                               SEQUENCE LISTING

<110> 10X GENOMICS, INC.
 
<120> REVERSE TRANSCRIPTASE VARIANTS FOR IMPROVED PERFORMANCE

<130> 131488-0149

<140> PCT/US2022/033199
<141> 2022-06-13

<150> 63/290,329
<151> 2021-12-16

<150> 63/210,143
<151> 2021-06-14

<160> 45    

<170> PatentIn version 3.5

<210> 1
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Met Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Gly Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Ala Gly Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile His Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 2
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Leu Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Gly Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


Val Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile Tyr Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 3
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Val Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Leu Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Lys Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


Val Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile Tyr Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 4
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Val Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Met Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Lys Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


Val Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile Tyr Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 5
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Met Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Lys Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


Val Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile Tyr Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 6
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Leu Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Gly Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Ala Gly Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


Val Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile Tyr Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 7
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Val Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Leu Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Gly Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Ala Gly Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


Val Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile Tyr Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 8
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Val Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Lys Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Pro Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu 
    290                 295                 300                 


Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Ser Gln Pro Leu 
            420                 425                 430         


Val Ile Lys Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Ala 
        435                 440                 445             


Gly Arg Trp Leu Ser Lys Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asn Gly Ser Ser Leu 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Asp Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asn Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Gly Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Ser Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly His Ser Val Glu Ala Arg Gly Asn Arg Met Ala His Gln Ala Ala 
                645                 650                 655     


Arg Arg Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Pro 
            660                 665                 670     


<210> 9
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Val Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Lys Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Pro Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu 
    290                 295                 300                 


Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Ser Gln Pro Leu 
            420                 425                 430         


Val Ile Lys Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Ala 
        435                 440                 445             


Glu Arg Trp Leu Ser Lys Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asn Gly Ser Ser Leu 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Asp Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Gly Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly His Ser Val Glu Ala Arg Gly Asn His Met Ala His Gln Ala Ala 
                645                 650                 655     


Arg Arg Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Pro 
            660                 665                 670     


<210> 10
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Val Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Lys Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Pro Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu 
    290                 295                 300                 


Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Ser Gln Pro Leu 
            420                 425                 430         


Val Ile Lys Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Ala 
        435                 440                 445             


Gly Arg Trp Leu Ser Lys Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Leu 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Gly Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asn Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile Gln Gly Glu Ile Tyr Arg Arg Arg Gly Phe Leu Thr Ser Lys Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Pro 
            660                 665                 670     


<210> 11
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Val Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Lys Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Pro Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu 
    290                 295                 300                 


Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Ser Gln Pro Leu 
            420                 425                 430         


Val Ile Lys Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Ala 
        435                 440                 445             


Glu Arg Trp Leu Ser Lys Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asn Gly Ser Ser Leu 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Asp Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Gly Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly His Ser Val Glu Ala Arg Gly Asn Arg Met Ala His Gln Ala Ala 
                645                 650                 655     


Arg Arg Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Pro 
            660                 665                 670     


<210> 12
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Val Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Lys Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Pro Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Glu Glu Ala Leu Arg Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu 
    290                 295                 300                 


Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Ser Gln Pro Leu 
            420                 425                 430         


Val Ile Lys Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Ala 
        435                 440                 445             


Gly Arg Trp Leu Ser Lys Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asn Gly Ser Ser Leu 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Asp Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asn Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Gly Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Ser Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly His Ser Val Glu Ala Arg Gly Asn Arg Met Ala His Gln Ala Ala 
                645                 650                 655     


Arg Arg Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Pro 
            660                 665                 670     


<210> 13
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Val Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Lys Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Pro Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Glu Glu Ala Leu Arg Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu 
    290                 295                 300                 


Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Ser Gln Pro Leu 
            420                 425                 430         


Val Ile Lys Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Ala 
        435                 440                 445             


Gly Arg Trp Leu Ser Lys Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Leu 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Gly Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asn Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile Gln Gly Glu Ile Tyr Arg Arg Arg Gly Phe Leu Thr Ser Lys Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Pro 
            660                 665                 670     


<210> 14
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Val Gly Leu Ala Val Arg Gln Ala Leu Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Lys Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Pro Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu 
    290                 295                 300                 


Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Ser Gln Pro Leu 
            420                 425                 430         


Val Ile Lys Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Ala 
        435                 440                 445             


Gly Arg Trp Leu Ser Lys Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asn Gly Ser Ser Leu 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Asp Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asn Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Gly Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Ser Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly His Ser Val Glu Ala Arg Gly Asn Arg Met Ala His Gln Ala Ala 
                645                 650                 655     


Arg Arg Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Pro 
            660                 665                 670     


<210> 15
<211> 671
<212> PRT
<213> Murine leukemia virus

<400> 15
Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Leu 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 16
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      5xHis tag

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 16
His His His His His 
1               5   


<210> 17
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 17
tttttttttt                                                              10


<210> 18
<211> 1315
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 18
agagggaaag cagcccgcag ccucccgcuu cgcucucugc uccuccuguu cgacagucag       60

ccgcaucuuc uuuugcgucg ccagccgagc cacaucgcuc agacaccaug gggaagguga      120

aggucggagu caacggauuu ggucguauug ggcgccuggu caccagggcu gcuuuuaacu      180

cugguaaagu ggauauuguu gccaucaaug accccuucau ugaccucaac uacaugguuu      240

acauguucca auaugauucc acccauggca aauuccaugg caccgucaag gcugagaacg      300

ggaagcuugu caucaaugga aaucccauca ccaucuucca ggagcgagau cccuccaaaa      360

ucaagugggg cgaugcuggc gcugaguacg ucguggaguc cacuggcguc uucaccacca      420

uggagaaggc uggggcucau uugcaggggg gagccaaaag ggucaucauc ucugcccccu      480

cugcugaugc ccccauguuc gucaugggug ugaaccauga gaaguaugac aacagccuca      540

agaucaucag caaugccucc ugcaccacca acugcuuagc accccuggcc aaggucaucc      600

augacaacuu ugguaucgug gaaggacuca ugaccacagu ccaugccauc acugccaccc      660

agaagacugu ggauggcccc uccgggaaac uguggcguga uggccgcggg gcucuccaga      720

acaucauccc ugccucuacu ggcgcugcca aggcuguggg caaggucauc ccugagcuga      780

acgggaagcu cacuggcaug gccuuccgug uccccacugc caacguguca gugguggacc      840

ugaccugccg ucuagaaaaa ccugccaaau augaugacau caagaaggug gugaagcagg      900

cgucggaggg cccccucaag ggcauccugg gcuacacuga gcaccaggug gucuccucug      960

acuucaacag cgacacccac uccuccaccu uugacgcugg ggcuggcauu gcccucaacg     1020

accacuuugu caagcucauu uccugguaug acaacgaauu uggcuacagc aacagggugg     1080

uggaccucau ggcccacaug gccuccaagg aguaagaccc cuggaccacc agccccagca     1140

agagcacaag aggaagagag agacccucac ugcuggggag ucccugccac acucaguccc     1200

ccaccacacu gaaucucccc uccucacagu ugccauguag accccuugaa gaggggaggg     1260

gccuagggag ccgcaccuug ucauguacca ucaauaaagu acccugugcu caacc          1315


<210> 19
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
tggttgagca cagggtactt tattgatgg                                         29


<210> 20
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 20
aagcagtggt atcaacgcag agtacatggg                                        30


<210> 21

<400> 21
000


<210> 22
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Leu Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Gly Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Ala Gly Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile His Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 23
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Val Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Leu Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Gly Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Ala Gly Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile His Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 24
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Met Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Gly Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


Val Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile Tyr Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 25
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Met Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Tyr Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Gly Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Ala Gly Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile His Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 26
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Val Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Leu Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Gly Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


Val Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile Tyr Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 27
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Leu Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Gly Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Ala Asp Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile His Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 28
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Leu Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Gly Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Pro Gly Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile His Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 29
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Leu Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Gly Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


Val Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile His Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 30
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Leu Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Gly Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile Tyr Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 31
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Met Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Gly Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile His Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 32
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Met Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Tyr Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Gly Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile His Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 33
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Leu Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Gly Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile His Cys Pro Gly Gly Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 34
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Leu Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Tyr Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Gly Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile His Cys Pro Gly Gly Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 35
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Val Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Leu Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Gly Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile His Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 36
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Leu Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Tyr Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Gly Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile His Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 37
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Leu Ser Gln Lys Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Gly Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp Arg Trp Leu Ser Lys 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp 
                485                 490                 495     


His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg 
            500                 505                 510         


Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys 
        515                 520                 525             


Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu 
    530                 535                 540                 


Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr 
545                 550                 555                 560 


Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr 
                565                 570                 575     


Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys 
            580                 585                 590         


Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu 
        595                 600                 605             


Ser Ile Ile His Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala 
    610                 615                 620                 


Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr 
625                 630                 635                 640 


Glu Thr Pro Asp Thr Ser Thr Leu Leu 
                645                 


<210> 38
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 38
His His His His His His 
1               5       


<210> 39
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Ser Glu Glu Asp Glu Glu Lys Glu Glu Asp Gly 
1               5                   10      


<210> 40
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210> 41
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Asp Asp Asp Asp Lys 
1               5   


<210> 42
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Ile Glu Gly Arg 
1               


<210> 43
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Leu Val Pro Arg Gly Ser 
1               5       


<210> 44
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Leu Glu Val Leu Phe Gln Gly Pro 
1               5               


<210> 45
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 45
aaaaaaaaaa a                                                            11

