                         SEQUENCE LISTING

<110>  Sanofi
       CHIVUKULA, SUDHA
       ALEFANTIS, Tim
 
<120>  MULTIVALENT INFLUENZA VACCINES

<130>  PAT21205-730050-SA9-324PC

<140>  PCT/IB2022/055655
<141>  2022-06-17

<150>  US 63/212,523
<151>  2021-06-21

<150>  US 63/276,243
<151>  2021-11-05

<150>  PCT/US2021/058250
<151>  2021-11-05

<150>  EP21315198.8
<151>  2021-10-13

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3 sub type of Influenza virus hemagglutinin

<400>  1

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Ile Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Arg Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Lys Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Gly Ser Ser 
145                 150                 155                 160 


Ser Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Asn Tyr Thr 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Lys Glu Gln Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
        195                 200                 205             


Phe Leu Tyr Ala Gln Ser Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Ala Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg 
225                 230                 235                 240 


Asp Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Lys Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys His Ser Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Val Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Glu Ser 
                485                 490                 495     


Ile Arg Asn Glu Thr Tyr Asp His Asn Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRT10279

<400>  2
aggtgcaaca tatgcatata a                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H3_WT

<400>  3
agatgcaaca tttgcatttg a                                                 21


<210>  4
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Perth09 N2 antigen

<400>  4

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Val Ser Leu Thr 
1               5                   10                  15      


Ile Ser Thr Ile Cys Phe Phe Met Gln Ile Ala Ile Leu Ile Thr Thr 
            20                  25                  30          


Val Thr Leu His Phe Lys Gln Tyr Glu Phe Asn Ser Pro Pro Asn Asn 
        35                  40                  45              


Gln Val Met Leu Cys Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu 
    50                  55                  60                  


Ile Val Tyr Leu Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys 
65                  70                  75                  80  


Leu Ala Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys Asp Ile Thr Gly 
                85                  90                  95      


Phe Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly 
            100                 105                 110         


Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp Lys 
        115                 120                 125             


Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn Asn Val His 
    130                 135                 140                 


Ser Asn Asn Thr Val Arg Asp Arg Thr Pro Tyr Arg Thr Leu Leu Met 
145                 150                 155                 160 


Asn Glu Leu Gly Val Pro Phe His Leu Gly Thr Lys Gln Val Cys Ile 
                165                 170                 175     


Ala Trp Ser Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val 
            180                 185                 190         


Cys Ile Thr Gly Asp Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asn 
        195                 200                 205             


Gly Arg Leu Val Asp Ser Val Val Ser Trp Ser Lys Glu Ile Leu Arg 
    210                 215                 220                 


Thr Gln Glu Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val 
225                 230                 235                 240 


Met Thr Asp Gly Ser Ala Ser Gly Lys Ala Asp Thr Lys Ile Leu Phe 
                245                 250                 255     


Ile Glu Glu Gly Lys Ile Val His Thr Ser Thr Leu Ser Gly Ser Ala 
            260                 265                 270         


Gln His Val Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg 
        275                 280                 285             


Cys Val Cys Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Ile Val Asp 
    290                 295                 300                 


Ile Asn Ile Lys Asp His Ser Ile Val Ser Ser Tyr Val Cys Ser Gly 
305                 310                 315                 320 


Leu Val Gly Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser His 
                325                 330                 335     


Cys Leu Asp Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly Trp 
            340                 345                 350         


Ala Phe Asp Asp Gly Asn Asp Val Trp Met Gly Arg Thr Ile Ser Glu 
        355                 360                 365             


Lys Ser Arg Leu Gly Tyr Glu Thr Phe Lys Val Ile Glu Gly Trp Ser 
    370                 375                 380                 


Asn Pro Lys Ser Lys Leu Gln Ile Asn Arg Gln Val Ile Val Asp Arg 
385                 390                 395                 400 


Gly Asn Arg Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser 
                405                 410                 415     


Cys Ile Asn Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Glu 
            420                 425                 430         


Glu Thr Glu Val Leu Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly 
        435                 440                 445             


Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp Ile 
    450                 455                 460                 


Asn Leu Met Pro Ile 
465                 


<210>  5
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mich15 N1 antigen

<400>  5

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Thr 
1               5                   10                  15      


Ile Gly Met Ala Asn Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Val Ser His Ser Ile Gln Ile Gly Asn Gln Ser Gln Ile Glu Thr 
        35                  40                  45              


Cys Asn Gln Ser Val Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln 
    50                  55                  60                  


Thr Tyr Val Asn Ile Ser Asn Thr Asn Phe Ala Ala Gly Gln Ser Val 
65                  70                  75                  80  


Val Ser Val Lys Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly 
                85                  90                  95      


Trp Ala Ile Tyr Ser Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly 
            100                 105                 110         


Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser Pro Leu Glu 
        115                 120                 125             


Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His 
    130                 135                 140                 


Ser Asn Gly Thr Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser 
145                 150                 155                 160 


Cys Pro Ile Gly Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser 
                165                 170                 175     


Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr 
            180                 185                 190         


Ile Gly Ile Ser Gly Pro Asp Ser Gly Ala Val Ala Val Leu Lys Tyr 
        195                 200                 205             


Asn Gly Ile Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu 
    210                 215                 220                 


Arg Thr Gln Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr 
225                 230                 235                 240 


Ile Met Thr Asp Gly Pro Ser Asp Gly Gln Ala Ser Tyr Lys Ile Phe 
                245                 250                 255     


Arg Ile Glu Lys Gly Lys Ile Ile Lys Ser Val Glu Met Lys Ala Pro 
            260                 265                 270         


Asn Tyr His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile 
        275                 280                 285             


Thr Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val 
    290                 295                 300                 


Ser Phe Asn Gln Asn Leu Glu Tyr Gln Met Gly Tyr Ile Cys Ser Gly 
305                 310                 315                 320 


Val Phe Gly Asp Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly 
                325                 330                 335     


Pro Val Ser Ser Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys 
            340                 345                 350         


Tyr Gly Asn Gly Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg 
        355                 360                 365             


Lys Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp 
    370                 375                 380                 


Asn Lys Phe Ser Ile Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp 
                405                 410                 415     


Cys Ile Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Glu 
            420                 425                 430         


Glu Asn Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val 
        435                 440                 445             


Asn Ser Asp Thr Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro 
    450                 455                 460                 


Phe Thr Ile Asp Lys 
465                 


<210>  6
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sing16 H3 antigen

<400>  6

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Ile Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Arg Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Lys Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Gly Ser Ser 
145                 150                 155                 160 


Ser Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Asn Tyr Thr 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Lys Glu Gln Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
        195                 200                 205             


Phe Leu Tyr Ala Gln Ser Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Ala Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg 
225                 230                 235                 240 


Asp Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Lys Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys His Ser Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Val Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Glu Ser 
                485                 490                 495     


Ile Arg Asn Glu Thr Tyr Asp His Asn Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  7
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sing16 N2 antigen

<400>  7

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Val Ser Leu Thr 
1               5                   10                  15      


Ile Ser Thr Ile Cys Phe Phe Met Gln Ile Ala Ile Leu Ile Thr Thr 
            20                  25                  30          


Val Thr Leu His Phe Lys Gln Tyr Glu Phe Asn Ser Pro Pro Asn Asn 
        35                  40                  45              


Gln Val Met Leu Cys Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu 
    50                  55                  60                  


Ile Val Tyr Leu Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys 
65                  70                  75                  80  


Pro Ala Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys Gly Ile Thr Gly 
                85                  90                  95      


Phe Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly 
            100                 105                 110         


Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp Lys 
        115                 120                 125             


Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn Asn Val His 
    130                 135                 140                 


Ser Asn Asn Thr Val Arg Asp Arg Thr Pro Tyr Arg Thr Leu Leu Met 
145                 150                 155                 160 


Asn Glu Leu Gly Val Pro Phe His Leu Gly Thr Lys Gln Val Cys Ile 
                165                 170                 175     


Ala Trp Ser Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val 
            180                 185                 190         


Cys Ile Thr Gly Asp Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asn 
        195                 200                 205             


Gly Arg Leu Ile Asp Ser Val Val Ser Trp Ser Lys Asp Ile Leu Arg 
    210                 215                 220                 


Thr Gln Glu Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val 
225                 230                 235                 240 


Met Thr Asp Gly Asn Ala Thr Gly Lys Ala Asp Thr Lys Ile Leu Phe 
                245                 250                 255     


Ile Glu Glu Gly Lys Ile Val His Thr Ser Lys Leu Ser Gly Ser Ala 
            260                 265                 270         


Gln His Val Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg 
        275                 280                 285             


Cys Val Cys Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Ile Val Asp 
    290                 295                 300                 


Ile Asn Ile Lys Asp His Ser Ile Val Ser Ser Tyr Val Cys Ser Gly 
305                 310                 315                 320 


Leu Val Gly Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser His 
                325                 330                 335     


Cys Leu Asn Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly Trp 
            340                 345                 350         


Ala Phe Asp Asp Gly Asn Asp Val Trp Met Gly Arg Thr Ile Asn Glu 
        355                 360                 365             


Thr Ser Arg Leu Gly Tyr Glu Thr Phe Lys Val Val Glu Gly Trp Ser 
    370                 375                 380                 


Asn Pro Lys Ser Lys Leu Gln Ile Asn Arg Gln Val Ile Val Asp Arg 
385                 390                 395                 400 


Gly Asp Arg Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser 
                405                 410                 415     


Cys Ile Asn Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Glu 
            420                 425                 430         


Glu Thr Glu Val Leu Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly 
        435                 440                 445             


Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp Leu 
    450                 455                 460                 


Asn Leu Met His Ile 
465                 


<210>  8
<211>  1701
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HA strain A/California/7/2009 (H1N1) (CA09)

<400>  8
augaaagcua uccuggucgu cuugcuguau acuuucgcca cugccaacgc cgacacccug       60

uguaucgguu accacgcgaa caacuccacc gacacugugg acaccgugcu cgaaaagaac      120

gugaccguga cucauucugu gaaucugcuc gaggacaagc acaacggaaa guugugcaag      180

cugcgcggag uggcaccgcu gcaccuugga aagugcaaca uugccggaug gauccuggga      240

aacccggagu gcgaaagccu gagcaccgcg uccucauggu ccuacaucgu ggaaaccccg      300

uccucugaca acggcaccug uuaccccggc gauuucaucg acuacgaaga acugcgggag      360

cagcuguccu ccguguccuc guuugaacgc uucgagauuu ucccuaagac cuccagcugg      420

ccuaaucacg auagcaacaa gggcgugacg gcagccugcc cgcacgccgg agcaaaguca      480

uucuacaaga aucugauuug gcucgugaag aaagggaacu cauaccccaa gcuguccaag      540

ucguacauca acgacaaggg aaaggaagug cucgugcucu gggggaucca ccacccaucc      600

accuccgccg accagcagag ccuguaccag aacgccgaug cuuacguguu uguggguucc      660

agccgguacu ccaagaaguu caagccugaa aucgcgauca ggccuaaagu ccgggaccgc      720

gagggccgca ugaacuacua cuggacucuc guggagccug gagacaagau caccuucgag      780

gccaccggaa aucucguggu gccacgcuac gcuuucgcca uggaacggaa cgccggaagc      840

ggcaucauca uuagcgauac uccugugcau gacuguaaca ccacgugcca gacacccaag      900

ggcgccauca acaccagccu gccguuucaa aacauccauc ccauuaccau ugggaagugc      960

cccaaauacg ucaaguccac caagcugagg cuggcgaccg gacugcggaa cauuccgagc     1020

auccagucga gaggccuguu cggugccauc gcgggauuca ucgagggcgg cuggacugga     1080

augguggacg guugguacgg guaucaccac caaaacgaac agggaucagg cuacgcggcc     1140

gauuugaagu ccacccagaa cgccauugau gaaaucacca acaaggucaa cuccgugauu     1200

gagaagauga auacucaauu caccgccgug ggcaaagaau ucaaucaccu ggagaagaga     1260

auagagaacc ugaacaagaa ggucgacgac ggguuccucg acaucuggac cuauaacgcc     1320

gaguugcucg ugcugcugga aaacgaacgg acccuggacu aucacgacuc gaacgugaag     1380

aaccuguacg agaaaguccg cucgcaacug aagaacaacg ccaaggaaau cggaaauggu     1440

ugcuucgagu ucuaccauaa gugcgacaac acuugcaugg aguccgugaa gaacggcacu     1500

uacgauuacc ccaaguacuc cgaagaggcu aaacuuaacc gggaagagau cgauggcgug     1560

aagcucgagu ccaccagaau cuaccagauu cucgccaucu acucgacugu ggcaucgagc     1620

cucguccuug ucgugucccu gggggccauu ucauucugga ugugcuccaa cgggucccug     1680

cagugccgga uuugcaucua a                                               1701


<210>  9
<211>  1410
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  A/Michigan/45/2015 (Mich15) neuraminidase

<400>  9
augaacccaa accagaaaau caucacgauu ggcucgauuu gcaugaccau uggaauggcg       60

aaccuuaucc uccaaauugg caacauuauc ucgaucuggg ucagccacuc gauccagauc      120

ggcaaccaau cccagauuga aacuugcaac cagagcguga uuacuuacga aaacaacacg      180

ugggugaacc agacuuacgu caauauuagc aacacuaacu ucgccgcugg gcagagcguc      240

gucagcguga agcucgccgg aaauuccucg cucugccccg uguccggcug ggcgaucuac      300

agcaaggaua acagcguccg gauugguagc aagggcgacg uuuucgugau ccgcgaaccc      360

uucauaucau gcuccccgcu cgaaugucgc acguucuucc ugacccaagg cgcccugcug      420

aacgacaagc acuccaaugg cacuaucaag gaucggagcc cuuaccggac cuugaugucc      480

ugcccuauug gagaagugcc uucaccauau aacucgcgcu uugaaagcgu ggcuugguca      540

gccuccgccu gccaugacgg gauuaacugg cugaccauug gcauaagcgg ccccgauucc      600

ggcgccgugg ccguccugaa guacaacggg aucaucaccg acaccauuaa guccuggcgc      660

aacaacaucc ugaggaccca ggaguccgag ugcgcgugcg ugaacggguc cugcuuuacc      720

aucaugaccg acggaccguc cgacggucaa gccucguaca agaucuuccg gaucgagaaa      780

ggaaagauca ucaagagcgu ggagaugaag gccccgaacu accacuacga ggaauguuca      840

ugcuaucccg acucguccga gauuacuugc gugugccgcg acaauuggca cggauccaac      900

aggccguggg ucagcuucaa ccagaaccuu gaauaccaga ugggauacau uugcagcgga      960

guguucgggg acaacccucg cccgaacgac aagaccggau cgugugggcc cguguccucc     1020

aacggcgcaa acggcgucaa gggauuuucc uucaaauacg ggaacggggu cuggaucgga     1080

cggaccaaga gcauuucaag cagaaaggga uucgagauga uuugggaccc gaacggcugg     1140

acugguaccg auaacaaauu cagcaucaag caggacaucg ugggaauuaa cgaguggucc     1200

gguuacuccg ggagcuucgu gcagcauccc gaacucacug gacuggacug cauucggccg     1260

ugcuuuuggg uggaauugau ccggggcaga ccugaggaga acacgauuug gaccuccggc     1320

uccucgaucu cguucugcgg agugaacucc gacaccgugg gaugguccug gcccgacggu     1380

gcagagcugc ccuucaccau ugauaaguaa                                      1410


<210>  10
<211>  1701
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  A/Singapore.INFIMH160019/2016 (Sing16; H3N2)

<400>  10
augaaaacca uaaucgcgcu cucauacaua cuuugccugg ucuuugccca aaagaucccu       60

ggcaacgaca acucaaccgc gacccuuugc cucggccauc acgccgugcc gaacggcacu      120

aucgucaaga ccaucacaaa cgaccgcauc gaagugacca acgcgacuga gcuagugcag      180

aacuccagca uuggagagau uugcgauucu ccacaccaaa uccuggacgg agagaauugu      240

accuugaucg acgcgcugcu gggggauccg cagugcgacg gauuccagaa caagaaaugg      300

gaccuuuucg uggaacggag caaggcauac ucgaauugcu accccuacga ugugcccgac      360

uacgccucgc ugcgguccuu ggucgcuucc uccgggaccc uggaauucaa aaacgagagc      420

uuuaauugga ccggagugac ccagaauggc accucgagcg ccugcauucg gggcuccucc      480

ucgagcuucu ucagccgccu gaacuggcuc acucaccuca acuacaccua cccggcacug      540

aacgugacca ugccgaacaa ggaacaauuc gacaagcucu acauuugggg ggugcaucac      600

ccggguaccg auaaggacca gaucuuccuc uacgcccaau ccucgggccg gaucaccgug      660

uccacuaagc gcucgcagca ggccgugauc ccgaacauug gaagcagacc ccgcauucgc      720

gacauuccau cgaggaucuc gaucuacugg acgauuguca agccuggcga cauccuccuc      780

auuaacucca ccgggaaccu caucgccccu cgggguuauu ucaagauccg cagcgggaag      840

uccuccauca ugagaagcga ugcccccauu ggaaagugca aguccgagug uaucacaccu      900

aacggaagca uucccaauga caagccauuc cagaacguga acagaauuac cuacggagcu      960

ugcccucgcu acgucaaaca uucgacccuc aaguuggcga cuggaaugcg caacgugccg     1020

gagaagcaaa cccgggggau cuucggggcu aucgcgggau ucaucgaaaa uggaugggaa     1080

ggaauggucg augguuggua cgguuucaga caccagaacu ccgaggggcg gggccaggcc     1140

gcagaccuga aguccacuca ggccgcgauu gaccagauca acggaaagcu caacagacuc     1200

auuggaaaga ccaacgaaaa guuccaccaa aucgaaaagg aauucuccga aguggagggc     1260

cgggugcaag accuggagaa guacguggag gacacuaaga ucgaccuuug gagcuauaac     1320

gcagaacucc uuguggcccu ggaaaaccag cacaccaucg accugaccga uucagagaug     1380

aacaagcucu uugagaaaac uaagaagcaa cuccgggaaa acgcugagga caugggaaau     1440

ggaugcuuua agaucuacca caagugcgac aacgccugca uugaguccau acggaacgaa     1500

acuuacgacc auaacgucua ccgggaugaa gcccugaaca acagauucca gaucaagggc     1560

guggagcuga aguccggcua caaagauugg auccugugga uuuccuucgc gauuucaugc     1620

uucuugcucu gcguggcccu ccugggauuc auaauguggg ccugucagaa gggcaacauu     1680

aggugcaaca uaugcauaua a                                               1701


<210>  11
<211>  1410
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Perth/16/2009 (H3N2) NA

<400>  11
augaacccua accagaagau caucacaauu ggaagcgugu cccugaccau uucgacgauu       60

ugcuucuuca ugcaaaucgc gaucuugauu accaccguca cccugcauuu caagcaauac      120

gaauucaacu ccccgccaaa caaccaaguc augcucugcg agcccaccau caucgaacgc      180

aacaucaccg agaucgugua ccuuaccaac acuaccaucg aaaaggagau uugccccaag      240

uuggccgaau accggaacug gagcaagccc cagugugaca ucacgggauu ugcgccauuc      300

agcaaggaua acucgaucag acuuuccgcc gggggcgaca uuugggucac ucgggagccu      360

uacgugagcu gcgacccgga caagugcuac caauucgcac ucggacaggg uaccacccug      420

aacaacgucc auagcaacaa caccgugcgc gauagaaccc cguaccgcac ccuccucaug      480

aacgaacugg gagugccguu ccacuuggga accaaacaag ucugcauugc augguccucc      540

uccuccugcc acgacggcaa agccuggcuu cacguuugca ucaccggcga cgacaagaau      600

gcgacggccu ccuucauaua caaugguaga cucguggaua gcgugguguc augguccaag      660

gaaauucuca ggacucagga gucagagugc gugugcauca acgggacuug cacugucgug      720

augaccgacg gaucggccuc cggaaaggcc gacacuaaga uccucuucau cgaggaggga      780

aagaucgugc acacuucuac ccugagcggc ucggcucagc augucgaaga gugcucgugc      840

uacccccggu aucccggggu ccgcugcgug ugccgggaca auuggaaagg cucaaaccgc      900

cccaucgugg acauuaacau caaggaccac uccaucguga gcuccuacgu augcagcggg      960

cuggucgggg auaccccgcg gaagaacgau uccucguccu ccucccacug ccuggacccu     1020

aacaacgaag agggaggcca cggagugaag ggaugggcuu uugacgaugg caacgacgug     1080

uggaugggca ggacuauuuc cgaaaagucc cggcugggau acgaaaccuu caaggucauc     1140

gagggcuggu ccaacccgaa gucaaagcuc cagaucaacc gccaggucau cguggauagg     1200

ggcaauagau ccggcuacuc cgggaucuuc agcguggaag ggaaguccug cauuaaccga     1260

ugcuucuacg uggaacucau ucggggucgg aaggaggaaa ccgaagugcu guggacuucg     1320

aacucaaucg ugguguuuug ugggaccucc ggaacuuacg gaacuggguc cuggccugac     1380

ggugccgaca ucaaccuuau gccgaucuaa                                      1410


<210>  12
<211>  1701
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  A/Wisconsin/588/2019

<400>  12
augaaagcca uccuuguugu caugcuguac acauucacca ccgcaaaugc ggauacccug       60

uguaucggcu accacgcaaa uaauuccacc gacaccguug auaccguccu ggaaaagaac      120

gugacaguga cucacagcgu caaucuccuu gaggauaaac auaauggcaa gcugugcaag      180

cugagaggcg uggcuccccu gcaucuggga aagugcaaca ucgcugguug gauccucggg      240

aacccagagu gugagucccu cucaaccgca cggucuuggu cauacaucgu ggagacuagc      300

aauucagaca acggcacaug cuaccccggu gacuucauua acuacgagga gcugagagaa      360

cagcugaguu ccgugucauc cuucgagaga uucgaaaucu uccccaaaac cuccuccugg      420

cccaaucaug acuccgacaa uggagugaca gccgcuuguc cccacgccgg ugccaagagu      480

uucuauaaga accucaucug gcuggugaaa aagggcaagu ccuaucccaa aauuaaccag      540

accuacauua acgauaaggg gaaagaaguc cugguccugu gggggauaca ccaccccccu      600

accaucgccg accagcaguc ucuguaucag aacgccgacg ccuacguguu cguggguacc      660

agccguuaua guaaaaaguu caagccagaa auugccacca gaccuaaggu gcgcgaccag      720

gagggccgca ugaacuacua cuggacccug guggaaccug gcgacaagau uacauucgag      780

gccacuggga accugguggc acccagauac gccuuuacaa uggaacggga ugcugggagc      840

ggaaucauua ucuccgauac cccuguccac gacugcaaua cuaccuguca gaccccagaa      900

ggcgcuauca auaccucucu gccuuuccaa aacgugcacc cuaucacuau cgggaaaugu      960

cccaaguaug ugaaaagcac caaacugcgc cuggcaaccg gucugagaaa ugugcccucc     1020

auccaguccc gcggcuuguu cggugcaauc gcuggcuuua ucgagggugg cuggacugga     1080

auggucgaug gcugguacgg cuaccaucac cagaacgagc agggguccgg guaugcugcc     1140

gaccugaaaa gcacucagaa cgccaucgau aaaaucacua acaaggugaa cuccgugauc     1200

gaaaagauga auacacaguu cacagcaguu ggcaaggagu ucaaccaccu ggaaaaacgg     1260

auagagaacc ugaauaagaa agucgaugau ggcuuucugg acaucuggac uuacaaugcc     1320

gagcugcugg ugcuccugga aaacgagcgg acacuggauu aucacgacuc aaacgugaag     1380

aaccuguaug aaaaggugcg uaaccagcug aaaaacaacg ccaaggaaau cggcaauggc     1440

uguuucgaau uuuaccacaa gugugauaau accuguaugg agagcguuaa gaacgggacu     1500

uacgacuacc caaaauacag cgaggaggcc aagcugaacc gggagaagau cgacggcguc     1560

aaacucgacu ccacuagaau auaccagauu cucgccaucu auagcacagu ggcaucaagu     1620

cucguccugg uggugucacu gggagccauc agcuuuugga ugugcagcaa uggaucccuc     1680

caguguagga ucugcaucua a                                               1701


<210>  13
<211>  1701
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  A/Tasmania/503/2020

<400>  13
augaagacca ucaucgcucu guccuacauc cugugccugg uguuugcuca gaaaaucccc       60

gggaaugaca auuccacugc cacucucugc cugggccauc augccgugcc aaauggaacc      120

auugucaaga cuauaacaaa ugaccgcauc gaagugacca acgcuaccga gcugguucag      180

aacagcagua uuggagaaau cugcgauucc ccacaccaga uacuggaugg cggcaacugc      240

acccugaucg acgcacugcu gggugacccu cagugcgacg gauuucagaa uaaggagugg      300

gaccuuuucg uugagcgcag cagagccaau agcaacugcu acccguacga cgugccggau      360

uacgccaguc uucgaagccu ggucgcaucc agcgggacac uggaguuuaa gaaugagucc      420

uuuaauugga caggcgugaa gcagaacggg acuagcagcg caugcauucg gggcaguagc      480

ucauccuucu uuagccgacu gaacuggcug acccaccuca acuacacaua ccccgcacug      540

aaugugacua ugccaaacaa agaacaguuu gacaaacugu acaucugggg agugcaccau      600

ccuagcacag acaaggacca gaucagccug uuugcccagc ccagcggcag gauuaccgug      660

uccacaaaac ggucacagca agccgugauc ccuaauauug gaucccgccc ccggauaagg      720

gacaucccua gucgcaucag uaucuacugg accaucguga agcccggaga uaucuugcuc      780

aucaauagca cuggcaaccu cauugccccc aggggcuauu uuaagaucag aagcggcaag      840

uccagcauua ugcgcagcga cgcacccauu ggcaagugca aguccgagug caucacuccu      900

aaugggucca ucccaaacga caagccauuc caaaauguca acagaaucac cuacggggcu      960

ugcccccgcu acgugaagca gaguacacug aaacuggcca ccgggaugcg caacgugccc     1020

gagaagcaaa cuagaggcau cuuuggagcu aucgcuggcu ucauugagaa uggcugggag     1080

gguauggugg acggcuggua cggauuccgc caccagaaua gcgaaggcag aggccaggca     1140

gcagacuuga aguccaccca ggccgccauu gaucagauca acggcaaacu gaaucggcuu     1200

auuggaaaaa caaacgagaa guuccaucag auugagaagg aguuuagcga gguggagggc     1260

cgcgugcagg aucuggaaaa guacguugaa gacaccaaga ucgaccugug gucauacaau     1320

gcagagcugc ucguugcccu ggaaaaucag cacacaauug accuuacaga cuccgaaaug     1380

aauaagcucu uugaaaagac caagaagcag cugcgcgaga acgccgagga uauggggaac     1440

gguuguuuua agaucuacca caagugugac aacgccugca uuggguccau ccgaaaugaa     1500

acauacgacc acaacgugua uagagaugag gcccugaaca accgauucca gauuaaggga     1560

gucgagcuga agaguggcua uaaggacugg auccugugga ucucauucgc caugucaugc     1620

uuccuucugu guauugcucu gcucggcuuc aucauguggg cuugccagaa aggcaauauc     1680

cggugcaaca ucugcaucua a                                               1701


<210>  14
<211>  1749
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B/Washington/02/2019

<400>  14
augaaagcaa ucauagugcu gcugauggug gugacuagca augccgaucg gaucugcacc       60

ggcaucacuu ccaguaacag cccucaugug gucaaaaccg ccacacaggg cgaggugaac      120

gugaccggag ugauuccacu gacaacuaca ccaacgaaga gucacuucgc caaccugaag      180

ggcaccgaaa cacgaggcaa gcucugcccc aagugucuga auugcaccga ccuggacguc      240

gcuuugggcc gcccuaaaug uaccggcaaa auaccuuccg ccagaguguc cauccugcac      300

gaggugcgcc ccgugaccuc cggguguuuu cccauaaugc acgaccgcac uaaaauccgc      360

cagcugccca aucuucugag gggguacgaa caugucaggc uguccacuca caacgugauc      420

aacgcagaag acgcccccgg aaggccuuau gagauuggaa ccaguggguc cugcccaaac      480

auuaccaacg gcaacggcuu cuucgccacu auggccuggg ccgugccaaa gaacaagacc      540

gccaccaacc cccugacaau ugaagucccu uacaucugca cagagggaga ggaucagauc      600

accguguggg gguuucacuc ugauaacgaa acucagaugg ccaagcugua cggggauucu      660

aaaccccaga aguucaccag uagcgcuaac ggggugacca cccauuaugu gucucagauc      720

ggagguuucc caaaucagac cgaggacggc ggacugcccc agucuggaag gaucguagug      780

gacuauaugg ugcagaagag uggaaaaacc ggcaccauua ccuaucagcg cggcauacug      840

cugccacaga agguguggug ugcuuccggc agguccaagg uuaucaaagg gucccucccc      900

cugaucggcg aagcagauug ucugcacgag aaguacggcg gacugaauaa gagcaaaccc      960

uacuacaccg gagaacacgc uaaggcaauu gggaauuguc cgaucugggu gaagacgccc     1020

cugaaacugg ccaauggcac aaaauaccgg ccccccgcua agcugcugaa ggaacggggg     1080

uucuucggcg ccauagccgg cuuucuggag ggaggcuggg agggcaugau agccgggugg     1140

cacggcuaca cuucccaugg ggcucacggg guggcugugg ccgccgaccu gaagucuacg     1200

caggaagcua ucaacaaaau cacuaagaac cugaacagcc ugucggaauu ggaggucaag     1260

aaucugcagc ggcugagcgg cgccauggau gagcugcaca augagauccu ggagcuugac     1320

gagaaggucg augaucuucg ggccgauaca auuaguagcc aaauugaguu ggccgugcug     1380

cucagcaacg aaggcauaau caacagcgag gacgagcacc uccuggcucu ggagagaaag     1440

cugaagaaga ugcucggccc uagcgcaguu gagaucggaa acggcugcuu cgaaaccaag     1500

cacaagugca accagaccug ccuggacagg aucgcggcag gaacauucga cgcuggggaa     1560

uucagccucc ccaccuucga cagccugaac aucacagccg ccagucugaa ugaugacgga     1620

cuggauaacc auaccauccu gcuguacuac ucuaccgcug cuuccucccu ggccgugaca     1680

uugaugaucg caaucuuugu gguuuauaug gugagccgag acaacgucag uugcaguauc     1740

ugccuuuaa                                                             1749


<210>  15
<211>  1755
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B/Phuket/3073/2013

<400>  15
augaaagcca ucauugugcu gcugaugguu guuacaagca acgccgaccg caucugcacc       60

gggauuacaa gcagcaauag cccucacgug gugaagacag caacacaggg agaggugaac      120

gugaccggcg ugauuccacu gacaaccacc ccaacuaaau cuuacuuugc aaaccugaaa      180

gggacacgga ccagaggaaa gcugugcccu gauugccuga auugcacaga ccuggacgug      240

gcccugggca gaccaaugug cgugggcacu acaccaagcg ccaaggccuc cauccuccau      300

gaggugcggc ccgugacuuc uggauguuuc cccauuaugc acgacagaac caagauuaga      360

cagcugccaa accugcuccg cggcuacgag aaaauucgcc ugucuacaca gaaugugauc      420

gacgccgaga aggcuccagg aggaccauac agacugggga cuucuggcag cugcccuaac      480

gccaccucua agaucggguu cuucgcaacc auggcuuggg ccgugccuaa agacaauuac      540

aagaaugcca ccaauccacu gacugucgag gugccauaua uuugcacaga gggggaggac      600

cagaucacug uguggggcuu ucauagcgau aauaagacuc agaugaaguc ucucuacggc      660

gacucuaacc cucagaaguu caccuccucu gccaacgggg ugacaacaca cuacgugucc      720

cagaucgggg acuuuccuga ccagaccgag gauggaggac ugccucaguc uggacgcauc      780

gugguggacu auaugaugca gaagccuggg aagaccggca cuaucgugua ccagaggggc      840

gugcugcugc cccaaaaggu guggugugcc uccggaagaa gcaaagugau uaagggaucc      900

cugccucuga uuggggaggc cgauugccug caugaagagu auggagggcu gaacaagucc      960

aagccauacu auacaggaaa gcacgcaaaa gccaucggca acugucccau cugggucaaa     1020

acuccucuga agcuggccaa cggcaccaaa uaccgcccuc cagccaagcu gcugaaagaa     1080

cgcggauucu ucggcgccau ugcaggguuu cuggaaggag gcugggaggg caugauugcu     1140

ggauggcacg gauauaccuc ucacggcgcu cacggggugg ccguggccgc cgaucugaag     1200

uccacacagg aggcaauuaa caagaucacc aagaaucuga auucacuguc cgagcucgaa     1260

gugaaaaacc ugcagcgccu guccggcgcc auggacgagc ugcacaauga aauccuggag     1320

cuggacgaga agguggacga ccugcgggcu gacacuauca gcagccagau cgagcuggca     1380

gugcugcuga gcaaugaggg caucaucaac ucagaagacg aacaccuccu ggcacuggaa     1440

aggaaacuca agaagaugcu gggccccucc gcaguggaca uugggaacgg cuguuucgaa     1500

accaagcaua aguguaacca gacuugucug gauaggaucg cagcaggaac cuucaacgcc     1560

ggcgaauuuu cucugccaac auuugacucc cugaacauca cagcugcauc ccugaacgac     1620

gacggacugg acaaucacac cauccugcug uacuacucua cugccgcuag cucccuggcc     1680

gugacccuga ugcuggccau cuucaucgug uacaugguuu ccagggauaa cgugucuugu     1740

agcauuugcc uguaa                                                      1755


<210>  16

<400>  16
000

<210>  17

<400>  17
000

<210>  18

<400>  18
000

<210>  19
<211>  140
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5UTR

<400>  19
ggacagaucg ccuggagacg ccauccacgc uguuuugacc uccauagaag acaccgggac       60

cgauccagcc uccgcggccg ggaacggugc auuggaacgc ggauuccccg ugccaagagu      120

gacucaccgu ccuugacacg                                                  140


<210>  20
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3UTR sequence

<400>  20
cggguggcau cccugugacc ccuccccagu gccucuccug gcccuggaag uugccacucc       60

agugcccacc agccuugucc uaauaaaauu aaguugcauc                            100


<210>  21

<400>  21
000

<210>  22
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5 UTRs derived from CMV immediate-early 1 (IE1)

<400>  22
gggauccuac c                                                            11


<210>  23
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Poly(A) tail

<400>  23
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa gcauaugacu aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                 110


<210>  24
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA09 H1 antigen

<400>  24

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser 
    210                 215                 220                 


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Arg 
225                 230                 235                 240 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210>  25
<211>  1941
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  H3 sub type of Influenza virus hemagglutinin

<400>  25
ggacagaucg ccuggagacg ccauccacgc uguuuugacc uccauagaag acaccgggac       60

cgauccagcc uccgcggccg ggaacggugc auuggaacgc ggauuccccg ugccaagagu      120

gacucaccgu ccuugacacg augaaaacca uaaucgcgcu cucauacaua cuuugccugg      180

ucuuugccca aaagaucccu ggcaacgaca acucaaccgc gacccuuugc cucggccauc      240

acgccgugcc gaacggcacu aucgucaaga ccaucacaaa cgaccgcauc gaagugacca      300

acgcgacuga gcuagugcag aacuccagca uuggagagau uugcgauucu ccacaccaaa      360

uccuggacgg agagaauugu accuugaucg acgcgcugcu gggggauccg cagugcgacg      420

gauuccagaa caagaaaugg gaccuuuucg uggaacggag caaggcauac ucgaauugcu      480

accccuacga ugugcccgac uacgccucgc ugcgguccuu ggucgcuucc uccgggaccc      540

uggaauucaa aaacgagagc uuuaauugga ccggagugac ccagaauggc accucgagcg      600

ccugcauucg gggcuccucc ucgagcuucu ucagccgccu gaacuggcuc acucaccuca      660

acuacaccua cccggcacug aacgugacca ugccgaacaa ggaacaauuc gacaagcucu      720

acauuugggg ggugcaucac ccggguaccg auaaggacca gaucuuccuc uacgcccaau      780

ccucgggccg gaucaccgug uccacuaagc gcucgcagca ggccgugauc ccgaacauug      840

gaagcagacc ccgcauucgc gacauuccau cgaggaucuc gaucuacugg acgauuguca      900

agccuggcga cauccuccuc auuaacucca ccgggaaccu caucgccccu cgggguuauu      960

ucaagauccg cagcgggaag uccuccauca ugagaagcga ugcccccauu ggaaagugca     1020

aguccgagug uaucacaccu aacggaagca uucccaauga caagccauuc cagaacguga     1080

acagaauuac cuacggagcu ugcccucgcu acgucaaaca uucgacccuc aaguuggcga     1140

cuggaaugcg caacgugccg gagaagcaaa cccgggggau cuucggggcu aucgcgggau     1200

ucaucgaaaa uggaugggaa ggaauggucg augguuggua cgguuucaga caccagaacu     1260

ccgaggggcg gggccaggcc gcagaccuga aguccacuca ggccgcgauu gaccagauca     1320

acggaaagcu caacagacuc auuggaaaga ccaacgaaaa guuccaccaa aucgaaaagg     1380

aauucuccga aguggagggc cgggugcaag accuggagaa guacguggag gacacuaaga     1440

ucgaccuuug gagcuauaac gcagaacucc uuguggcccu ggaaaaccag cacaccaucg     1500

accugaccga uucagagaug aacaagcucu uugagaaaac uaagaagcaa cuccgggaaa     1560

acgcugagga caugggaaau ggaugcuuua agaucuacca caagugcgac aacgccugca     1620

uugaguccau acggaacgaa acuuacgacc auaacgucua ccgggaugaa gcccugaaca     1680

acagauucca gaucaagggc guggagcuga aguccggcua caaagauugg auccugugga     1740

uuuccuucgc gauuucaugc uucuugcucu gcguggcccu ccugggauuc auaauguggg     1800

ccugucagaa gggcaacauu aggugcaaca uaugcauaua acggguggca ucccugugac     1860

cccuccccag ugccucuccu ggcccuggaa guugccacuc cagugcccac cagccuuguc     1920

cuaauaaaau uaaguugcau c                                               1941


