gaugacucug agccaguucu caaggguguc aaauuacauu acacauaa                  3768


<210>  17
<211>  1255
<212>  PRT
<213>  Unknown

<220>
<223>  SARS-CoV Spike (S) Protein

<400>  17

Met Phe Ile Phe Leu Leu Phe Leu Thr Leu Thr Ser Gly Ser Asp Leu 
1               5                   10                  15      


Asp Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln 
            20                  25                  30          


His Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg 
        35                  40                  45              


Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser 
    50                  55                  60                  


Asn Val Thr Gly Phe His Thr Ile Asn His Thr Phe Gly Asn Pro Val 
65                  70                  75                  80  


Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn 
                85                  90                  95      


Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln 
            100                 105                 110         


Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys 
        115                 120                 125             


Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met 
    130                 135                 140                 


Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr 
145                 150                 155                 160 


Phe Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser 
                165                 170                 175     


Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly 
            180                 185                 190         


Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp 
        195                 200                 205             


Leu Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu 
    210                 215                 220                 


Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Pro 
225                 230                 235                 240 


Ala Gln Asp Ile Trp Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr 
                245                 250                 255     


Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys 
        275                 280                 285             


Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser 
                325                 330                 335     


Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser 
            420                 425                 430         


Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu 
        435                 440                 445             


Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly 
    450                 455                 460                 


Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp 
465                 470                 475                 480 


Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg 
    530                 535                 540                 


Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp 
545                 550                 555                 560 


Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Ala Ser Ser 
            580                 585                 590         


Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp Val Ser Thr 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Ala Trp Arg Ile Tyr Ser Thr 
    610                 615                 620                 


Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr His Thr Val Ser Leu Leu Arg Ser Thr Ser Gln Lys 
            660                 665                 670         


Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala 
        675                 680                 685             


Tyr Ser Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile 
    690                 695                 700                 


Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys 
705                 710                 715                 720 


Asn Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu 
                725                 730                 735     


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile 
            740                 745                 750         


Ala Ala Glu Gln Asp Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys 
        755                 760                 765             


Gln Met Tyr Lys Thr Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn Phe 
    770                 775                 780                 


Ser Gln Ile Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile 
785                 790                 795                 800 


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met 
                805                 810                 815     


Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile 
            820                 825                 830         


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
        835                 840                 845             


Asp Asp Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala 
    850                 855                 860                 


Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
865                 870                 875                 880 


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
                885                 890                 895     


Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala 
            900                 905                 910         


Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu Gly 
        915                 920                 925             


Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
    930                 935                 940                 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
945                 950                 955                 960 


Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
                965                 970                 975     


Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln 
            980                 985                 990         


Gln Leu Ile Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
        995                 1000                 1005             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1010                 1015                 1020             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ala Ala 
    1025                 1030                 1035             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ser Gln 
    1040                 1045                 1050             


Glu Arg  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Glu Gly Lys 
    1055                 1060                 1065             


Ala Tyr  Phe Pro Arg Glu Gly  Val Phe Val Phe Asn  Gly Thr Ser 
    1070                 1075                 1080             


Trp Phe  Ile Thr Gln Arg Asn  Phe Phe Ser Pro Gln  Ile Ile Thr 
    1085                 1090                 1095             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1100                 1105                 1110             


Ile Ile  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1115                 1120                 1125             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1130                 1135                 1140             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1145                 1150                 1155             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1160                 1165                 1170             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1175                 1180                 1185             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Val Trp Leu  Gly Phe Ile 
    1190                 1195                 1200             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Leu  Leu Cys Cys 
    1205                 1210                 1215             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Ala Cys  Ser Cys Gly 
    1220                 1225                 1230             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1235                 1240                 1245             


Gly Val  Lys Leu His Tyr Thr  
    1250                 1255 


<210>  18
<211>  4062
<212>  RNA
<213>  Unknown

<220>
<223>  MERS-CoV Spike (S) Protein

<400>  18
augauacacu caguguuucu acugauguuc uuguuaacac cuacagaaag uuacguugau       60

guagggccag auucuguuaa gucugcuugu auugagguug auauacaaca gacuuucuuu      120

gauaaaacuu ggccuaggcc aauugauguu ucuaaggcug acgguauuau auacccucaa      180

ggccguacau auucuaacau aacuaucacu uaucaagguc uuuuucccua ucagggagac      240

cauggugaua uguauguuua cucugcagga caugcuacag gcacaacucc acaaaaguug      300

uuuguagcua acuauucuca ggacgucaaa caguucgcua auggguuugu cguccguaua      360

ggagcagcug ccaauuccac uggcacuguu auuauuagcc caucuaccag cgcuacuaua      420

cgaaaaauuu acccugcuuu uaugcugggu ucuucaguug guaauuucuc agaugguaaa      480

augggccgcu ucuucaauca uacucuaguc cuuuugcccg auggaugugg cacuuuacuu      540

agagcuuuuu auuguauucu agagccucgc ucuggaaauc auuguccugc uggcaauucc      600

uauacuucuu uugccacuua ucacacuccu gcaacagauu guucugaugg caauuacaau      660

cguaaugcca gucugaacuc uuuuaaggag uauuuuaauu uacguaacug caccuuuaug      720

uacacuuaua acauuaccga agaugagauu uuagaguggu uuggcauuac acaaacugcu      780

caagguguuc accucuucuc aucucgguau guugauuugu acggcggcaa uauguuucaa      840

uuugccaccu ugccuguuua ugauacuauu aaguauuacu cuaucauucc ucacaguauu      900

cguucuaucc aaagugauag aaaagcuugg gcugccuucu acguauauaa acuucaaccg      960

uuaacuuucc uguuggauuu uucuguugau gguuauauac gcagagcuau agacuguggu     1020

uuuaaugauu ugucacaacu ccacugcuca uaugaauccu ucgauguuga aucuggaguu     1080

uauucaguuu cgucuuucga agcaaaaccu ucuggcucag uuguggaaca ggcugaaggu     1140

guugaaugug auuuuucacc ucuucugucu ggcacaccuc cucagguuua uaauuucaag     1200

cguuugguuu uuaccaauug caauuauaau cuuaccaaau ugcuuucacu uuuuucugug     1260

aaugauuuua cuuguaguca aauaucucca gcagcaauug cuagcaacug uuauucuuca     1320

cugauuuugg auuacuuuuc auacccacuu aguaugaaau ccgaucucag uguuaguucu     1380

gcugguccaa uaucccaguu uaauuauaaa caguccuuuu cuaaucccac auguuugauu     1440

uuagcgacug uuccucauaa ccuuacuacu auuacuaagc cucuuaagua cagcuauauu     1500

aacaagugcu cucgucuucu uucugaugau cguacugaag uaccucaguu agugaacgcu     1560

aaucaauacu cacccugugu auccauuguc ccauccacug ugugggaaga cggugauuau     1620

uauaggaaac aacuaucucc acuugaaggu gguggcuggc uuguugcuag uggcucaacu     1680

guugccauga cugagcaauu acagaugggc uuugguauua caguucaaua ugguacagac     1740

accaauagug uuugccccaa gcuugaauuu gcuaaugaca caaaaauugc cucucaauua     1800

ggcaauugcg uggaauauuc ccucuauggu guuucgggcc gugguguuuu ucagaauugc     1860

acagcuguag guguucgaca gcagcgcuuu guuuaugaug cauaccagaa uuuaguuggc     1920

uauuauucug augauggcaa cuacuacugu uugcgugcuu guguuagugu uccuguuucu     1980

gucaucuaug auaaagaaac uaaaacccac gcuacucuau uugguagugu ugcaugugaa     2040

cacauuucuu cuaccauguc ucaauacucc cguucuacgc gaucaaugcu uaaacggcga     2100

gauucuacau auggcccccu ucagacaccu guugguugug uccuaggacu uguuaauucc     2160

ucuuuguucg uagaggacug caaguugccu cucggucaau cucucugugc ucuuccugac     2220

acaccuagua cucucacacc ucgcagugug cgcucuguuc caggugaaau gcgcuuggca     2280

uccauugcuu uuaaucaucc cauucagguu gaucaacuua auaguaguua uuuuaaauua     2340

aguauaccca cuaauuuuuc cuuuggugug acucaggagu acauucagac aaccauucag     2400

aaaguuacug uugauuguaa acaguacguu ugcaaugguu uccagaagug ugagcaauua     2460

cugcgcgagu auggccaguu uuguuccaaa auaaaccagg cucuccaugg ugccaauuua     2520

cgccaggaug auucuguacg uaauuuguuu gcgagcguga aaagcucuca aucaucuccu     2580

aucauaccag guuuuggagg ugacuuuaau uugacacuuc uagaaccugu uucuauaucu     2640

acuggcaguc guagugcacg uagugcuauu gaggauuugc uauuugacaa agucacuaua     2700

gcugauccug guuauaugca agguuacgau gauuguaugc agcaaggucc agcaucagcu     2760

cgugaucuua uuugugcuca auauguggcu gguuauaaag uauuaccucc ucuuauggau     2820

guuaauaugg aagccgcgua uacuucaucu uugcuuggca gcauagcagg uguuggcugg     2880

acugcuggcu uauccuccuu ugcugcuauu ccauuugcac agaguaucuu uuauagguua     2940

aacgguguug gcauuacuca acagguucuu ucagagaacc aaaagcuuau ugccaauaag     3000

uuuaaucagg cucugggagc uaugcaaaca ggcuucacua caacuaauga agcuuuucgg     3060

aagguucagg augcugugaa caacaaugca caggcucuau ccaaauuagc uagcgagcua     3120

ucuaauacuu uuggugcuau uuccgccucu auuggagaca ucauacaacg ucuugauguu     3180

cucgaacagg acgcccaaau agacagacuu auuaauggcc guuugacaac acuaaaugcu     3240

uuuguugcac agcagcuugu ucguuccgaa ucagcugcuc uuuccgcuca auuggcuaaa     3300

gauaaaguca augagugugu caaggcacaa uccaagcguu cuggauuuug uggucaaggc     3360

acacauauag uguccuuugu uguaaaugcc ccuaauggcc uuuacuucau gcauguuggu     3420

uauuacccua gcaaccacau ugagguuguu ucugcuuaug gucuuugcga ugcagcuaac     3480

ccuacuaauu guauagcccc uguuaauggc uacuuuauua aaacuaauaa cacuaggauu     3540

guugaugagu ggucauauac uggcucgucc uucuaugcac cugagcccau caccucccuu     3600

aauacuaagu auguugcacc acaugugaca uaccaaaaca uuucuacuaa ccucccuccu     3660

ccucuucucg gcaauuccac cgggauugac uuccaagaug aguuggauga guuuuucaaa     3720

aauguuagca ccaguauacc uaauuuuggu ucucuaacac agauuaauac uacauuacuc     3780

gaucuuaccu acgagauguu gucucuucaa caaguuguua aagcccuuaa ugagucuuac     3840

auagaccuua aagagcuugg caauuauacu uauuacaaca aauggccgug guacauuugg     3900

cuugguuuca uugcugggcu uguugccuua gcucuaugcg ucuucuucau acugugcugc     3960

acugguugug gcacaaacug uaugggaaaa cuuaagugua aucguuguug ugauagauac     4020

gaggaauacg accucgagcc gcauaagguu cauguucacu aa                        4062


<210>  19
<211>  1353
<212>  PRT
<213>  Unknown

<220>
<223>  MERS-CoV Spike (S) Protein

<400>  19

Met Ile His Ser Val Phe Leu Leu Met Phe Leu Leu Thr Pro Thr Glu 
1               5                   10                  15      


Ser Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu 
            20                  25                  30          


Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile 
        35                  40                  45              


Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr 
    50                  55                  60                  


Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp 
65                  70                  75                  80  


His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr 
                85                  90                  95      


Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe 
            100                 105                 110         


Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly 
        115                 120                 125             


Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr 
    130                 135                 140                 


Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys 
145                 150                 155                 160 


Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys 
                165                 170                 175     


Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly 
            180                 185                 190         


Asn His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His 
        195                 200                 205             


Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser 
    210                 215                 220                 


Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met 
225                 230                 235                 240 


Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile 
                245                 250                 255     


Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp 
            260                 265                 270         


Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp 
        275                 280                 285             


Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln 
    290                 295                 300                 


Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro 
305                 310                 315                 320 


Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala 
                325                 330                 335     


Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu 
            340                 345                 350         


Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala 
        355                 360                 365             


Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
    370                 375                 380                 


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
385                 390                 395                 400 


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
                405                 410                 415     


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
            420                 425                 430         


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
        435                 440                 445             


Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile 
    450                 455                 460                 


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
465                 470                 475                 480 


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
                485                 490                 495     


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp Arg Thr 
            500                 505                 510         


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
        515                 520                 525             


Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
    530                 535                 540                 


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
545                 550                 555                 560 


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
                565                 570                 575     


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
            580                 585                 590         


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
        595                 600                 605             


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
    610                 615                 620                 


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
625                 630                 635                 640 


Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser 
                645                 650                 655     


Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr 
            660                 665                 670         


Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln 
        675                 680                 685             


Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr 
    690                 695                 700                 


Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser 
705                 710                 715                 720 


Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys 
                725                 730                 735     


Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Arg Ser 
            740                 745                 750         


Val Pro Gly Glu Met Arg Leu Ala Ser Ile Ala Phe Asn His Pro Ile 
        755                 760                 765             


Gln Val Asp Gln Leu Asn Ser Ser Tyr Phe Lys Leu Ser Ile Pro Thr 
    770                 775                 780                 


Asn Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile Gln Thr Thr Ile Gln 
785                 790                 795                 800 


Lys Val Thr Val Asp Cys Lys Gln Tyr Val Cys Asn Gly Phe Gln Lys 
                805                 810                 815     


Cys Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe Cys Ser Lys Ile Asn 
            820                 825                 830         


Gln Ala Leu His Gly Ala Asn Leu Arg Gln Asp Asp Ser Val Arg Asn 
        835                 840                 845             


Leu Phe Ala Ser Val Lys Ser Ser Gln Ser Ser Pro Ile Ile Pro Gly 
    850                 855                 860                 


Phe Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu Pro Val Ser Ile Ser 
865                 870                 875                 880 


Thr Gly Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp 
                885                 890                 895     


Lys Val Thr Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp Asp Cys 
            900                 905                 910         


Met Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu Ile Cys Ala Gln Tyr 
        915                 920                 925             


Val Ala Gly Tyr Lys Val Leu Pro Pro Leu Met Asp Val Asn Met Glu 
    930                 935                 940                 


Ala Ala Tyr Thr Ser Ser Leu Leu Gly Ser Ile Ala Gly Val Gly Trp 
945                 950                 955                 960 


Thr Ala Gly Leu Ser Ser Phe Ala Ala Ile Pro Phe Ala Gln Ser Ile 
                965                 970                 975     


Phe Tyr Arg Leu Asn Gly Val Gly Ile Thr Gln Gln Val Leu Ser Glu 
            980                 985                 990         


Asn Gln Lys Leu Ile Ala Asn Lys  Phe Asn Gln Ala Leu  Gly Ala Met 
        995                 1000                 1005             


Gln Thr  Gly Phe Thr Thr Thr  Asn Glu Ala Phe Arg  Lys Val Gln 
    1010                 1015                 1020             


Asp Ala  Val Asn Asn Asn Ala  Gln Ala Leu Ser Lys  Leu Ala Ser 
    1025                 1030                 1035             


Glu Leu  Ser Asn Thr Phe Gly  Ala Ile Ser Ala Ser  Ile Gly Asp 
    1040                 1045                 1050             


Ile Ile  Gln Arg Leu Asp Val  Leu Glu Gln Asp Ala  Gln Ile Asp 
    1055                 1060                 1065             


Arg Leu  Ile Asn Gly Arg Leu  Thr Thr Leu Asn Ala  Phe Val Ala 
    1070                 1075                 1080             


Gln Gln  Leu Val Arg Ser Glu  Ser Ala Ala Leu Ser  Ala Gln Leu 
    1085                 1090                 1095             


Ala Lys  Asp Lys Val Asn Glu  Cys Val Lys Ala Gln  Ser Lys Arg 
    1100                 1105                 1110             


Ser Gly  Phe Cys Gly Gln Gly  Thr His Ile Val Ser  Phe Val Val 
    1115                 1120                 1125             


Asn Ala  Pro Asn Gly Leu Tyr  Phe Met His Val Gly  Tyr Tyr Pro 
    1130                 1135                 1140             


Ser Asn  His Ile Glu Val Val  Ser Ala Tyr Gly Leu  Cys Asp Ala 
    1145                 1150                 1155             


Ala Asn  Pro Thr Asn Cys Ile  Ala Pro Val Asn Gly  Tyr Phe Ile 
    1160                 1165                 1170             


Lys Thr  Asn Asn Thr Arg Ile  Val Asp Glu Trp Ser  Tyr Thr Gly 
    1175                 1180                 1185             


Ser Ser  Phe Tyr Ala Pro Glu  Pro Ile Thr Ser Leu  Asn Thr Lys 
    1190                 1195                 1200             


Tyr Val  Ala Pro His Val Thr  Tyr Gln Asn Ile Ser  Thr Asn Leu 
    1205                 1210                 1215             


Pro Pro  Pro Leu Leu Gly Asn  Ser Thr Gly Ile Asp  Phe Gln Asp 
    1220                 1225                 1230             


Glu Leu  Asp Glu Phe Phe Lys  Asn Val Ser Thr Ser  Ile Pro Asn 
    1235                 1240                 1245             


Phe Gly  Ser Leu Thr Gln Ile  Asn Thr Thr Leu Leu  Asp Leu Thr 
    1250                 1255                 1260             


Tyr Glu  Met Leu Ser Leu Gln  Gln Val Val Lys Ala  Leu Asn Glu 
    1265                 1270                 1275             


Ser Tyr  Ile Asp Leu Lys Glu  Leu Gly Asn Tyr Thr  Tyr Tyr Asn 
    1280                 1285                 1290             


Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Val 
    1295                 1300                 1305             


Ala Leu  Ala Leu Cys Val Phe  Phe Ile Leu Cys Cys  Thr Gly Cys 
    1310                 1315                 1320             


Gly Thr  Asn Cys Met Gly Lys  Leu Lys Cys Asn Arg  Cys Cys Asp 
    1325                 1330                 1335             


Arg Tyr  Glu Glu Tyr Asp Leu  Glu Pro His Lys Val  His Val His 
    1340                 1345                 1350             


<210>  20
<211>  4149
<212>  RNA
<213>  M-CoV Spike (S) Protein RNA Coding Sequence

<400>  20
uaaucuaaac augcuguucg ucuuuauuuu acuauuaccc ucuuguuuag gguauauugg       60

ugauuuuaga uguauccaga ccgugaauua uaacggcaau aaugcuucug cgccuagcau      120

uagcaccgaa gcagucgaug uuuccaaagg ucugggcacu uacuauguuu uagaucgugu      180

uuacuuaaau gccacguuau ugcuuacugg uuauuauccu guggacgguu ccaauuaucg      240

gaaucucgcg cuuacaggca cuaauaccuu aagccuuacg ugguuuaaac cacccuuucu      300

aagugaguuu aaugauggua uauuugcuaa gguccagaac cucaagacaa auacgccaac      360

aggugcaacc ucauauuuuc ccacuauagu uauagguagu uuguuuggua acacuuccua      420

uaccguaguu uuagagccau auaauaauau uauaauggcu ucuguuugua cauauaccau      480

uugucaauua ccuuacacac ccuguaagcc uaauaccaau gguaaucgug uuauuggauu      540

uuggcacaca gaugucaaac cgccgauuug ucuuuuaaag cguaauuuua cguuuaaugu      600

uaaugccccu uggcuuuauu uccauuuuua ucagcagggu gguacuuuuu augcguacua      660

ugcggauaaa ccuuccgcua cuacguuuuu guuuagugug uauauuggcg acauuuuaac      720

acaguauuuu guguuaccuu uuauuuguac uccaacagcu gguagcacuu uacugccgcu      780

cuauuggguu acaccuuuac uuaagcgcca auauuuguuu aauuuuaaug aaaagggugu      840

cauuacuagu gcuguugauu gcgccagcag cuacauuagu gaaauaaaau guaagaccca      900

aagucucuua ccgaguacug gugucuauga ucuauccggu uacacggucc aaccuguugg      960

aguuguguac cggcguguuc cuaaccuacc ugauuguaaa auagaggaau ggcucacugc     1020

uaaaucugug ccgucaccuc ucaauuggga gcguaggacu uuccaaaauu guaauuuuaa     1080

uuuaagcagc cugcuacguu auguccaggc ugagucuuug ucguguaaua auauugaugc     1140

guccaaagug uaugguaugu gcuuugguag ugucucaguu gauaaguuug cuaucccccg     1200

aagccgucaa auugauuuac aaauuggcaa cuccggauuu uugcaaacgg cuaauuauaa     1260

gauugauacc gcugccacau caugucagcu guauuacagu cuuccuaaga auaauguuac     1320

cauaaauaac uauaaccccu cgucuuggaa uaggagguau gguuuuaaug augcuggugu     1380

guuuggcaaa aguaaacaug auguugccua cgcccagcaa uguuuuacug ugcgaccuag     1440

cuauuguccg ugugcacaac cggacauagu uagcgcuugc acuagucaga ccaaacccau     1500

gucugcuuau ugccccacag gcacaauuca ucgugagugu ucucuuugga augggcccca     1560

uuugcgcucg gcacguguag guuccggcac guacacgugu gagugcacuu guaaacccaa     1620

uccauuugau acguaugauc uccgcugugg gcaaauuaaa acuauuguua augugggcga     1680

ucauugugaa ggucugggug uuuuagaaga uaaauguggc aauagcgauc cacauaaggg     1740

cuguucuugu gccaaugauu cuuuuaucgg auggucacau gacacuuguu uaguaaauga     1800

ucgcugccaa auuuuugcua acauauuguu aaauggcauu aauaguggga cuacguguuc     1860

cacagauuua caauugccua auacugaagu ggccacuggc guuugcguca gauaugaccu     1920

cuaugguauu acuggucaag guguuuuuaa agaggucaag gcugacuauu auaauagcug     1980

gcaggcccua uuauaugaug uuaaugguaa cuuaaacggg uuccgugacc uuaccacuaa     2040

caagacuuau acgauaagga gcuguuauag uggccguguu ucugcugcau aucauaaaga     2100

agcacccgaa ccggcucugc ucuaucguaa uauaaauugu aguuauguuu uuacuaauaa     2160

uauuucccgu gaggaaaacc cccuuaacua uuuugauagu uauuuggguu guguuguuaa     2220

ugcugauaac cgcacggaug aggcgcuucc uaauugcgau cuccguaugg gugcuggacu     2280

augcguagau uauucaaagu cacgcagagc ccgccgauca guuucuacug gcuaucgauu     2340

aaccacauuc gagccauaca ugccgauguu agucaaugau agcguucaau ccguaggugg     2400

auuauaugag augcaaauac caaccaauuu uacuauuggu caucaugagg aauucaucca     2460

gauaagggcu cccaagguga cuauagauug ugcugcauuu guuuguggug auaacgcugc     2520

augcagacag caguugguug aguauggcuc uuuuugugau aauguuaaug ccauucuuaa     2580

ugagguuaau aaccucuugg auaauaugca auuacaaguu gcuagugcau uaaugcaggg     2640

uguuacuaua aguucgaggc ugccagaugg caucuccggc ccuauagaug acauuaauuu     2700

caguccucua cuuggaugca uagguucaac augugcugaa gacggcaaug gaccuagugc     2760

gauacggggg cguucagcua uagaggauuu auuauuugac aaggucaaac uaucugacgu     2820

uggcuuuguc gaggcuuaua acaauugcac ugguggucaa gaaguucgcg accuccuuug     2880

cguacagucu uuuaauggca ucaaaguauu accucccgug uugucugaga gucaaaucuc     2940

uggcuacaca gcgggugcua cugcggcagc uauguuccca ccuuggacug cagcugcugg     3000

ugugccauuc aguuuaaaug uucaauauag gauuaauggu uuagguguca cuaugaaugu     3060

ucuuagugag aaccaaaaga ugauugcuag ugcuuuuaac aacgcgcucg gugcuauuca     3120

ggaaggguuc gaugcaacca auucugcucu agguaagauc caguccguug uuaaugcaaa     3180

cgcugaagca cuuaauaauu uauuaaacca acuuucuaau agguuuggug cuauuagugc     3240

uucuuuacaa gaaauucuaa cgcggcuuga cgcuguagaa gcaaaggccc agauagaucg     3300

ucuuauuaau ggcagguuaa cugcacuuaa ugcguauaua uccaagcaac ucagugauag     3360

uacgcuuauu aaauuuagug cugcucaggc caucgaaaag gucaaugagu gcguuaagag     3420

ccaaacuacg cgcauuaauu ucuguggcaa ugguaaucac auauuaucac uuguccagaa     3480

ugcgccuuau ggcuuauguu uuauucauuu cagcuacgug ccaacauccu uuaaaacggc     3540

aaaugugagu ccuggacuau gcauuucugg ugauagagga uuggcaccua aagcuggaua     3600

uuuuguucaa gauaauggag aguggaaguu cacaggcagu aauuauuacu acccugaacc     3660

cauuacagau aaaaauagug uugucaugau caguugcgcu gugaauuaca caaaagcgcc     3720

ugaaguuuuc uugaacaacu caauaccaaa ucuacccgac uuuaaggagg aguuagauaa     3780

augguuuaag aaucagacgu cuauugcgcc ugauuuaucc cucgauuucg agaaguuaaa     3840

uguuacuuuc cuggaccuga cuuaugagau gaacaggauu caggaugcaa uuaagaaguu     3900

aaaugagagc uacaucaacc ucaaggaagu uggcacauau gaaauguaug ugaaauggcc     3960

uugguauguu ugguugcuaa uugguuuagc ugguguagcc guuugugugu uauuauucuu     4020

uauauguugc ugcacagguu gcggcucaug uuguuuuaga aaaugcggaa guuguuguga     4080

ugaguaugga ggacaccagg acaguauugu gauacauaau auuucagccc augaggauug     4140

acuaucaca                                                             4149


<210>  21
<211>  1376
<212>  PRT
<213>  Unknown

<220>
<223>  M-CoV Spike (S) Protein

<400>  21

Met Leu Phe Val Phe Ile Leu Leu Leu Pro Ser Cys Leu Gly Tyr Ile 
1               5                   10                  15      


Gly Asp Phe Arg Cys Ile Gln Thr Val Asn Tyr Asn Gly Asn Asn Ala 
            20                  25                  30          


Ser Ala Pro Ser Ile Ser Thr Glu Ala Val Asp Val Ser Lys Gly Leu 
        35                  40                  45              


Gly Thr Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn Ala Thr Leu Leu 
    50                  55                  60                  


Leu Thr Gly Tyr Tyr Pro Val Asp Gly Ser Asn Tyr Arg Asn Leu Ala 
65                  70                  75                  80  


Leu Thr Gly Thr Asn Thr Leu Ser Leu Thr Trp Phe Lys Pro Pro Phe 
                85                  90                  95      


Leu Ser Glu Phe Asn Asp Gly Ile Phe Ala Lys Val Gln Asn Leu Lys 
            100                 105                 110         


Thr Asn Thr Pro Thr Gly Ala Thr Ser Tyr Phe Pro Thr Ile Val Ile 
        115                 120                 125             


Gly Ser Leu Phe Gly Asn Thr Ser Tyr Thr Val Val Leu Glu Pro Tyr 
    130                 135                 140                 


Asn Asn Ile Ile Met Ala Ser Val Cys Thr Tyr Thr Ile Cys Gln Leu 
145                 150                 155                 160 


Pro Tyr Thr Pro Cys Lys Pro Asn Thr Asn Gly Asn Arg Val Ile Gly 
                165                 170                 175     


Phe Trp His Thr Asp Val Lys Pro Pro Ile Cys Leu Leu Lys Arg Asn 
            180                 185                 190         


Phe Thr Phe Asn Val Asn Ala Pro Trp Leu Tyr Phe His Phe Tyr Gln 
        195                 200                 205             


Gln Gly Gly Thr Phe Tyr Ala Tyr Tyr Ala Asp Lys Pro Ser Ala Thr 
    210                 215                 220                 


Thr Phe Leu Phe Ser Val Tyr Ile Gly Asp Ile Leu Thr Gln Tyr Phe 
225                 230                 235                 240 


Val Leu Pro Phe Ile Cys Thr Pro Thr Ala Gly Ser Thr Leu Leu Pro 
                245                 250                 255     


Leu Tyr Trp Val Thr Pro Leu Leu Lys Arg Gln Tyr Leu Phe Asn Phe 
            260                 265                 270         


Asn Glu Lys Gly Val Ile Thr Ser Ala Val Asp Cys Ala Ser Ser Tyr 
        275                 280                 285             


Ile Ser Glu Ile Lys Cys Lys Thr Gln Ser Leu Leu Pro Ser Thr Gly 
    290                 295                 300                 


Val Tyr Asp Leu Ser Gly Tyr Thr Val Gln Pro Val Gly Val Val Tyr 
305                 310                 315                 320 


Arg Arg Val Pro Asn Leu Pro Asp Cys Lys Ile Glu Glu Trp Leu Thr 
                325                 330                 335     


Ala Lys Ser Val Pro Ser Pro Leu Asn Trp Glu Arg Arg Thr Phe Gln 
            340                 345                 350         


Asn Cys Asn Phe Asn Leu Ser Ser Leu Leu Arg Tyr Val Gln Ala Glu 
        355                 360                 365             


Ser Leu Ser Cys Asn Asn Ile Asp Ala Ser Lys Val Tyr Gly Met Cys 
    370                 375                 380                 


Phe Gly Ser Val Ser Val Asp Lys Phe Ala Ile Pro Arg Ser Arg Gln 
385                 390                 395                 400 


Ile Asp Leu Gln Ile Gly Asn Ser Gly Phe Leu Gln Thr Ala Asn Tyr 
                405                 410                 415     


Lys Ile Asp Thr Ala Ala Thr Ser Cys Gln Leu Tyr Tyr Ser Leu Pro 
            420                 425                 430         


Lys Asn Asn Val Thr Ile Asn Asn Tyr Asn Pro Ser Ser Trp Asn Arg 
        435                 440                 445             


Arg Tyr Gly Phe Asn Asp Ala Gly Val Phe Gly Lys Ser Lys His Asp 
    450                 455                 460                 


Val Ala Tyr Ala Gln Gln Cys Phe Thr Val Arg Pro Ser Tyr Cys Pro 
465                 470                 475                 480 


Cys Ala Gln Pro Asp Ile Val Ser Ala Cys Thr Ser Gln Thr Lys Pro 
                485                 490                 495     


Met Ser Ala Tyr Cys Pro Thr Gly Thr Ile His Arg Glu Cys Ser Leu 
            500                 505                 510         


Trp Asn Gly Pro His Leu Arg Ser Ala Arg Val Gly Ser Gly Thr Tyr 
        515                 520                 525             


Thr Cys Glu Cys Thr Cys Lys Pro Asn Pro Phe Asp Thr Tyr Asp Leu 
    530                 535                 540                 


Arg Cys Gly Gln Ile Lys Thr Ile Val Asn Val Gly Asp His Cys Glu 
545                 550                 555                 560 


Gly Leu Gly Val Leu Glu Asp Lys Cys Gly Asn Ser Asp Pro His Lys 
                565                 570                 575     


Gly Cys Ser Cys Ala Asn Asp Ser Phe Ile Gly Trp Ser His Asp Thr 
            580                 585                 590         


Cys Leu Val Asn Asp Arg Cys Gln Ile Phe Ala Asn Ile Leu Leu Asn 
        595                 600                 605             


Gly Ile Asn Ser Gly Thr Thr Cys Ser Thr Asp Leu Gln Leu Pro Asn 
    610                 615                 620                 


Thr Glu Val Ala Thr Gly Val Cys Val Arg Tyr Asp Leu Tyr Gly Ile 
625                 630                 635                 640 


Thr Gly Gln Gly Val Phe Lys Glu Val Lys Ala Asp Tyr Tyr Asn Ser 
                645                 650                 655     


Trp Gln Ala Leu Leu Tyr Asp Val Asn Gly Asn Leu Asn Gly Phe Arg 
            660                 665                 670         


Asp Leu Thr Thr Asn Lys Thr Tyr Thr Ile Arg Ser Cys Tyr Ser Gly 
        675                 680                 685             


Arg Val Ser Ala Ala Tyr His Lys Glu Ala Pro Glu Pro Ala Leu Leu 
    690                 695                 700                 


Tyr Arg Asn Ile Asn Cys Ser Tyr Val Phe Thr Asn Asn Ile Ser Arg 
705                 710                 715                 720 


Glu Glu Asn Pro Leu Asn Tyr Phe Asp Ser Tyr Leu Gly Cys Val Val 
                725                 730                 735     


Asn Ala Asp Asn Arg Thr Asp Glu Ala Leu Pro Asn Cys Asp Leu Arg 
            740                 745                 750         


Met Gly Ala Gly Leu Cys Val Asp Tyr Ser Lys Ser Arg Arg Ala Arg 
        755                 760                 765             


Arg Ser Val Ser Thr Gly Tyr Arg Leu Thr Thr Phe Glu Pro Tyr Met 
    770                 775                 780                 


Pro Met Leu Val Asn Asp Ser Val Gln Ser Val Gly Gly Leu Tyr Glu 
785                 790                 795                 800 


Met Gln Ile Pro Thr Asn Phe Thr Ile Gly His His Glu Glu Phe Ile 
                805                 810                 815     


Gln Ile Arg Ala Pro Lys Val Thr Ile Asp Cys Ala Ala Phe Val Cys 
            820                 825                 830         


Gly Asp Asn Ala Ala Cys Arg Gln Gln Leu Val Glu Tyr Gly Ser Phe 
        835                 840                 845             


Cys Asp Asn Val Asn Ala Ile Leu Asn Glu Val Asn Asn Leu Leu Asp 
    850                 855                 860                 


Asn Met Gln Leu Gln Val Ala Ser Ala Leu Met Gln Gly Val Thr Ile 
865                 870                 875                 880 


Ser Ser Arg Leu Pro Asp Gly Ile Ser Gly Pro Ile Asp Asp Ile Asn 
                885                 890                 895     


Phe Ser Pro Leu Leu Gly Cys Ile Gly Ser Thr Cys Ala Glu Asp Gly 
            900                 905                 910         


Asn Gly Pro Ser Ala Ile Arg Gly Arg Ser Ala Ile Glu Asp Leu Leu 
        915                 920                 925             


Phe Asp Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr Asn 
    930                 935                 940                 


Asn Cys Thr Gly Gly Gln Glu Val Arg Asp Leu Leu Cys Val Gln Ser 
945                 950                 955                 960 


Phe Asn Gly Ile Lys Val Leu Pro Pro Val Leu Ser Glu Ser Gln Ile 
                965                 970                 975     


Ser Gly Tyr Thr Ala Gly Ala Thr Ala Ala Ala Met Phe Pro Pro Trp 
            980                 985                 990         


Thr Ala Ala Ala Gly Val Pro Phe  Ser Leu Asn Val Gln  Tyr Arg Ile 
        995                 1000                 1005             


Asn Gly  Leu Gly Val Thr Met  Asn Val Leu Ser Glu  Asn Gln Lys 
    1010                 1015                 1020             


Met Ile  Ala Ser Ala Phe Asn  Asn Ala Leu Gly Ala  Ile Gln Glu 
    1025                 1030                 1035             


Gly Phe  Asp Ala Thr Asn Ser  Ala Leu Gly Lys Ile  Gln Ser Val 
    1040                 1045                 1050             


Val Asn  Ala Asn Ala Glu Ala  Leu Asn Asn Leu Leu  Asn Gln Leu 
    1055                 1060                 1065             


Ser Asn  Arg Phe Gly Ala Ile  Ser Ala Ser Leu Gln  Glu Ile Leu 
    1070                 1075                 1080             


Thr Arg  Leu Asp Ala Val Glu  Ala Lys Ala Gln Ile  Asp Arg Leu 
    1085                 1090                 1095             


Ile Asn  Gly Arg Leu Thr Ala  Leu Asn Ala Tyr Ile  Ser Lys Gln 
    1100                 1105                 1110             


Leu Ser  Asp Ser Thr Leu Ile  Lys Phe Ser Ala Ala  Gln Ala Ile 
    1115                 1120                 1125             


Glu Lys  Val Asn Glu Cys Val  Lys Ser Gln Thr Thr  Arg Ile Asn 
    1130                 1135                 1140             


Phe Cys  Gly Asn Gly Asn His  Ile Leu Ser Leu Val  Gln Asn Ala 
    1145                 1150                 1155             


Pro Tyr  Gly Leu Cys Phe Ile  His Phe Ser Tyr Val  Pro Thr Ser 
    1160                 1165                 1170             


Phe Lys  Thr Ala Asn Val Ser  Pro Gly Leu Cys Ile  Ser Gly Asp 
    1175                 1180                 1185             


Arg Gly  Leu Ala Pro Lys Ala  Gly Tyr Phe Val Gln  Asp Asn Gly 
    1190                 1195                 1200             


Glu Trp  Lys Phe Thr Gly Ser  Asn Tyr Tyr Tyr Pro  Glu Pro Ile 
    1205                 1210                 1215             


Thr Asp  Lys Asn Ser Val Val  Met Ile Ser Cys Ala  Val Asn Tyr 
    1220                 1225                 1230             


Thr Lys  Ala Pro Glu Val Phe  Leu Asn Asn Ser Ile  Pro Asn Leu 
    1235                 1240                 1245             


Pro Asp  Phe Lys Glu Glu Leu  Asp Lys Trp Phe Lys  Asn Gln Thr 
    1250                 1255                 1260             


Ser Ile  Ala Pro Asp Leu Ser  Leu Asp Phe Glu Lys  Leu Asn Val 
    1265                 1270                 1275             


Thr Phe  Leu Asp Leu Thr Tyr  Glu Met Asn Arg Ile  Gln Asp Ala 
    1280                 1285                 1290             


Ile Lys  Lys Leu Asn Glu Ser  Tyr Ile Asn Leu Lys  Glu Val Gly 
    1295                 1300                 1305             


Thr Tyr  Glu Met Tyr Val Lys  Trp Pro Trp Tyr Val  Trp Leu Leu 
    1310                 1315                 1320             


Ile Gly  Leu Ala Gly Val Ala  Val Cys Val Leu Leu  Phe Phe Ile 
    1325                 1330                 1335             


Cys Cys  Cys Thr Gly Cys Gly  Ser Cys Cys Phe Arg  Lys Cys Gly 
    1340                 1345                 1350             


Ser Cys  Cys Asp Glu Tyr Gly  Gly His Gln Asp Ser  Ile Val Ile 
    1355                 1360                 1365             


His Asn  Ile Ser Ala His Glu  Asp 
    1370                 1375     


<210>  22
<211>  4071
<212>  RNA
<213>  Unknown

<220>
<223>  HKU1-CoV Spike (S) Protein RNA Coding Sequence

<400>  22
auguuauuaa uuauuuuuau uuugccuaca acauuagcug uuauagguga uuuuaauugu       60

acuaauuuug cuauuaauga uuuaaacacc acaguuccuc gcauaaguga guauguugug      120

gauguuucuu augguuuggg uacauauuau auacuugauc guguuuauuu aaauacuacu      180

auauuauuua cugguuauuu cccuaaaucu ggugccaauu uuagggaucu aucuuuaaaa      240

gguacuacau auuugaguac ucuuugguau cagaaacccu uuuuaucuga uuuuaauaau      300

gguauuuuuu cuagaguuaa gaauacuaag uuguauguua auaaaacuuu guauagugag      360

uuuaguacua uaguuauagg uaguguuuuu auuaacaacu cuuauacuau uguuguucaa      420

ccucauaaug guguuuugga gauuacagcu ugucaauaca cuauguguga guauccucau      480

acuauuugua aaucuaaagg uaguucucgu aaugaaucuu ggcauuuuga uaaaucugaa      540

ccuuuguguc uguucaagaa aaauuuuacu uauaauguuu cuacagauug guuguauuuu      600

cauuuuuauc aagaacgugg cacuuuuuau gcuuauuaug cugauucugg caugccuacu      660

acuuuuuuau uuaguuugua ucuugguacu cuuuuaucuc auuauuaugu uuugccuuug      720

acuuguaaug cuauaucuuc uaauacugau aaugagacuu uacaauauug ggucacaccu      780

uugucuaaac gccaauaucu ucuuaaauuu gacaaccgug guguuauuac uaaugcuguu      840

gauuguucua guaguuucuu uagcgagauu caauguaaaa cuaaaucuuu auuaccuaau      900

acugguguuu augacuuauc ugguuuuacu guuaagccug uugcaacugu acaucgucgu      960

auuccugauu uaccugauug ugacauugau aaauggcuua acaauuuuaa uguacccuca     1020

ccucuuaauu gggaacguaa aauuuuuucu aauugcaacu uuaauuugag uacuuugcuu     1080

cguuuaguuc auacugauuc uuuuucuugu aauaauuuug augaaucuaa gauauauggu     1140

aguuguuuua agaguauugu uuuagauaaa uuugccauac ccaacuccag acgaucugau     1200

uugcaguugg gcaguucugg uuuucugcaa ucuucuaauu auaaaauuga cacuacuucu     1260

aguucuuguc aauuguauua uaguuugccu gcaauuaaug uuacuauuaa uaauuauaau     1320

ccuucuucuu ggaauagaag guaugguuuu aauaauuuua auuugagcuc ucauaguguu     1380

guuuacucac guuauuguuu uucuguuaau aauacuuuuu guccuugugc uaaaccuucu     1440

uuugcuucaa guugcaagag ucauaaacca ccuucugcuu ccuguccuau ugguacuaau     1500

uaucguucuu gugagaguac uacuguacuc gaccacacug acugguguag guguucuugu     1560

uuaccugauc cuauaacugc uuaugacccu aggucuuguu cucaaaaaaa gucucugguu     1620

gguguuggug aacauugugc aggguucggu guugaugaag aaaagugugg uguauuggau     1680

ggaucauaua auguuucuug ucuuuguagu acugaugccu uucuagguug gucuuaugac     1740

acuugcguca guaacaaccg uuguaauauu uuuucuaauu uuauuuuaaa ugguaucaau     1800

agugguacca cuuguucuaa ugauuuauug cagccuaaua cugaaguuuu uacugauguu     1860

uguguugauu acgaccuuua ugguauuaca ggacaaggua uuuuuaaaga aguuucugcu     1920

guuuauuaua auaguuggca aaaucuuuug uaugauucua auggcaacau uauugguuuu     1980

aaagauuuug uuacuaauaa aacauauaau auuuucccuu guuaugcagg aagaguuucu     2040

gcugcuuuuc aucaaaaugc uuccucuuug gcuuuacuuu aucguaauuu aaaauguagc     2100

uauguuuuga auaauauuuc uuuaacuacu cagccauauu uugauaguua ucuugguugc     2160

guuuuuaaug cugauaauuu aacugauuau ucuguuucuu cuugugcucu ucgcaugggu     2220

agugguuuuu guguugauua uaacucaccu ucuucuuccu cuucgcgucg uaaacguaga     2280

aguauuucug cuucuuaucg uuuuguuacu uuugaacccu uuaaugucag uuuuguuaau     2340

gacaguauug agucuguggg uggucuuuau gagaucaaaa uucccacuaa cuuuacuaua     2400

guuggucaag aggaauuuau ucaaacuaau ucuccuaaag uuacuauuga uuguucuuua     2460

uuugucuguu cuaauuaugc agcuugccau gacuuauugu cagaguaugg cacuuuuugu     2520

gauaauauua auaguauuuu agaugaaguu aaugguuuac uugauacuac ucaauugcau     2580

guagcugaua cucuuaugca aggugucaca cuuagcucca aucuuaauac uaauuugcau     2640

uuugauguug auaauauuaa uuuuaaaucc cuaguuggau guuuaggucc acacugcggu     2700

ucuucuucuc guucuuuuuu ugaagauuua uuguuugaca aaguuaaacu uucagauguu     2760

gguuuuguug aagcuuauaa caauuguacu ggugguagug aaauuagaga ucuucuuugu     2820

guacaauccu uuaaugguau uaaaguuuug ccuccuauuu ugucugaauc ucaaauuucu     2880

gguuacacca cagccgcuac uguugcugcu auguuuccac cauggucagc agcagcuggc     2940

auaccauuuu cucuuaaugu acaauauaga auuaaugguu uggguguuac uauggauguu     3000

cuuaauaaaa aucaaaaguu gauagcuacu gcuuuuaaua augcucuucu uucuauucag     3060

aaugguuuua gugcuaccaa cucugcacuu gcuaaaauac aaaguguugu uaauucuaau     3120

gcucaagcac uuaauaguuu guuacagcaa uuauuuaaua aauuuggugc aauuaguucu     3180

ucuuuacaag aaauuuuauc ucgucucgau gcuuuagagg cucagguuca gauugauagg     3240

cuuauuaaug gucguuuaac ugcuuuaaau gcuuaugucu cucaacagcu uagugauauu     3300

ucucuuguaa aauuuggugc ugcuuuagcu auggagaagg uuaaugagug uguuaaaagu     3360

caaucuccuc guauuaauuu uugugguaau gguaaucaua uuuugucauu aguucaaaau     3420

gcuccuuaug guuuguuguu uaugcauuuu aguuauaaac cuauuucuuu uaaaacuguu     3480

uuaguaaguc cugguuugug uauaucaggu gauguaggua uugcaccuaa acaaggguau     3540

uuuauuaaac auaaugauca uuggauguuc acugguaguu cuuacuauua uccugaacca     3600

auuucagaua aaaauguugu uuuuaugaau acuuguucug uuaauuuuac uaaagcgccu     3660

cuuguuuauu ugaaucauuc uguaccaaaa uugucugauu uugaaucuga guuaucucau     3720

ugguuuaaaa aucaaacauc cauugcgccu aauuugacuu uaaaucuuca uacuauuaau     3780

gcuacuuuuu uagauuugua uuaugagaug aaucuuauuc aagagucuau uaagucuuug     3840

aauaauaguu auaucaaucu uaaagauaua gguacauaug aaauguaugu aaaauggccu     3900

ugguauguuu ggcuacuaau uucuuuuuca uuuauaauau uccuuguauu gcucuuuuuu     3960

auauguuguu guacugguug ugguucugca uguuuuagua aaugucauaa uuguugugau     4020

gaguauggug gucaucauga uuuuguuauc aaaacaucuc augaugauua g              4071


<210>  23
<211>  1356
<212>  PRT
<213>  Unknown

<220>
<223>  HKU1-CoV Spike (S) Protein

<400>  23

Met Leu Leu Ile Ile Phe Ile Leu Pro Thr Thr Leu Ala Val Ile Gly 
1               5                   10                  15      


Asp Phe Asn Cys Thr Asn Phe Ala Ile Asn Asp Leu Asn Thr Thr Val 
            20                  25                  30          


Pro Arg Ile Ser Glu Tyr Val Val Asp Val Ser Tyr Gly Leu Gly Thr 
        35                  40                  45              


Tyr Tyr Ile Leu Asp Arg Val Tyr Leu Asn Thr Thr Ile Leu Phe Thr 
    50                  55                  60                  


Gly Tyr Phe Pro Lys Ser Gly Ala Asn Phe Arg Asp Leu Ser Leu Lys 
65                  70                  75                  80  


Gly Thr Thr Tyr Leu Ser Thr Leu Trp Tyr Gln Lys Pro Phe Leu Ser 
                85                  90                  95      


Asp Phe Asn Asn Gly Ile Phe Ser Arg Val Lys Asn Thr Lys Leu Tyr 
            100                 105                 110         


Val Asn Lys Thr Leu Tyr Ser Glu Phe Ser Thr Ile Val Ile Gly Ser 
        115                 120                 125             


Val Phe Ile Asn Asn Ser Tyr Thr Ile Val Val Gln Pro His Asn Gly 
    130                 135                 140                 


Val Leu Glu Ile Thr Ala Cys Gln Tyr Thr Met Cys Glu Tyr Pro His 
145                 150                 155                 160 


Thr Ile Cys Lys Ser Lys Gly Ser Ser Arg Asn Glu Ser Trp His Phe 
                165                 170                 175     


Asp Lys Ser Glu Pro Leu Cys Leu Phe Lys Lys Asn Phe Thr Tyr Asn 
            180                 185                 190         


Val Ser Thr Asp Trp Leu Tyr Phe His Phe Tyr Gln Glu Arg Gly Thr 
        195                 200                 205             


Phe Tyr Ala Tyr Tyr Ala Asp Ser Gly Met Pro Thr Thr Phe Leu Phe 
    210                 215                 220                 


Ser Leu Tyr Leu Gly Thr Leu Leu Ser His Tyr Tyr Val Leu Pro Leu 
225                 230                 235                 240 


Thr Cys Asn Ala Ile Ser Ser Asn Thr Asp Asn Glu Thr Leu Gln Tyr 
                245                 250                 255     


Trp Val Thr Pro Leu Ser Lys Arg Gln Tyr Leu Leu Lys Phe Asp Asn 
            260                 265                 270         


Arg Gly Val Ile Thr Asn Ala Val Asp Cys Ser Ser Ser Phe Phe Ser 
        275                 280                 285             


Glu Ile Gln Cys Lys Thr Lys Ser Leu Leu Pro Asn Thr Gly Val Tyr 
    290                 295                 300                 


Asp Leu Ser Gly Phe Thr Val Lys Pro Val Ala Thr Val His Arg Arg 
305                 310                 315                 320 


Ile Pro Asp Leu Pro Asp Cys Asp Ile Asp Lys Trp Leu Asn Asn Phe 
                325                 330                 335     


Asn Val Pro Ser Pro Leu Asn Trp Glu Arg Lys Ile Phe Ser Asn Cys 
            340                 345                 350         


Asn Phe Asn Leu Ser Thr Leu Leu Arg Leu Val His Thr Asp Ser Phe 
        355                 360                 365             


Ser Cys Asn Asn Phe Asp Glu Ser Lys Ile Tyr Gly Ser Cys Phe Lys 
    370                 375                 380                 


Ser Ile Val Leu Asp Lys Phe Ala Ile Pro Asn Ser Arg Arg Ser Asp 
385                 390                 395                 400 


Leu Gln Leu Gly Ser Ser Gly Phe Leu Gln Ser Ser Asn Tyr Lys Ile 
                405                 410                 415     


Asp Thr Thr Ser Ser Ser Cys Gln Leu Tyr Tyr Ser Leu Pro Ala Ile 
            420                 425                 430         


Asn Val Thr Ile Asn Asn Tyr Asn Pro Ser Ser Trp Asn Arg Arg Tyr 
        435                 440                 445             


Gly Phe Asn Asn Phe Asn Leu Ser Ser His Ser Val Val Tyr Ser Arg 
    450                 455                 460                 


Tyr Cys Phe Ser Val Asn Asn Thr Phe Cys Pro Cys Ala Lys Pro Ser 
465                 470                 475                 480 


Phe Ala Ser Ser Cys Lys Ser His Lys Pro Pro Ser Ala Ser Cys Pro 
                485                 490                 495     


Ile Gly Thr Asn Tyr Arg Ser Cys Glu Ser Thr Thr Val Leu Asp His 
            500                 505                 510         


Thr Asp Trp Cys Arg Cys Ser Cys Leu Pro Asp Pro Ile Thr Ala Tyr 
        515                 520                 525             


Asp Pro Arg Ser Cys Ser Gln Lys Lys Ser Leu Val Gly Val Gly Glu 
    530                 535                 540                 


His Cys Ala Gly Phe Gly Val Asp Glu Glu Lys Cys Gly Val Leu Asp 
545                 550                 555                 560 


Gly Ser Tyr Asn Val Ser Cys Leu Cys Ser Thr Asp Ala Phe Leu Gly 
                565                 570                 575     


Trp Ser Tyr Asp Thr Cys Val Ser Asn Asn Arg Cys Asn Ile Phe Ser 
            580                 585                 590         


Asn Phe Ile Leu Asn Gly Ile Asn Ser Gly Thr Thr Cys Ser Asn Asp 
        595                 600                 605             


Leu Leu Gln Pro Asn Thr Glu Val Phe Thr Asp Val Cys Val Asp Tyr 
    610                 615                 620                 


Asp Leu Tyr Gly Ile Thr Gly Gln Gly Ile Phe Lys Glu Val Ser Ala 
625                 630                 635                 640 


Val Tyr Tyr Asn Ser Trp Gln Asn Leu Leu Tyr Asp Ser Asn Gly Asn 
                645                 650                 655     


Ile Ile Gly Phe Lys Asp Phe Val Thr Asn Lys Thr Tyr Asn Ile Phe 
            660                 665                 670         


Pro Cys Tyr Ala Gly Arg Val Ser Ala Ala Phe His Gln Asn Ala Ser 
        675                 680                 685             


Ser Leu Ala Leu Leu Tyr Arg Asn Leu Lys Cys Ser Tyr Val Leu Asn 
    690                 695                 700                 


Asn Ile Ser Leu Thr Thr Gln Pro Tyr Phe Asp Ser Tyr Leu Gly Cys 
705                 710                 715                 720 


Val Phe Asn Ala Asp Asn Leu Thr Asp Tyr Ser Val Ser Ser Cys Ala 
                725                 730                 735     


Leu Arg Met Gly Ser Gly Phe Cys Val Asp Tyr Asn Ser Pro Ser Ser 
            740                 745                 750         


Ser Ser Ser Arg Arg Lys Arg Arg Ser Ile Ser Ala Ser Tyr Arg Phe 
        755                 760                 765             


Val Thr Phe Glu Pro Phe Asn Val Ser Phe Val Asn Asp Ser Ile Glu 
    770                 775                 780                 


Ser Val Gly Gly Leu Tyr Glu Ile Lys Ile Pro Thr Asn Phe Thr Ile 
785                 790                 795                 800 


Val Gly Gln Glu Glu Phe Ile Gln Thr Asn Ser Pro Lys Val Thr Ile 
                805                 810                 815     


Asp Cys Ser Leu Phe Val Cys Ser Asn Tyr Ala Ala Cys His Asp Leu 
            820                 825                 830         


Leu Ser Glu Tyr Gly Thr Phe Cys Asp Asn Ile Asn Ser Ile Leu Asp 
        835                 840                 845             


Glu Val Asn Gly Leu Leu Asp Thr Thr Gln Leu His Val Ala Asp Thr 
    850                 855                 860                 


Leu Met Gln Gly Val Thr Leu Ser Ser Asn Leu Asn Thr Asn Leu His 
865                 870                 875                 880 


Phe Asp Val Asp Asn Ile Asn Phe Lys Ser Leu Val Gly Cys Leu Gly 
                885                 890                 895     


Pro His Cys Gly Ser Ser Ser Arg Ser Phe Phe Glu Asp Leu Leu Phe 
            900                 905                 910         


Asp Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr Asn Asn 
        915                 920                 925             


Cys Thr Gly Gly Ser Glu Ile Arg Asp Leu Leu Cys Val Gln Ser Phe 
    930                 935                 940                 


Asn Gly Ile Lys Val Leu Pro Pro Ile Leu Ser Glu Ser Gln Ile Ser 
945                 950                 955                 960 


Gly Tyr Thr Thr Ala Ala Thr Val Ala Ala Met Phe Pro Pro Trp Ser 
                965                 970                 975     


Ala Ala Ala Gly Ile Pro Phe Ser Leu Asn Val Gln Tyr Arg Ile Asn 
            980                 985                 990         


Gly Leu Gly Val Thr Met Asp Val  Leu Asn Lys Asn Gln  Lys Leu Ile 
        995                 1000                 1005             


Ala Thr  Ala Phe Asn Asn Ala  Leu Leu Ser Ile Gln  Asn Gly Phe 
    1010                 1015                 1020             


Ser Ala  Thr Asn Ser Ala Leu  Ala Lys Ile Gln Ser  Val Val Asn 
    1025                 1030                 1035             


Ser Asn  Ala Gln Ala Leu Asn  Ser Leu Leu Gln Gln  Leu Phe Asn 
    1040                 1045                 1050             


Lys Phe  Gly Ala Ile Ser Ser  Ser Leu Gln Glu Ile  Leu Ser Arg 
    1055                 1060                 1065             


Leu Asp  Ala Leu Glu Ala Gln  Val Gln Ile Asp Arg  Leu Ile Asn 
    1070                 1075                 1080             


Gly Arg  Leu Thr Ala Leu Asn  Ala Tyr Val Ser Gln  Gln Leu Ser 
    1085                 1090                 1095             


Asp Ile  Ser Leu Val Lys Phe  Gly Ala Ala Leu Ala  Met Glu Lys 
    1100                 1105                 1110             


Val Asn  Glu Cys Val Lys Ser  Gln Ser Pro Arg Ile  Asn Phe Cys 
    1115                 1120                 1125             


Gly Asn  Gly Asn His Ile Leu  Ser Leu Val Gln Asn  Ala Pro Tyr 
    1130                 1135                 1140             


Gly Leu  Leu Phe Met His Phe  Ser Tyr Lys Pro Ile  Ser Phe Lys 
    1145                 1150                 1155             


Thr Val  Leu Val Ser Pro Gly  Leu Cys Ile Ser Gly  Asp Val Gly 
    1160                 1165                 1170             


Ile Ala  Pro Lys Gln Gly Tyr  Phe Ile Lys His Asn  Asp His Trp 
    1175                 1180                 1185             


Met Phe  Thr Gly Ser Ser Tyr  Tyr Tyr Pro Glu Pro  Ile Ser Asp 
    1190                 1195                 1200             


Lys Asn  Val Val Phe Met Asn  Thr Cys Ser Val Asn  Phe Thr Lys 
    1205                 1210                 1215             


Ala Pro  Leu Val Tyr Leu Asn  His Ser Val Pro Lys  Leu Ser Asp 
    1220                 1225                 1230             


Phe Glu  Ser Glu Leu Ser His  Trp Phe Lys Asn Gln  Thr Ser Ile 
    1235                 1240                 1245             


Ala Pro  Asn Leu Thr Leu Asn  Leu His Thr Ile Asn  Ala Thr Phe 
    1250                 1255                 1260             


Leu Asp  Leu Tyr Tyr Glu Met  Asn Leu Ile Gln Glu  Ser Ile Lys 
    1265                 1270                 1275             


Ser Leu  Asn Asn Ser Tyr Ile  Asn Leu Lys Asp Ile  Gly Thr Tyr 
    1280                 1285                 1290             


Glu Met  Tyr Val Lys Trp Pro  Trp Tyr Val Trp Leu  Leu Ile Ser 
    1295                 1300                 1305             


Phe Ser  Phe Ile Ile Phe Leu  Val Leu Leu Phe Phe  Ile Cys Cys 
    1310                 1315                 1320             


Cys Thr  Gly Cys Gly Ser Ala  Cys Phe Ser Lys Cys  His Asn Cys 
    1325                 1330                 1335             


Cys Asp  Glu Tyr Gly Gly His  His Asp Phe Val Ile  Lys Thr Ser 
    1340                 1345                 1350             


His Asp  Asp 
    1355     


<210>  24
<211>  4071
<212>  RNA
<213>  Unknown

<220>
<223>  NL63-CoV Spike (S) Protein

<400>  24
augaaacuuu ucuugauuuu gcuuguuuug cccuuggccu cuugcuuuuu cacauguaau       60

aguaaugcua aucucucuau guuacaauua gguguuccug acaauucuuc aacuauuguc      120

acggguuuau ugccaacuca uuggauuugu gcuaaucaga guacaucugu uuacucagcc      180

aaugguuucu uuuauauuga uguugguaau caccguagug cuuuugcacu ccauacuggu      240

uauuaugaug uuaaucagua uuauauuuau guuacuaaug aaauaggcuu aaaugcuucu      300

guuacucuua agauuuguaa guuugguaua aacacuacuu uugauuuuuu aaguaauucu      360

ucuaguucuu uugacuguau aguuaauuug uuauuuacag aacaguuagg ugcgccuuug      420

ggcauaacua uaucugguga aacugugcgu cugcauuuau auaauguaac ucguacuuuu      480

uaugugccag cagcuuauaa acuuacuaaa cuuaguguua aauguuacuu uaacuauucc      540

uguguuuuua guguugucaa cgccaccguu acugugaaug ucaccacaca uaauggccgu      600

guaguuaacu acacuguuug ugaugauugu aaugguuaua cugauaacau auuuucuguu      660

caacaggaug gccgcauucc uaaugguuuc ccuuuuaaua auugguuuuu gcuaacuaau      720

gguuccacac uaguggacgg ggucucuaga cuuuaucaac cacuccguuu aacuuguuua      780

uggccuguac cuggucuuaa aucuucaacu gguuuuguuu auuuuaaugc cacugguucu      840

gauguuaauu guaacggcua ucaacauaau ucuuuugcug auguuaugcg uuacaaucuu      900

aacuucagug cuaauucugu ggauaaucuc aagaguggug uuauaguuuu uaaaacucua      960

caguacgaug uucuguuuua cuguaguaau uccucuucgg gcguucuaga uaccacaaua     1020

ccuuuuggcc cuuccucuca accuuauuac uguuuuauaa auaguaccau caacaccacu     1080

cauguuagca cuuuuguggg uguccuacca cccacugugc gugagauugu uguugcuaga     1140

acuggucagu uuuauauuaa ugguuuuaag uauuuugauu uggguuuuau cgaagcuguc     1200

aauuuuaaug ucacaacugc uagugccaca gauuuuugga cgguugcauu ugcuacuuuu     1260

guugauguuu ugguuaaugu uagugcaacu aagauucaaa acuuacuuua uugcgauucu     1320

ccauuugaaa aguugcagug ugagcacuug caguuuggau ugcaagaugg uuuuuauucu     1380

gcaaauuuuc uugaugauaa uguuuugccu gagacuuaug uugcacuccc cauuuauuau     1440

caacacacgg acauaaauuu uacugcaacu gcaucuuuug gugguucuug uuauguuugu     1500

aaaccacacc agguuaauau aucucuuaau gguaacacuu cagugugugu uagaacaucu     1560

cauuuuucaa uuagguauau uuauaaccgc guuaagagug guucaccagg ugacucuuca     1620

uggcacauuu auuuaaagag uggcacuugu ccauuuucuu uuucuaaguu aaauaauuuu     1680

caaaaguuua agacuauuug uuucucaacc gucgcagugc cugguaguug uaauuuucca     1740

cuugaagcca ccuggcauua cacuucuuau acuauuguug gugcuuugua uguuacuugg     1800

ucugaaggua auuccauuac ugguguaccu uauccugucu cugguauucg ugaguuuagu     1860

aauuuaguuu uaaauaauug uaccaaauau aauauuuaug auuauguugg uacuggaauu     1920

auacguucuu caaaccaguc acuugcuggu gguauuacau auguuucuaa cucugguaau     1980

uuacuugguu uuaaaaaugu uuccacuggu aacauuuuua uugugacacc auguaaccaa     2040

ccagaccaag uagcuguuua ucaacaaagc auuauuggug ccaugacugc uguuaaugag     2100

ucuagauaug gcuugcaaaa cuuacuacag uuaccuaacu uuuauuaugu uaguaauggu     2160

gguaacaauu gcacuacggc cguuaugacu uauucuaauu uugguauuug ugcugauggu     2220

ucuuuaauuc cuguucgucu gcguaauucu agugauaaug guauuucagc cauaaucacu     2280

gcuaauuuau ccauucccuc uaacuggacu acuucaguuc aaguugagua ccuccaaauu     2340

acuaguacuc caauaguugu ugauugugcu acuuaugugu guaaugguaa cccucgcugu     2400

aagaaucuac uuaagcagua uacuucugcu uguaaaacua uugaagaugc cuuacgacuu     2460

agugcucauu uggaaacuaa ugauguuagu aguaugcuaa cuuucgauag caaugcuuuu     2520

aguuuggcua auguuacuag uuuuggagau uauaaccuuu cuaguguuuu accucagaga     2580

aacauucauu caagccguau agcaggacgu agugcuuugg aagauuuguu guuuagcaaa     2640

guuguuacau cugguuuggg uacuguugau guugacuaua agucuuguac uaaaggucuu     2700

ucuauugcug accuugcuug ugcucaguac uacaauggca uaaugguuuu gccagguguu     2760

gcugaugcug aacguauggc cauguauaca gguucucuua uagguggcau ggugcucgga     2820

ggucuuacau cagcagccgc cauaccuuuu ucuuuggcac ugcaagcacg acuuaauuau     2880

guugcuuuac aaacugaugu gcuucaagaa aaucagaaaa uuuuggcugc aucauuuaau     2940

aaggcuauua auaacauugu ugcuucuuuu aguagcguua augaugcuau uacacaaacu     3000

gcagaggcua uacauacugu uacuauugca cuuaauaaga uucaggaugu uguuaaucaa     3060

caggguagug cucuuaacca ucucacuuca caauugagac auaauuuuca ggccauuucu     3120

aauucaauuc aagcuauuua ugaccggcuu gauucaauuc aagccgauca acaaguugac     3180

agauuaauua cuggacggcu ugcagcuuug aaugcauuug uuucccaagu uuugaauaaa     3240

uauacugaag uucguaguuc cagacgcuua gcacagcaga agauuaauga augugucaaa     3300

ucacaaucua auagauaugg uuuuuguggc aauggcaccc auaucuuuuc aaucgucaac     3360

ucagcuccag augguuugcu uuuucuucau acuguuuugc ugccaaccga cuacaagaau     3420

guaaaggcgu ggucggguau cuguguugau ggcauuuacg gcuauguucu gcgucaaccu     3480

aacuugguuc uuuauucuga uaaugguguu uuucguguaa cuuccagggu cauguuccaa     3540

ccucguuuac cuguuuuguc ugauuuugug caaauauaua auuguaaugu uacuuuuguu     3600

aacauaucuc gugucgaguu acauacuguc auaccugacu acguugaugu uaauaaaaca     3660

uuacaagagu uugcacaaaa cuuaccaaag uauguuaagc cuaauuuuga cuugacuccu     3720

uuuaauuuaa cauaccuuaa uuugaguucu gaguugaagc aacucgaagc uaaaacugcu     3780

agucuuuucc aaacuacugu ugaauuacaa ggucuuauug aucagauuaa caguacauau     3840

guugauuuga aguugcuuaa uagguuugaa aauuauauua aauggccuug guggguuugg     3900

cucauuauuu cuguuguuuu uguuguauug uugagucuuc uuguguuuug uugucuuucu     3960

acagguuguu gugguuguug caauuguuua acuucaucaa ugcgagguug uugugauugu     4020

gguucaacua aacuuccuua uuacgaauuu gaaaaggucc acguucaaua a              4071


<210>  25
<211>  1356
<212>  PRT
<213>  Unknown

<220>
<223>  NL63-CoV Spike (S) Protein

<400>  25

Met Lys Leu Phe Leu Ile Leu Leu Val Leu Pro Leu Ala Ser Cys Phe 
1               5                   10                  15      


Phe Thr Cys Asn Ser Asn Ala Asn Leu Ser Met Leu Gln Leu Gly Val 
            20                  25                  30          


Pro Asp Asn Ser Ser Thr Ile Val Thr Gly Leu Leu Pro Thr His Trp 
        35                  40                  45              


Ile Cys Ala Asn Gln Ser Thr Ser Val Tyr Ser Ala Asn Gly Phe Phe 
    50                  55                  60                  


Tyr Ile Asp Val Gly Asn His Arg Ser Ala Phe Ala Leu His Thr Gly 
65                  70                  75                  80  


Tyr Tyr Asp Val Asn Gln Tyr Tyr Ile Tyr Val Thr Asn Glu Ile Gly 
                85                  90                  95      


Leu Asn Ala Ser Val Thr Leu Lys Ile Cys Lys Phe Gly Ile Asn Thr 
            100                 105                 110         


Thr Phe Asp Phe Leu Ser Asn Ser Ser Ser Ser Phe Asp Cys Ile Val 
        115                 120                 125             


Asn Leu Leu Phe Thr Glu Gln Leu Gly Ala Pro Leu Gly Ile Thr Ile 
    130                 135                 140                 


Ser Gly Glu Thr Val Arg Leu His Leu Tyr Asn Val Thr Arg Thr Phe 
145                 150                 155                 160 


Tyr Val Pro Ala Ala Tyr Lys Leu Thr Lys Leu Ser Val Lys Cys Tyr 
                165                 170                 175     


Phe Asn Tyr Ser Cys Val Phe Ser Val Val Asn Ala Thr Val Thr Val 
            180                 185                 190         


Asn Val Thr Thr His Asn Gly Arg Val Val Asn Tyr Thr Val Cys Asp 
        195                 200                 205             


Asp Cys Asn Gly Tyr Thr Asp Asn Ile Phe Ser Val Gln Gln Asp Gly 
    210                 215                 220                 


Arg Ile Pro Asn Gly Phe Pro Phe Asn Asn Trp Phe Leu Leu Thr Asn 
225                 230                 235                 240 


Gly Ser Thr Leu Val Asp Gly Val Ser Arg Leu Tyr Gln Pro Leu Arg 
                245                 250                 255     


Leu Thr Cys Leu Trp Pro Val Pro Gly Leu Lys Ser Ser Thr Gly Phe 
            260                 265                 270         


Val Tyr Phe Asn Ala Thr Gly Ser Asp Val Asn Cys Asn Gly Tyr Gln 
        275                 280                 285             


His Asn Ser Phe Ala Asp Val Met Arg Tyr Asn Leu Asn Phe Ser Ala 
    290                 295                 300                 


Asn Ser Val Asp Asn Leu Lys Ser Gly Val Ile Val Phe Lys Thr Leu 
305                 310                 315                 320 


Gln Tyr Asp Val Leu Phe Tyr Cys Ser Asn Ser Ser Ser Gly Val Leu 
                325                 330                 335     


Asp Thr Thr Ile Pro Phe Gly Pro Ser Ser Gln Pro Tyr Tyr Cys Phe 
            340                 345                 350         


Ile Asn Ser Thr Ile Asn Thr Thr His Val Ser Thr Phe Val Gly Val 
        355                 360                 365             


Leu Pro Pro Thr Val Arg Glu Ile Val Val Ala Arg Thr Gly Gln Phe 
    370                 375                 380                 


Tyr Ile Asn Gly Phe Lys Tyr Phe Asp Leu Gly Phe Ile Glu Ala Val 
385                 390                 395                 400 


Asn Phe Asn Val Thr Thr Ala Ser Ala Thr Asp Phe Trp Thr Val Ala 
                405                 410                 415     


Phe Ala Thr Phe Val Asp Val Leu Val Asn Val Ser Ala Thr Lys Ile 
            420                 425                 430         


Gln Asn Leu Leu Tyr Cys Asp Ser Pro Phe Glu Lys Leu Gln Cys Glu 
        435                 440                 445             


His Leu Gln Phe Gly Leu Gln Asp Gly Phe Tyr Ser Ala Asn Phe Leu 
    450                 455                 460                 


Asp Asp Asn Val Leu Pro Glu Thr Tyr Val Ala Leu Pro Ile Tyr Tyr 
465                 470                 475                 480 


Gln His Thr Asp Ile Asn Phe Thr Ala Thr Ala Ser Phe Gly Gly Ser 
                485                 490                 495     


Cys Tyr Val Cys Lys Pro His Gln Val Asn Ile Ser Leu Asn Gly Asn 
            500                 505                 510         


Thr Ser Val Cys Val Arg Thr Ser His Phe Ser Ile Arg Tyr Ile Tyr 
        515                 520                 525             


Asn Arg Val Lys Ser Gly Ser Pro Gly Asp Ser Ser Trp His Ile Tyr 
    530                 535                 540                 


Leu Lys Ser Gly Thr Cys Pro Phe Ser Phe Ser Lys Leu Asn Asn Phe 
545                 550                 555                 560 


Gln Lys Phe Lys Thr Ile Cys Phe Ser Thr Val Ala Val Pro Gly Ser 
                565                 570                 575     


Cys Asn Phe Pro Leu Glu Ala Thr Trp His Tyr Thr Ser Tyr Thr Ile 
            580                 585                 590         


Val Gly Ala Leu Tyr Val Thr Trp Ser Glu Gly Asn Ser Ile Thr Gly 
        595                 600                 605             


Val Pro Tyr Pro Val Ser Gly Ile Arg Glu Phe Ser Asn Leu Val Leu 
    610                 615                 620                 


Asn Asn Cys Thr Lys Tyr Asn Ile Tyr Asp Tyr Val Gly Thr Gly Ile 
625                 630                 635                 640 


Ile Arg Ser Ser Asn Gln Ser Leu Ala Gly Gly Ile Thr Tyr Val Ser 
                645                 650                 655     


Asn Ser Gly Asn Leu Leu Gly Phe Lys Asn Val Ser Thr Gly Asn Ile 
            660                 665                 670         


Phe Ile Val Thr Pro Cys Asn Gln Pro Asp Gln Val Ala Val Tyr Gln 
        675                 680                 685             


Gln Ser Ile Ile Gly Ala Met Thr Ala Val Asn Glu Ser Arg Tyr Gly 
    690                 695                 700                 


Leu Gln Asn Leu Leu Gln Leu Pro Asn Phe Tyr Tyr Val Ser Asn Gly 
705                 710                 715                 720 


Gly Asn Asn Cys Thr Thr Ala Val Met Thr Tyr Ser Asn Phe Gly Ile 
                725                 730                 735     


Cys Ala Asp Gly Ser Leu Ile Pro Val Arg Leu Arg Asn Ser Ser Asp 
            740                 745                 750         


Asn Gly Ile Ser Ala Ile Ile Thr Ala Asn Leu Ser Ile Pro Ser Asn 
        755                 760                 765             


Trp Thr Thr Ser Val Gln Val Glu Tyr Leu Gln Ile Thr Ser Thr Pro 
    770                 775                 780                 


Ile Val Val Asp Cys Ala Thr Tyr Val Cys Asn Gly Asn Pro Arg Cys 
785                 790                 795                 800 


Lys Asn Leu Leu Lys Gln Tyr Thr Ser Ala Cys Lys Thr Ile Glu Asp 
                805                 810                 815     


Ala Leu Arg Leu Ser Ala His Leu Glu Thr Asn Asp Val Ser Ser Met 
            820                 825                 830         


Leu Thr Phe Asp Ser Asn Ala Phe Ser Leu Ala Asn Val Thr Ser Phe 
        835                 840                 845             


Gly Asp Tyr Asn Leu Ser Ser Val Leu Pro Gln Arg Asn Ile His Ser 
    850                 855                 860                 


Ser Arg Ile Ala Gly Arg Ser Ala Leu Glu Asp Leu Leu Phe Ser Lys 
865                 870                 875                 880 


Val Val Thr Ser Gly Leu Gly Thr Val Asp Val Asp Tyr Lys Ser Cys 
                885                 890                 895     


Thr Lys Gly Leu Ser Ile Ala Asp Leu Ala Cys Ala Gln Tyr Tyr Asn 
            900                 905                 910         


Gly Ile Met Val Leu Pro Gly Val Ala Asp Ala Glu Arg Met Ala Met 
        915                 920                 925             


Tyr Thr Gly Ser Leu Ile Gly Gly Met Val Leu Gly Gly Leu Thr Ser 
    930                 935                 940                 


Ala Ala Ala Ile Pro Phe Ser Leu Ala Leu Gln Ala Arg Leu Asn Tyr 
945                 950                 955                 960 


Val Ala Leu Gln Thr Asp Val Leu Gln Glu Asn Gln Lys Ile Leu Ala 
                965                 970                 975     


Ala Ser Phe Asn Lys Ala Ile Asn Asn Ile Val Ala Ser Phe Ser Ser 
            980                 985                 990         


Val Asn Asp Ala Ile Thr Gln Thr  Ala Glu Ala Ile His  Thr Val Thr 
        995                 1000                 1005             


Ile Ala  Leu Asn Lys Ile Gln  Asp Val Val Asn Gln  Gln Gly Ser 
    1010                 1015                 1020             


Ala Leu  Asn His Leu Thr Ser  Gln Leu Arg His Asn  Phe Gln Ala 
    1025                 1030                 1035             


Ile Ser  Asn Ser Ile Gln Ala  Ile Tyr Asp Arg Leu  Asp Ser Ile 
    1040                 1045                 1050             


Gln Ala  Asp Gln Gln Val Asp  Arg Leu Ile Thr Gly  Arg Leu Ala 
    1055                 1060                 1065             


Ala Leu  Asn Ala Phe Val Ser  Gln Val Leu Asn Lys  Tyr Thr Glu 
    1070                 1075                 1080             


Val Arg  Ser Ser Arg Arg Leu  Ala Gln Gln Lys Ile  Asn Glu Cys 
    1085                 1090                 1095             


Val Lys  Ser Gln Ser Asn Arg  Tyr Gly Phe Cys Gly  Asn Gly Thr 
    1100                 1105                 1110             


His Ile  Phe Ser Ile Val Asn  Ser Ala Pro Asp Gly  Leu Leu Phe 
    1115                 1120                 1125             


Leu His  Thr Val Leu Leu Pro  Thr Asp Tyr Lys Asn  Val Lys Ala 
    1130                 1135                 1140             


Trp Ser  Gly Ile Cys Val Asp  Gly Ile Tyr Gly Tyr  Val Leu Arg 
    1145                 1150                 1155             


Gln Pro  Asn Leu Val Leu Tyr  Ser Asp Asn Gly Val  Phe Arg Val 
    1160                 1165                 1170             


Thr Ser  Arg Val Met Phe Gln  Pro Arg Leu Pro Val  Leu Ser Asp 
    1175                 1180                 1185             


Phe Val  Gln Ile Tyr Asn Cys  Asn Val Thr Phe Val  Asn Ile Ser 
    1190                 1195                 1200             


Arg Val  Glu Leu His Thr Val  Ile Pro Asp Tyr Val  Asp Val Asn 
    1205                 1210                 1215             


Lys Thr  Leu Gln Glu Phe Ala  Gln Asn Leu Pro Lys  Tyr Val Lys 
    1220                 1225                 1230             


Pro Asn  Phe Asp Leu Thr Pro  Phe Asn Leu Thr Tyr  Leu Asn Leu 
    1235                 1240                 1245             


Ser Ser  Glu Leu Lys Gln Leu  Glu Ala Lys Thr Ala  Ser Leu Phe 
    1250                 1255                 1260             


Gln Thr  Thr Val Glu Leu Gln  Gly Leu Ile Asp Gln  Ile Asn Ser 
    1265                 1270                 1275             


Thr Tyr  Val Asp Leu Lys Leu  Leu Asn Arg Phe Glu  Asn Tyr Ile 
    1280                 1285                 1290             


Lys Trp  Pro Trp Trp Val Trp  Leu Ile Ile Ser Val  Val Phe Val 
    1295                 1300                 1305             


Val Leu  Leu Ser Leu Leu Val  Phe Cys Cys Leu Ser  Thr Gly Cys 
    1310                 1315                 1320             


Cys Gly  Cys Cys Asn Cys Leu  Thr Ser Ser Met Arg  Gly Cys Cys 
    1325                 1330                 1335             


Asp Cys  Gly Ser Thr Lys Leu  Pro Tyr Tyr Glu Phe  Glu Lys Val 
    1340                 1345                 1350             


His Val  Gln 
    1355     


<210>  26
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Val Gly 
            20                  25                  30  


<210>  27
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210>  28
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  29
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Met Leu Gly Ser Asn Ser Gly Gln Arg Val Val Phe Thr Ile Leu Leu 
1               5                   10                  15      


Leu Leu Val Ala Pro Ala Tyr Ser 
            20                  


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


Ala 
    


<210>  31
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Met Trp Leu Val Ser Leu Ala Ile Val Thr Ala Cys Ala Gly Ala 
1               5                   10                  15  


<210>  32
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys 
1               5                   10                  15  


<210>  33
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
gggauccuac c                                                            11


<210>  34
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  may be U or A

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  may be U or A

<400>  34
uuauuuann                                                                9


