                         SEQUENCE LISTING

<110>  BIORCHESTRA CO., LTD.
 
<120>  USE OF MIRNA-485 INHIBITORS FOR TREATING INFLAMMASOME-RELATED 
       DISEASES OR DISORDERS

<130>  4366.053PC01

<150>  US 63/210,408
<151>  2021-06-14

<160>  128   

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-485-3p

<400>  1
gucauacacg gcucuccucu cu                                                22


<210>  2
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  2
uguauga                                                                  7


<210>  3
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  3
guguauga                                                                 8


<210>  4
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  4
cguguauga                                                                9


<210>  5
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  5
ccguguauga                                                              10


<210>  6
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  6
gccguguaug a                                                            11


<210>  7
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  7
agccguguau ga                                                           12


<210>  8
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  8
gagccgugua uga                                                          13


<210>  9
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  9
agagccgugu auga                                                         14


<210>  10
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  10
gagagccgug uauga                                                        15


<210>  11
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  11
ggagagccgu guauga                                                       16


<210>  12
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  12
aggagagccg uguauga                                                      17


<210>  13
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  13
gaggagagcc guguauga                                                     18


<210>  14
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  14
agaggagagc cguguauga                                                    19


<210>  15
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  15
gagaggagag ccguguauga                                                   20


<210>  16
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  16
uguaugac                                                                 8


<210>  17
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  17
guguaugac                                                                9


<210>  18
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  18
cguguaugac                                                              10


<210>  19
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  19
ccguguauga c                                                            11


<210>  20
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  20
gccguguaug ac                                                           12


<210>  21
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  21
agccguguau gac                                                          13


<210>  22
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  22
gagccgugua ugac                                                         14


<210>  23
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  23
agagccgugu augac                                                        15


<210>  24
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  24
gagagccgug uaugac                                                       16


<210>  25
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  25
ggagagccgu guaugac                                                      17


<210>  26
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  26
aggagagccg uguaugac                                                     18


<210>  27
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  27
gaggagagcc guguaugac                                                    19


<210>  28
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  28
agaggagagc cguguaugac                                                   20


<210>  29
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  29
gagaggagag ccguguauga c                                                 21


<210>  30
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  30
agagaggaga gccguguaug ac                                                22


<210>  31
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SIRT1 Isoform 1

<400>  31

Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser 
1               5                   10                  15      


Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro 
            20                  25                  30          


Leu Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro 
        35                  40                  45              


Gly Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala 
    50                  55                  60                  


Arg Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu 
65                  70                  75                  80  


Ala Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala 
                85                  90                  95      


Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Leu Gln Gly Pro Ser Arg 
            100                 105                 110         


Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu 
        115                 120                 125             


Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg Asp 
    130                 135                 140                 


Asn Leu Leu Phe Gly Asp Glu Ile Ile Thr Asn Gly Phe His Ser Cys 
145                 150                 155                 160 


Glu Ser Asp Glu Glu Asp Arg Ala Ser His Ala Ser Ser Ser Asp Trp 
                165                 170                 175     


Thr Pro Arg Pro Arg Ile Gly Pro Tyr Thr Phe Val Gln Gln His Leu 
            180                 185                 190         


Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu 
        195                 200                 205             


Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val 
    210                 215                 220                 


Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile 
225                 230                 235                 240 


Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile 
                245                 250                 255     


Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp 
            260                 265                 270         


Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro 
        275                 280                 285             


Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys 
    290                 295                 300                 


Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln 
305                 310                 315                 320 


Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu 
                325                 330                 335     


Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln 
            340                 345                 350         


Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr 
        355                 360                 365             


Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg 
    370                 375                 380                 


Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala 
385                 390                 395                 400 


Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu 
                405                 410                 415     


Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu 
            420                 425                 430         


Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val 
        435                 440                 445             


Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile 
    450                 455                 460                 


Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly 
465                 470                 475                 480 


Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu 
                485                 490                 495     


Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu 
            500                 505                 510         


Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu Pro 
        515                 520                 525             


Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr 
    530                 535                 540                 


Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala Ala 
545                 550                 555                 560 


Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met Glu 
                565                 570                 575     


Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile Ala 
            580                 585                 590         


Glu Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser Thr Gly 
        595                 600                 605             


Glu Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys Cys Trp 
    610                 615                 620                 


Pro Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp Gly Asn 
625                 630                 635                 640 


Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala Glu 
                645                 650                 655     


Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser Cys Gly 
            660                 665                 670         


Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu Glu Pro 
        675                 680                 685             


Met Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu Glu Asp 
    690                 695                 700                 


Glu Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly Thr Asp 
705                 710                 715                 720 


Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys Gln Glu 
                725                 730                 735     


Val Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser 
            740                 745         


<210>  32
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SIRT1 Isoform 2

<400>  32

Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser 
1               5                   10                  15      


Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro 
            20                  25                  30          


Leu Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro 
        35                  40                  45              


Gly Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala 
    50                  55                  60                  


Arg Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu 
65                  70                  75                  80  


Ala Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala 
                85                  90                  95      


Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Leu Gln Gly Pro Ser Arg 
            100                 105                 110         


Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu 
        115                 120                 125             


Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg Asp 
    130                 135                 140                 


Asn Leu Leu Phe Gly Asp Glu Ile Ile Thr Asn Gly Phe His Ser Cys 
145                 150                 155                 160 


Glu Ser Asp Glu Glu Asp Arg Ala Ser His Ala Ser Ser Ser Asp Trp 
                165                 170                 175     


Thr Pro Arg Pro Arg Ile Gly Pro Tyr Thr Phe Val Gln Gln His Leu 
            180                 185                 190         


Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu 
        195                 200                 205             


Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val 
    210                 215                 220                 


Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile 
225                 230                 235                 240 


Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile 
                245                 250                 255     


Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp 
            260                 265                 270         


Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro 
        275                 280                 285             


Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys 
    290                 295                 300                 


Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln 
305                 310                 315                 320 


Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu 
                325                 330                 335     


Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln 
            340                 345                 350         


Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr 
        355                 360                 365             


Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg 
    370                 375                 380                 


Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala 
385                 390                 395                 400 


Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu 
                405                 410                 415     


Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu 
            420                 425                 430         


Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val 
        435                 440                 445             


Ala Leu Ile Pro Ser Asn Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr 
    450                 455                 460                 


Ile Phe His Gly Ala Glu Val Tyr Ser Asp Ser Glu Asp Asp Val Leu 
465                 470                 475                 480 


Ser Ser Ser Ser Cys Gly Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser 
                485                 490                 495     


Pro Ser Leu Glu Glu Pro Met Glu Asp Glu Ser Glu Ile Glu Glu Phe 
            500                 505                 510         


Tyr Asn Gly Leu Glu Asp Glu Pro Asp Val Pro Glu Arg Ala Gly Gly 
        515                 520                 525             


Ala Gly Phe Gly Thr Asp Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala 
    530                 535                 540                 


Ile Ser Val Lys Gln Glu Val Thr Asp Met Asn Tyr Pro Ser Asn Lys 
545                 550                 555                 560 


Ser 
    


<210>  33
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-485-5p

<400>  33
agaggcuggc cgugaugaau uc                                                22


<210>  34
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-485-3p

<400>  34
agucauacac ggcucuccuc uc                                                22


<210>  35
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-485-5p

<400>  35
agaggcuggc cgugaugaau uc                                                22


<210>  36
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD36 Isoform 1

<400>  36

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Thr Ile Lys 
465                 470         


<210>  37
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD36 Isoform 2

<400>  37

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Glu Thr Cys Val His Phe Thr Ser Ser Phe Ser Val Cys Lys Ser 
        275                 280                 285             


<210>  38
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD36 Isoform 3

<400>  38

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Ser Ile Tyr Ala Val Phe 
225                 230                 235                 240 


Glu Ser Asp Val Asn Leu Lys Gly Ile Pro Val Tyr Arg Phe Val Leu 
                245                 250                 255     


Pro Ser Lys Ala Phe Ala Ser Pro Val Glu Asn Pro Asp Asn Tyr Cys 
            260                 265                 270         


Phe Cys Thr Glu Lys Ile Ile Ser Lys Asn Cys Thr Ser Tyr Gly Val 
        275                 280                 285             


Leu Asp Ile Ser Lys Cys Lys Glu Gly Arg Pro Val Tyr Ile Ser Leu 
    290                 295                 300                 


Pro His Phe Leu Tyr Ala Ser Pro Asp Val Ser Glu Pro Ile Asp Gly 
305                 310                 315                 320 


Leu Asn Pro Asn Glu Glu Glu His Arg Thr Tyr Leu Asp Ile Glu Pro 
                325                 330                 335     


Ile Thr Gly Phe Thr Leu Gln Phe Ala Lys Arg Leu Gln Val Asn Leu 
            340                 345                 350         


Leu Val Lys Pro Ser Glu Lys Ile Gln Val Leu Lys Asn Leu Lys Arg 
        355                 360                 365             


Asn Tyr Ile Val Pro Ile Leu Trp Leu Asn Glu Thr Gly Thr Ile Gly 
    370                 375                 380                 


Asp Glu Lys Ala Asn Met Phe Arg Ser Gln Val Thr Gly Lys Ile Asn 
385                 390                 395                 400 


Leu Leu Gly Leu Ile Glu Met Ile Leu Leu Ser Val Gly Val Val Met 
                405                 410                 415     


Phe Val Ala Phe Met Ile Ser Tyr Cys Ala Cys Arg Ser Lys Thr Ile 
            420                 425                 430         


Lys 
    


<210>  39
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD36 Isoform 4

<400>  39

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Tyr 
    130                 135                 140                 


Asn Asn Thr Ala Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn 
145                 150                 155                 160 


Ile Ser Lys Val Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu 
                165                 170                 175     


Ser Tyr Trp Glu Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala 
            180                 185                 190         


Ser Phe Pro Pro Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser 
        195                 200                 205             


Ser Asp Ile Cys Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn 
    210                 215                 220                 


Leu Lys Gly Ile Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe 
225                 230                 235                 240 


Ala Ser Pro Val Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys 
                245                 250                 255     


Ile Ile Ser Lys Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys 
            260                 265                 270         


Cys Lys Glu Gly Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr 
        275                 280                 285             


Ala Ser Pro Asp Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu 
    290                 295                 300                 


Glu Glu His Arg Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr 
305                 310                 315                 320 


Leu Gln Phe Ala Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser 
                325                 330                 335     


Glu Lys Ile Gln Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro 
            340                 345                 350         


Ile Leu Trp Leu Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn 
        355                 360                 365             


Met Phe Arg Ser Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile 
    370                 375                 380                 


Glu Met Ile Leu Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met 
385                 390                 395                 400 


Ile Ser Tyr Cys Ala Cys Arg Ser Lys Thr Ile Lys 
                405                 410         


<210>  40
<211>  798
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGC1 Isoform 1

<400>  40

Met Ala Trp Asp Met Cys Asn Gln Asp Ser Glu Ser Val Trp Ser Asp 
1               5                   10                  15      


Ile Glu Cys Ala Ala Leu Val Gly Glu Asp Gln Pro Leu Cys Pro Asp 
            20                  25                  30          


Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn Asp Leu Asp Thr 
        35                  40                  45              


Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp Gln Ser Glu Ile 
    50                  55                  60                  


Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile Phe Glu Lys Ile 
65                  70                  75                  80  


Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu Thr Glu Thr Leu 
                85                  90                  95      


Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser Phe Asp Ala Leu 
            100                 105                 110         


Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser Pro Ser Ser Met 
        115                 120                 125             


Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu Pro Ser Leu Leu 
    130                 135                 140                 


Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu Ser Tyr Asn Glu 
145                 150                 155                 160 


Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His Asn His Arg Ile 
                165                 170                 175     


Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser Trp Ser Asn Lys 
            180                 185                 190         


Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg Arg Pro Cys Ser 
        195                 200                 205             


Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro Pro His Thr Lys 
    210                 215                 220                 


Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys Thr Ser Lys Lys 
225                 230                 235                 240 


Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln Ala Lys Pro Thr 
                245                 250                 255     


Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn Asp Pro Lys Gly 
            260                 265                 270         


Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu Ser Val Glu Leu 
        275                 280                 285             


Ser Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr Pro Pro His Lys Ala 
    290                 295                 300                 


Asn Gln Asp Asn Pro Phe Arg Ala Ser Pro Lys Leu Lys Ser Ser Cys 
305                 310                 315                 320 


Lys Thr Val Val Pro Pro Pro Ser Lys Lys Pro Arg Tyr Ser Glu Ser 
                325                 330                 335     


Ser Gly Thr Gln Gly Asn Asn Ser Thr Lys Lys Gly Pro Glu Gln Ser 
            340                 345                 350         


Glu Leu Tyr Ala Gln Leu Ser Lys Ser Ser Val Leu Thr Gly Gly His 
        355                 360                 365             


Glu Glu Arg Lys Thr Lys Arg Pro Ser Leu Arg Leu Phe Gly Asp His 
    370                 375                 380                 


Asp Tyr Cys Gln Ser Ile Asn Ser Lys Thr Glu Ile Leu Ile Asn Ile 
385                 390                 395                 400 


Ser Gln Glu Leu Gln Asp Ser Arg Gln Leu Glu Asn Lys Asp Val Ser 
                405                 410                 415     


Ser Asp Trp Gln Gly Gln Ile Cys Ser Ser Thr Asp Ser Asp Gln Cys 
            420                 425                 430         


Tyr Leu Arg Glu Thr Leu Glu Ala Ser Lys Gln Val Ser Pro Cys Ser 
        435                 440                 445             


Thr Arg Lys Gln Leu Gln Asp Gln Glu Ile Arg Ala Glu Leu Asn Lys 
    450                 455                 460                 


His Phe Gly His Pro Ser Gln Ala Val Phe Asp Asp Glu Ala Asp Lys 
465                 470                 475                 480 


Thr Gly Glu Leu Arg Asp Ser Asp Phe Ser Asn Glu Gln Phe Ser Lys 
                485                 490                 495     


Leu Pro Met Phe Ile Asn Ser Gly Leu Ala Met Asp Gly Leu Phe Asp 
            500                 505                 510         


Asp Ser Glu Asp Glu Ser Asp Lys Leu Ser Tyr Pro Trp Asp Gly Thr 
        515                 520                 525             


Gln Ser Tyr Ser Leu Phe Asn Val Ser Pro Ser Cys Ser Ser Phe Asn 
    530                 535                 540                 


Ser Pro Cys Arg Asp Ser Val Ser Pro Pro Lys Ser Leu Phe Ser Gln 
545                 550                 555                 560 


Arg Pro Gln Arg Met Arg Ser Arg Ser Arg Ser Phe Ser Arg His Arg 
                565                 570                 575     


Ser Cys Ser Arg Ser Pro Tyr Ser Arg Ser Arg Ser Arg Ser Pro Gly 
            580                 585                 590         


Ser Arg Ser Ser Ser Arg Ser Cys Tyr Tyr Tyr Glu Ser Ser His Tyr 
        595                 600                 605             


Arg His Arg Thr His Arg Asn Ser Pro Leu Tyr Val Arg Ser Arg Ser 
    610                 615                 620                 


Arg Ser Pro Tyr Ser Arg Arg Pro Arg Tyr Asp Ser Tyr Glu Glu Tyr 
625                 630                 635                 640 


Gln His Glu Arg Leu Lys Arg Glu Glu Tyr Arg Arg Glu Tyr Glu Lys 
                645                 650                 655     


Arg Glu Ser Glu Arg Ala Lys Gln Arg Glu Arg Gln Arg Gln Lys Ala 
            660                 665                 670         


Ile Glu Glu Arg Arg Val Ile Tyr Val Gly Lys Ile Arg Pro Asp Thr 
        675                 680                 685             


Thr Arg Thr Glu Leu Arg Asp Arg Phe Glu Val Phe Gly Glu Ile Glu 
    690                 695                 700                 


Glu Cys Thr Val Asn Leu Arg Asp Asp Gly Asp Ser Tyr Gly Phe Ile 
705                 710                 715                 720 


Thr Tyr Arg Tyr Thr Cys Asp Ala Phe Ala Ala Leu Glu Asn Gly Tyr 
                725                 730                 735     


Thr Leu Arg Arg Ser Asn Glu Thr Asp Phe Glu Leu Tyr Phe Cys Gly 
            740                 745                 750         


Arg Lys Gln Phe Phe Lys Ser Asn Tyr Ala Asp Leu Asp Ser Asn Ser 
        755                 760                 765             


Asp Asp Phe Asp Pro Ala Ser Thr Lys Ser Lys Tyr Asp Ser Leu Asp 
    770                 775                 780                 


Phe Asp Ser Leu Leu Lys Glu Ala Gln Arg Ser Leu Arg Arg 
785                 790                 795             


<210>  41
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGC1 Isoform 2

<400>  41

Met Ala Trp Asp Met Cys Asn Gln Asp Ser Glu Ser Val Trp Ser Asp 
1               5                   10                  15      


Ile Glu Cys Ala Ala Leu Val Gly Glu Asp Gln Pro Leu Cys Pro Asp 
            20                  25                  30          


Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn Asp Leu Asp Thr 
        35                  40                  45              


Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp Gln Ser Glu Ile 
    50                  55                  60                  


Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile Phe Glu Lys Ile 
65                  70                  75                  80  


Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu Thr Glu Thr Leu 
                85                  90                  95      


Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser Phe Asp Ala Leu 
            100                 105                 110         


Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser Pro Ser Ser Met 
        115                 120                 125             


Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu Pro Ser Leu Leu 
    130                 135                 140                 


Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu Ser Tyr Asn Glu 
145                 150                 155                 160 


Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His Asn His Arg Ile 
                165                 170                 175     


Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser Trp Ser Asn Lys 
            180                 185                 190         


Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg Arg Pro Cys Ser 
        195                 200                 205             


Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro Pro His Thr Lys 
    210                 215                 220                 


Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys Thr Ser Lys Lys 
225                 230                 235                 240 


Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln Ala Lys Pro Thr 
                245                 250                 255     


Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn Leu Phe Leu 
            260                 265                 270     


<210>  42
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGC1 Isoform 3

<400>  42

Met Asp Glu Thr Ser Pro Arg Leu Glu Glu Asp Trp Lys Lys Val Leu 
1               5                   10                  15      


Gln Arg Glu Ala Gly Trp Gln Cys Ala Ala Leu Val Gly Glu Asp Gln 
            20                  25                  30          


Pro Leu Cys Pro Asp Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val 
        35                  40                  45              


Asn Asp Leu Asp Thr Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser 
    50                  55                  60                  


Asp Gln Ser Glu Ile Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn 
65                  70                  75                  80  


Ile Phe Glu Lys Ile Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val 
                85                  90                  95      


Leu Thr Glu Thr Leu Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro 
            100                 105                 110         


Ser Phe Asp Ala Leu Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala 
        115                 120                 125             


Ser Pro Ser Ser Met Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu 
    130                 135                 140                 


Glu Pro Ser Leu Leu Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln 
145                 150                 155                 160 


Leu Ser Tyr Asn Glu Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn 
                165                 170                 175     


His Asn His Arg Ile Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn 
            180                 185                 190         


Ser Trp Ser Asn Lys Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln 
        195                 200                 205             


Arg Arg Pro Cys Ser Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp 
    210                 215                 220                 


Pro Pro His Thr Lys Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys 
225                 230                 235                 240 


Cys Thr Ser Lys Lys Lys Ser His Thr Gln Ser Gln Ser Gln His Leu 
                245                 250                 255     


Gln Ala Lys Pro Thr Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro 
            260                 265                 270         


Asn Asp Pro Lys Gly Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr 
        275                 280                 285             


Leu Ser Val Glu Leu Ser Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr 
    290                 295                 300                 


Pro Pro His Lys Ala Asn Gln Asp Asn Pro Phe Arg Ala Ser Pro Lys 
305                 310                 315                 320 


Leu Lys Ser Ser Cys Lys Thr Val Val Pro Pro Pro Ser Lys Lys Pro 
                325                 330                 335     


Arg Tyr Ser Glu Ser Ser Gly Thr Gln Gly Asn Asn Ser Thr Lys Lys 
            340                 345                 350         


Gly Pro Glu Gln Ser Glu Leu Tyr Ala Gln Leu Ser Lys Ser Ser Val 
        355                 360                 365             


Leu Thr Gly Gly His Glu Glu Arg Lys Thr Lys Arg Pro Ser Leu Arg 
    370                 375                 380                 


Leu Phe Gly Asp His Asp Tyr Cys Gln Ser Ile Asn Ser Lys Thr Glu 
385                 390                 395                 400 


Ile Leu Ile Asn Ile Ser Gln Glu Leu Gln Asp Ser Arg Gln Leu Glu 
                405                 410                 415     


Asn Lys Asp Val Ser Ser Asp Trp Gln Gly Gln Ile Cys Ser Ser Thr 
            420                 425                 430         


Asp Ser Asp Gln Cys Tyr Leu Arg Glu Thr Leu Glu Ala Ser Lys Gln 
        435                 440                 445             


Val Ser Pro Cys Ser Thr Arg Lys Gln Leu Gln Asp Gln Glu Ile Arg 
    450                 455                 460                 


Ala Glu Leu Asn Lys His Phe Gly His Pro Ser Gln Ala Val Phe Asp 
465                 470                 475                 480 


Asp Glu Ala Asp Lys Thr Gly Glu Leu Arg Asp Ser Asp Phe Ser Asn 
                485                 490                 495     


Glu Gln Phe Ser Lys Leu Pro Met Phe Ile Asn Ser Gly Leu Ala Met 
            500                 505                 510         


Asp Gly Leu Phe Asp Asp Ser Glu Asp Glu Ser Asp Lys Leu Ser Tyr 
        515                 520                 525             


Pro Trp Asp Gly Thr Gln Ser Tyr Ser Leu Phe Asn Val Ser Pro Ser 
    530                 535                 540                 


Cys Ser Ser Phe Asn Ser Pro Cys Arg Asp Ser Val Ser Pro Pro Lys 
545                 550                 555                 560 


Ser Leu Phe Ser Gln Arg Pro Gln Arg Met Arg Ser Arg Ser Arg Ser 
                565                 570                 575     


Phe Ser Arg His Arg Ser Cys Ser Arg Ser Pro Tyr Ser Arg Ser Arg 
            580                 585                 590         


Ser Arg Ser Pro Gly Ser Arg Ser Ser Ser Arg Ser Cys Tyr Tyr Tyr 
        595                 600                 605             


Glu Ser Ser His Tyr Arg His Arg Thr His Arg Asn Ser Pro Leu Tyr 
    610                 615                 620                 


Val Arg Ser Arg Ser Arg Ser Pro Tyr Ser Arg Arg Pro Arg Tyr Asp 
625                 630                 635                 640 


Ser Tyr Glu Glu Tyr Gln His Glu Arg Leu Lys Arg Glu Glu Tyr Arg 
                645                 650                 655     


Arg Glu Tyr Glu Lys Arg Glu Ser Glu Arg Ala Lys Gln Arg Glu Arg 
            660                 665                 670         


Gln Arg Gln Lys Ala Ile Glu Glu Arg Arg Val Ile Tyr Val Gly Lys 
        675                 680                 685             


Ile Arg Pro Asp Thr Thr Arg Thr Glu Leu Arg Asp Arg Phe Glu Val 
    690                 695                 700                 


Phe Gly Glu Ile Glu Glu Cys Thr Val Asn Leu Arg Asp Asp Gly Asp 
705                 710                 715                 720 


Ser Tyr Gly Phe Ile Thr Tyr Arg Tyr Thr Cys Asp Ala Phe Ala Ala 
                725                 730                 735     


Leu Glu Asn Gly Tyr Thr Leu Arg Arg Ser Asn Glu Thr Asp Phe Glu 
            740                 745                 750         


Leu Tyr Phe Cys Gly Arg Lys Gln Phe Phe Lys Ser Asn Tyr Ala Asp 
        755                 760                 765             


Leu Asp Ser Asn Ser Asp Asp Phe Asp Pro Ala Ser Thr Lys Ser Lys 
    770                 775                 780                 


Tyr Asp Ser Leu Asp Phe Asp Ser Leu Leu Lys Glu Ala Gln Arg Ser 
785                 790                 795                 800 


Leu Arg Arg 
            


<210>  43
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGC1 Isoform 4

<400>  43

Met Asp Glu Gly Tyr Phe Cys Ala Ala Leu Val Gly Glu Asp Gln Pro 
1               5                   10                  15      


Leu Cys Pro Asp Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn 
            20                  25                  30          


Asp Leu Asp Thr Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp 
        35                  40                  45              


Gln Ser Glu Ile Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile 
    50                  55                  60                  


Phe Glu Lys Ile Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu 
65                  70                  75                  80  


Thr Glu Thr Leu Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser 
                85                  90                  95      


Phe Asp Ala Leu Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser 
            100                 105                 110         


Pro Ser Ser Met Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu 
        115                 120                 125             


Pro Ser Leu Leu Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu 
    130                 135                 140                 


Ser Tyr Asn Glu Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His 
145                 150                 155                 160 


Asn His Arg Ile Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser 
                165                 170                 175     


Trp Ser Asn Lys Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg 
            180                 185                 190         


Arg Pro Cys Ser Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro 
        195                 200                 205             


Pro His Thr Lys Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys 
    210                 215                 220                 


Thr Ser Lys Lys Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln 
225                 230                 235                 240 


Ala Lys Pro Thr Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn 
                245                 250                 255     


Asp Pro Lys Gly Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu 
            260                 265                 270         


Ser Val Glu Leu Ser Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr Pro 
        275                 280                 285             


Pro His Lys Ala Asn Gln Asp Asn Pro Phe Arg Ala Ser Pro Lys Leu 
    290                 295                 300                 


Lys Ser Ser Cys Lys Thr Val Val Pro Pro Pro Ser Lys Lys Pro Arg 
305                 310                 315                 320 


Tyr Ser Glu Ser Ser Gly Thr Gln Gly Asn Asn Ser Thr Lys Lys Gly 
                325                 330                 335     


Pro Glu Gln Ser Glu Leu Tyr Ala Gln Leu Ser Lys Ser Ser Val Leu 
            340                 345                 350         


Thr Gly Gly His Glu Glu Arg Lys Thr Lys Arg Pro Ser Leu Arg Leu 
        355                 360                 365             


Phe Gly Asp His Asp Tyr Cys Gln Ser Ile Asn Ser Lys Thr Glu Ile 
    370                 375                 380                 


Leu Ile Asn Ile Ser Gln Glu Leu Gln Asp Ser Arg Gln Leu Glu Asn 
385                 390                 395                 400 


Lys Asp Val Ser Ser Asp Trp Gln Gly Gln Ile Cys Ser Ser Thr Asp 
                405                 410                 415     


Ser Asp Gln Cys Tyr Leu Arg Glu Thr Leu Glu Ala Ser Lys Gln Val 
            420                 425                 430         


Ser Pro Cys Ser Thr Arg Lys Gln Leu Gln Asp Gln Glu Ile Arg Ala 
        435                 440                 445             


Glu Leu Asn Lys His Phe Gly His Pro Ser Gln Ala Val Phe Asp Asp 
    450                 455                 460                 


Glu Ala Asp Lys Thr Gly Glu Leu Arg Asp Ser Asp Phe Ser Asn Glu 
465                 470                 475                 480 


Gln Phe Ser Lys Leu Pro Met Phe Ile Asn Ser Gly Leu Ala Met Asp 
                485                 490                 495     


Gly Leu Phe Asp Asp Ser Glu Asp Glu Ser Asp Lys Leu Ser Tyr Pro 
            500                 505                 510         


Trp Asp Gly Thr Gln Ser Tyr Ser Leu Phe Asn Val Ser Pro Ser Cys 
        515                 520                 525             


Ser Ser Phe Asn Ser Pro Cys Arg Asp Ser Val Ser Pro Pro Lys Ser 
    530                 535                 540                 


Leu Phe Ser Gln Arg Pro Gln Arg Met Arg Ser Arg Ser Arg Ser Phe 
545                 550                 555                 560 


Ser Arg His Arg Ser Cys Ser Arg Ser Pro Tyr Ser Arg Ser Arg Ser 
                565                 570                 575     


Arg Ser Pro Gly Ser Arg Ser Ser Ser Arg Ser Cys Tyr Tyr Tyr Glu 
            580                 585                 590         


Ser Ser His Tyr Arg His Arg Thr His Arg Asn Ser Pro Leu Tyr Val 
        595                 600                 605             


Arg Ser Arg Ser Arg Ser Pro Tyr Ser Arg Arg Pro Arg Tyr Asp Ser 
    610                 615                 620                 


Tyr Glu Glu Tyr Gln His Glu Arg Leu Lys Arg Glu Glu Tyr Arg Arg 
625                 630                 635                 640 


Glu Tyr Glu Lys Arg Glu Ser Glu Arg Ala Lys Gln Arg Glu Arg Gln 
                645                 650                 655     


Arg Gln Lys Ala Ile Glu Glu Arg Arg Val Ile Tyr Val Gly Lys Ile 
            660                 665                 670         


Arg Pro Asp Thr Thr Arg Thr Glu Leu Arg Asp Arg Phe Glu Val Phe 
        675                 680                 685             


Gly Glu Ile Glu Glu Cys Thr Val Asn Leu Arg Asp Asp Gly Asp Ser 
    690                 695                 700                 


Tyr Gly Phe Ile Thr Tyr Arg Tyr Thr Cys Asp Ala Phe Ala Ala Leu 
705                 710                 715                 720 


Glu Asn Gly Tyr Thr Leu Arg Arg Ser Asn Glu Thr Asp Phe Glu Leu 
                725                 730                 735     


Tyr Phe Cys Gly Arg Lys Gln Phe Phe Lys Ser Asn Tyr Ala Asp Leu 
            740                 745                 750         


Asp Ser Asn Ser Asp Asp Phe Asp Pro Ala Ser Thr Lys Ser Lys Tyr 
        755                 760                 765             


Asp Ser Leu Asp Phe Asp Ser Leu Leu Lys Glu Ala Gln Arg Ser Leu 
    770                 775                 780                 


Arg Arg 
785     


<210>  44
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGC1 Isoform 5

<400>  44

Met Asp Glu Gly Tyr Phe Cys Ala Ala Leu Val Gly Glu Asp Gln Pro 
1               5                   10                  15      


Leu Cys Pro Asp Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn 
            20                  25                  30          


Asp Leu Asp Thr Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp 
        35                  40                  45              


Gln Ser Glu Ile Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile 
    50                  55                  60                  


Phe Glu Lys Ile Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu 
65                  70                  75                  80  


Thr Glu Thr Leu Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser 
                85                  90                  95      


Phe Asp Ala Leu Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser 
            100                 105                 110         


Pro Ser Ser Met Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu 
        115                 120                 125             


Pro Ser Leu Leu Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu 
    130                 135                 140                 


Ser Tyr Asn Glu Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His 
145                 150                 155                 160 


Asn His Arg Ile Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser 
                165                 170                 175     


Trp Ser Asn Lys Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg 
            180                 185                 190         


Arg Pro Cys Ser Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro 
        195                 200                 205             


Pro His Thr Lys Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys 
    210                 215                 220                 


Thr Ser Lys Lys Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln 
225                 230                 235                 240 


Ala Lys Pro Thr Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn 
                245                 250                 255     


Asp Pro Lys Gly Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu 
            260                 265                 270         


Ser Val Glu Leu Ser Gly Thr Ala Gly Val Lys Thr Asn Leu Ile Ser 
        275                 280                 285             


Lys 
    


<210>  45
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGC1 Isoform 6

<400>  45

Met Asp Glu Thr Ser Pro Arg Leu Glu Glu Asp Trp Lys Lys Val Leu 
1               5                   10                  15      


Gln Arg Glu Ala Gly Trp Gln Cys Ala Ala Leu Val Gly Glu Asp Gln 
            20                  25                  30          


Pro Leu Cys Pro Asp Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val 
        35                  40                  45              


Asn Asp Leu Asp Thr Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser 
    50                  55                  60                  


Asp Gln Ser Glu Ile Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn 
65                  70                  75                  80  


Ile Phe Glu Lys Ile Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val 
                85                  90                  95      


Leu Thr Glu Thr Leu Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro 
            100                 105                 110         


Ser Phe Asp Ala Leu Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala 
        115                 120                 125             


Ser Pro Ser Ser Met Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu 
    130                 135                 140                 


Glu Pro Ser Leu Leu Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln 
145                 150                 155                 160 


Leu Ser Tyr Asn Glu Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn 
                165                 170                 175     


His Asn His Arg Ile Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn 
            180                 185                 190         


Ser Trp Ser Asn Lys Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln 
        195                 200                 205             


Arg Arg Pro Cys Ser Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp 
    210                 215                 220                 


Pro Pro His Thr Lys Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys 
225                 230                 235                 240 


Cys Thr Ser Lys Lys Lys Ser His Thr Gln Ser Gln Ser Gln His Leu 
                245                 250                 255     


Gln Ala Lys Pro Thr Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro 
            260                 265                 270         


Asn Leu Phe Leu 
        275     


<210>  46
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGC1 Isoform 7

<400>  46

Met Asp Glu Gly Tyr Phe Cys Ala Ala Leu Val Gly Glu Asp Gln Pro 
1               5                   10                  15      


Leu Cys Pro Asp Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn 
            20                  25                  30          


Asp Leu Asp Thr Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp 
        35                  40                  45              


Gln Ser Glu Ile Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile 
    50                  55                  60                  


Phe Glu Lys Ile Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu 
65                  70                  75                  80  


Thr Glu Thr Leu Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser 
                85                  90                  95      


Phe Asp Ala Leu Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser 
            100                 105                 110         


Pro Ser Ser Met Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu 
        115                 120                 125             


Pro Ser Leu Val Arg Thr Leu Pro Thr Val 
    130                 135             


<210>  47
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGC1 Isoform 8

<400>  47

Met Ala Trp Asp Met Cys Asn Gln Asp Ser Glu Ser Val Trp Ser Asp 
1               5                   10                  15      


Ile Glu Cys Ala Ala Leu Val Gly Glu Asp Gln Pro Leu Cys Pro Asp 
            20                  25                  30          


Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn Asp Leu Asp Thr 
        35                  40                  45              


Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp Gln Ser Glu Ile 
    50                  55                  60                  


Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile Phe Glu Lys Ile 
65                  70                  75                  80  


Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu Thr Glu Thr Leu 
                85                  90                  95      


Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser Phe Asp Ala Leu 
            100                 105                 110         


Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser Pro Ser Ser Met 
        115                 120                 125             


Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu Pro Ser Leu Leu 
    130                 135                 140                 


Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu Ser Tyr Asn Glu 
145                 150                 155                 160 


Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His Asn His Arg Ile 
                165                 170                 175     


Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser Trp Ser Asn Lys 
            180                 185                 190         


Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg Arg Pro Cys Ser 
        195                 200                 205             


Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro Pro His Thr Lys 
    210                 215                 220                 


Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys Thr Ser Lys Lys 
225                 230                 235                 240 


Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln Ala Lys Pro Thr 
                245                 250                 255     


Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn Asp Pro Lys Gly 
            260                 265                 270         


Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu Ser Val Glu Leu 
        275                 280                 285             


Ser Gly Thr Ala Gly Val Lys Thr Asn Leu Ile Ser Lys 
    290                 295                 300     


<210>  48
<211>  671
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGC1 Isoform 9

<400>  48

Met Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu Pro Ser Leu 
1               5                   10                  15      


Leu Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu Ser Tyr Asn 
            20                  25                  30          


Glu Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His Asn His Arg 
        35                  40                  45              


Ile Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser Trp Ser Asn 
    50                  55                  60                  


Lys Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg Arg Pro Cys 
65                  70                  75                  80  


Ser Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro Pro His Thr 
                85                  90                  95      


Lys Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys Thr Ser Lys 
            100                 105                 110         


Lys Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln Ala Lys Pro 
        115                 120                 125             


Thr Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn Asp Pro Lys 
    130                 135                 140                 


Gly Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu Ser Val Glu 
145                 150                 155                 160 


Leu Ser Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr Pro Pro His Lys 
                165                 170                 175     


Ala Asn Gln Asp Asn Pro Phe Arg Ala Ser Pro Lys Leu Lys Ser Ser 
            180                 185                 190         


Cys Lys Thr Val Val Pro Pro Pro Ser Lys Lys Pro Arg Tyr Ser Glu 
        195                 200                 205             


Ser Ser Gly Thr Gln Gly Asn Asn Ser Thr Lys Lys Gly Pro Glu Gln 
    210                 215                 220                 


Ser Glu Leu Tyr Ala Gln Leu Ser Lys Ser Ser Val Leu Thr Gly Gly 
225                 230                 235                 240 


His Glu Glu Arg Lys Thr Lys Arg Pro Ser Leu Arg Leu Phe Gly Asp 
                245                 250                 255     


His Asp Tyr Cys Gln Ser Ile Asn Ser Lys Thr Glu Ile Leu Ile Asn 
            260                 265                 270         


Ile Ser Gln Glu Leu Gln Asp Ser Arg Gln Leu Glu Asn Lys Asp Val 
        275                 280                 285             


Ser Ser Asp Trp Gln Gly Gln Ile Cys Ser Ser Thr Asp Ser Asp Gln 
    290                 295                 300                 


Cys Tyr Leu Arg Glu Thr Leu Glu Ala Ser Lys Gln Val Ser Pro Cys 
305                 310                 315                 320 


Ser Thr Arg Lys Gln Leu Gln Asp Gln Glu Ile Arg Ala Glu Leu Asn 
                325                 330                 335     


Lys His Phe Gly His Pro Ser Gln Ala Val Phe Asp Asp Glu Ala Asp 
            340                 345                 350         


Lys Thr Gly Glu Leu Arg Asp Ser Asp Phe Ser Asn Glu Gln Phe Ser 
        355                 360                 365             


Lys Leu Pro Met Phe Ile Asn Ser Gly Leu Ala Met Asp Gly Leu Phe 
    370                 375                 380                 


Asp Asp Ser Glu Asp Glu Ser Asp Lys Leu Ser Tyr Pro Trp Asp Gly 
385                 390                 395                 400 


Thr Gln Ser Tyr Ser Leu Phe Asn Val Ser Pro Ser Cys Ser Ser Phe 
                405                 410                 415     


Asn Ser Pro Cys Arg Asp Ser Val Ser Pro Pro Lys Ser Leu Phe Ser 
            420                 425                 430         


Gln Arg Pro Gln Arg Met Arg Ser Arg Ser Arg Ser Phe Ser Arg His 
        435                 440                 445             


Arg Ser Cys Ser Arg Ser Pro Tyr Ser Arg Ser Arg Ser Arg Ser Pro 
    450                 455                 460                 


Gly Ser Arg Ser Ser Ser Arg Ser Cys Tyr Tyr Tyr Glu Ser Ser His 
465                 470                 475                 480 


Tyr Arg His Arg Thr His Arg Asn Ser Pro Leu Tyr Val Arg Ser Arg 
                485                 490                 495     


Ser Arg Ser Pro Tyr Ser Arg Arg Pro Arg Tyr Asp Ser Tyr Glu Glu 
            500                 505                 510         


Tyr Gln His Glu Arg Leu Lys Arg Glu Glu Tyr Arg Arg Glu Tyr Glu 
        515                 520                 525             


Lys Arg Glu Ser Glu Arg Ala Lys Gln Arg Glu Arg Gln Arg Gln Lys 
    530                 535                 540                 


Ala Ile Glu Glu Arg Arg Val Ile Tyr Val Gly Lys Ile Arg Pro Asp 
545                 550                 555                 560 


Thr Thr Arg Thr Glu Leu Arg Asp Arg Phe Glu Val Phe Gly Glu Ile 
                565                 570                 575     


Glu Glu Cys Thr Val Asn Leu Arg Asp Asp Gly Asp Ser Tyr Gly Phe 
            580                 585                 590         


Ile Thr Tyr Arg Tyr Thr Cys Asp Ala Phe Ala Ala Leu Glu Asn Gly 
        595                 600                 605             


Tyr Thr Leu Arg Arg Ser Asn Glu Thr Asp Phe Glu Leu Tyr Phe Cys 
    610                 615                 620                 


Gly Arg Lys Gln Phe Phe Lys Ser Asn Tyr Ala Asp Leu Asp Ser Asn 
625                 630                 635                 640 


Ser Asp Asp Phe Asp Pro Ala Ser Thr Lys Ser Lys Tyr Asp Ser Leu 
                645                 650                 655     


Asp Phe Asp Ser Leu Leu Lys Glu Ala Gln Arg Ser Leu Arg Arg 
            660                 665                 670     


<210>  49
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  49
ucauaca                                                                  7


<210>  50
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  50
gaggcug                                                                  7


<210>  51
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  51
cgaggtcgac ttcctaga                                                     18


<210>  52
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  52
catacacggc tctcctctct aaa                                               23


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  53
tcctgtggca tccatgaaac                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  54
caatgcctgg gtacatggtg                                                   20


<210>  55
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  55
ccaagtggag gagcagct                                                     18


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  56
gacaaggtac aacccatcgg                                                   20


<210>  57
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  57
ttcgacacat gggataacga gg                                                22


<210>  58
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  58
tttttgctgt gagtcccgga g                                                 21


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  59
cagcctagca gcacgtaaat                                                   20


<210>  60
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  60
gaatcgagca ccagttacg                                                    19


<210>  61
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  61
ccttccctga aggttcctcc tt                                                22


<210>  62
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  62
tgtatga                                                                  7


<210>  63
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  63
gtgtatga                                                                 8


<210>  64
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  64
cgtgtatga                                                                9


<210>  65
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  65
ccgtgtatga                                                              10


<210>  66
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  66
gccgtgtatg a                                                            11


<210>  67
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  67
agccgtgtat ga                                                           12


<210>  68
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  68
gagccgtgta tga                                                          13


<210>  69
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  69
agagccgtgt atga                                                         14


<210>  70
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  70
gagagccgtg tatga                                                        15


<210>  71
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  71
ggagagccgt gtatga                                                       16


<210>  72
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  72
aggagagccg tgtatga                                                      17


<210>  73
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  73
gaggagagcc gtgtatga                                                     18


<210>  74
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  74
agaggagagc cgtgtatga                                                    19


<210>  75
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  75
gagaggagag ccgtgtatga                                                   20


<210>  76
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  76
tgtatgac                                                                 8


<210>  77
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  77
gtgtatgac                                                                9


<210>  78
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  78
cgtgtatgac                                                              10


<210>  79
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  79
ccgtgtatga c                                                            11


<210>  80
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  80
gccgtgtatg ac                                                           12


<210>  81
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  81
agccgtgtat gac                                                          13


<210>  82
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  82
gagccgtgta tgac                                                         14


<210>  83
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  83
agagccgtgt atgac                                                        15


<210>  84
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  84
gagagccgtg tatgac                                                       16


<210>  85
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  85
ggagagccgt gtatgac                                                      17


<210>  86
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  86
aggagagccg tgtatgac                                                     18


<210>  87
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  87
gaggagagcc gtgtatgac                                                    19


<210>  88
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  88
agaggagagc cgtgtatgac                                                   20


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  89
gagaggagag ccgtgtatga c                                                 21


<210>  90
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  90
agagaggaga gccgtgtatg ac                                                22


<210>  91
<211>  1473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP1 Isoform 1

<400>  91

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu 
1               5                   10                  15      


Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala 
            20                  25                  30          


His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr 
        35                  40                  45              


Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln 
    50                  55                  60                  


Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe 
                85                  90                  95      


Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr 
            100                 105                 110         


Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys 
        115                 120                 125             


Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser 
    130                 135                 140                 


Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu 
145                 150                 155                 160 


Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala 
                165                 170                 175     


Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro 
            180                 185                 190         


Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu 
        195                 200                 205             


Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg 
    210                 215                 220                 


Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr 
225                 230                 235                 240 


Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu 
                245                 250                 255     


Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu 
            260                 265                 270         


Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His 
        275                 280                 285             


Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val 
    290                 295                 300                 


Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala 
                325                 330                 335     


Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly 
            340                 345                 350         


Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser 
        355                 360                 365             


Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile 
    370                 375                 380                 


Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly 
                405                 410                 415     


Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln 
            420                 425                 430         


Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln 
    450                 455                 460                 


Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly 
465                 470                 475                 480 


Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp 
                485                 490                 495     


Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu 
            500                 505                 510         


Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr 
        515                 520                 525             


Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser 
    530                 535                 540                 


Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln 
545                 550                 555                 560 


Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala 
                565                 570                 575     


Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg 
            580                 585                 590         


Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly 
        595                 600                 605             


Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu 
    610                 615                 620                 


Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu 
625                 630                 635                 640 


Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr 
                645                 650                 655     


Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg 
            660                 665                 670         


Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn 
        675                 680                 685             


Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val 
    690                 695                 700                 


Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His 
705                 710                 715                 720 


Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala 
                725                 730                 735     


His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu 
            740                 745                 750         


Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln 
        755                 760                 765             


Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val 
    770                 775                 780                 


Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu 
785                 790                 795                 800 


Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser 
                805                 810                 815     


Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu 
            820                 825                 830         


Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly 
        835                 840                 845             


Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn 
    850                 855                 860                 


Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala 
865                 870                 875                 880 


Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu 
                885                 890                 895     


Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln 
            900                 905                 910         


Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp 
        915                 920                 925             


Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Leu Asp Gln 
945                 950                 955                 960 


Thr Thr Leu Ser Asp Glu Met Arg Gln Glu Leu Arg Ala Leu Glu Gln 
                965                 970                 975     


Glu Lys Pro Gln Leu Leu Ile Phe Ser Arg Arg Lys Pro Ser Val Met 
            980                 985                 990         


Thr Pro Thr Glu Gly Leu Asp Thr  Gly Glu Met Ser Asn  Ser Thr Ser 
        995                 1000                 1005             


Ser Leu  Lys Arg Gln Arg Leu  Gly Ser Glu Arg Ala  Ala Ser His 
    1010                 1015                 1020             


Val Ala  Gln Ala Asn Leu Lys  Leu Leu Asp Val Ser  Lys Ile Phe 
    1025                 1030                 1035             


Pro Ile  Ala Glu Ile Ala Glu  Glu Ser Ser Pro Glu  Val Val Pro 
    1040                 1045                 1050             


Val Glu  Leu Leu Cys Val Pro  Ser Pro Ala Ser Gln  Gly Asp Leu 
    1055                 1060                 1065             


His Thr  Lys Pro Leu Gly Thr  Asp Asp Asp Phe Trp  Gly Pro Thr 
    1070                 1075                 1080             


Gly Pro  Val Ala Thr Glu Val  Val Asp Lys Glu Lys  Asn Leu Tyr 
    1085                 1090                 1095             


Arg Val  His Phe Pro Val Ala  Gly Ser Tyr Arg Trp  Pro Asn Thr 
    1100                 1105                 1110             


Gly Leu  Cys Phe Val Met Arg  Glu Ala Val Thr Val  Glu Ile Glu 
    1115                 1120                 1125             


Phe Cys  Val Trp Asp Gln Phe  Leu Gly Glu Ile Asn  Pro Gln His 
    1130                 1135                 1140             


Ser Trp  Met Val Ala Gly Pro  Leu Leu Asp Ile Lys  Ala Glu Pro 
    1145                 1150                 1155             


Gly Ala  Val Glu Ala Val His  Leu Pro His Phe Val  Ala Leu Gln 
    1160                 1165                 1170             


Gly Gly  His Val Asp Thr Ser  Leu Phe Gln Met Ala  His Phe Lys 
    1175                 1180                 1185             


Glu Glu  Gly Met Leu Leu Glu  Lys Pro Ala Arg Val  Glu Leu His 
    1190                 1195                 1200             


His Ile  Val Leu Glu Asn Pro  Ser Phe Ser Pro Leu  Gly Val Leu 
    1205                 1210                 1215             


Leu Lys  Met Ile His Asn Ala  Leu Arg Phe Ile Pro  Val Thr Ser 
    1220                 1225                 1230             


Val Val  Leu Leu Tyr His Arg  Val His Pro Glu Glu  Val Thr Phe 
    1235                 1240                 1245             


His Leu  Tyr Leu Ile Pro Ser  Asp Cys Ser Ile Arg  Lys Ala Ile 
    1250                 1255                 1260             


Asp Asp  Leu Glu Met Lys Phe  Gln Phe Val Arg Ile  His Lys Pro 
    1265                 1270                 1275             


Pro Pro  Leu Thr Pro Leu Tyr  Met Gly Cys Arg Tyr  Thr Val Ser 
    1280                 1285                 1290             


Gly Ser  Gly Ser Gly Met Leu  Glu Ile Leu Pro Lys  Glu Leu Glu 
    1295                 1300                 1305             


Leu Cys  Tyr Arg Ser Pro Gly  Glu Asp Gln Leu Phe  Ser Glu Phe 
    1310                 1315                 1320             


Tyr Val  Gly His Leu Gly Ser  Gly Ile Arg Leu Gln  Val Lys Asp 
    1325                 1330                 1335             


Lys Lys  Asp Glu Thr Leu Val  Trp Glu Ala Leu Val  Lys Pro Gly 
    1340                 1345                 1350             


Asp Leu  Met Pro Ala Thr Thr  Leu Ile Pro Pro Ala  Arg Ile Ala 
    1355                 1360                 1365             


Val Pro  Ser Pro Leu Asp Ala  Pro Gln Leu Leu His  Phe Val Asp 
    1370                 1375                 1380             


Gln Tyr  Arg Glu Gln Leu Ile  Ala Arg Val Thr Ser  Val Glu Val 
    1385                 1390                 1395             


Val Leu  Asp Lys Leu His Gly  Gln Val Leu Ser Gln  Glu Gln Tyr 
    1400                 1405                 1410             


Glu Arg  Val Leu Ala Glu Asn  Thr Arg Pro Ser Gln  Met Arg Lys 
    1415                 1420                 1425             


Leu Phe  Ser Leu Ser Gln Ser  Trp Asp Arg Lys Cys  Lys Asp Gly 
    1430                 1435                 1440             


Leu Tyr  Gln Ala Leu Lys Glu  Thr His Pro His Leu  Ile Met Glu 
    1445                 1450                 1455             


Leu Trp  Glu Lys Gly Ser Lys  Lys Gly Leu Leu Pro  Leu Ser Ser 
    1460                 1465                 1470             


<210>  92
<211>  1429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP1 Isoform 2

<400>  92

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu 
1               5                   10                  15      


Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala 
            20                  25                  30          


His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr 
        35                  40                  45              


Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln 
    50                  55                  60                  


Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe 
                85                  90                  95      


Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr 
            100                 105                 110         


Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys 
        115                 120                 125             


Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser 
    130                 135                 140                 


Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu 
145                 150                 155                 160 


Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala 
                165                 170                 175     


Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro 
            180                 185                 190         


Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu 
        195                 200                 205             


Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg 
    210                 215                 220                 


Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr 
225                 230                 235                 240 


Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu 
                245                 250                 255     


Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu 
            260                 265                 270         


Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His 
        275                 280                 285             


Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val 
    290                 295                 300                 


Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala 
                325                 330                 335     


Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly 
            340                 345                 350         


Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser 
        355                 360                 365             


Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile 
    370                 375                 380                 


Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly 
                405                 410                 415     


Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln 
            420                 425                 430         


Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln 
    450                 455                 460                 


Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly 
465                 470                 475                 480 


Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp 
                485                 490                 495     


Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu 
            500                 505                 510         


Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr 
        515                 520                 525             


Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser 
    530                 535                 540                 


Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln 
545                 550                 555                 560 


Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala 
                565                 570                 575     


Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg 
            580                 585                 590         


Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly 
        595                 600                 605             


Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu 
    610                 615                 620                 


Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu 
625                 630                 635                 640 


Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr 
                645                 650                 655     


Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg 
            660                 665                 670         


Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn 
        675                 680                 685             


Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val 
    690                 695                 700                 


Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His 
705                 710                 715                 720 


Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala 
                725                 730                 735     


His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu 
            740                 745                 750         


Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln 
        755                 760                 765             


Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val 
    770                 775                 780                 


Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu 
785                 790                 795                 800 


Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser 
                805                 810                 815     


Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu 
            820                 825                 830         


Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly 
        835                 840                 845             


Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn 
    850                 855                 860                 


Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala 
865                 870                 875                 880 


Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu 
                885                 890                 895     


Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln 
            900                 905                 910         


Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp 
        915                 920                 925             


Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Leu Asp Gln 
945                 950                 955                 960 


Thr Thr Leu Ser Asp Glu Met Arg Gln Glu Leu Arg Ala Leu Glu Gln 
                965                 970                 975     


Glu Lys Pro Gln Leu Leu Ile Phe Ser Arg Arg Lys Pro Ser Val Met 
            980                 985                 990         


Thr Pro Thr Glu Gly Leu Asp Thr  Gly Glu Met Ser Asn  Ser Thr Ser 
        995                 1000                 1005             


Ser Leu  Lys Arg Gln Arg Leu  Gly Ser Glu Arg Ala  Ala Ser His 
    1010                 1015                 1020             


Val Ala  Gln Ala Asn Leu Lys  Leu Leu Asp Val Ser  Lys Ile Phe 
    1025                 1030                 1035             


Pro Ile  Ala Glu Ile Ala Glu  Glu Ser Ser Pro Glu  Val Val Pro 
    1040                 1045                 1050             


Val Glu  Leu Leu Cys Val Pro  Ser Pro Ala Ser Gln  Gly Asp Leu 
    1055                 1060                 1065             


His Thr  Lys Pro Leu Gly Thr  Asp Asp Asp Phe Trp  Gly Pro Thr 
    1070                 1075                 1080             


Gly Pro  Val Ala Thr Glu Val  Val Asp Lys Glu Lys  Asn Leu Tyr 
    1085                 1090                 1095             


Arg Val  His Phe Pro Val Ala  Gly Ser Tyr Arg Trp  Pro Asn Thr 
    1100                 1105                 1110             


Gly Leu  Cys Phe Val Met Arg  Glu Ala Val Thr Val  Glu Ile Glu 
    1115                 1120                 1125             


Phe Cys  Val Trp Asp Gln Phe  Leu Gly Glu Ile Asn  Pro Gln His 
    1130                 1135                 1140             


Ser Trp  Met Val Ala Gly Pro  Leu Leu Asp Ile Lys  Ala Glu Pro 
    1145                 1150                 1155             


Gly Ala  Val Glu Ala Val His  Leu Pro His Phe Val  Ala Leu Gln 
    1160                 1165                 1170             


Gly Gly  His Val Asp Thr Ser  Leu Phe Gln Met Ala  His Phe Lys 
    1175                 1180                 1185             


Glu Glu  Gly Met Leu Leu Glu  Lys Pro Ala Arg Val  Glu Leu His 
    1190                 1195                 1200             


His Ile  Val Leu Glu Asn Pro  Ser Phe Ser Pro Leu  Gly Val Leu 
    1205                 1210                 1215             


Leu Lys  Met Ile His Asn Ala  Leu Arg Phe Ile Pro  Val Thr Ser 
    1220                 1225                 1230             


Val Val  Leu Leu Tyr His Arg  Val His Pro Glu Glu  Val Thr Phe 
    1235                 1240                 1245             


His Leu  Tyr Leu Ile Pro Ser  Asp Cys Ser Ile Arg  Lys Glu Leu 
    1250                 1255                 1260             


Glu Leu  Cys Tyr Arg Ser Pro  Gly Glu Asp Gln Leu  Phe Ser Glu 
    1265                 1270                 1275             


Phe Tyr  Val Gly His Leu Gly  Ser Gly Ile Arg Leu  Gln Val Lys 
    1280                 1285                 1290             


Asp Lys  Lys Asp Glu Thr Leu  Val Trp Glu Ala Leu  Val Lys Pro 
    1295                 1300                 1305             


Gly Asp  Leu Met Pro Ala Thr  Thr Leu Ile Pro Pro  Ala Arg Ile 
    1310                 1315                 1320             


Ala Val  Pro Ser Pro Leu Asp  Ala Pro Gln Leu Leu  His Phe Val 
    1325                 1330                 1335             


Asp Gln  Tyr Arg Glu Gln Leu  Ile Ala Arg Val Thr  Ser Val Glu 
    1340                 1345                 1350             


Val Val  Leu Asp Lys Leu His  Gly Gln Val Leu Ser  Gln Glu Gln 
    1355                 1360                 1365             


Tyr Glu  Arg Val Leu Ala Glu  Asn Thr Arg Pro Ser  Gln Met Arg 
    1370                 1375                 1380             


Lys Leu  Phe Ser Leu Ser Gln  Ser Trp Asp Arg Lys  Cys Lys Asp 
    1385                 1390                 1395             


Gly Leu  Tyr Gln Ala Leu Lys  Glu Thr His Pro His  Leu Ile Met 
    1400                 1405                 1410             


Glu Leu  Trp Glu Lys Gly Ser  Lys Lys Gly Leu Leu  Pro Leu Ser 
    1415                 1420                 1425             


Ser 
    


<210>  93
<211>  1399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP1 Isoform 3

<400>  93

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu 
1               5                   10                  15      


Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala 
            20                  25                  30          


His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr 
        35                  40                  45              


Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln 
    50                  55                  60                  


Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe 
                85                  90                  95      


Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr 
            100                 105                 110         


Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys 
        115                 120                 125             


Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser 
    130                 135                 140                 


Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu 
145                 150                 155                 160 


Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala 
                165                 170                 175     


Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro 
            180                 185                 190         


Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu 
        195                 200                 205             


Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg 
    210                 215                 220                 


Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr 
225                 230                 235                 240 


Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu 
                245                 250                 255     


Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu 
            260                 265                 270         


Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His 
        275                 280                 285             


Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val 
    290                 295                 300                 


Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala 
                325                 330                 335     


Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly 
            340                 345                 350         


Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser 
        355                 360                 365             


Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile 
    370                 375                 380                 


Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly 
                405                 410                 415     


Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln 
            420                 425                 430         


Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln 
    450                 455                 460                 


Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly 
465                 470                 475                 480 


Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp 
                485                 490                 495     


Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu 
            500                 505                 510         


Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr 
        515                 520                 525             


Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser 
    530                 535                 540                 


Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln 
545                 550                 555                 560 


Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala 
                565                 570                 575     


Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg 
            580                 585                 590         


Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly 
        595                 600                 605             


Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu 
    610                 615                 620                 


Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu 
625                 630                 635                 640 


Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr 
                645                 650                 655     


Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg 
            660                 665                 670         


Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn 
        675                 680                 685             


Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val 
    690                 695                 700                 


Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His 
705                 710                 715                 720 


Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala 
                725                 730                 735     


His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu 
            740                 745                 750         


Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln 
        755                 760                 765             


Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val 
    770                 775                 780                 


Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu 
785                 790                 795                 800 


Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser 
                805                 810                 815     


Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu 
            820                 825                 830         


Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly 
        835                 840                 845             


Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn 
    850                 855                 860                 


Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala 
865                 870                 875                 880 


Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu 
                885                 890                 895     


Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln 
            900                 905                 910         


Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp 
        915                 920                 925             


Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Lys Pro Ser 
945                 950                 955                 960 


Val Met Thr Pro Thr Glu Gly Leu Asp Thr Gly Glu Met Ser Asn Ser 
                965                 970                 975     


Thr Ser Ser Leu Lys Arg Gln Arg Leu Gly Ser Glu Arg Ala Ala Ser 
            980                 985                 990         


His Val Ala Gln Ala Asn Leu Lys  Leu Leu Asp Val Ser  Lys Ile Phe 
        995                 1000                 1005             


Pro Ile  Ala Glu Ile Ala Glu  Glu Ser Ser Pro Glu  Val Val Pro 
    1010                 1015                 1020             


Val Glu  Leu Leu Cys Val Pro  Ser Pro Ala Ser Gln  Gly Asp Leu 
    1025                 1030                 1035             


His Thr  Lys Pro Leu Gly Thr  Asp Asp Asp Phe Trp  Gly Pro Thr 
    1040                 1045                 1050             


Gly Pro  Val Ala Thr Glu Val  Val Asp Lys Glu Lys  Asn Leu Tyr 
    1055                 1060                 1065             


Arg Val  His Phe Pro Val Ala  Gly Ser Tyr Arg Trp  Pro Asn Thr 
    1070                 1075                 1080             


Gly Leu  Cys Phe Val Met Arg  Glu Ala Val Thr Val  Glu Ile Glu 
    1085                 1090                 1095             


Phe Cys  Val Trp Asp Gln Phe  Leu Gly Glu Ile Asn  Pro Gln His 
    1100                 1105                 1110             


Ser Trp  Met Val Ala Gly Pro  Leu Leu Asp Ile Lys  Ala Glu Pro 
    1115                 1120                 1125             


Gly Ala  Val Glu Ala Val His  Leu Pro His Phe Val  Ala Leu Gln 
    1130                 1135                 1140             


Gly Gly  His Val Asp Thr Ser  Leu Phe Gln Met Ala  His Phe Lys 
    1145                 1150                 1155             


Glu Glu  Gly Met Leu Leu Glu  Lys Pro Ala Arg Val  Glu Leu His 
    1160                 1165                 1170             


His Ile  Val Leu Glu Asn Pro  Ser Phe Ser Pro Leu  Gly Val Leu 
    1175                 1180                 1185             


Leu Lys  Met Ile His Asn Ala  Leu Arg Phe Ile Pro  Val Thr Ser 
    1190                 1195                 1200             


Val Val  Leu Leu Tyr His Arg  Val His Pro Glu Glu  Val Thr Phe 
    1205                 1210                 1215             


His Leu  Tyr Leu Ile Pro Ser  Asp Cys Ser Ile Arg  Lys Glu Leu 
    1220                 1225                 1230             


Glu Leu  Cys Tyr Arg Ser Pro  Gly Glu Asp Gln Leu  Phe Ser Glu 
    1235                 1240                 1245             


Phe Tyr  Val Gly His Leu Gly  Ser Gly Ile Arg Leu  Gln Val Lys 
    1250                 1255                 1260             


Asp Lys  Lys Asp Glu Thr Leu  Val Trp Glu Ala Leu  Val Lys Pro 
    1265                 1270                 1275             


Gly Asp  Leu Met Pro Ala Thr  Thr Leu Ile Pro Pro  Ala Arg Ile 
    1280                 1285                 1290             


Ala Val  Pro Ser Pro Leu Asp  Ala Pro Gln Leu Leu  His Phe Val 
    1295                 1300                 1305             


Asp Gln  Tyr Arg Glu Gln Leu  Ile Ala Arg Val Thr  Ser Val Glu 
    1310                 1315                 1320             


Val Val  Leu Asp Lys Leu His  Gly Gln Val Leu Ser  Gln Glu Gln 
    1325                 1330                 1335             


Tyr Glu  Arg Val Leu Ala Glu  Asn Thr Arg Pro Ser  Gln Met Arg 
    1340                 1345                 1350             


Lys Leu  Phe Ser Leu Ser Gln  Ser Trp Asp Arg Lys  Cys Lys Asp 
    1355                 1360                 1365             


Gly Leu  Tyr Gln Ala Leu Lys  Glu Thr His Pro His  Leu Ile Met 
    1370                 1375                 1380             


Glu Leu  Trp Glu Lys Gly Ser  Lys Lys Gly Leu Leu  Pro Leu Ser 
    1385                 1390                 1395             


Ser 
    


<210>  94
<211>  1443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP1 Isoform 4

<400>  94

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu 
1               5                   10                  15      


Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala 
            20                  25                  30          


His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr 
        35                  40                  45              


Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln 
    50                  55                  60                  


Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe 
                85                  90                  95      


Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr 
            100                 105                 110         


Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys 
        115                 120                 125             


Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser 
    130                 135                 140                 


Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu 
145                 150                 155                 160 


Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala 
                165                 170                 175     


Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro 
            180                 185                 190         


Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu 
        195                 200                 205             


Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg 
    210                 215                 220                 


Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr 
225                 230                 235                 240 


Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu 
                245                 250                 255     


Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu 
            260                 265                 270         


Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His 
        275                 280                 285             


Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val 
    290                 295                 300                 


Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala 
                325                 330                 335     


Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly 
            340                 345                 350         


Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser 
        355                 360                 365             


Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile 
    370                 375                 380                 


Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly 
                405                 410                 415     


Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln 
            420                 425                 430         


Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln 
    450                 455                 460                 


Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly 
465                 470                 475                 480 


Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp 
                485                 490                 495     


Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu 
            500                 505                 510         


Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr 
        515                 520                 525             


Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser 
    530                 535                 540                 


Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln 
545                 550                 555                 560 


Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala 
                565                 570                 575     


Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg 
            580                 585                 590         


Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly 
        595                 600                 605             


Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu 
    610                 615                 620                 


Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu 
625                 630                 635                 640 


Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr 
                645                 650                 655     


Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg 
            660                 665                 670         


Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn 
        675                 680                 685             


Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val 
    690                 695                 700                 


Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His 
705                 710                 715                 720 


Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala 
                725                 730                 735     


His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu 
            740                 745                 750         


Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln 
        755                 760                 765             


Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val 
    770                 775                 780                 


Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu 
785                 790                 795                 800 


Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser 
                805                 810                 815     


Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu 
            820                 825                 830         


Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly 
        835                 840                 845             


Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn 
    850                 855                 860                 


Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala 
865                 870                 875                 880 


Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu 
                885                 890                 895     


Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln 
            900                 905                 910         


Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp 
        915                 920                 925             


Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Lys Pro Ser 
945                 950                 955                 960 


Val Met Thr Pro Thr Glu Gly Leu Asp Thr Gly Glu Met Ser Asn Ser 
                965                 970                 975     


Thr Ser Ser Leu Lys Arg Gln Arg Leu Gly Ser Glu Arg Ala Ala Ser 
            980                 985                 990         


His Val Ala Gln Ala Asn Leu Lys  Leu Leu Asp Val Ser  Lys Ile Phe 
        995                 1000                 1005             


Pro Ile  Ala Glu Ile Ala Glu  Glu Ser Ser Pro Glu  Val Val Pro 
    1010                 1015                 1020             


Val Glu  Leu Leu Cys Val Pro  Ser Pro Ala Ser Gln  Gly Asp Leu 
    1025                 1030                 1035             


His Thr  Lys Pro Leu Gly Thr  Asp Asp Asp Phe Trp  Gly Pro Thr 
    1040                 1045                 1050             


Gly Pro  Val Ala Thr Glu Val  Val Asp Lys Glu Lys  Asn Leu Tyr 
    1055                 1060                 1065             


Arg Val  His Phe Pro Val Ala  Gly Ser Tyr Arg Trp  Pro Asn Thr 
    1070                 1075                 1080             


Gly Leu  Cys Phe Val Met Arg  Glu Ala Val Thr Val  Glu Ile Glu 
    1085                 1090                 1095             


Phe Cys  Val Trp Asp Gln Phe  Leu Gly Glu Ile Asn  Pro Gln His 
    1100                 1105                 1110             


Ser Trp  Met Val Ala Gly Pro  Leu Leu Asp Ile Lys  Ala Glu Pro 
    1115                 1120                 1125             


Gly Ala  Val Glu Ala Val His  Leu Pro His Phe Val  Ala Leu Gln 
    1130                 1135                 1140             


Gly Gly  His Val Asp Thr Ser  Leu Phe Gln Met Ala  His Phe Lys 
    1145                 1150                 1155             


Glu Glu  Gly Met Leu Leu Glu  Lys Pro Ala Arg Val  Glu Leu His 
    1160                 1165                 1170             


His Ile  Val Leu Glu Asn Pro  Ser Phe Ser Pro Leu  Gly Val Leu 
    1175                 1180                 1185             


Leu Lys  Met Ile His Asn Ala  Leu Arg Phe Ile Pro  Val Thr Ser 
    1190                 1195                 1200             


Val Val  Leu Leu Tyr His Arg  Val His Pro Glu Glu  Val Thr Phe 
    1205                 1210                 1215             


His Leu  Tyr Leu Ile Pro Ser  Asp Cys Ser Ile Arg  Lys Ala Ile 
    1220                 1225                 1230             


Asp Asp  Leu Glu Met Lys Phe  Gln Phe Val Arg Ile  His Lys Pro 
    1235                 1240                 1245             


Pro Pro  Leu Thr Pro Leu Tyr  Met Gly Cys Arg Tyr  Thr Val Ser 
    1250                 1255                 1260             


Gly Ser  Gly Ser Gly Met Leu  Glu Ile Leu Pro Lys  Glu Leu Glu 
    1265                 1270                 1275             


Leu Cys  Tyr Arg Ser Pro Gly  Glu Asp Gln Leu Phe  Ser Glu Phe 
    1280                 1285                 1290             


Tyr Val  Gly His Leu Gly Ser  Gly Ile Arg Leu Gln  Val Lys Asp 
    1295                 1300                 1305             


Lys Lys  Asp Glu Thr Leu Val  Trp Glu Ala Leu Val  Lys Pro Gly 
    1310                 1315                 1320             


Asp Leu  Met Pro Ala Thr Thr  Leu Ile Pro Pro Ala  Arg Ile Ala 
    1325                 1330                 1335             


Val Pro  Ser Pro Leu Asp Ala  Pro Gln Leu Leu His  Phe Val Asp 
    1340                 1345                 1350             


Gln Tyr  Arg Glu Gln Leu Ile  Ala Arg Val Thr Ser  Val Glu Val 
    1355                 1360                 1365             


Val Leu  Asp Lys Leu His Gly  Gln Val Leu Ser Gln  Glu Gln Tyr 
    1370                 1375                 1380             


Glu Arg  Val Leu Ala Glu Asn  Thr Arg Pro Ser Gln  Met Arg Lys 
    1385                 1390                 1395             


Leu Phe  Ser Leu Ser Gln Ser  Trp Asp Arg Lys Cys  Lys Asp Gly 
    1400                 1405                 1410             


Leu Tyr  Gln Ala Leu Lys Glu  Thr His Pro His Leu  Ile Met Glu 
    1415                 1420                 1425             


Leu Trp  Glu Lys Gly Ser Lys  Lys Gly Leu Leu Pro  Leu Ser Ser 
    1430                 1435                 1440             


<210>  95
<211>  1375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP1 Isoform 5

<400>  95

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu 
1               5                   10                  15      


Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala 
            20                  25                  30          


His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr 
        35                  40                  45              


Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln 
    50                  55                  60                  


Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe 
                85                  90                  95      


Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr 
            100                 105                 110         


Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys 
        115                 120                 125             


Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser 
    130                 135                 140                 


Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu 
145                 150                 155                 160 


Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala 
                165                 170                 175     


Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro 
            180                 185                 190         


Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu 
        195                 200                 205             


Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg 
    210                 215                 220                 


Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr 
225                 230                 235                 240 


Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu 
                245                 250                 255     


Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu 
            260                 265                 270         


Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His 
        275                 280                 285             


Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val 
    290                 295                 300                 


Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala 
                325                 330                 335     


Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly 
            340                 345                 350         


Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser 
        355                 360                 365             


Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile 
    370                 375                 380                 


Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly 
                405                 410                 415     


Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln 
            420                 425                 430         


Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln 
    450                 455                 460                 


Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly 
465                 470                 475                 480 


Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp 
                485                 490                 495     


Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu 
            500                 505                 510         


Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr 
        515                 520                 525             


Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser 
    530                 535                 540                 


Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln 
545                 550                 555                 560 


Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala 
                565                 570                 575     


Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg 
            580                 585                 590         


Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly 
        595                 600                 605             


Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu 
    610                 615                 620                 


Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu 
625                 630                 635                 640 


Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr 
                645                 650                 655     


Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg 
            660                 665                 670         


Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn 
        675                 680                 685             


Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val 
    690                 695                 700                 


Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His 
705                 710                 715                 720 


Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala 
                725                 730                 735     


His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu 
            740                 745                 750         


Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln 
        755                 760                 765             


Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val 
    770                 775                 780                 


Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu 
785                 790                 795                 800 


Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser 
                805                 810                 815     


Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu 
            820                 825                 830         


Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly 
        835                 840                 845             


Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn 
    850                 855                 860                 


Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala 
865                 870                 875                 880 


Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu 
                885                 890                 895     


Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln 
            900                 905                 910         


Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp 
        915                 920                 925             


Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Leu Asp Gln 
945                 950                 955                 960 


Thr Thr Leu Ser Asp Glu Met Arg Gln Glu Leu Arg Ala Leu Glu Gln 
                965                 970                 975     


Glu Lys Pro Gln Leu Leu Ile Phe Ser Arg Arg Lys Pro Ser Val Met 
            980                 985                 990         


Thr Pro Thr Glu Gly Leu Asp Thr  Gly Glu Met Ser Asn  Ser Thr Ser 
        995                 1000                 1005             


Ser Leu  Lys Arg Gln Arg Leu  Gly Ser Glu Arg Ala  Ala Ser His 
    1010                 1015                 1020             


Val Ala  Gln Ala Asn Leu Lys  Leu Leu Asp Val Ser  Lys Ile Phe 
    1025                 1030                 1035             


Pro Ile  Ala Glu Ile Ala Gly  Lys Ser His Glu Glu  Ser Ser Pro 
    1040                 1045                 1050             


Glu Val  Val Pro Val Glu Leu  Leu Cys Val Pro Ser  Pro Ala Ser 
    1055                 1060                 1065             


Gln Gly  Asp Leu His Thr Lys  Pro Leu Gly Thr Asp  Asp Asp Phe 
    1070                 1075                 1080             


Trp Gly  Pro Thr Gly Pro Val  Ala Thr Glu Val Val  Asp Lys Glu 
    1085                 1090                 1095             


Lys Asn  Leu Tyr Arg Val His  Phe Pro Val Ala Gly  Ser Tyr Arg 
    1100                 1105                 1110             


Trp Pro  Asn Thr Gly Leu Cys  Phe Val Met Arg Glu  Ala Val Thr 
    1115                 1120                 1125             


Val Glu  Ile Glu Phe Cys Val  Trp Asp Gln Phe Leu  Gly Glu Ile 
    1130                 1135                 1140             


Asn Pro  Gln His Ser Trp Met  Val Ala Gly Pro Leu  Leu Asp Ile 
    1145                 1150                 1155             


Lys Ala  Glu Pro Gly Ala Val  Glu Ala Val His Leu  Pro His Phe 
    1160                 1165                 1170             


Val Ala  Leu Gln Gly Gly His  Val Asp Thr Ser Leu  Phe Gln Met 
    1175                 1180                 1185             


Ala His  Phe Lys Glu Glu Gly  Met Leu Leu Glu Lys  Pro Ala Arg 
    1190                 1195                 1200             


Val Glu  Leu His His Ile Val  Leu Glu Asn Pro Ser  Phe Ser Pro 
    1205                 1210                 1215             


Leu Gly  Val Leu Leu Lys Met  Ile His Asn Ala Leu  Arg Phe Ile 
    1220                 1225                 1230             


Pro Val  Thr Ser Val Val Leu  Leu Tyr His Arg Val  His Pro Glu 
    1235                 1240                 1245             


Glu Val  Thr Phe His Leu Tyr  Leu Ile Pro Ser Asp  Cys Ser Ile 
    1250                 1255                 1260             


Arg Lys  Ala Ile Asp Asp Leu  Glu Met Lys Phe Gln  Phe Val Arg 
    1265                 1270                 1275             


Ile His  Lys Pro Pro Pro Leu  Thr Pro Leu Tyr Met  Gly Cys Arg 
    1280                 1285                 1290             


Tyr Thr  Val Ser Gly Ser Gly  Ser Gly Met Leu Glu  Ile Leu Pro 
    1295                 1300                 1305             


Lys Glu  Leu Glu Leu Cys Tyr  Arg Ser Pro Gly Glu  Asp Gln Leu 
    1310                 1315                 1320             


Phe Ser  Glu Phe Tyr Val Gly  His Leu Gly Ser Gly  Ile Arg Leu 
    1325                 1330                 1335             


Gln Val  Lys Asp Lys Lys Asp  Glu Thr Leu Val Trp  Glu Ala Leu 
    1340                 1345                 1350             


Val Lys  Pro Gly Arg Asn Thr  Ser Gln Pro Trp Asn  Leu Arg Cys 
    1355                 1360                 1365             


Asn Arg  Asp Ala Arg Arg Tyr  
    1370                 1375 


<210>  96
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP1 Isoform 6

<400>  96

Met Ala His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu 
1               5                   10                  15      


Leu Leu Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys 
            20                  25                  30          


Leu Gln Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr 
        35                  40                  45              


Met Val Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln 
    50                  55                  60                  


Ile Leu Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp 
65                  70                  75                  80  


Leu Ser Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys 
                85                  90                  95      


Thr Leu Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly 
            100                 105                 110         


Cys Gly Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg 
        115                 120                 125             


Ala Asn Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr 
    130                 135                 140                 


Asp Ala Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys 
145                 150                 155                 160 


Lys Leu Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys 
                165                 170                 175     


Cys Gln Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu 
            180                 185                 190         


Leu Asp Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu 
        195                 200                 205             


Cys Glu Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Leu 
    210                 215                 220                 


Asp Gln Thr Thr Leu Ser Asp Glu Met Arg Gln Glu Leu Arg Ala Leu 
225                 230                 235                 240 


Glu Gln Glu Lys Pro Gln Leu Leu Ile Phe Ser Arg Arg Lys Pro Ser 
                245                 250                 255     


Val Met Thr Pro Thr Glu Gly Leu Asp Thr Gly Glu Met Ser Asn Ser 
            260                 265                 270         


Thr Ser Ser Leu Lys Arg Gln Arg Leu Gly Ser Glu Arg Ala Ala Ser 
        275                 280                 285             


His Val Ala Gln Ala Asn Leu Lys Leu Leu Asp Val Ser Lys Ile Phe 
    290                 295                 300                 


Pro Ile Ala Glu Ile Ala Glu Glu Ser Ser Pro Glu Val Val Pro Val 
305                 310                 315                 320 


Glu Leu Leu Cys Val Pro Ser Pro Ala Ser Gln Gly Asp Leu His Thr 
                325                 330                 335     


Lys Pro Leu Gly Thr Asp Asp Asp Phe Trp Gly Pro Thr Gly Pro Val 
            340                 345                 350         


Ala Thr Glu Val Val Asp Lys Glu Lys Asn Leu Tyr Arg Val His Phe 
        355                 360                 365             


Pro Val Ala Gly Ser Tyr Arg Trp Pro Asn Thr Gly Leu Cys Phe Val 
    370                 375                 380                 


Met Arg Glu Ala Val Thr Val Glu Ile Glu Phe Cys Val Trp Asp Gln 
385                 390                 395                 400 


Phe Leu Gly Glu Ile Asn Pro Gln His Ser Trp Met Val Ala Gly Pro 
                405                 410                 415     


Leu Leu Asp Ile Lys Ala Glu Pro Gly Ala Val Glu Ala Val His Leu 
            420                 425                 430         


Pro His Phe Val Ala Leu Gln Gly Gly His Val Asp Thr Ser Leu Phe 
        435                 440                 445             


Gln Met Ala His Phe Lys Glu Glu Gly Met Leu Leu Glu Lys Pro Ala 
    450                 455                 460                 


Arg Val Glu Leu His His Ile Val Leu Glu Asn Pro Ser Phe Ser Pro 
465                 470                 475                 480 


Leu Gly Val Leu Leu Lys Met Ile His Asn Ala Leu Arg Phe Ile Pro 
                485                 490                 495     


Val Thr Ser Val Val Leu Leu Tyr His Arg Val His Pro Glu Glu Val 
            500                 505                 510         


Thr Phe His Leu Tyr Leu Ile Pro Ser Asp Cys Ser Ile Arg Lys Ala 
        515                 520                 525             


Ile Asp Asp Leu Glu Met Lys Phe Gln Phe Val Arg Ile His Lys Pro 
    530                 535                 540                 


Pro Pro Leu Thr Pro Leu Tyr Met Gly Cys Arg Tyr Thr Val Ser Gly 
545                 550                 555                 560 


Ser Gly Ser Gly Met Leu Glu Ile Leu Pro Lys Glu Leu Glu Leu Cys 
                565                 570                 575     


Tyr Arg Ser Pro Gly Glu Asp Gln Leu Phe Ser Glu Phe Tyr Val Gly 
            580                 585                 590         


His Leu Gly Ser Gly Ile Arg Leu Gln Val Lys Asp Lys Lys Asp Glu 
        595                 600                 605             


Thr Leu Val Trp Glu Ala Leu Val Lys Pro Gly Asp Leu Met Pro Ala 
    610                 615                 620                 


Thr Thr Leu Ile Pro Pro Ala Arg Ile Ala Val Pro Ser Pro Leu Asp 
625                 630                 635                 640 


Ala Pro Gln Leu Leu His Phe Val Asp Gln Tyr Arg Glu Gln Leu Ile 
                645                 650                 655     


Ala Arg Val Thr Ser Val Glu Val Val Leu Asp Lys Leu His Gly Gln 
            660                 665                 670         


Val Leu Ser Gln Glu Gln Tyr Glu Arg Val Leu Ala Glu Asn Thr Arg 
        675                 680                 685             


Pro Ser Gln Met Arg Lys Leu Phe Ser Leu Ser Gln Ser Trp Asp Arg 
    690                 695                 700                 


Lys Cys Lys Asp Gly Leu Tyr Gln Ala Leu Lys Glu Thr His Pro His 
705                 710                 715                 720 


Leu Ile Met Glu Leu Trp Glu Lys Gly Ser Lys Lys Gly Leu Leu Pro 
                725                 730                 735     


Leu Ser Ser 
            


<210>  97
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP1 Isoform 7

<400>  97

Met Arg Gln Glu Leu Arg Ala Leu Glu Gln Glu Lys Pro Gln Leu Leu 
1               5                   10                  15      


Ile Phe Ser Arg Arg Lys Pro Ser Val Met Thr Pro Thr Glu Gly Leu 
            20                  25                  30          


Asp Thr Gly Glu Met Ser Asn Ser Thr Ser Ser Leu Lys Arg Gln Arg 
        35                  40                  45              


Leu Gly Ser Glu Arg Ala Ala Ser His Val Ala Gln Ala Asn Leu Lys 
    50                  55                  60                  


Leu Leu Asp Val Ser Lys Ile Phe Pro Ile Ala Glu Ile Ala Gly Lys 
65                  70                  75                  80  


Ser His Glu Glu Ser Ser Pro Glu Val Val Pro Val Glu Leu Leu Cys 
                85                  90                  95      


Val Pro Ser Pro Ala Ser Gln Gly Asp Leu His Thr Lys Pro Leu Gly 
            100                 105                 110         


Thr Asp Asp Asp Phe Trp Gly Pro Thr Gly Pro Val Ala Thr Glu Val 
        115                 120                 125             


Val Asp Lys Glu Lys Asn Leu Tyr Arg Val His Phe Pro Val Ala Gly 
    130                 135                 140                 


Ser Tyr Arg Trp Pro Asn Thr Gly Leu Cys Phe Val Met Arg Glu Ala 
145                 150                 155                 160 


Val Thr Val Glu Ile Glu Phe Cys Val Trp Asp Gln Phe Leu Gly Glu 
                165                 170                 175     


Ile Asn Pro Gln His Ser Trp Met Val Ala Gly Pro Leu Leu Asp Ile 
            180                 185                 190         


Lys Ala Glu Pro Gly Ala Val Glu Ala Val His Leu Pro His Phe Val 
        195                 200                 205             


Ala Leu Gln Gly Gly His Val Asp Thr Ser Leu Phe Gln Met Ala His 
    210                 215                 220                 


Phe Lys Glu Glu Gly Met Leu Leu Glu Lys Pro Ala Arg Val Glu Leu 
225                 230                 235                 240 


His His Ile Val Leu Glu Asn Pro Ser Phe Ser Pro Leu Gly Val Leu 
                245                 250                 255     


Leu Lys Met Ile His Asn Ala Leu Arg Phe Ile Pro Val Thr Ser Val 
            260                 265                 270         


Val Leu Leu Tyr His Arg Val His Pro Glu Glu Val Thr Phe His Leu 
        275                 280                 285             


Tyr Leu Ile Pro Ser Asp Cys Ser Ile Arg Lys Ala Ile Asp Asp Leu 
    290                 295                 300                 


Glu Met Lys Phe Gln Phe Val Arg Ile His Lys Pro Pro Pro Leu Thr 
305                 310                 315                 320 


Pro Leu Tyr Met Gly Cys Arg Tyr Thr Val Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Met Leu Glu Ile Leu Pro Lys Glu Leu Glu Leu Cys Tyr Arg Ser Pro 
            340                 345                 350         


Gly Glu Asp Gln Leu Phe Ser Glu Phe Tyr Val Gly His Leu Gly Ser 
        355                 360                 365             


Gly Ile Arg Leu Gln Val Lys Asp Lys Lys Asp Glu Thr Leu Val Trp 
    370                 375                 380                 


Glu Ala Leu Val Lys Pro Gly Arg Asn Thr Ser Gln Pro Trp Asn Leu 
385                 390                 395                 400 


Arg Cys Asn Arg Asp Ala Arg Arg Tyr 
                405                 


<210>  98
<211>  1024
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRC4 Isoform 1

<400>  98

Met Asn Phe Ile Lys Asp Asn Ser Arg Ala Leu Ile Gln Arg Met Gly 
1               5                   10                  15      


Met Thr Val Ile Lys Gln Ile Thr Asp Asp Leu Phe Val Trp Asn Val 
            20                  25                  30          


Leu Asn Arg Glu Glu Val Asn Ile Ile Cys Cys Glu Lys Val Glu Gln 
        35                  40                  45              


Asp Ala Ala Arg Gly Ile Ile His Met Ile Leu Lys Lys Gly Ser Glu 
    50                  55                  60                  


Ser Cys Asn Leu Phe Leu Lys Ser Leu Lys Glu Trp Asn Tyr Pro Leu 
65                  70                  75                  80  


Phe Gln Asp Leu Asn Gly Gln Ser Leu Phe His Gln Thr Ser Glu Gly 
                85                  90                  95      


Asp Leu Asp Asp Leu Ala Gln Asp Leu Lys Asp Leu Tyr His Thr Pro 
            100                 105                 110         


Ser Phe Leu Asn Phe Tyr Pro Leu Gly Glu Asp Ile Asp Ile Ile Phe 
        115                 120                 125             


Asn Leu Lys Ser Thr Phe Thr Glu Pro Val Leu Trp Arg Lys Asp Gln 
    130                 135                 140                 


His His His Arg Val Glu Gln Leu Thr Leu Asn Gly Leu Leu Gln Ala 
145                 150                 155                 160 


Leu Gln Ser Pro Cys Ile Ile Glu Gly Glu Ser Gly Lys Gly Lys Ser 
                165                 170                 175     


Thr Leu Leu Gln Arg Ile Ala Met Leu Trp Gly Ser Gly Lys Cys Lys 
            180                 185                 190         


Ala Leu Thr Lys Phe Lys Phe Val Phe Phe Leu Arg Leu Ser Arg Ala 
        195                 200                 205             


Gln Gly Gly Leu Phe Glu Thr Leu Cys Asp Gln Leu Leu Asp Ile Pro 
    210                 215                 220                 


Gly Thr Ile Arg Lys Gln Thr Phe Met Ala Met Leu Leu Lys Leu Arg 
225                 230                 235                 240 


Gln Arg Val Leu Phe Leu Leu Asp Gly Tyr Asn Glu Phe Lys Pro Gln 
                245                 250                 255     


Asn Cys Pro Glu Ile Glu Ala Leu Ile Lys Glu Asn His Arg Phe Lys 
            260                 265                 270         


Asn Met Val Ile Val Thr Thr Thr Thr Glu Cys Leu Arg His Ile Arg 
        275                 280                 285             


Gln Phe Gly Ala Leu Thr Ala Glu Val Gly Asp Met Thr Glu Asp Ser 
    290                 295                 300                 


Ala Gln Ala Leu Ile Arg Glu Val Leu Ile Lys Glu Leu Ala Glu Gly 
305                 310                 315                 320 


Leu Leu Leu Gln Ile Gln Lys Ser Arg Cys Leu Arg Asn Leu Met Lys 
                325                 330                 335     


Thr Pro Leu Phe Val Val Ile Thr Cys Ala Ile Gln Met Gly Glu Ser 
            340                 345                 350         


Glu Phe His Ser His Thr Gln Thr Thr Leu Phe His Thr Phe Tyr Asp 
        355                 360                 365             


Leu Leu Ile Gln Lys Asn Lys His Lys His Lys Gly Val Ala Ala Ser 
    370                 375                 380                 


Asp Phe Ile Arg Ser Leu Asp His Cys Gly Asp Leu Ala Leu Glu Gly 
385                 390                 395                 400 


Val Phe Ser His Lys Phe Asp Phe Glu Leu Gln Asp Val Ser Ser Val 
                405                 410                 415     


Asn Glu Asp Val Leu Leu Thr Thr Gly Leu Leu Cys Lys Tyr Thr Ala 
            420                 425                 430         


Gln Arg Phe Lys Pro Lys Tyr Lys Phe Phe His Lys Ser Phe Gln Glu 
        435                 440                 445             


Tyr Thr Ala Gly Arg Arg Leu Ser Ser Leu Leu Thr Ser His Glu Pro 
    450                 455                 460                 


Glu Glu Val Thr Lys Gly Asn Gly Tyr Leu Gln Lys Met Val Ser Ile 
465                 470                 475                 480 


Ser Asp Ile Thr Ser Thr Tyr Ser Ser Leu Leu Arg Tyr Thr Cys Gly 
                485                 490                 495     


Ser Ser Val Glu Ala Thr Arg Ala Val Met Lys His Leu Ala Ala Val 
            500                 505                 510         


Tyr Gln His Gly Cys Leu Leu Gly Leu Ser Ile Ala Lys Arg Pro Leu 
        515                 520                 525             


Trp Arg Gln Glu Ser Leu Gln Ser Val Lys Asn Thr Thr Glu Gln Glu 
    530                 535                 540                 


Ile Leu Lys Ala Ile Asn Ile Asn Ser Phe Val Glu Cys Gly Ile His 
545                 550                 555                 560 


Leu Tyr Gln Glu Ser Thr Ser Lys Ser Ala Leu Ser Gln Glu Phe Glu 
                565                 570                 575     


Ala Phe Phe Gln Gly Lys Ser Leu Tyr Ile Asn Ser Gly Asn Ile Pro 
            580                 585                 590         


Asp Tyr Leu Phe Asp Phe Phe Glu His Leu Pro Asn Cys Ala Ser Ala 
        595                 600                 605             


Leu Asp Phe Ile Lys Leu Asp Phe Tyr Gly Gly Ala Met Ala Ser Trp 
    610                 615                 620                 


Glu Lys Ala Ala Glu Asp Thr Gly Gly Ile His Met Glu Glu Ala Pro 
625                 630                 635                 640 


Glu Thr Tyr Ile Pro Ser Arg Ala Val Ser Leu Phe Phe Asn Trp Lys 
                645                 650                 655     


Gln Glu Phe Arg Thr Leu Glu Val Thr Leu Arg Asp Phe Ser Lys Leu 
            660                 665                 670         


Asn Lys Gln Asp Ile Arg Tyr Leu Gly Lys Ile Phe Ser Ser Ala Thr 
        675                 680                 685             


Ser Leu Arg Leu Gln Ile Lys Arg Cys Ala Gly Val Ala Gly Ser Leu 
    690                 695                 700                 


Ser Leu Val Leu Ser Thr Cys Lys Asn Ile Tyr Ser Leu Met Val Glu 
705                 710                 715                 720 


Ala Ser Pro Leu Thr Ile Glu Asp Glu Arg His Ile Thr Ser Val Thr 
                725                 730                 735     


Asn Leu Lys Thr Leu Ser Ile His Asp Leu Gln Asn Gln Arg Leu Pro 
            740                 745                 750         


Gly Gly Leu Thr Asp Ser Leu Gly Asn Leu Lys Asn Leu Thr Lys Leu 
        755                 760                 765             


Ile Met Asp Asn Ile Lys Met Asn Glu Glu Asp Ala Ile Lys Leu Ala 
    770                 775                 780                 


Glu Gly Leu Lys Asn Leu Lys Lys Met Cys Leu Phe His Leu Thr His 
785                 790                 795                 800 


Leu Ser Asp Ile Gly Glu Gly Met Asp Tyr Ile Val Lys Ser Leu Ser 
                805                 810                 815     


Ser Glu Pro Cys Asp Leu Glu Glu Ile Gln Leu Val Ser Cys Cys Leu 
            820                 825                 830         


Ser Ala Asn Ala Val Lys Ile Leu Ala Gln Asn Leu His Asn Leu Val 
        835                 840                 845             


Lys Leu Ser Ile Leu Asp Leu Ser Glu Asn Tyr Leu Glu Lys Asp Gly 
    850                 855                 860                 


Asn Glu Ala Leu His Glu Leu Ile Asp Arg Met Asn Val Leu Glu Gln 
865                 870                 875                 880 


Leu Thr Ala Leu Met Leu Pro Trp Gly Cys Asp Val Gln Gly Ser Leu 
                885                 890                 895     


Ser Ser Leu Leu Lys His Leu Glu Glu Val Pro Gln Leu Val Lys Leu 
            900                 905                 910         


Gly Leu Lys Asn Trp Arg Leu Thr Asp Thr Glu Ile Arg Ile Leu Gly 
        915                 920                 925             


Ala Phe Phe Gly Lys Asn Pro Leu Lys Asn Phe Gln Gln Leu Asn Leu 
    930                 935                 940                 


Ala Gly Asn Arg Val Ser Ser Asp Gly Trp Leu Ala Phe Met Gly Val 
945                 950                 955                 960 


Phe Glu Asn Leu Lys Gln Leu Val Phe Phe Asp Phe Ser Thr Lys Glu 
                965                 970                 975     


Phe Leu Pro Asp Pro Ala Leu Val Arg Lys Leu Ser Gln Val Leu Ser 
            980                 985                 990         


Lys Leu Thr Phe Leu Gln Glu Ala  Arg Leu Val Gly Trp  Gln Phe Asp 
        995                 1000                 1005             


Asp Asp  Asp Leu Ser Val Ile  Thr Gly Ala Phe Lys  Leu Val Thr 
    1010                 1015                 1020             


Ala 
    


<210>  99
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRC4 Isoform 2

<400>  99

Met Asn Phe Ile Lys Asp Asn Ser Arg Ala Leu Ile Gln Arg Met Gly 
1               5                   10                  15      


Met Thr Val Ile Lys Gln Ile Thr Asp Asp Leu Phe Val Trp Asn Val 
            20                  25                  30          


Leu Asn Arg Glu Glu Val Asn Ile Ile Cys Cys Glu Lys Val Glu Gln 
        35                  40                  45              


Asp Ala Ala Arg Gly Ile Ile His Met Ile Leu Lys Lys Gly Ser Glu 
    50                  55                  60                  


Ser Cys Asn Leu Phe Leu Lys Ser Leu Lys Glu Trp Asn Tyr Pro Leu 
65                  70                  75                  80  


Phe Gln Asp Leu Asn Gly Gln Ser Gly Leu Thr Asp Ser Leu Gly Asn 
                85                  90                  95      


Leu Lys Asn Leu Thr Lys Leu Ile Met Asp Asn Ile Lys Met Asn Glu 
            100                 105                 110         


Glu Asp Ala Ile Lys Leu Ala Glu Gly Leu Lys Asn Leu Lys Lys Met 
        115                 120                 125             


Cys Leu Phe His Leu Thr His Leu Ser Asp Ile Gly Glu Gly Met Asp 
    130                 135                 140                 


Tyr Ile Val Lys Ser Leu Ser Ser Glu Pro Cys Asp Leu Glu Glu Ile 
145                 150                 155                 160 


Gln Leu Val Ser Cys Cys Leu Ser Ala Asn Ala Val Lys Ile Leu Ala 
                165                 170                 175     


Gln Asn Leu His Asn Leu Val Lys Leu Ser Ile Leu Asp Leu Ser Glu 
            180                 185                 190         


Asn Tyr Leu Glu Lys Asp Gly Asn Glu Ala Leu His Glu Leu Ile Asp 
        195                 200                 205             


Arg Met Asn Val Leu Glu Gln Leu Thr Ala Leu Met Leu Pro Trp Gly 
    210                 215                 220                 


Cys Asp Val Gln Gly Ser Leu Ser Ser Leu Leu Lys His Leu Glu Glu 
225                 230                 235                 240 


Val Pro Gln Leu Val Lys Leu Gly Leu Lys Asn Trp Arg Leu Thr Asp 
                245                 250                 255     


Thr Glu Ile Arg Ile Leu Gly Ala Phe Phe Gly Lys Asn Pro Leu Lys 
            260                 265                 270         


Asn Phe Gln Gln Leu Asn Leu Ala Gly Asn Arg Val Ser Ser Asp Gly 
        275                 280                 285             


Trp Leu Ala Phe Met Gly Val Phe Glu Asn Leu Lys Gln Leu Val Phe 
    290                 295                 300                 


Phe Asp Phe Ser Thr Lys Glu Phe Leu Pro Asp Pro Ala Leu Val Arg 
305                 310                 315                 320 


Lys Leu Ser Gln Val Leu Ser Lys Leu Thr Phe Leu Gln Glu Ala Arg 
                325                 330                 335     


Leu Val Gly Trp Gln Phe Asp Asp Asp Asp Leu Ser Val Ile Thr Gly 
            340                 345                 350         


Ala Phe Lys Leu Val Thr Ala 
        355                 


<210>  100
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRC4 Isoform 3

<400>  100

Met Asn Phe Ile Lys Asp Asn Ser Arg Ala Leu Ile Gln Arg Met Gly 
1               5                   10                  15      


Met Thr Val Ile Lys Gln Ile Thr Asp Asp Leu Phe Val Trp Asn Val 
            20                  25                  30          


Leu Asn Arg Glu Glu Val Asn Ile Ile Cys Cys Glu Lys Val Glu Gln 
        35                  40                  45              


Asp Ala Ala Arg Gly Ile Ile His Met Ile Leu Lys Lys Gly Ser Glu 
    50                  55                  60                  


Ser Cys Asn Leu Phe Leu Lys Ser Leu Lys Glu Trp Asn Tyr Pro Leu 
65                  70                  75                  80  


Phe Gln Asp Leu Asn Gly Gln Ser Leu Phe His Gln Thr Ser Glu Gly 
                85                  90                  95      


Asp Leu Asp Asp Leu Ala Gln Asp Leu Lys Asp Leu Tyr His Thr Pro 
            100                 105                 110         


Ser Phe Leu Asn Phe Tyr Pro Leu Gly Glu Asp Ile Asp Ile Ile Phe 
        115                 120                 125             


Asn Leu Lys Ser Thr Phe Thr Glu Pro Val Leu Trp Arg Lys Asp Gln 
    130                 135                 140                 


His His His Arg Val Glu Gln Leu Thr Leu Val Leu 
145                 150                 155     


<210>  101
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRC4 Isoform 4

<400>  101

Met Asn Phe Ile Lys Asp Asn Ser Arg Ala Leu Ile Gln Arg Met Gly 
1               5                   10                  15      


Met Thr Val Ile Lys Gln Ile Thr Asp Asp Leu Phe Val Trp Asn Val 
            20                  25                  30          


Leu Asn Arg Glu Glu Val Asn Ile Ile Cys Cys Glu Lys Val Glu Gln 
        35                  40                  45              


Asp Ala Ala Arg Gly Ile Ile His Met Ile Leu Lys Lys Gly Ser Glu 
    50                  55                  60                  


Ser Cys Asn Leu Phe Leu Lys Ser Leu Lys Glu Trp Asn Tyr Pro Leu 
65                  70                  75                  80  


Phe Gln Asp Leu Asn Gly Gln Ser Leu Leu Thr Ala 
                85                  90          


<210>  102
<211>  892
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP6 Isoform 1

<400>  102

Met Asp Gln Pro Glu Ala Pro Cys Ser Ser Thr Gly Pro Arg Leu Ala 
1               5                   10                  15      


Val Ala Arg Glu Leu Leu Leu Ala Ala Leu Glu Glu Leu Ser Gln Glu 
            20                  25                  30          


Gln Leu Lys Arg Phe Arg His Lys Leu Arg Asp Val Gly Pro Asp Gly 
        35                  40                  45              


Arg Ser Ile Pro Trp Gly Arg Leu Glu Arg Ala Asp Ala Val Asp Leu 
    50                  55                  60                  


Ala Glu Gln Leu Ala Gln Phe Tyr Gly Pro Glu Pro Ala Leu Glu Val 
65                  70                  75                  80  


Ala Arg Lys Thr Leu Lys Arg Ala Asp Ala Arg Asp Val Ala Ala Gln 
                85                  90                  95      


Leu Gln Glu Arg Arg Leu Gln Arg Leu Gly Leu Gly Ser Gly Thr Leu 
            100                 105                 110         


Leu Ser Val Ser Glu Tyr Lys Lys Lys Tyr Arg Glu His Val Leu Gln 
        115                 120                 125             


Leu His Ala Arg Val Lys Glu Arg Asn Ala Arg Ser Val Lys Ile Thr 
    130                 135                 140                 


Lys Arg Phe Thr Lys Leu Leu Ile Ala Pro Glu Ser Ala Ala Pro Glu 
145                 150                 155                 160 


Glu Ala Met Gly Pro Ala Glu Glu Pro Glu Pro Gly Arg Ala Arg Arg 
                165                 170                 175     


Ser Asp Thr His Thr Phe Asn Arg Leu Phe Arg Arg Asp Glu Glu Gly 
            180                 185                 190         


Arg Arg Pro Leu Thr Val Val Leu Gln Gly Pro Ala Gly Ile Gly Lys 
        195                 200                 205             


Thr Met Ala Ala Lys Lys Ile Leu Tyr Asp Trp Ala Ala Gly Lys Leu 
    210                 215                 220                 


Tyr Gln Gly Gln Val Asp Phe Ala Phe Phe Met Pro Cys Gly Glu Leu 
225                 230                 235                 240 


Leu Glu Arg Pro Gly Thr Arg Ser Leu Ala Asp Leu Ile Leu Asp Gln 
                245                 250                 255     


Cys Pro Asp Arg Gly Ala Pro Val Pro Gln Met Leu Ala Gln Pro Gln 
            260                 265                 270         


Arg Leu Leu Phe Ile Leu Asp Gly Ala Asp Glu Leu Pro Ala Leu Gly 
        275                 280                 285             


Gly Pro Glu Ala Ala Pro Cys Thr Asp Pro Phe Glu Ala Ala Ser Gly 
    290                 295                 300                 


Ala Arg Val Leu Gly Gly Leu Leu Ser Lys Ala Leu Leu Pro Thr Ala 
305                 310                 315                 320 


Leu Leu Leu Val Thr Thr Arg Ala Ala Ala Pro Gly Arg Leu Gln Gly 
                325                 330                 335     


Arg Leu Cys Ser Pro Gln Cys Ala Glu Val Arg Gly Phe Ser Asp Lys 
            340                 345                 350         


Asp Lys Lys Lys Tyr Phe Tyr Lys Tyr Phe Arg Asp Glu Arg Arg Ala 
        355                 360                 365             


Glu Arg Ala Tyr Arg Phe Val Lys Glu Asn Glu Thr Leu Phe Ala Leu 
    370                 375                 380                 


Cys Phe Val Pro Phe Val Cys Trp Ile Val Cys Thr Val Leu Arg Gln 
385                 390                 395                 400 


Gln Leu Glu Leu Gly Arg Asp Leu Ser Arg Thr Ser Lys Thr Thr Thr 
                405                 410                 415     


Ser Val Tyr Leu Leu Phe Ile Thr Ser Val Leu Ser Ser Ala Pro Val 
            420                 425                 430         


Ala Asp Gly Pro Arg Leu Gln Gly Asp Leu Arg Asn Leu Cys Arg Leu 
        435                 440                 445             


Ala Arg Glu Gly Val Leu Gly Arg Arg Ala Gln Phe Ala Glu Lys Glu 
    450                 455                 460                 


Leu Glu Gln Leu Glu Leu Arg Gly Ser Lys Val Gln Thr Leu Phe Leu 
465                 470                 475                 480 


Ser Lys Lys Glu Leu Pro Gly Val Leu Glu Thr Glu Val Thr Tyr Gln 
                485                 490                 495     


Phe Ile Asp Gln Ser Phe Gln Glu Phe Leu Ala Ala Leu Ser Tyr Leu 
            500                 505                 510         


Leu Glu Asp Gly Gly Val Pro Arg Thr Ala Ala Gly Gly Val Gly Thr 
        515                 520                 525             


Leu Leu Arg Gly Asp Ala Gln Pro His Ser His Leu Val Leu Thr Thr 
    530                 535                 540                 


Arg Phe Leu Phe Gly Leu Leu Ser Ala Glu Arg Met Arg Asp Ile Glu 
545                 550                 555                 560 


Arg His Phe Gly Cys Met Val Ser Glu Arg Val Lys Gln Glu Ala Leu 
                565                 570                 575     


Arg Trp Val Gln Gly Gln Gly Gln Gly Cys Pro Gly Val Ala Pro Glu 
            580                 585                 590         


Val Thr Glu Gly Ala Lys Gly Leu Glu Asp Thr Glu Glu Pro Glu Glu 
        595                 600                 605             


Glu Glu Glu Gly Glu Glu Pro Asn Tyr Pro Leu Glu Leu Leu Tyr Cys 
    610                 615                 620                 


Leu Tyr Glu Thr Gln Glu Asp Ala Phe Val Arg Gln Ala Leu Cys Arg 
625                 630                 635                 640 


Phe Pro Glu Leu Ala Leu Gln Arg Val Arg Phe Cys Arg Met Asp Val 
                645                 650                 655     


Ala Val Leu Ser Tyr Cys Val Arg Cys Cys Pro Ala Gly Gln Ala Leu 
            660                 665                 670         


Arg Leu Ile Ser Cys Arg Leu Val Ala Ala Gln Glu Lys Lys Lys Lys 
        675                 680                 685             


Ser Leu Gly Lys Arg Leu Gln Ala Ser Leu Gly Gly Gly Ser Ser Ser 
    690                 695                 700                 


Gln Gly Thr Thr Lys Gln Leu Pro Ala Ser Leu Leu His Pro Leu Phe 
705                 710                 715                 720 


Gln Ala Met Thr Asp Pro Leu Cys His Leu Ser Ser Leu Thr Leu Ser 
                725                 730                 735     


His Cys Lys Leu Pro Asp Ala Val Cys Arg Asp Leu Ser Glu Ala Leu 
            740                 745                 750         


Arg Ala Ala Pro Ala Leu Thr Glu Leu Gly Leu Leu His Asn Arg Leu 
        755                 760                 765             


Ser Glu Ala Gly Leu Arg Met Leu Ser Glu Gly Leu Ala Trp Pro Gln 
    770                 775                 780                 


Cys Arg Val Gln Thr Val Arg Val Gln Leu Pro Asp Pro Gln Arg Gly 
785                 790                 795                 800 


Leu Gln Tyr Leu Val Gly Met Leu Arg Gln Ser Pro Ala Leu Thr Thr 
                805                 810                 815     


Leu Asp Leu Ser Gly Cys Gln Leu Pro Ala Pro Met Val Thr Tyr Leu 
            820                 825                 830         


Cys Ala Val Leu Gln His Gln Gly Cys Gly Leu Gln Thr Leu Ser Leu 
        835                 840                 845             


Ala Ser Val Glu Leu Ser Glu Gln Ser Leu Gln Glu Leu Gln Ala Val 
    850                 855                 860                 


Lys Arg Ala Lys Pro Asp Leu Val Ile Thr His Pro Ala Leu Asp Gly 
865                 870                 875                 880 


His Pro Gln Pro Pro Lys Glu Leu Ile Ser Thr Phe 
                885                 890         


<210>  103
<211>  891
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP6 Isoform 2

<400>  103

Met Asp Gln Pro Glu Ala Pro Cys Ser Ser Thr Gly Pro Arg Leu Ala 
1               5                   10                  15      


Val Ala Arg Glu Leu Leu Leu Ala Ala Leu Glu Glu Leu Ser Gln Glu 
            20                  25                  30          


Gln Leu Lys Arg Phe Arg His Lys Leu Arg Asp Val Gly Pro Asp Gly 
        35                  40                  45              


Arg Ser Ile Pro Trp Gly Arg Leu Glu Arg Ala Asp Ala Val Asp Leu 
    50                  55                  60                  


Ala Glu Gln Leu Ala Gln Phe Tyr Gly Pro Glu Pro Ala Leu Glu Val 
65                  70                  75                  80  


Ala Arg Lys Thr Leu Lys Arg Ala Asp Ala Arg Asp Val Ala Ala Gln 
                85                  90                  95      


Leu Gln Glu Arg Arg Leu Gln Arg Leu Gly Leu Gly Ser Gly Thr Leu 
            100                 105                 110         


Leu Ser Val Ser Glu Tyr Lys Lys Lys Tyr Arg Glu His Val Leu Gln 
        115                 120                 125             


Leu His Ala Arg Val Lys Glu Arg Asn Ala Arg Ser Val Lys Ile Thr 
    130                 135                 140                 


Lys Arg Phe Thr Lys Leu Leu Ile Ala Pro Glu Ser Ala Ala Pro Glu 
145                 150                 155                 160 


Glu Ala Met Gly Pro Ala Glu Glu Pro Glu Pro Gly Arg Ala Arg Arg 
                165                 170                 175     


Ser Asp Thr His Thr Phe Asn Arg Leu Phe Arg Arg Asp Glu Glu Gly 
            180                 185                 190         


Arg Arg Pro Leu Thr Val Val Leu Gln Gly Pro Ala Gly Ile Gly Lys 
        195                 200                 205             


Thr Met Ala Ala Lys Lys Ile Leu Tyr Asp Trp Ala Ala Gly Lys Leu 
    210                 215                 220                 


Tyr Gln Gly Gln Val Asp Phe Ala Phe Phe Met Pro Cys Gly Glu Leu 
225                 230                 235                 240 


Leu Glu Arg Pro Gly Thr Arg Ser Leu Ala Asp Leu Ile Leu Asp Gln 
                245                 250                 255     


Cys Pro Asp Arg Gly Ala Pro Val Pro Gln Met Leu Ala Gln Pro Gln 
            260                 265                 270         


Arg Leu Leu Phe Ile Leu Asp Gly Ala Asp Glu Leu Pro Ala Leu Gly 
        275                 280                 285             


Gly Pro Glu Ala Ala Pro Cys Thr Asp Pro Phe Glu Ala Ala Ser Gly 
    290                 295                 300                 


Ala Arg Val Leu Gly Gly Leu Leu Ser Lys Ala Leu Leu Pro Thr Ala 
305                 310                 315                 320 


Leu Leu Leu Val Thr Thr Arg Ala Ala Ala Pro Gly Arg Leu Gln Gly 
                325                 330                 335     


Arg Leu Cys Ser Pro Gln Cys Ala Glu Val Arg Gly Phe Ser Asp Lys 
            340                 345                 350         


Asp Lys Lys Lys Tyr Phe Tyr Lys Tyr Phe Arg Asp Glu Arg Arg Ala 
        355                 360                 365             


Glu Arg Ala Tyr Arg Phe Val Lys Glu Asn Glu Thr Leu Phe Ala Leu 
    370                 375                 380                 


Cys Phe Val Pro Phe Val Cys Trp Ile Val Cys Thr Val Leu Arg Gln 
385                 390                 395                 400 


Gln Leu Glu Leu Gly Arg Asp Leu Ser Arg Thr Ser Lys Thr Thr Thr 
                405                 410                 415     


Ser Val Tyr Leu Leu Phe Ile Thr Ser Val Leu Ser Ser Ala Pro Val 
            420                 425                 430         


Ala Asp Gly Pro Arg Leu Gln Gly Asp Leu Arg Asn Leu Cys Arg Leu 
        435                 440                 445             


Ala Arg Glu Gly Val Leu Gly Arg Arg Ala Gln Phe Ala Glu Lys Glu 
    450                 455                 460                 


Leu Glu Gln Leu Glu Leu Arg Gly Ser Lys Val Gln Thr Leu Phe Leu 
465                 470                 475                 480 


Ser Lys Lys Glu Leu Pro Gly Val Leu Glu Thr Glu Val Thr Tyr Gln 
                485                 490                 495     


Phe Ile Asp Gln Ser Phe Gln Glu Phe Leu Ala Ala Leu Ser Tyr Leu 
            500                 505                 510         


Leu Glu Asp Gly Gly Val Pro Arg Thr Ala Ala Gly Gly Val Gly Thr 
        515                 520                 525             


Leu Leu Arg Gly Asp Ala Gln Pro His Ser His Leu Val Leu Thr Thr 
    530                 535                 540                 


Arg Phe Leu Phe Gly Leu Leu Ser Ala Glu Arg Met Arg Asp Ile Glu 
545                 550                 555                 560 


Arg His Phe Gly Cys Met Val Ser Glu Arg Val Lys Gln Glu Ala Leu 
                565                 570                 575     


Arg Trp Val Gln Gly Gln Gly Gln Gly Cys Pro Gly Val Ala Pro Glu 
            580                 585                 590         


Val Thr Glu Gly Ala Lys Gly Leu Glu Asp Thr Glu Glu Pro Glu Glu 
        595                 600                 605             


Glu Glu Glu Gly Glu Glu Pro Asn Tyr Pro Leu Glu Leu Leu Tyr Cys 
    610                 615                 620                 


Leu Tyr Glu Thr Gln Glu Asp Ala Phe Val Arg Gln Ala Leu Cys Arg 
625                 630                 635                 640 


Phe Pro Glu Leu Ala Leu Gln Arg Val Arg Phe Cys Arg Met Asp Val 
                645                 650                 655     


Ala Val Leu Ser Tyr Cys Val Arg Cys Cys Pro Ala Gly Gln Ala Leu 
            660                 665                 670         


Arg Leu Ile Ser Cys Arg Leu Val Ala Ala Gln Glu Lys Lys Lys Lys 
        675                 680                 685             


Ser Leu Gly Lys Arg Leu Gln Ala Ser Leu Gly Gly Gly Ser Ser Gln 
    690                 695                 700                 


Gly Thr Thr Lys Gln Leu Pro Ala Ser Leu Leu His Pro Leu Phe Gln 
705                 710                 715                 720 


Ala Met Thr Asp Pro Leu Cys His Leu Ser Ser Leu Thr Leu Ser His 
                725                 730                 735     


Cys Lys Leu Pro Asp Ala Val Cys Arg Asp Leu Ser Glu Ala Leu Arg 
            740                 745                 750         


Ala Ala Pro Ala Leu Thr Glu Leu Gly Leu Leu His Asn Arg Leu Ser 
        755                 760                 765             


Glu Ala Gly Leu Arg Met Leu Ser Glu Gly Leu Ala Trp Pro Gln Cys 
    770                 775                 780                 


Arg Val Gln Thr Val Arg Val Gln Leu Pro Asp Pro Gln Arg Gly Leu 
785                 790                 795                 800 


Gln Tyr Leu Val Gly Met Leu Arg Gln Ser Pro Ala Leu Thr Thr Leu 
                805                 810                 815     


Asp Leu Ser Gly Cys Gln Leu Pro Ala Pro Met Val Thr Tyr Leu Cys 
            820                 825                 830         


Ala Val Leu Gln His Gln Gly Cys Gly Leu Gln Thr Leu Ser Leu Ala 
        835                 840                 845             


Ser Val Glu Leu Ser Glu Gln Ser Leu Gln Glu Leu Gln Ala Val Lys 
    850                 855                 860                 


Arg Ala Lys Pro Asp Leu Val Ile Thr His Pro Ala Leu Asp Gly His 
865                 870                 875                 880 


Pro Gln Pro Pro Lys Glu Leu Ile Ser Thr Phe 
                885                 890     


<210>  104
<211>  1061
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP12 Isoform 1

<400>  104

Met Leu Arg Thr Ala Gly Arg Asp Gly Leu Cys Arg Leu Ser Thr Tyr 
1               5                   10                  15      


Leu Glu Glu Leu Glu Ala Val Glu Leu Lys Lys Phe Lys Leu Tyr Leu 
            20                  25                  30          


Gly Thr Ala Thr Glu Leu Gly Glu Gly Lys Ile Pro Trp Gly Ser Met 
        35                  40                  45              


Glu Lys Ala Gly Pro Leu Glu Met Ala Gln Leu Leu Ile Thr His Phe 
    50                  55                  60                  


Gly Pro Glu Glu Ala Trp Arg Leu Ala Leu Ser Thr Phe Glu Arg Ile 
65                  70                  75                  80  


Asn Arg Lys Asp Leu Trp Glu Arg Gly Gln Arg Glu Asp Leu Val Arg 
                85                  90                  95      


Asp Thr Pro Pro Gly Gly Pro Ser Ser Leu Gly Asn Gln Ser Thr Cys 
            100                 105                 110         


Leu Leu Glu Val Ser Leu Val Thr Pro Arg Lys Asp Pro Gln Glu Thr 
        115                 120                 125             


Tyr Arg Asp Tyr Val Arg Arg Lys Phe Arg Leu Met Glu Asp Arg Asn 
    130                 135                 140                 


Ala Arg Leu Gly Glu Cys Val Asn Leu Ser His Arg Tyr Thr Arg Leu 
145                 150                 155                 160 


Leu Leu Val Lys Glu His Ser Asn Pro Met Gln Val Gln Gln Gln Leu 
                165                 170                 175     


Leu Asp Thr Gly Arg Gly His Ala Arg Thr Val Gly His Gln Ala Ser 
            180                 185                 190         


Pro Ile Lys Ile Glu Thr Leu Phe Glu Pro Asp Glu Glu Arg Pro Glu 
        195                 200                 205             


Pro Pro Arg Thr Val Val Met Gln Gly Ala Ala Gly Ile Gly Lys Ser 
    210                 215                 220                 


Met Leu Ala His Lys Val Met Leu Asp Trp Ala Asp Gly Lys Leu Phe 
225                 230                 235                 240 


Gln Gly Arg Phe Asp Tyr Leu Phe Tyr Ile Asn Cys Arg Glu Met Asn 
                245                 250                 255     


Gln Ser Ala Thr Glu Cys Ser Met Gln Asp Leu Ile Phe Ser Cys Trp 
            260                 265                 270         


Pro Glu Pro Ser Ala Pro Leu Gln Glu Leu Ile Arg Val Pro Glu Arg 
        275                 280                 285             


Leu Leu Phe Ile Ile Asp Gly Phe Asp Glu Leu Lys Pro Ser Phe His 
    290                 295                 300                 


Asp Pro Gln Gly Pro Trp Cys Leu Cys Trp Glu Glu Lys Arg Pro Thr 
305                 310                 315                 320 


Glu Leu Leu Leu Asn Ser Leu Ile Arg Lys Lys Leu Leu Pro Glu Leu 
                325                 330                 335     


Ser Leu Leu Ile Thr Thr Arg Pro Thr Ala Leu Glu Lys Leu His Arg 
            340                 345                 350         


Leu Leu Glu His Pro Arg His Val Glu Ile Leu Gly Phe Ser Glu Ala 
        355                 360                 365             


Glu Arg Lys Glu Tyr Phe Tyr Lys Tyr Phe His Asn Ala Glu Gln Ala 
    370                 375                 380                 


Gly Gln Val Phe Asn Tyr Val Arg Asp Asn Glu Pro Leu Phe Thr Met 
385                 390                 395                 400 


Cys Phe Val Pro Leu Val Cys Trp Val Val Cys Thr Cys Leu Gln Gln 
                405                 410                 415     


Gln Leu Glu Gly Gly Gly Leu Leu Arg Gln Thr Ser Arg Thr Thr Thr 
            420                 425                 430         


Ala Val Tyr Met Leu Tyr Leu Leu Ser Leu Met Gln Pro Lys Pro Gly 
        435                 440                 445             


Ala Pro Arg Leu Gln Pro Pro Pro Asn Gln Arg Gly Leu Cys Ser Leu 
    450                 455                 460                 


Ala Ala Asp Gly Leu Trp Asn Gln Lys Ile Leu Phe Glu Glu Gln Asp 
465                 470                 475                 480 


Leu Arg Lys His Gly Leu Asp Gly Glu Asp Val Ser Ala Phe Leu Asn 
                485                 490                 495     


Met Asn Ile Phe Gln Lys Asp Ile Asn Cys Glu Arg Tyr Tyr Ser Phe 
            500                 505                 510         


Ile His Leu Ser Phe Gln Glu Phe Phe Ala Ala Met Tyr Tyr Ile Leu 
        515                 520                 525             


Asp Glu Gly Glu Gly Gly Ala Gly Pro Asp Gln Asp Val Thr Arg Leu 
    530                 535                 540                 


Leu Thr Glu Tyr Ala Phe Ser Glu Arg Ser Phe Leu Ala Leu Thr Ser 
545                 550                 555                 560 


Arg Phe Leu Phe Gly Leu Leu Asn Glu Glu Thr Arg Ser His Leu Glu 
                565                 570                 575     


Lys Ser Leu Cys Trp Lys Val Ser Pro His Ile Lys Met Asp Leu Leu 
            580                 585                 590         


Gln Trp Ile Gln Ser Lys Ala Gln Ser Asp Gly Ser Thr Leu Gln Gln 
        595                 600                 605             


Gly Ser Leu Glu Phe Phe Ser Cys Leu Tyr Glu Ile Gln Glu Glu Glu 
    610                 615                 620                 


Phe Ile Gln Gln Ala Leu Ser His Phe Gln Val Ile Val Val Ser Asn 
625                 630                 635                 640 


Ile Ala Ser Lys Met Glu His Met Val Ser Ser Phe Cys Leu Lys Arg 
                645                 650                 655     


Cys Arg Ser Ala Gln Val Leu His Leu Tyr Gly Ala Thr Tyr Ser Ala 
            660                 665                 670         


Asp Gly Glu Asp Arg Ala Arg Cys Ser Ala Gly Ala His Thr Leu Leu 
        675                 680                 685             


Val Gln Leu Pro Glu Arg Thr Val Leu Leu Asp Ala Tyr Ser Glu His 
    690                 695                 700                 


Leu Ala Ala Ala Leu Cys Thr Asn Pro Asn Leu Ile Glu Leu Ser Leu 
705                 710                 715                 720 


Tyr Arg Asn Ala Leu Gly Ser Arg Gly Val Lys Leu Leu Cys Gln Gly 
                725                 730                 735     


Leu Arg His Pro Asn Cys Lys Leu Gln Asn Leu Arg Leu Lys Arg Cys 
            740                 745                 750         


Arg Ile Ser Ser Ser Ala Cys Glu Asp Leu Ser Ala Ala Leu Ile Ala 
        755                 760                 765             


Asn Lys Asn Leu Thr Arg Met Asp Leu Ser Gly Asn Gly Val Gly Phe 
    770                 775                 780                 


Pro Gly Met Met Leu Leu Cys Glu Gly Leu Arg His Pro Gln Cys Arg 
785                 790                 795                 800 


Leu Gln Met Ile Gln Leu Arg Lys Cys Gln Leu Glu Ser Gly Ala Cys 
                805                 810                 815     


Gln Glu Met Ala Ser Val Leu Gly Thr Asn Pro His Leu Val Glu Leu 
            820                 825                 830         


Asp Leu Thr Gly Asn Ala Leu Glu Asp Leu Gly Leu Arg Leu Leu Cys 
        835                 840                 845             


Gln Gly Leu Arg His Pro Val Cys Arg Leu Arg Thr Leu Trp Leu Lys 
    850                 855                 860                 


Ile Cys Arg Leu Thr Ala Ala Ala Cys Asp Glu Leu Ala Ser Thr Leu 
865                 870                 875                 880 


Ser Val Asn Gln Ser Leu Arg Glu Leu Asp Leu Ser Leu Asn Glu Leu 
                885                 890                 895     


Gly Asp Leu Gly Val Leu Leu Leu Cys Glu Gly Leu Arg His Pro Thr 
            900                 905                 910         


Cys Lys Leu Gln Thr Leu Arg Leu Gly Ile Cys Arg Leu Gly Ser Ala 
        915                 920                 925             


Ala Cys Glu Gly Leu Ser Val Val Leu Gln Ala Asn His Asn Leu Arg 
    930                 935                 940                 


Glu Leu Asp Leu Ser Phe Asn Asp Leu Gly Asp Trp Gly Leu Trp Leu 
945                 950                 955                 960 


Leu Ala Glu Gly Leu Gln His Pro Ala Cys Arg Leu Gln Lys Leu Trp 
                965                 970                 975     


Leu Asp Ser Cys Gly Leu Thr Ala Lys Ala Cys Glu Asn Leu Tyr Phe 
            980                 985                 990         


Thr Leu Gly Ile Asn Gln Thr Leu  Thr Asp Leu Tyr Leu  Thr Asn Asn 
        995                 1000                 1005             


Ala Leu  Gly Asp Thr Gly Val  Arg Leu Leu Cys Lys  Arg Leu Ser 
    1010                 1015                 1020             


His Pro  Gly Cys Lys Leu Arg  Val Leu Trp Leu Phe  Gly Met Asp 
    1025                 1030                 1035             


Leu Asn  Lys Met Thr His Ser  Arg Leu Ala Ala Leu  Arg Val Thr 
    1040                 1045                 1050             


Lys Pro  Tyr Leu Asp Ile Gly  Cys 
    1055                 1060     


<210>  105
<211>  1005
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP12 Isoform 2

<400>  105

Met Leu Arg Thr Ala Gly Arg Asp Gly Leu Cys Arg Leu Ser Thr Tyr 
1               5                   10                  15      


Leu Glu Glu Leu Glu Ala Val Glu Leu Lys Lys Phe Lys Leu Tyr Leu 
            20                  25                  30          


Gly Thr Ala Thr Glu Leu Gly Glu Gly Lys Ile Pro Trp Gly Ser Met 
        35                  40                  45              


Glu Lys Ala Gly Pro Leu Glu Met Ala Gln Leu Leu Ile Thr His Phe 
    50                  55                  60                  


Gly Pro Glu Glu Ala Trp Arg Leu Ala Leu Ser Thr Phe Glu Arg Ile 
65                  70                  75                  80  


Asn Arg Lys Asp Leu Trp Glu Arg Gly Gln Arg Glu Asp Leu Val Arg 
                85                  90                  95      


Asp Thr Pro Pro Gly Gly Pro Ser Ser Leu Gly Asn Gln Ser Thr Cys 
            100                 105                 110         


Leu Leu Glu Val Ser Leu Val Thr Pro Arg Lys Asp Pro Gln Glu Thr 
        115                 120                 125             


Tyr Arg Asp Tyr Val Arg Arg Lys Phe Arg Leu Met Glu Asp Arg Asn 
    130                 135                 140                 


Ala Arg Leu Gly Glu Cys Val Asn Leu Ser His Arg Tyr Thr Arg Leu 
145                 150                 155                 160 


Leu Leu Val Lys Glu His Ser Asn Pro Met Gln Val Gln Gln Gln Leu 
                165                 170                 175     


Leu Asp Thr Gly Arg Gly His Ala Arg Thr Val Gly His Gln Ala Ser 
            180                 185                 190         


Pro Ile Lys Ile Glu Thr Leu Phe Glu Pro Asp Glu Glu Arg Pro Glu 
        195                 200                 205             


Pro Pro Arg Thr Val Val Met Gln Gly Ala Ala Gly Ile Gly Lys Ser 
    210                 215                 220                 


Met Leu Ala His Lys Val Met Leu Asp Trp Ala Asp Gly Lys Leu Phe 
225                 230                 235                 240 


Gln Gly Arg Phe Asp Tyr Leu Phe Tyr Ile Asn Cys Arg Glu Met Asn 
                245                 250                 255     


Gln Ser Ala Thr Glu Cys Ser Met Gln Asp Leu Ile Phe Ser Cys Trp 
            260                 265                 270         


Pro Glu Pro Ser Ala Pro Leu Gln Glu Leu Ile Arg Val Pro Glu Arg 
        275                 280                 285             


Leu Leu Phe Ile Ile Asp Gly Phe Asp Glu Leu Lys Pro Ser Phe His 
    290                 295                 300                 


Asp Pro Gln Gly Pro Trp Cys Leu Cys Trp Glu Glu Lys Arg Pro Thr 
305                 310                 315                 320 


Glu Leu Leu Leu Asn Ser Leu Ile Arg Lys Lys Leu Leu Pro Glu Leu 
                325                 330                 335     


Ser Leu Leu Ile Thr Thr Arg Pro Thr Ala Leu Glu Lys Leu His Arg 
            340                 345                 350         


Leu Leu Glu His Pro Arg His Val Glu Ile Leu Gly Phe Ser Glu Ala 
        355                 360                 365             


Glu Arg Lys Glu Tyr Phe Tyr Lys Tyr Phe His Asn Ala Glu Gln Ala 
    370                 375                 380                 


Gly Gln Val Phe Asn Tyr Val Arg Asp Asn Glu Pro Leu Phe Thr Met 
385                 390                 395                 400 


Cys Phe Val Pro Leu Val Cys Trp Val Val Cys Thr Cys Leu Gln Gln 
                405                 410                 415     


Gln Leu Glu Gly Gly Gly Leu Leu Arg Gln Thr Ser Arg Thr Thr Thr 
            420                 425                 430         


Ala Val Tyr Met Leu Tyr Leu Leu Ser Leu Met Gln Pro Lys Pro Gly 
        435                 440                 445             


Ala Pro Arg Leu Gln Pro Pro Pro Asn Gln Arg Gly Leu Cys Ser Leu 
    450                 455                 460                 


Ala Ala Asp Gly Leu Trp Asn Gln Lys Ile Leu Phe Glu Glu Gln Asp 
465                 470                 475                 480 


Leu Arg Lys His Gly Leu Asp Gly Glu Asp Val Ser Ala Phe Leu Asn 
                485                 490                 495     


Met Asn Ile Phe Gln Lys Asp Ile Asn Cys Glu Arg Tyr Tyr Ser Phe 
            500                 505                 510         


Ile His Leu Ser Phe Gln Glu Phe Phe Ala Ala Met Tyr Tyr Ile Leu 
        515                 520                 525             


Asp Glu Gly Glu Gly Gly Ala Gly Pro Asp Gln Asp Val Thr Arg Leu 
    530                 535                 540                 


Leu Thr Glu Tyr Ala Phe Ser Glu Arg Ser Phe Leu Ala Leu Thr Ser 
545                 550                 555                 560 


Arg Phe Leu Phe Gly Leu Leu Asn Glu Glu Thr Arg Ser His Leu Glu 
                565                 570                 575     


Lys Ser Leu Cys Trp Lys Val Ser Pro His Ile Lys Met Asp Leu Leu 
            580                 585                 590         


Gln Trp Ile Gln Ser Lys Ala Gln Ser Asp Gly Ser Thr Leu Gln Gln 
        595                 600                 605             


Gly Ser Leu Glu Phe Phe Ser Cys Leu Tyr Glu Ile Gln Glu Glu Glu 
    610                 615                 620                 


Phe Ile Gln Gln Ala Leu Ser His Phe Gln Val Ile Val Val Ser Asn 
625                 630                 635                 640 


Ile Ala Ser Lys Met Glu His Met Val Ser Ser Phe Cys Leu Lys Arg 
                645                 650                 655     


Cys Arg Ser Ala Gln Val Leu His Leu Tyr Gly Ala Thr Tyr Ser Ala 
            660                 665                 670         


Asp Gly Glu Asp Arg Ala Arg Cys Ser Ala Gly Ala His Thr Leu Leu 
        675                 680                 685             


Val Gln Leu Pro Glu Arg Thr Val Leu Leu Asp Ala Tyr Ser Glu His 
    690                 695                 700                 


Leu Ala Ala Ala Leu Cys Thr Asn Pro Asn Leu Ile Glu Leu Ser Leu 
705                 710                 715                 720 


Tyr Arg Asn Ala Leu Gly Ser Arg Gly Val Lys Leu Leu Cys Gln Gly 
                725                 730                 735     


Leu Arg His Pro Asn Cys Lys Leu Gln Asn Leu Arg Leu Lys Arg Cys 
            740                 745                 750         


Arg Ile Ser Ser Ser Ala Cys Glu Asp Leu Ser Ala Ala Leu Ile Ala 
        755                 760                 765             


Asn Lys Asn Leu Thr Arg Met Asp Leu Ser Gly Asn Gly Val Gly Phe 
    770                 775                 780                 


Pro Gly Met Met Leu Leu Cys Glu Gly Leu Arg His Pro Gln Cys Arg 
785                 790                 795                 800 


Leu Gln Met Ile Gln Leu Arg Lys Cys Gln Leu Glu Ser Gly Ala Cys 
                805                 810                 815     


Gln Glu Met Ala Ser Val Leu Gly Thr Asn Pro His Leu Val Glu Leu 
            820                 825                 830         


Asp Leu Thr Gly Asn Ala Leu Glu Asp Leu Gly Leu Arg Leu Leu Cys 
        835                 840                 845             


Gln Gly Leu Arg His Pro Val Cys Arg Leu Arg Thr Leu Trp Leu Lys 
    850                 855                 860                 


Ile Cys Arg Leu Thr Ala Ala Ala Cys Asp Glu Leu Ala Ser Thr Leu 
865                 870                 875                 880 


Ser Val Asn Gln Ser Leu Arg Glu Leu Asp Leu Ser Leu Asn Glu Leu 
                885                 890                 895     


Gly Asp Leu Gly Val Leu Leu Leu Cys Glu Gly Leu Arg His Pro Thr 
            900                 905                 910         


Cys Lys Leu Gln Thr Leu Arg Leu Gly Ile Cys Arg Leu Gly Ser Ala 
        915                 920                 925             


Ala Cys Glu Gly Leu Ser Val Val Leu Gln Ala Asn His Asn Leu Arg 
    930                 935                 940                 


Glu Leu Asp Leu Ser Phe Asn Asp Leu Gly Asp Trp Gly Leu Trp Leu 
945                 950                 955                 960 


Leu Ala Glu Gly Leu Gln His Pro Ala Cys Arg Leu Gln Lys Leu Leu 
                965                 970                 975     


Trp Leu Phe Gly Met Asp Leu Asn Lys Met Thr His Ser Arg Leu Ala 
            980                 985                 990         


Ala Leu Arg Val Thr Lys Pro Tyr  Leu Asp Ile Gly Cys  
        995                 1000                 1005 


<210>  106
<211>  949
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP12 Isoform 3

<400>  106

Met Leu Arg Thr Ala Gly Arg Asp Gly Leu Cys Arg Leu Ser Thr Tyr 
1               5                   10                  15      


Leu Glu Glu Leu Glu Ala Val Glu Leu Lys Lys Phe Lys Leu Tyr Leu 
            20                  25                  30          


Gly Thr Ala Thr Glu Leu Gly Glu Gly Lys Ile Pro Trp Gly Ser Met 
        35                  40                  45              


Glu Lys Ala Gly Pro Leu Glu Met Ala Gln Leu Leu Ile Thr His Phe 
    50                  55                  60                  


Gly Pro Glu Glu Ala Trp Arg Leu Ala Leu Ser Thr Phe Glu Arg Ile 
65                  70                  75                  80  


Asn Arg Lys Asp Leu Trp Glu Arg Gly Gln Arg Glu Asp Leu Val Arg 
                85                  90                  95      


Asp Thr Pro Pro Gly Gly Pro Ser Ser Leu Gly Asn Gln Ser Thr Cys 
            100                 105                 110         


Leu Leu Glu Val Ser Leu Val Thr Pro Arg Lys Asp Pro Gln Glu Thr 
        115                 120                 125             


Tyr Arg Asp Tyr Val Arg Arg Lys Phe Arg Leu Met Glu Asp Arg Asn 
    130                 135                 140                 


Ala Arg Leu Gly Glu Cys Val Asn Leu Ser His Arg Tyr Thr Arg Leu 
145                 150                 155                 160 


Leu Leu Val Lys Glu His Ser Asn Pro Met Gln Val Gln Gln Gln Leu 
                165                 170                 175     


Leu Asp Thr Gly Arg Gly His Ala Arg Thr Val Gly His Gln Ala Ser 
            180                 185                 190         


Pro Ile Lys Ile Glu Thr Leu Phe Glu Pro Asp Glu Glu Arg Pro Glu 
        195                 200                 205             


Pro Pro Arg Thr Val Val Met Gln Gly Ala Ala Gly Ile Gly Lys Ser 
    210                 215                 220                 


Met Leu Ala His Lys Val Met Leu Asp Trp Ala Asp Gly Lys Leu Phe 
225                 230                 235                 240 


Gln Gly Arg Phe Asp Tyr Leu Phe Tyr Ile Asn Cys Arg Glu Met Asn 
                245                 250                 255     


Gln Ser Ala Thr Glu Cys Ser Met Gln Asp Leu Ile Phe Ser Cys Trp 
            260                 265                 270         


Pro Glu Pro Ser Ala Pro Leu Gln Glu Leu Ile Arg Val Pro Glu Arg 
        275                 280                 285             


Leu Leu Phe Ile Ile Asp Gly Phe Asp Glu Leu Lys Pro Ser Phe His 
    290                 295                 300                 


Asp Pro Gln Gly Pro Trp Cys Leu Cys Trp Glu Glu Lys Arg Pro Thr 
305                 310                 315                 320 


Glu Leu Leu Leu Asn Ser Leu Ile Arg Lys Lys Leu Leu Pro Glu Leu 
                325                 330                 335     


Ser Leu Leu Ile Thr Thr Arg Pro Thr Ala Leu Glu Lys Leu His Arg 
            340                 345                 350         


Leu Leu Glu His Pro Arg His Val Glu Ile Leu Gly Phe Ser Glu Ala 
        355                 360                 365             


Glu Arg Lys Glu Tyr Phe Tyr Lys Tyr Phe His Asn Ala Glu Gln Ala 
    370                 375                 380                 


Gly Gln Val Phe Asn Tyr Val Arg Asp Asn Glu Pro Leu Phe Thr Met 
385                 390                 395                 400 


Cys Phe Val Pro Leu Val Cys Trp Val Val Cys Thr Cys Leu Gln Gln 
                405                 410                 415     


Gln Leu Glu Gly Gly Gly Leu Leu Arg Gln Thr Ser Arg Thr Thr Thr 
            420                 425                 430         


Ala Val Tyr Met Leu Tyr Leu Leu Ser Leu Met Gln Pro Lys Pro Gly 
        435                 440                 445             


Ala Pro Arg Leu Gln Pro Pro Pro Asn Gln Arg Gly Leu Cys Ser Leu 
    450                 455                 460                 


Ala Ala Asp Gly Leu Trp Asn Gln Lys Ile Leu Phe Glu Glu Gln Asp 
465                 470                 475                 480 


Leu Arg Lys His Gly Leu Asp Gly Glu Asp Val Ser Ala Phe Leu Asn 
                485                 490                 495     


Met Asn Ile Phe Gln Lys Asp Ile Asn Cys Glu Arg Tyr Tyr Ser Phe 
            500                 505                 510         


Ile His Leu Ser Phe Gln Glu Phe Phe Ala Ala Met Tyr Tyr Ile Leu 
        515                 520                 525             


Asp Glu Gly Glu Gly Gly Ala Gly Pro Asp Gln Asp Val Thr Arg Leu 
    530                 535                 540                 


Leu Thr Glu Tyr Ala Phe Ser Glu Arg Ser Phe Leu Ala Leu Thr Ser 
545                 550                 555                 560 


Arg Phe Leu Phe Gly Leu Leu Asn Glu Glu Thr Arg Ser His Leu Glu 
                565                 570                 575     


Lys Ser Leu Cys Trp Lys Val Ser Pro His Ile Lys Met Asp Leu Leu 
            580                 585                 590         


Gln Trp Ile Gln Ser Lys Ala Gln Ser Asp Gly Ser Thr Leu Gln Gln 
        595                 600                 605             


Gly Ser Leu Glu Phe Phe Ser Cys Leu Tyr Glu Ile Gln Glu Glu Glu 
    610                 615                 620                 


Phe Ile Gln Gln Ala Leu Ser His Phe Gln Val Ile Val Val Ser Asn 
625                 630                 635                 640 


Ile Ala Ser Lys Met Glu His Met Val Ser Ser Phe Cys Leu Lys Arg 
                645                 650                 655     


Cys Arg Ser Ala Gln Val Leu His Leu Tyr Gly Ala Thr Tyr Ser Ala 
            660                 665                 670         


Asp Gly Glu Asp Arg Ala Arg Cys Ser Ala Gly Ala His Thr Leu Leu 
        675                 680                 685             


Val Gln Leu Pro Glu Arg Thr Val Leu Leu Asp Ala Tyr Ser Glu His 
    690                 695                 700                 


Leu Ala Ala Ala Leu Cys Thr Asn Pro Asn Leu Ile Glu Leu Ser Leu 
705                 710                 715                 720 


Tyr Arg Asn Ala Leu Gly Ser Arg Gly Val Lys Leu Leu Cys Gln Gly 
                725                 730                 735     


Leu Arg His Pro Asn Cys Lys Leu Gln Asn Leu Arg Leu Lys Arg Cys 
            740                 745                 750         


Arg Ile Ser Ser Ser Ala Cys Glu Asp Leu Ser Ala Ala Leu Ile Ala 
        755                 760                 765             


Asn Lys Asn Leu Thr Arg Met Asp Leu Ser Gly Asn Gly Val Gly Phe 
    770                 775                 780                 


Pro Gly Met Met Leu Leu Cys Glu Gly Leu Arg His Pro Gln Cys Arg 
785                 790                 795                 800 


Leu Gln Met Ile Gln Leu Arg Lys Cys Gln Leu Glu Ser Gly Ala Cys 
                805                 810                 815     


Gln Glu Met Ala Ser Val Leu Gly Thr Asn Pro His Leu Val Glu Leu 
            820                 825                 830         


Asp Leu Thr Gly Asn Ala Leu Glu Asp Leu Gly Leu Arg Leu Leu Cys 
        835                 840                 845             


Gln Gly Leu Arg His Pro Val Cys Arg Leu Arg Thr Leu Lys Leu Trp 
    850                 855                 860                 


Leu Asp Ser Cys Gly Leu Thr Ala Lys Ala Cys Glu Asn Leu Tyr Phe 
865                 870                 875                 880 


Thr Leu Gly Ile Asn Gln Thr Leu Thr Asp Leu Tyr Leu Thr Asn Asn 
                885                 890                 895     


Ala Leu Gly Asp Thr Gly Val Arg Leu Leu Cys Lys Arg Leu Ser His 
            900                 905                 910         


Pro Gly Cys Lys Leu Arg Val Leu Trp Leu Phe Gly Met Asp Leu Asn 
        915                 920                 925             


Lys Met Thr His Ser Arg Leu Ala Ala Leu Arg Val Thr Lys Pro Tyr 
    930                 935                 940                 


Leu Asp Ile Gly Cys 
945                 


<210>  107
<211>  891
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP12 Isoform 4

<400>  107

Met Leu Arg Thr Ala Gly Arg Asp Gly Leu Cys Arg Leu Ser Thr Tyr 
1               5                   10                  15      


Leu Glu Glu Leu Glu Ala Val Glu Leu Lys Lys Phe Lys Leu Tyr Leu 
            20                  25                  30          


Gly Thr Ala Thr Glu Leu Gly Glu Gly Lys Ile Pro Trp Gly Ser Met 
        35                  40                  45              


Glu Lys Ala Gly Pro Leu Glu Met Ala Gln Leu Leu Ile Thr His Phe 
    50                  55                  60                  


Gly Pro Glu Glu Ala Trp Arg Leu Ala Leu Ser Thr Phe Glu Arg Ile 
65                  70                  75                  80  


Asn Arg Lys Asp Leu Trp Glu Arg Gly Gln Arg Glu Asp Leu Val Arg 
                85                  90                  95      


Asp Thr Pro Pro Gly Gly Pro Ser Ser Leu Gly Asn Gln Ser Thr Cys 
            100                 105                 110         


Leu Leu Glu Val Ser Leu Val Thr Pro Arg Lys Asp Pro Gln Glu Thr 
        115                 120                 125             


Tyr Arg Asp Tyr Val Arg Arg Lys Phe Arg Leu Met Glu Asp Arg Asn 
    130                 135                 140                 


Ala Arg Leu Gly Glu Cys Val Asn Leu Ser His Arg Tyr Thr Arg Leu 
145                 150                 155                 160 


Leu Leu Val Lys Glu His Ser Asn Pro Met Gln Val Gln Gln Gln Leu 
                165                 170                 175     


Leu Asp Thr Gly Arg Gly His Ala Arg Thr Val Gly His Gln Ala Ser 
            180                 185                 190         


Pro Ile Lys Ile Glu Thr Leu Phe Glu Pro Asp Glu Glu Arg Pro Glu 
        195                 200                 205             


Pro Pro Arg Thr Val Val Met Gln Gly Ala Ala Gly Ile Gly Lys Ser 
    210                 215                 220                 


Met Leu Ala His Lys Val Met Leu Asp Trp Ala Asp Gly Lys Leu Phe 
225                 230                 235                 240 


Gln Gly Arg Phe Asp Tyr Leu Phe Tyr Ile Asn Cys Arg Glu Met Asn 
                245                 250                 255     


Gln Ser Ala Thr Glu Cys Ser Met Gln Asp Leu Ile Phe Ser Cys Trp 
            260                 265                 270         


Pro Glu Pro Ser Ala Pro Leu Gln Glu Leu Ile Arg Val Pro Glu Arg 
        275                 280                 285             


Leu Leu Phe Ile Ile Asp Gly Phe Asp Glu Leu Lys Pro Ser Phe His 
    290                 295                 300                 


Asp Pro Gln Gly Pro Trp Cys Leu Cys Trp Glu Glu Lys Arg Pro Thr 
305                 310                 315                 320 


Glu Leu Leu Leu Asn Ser Leu Ile Arg Lys Lys Leu Leu Pro Glu Leu 
                325                 330                 335     


Ser Leu Leu Ile Thr Thr Arg Pro Thr Ala Leu Glu Lys Leu His Arg 
            340                 345                 350         


Leu Leu Glu His Pro Arg His Val Glu Ile Leu Gly Phe Ser Glu Ala 
        355                 360                 365             


Glu Arg Lys Glu Tyr Phe Tyr Lys Tyr Phe His Asn Ala Glu Gln Ala 
    370                 375                 380                 


Gly Gln Val Phe Asn Tyr Val Arg Asp Asn Glu Pro Leu Phe Thr Met 
385                 390                 395                 400 


Cys Phe Val Pro Leu Val Cys Trp Val Val Cys Thr Cys Leu Gln Gln 
                405                 410                 415     


Gln Leu Glu Gly Gly Gly Leu Leu Arg Gln Thr Ser Arg Thr Thr Thr 
            420                 425                 430         


Ala Val Tyr Met Leu Tyr Leu Leu Ser Leu Met Gln Pro Lys Pro Gly 
        435                 440                 445             


Ala Pro Arg Leu Gln Pro Pro Pro Asn Gln Arg Gly Leu Cys Ser Leu 
    450                 455                 460                 


Ala Ala Asp Gly Leu Trp Asn Gln Lys Ile Leu Phe Glu Glu Gln Asp 
465                 470                 475                 480 


Leu Arg Lys His Gly Leu Asp Gly Glu Asp Val Ser Ala Phe Leu Asn 
                485                 490                 495     


Met Asn Ile Phe Gln Lys Asp Ile Asn Cys Glu Arg Tyr Tyr Ser Phe 
            500                 505                 510         


Ile His Leu Ser Phe Gln Glu Phe Phe Ala Ala Met Tyr Tyr Ile Leu 
        515                 520                 525             


Asp Glu Gly Glu Gly Gly Ala Gly Pro Asp Gln Asp Val Thr Arg Leu 
    530                 535                 540                 


Leu Thr Glu Tyr Ala Phe Ser Glu Arg Ser Phe Leu Ala Leu Thr Ser 
545                 550                 555                 560 


Arg Phe Leu Phe Gly Leu Leu Asn Glu Glu Thr Arg Ser His Leu Glu 
                565                 570                 575     


Lys Ser Leu Cys Trp Lys Val Ser Pro His Ile Lys Met Asp Leu Leu 
            580                 585                 590         


Gln Trp Ile Gln Ser Lys Ala Gln Ser Asp Gly Ser Thr Leu Gln Gln 
        595                 600                 605             


Gly Ser Leu Glu Phe Phe Ser Cys Leu Tyr Glu Ile Gln Glu Glu Glu 
    610                 615                 620                 


Phe Ile Gln Gln Ala Leu Ser His Phe Gln Val Ile Val Val Ser Asn 
625                 630                 635                 640 


Ile Ala Ser Lys Met Glu His Met Val Ser Ser Phe Cys Leu Lys Arg 
                645                 650                 655     


Cys Arg Ser Ala Gln Val Leu His Leu Tyr Gly Ala Thr Tyr Ser Ala 
            660                 665                 670         


Asp Gly Glu Asp Arg Ala Arg Cys Ser Ala Gly Ala His Thr Leu Leu 
        675                 680                 685             


Val Gln Leu Pro Glu Arg Thr Val Leu Leu Asp Ala Tyr Ser Glu His 
    690                 695                 700                 


Leu Ala Ala Ala Leu Cys Thr Asn Pro Asn Leu Ile Glu Leu Ser Leu 
705                 710                 715                 720 


Tyr Arg Asn Ala Leu Gly Ser Arg Gly Val Lys Leu Leu Cys Gln Gly 
                725                 730                 735     


Leu Arg His Pro Asn Cys Lys Leu Gln Asn Leu Arg Leu Lys Arg Cys 
            740                 745                 750         


Arg Ile Ser Ser Ser Ala Cys Glu Asp Leu Ser Ala Ala Leu Ile Ala 
        755                 760                 765             


Asn Lys Asn Leu Thr Arg Met Asp Leu Ser Gly Asn Gly Val Gly Phe 
    770                 775                 780                 


Pro Gly Met Met Leu Leu Cys Glu Gly Leu Arg His Pro Gln Cys Arg 
785                 790                 795                 800 


Leu Gln Met Ile Gln Leu Arg Lys Cys Gln Leu Glu Ser Gly Ala Cys 
                805                 810                 815     


Gln Glu Met Ala Ser Val Leu Gly Thr Asn Pro His Leu Val Glu Leu 
            820                 825                 830         


Asp Leu Thr Gly Asn Ala Leu Glu Asp Leu Gly Leu Arg Leu Leu Cys 
        835                 840                 845             


Gln Gly Leu Arg His Pro Val Cys Arg Leu Arg Thr Leu Leu Trp Leu 
    850                 855                 860                 


Phe Gly Met Asp Leu Asn Lys Met Thr His Ser Arg Leu Ala Ala Leu 
865                 870                 875                 880 


Arg Val Thr Lys Pro Tyr Leu Asp Ile Gly Cys 
                885                 890     


<210>  108
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP12 Isoform 5

<400>  108

Met Ser Gln Ala Trp Trp His Thr Ser Val Ser Pro Ala Thr Gln Glu 
1               5                   10                  15      


Ala Lys Ala Gly Gly Leu Leu Gln Pro Arg Arg Gln Arg Leu Trp Leu 
            20                  25                  30          


Lys Arg Cys Arg Ile Ser Ser Ser Ala Cys Glu Asp Leu Ser Ala Ala 
        35                  40                  45              


Leu Ile Ala Asn Lys Asn Leu Thr Arg Met Asp Leu Ser Gly Asn Gly 
    50                  55                  60                  


Val Gly Phe Pro Gly Met Met Leu Leu Cys Glu Gly Leu Arg His Pro 
65                  70                  75                  80  


Gln Cys Arg Leu Gln Met Ile Gln Leu Arg Lys Cys Gln Leu Glu Ser 
                85                  90                  95      


Gly Ala Cys Gln Glu Met Ala Ser Val Leu Gly Thr Asn Pro His Leu 
            100                 105                 110         


Val Glu Leu Asp Leu Thr Gly Asn Ala Leu Glu Asp Leu Gly Leu Arg 
        115                 120                 125             


Leu Leu Cys Gln Gly Leu Arg His Pro Val Cys Arg Leu Arg Thr Leu 
    130                 135                 140                 


Trp Leu Lys Ile Cys Arg Leu Thr Ala Ala Ala Cys Asp Glu Leu Ala 
145                 150                 155                 160 


Ser Thr Leu Ser Val Asn Gln Ser Leu Arg Glu Leu Asp Leu Ser Leu 
                165                 170                 175     


Asn Glu Leu Gly Asp Leu Gly Val Leu Leu Leu Cys Glu Gly Leu Arg 
            180                 185                 190         


His Pro Thr Cys Lys Leu Gln Thr Leu Arg Leu Asp Ser Cys Gly Leu 
        195                 200                 205             


Thr Ala Lys Ala Cys Glu Asn Leu Tyr Phe Thr Leu Gly Ile Asn Gln 
    210                 215                 220                 


Thr Leu Thr Asp Leu Tyr Leu Thr Asn Asn Ala Leu Gly Asp Thr Gly 
225                 230                 235                 240 


Val Arg Leu Leu Cys Lys Arg Leu Ser His Pro Gly Cys Lys Leu Arg 
                245                 250                 255     


Val Leu Trp Leu Phe Gly Met Asp Leu Asn Lys Met Thr His Ser Arg 
            260                 265                 270         


Leu Ala Ala Leu Arg Val Thr Lys Pro Tyr Leu Asp Ile Gly Cys 
        275                 280                 285         


<210>  109
<211>  1004
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP12 Isoform 6

<400>  109

Met Leu Arg Thr Ala Gly Arg Asp Gly Leu Cys Arg Leu Ser Thr Tyr 
1               5                   10                  15      


Leu Glu Glu Leu Glu Ala Val Glu Leu Lys Lys Phe Lys Leu Tyr Leu 
            20                  25                  30          


Gly Thr Ala Thr Glu Leu Gly Glu Gly Lys Ile Pro Trp Gly Ser Met 
        35                  40                  45              


Glu Lys Ala Gly Pro Leu Glu Met Ala Gln Leu Leu Ile Thr His Phe 
    50                  55                  60                  


Gly Pro Glu Glu Ala Trp Arg Leu Ala Leu Ser Thr Phe Glu Arg Ile 
65                  70                  75                  80  


Asn Arg Lys Asp Leu Trp Glu Arg Gly Gln Arg Glu Asp Leu Val Arg 
                85                  90                  95      


Asp Thr Pro Pro Gly Gly Pro Ser Ser Leu Gly Asn Gln Ser Thr Cys 
            100                 105                 110         


Leu Leu Glu Val Ser Leu Val Thr Pro Arg Lys Asp Pro Gln Glu Thr 
        115                 120                 125             


Tyr Arg Asp Tyr Val Arg Arg Lys Phe Arg Leu Met Glu Asp Arg Asn 
    130                 135                 140                 


Ala Arg Leu Gly Glu Cys Val Asn Leu Ser His Arg Tyr Thr Arg Leu 
145                 150                 155                 160 


Leu Leu Val Lys Glu His Ser Asn Pro Met Gln Val Gln Gln Gln Leu 
                165                 170                 175     


Leu Asp Thr Gly Arg Gly His Ala Arg Thr Val Gly His Gln Ala Ser 
            180                 185                 190         


Pro Ile Lys Ile Glu Thr Leu Phe Glu Pro Asp Glu Glu Arg Pro Glu 
        195                 200                 205             


Pro Pro Arg Thr Val Val Met Gln Gly Ala Ala Gly Ile Gly Lys Ser 
    210                 215                 220                 


Met Leu Ala His Lys Val Met Leu Asp Trp Ala Asp Gly Lys Leu Phe 
225                 230                 235                 240 


Gln Gly Arg Phe Asp Tyr Leu Phe Tyr Ile Asn Cys Arg Glu Met Asn 
                245                 250                 255     


Gln Ser Ala Thr Glu Cys Ser Met Gln Asp Leu Ile Phe Ser Cys Trp 
            260                 265                 270         


Pro Glu Pro Ser Ala Pro Leu Gln Glu Leu Ile Arg Val Pro Glu Arg 
        275                 280                 285             


Leu Leu Phe Ile Ile Asp Gly Phe Asp Glu Leu Lys Pro Ser Phe His 
    290                 295                 300                 


Asp Pro Gln Gly Pro Trp Cys Leu Cys Trp Glu Glu Lys Arg Pro Thr 
305                 310                 315                 320 


Glu Leu Leu Leu Asn Ser Leu Ile Arg Lys Lys Leu Leu Pro Glu Leu 
                325                 330                 335     


Ser Leu Leu Ile Thr Thr Arg Pro Thr Ala Leu Glu Lys Leu His Arg 
            340                 345                 350         


Leu Leu Glu His Pro Arg His Val Glu Ile Leu Gly Phe Ser Glu Ala 
        355                 360                 365             


Glu Arg Lys Glu Tyr Phe Tyr Lys Tyr Phe His Asn Ala Glu Gln Ala 
    370                 375                 380                 


Gly Gln Val Phe Asn Tyr Val Arg Asp Asn Glu Pro Leu Phe Thr Met 
385                 390                 395                 400 


Cys Phe Val Pro Leu Val Cys Trp Val Val Cys Thr Cys Leu Gln Gln 
                405                 410                 415     


Gln Leu Glu Gly Gly Gly Leu Leu Arg Gln Thr Ser Arg Thr Thr Thr 
            420                 425                 430         


Ala Val Tyr Met Leu Tyr Leu Leu Ser Leu Met Gln Pro Lys Pro Gly 
        435                 440                 445             


Ala Pro Arg Leu Gln Pro Pro Pro Asn Gln Arg Gly Leu Cys Ser Leu 
    450                 455                 460                 


Ala Ala Asp Gly Leu Trp Asn Gln Lys Ile Leu Phe Glu Glu Gln Asp 
465                 470                 475                 480 


Leu Arg Lys His Gly Leu Asp Gly Glu Asp Val Ser Ala Phe Leu Asn 
                485                 490                 495     


Met Asn Ile Phe Gln Lys Asp Ile Asn Cys Glu Arg Tyr Tyr Ser Phe 
            500                 505                 510         


Ile His Leu Ser Phe Gln Glu Phe Phe Ala Ala Met Tyr Tyr Ile Leu 
        515                 520                 525             


Asp Glu Gly Glu Gly Gly Ala Gly Pro Asp Gln Asp Val Thr Arg Leu 
    530                 535                 540                 


Leu Thr Glu Tyr Ala Phe Ser Glu Arg Ser Phe Leu Ala Leu Thr Ser 
545                 550                 555                 560 


Arg Phe Leu Phe Gly Leu Leu Asn Glu Glu Thr Arg Ser His Leu Glu 
                565                 570                 575     


Lys Ser Leu Cys Trp Lys Val Ser Pro His Ile Lys Met Asp Leu Leu 
            580                 585                 590         


Gln Trp Ile Gln Ser Lys Ala Gln Ser Asp Gly Ser Thr Leu Gln Gln 
        595                 600                 605             


Gly Ser Leu Glu Phe Phe Ser Cys Leu Tyr Glu Ile Gln Glu Glu Glu 
    610                 615                 620                 


Phe Ile Gln Gln Ala Leu Ser His Phe Gln Val Ile Val Val Ser Asn 
625                 630                 635                 640 


Ile Ala Ser Lys Met Glu His Met Val Ser Ser Phe Cys Leu Lys Arg 
                645                 650                 655     


Cys Arg Ser Ala Gln Val Leu His Leu Tyr Gly Ala Thr Tyr Ser Ala 
            660                 665                 670         


Asp Gly Glu Asp Arg Ala Arg Cys Ser Ala Gly Ala His Thr Leu Leu 
        675                 680                 685             


Val Gln Leu Pro Glu Arg Thr Val Leu Leu Asp Ala Tyr Ser Glu His 
    690                 695                 700                 


Leu Ala Ala Ala Leu Cys Thr Asn Pro Asn Leu Ile Glu Leu Ser Leu 
705                 710                 715                 720 


Tyr Arg Asn Ala Leu Gly Ser Arg Gly Val Lys Leu Leu Cys Gln Gly 
                725                 730                 735     


Leu Arg His Pro Asn Cys Lys Leu Gln Asn Leu Arg Leu Lys Arg Cys 
            740                 745                 750         


Arg Ile Ser Ser Ser Ala Cys Glu Asp Leu Ser Ala Ala Leu Ile Ala 
        755                 760                 765             


Asn Lys Asn Leu Thr Arg Met Asp Leu Ser Gly Asn Gly Val Gly Phe 
    770                 775                 780                 


Pro Gly Met Met Leu Leu Cys Glu Gly Leu Arg His Pro Gln Cys Arg 
785                 790                 795                 800 


Leu Gln Met Ile Gln Leu Arg Lys Cys Gln Leu Glu Ser Gly Ala Cys 
                805                 810                 815     


Gln Glu Met Ala Ser Val Leu Gly Thr Asn Pro His Leu Val Glu Leu 
            820                 825                 830         


Asp Leu Thr Gly Asn Ala Leu Glu Asp Leu Gly Leu Arg Leu Leu Cys 
        835                 840                 845             


Gln Gly Leu Arg His Pro Val Cys Arg Leu Arg Thr Leu Trp Leu Lys 
    850                 855                 860                 


Ile Cys Arg Leu Thr Ala Ala Ala Cys Asp Glu Leu Ala Ser Thr Leu 
865                 870                 875                 880 


Ser Val Asn Gln Ser Leu Arg Glu Leu Asp Leu Ser Leu Asn Glu Leu 
                885                 890                 895     


Gly Asp Leu Gly Val Leu Leu Leu Cys Glu Gly Leu Arg His Pro Thr 
            900                 905                 910         


Cys Lys Leu Gln Thr Leu Arg Leu Asp Ser Cys Gly Leu Thr Ala Lys 
        915                 920                 925             


Ala Cys Glu Asn Leu Tyr Phe Thr Leu Gly Ile Asn Gln Thr Leu Thr 
    930                 935                 940                 


Asp Leu Tyr Leu Thr Asn Asn Ala Leu Gly Asp Thr Gly Val Arg Leu 
945                 950                 955                 960 


Leu Cys Lys Arg Leu Ser His Pro Gly Cys Lys Leu Arg Val Leu Trp 
                965                 970                 975     


Leu Phe Gly Met Asp Leu Asn Lys Met Thr His Ser Arg Leu Ala Ala 
            980                 985                 990         


Leu Arg Val Thr Lys Pro Tyr Leu  Asp Ile Gly Cys 
        995                 1000                 


<210>  110
<211>  1062
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP12 Isoform 7

<400>  110

Met Leu Arg Thr Ala Gly Arg Asp Gly Leu Cys Arg Leu Ser Thr Tyr 
1               5                   10                  15      


Leu Glu Glu Leu Glu Ala Val Glu Leu Lys Lys Phe Lys Leu Tyr Leu 
            20                  25                  30          


Gly Thr Ala Thr Glu Leu Gly Glu Gly Lys Ile Pro Trp Gly Ser Met 
        35                  40                  45              


Glu Lys Ala Gly Pro Leu Glu Met Ala Gln Leu Leu Ile Thr His Phe 
    50                  55                  60                  


Gly Pro Glu Glu Ala Trp Arg Leu Ala Leu Ser Thr Phe Glu Arg Ile 
65                  70                  75                  80  


Asn Arg Lys Asp Leu Trp Glu Arg Gly Gln Arg Glu Asp Leu Val Arg 
                85                  90                  95      


Asp Thr Pro Pro Gly Gly Pro Ser Ser Leu Gly Asn Gln Ser Thr Cys 
            100                 105                 110         


Leu Leu Glu Val Ser Leu Val Thr Pro Arg Lys Asp Pro Gln Glu Thr 
        115                 120                 125             


Tyr Arg Asp Tyr Val Arg Arg Lys Phe Arg Leu Met Glu Asp Arg Asn 
    130                 135                 140                 


Ala Arg Leu Gly Glu Cys Val Asn Leu Ser His Arg Tyr Thr Arg Leu 
145                 150                 155                 160 


Leu Leu Val Lys Glu His Ser Asn Pro Met Gln Val Gln Gln Gln Leu 
                165                 170                 175     


Leu Asp Thr Gly Arg Gly His Ala Arg Thr Val Gly His Gln Ala Ser 
            180                 185                 190         


Pro Ile Lys Ile Glu Thr Leu Phe Glu Pro Asp Glu Glu Arg Pro Glu 
        195                 200                 205             


Pro Pro Arg Thr Val Val Met Gln Gly Ala Ala Gly Ile Gly Lys Ser 
    210                 215                 220                 


Met Leu Ala His Lys Val Met Leu Asp Trp Ala Asp Gly Lys Leu Phe 
225                 230                 235                 240 


Gln Gly Arg Phe Asp Tyr Leu Phe Tyr Ile Asn Cys Arg Glu Met Asn 
                245                 250                 255     


Gln Ser Ala Thr Glu Cys Ser Met Gln Asp Leu Ile Phe Ser Cys Trp 
            260                 265                 270         


Pro Glu Pro Ser Ala Pro Leu Gln Glu Leu Ile Arg Val Pro Glu Arg 
        275                 280                 285             


Leu Leu Phe Ile Ile Asp Gly Phe Asp Glu Leu Lys Pro Ser Phe His 
    290                 295                 300                 


Asp Pro Gln Gly Pro Trp Cys Leu Cys Trp Glu Glu Lys Arg Pro Thr 
305                 310                 315                 320 


Glu Leu Leu Leu Asn Ser Leu Ile Arg Lys Lys Leu Leu Pro Glu Leu 
                325                 330                 335     


Ser Leu Leu Ile Thr Thr Arg Pro Thr Ala Leu Glu Lys Leu His Arg 
            340                 345                 350         


Leu Leu Glu His Pro Arg His Val Glu Ile Leu Gly Phe Ser Glu Ala 
        355                 360                 365             


Glu Arg Lys Glu Tyr Phe Tyr Lys Tyr Phe His Asn Ala Glu Gln Ala 
    370                 375                 380                 


Gly Gln Val Phe Asn Tyr Val Arg Asp Asn Glu Pro Leu Phe Thr Met 
385                 390                 395                 400 


Cys Phe Val Pro Leu Val Cys Trp Val Val Cys Thr Cys Leu Gln Gln 
                405                 410                 415     


Gln Leu Glu Gly Gly Gly Leu Leu Arg Gln Thr Ser Arg Thr Thr Thr 
            420                 425                 430         


Ala Val Tyr Met Leu Tyr Leu Leu Ser Leu Met Gln Pro Lys Pro Gly 
        435                 440                 445             


Ala Pro Arg Leu Gln Pro Pro Pro Asn Gln Arg Gly Leu Cys Ser Leu 
    450                 455                 460                 


Ala Ala Asp Gly Leu Trp Asn Gln Lys Ile Leu Phe Glu Glu Gln Asp 
465                 470                 475                 480 


Leu Arg Lys His Gly Leu Asp Gly Glu Asp Val Ser Ala Phe Leu Asn 
                485                 490                 495     


Met Asn Ile Phe Gln Lys Asp Ile Asn Cys Glu Arg Tyr Tyr Ser Phe 
            500                 505                 510         


Ile His Leu Ser Phe Gln Glu Phe Phe Ala Ala Met Tyr Tyr Ile Leu 
        515                 520                 525             


Asp Glu Gly Glu Gly Gly Ala Gly Pro Asp Gln Asp Val Thr Arg Leu 
    530                 535                 540                 


Leu Thr Glu Tyr Ala Phe Ser Glu Arg Ser Phe Leu Ala Leu Thr Ser 
545                 550                 555                 560 


Arg Phe Leu Phe Gly Leu Leu Asn Glu Glu Thr Arg Ser His Leu Glu 
                565                 570                 575     


Lys Ser Leu Cys Trp Lys Val Ser Pro His Ile Lys Met Asp Leu Leu 
            580                 585                 590         


Gln Trp Ile Gln Ser Lys Ala Gln Ser Asp Gly Ser Thr Leu Gln Gln 
        595                 600                 605             


Gly Ser Leu Glu Phe Phe Ser Cys Leu Tyr Glu Ile Gln Glu Glu Glu 
    610                 615                 620                 


Phe Ile Gln Gln Ala Leu Ser His Phe Gln Val Ile Val Val Ser Asn 
625                 630                 635                 640 


Ile Ala Ser Lys Met Glu His Met Val Ser Ser Phe Cys Leu Lys Arg 
                645                 650                 655     


Cys Arg Ser Ala Gln Val Leu His Leu Tyr Gly Ala Thr Tyr Ser Ala 
            660                 665                 670         


Asp Gly Glu Asp Arg Ala Arg Cys Ser Ala Gly Ala His Thr Leu Leu 
        675                 680                 685             


Val Gln Leu Arg Pro Glu Arg Thr Val Leu Leu Asp Ala Tyr Ser Glu 
    690                 695                 700                 


His Leu Ala Ala Ala Leu Cys Thr Asn Pro Asn Leu Ile Glu Leu Ser 
705                 710                 715                 720 


Leu Tyr Arg Asn Ala Leu Gly Ser Arg Gly Val Lys Leu Leu Cys Gln 
                725                 730                 735     


Gly Leu Arg His Pro Asn Cys Lys Leu Gln Asn Leu Arg Leu Lys Arg 
            740                 745                 750         


Cys Arg Ile Ser Ser Ser Ala Cys Glu Asp Leu Ser Ala Ala Leu Ile 
        755                 760                 765             


Ala Asn Lys Asn Leu Thr Arg Met Asp Leu Ser Gly Asn Gly Val Gly 
    770                 775                 780                 


Phe Pro Gly Met Met Leu Leu Cys Glu Gly Leu Arg His Pro Gln Cys 
785                 790                 795                 800 


Arg Leu Gln Met Ile Gln Leu Arg Lys Cys Gln Leu Glu Ser Gly Ala 
                805                 810                 815     


Cys Gln Glu Met Ala Ser Val Leu Gly Thr Asn Pro His Leu Val Glu 
            820                 825                 830         


Leu Asp Leu Thr Gly Asn Ala Leu Glu Asp Leu Gly Leu Arg Leu Leu 
        835                 840                 845             


Cys Gln Gly Leu Arg His Pro Val Cys Arg Leu Arg Thr Leu Trp Leu 
    850                 855                 860                 


Lys Ile Cys Arg Leu Thr Ala Ala Ala Cys Asp Glu Leu Ala Ser Thr 
865                 870                 875                 880 


Leu Ser Val Asn Gln Ser Leu Arg Glu Leu Asp Leu Ser Leu Asn Glu 
                885                 890                 895     


Leu Gly Asp Leu Gly Val Leu Leu Leu Cys Glu Gly Leu Arg His Pro 
            900                 905                 910         


Thr Cys Lys Leu Gln Thr Leu Arg Leu Gly Ile Cys Arg Leu Gly Ser 
        915                 920                 925             


Ala Ala Cys Glu Gly Leu Ser Val Val Leu Gln Ala Asn His Asn Leu 
    930                 935                 940                 


Arg Glu Leu Asp Leu Ser Phe Asn Asp Leu Gly Asp Trp Gly Leu Trp 
945                 950                 955                 960 


Leu Leu Ala Glu Gly Leu Gln His Pro Ala Cys Arg Leu Gln Lys Leu 
                965                 970                 975     


Trp Leu Asp Ser Cys Gly Leu Thr Ala Lys Ala Cys Glu Asn Leu Tyr 
            980                 985                 990         


Phe Thr Leu Gly Ile Asn Gln Thr  Leu Thr Asp Leu Tyr  Leu Thr Asn 
        995                 1000                 1005             


Asn Ala  Leu Gly Asp Thr Gly  Val Arg Leu Leu Cys  Lys Arg Leu 
    1010                 1015                 1020             


Ser His  Pro Gly Cys Lys Leu  Arg Val Leu Trp Leu  Phe Gly Met 
    1025                 1030                 1035             


Asp Leu  Asn Lys Met Thr His  Ser Arg Leu Ala Ala  Leu Arg Val 
    1040                 1045                 1050             


Thr Lys  Pro Tyr Leu Asp Ile  Gly Cys 
    1055                 1060         


<210>  111
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIM2 Protein

<400>  111

Met Glu Ser Lys Tyr Lys Glu Ile Leu Leu Leu Thr Gly Leu Asp Asn 
1               5                   10                  15      


Ile Thr Asp Glu Glu Leu Asp Arg Phe Lys Phe Phe Leu Ser Asp Glu 
            20                  25                  30          


Phe Asn Ile Ala Thr Gly Lys Leu His Thr Ala Asn Arg Ile Gln Val 
        35                  40                  45              


Ala Thr Leu Met Ile Gln Asn Ala Gly Ala Val Ser Ala Val Met Lys 
    50                  55                  60                  


Thr Ile Arg Ile Phe Gln Lys Leu Asn Tyr Met Leu Leu Ala Lys Arg 
65                  70                  75                  80  


Leu Gln Glu Glu Lys Glu Lys Val Asp Lys Gln Tyr Lys Ser Val Thr 
                85                  90                  95      


Lys Pro Lys Pro Leu Ser Gln Ala Glu Met Ser Pro Ala Ala Ser Ala 
            100                 105                 110         


Ala Ile Arg Asn Asp Val Ala Lys Gln Arg Ala Ala Pro Lys Val Ser 
        115                 120                 125             


Pro His Val Lys Pro Glu Gln Lys Gln Met Val Ala Gln Gln Glu Ser 
    130                 135                 140                 


Ile Arg Glu Gly Phe Gln Lys Arg Cys Leu Pro Val Met Val Leu Lys 
145                 150                 155                 160 


Ala Lys Lys Pro Phe Thr Phe Glu Thr Gln Glu Gly Lys Gln Glu Met 
                165                 170                 175     


Phe His Ala Thr Val Ala Thr Glu Lys Glu Phe Phe Phe Val Lys Val 
            180                 185                 190         


Phe Asn Thr Leu Leu Lys Asp Lys Phe Ile Pro Lys Arg Ile Ile Ile 
        195                 200                 205             


Ile Ala Arg Tyr Tyr Arg His Ser Gly Phe Leu Glu Val Asn Ser Ala 
    210                 215                 220                 


Ser Arg Val Leu Asp Ala Glu Ser Asp Gln Lys Val Asn Val Pro Leu 
225                 230                 235                 240 


Asn Ile Ile Arg Lys Ala Gly Glu Thr Pro Lys Ile Asn Thr Leu Gln 
                245                 250                 255     


Thr Gln Pro Leu Gly Thr Ile Val Asn Gly Leu Phe Val Val Gln Lys 
            260                 265                 270         


Val Thr Glu Lys Lys Lys Asn Ile Leu Phe Asp Leu Ser Asp Asn Thr 
        275                 280                 285             


Gly Lys Met Glu Val Leu Gly Val Arg Asn Glu Asp Thr Met Lys Cys 
    290                 295                 300                 


Lys Glu Gly Asp Lys Val Arg Leu Thr Phe Phe Thr Leu Ser Lys Asn 
305                 310                 315                 320 


Gly Glu Lys Leu Gln Leu Thr Ser Gly Val His Ser Thr Ile Lys Val 
                325                 330                 335     


Ile Lys Ala Lys Lys Lys Thr 
            340             


<210>  112
<211>  785
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFI-16 Isoform 1

<400>  112

Met Gly Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val 
1               5                   10                  15      


Ile Asn Asp Tyr His Phe Arg Met Val Lys Ser Leu Leu Ser Asn Asp 
            20                  25                  30          


Leu Lys Leu Asn Leu Lys Met Arg Glu Glu Tyr Asp Lys Ile Gln Ile 
        35                  40                  45              


Ala Asp Leu Met Glu Glu Lys Phe Arg Gly Asp Ala Gly Leu Gly Lys 
    50                  55                  60                  


Leu Ile Lys Ile Phe Glu Asp Ile Pro Thr Leu Glu Asp Leu Ala Glu 
65                  70                  75                  80  


Thr Leu Lys Lys Glu Lys Leu Lys Val Lys Gly Pro Ala Leu Ser Arg 
                85                  90                  95      


Lys Arg Lys Lys Glu Val Asp Ala Thr Ser Pro Ala Pro Ser Thr Ser 
            100                 105                 110         


Ser Thr Val Lys Thr Glu Gly Ala Glu Ala Thr Pro Gly Ala Gln Lys 
        115                 120                 125             


Arg Lys Lys Ser Thr Lys Glu Lys Ala Gly Pro Lys Gly Ser Lys Val 
    130                 135                 140                 


Ser Glu Glu Gln Thr Gln Pro Pro Ser Pro Ala Gly Ala Gly Met Ser 
145                 150                 155                 160 


Thr Ala Met Gly Arg Ser Pro Ser Pro Lys Thr Ser Leu Ser Ala Pro 
                165                 170                 175     


Pro Asn Ser Ser Ser Thr Glu Asn Pro Lys Thr Val Ala Lys Cys Gln 
            180                 185                 190         


Val Thr Pro Arg Arg Asn Val Leu Gln Lys Arg Pro Val Ile Val Lys 
        195                 200                 205             


Val Leu Ser Thr Thr Lys Pro Phe Glu Tyr Glu Thr Pro Glu Met Glu 
    210                 215                 220                 


Lys Lys Ile Met Phe His Ala Thr Val Ala Thr Gln Thr Gln Phe Phe 
225                 230                 235                 240 


His Val Lys Val Leu Asn Thr Ser Leu Lys Glu Lys Phe Asn Gly Lys 
                245                 250                 255     


Lys Ile Ile Ile Ile Ser Asp Tyr Leu Glu Tyr Asp Ser Leu Leu Glu 
            260                 265                 270         


Val Asn Glu Glu Ser Thr Val Ser Glu Ala Gly Pro Asn Gln Thr Phe 
        275                 280                 285             


Glu Val Pro Asn Lys Ile Ile Asn Arg Ala Lys Glu Thr Leu Lys Ile 
    290                 295                 300                 


Asp Ile Leu His Lys Gln Ala Ser Gly Asn Ile Val Tyr Gly Val Phe 
305                 310                 315                 320 


Met Leu His Lys Lys Thr Val Asn Gln Lys Thr Thr Ile Tyr Glu Ile 
                325                 330                 335     


Gln Asp Asp Arg Gly Lys Met Asp Val Val Gly Thr Gly Gln Cys His 
            340                 345                 350         


Asn Ile Pro Cys Glu Glu Gly Asp Lys Leu Gln Leu Phe Cys Phe Arg 
        355                 360                 365             


Leu Arg Lys Lys Asn Gln Met Ser Lys Leu Ile Ser Glu Met His Ser 
    370                 375                 380                 


Phe Ile Gln Ile Lys Lys Lys Thr Asn Pro Arg Asn Asn Asp Pro Lys 
385                 390                 395                 400 


Ser Met Lys Leu Pro Gln Glu Gln Arg Gln Leu Pro Tyr Pro Ser Glu 
                405                 410                 415     


Ala Ser Thr Thr Phe Pro Glu Ser His Leu Arg Thr Pro Gln Met Pro 
            420                 425                 430         


Pro Thr Thr Pro Ser Ser Ser Phe Phe Thr Lys Lys Ser Glu Asp Thr 
        435                 440                 445             


Ile Ser Lys Met Asn Asp Phe Met Arg Met Gln Ile Leu Lys Glu Gly 
    450                 455                 460                 


Ser His Phe Pro Gly Pro Phe Met Thr Ser Ile Gly Pro Ala Glu Ser 
465                 470                 475                 480 


His Pro His Thr Pro Gln Met Pro Pro Ser Thr Pro Ser Ser Ser Phe 
                485                 490                 495     


Leu Thr Thr Lys Ser Glu Asp Thr Ile Ser Lys Met Asn Asp Phe Met 
            500                 505                 510         


Arg Met Gln Ile Leu Lys Glu Gly Ser His Phe Pro Gly Pro Phe Met 
        515                 520                 525             


Thr Ser Ile Gly Pro Ala Glu Ser His Pro His Thr Pro Gln Met Pro 
    530                 535                 540                 


Pro Ser Thr Pro Ser Ser Ser Phe Leu Thr Thr Leu Lys Pro Arg Leu 
545                 550                 555                 560 


Lys Thr Glu Pro Glu Glu Val Ser Ile Glu Asp Ser Ala Gln Ser Asp 
                565                 570                 575     


Leu Lys Glu Val Met Val Leu Asn Ala Thr Glu Ser Phe Val Tyr Glu 
            580                 585                 590         


Pro Lys Glu Gln Lys Lys Met Phe His Ala Thr Val Ala Thr Glu Asn 
        595                 600                 605             


Glu Val Phe Arg Val Lys Val Phe Asn Ile Asp Leu Lys Glu Lys Phe 
    610                 615                 620                 


Thr Pro Lys Lys Ile Ile Ala Ile Ala Asn Tyr Val Cys Arg Asn Gly 
625                 630                 635                 640 


Phe Leu Glu Val Tyr Pro Phe Thr Leu Val Ala Asp Val Asn Ala Asp 
                645                 650                 655     


Arg Asn Met Glu Ile Pro Lys Gly Leu Ile Arg Ser Ala Ser Val Thr 
            660                 665                 670         


Pro Lys Ile Asn Gln Leu Cys Ser Gln Thr Lys Gly Ser Phe Val Asn 
        675                 680                 685             


Gly Val Phe Glu Val His Lys Lys Asn Val Arg Gly Glu Phe Thr Tyr 
    690                 695                 700                 


Tyr Glu Ile Gln Asp Asn Thr Gly Lys Met Glu Val Val Val His Gly 
705                 710                 715                 720 


Arg Leu Thr Thr Ile Asn Cys Glu Glu Gly Asp Lys Leu Lys Leu Thr 
                725                 730                 735     


Cys Phe Glu Leu Ala Pro Lys Ser Gly Asn Thr Gly Glu Leu Arg Ser 
            740                 745                 750         


Val Ile His Ser His Ile Lys Val Ile Lys Thr Arg Lys Asn Lys Lys 
        755                 760                 765             


Asp Ile Leu Asn Pro Asp Ser Ser Met Glu Thr Ser Pro Asp Phe Phe 
    770                 775                 780                 


Phe 
785 


<210>  113
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFI-16 Isoform 2

<400>  113

Met Gly Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val 
1               5                   10                  15      


Ile Asn Asp Tyr His Phe Arg Met Val Lys Ser Leu Leu Ser Asn Asp 
            20                  25                  30          


Leu Lys Leu Asn Leu Lys Met Arg Glu Glu Tyr Asp Lys Ile Gln Ile 
        35                  40                  45              


Ala Asp Leu Met Glu Glu Lys Phe Arg Gly Asp Ala Gly Leu Gly Lys 
    50                  55                  60                  


Leu Ile Lys Ile Phe Glu Asp Ile Pro Thr Leu Glu Asp Leu Ala Glu 
65                  70                  75                  80  


Thr Leu Lys Lys Glu Lys Leu Lys Val Lys Gly Pro Ala Leu Ser Arg 
                85                  90                  95      


Lys Arg Lys Lys Glu Val Asp Ala Thr Ser Pro Ala Pro Ser Thr Ser 
            100                 105                 110         


Ser Thr Val Lys Thr Glu Gly Ala Glu Ala Thr Pro Gly Ala Gln Lys 
        115                 120                 125             


Arg Lys Lys Ser Thr Lys Glu Lys Ala Gly Pro Lys Gly Ser Lys Val 
    130                 135                 140                 


Ser Glu Glu Gln Thr Gln Pro Pro Ser Pro Ala Gly Ala Gly Met Ser 
145                 150                 155                 160 


Thr Ala Met Gly Arg Ser Pro Ser Pro Lys Thr Ser Leu Ser Ala Pro 
                165                 170                 175     


Pro Asn Ser Ser Ser Thr Glu Asn Pro Lys Thr Val Ala Lys Cys Gln 
            180                 185                 190         


Val Thr Pro Arg Arg Asn Val Leu Gln Lys Arg Pro Val Ile Val Lys 
        195                 200                 205             


Val Leu Ser Thr Thr Lys Pro Phe Glu Tyr Glu Thr Pro Glu Met Glu 
    210                 215                 220                 


Lys Lys Ile Met Phe His Ala Thr Val Ala Thr Gln Thr Gln Phe Phe 
225                 230                 235                 240 


His Val Lys Val Leu Asn Thr Ser Leu Lys Glu Lys Phe Asn Gly Lys 
                245                 250                 255     


Lys Ile Ile Ile Ile Ser Asp Tyr Leu Glu Tyr Asp Ser Leu Leu Glu 
            260                 265                 270         


Val Asn Glu Glu Ser Thr Val Ser Glu Ala Gly Pro Asn Gln Thr Phe 
        275                 280                 285             


Glu Val Pro Asn Lys Ile Ile Asn Arg Ala Lys Glu Thr Leu Lys Ile 
    290                 295                 300                 


Asp Ile Leu His Lys Gln Ala Ser Gly Asn Ile Val Tyr Gly Val Phe 
305                 310                 315                 320 


Met Leu His Lys Lys Thr Val Asn Gln Lys Thr Thr Ile Tyr Glu Ile 
                325                 330                 335     


Gln Asp Asp Arg Gly Lys Met Asp Val Val Gly Thr Gly Gln Cys His 
            340                 345                 350         


Asn Ile Pro Cys Glu Glu Gly Asp Lys Leu Gln Leu Phe Cys Phe Arg 
        355                 360                 365             


Leu Arg Lys Lys Asn Gln Met Ser Lys Leu Ile Ser Glu Met His Ser 
    370                 375                 380                 


Phe Ile Gln Ile Lys Lys Lys Thr Asn Pro Arg Asn Asn Asp Pro Lys 
385                 390                 395                 400 


Ser Met Lys Leu Pro Gln Glu Gln Arg Gln Leu Pro Tyr Pro Ser Glu 
                405                 410                 415     


Ala Ser Thr Thr Phe Pro Glu Ser His Leu Arg Thr Pro Gln Met Pro 
            420                 425                 430         


Pro Thr Thr Pro Ser Ser Ser Phe Phe Thr Lys Lys Ser Glu Asp Thr 
        435                 440                 445             


Ile Ser Lys Met Asn Asp Phe Met Arg Met Gln Ile Leu Lys Glu Gly 
    450                 455                 460                 


Ser His Phe Pro Gly Pro Phe Met Thr Ser Ile Gly Pro Ala Glu Ser 
465                 470                 475                 480 


His Pro His Thr Pro Gln Met Pro Pro Ser Thr Pro Ser Ser Ser Phe 
                485                 490                 495     


Leu Thr Thr Leu Lys Pro Arg Leu Lys Thr Glu Pro Glu Glu Val Ser 
            500                 505                 510         


Ile Glu Asp Ser Ala Gln Ser Asp Leu Lys Glu Val Met Val Leu Asn 
        515                 520                 525             


Ala Thr Glu Ser Phe Val Tyr Glu Pro Lys Glu Gln Lys Lys Met Phe 
    530                 535                 540                 


His Ala Thr Val Ala Thr Glu Asn Glu Val Phe Arg Val Lys Val Phe 
545                 550                 555                 560 


Asn Ile Asp Leu Lys Glu Lys Phe Thr Pro Lys Lys Ile Ile Ala Ile 
                565                 570                 575     


Ala Asn Tyr Val Cys Arg Asn Gly Phe Leu Glu Val Tyr Pro Phe Thr 
            580                 585                 590         


Leu Val Ala Asp Val Asn Ala Asp Arg Asn Met Glu Ile Pro Lys Gly 
        595                 600                 605             


Leu Ile Arg Ser Ala Ser Val Thr Pro Lys Ile Asn Gln Leu Cys Ser 
    610                 615                 620                 


Gln Thr Lys Gly Ser Phe Val Asn Gly Val Phe Glu Val His Lys Lys 
625                 630                 635                 640 


Asn Val Arg Gly Glu Phe Thr Tyr Tyr Glu Ile Gln Asp Asn Thr Gly 
                645                 650                 655     


Lys Met Glu Val Val Val His Gly Arg Leu Thr Thr Ile Asn Cys Glu 
            660                 665                 670         


Glu Gly Asp Lys Leu Lys Leu Thr Cys Phe Glu Leu Ala Pro Lys Ser 
        675                 680                 685             


Gly Asn Thr Gly Glu Leu Arg Ser Val Ile His Ser His Ile Lys Val 
    690                 695                 700                 


Ile Lys Thr Arg Lys Asn Lys Lys Asp Ile Leu Asn Pro Asp Ser Ser 
705                 710                 715                 720 


Met Glu Thr Ser Pro Asp Phe Phe Phe 
                725                 


<210>  114
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFI-16 Isoform 3

<400>  114

Met Gly Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val 
1               5                   10                  15      


Ile Asn Asp Tyr His Phe Arg Met Val Lys Ser Leu Leu Ser Asn Asp 
            20                  25                  30          


Leu Lys Leu Asn Leu Lys Met Arg Glu Glu Tyr Asp Lys Ile Gln Ile 
        35                  40                  45              


Ala Asp Leu Met Glu Glu Lys Phe Arg Gly Asp Ala Gly Leu Gly Lys 
    50                  55                  60                  


Leu Ile Lys Ile Phe Glu Asp Ile Pro Thr Leu Glu Asp Leu Ala Glu 
65                  70                  75                  80  


Thr Leu Lys Lys Glu Lys Leu Lys Val Lys Gly Pro Ala Leu Ser Arg 
                85                  90                  95      


Lys Arg Lys Lys Glu Val Asp Ala Thr Ser Pro Ala Pro Ser Thr Ser 
            100                 105                 110         


Ser Thr Val Lys Thr Glu Gly Ala Glu Ala Thr Pro Gly Ala Gln Lys 
        115                 120                 125             


Arg Lys Lys Ser Thr Lys Glu Lys Ala Gly Pro Lys Gly Ser Lys Val 
    130                 135                 140                 


Ser Glu Glu Gln Thr Gln Pro Pro Ser Pro Ala Gly Ala Gly Met Ser 
145                 150                 155                 160 


Thr Ala Met Gly Arg Ser Pro Ser Pro Lys Thr Ser Leu Ser Ala Pro 
                165                 170                 175     


Pro Asn Ser Ser Ser Thr Glu Asn Pro Lys Thr Val Ala Lys Cys Gln 
            180                 185                 190         


Val Thr Pro Arg Arg Asn Val Leu Gln Lys Arg Pro Val Ile Val Lys 
        195                 200                 205             


Val Leu Ser Thr Thr Lys Pro Phe Glu Tyr Glu Thr Pro Glu Met Glu 
    210                 215                 220                 


Lys Lys Ile Met Phe His Ala Thr Val Ala Thr Gln Thr Gln Phe Phe 
225                 230                 235                 240 


His Val Lys Val Leu Asn Thr Ser Leu Lys Glu Lys Phe Asn Gly Lys 
                245                 250                 255     


Lys Ile Ile Ile Ile Ser Asp Tyr Leu Glu Tyr Asp Ser Leu Leu Glu 
            260                 265                 270         


Val Asn Glu Glu Ser Thr Val Ser Glu Ala Gly Pro Asn Gln Thr Phe 
        275                 280                 285             


Glu Val Pro Asn Lys Ile Ile Asn Arg Ala Lys Glu Thr Leu Lys Ile 
    290                 295                 300                 


Asp Ile Leu His Lys Gln Ala Ser Gly Asn Ile Val Tyr Gly Val Phe 
305                 310                 315                 320 


Met Leu His Lys Lys Thr Val Asn Gln Lys Thr Thr Ile Tyr Glu Ile 
                325                 330                 335     


Gln Asp Asp Arg Gly Lys Met Asp Val Val Gly Thr Gly Gln Cys His 
            340                 345                 350         


Asn Ile Pro Cys Glu Glu Gly Asp Lys Leu Gln Leu Phe Cys Phe Arg 
        355                 360                 365             


Leu Arg Lys Lys Asn Gln Met Ser Lys Leu Ile Ser Glu Met His Ser 
    370                 375                 380                 


Phe Ile Gln Ile Lys Lys Lys Thr Asn Pro Arg Asn Asn Asp Pro Lys 
385                 390                 395                 400 


Ser Met Lys Leu Pro Gln Glu Gln Arg Gln Leu Pro Tyr Pro Ser Glu 
                405                 410                 415     


Ala Ser Thr Thr Phe Pro Glu Ser His Leu Arg Thr Pro Gln Met Pro 
            420                 425                 430         


Pro Thr Thr Pro Ser Ser Ser Phe Phe Thr Lys Leu Lys Pro Arg Leu 
        435                 440                 445             


Lys Thr Glu Pro Glu Glu Val Ser Ile Glu Asp Ser Ala Gln Ser Asp 
    450                 455                 460                 


Leu Lys Glu Val Met Val Leu Asn Ala Thr Glu Ser Phe Val Tyr Glu 
465                 470                 475                 480 


Pro Lys Glu Gln Lys Lys Met Phe His Ala Thr Val Ala Thr Glu Asn 
                485                 490                 495     


Glu Val Phe Arg Val Lys Val Phe Asn Ile Asp Leu Lys Glu Lys Phe 
            500                 505                 510         


Thr Pro Lys Lys Ile Ile Ala Ile Ala Asn Tyr Val Cys Arg Asn Gly 
        515                 520                 525             


Phe Leu Glu Val Tyr Pro Phe Thr Leu Val Ala Asp Val Asn Ala Asp 
    530                 535                 540                 


Arg Asn Met Glu Ile Pro Lys Gly Leu Ile Arg Ser Ala Ser Val Thr 
545                 550                 555                 560 


Pro Lys Ile Asn Gln Leu Cys Ser Gln Thr Lys Gly Ser Phe Val Asn 
                565                 570                 575     


Gly Val Phe Glu Val His Lys Lys Asn Val Arg Gly Glu Phe Thr Tyr 
            580                 585                 590         


Tyr Glu Ile Gln Asp Asn Thr Gly Lys Met Glu Val Val Val His Gly 
        595                 600                 605             


Arg Leu Thr Thr Ile Asn Cys Glu Glu Gly Asp Lys Leu Lys Leu Thr 
    610                 615                 620                 


Cys Phe Glu Leu Ala Pro Lys Ser Gly Asn Thr Gly Glu Leu Arg Ser 
625                 630                 635                 640 


Val Ile His Ser His Ile Lys Val Ile Lys Thr Arg Lys Asn Lys Lys 
                645                 650                 655     


Asp Ile Leu Asn Pro Asp Ser Ser Met Glu Thr Ser Pro Asp Phe Phe 
            660                 665                 670         


Phe 
    


<210>  115
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFI-16 Isoform 4

<400>  115

Met Gly Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val 
1               5                   10                  15      


Ile Asn Asp Tyr His Phe Arg Met Val Lys Ser Leu Leu Ser Asn Asp 
            20                  25                  30          


Leu Lys Leu Asn Leu Lys Met Arg Glu Glu Tyr Asp Lys Ile Gln Ile 
        35                  40                  45              


Ala Asp Leu Met Glu Glu Lys Phe Arg Gly Asp Ala Gly Leu Gly Lys 
    50                  55                  60                  


Leu Ile Lys Ile Phe Glu Asp Ile Pro Thr Leu Glu Asp Leu Ala Glu 
65                  70                  75                  80  


Thr Leu Lys Lys Glu Lys Leu Lys Val Lys Gly Pro Ala Leu Ser Arg 
                85                  90                  95      


Lys Arg Lys Lys Glu Val Asp Ala Thr Ser Pro Ala Pro Ser Thr Ser 
            100                 105                 110         


Ser Thr Val Lys Thr Glu Gly Ala Glu Ala Thr Pro Gly Ala Gln Asn 
        115                 120                 125             


Pro Lys Thr Val Ala Lys Cys Gln Val Thr Pro Arg Arg Asn Val Leu 
    130                 135                 140                 


Gln Lys Arg Pro Val Ile Val Lys Val Leu Ser Thr Thr Lys Pro Phe 
145                 150                 155                 160 


Glu Tyr Glu Thr Pro Glu Met Glu Lys Lys Ile Met Phe His Ala Thr 
                165                 170                 175     


Val Ala Thr Gln Thr Gln Phe Phe His Val Lys Val Leu Asn Thr Ser 
            180                 185                 190         


Leu Lys Glu Lys Phe Asn Gly Lys Lys Ile Ile Ile Ile Ser Asp Tyr 
        195                 200                 205             


Leu Glu Tyr Asp Ser Leu Leu Glu Val Asn Glu Glu Ser Thr Val Ser 
    210                 215                 220                 


Glu Ala Gly Pro Asn Gln Thr Phe Glu Val Pro Asn Lys Ile Ile Asn 
225                 230                 235                 240 


Arg Ala Lys Glu Thr Leu Lys Ile Asp Ile Leu His Lys Gln Ala Ser 
                245                 250                 255     


Gly Asn Ile Val Tyr Gly Val Phe Met Leu His Lys Lys Thr Val Asn 
            260                 265                 270         


Gln Lys Thr Thr Ile Tyr Glu Ile Gln Asp Asp Arg Gly Lys Met Asp 
        275                 280                 285             


Val Val Gly Thr Gly Gln Cys His Asn Ile Pro Cys Glu Glu Gly Asp 
    290                 295                 300                 


Lys Leu Gln Leu Phe Cys Phe Arg Leu Arg Lys Lys Asn Gln Met Ser 
305                 310                 315                 320 


Lys Leu Ile Ser Glu Met His Ser Phe Ile Gln Ile Lys Lys Lys Thr 
                325                 330                 335     


Asn Pro Arg Asn Asn Asp Pro Lys Ser Met Lys Leu Pro Gln Glu Gln 
            340                 345                 350         


Arg Gln Leu Pro Tyr Pro Ser Glu Ala Ser Thr Thr Phe Pro Glu Ser 
        355                 360                 365             


His Leu Arg Thr Pro Gln Met Pro Pro Thr Thr Pro Ser Ser Ser Phe 
    370                 375                 380                 


Phe Thr Lys Lys Ser Glu Asp Thr Ile Ser Lys Met Asn Asp Phe Met 
385                 390                 395                 400 


Arg Met Gln Ile Leu Lys Glu Gly Ser His Phe Pro Gly Pro Phe Met 
                405                 410                 415     


Thr Ser Ile Gly Pro Ala Glu Ser His Pro His Thr Pro Gln Met Pro 
            420                 425                 430         


Pro Ser Thr Pro Ser Ser Ser Phe Leu Thr Thr Lys Ser Glu Asp Thr 
        435                 440                 445             


Ile Ser Lys Met Asn Asp Phe Met Arg Met Gln Ile Leu Lys Glu Gly 
    450                 455                 460                 


Ser His Phe Pro Gly Pro Phe Met Thr Ser Ile Gly Pro Ala Glu Ser 
465                 470                 475                 480 


His Pro His Thr Pro Gln Met Pro Pro Ser Thr Pro Ser Ser Ser Phe 
                485                 490                 495     


Leu Thr Thr Leu Lys Pro Arg Leu Lys Thr Glu Pro Glu Glu Val Ser 
            500                 505                 510         


Ile Glu Asp Ser Ala Gln Ser Asp Leu Lys Glu Val Met Val Leu Asn 
        515                 520                 525             


Ala Thr Glu Ser Phe Val Tyr Glu Pro Lys Glu Gln Lys Lys Met Phe 
    530                 535                 540                 


His Ala Thr Val Ala Thr Glu Asn Glu Val Phe Arg Val Lys Val Phe 
545                 550                 555                 560 


Asn Ile Asp Leu Lys Glu Lys Phe Thr Pro Lys Lys Ile Ile Ala Ile 
                565                 570                 575     


Ala Asn Tyr Val Cys Arg Asn Gly Phe Leu Glu Val Tyr Pro Phe Thr 
            580                 585                 590         


Leu Val Ala Asp Val Asn Ala Asp Arg Asn Met Glu Ile Pro Lys Gly 
        595                 600                 605             


Leu Ile Arg Ser Ala Ser Val Thr Pro Lys Ile Asn Gln Leu Cys Ser 
    610                 615                 620                 


Gln Thr Lys Gly Ser Phe Val Asn Gly Val Phe Glu Val His Lys Lys 
625                 630                 635                 640 


Asn Val Arg Gly Glu Phe Thr Tyr Tyr Glu Ile Gln Asp Asn Thr Gly 
                645                 650                 655     


Lys Met Glu Val Val Val His Gly Arg Leu Thr Thr Ile Asn Cys Glu 
            660                 665                 670         


Glu Gly Asp Lys Leu Lys Leu Thr Cys Phe Glu Leu Ala Pro Lys Ser 
        675                 680                 685             


Gly Asn Thr Gly Glu Leu Arg Ser Val Ile His Ser His Ile Lys Val 
    690                 695                 700                 


Ile Lys Thr Arg Lys Asn Lys Lys Asp Ile Leu Asn Pro Asp Ser Ser 
705                 710                 715                 720 


Met Glu Thr Ser Pro Asp Phe Phe Phe 
                725                 


<210>  116
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pyrin Isoform 1

<400>  116

Met Ala Lys Thr Pro Ser Asp His Leu Leu Ser Thr Leu Glu Glu Leu 
1               5                   10                  15      


Val Pro Tyr Asp Phe Glu Lys Phe Lys Phe Lys Leu Gln Asn Thr Ser 
            20                  25                  30          


Val Gln Lys Glu His Ser Arg Ile Pro Arg Ser Gln Ile Gln Arg Ala 
        35                  40                  45              


Arg Pro Val Lys Met Ala Thr Leu Leu Val Thr Tyr Tyr Gly Glu Glu 
    50                  55                  60                  


Tyr Ala Val Gln Leu Thr Leu Gln Val Leu Arg Ala Ile Asn Gln Arg 
65                  70                  75                  80  


Leu Leu Ala Glu Glu Leu His Arg Ala Ala Ile Gln Glu Tyr Ser Thr 
                85                  90                  95      


Gln Glu Asn Gly Thr Asp Asp Ser Ala Ala Ser Ser Ser Leu Gly Glu 
            100                 105                 110         


Asn Lys Pro Arg Ser Leu Lys Thr Pro Asp His Pro Glu Gly Asn Glu 
        115                 120                 125             


Gly Asn Gly Pro Arg Pro Tyr Gly Gly Gly Ala Ala Ser Leu Arg Cys 
    130                 135                 140                 


Ser Gln Pro Glu Ala Gly Arg Gly Leu Ser Arg Lys Pro Leu Ser Lys 
145                 150                 155                 160 


Arg Arg Glu Lys Ala Ser Glu Gly Leu Asp Ala Gln Gly Lys Pro Arg 
                165                 170                 175     


Thr Arg Ser Pro Ala Leu Pro Gly Gly Arg Ser Pro Gly Pro Cys Arg 
            180                 185                 190         


Ala Leu Glu Gly Gly Gln Ala Glu Val Arg Leu Arg Arg Asn Ala Ser 
        195                 200                 205             


Ser Ala Gly Arg Leu Gln Gly Leu Ala Gly Gly Ala Pro Gly Gln Lys 
    210                 215                 220                 


Glu Cys Arg Pro Phe Glu Val Tyr Leu Pro Ser Gly Lys Met Arg Pro 
225                 230                 235                 240 


Arg Ser Leu Glu Val Thr Ile Ser Thr Gly Glu Lys Ala Pro Ala Asn 
                245                 250                 255     


Pro Glu Ile Leu Leu Thr Leu Glu Glu Lys Thr Ala Ala Asn Leu Asp 
            260                 265                 270         


Ser Ala Thr Glu Pro Arg Ala Arg Pro Thr Pro Asp Gly Gly Ala Ser 
        275                 280                 285             


Ala Asp Leu Lys Glu Gly Pro Gly Asn Pro Glu His Ser Val Thr Gly 
    290                 295                 300                 


Arg Pro Pro Asp Thr Ala Ala Ser Pro Arg Cys His Ala Gln Glu Gly 
305                 310                 315                 320 


Asp Pro Val Asp Gly Thr Cys Val Arg Asp Ser Cys Ser Phe Pro Glu 
                325                 330                 335     


Ala Val Ser Gly His Pro Gln Ala Ser Gly Ser Arg Ser Pro Gly Cys 
            340                 345                 350         


Pro Arg Cys Gln Asp Ser His Glu Arg Lys Ser Pro Gly Ser Leu Ser 
        355                 360                 365             


Pro Gln Pro Leu Pro Gln Cys Lys Arg His Leu Lys Gln Val Gln Leu 
    370                 375                 380                 


Leu Phe Cys Glu Asp His Asp Glu Pro Ile Cys Leu Ile Cys Ser Leu 
385                 390                 395                 400 


Ser Gln Glu His Gln Gly His Arg Val Arg Pro Ile Glu Glu Val Ala 
                405                 410                 415     


Leu Glu His Lys Lys Lys Ile Gln Lys Gln Leu Glu His Leu Lys Lys 
            420                 425                 430         


Leu Arg Lys Ser Gly Glu Glu Gln Arg Ser Tyr Gly Glu Glu Lys Ala 
        435                 440                 445             


Val Ser Phe Leu Lys Gln Thr Glu Ala Leu Lys Gln Arg Val Gln Arg 
    450                 455                 460                 


Lys Leu Glu Gln Val Tyr Tyr Phe Leu Glu Gln Gln Glu His Phe Phe 
465                 470                 475                 480 


Val Ala Ser Leu Glu Asp Val Gly Gln Met Val Gly Gln Ile Arg Lys 
                485                 490                 495     


Ala Tyr Asp Thr Arg Val Ser Gln Asp Ile Ala Leu Leu Asp Ala Leu 
            500                 505                 510         


Ile Gly Glu Leu Glu Ala Lys Glu Cys Gln Ser Glu Trp Glu Leu Leu 
        515                 520                 525             


Gln Asp Ile Gly Asp Ile Leu His Arg Ala Lys Thr Val Pro Val Pro 
    530                 535                 540                 


Glu Lys Trp Thr Thr Pro Gln Glu Ile Lys Gln Lys Ile Gln Leu Leu 
545                 550                 555                 560 


His Gln Lys Ser Glu Phe Val Glu Lys Ser Thr Lys Tyr Phe Ser Glu 
                565                 570                 575     


Thr Leu Arg Ser Glu Met Glu Met Phe Asn Val Pro Glu Leu Ile Gly 
            580                 585                 590         


Ala Gln Ala His Ala Val Asn Val Ile Leu Asp Ala Glu Thr Ala Tyr 
        595                 600                 605             


Pro Asn Leu Ile Phe Ser Asp Asp Leu Lys Ser Val Arg Leu Gly Asn 
    610                 615                 620                 


Lys Trp Glu Arg Leu Pro Asp Gly Pro Gln Arg Phe Asp Ser Cys Ile 
625                 630                 635                 640 


Ile Val Leu Gly Ser Pro Ser Phe Leu Ser Gly Arg Arg Tyr Trp Glu 
                645                 650                 655     


Val Glu Val Gly Asp Lys Thr Ala Trp Ile Leu Gly Ala Cys Lys Thr 
            660                 665                 670         


Ser Ile Ser Arg Lys Gly Asn Met Thr Leu Ser Pro Glu Asn Gly Tyr 
        675                 680                 685             


Trp Val Val Ile Met Met Lys Glu Asn Glu Tyr Gln Ala Ser Ser Val 
    690                 695                 700                 


Pro Pro Thr Arg Leu Leu Ile Lys Glu Pro Pro Lys Arg Val Gly Ile 
705                 710                 715                 720 


Phe Val Asp Tyr Arg Val Gly Ser Ile Ser Phe Tyr Asn Val Thr Ala 
                725                 730                 735     


Arg Ser His Ile Tyr Thr Phe Ala Ser Cys Ser Phe Ser Gly Pro Leu 
            740                 745                 750         


Gln Pro Ile Phe Ser Pro Gly Thr Arg Asp Gly Gly Lys Asn Thr Ala 
        755                 760                 765             


Pro Leu Thr Ile Cys Pro Val Gly Gly Gln Gly Pro Asp 
    770                 775                 780     


<210>  117
<211>  570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pyrin Isoform 2

<400>  117

Met Ala Lys Thr Pro Ser Asp His Leu Leu Ser Thr Leu Glu Glu Leu 
1               5                   10                  15      


Val Pro Tyr Asp Phe Glu Lys Phe Lys Phe Lys Leu Gln Asn Thr Ser 
            20                  25                  30          


Val Gln Lys Glu His Ser Arg Ile Pro Arg Ser Gln Ile Gln Arg Ala 
        35                  40                  45              


Arg Pro Val Lys Met Ala Thr Leu Leu Val Thr Tyr Tyr Gly Glu Glu 
    50                  55                  60                  


Tyr Ala Val Gln Leu Thr Leu Gln Val Leu Arg Ala Ile Asn Gln Arg 
65                  70                  75                  80  


Leu Leu Ala Glu Glu Leu His Arg Ala Ala Ile Gln Gly Arg Pro Pro 
                85                  90                  95      


Asp Thr Ala Ala Ser Pro Arg Cys His Ala Gln Glu Gly Asp Pro Val 
            100                 105                 110         


Asp Gly Thr Cys Val Arg Asp Ser Cys Ser Phe Pro Glu Ala Val Ser 
        115                 120                 125             


Gly His Pro Gln Ala Ser Gly Ser Arg Ser Pro Gly Cys Pro Arg Cys 
    130                 135                 140                 


Gln Asp Ser His Glu Arg Lys Ser Pro Gly Ser Leu Ser Pro Gln Pro 
145                 150                 155                 160 


Leu Pro Gln Cys Lys Arg His Leu Lys Gln Val Gln Leu Leu Phe Cys 
                165                 170                 175     


Glu Asp His Asp Glu Pro Ile Cys Leu Ile Cys Ser Leu Ser Gln Glu 
            180                 185                 190         


His Gln Gly His Arg Val Arg Pro Ile Glu Glu Val Ala Leu Glu His 
        195                 200                 205             


Lys Lys Lys Ile Gln Lys Gln Leu Glu His Leu Lys Lys Leu Arg Lys 
    210                 215                 220                 


Ser Gly Glu Glu Gln Arg Ser Tyr Gly Glu Glu Lys Ala Val Ser Phe 
225                 230                 235                 240 


Leu Lys Gln Thr Glu Ala Leu Lys Gln Arg Val Gln Arg Lys Leu Glu 
                245                 250                 255     


Gln Val Tyr Tyr Phe Leu Glu Gln Gln Glu His Phe Phe Val Ala Ser 
            260                 265                 270         


Leu Glu Asp Val Gly Gln Met Val Gly Gln Ile Arg Lys Ala Tyr Asp 
        275                 280                 285             


Thr Arg Val Ser Gln Asp Ile Ala Leu Leu Asp Ala Leu Ile Gly Glu 
    290                 295                 300                 


Leu Glu Ala Lys Glu Cys Gln Ser Glu Trp Glu Leu Leu Gln Asp Ile 
305                 310                 315                 320 


Gly Asp Ile Leu His Arg Ala Lys Thr Val Pro Val Pro Glu Lys Trp 
                325                 330                 335     


Thr Thr Pro Gln Glu Ile Lys Gln Lys Ile Gln Leu Leu His Gln Lys 
            340                 345                 350         


Ser Glu Phe Val Glu Lys Ser Thr Lys Tyr Phe Ser Glu Thr Leu Arg 
        355                 360                 365             


Ser Glu Met Glu Met Phe Asn Val Pro Glu Leu Ile Gly Ala Gln Ala 
    370                 375                 380                 


His Ala Val Asn Val Ile Leu Asp Ala Glu Thr Ala Tyr Pro Asn Leu 
385                 390                 395                 400 


Ile Phe Ser Asp Asp Leu Lys Ser Val Arg Leu Gly Asn Lys Trp Glu 
                405                 410                 415     


Arg Leu Pro Asp Gly Pro Gln Arg Phe Asp Ser Cys Ile Ile Val Leu 
            420                 425                 430         


Gly Ser Pro Ser Phe Leu Ser Gly Arg Arg Tyr Trp Glu Val Glu Val 
        435                 440                 445             


Gly Asp Lys Thr Ala Trp Ile Leu Gly Ala Cys Lys Thr Ser Ile Ser 
    450                 455                 460                 


Arg Lys Gly Asn Met Thr Leu Ser Pro Glu Asn Gly Tyr Trp Val Val 
465                 470                 475                 480 


Ile Met Met Lys Glu Asn Glu Tyr Gln Ala Ser Ser Val Pro Pro Thr 
                485                 490                 495     


Arg Leu Leu Ile Lys Glu Pro Pro Lys Arg Val Gly Ile Phe Val Asp 
            500                 505                 510         


Tyr Arg Val Gly Ser Ile Ser Phe Tyr Asn Val Thr Ala Arg Ser His 
        515                 520                 525             


Ile Tyr Thr Phe Ala Ser Cys Ser Phe Ser Gly Pro Leu Gln Pro Ile 
    530                 535                 540                 


Phe Ser Pro Gly Thr Arg Asp Gly Gly Lys Asn Thr Ala Pro Leu Thr 
545                 550                 555                 560 


Ile Cys Pro Val Gly Gly Gln Gly Pro Asp 
                565                 570 


<210>  118
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pyrin Isoform 3

<400>  118

Met Ala Lys Thr Pro Ser Asp His Leu Leu Ser Thr Leu Glu Glu Leu 
1               5                   10                  15      


Val Pro Tyr Asp Phe Glu Lys Phe Lys Phe Lys Leu Gln Asn Thr Ser 
            20                  25                  30          


Val Gln Lys Glu His Ser Arg Ile Pro Arg Ser Gln Ile Gln Arg Ala 
        35                  40                  45              


Arg Pro Val Lys Met Ala Thr Leu Leu Val Thr Tyr Tyr Gly Glu Glu 
    50                  55                  60                  


Tyr Ala Val Gln Leu Thr Leu Gln Val Leu Arg Ala Ile Asn Gln Arg 
65                  70                  75                  80  


Leu Leu Ala Glu Glu Leu His Arg Ala Ala Ile Gln Gly Arg Pro Pro 
                85                  90                  95      


Asp Thr Ala Ala Ser Pro Arg Cys His Ala Gln Glu Gly Asp Pro Val 
            100                 105                 110         


Asp Gly Thr Cys Val Arg Asp Ser Cys Ser Phe Pro Glu Ala Val Ser 
        115                 120                 125             


Gly His Pro Gln Ala Ser Gly Ser Arg Ser Pro Gly Cys Pro Arg Cys 
    130                 135                 140                 


Gln Asp Ser His Glu Arg Lys Ser Pro Gly Ser Leu Ser Pro Gln Pro 
145                 150                 155                 160 


Leu Pro Gln Cys Lys Arg His Leu Lys Gln Val Gln Leu Leu Phe Cys 
                165                 170                 175     


Glu Asp His Asp Glu Pro Ile Cys Leu Ile Cys Ser Leu Ser Gln Glu 
            180                 185                 190         


His Gln Gly His Arg Val Arg Pro Ile Glu Glu Val Ala Leu Glu His 
        195                 200                 205             


Lys Lys Lys Ile Gln Lys Gln Leu Glu His Leu Lys Lys Leu Arg Lys 
    210                 215                 220                 


Ser Gly Glu Glu Gln Arg Ser Tyr Gly Glu Glu Lys Ala Val Ser Phe 
225                 230                 235                 240 


Leu Lys Gln Thr Glu Ala Leu Lys Gln Arg Val Gln Arg Lys Leu Glu 
                245                 250                 255     


Gln Val Tyr Tyr Phe Leu Glu Gln Gln Glu His Phe Phe Val Ala Ser 
            260                 265                 270         


Leu Glu Asp Val Gly Gln Met Val Gly Gln Ile Arg Lys Ala Tyr Asp 
        275                 280                 285             


Thr Arg Val Ser Gln Asp Ile Ala Leu Leu Asp Ala Leu Ile Gly Glu 
    290                 295                 300                 


Leu Glu Ala Lys Glu Cys Gln Ser Glu Trp Glu Leu Leu Gln Asp Ile 
305                 310                 315                 320 


Gly Asp Ile Leu His Arg Ala Lys Thr Val Pro Val Pro Glu Lys Trp 
                325                 330                 335     


Thr Thr Pro Gln Glu Ile Lys Gln Lys Ile Gln Leu Leu His Gln Lys 
            340                 345                 350         


Ser Glu Phe Val Glu Lys Ser Thr Lys Tyr Phe Ser Glu Thr Leu Arg 
        355                 360                 365             


Ser Glu Met Glu Met Phe Asn Asp His Ser Pro Gln His Gly Leu Gly 
    370                 375                 380                 


Ser Trp Glu Glu Arg Asp Tyr Thr Gln His Ser Met Gln Gly Pro Lys 
385                 390                 395                 400 


Gln Gly Val Pro Cys Leu Ser Leu Leu Ser Gly Gln Cys Asn Leu Ala 
                405                 410                 415     


Pro Leu Asn Ala Asn Ala Gln Asp Phe Phe Pro Tyr Leu Ile Phe Leu 
            420                 425                 430         


Arg Ser Ser Gly Ala Asp Trp Arg Ser Gly Thr Cys Cys 
        435                 440                 445 


<210>  119
<211>  0
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  119
000

<210>  120
<211>  0
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  120
000

<210>  121
<211>  0
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  121
000

<210>  122
<211>  0
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  122
000

<210>  123
<211>  1036
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP3 Isoform 2

<400>  123

Met Lys Met Ala Ser Thr Arg Cys Lys Leu Ala Arg Tyr Leu Glu Asp 
1               5                   10                  15      


Leu Glu Asp Val Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
            20                  25                  30          


Pro Pro Gln Lys Gly Cys Ile Pro Leu Pro Arg Gly Gln Thr Glu Lys 
        35                  40                  45              


Ala Asp His Val Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu 
    50                  55                  60                  


Glu Lys Ala Trp Ala Met Ala Val Trp Ile Phe Ala Ala Ile Asn Arg 
65                  70                  75                  80  


Arg Asp Leu Tyr Glu Lys Ala Lys Arg Asp Glu Pro Lys Trp Gly Ser 
                85                  90                  95      


Asp Asn Ala Arg Val Ser Asn Pro Thr Val Ile Cys Gln Glu Asp Ser 
            100                 105                 110         


Ile Glu Glu Glu Trp Met Gly Leu Leu Glu Tyr Leu Ser Arg Ile Ser 
        115                 120                 125             


Ile Cys Lys Met Lys Lys Asp Tyr Arg Lys Lys Tyr Arg Lys Tyr Val 
    130                 135                 140                 


Arg Ser Arg Phe Gln Cys Ile Glu Asp Arg Asn Ala Arg Leu Gly Glu 
145                 150                 155                 160 


Ser Val Ser Leu Asn Lys Arg Tyr Thr Arg Leu Arg Leu Ile Lys Glu 
                165                 170                 175     


His Arg Ser Gln Gln Glu Arg Glu Gln Glu Leu Leu Ala Ile Gly Lys 
            180                 185                 190         


Thr Lys Thr Cys Glu Ser Pro Val Ser Pro Ile Lys Met Glu Leu Leu 
        195                 200                 205             


Phe Asp Pro Asp Asp Glu His Ser Glu Pro Val His Thr Val Val Phe 
    210                 215                 220                 


Gln Gly Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Met Met 
225                 230                 235                 240 


Leu Asp Trp Ala Ser Gly Thr Leu Tyr Gln Asp Arg Phe Asp Tyr Leu 
                245                 250                 255     


Phe Tyr Ile His Cys Arg Glu Val Ser Leu Val Thr Gln Arg Ser Leu 
            260                 265                 270         


Gly Asp Leu Ile Met Ser Cys Cys Pro Asp Pro Asn Pro Pro Ile His 
        275                 280                 285             


Lys Ile Val Arg Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe 
    290                 295                 300                 


Asp Glu Leu Gln Gly Ala Phe Asp Glu His Ile Gly Pro Leu Cys Thr 
305                 310                 315                 320 


Asp Trp Gln Lys Ala Glu Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile 
                325                 330                 335     


Arg Lys Lys Leu Leu Pro Glu Ala Ser Leu Leu Ile Thr Thr Arg Pro 
            340                 345                 350         


Val Ala Leu Glu Lys Leu Gln His Leu Leu Asp His Pro Arg His Val 
        355                 360                 365             


Glu Ile Leu Gly Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys 
    370                 375                 380                 


Tyr Phe Ser Asp Glu Ala Gln Ala Arg Ala Ala Phe Ser Leu Ile Gln 
385                 390                 395                 400 


Glu Asn Glu Val Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp 
                405                 410                 415     


Ile Val Cys Thr Gly Leu Lys Gln Gln Met Glu Ser Gly Lys Ser Leu 
            420                 425                 430         


Ala Gln Thr Ser Lys Thr Thr Thr Ala Val Tyr Val Phe Phe Leu Ser 
        435                 440                 445             


Ser Leu Leu Gln Pro Arg Gly Gly Ser Gln Glu His Gly Leu Cys Ala 
    450                 455                 460                 


His Leu Trp Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln 
465                 470                 475                 480 


Lys Ile Leu Phe Glu Glu Ser Asp Leu Arg Asn His Gly Leu Gln Lys 
                485                 490                 495     


Ala Asp Val Ser Ala Phe Leu Arg Met Asn Leu Phe Gln Lys Glu Val 
            500                 505                 510         


Asp Cys Glu Lys Phe Tyr Ser Phe Ile His Met Thr Phe Gln Glu Phe 
        515                 520                 525             


Phe Ala Ala Met Tyr Tyr Leu Leu Glu Glu Glu Lys Glu Gly Arg Thr 
    530                 535                 540                 


Asn Val Pro Gly Ser Arg Leu Lys Leu Pro Ser Arg Asp Val Thr Val 
545                 550                 555                 560 


Leu Leu Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val 
                565                 570                 575     


Val Arg Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu 
            580                 585                 590         


Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Ile Arg Leu Glu Leu 
        595                 600                 605             


Leu Lys Trp Ile Glu Val Lys Ala Lys Ala Lys Lys Leu Gln Ile Gln 
    610                 615                 620                 


Pro Ser Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu 
625                 630                 635                 640 


Asp Phe Val Gln Arg Ala Met Asp Tyr Phe Pro Lys Ile Glu Ile Asn 
                645                 650                 655     


Leu Ser Thr Arg Met Asp His Met Val Ser Ser Phe Cys Ile Glu Asn 
            660                 665                 670         


Cys His Arg Val Glu Ser Leu Ser Leu Gly Phe Leu His Asn Met Pro 
        675                 680                 685             


Lys Glu Glu Glu Glu Glu Glu Lys Glu Gly Arg His Leu Asp Met Val 
    690                 695                 700                 


Gln Cys Val Leu Pro Ser Ser Ser His Ala Ala Cys Ser His Gly Leu 
705                 710                 715                 720 


Val Asn Ser His Leu Thr Ser Ser Phe Cys Arg Gly Leu Phe Ser Val 
                725                 730                 735     


Leu Ser Thr Ser Gln Ser Leu Thr Glu Leu Asp Leu Ser Asp Asn Ser 
            740                 745                 750         


Leu Gly Asp Pro Gly Met Arg Val Leu Cys Glu Thr Leu Gln His Pro 
        755                 760                 765             


Gly Cys Asn Ile Arg Arg Leu Trp Leu Gly Arg Cys Gly Leu Ser His 
    770                 775                 780                 


Glu Cys Cys Phe Asp Ile Ser Leu Val Leu Ser Ser Asn Gln Lys Leu 
785                 790                 795                 800 


Val Glu Leu Asp Leu Ser Asp Asn Ala Leu Gly Asp Phe Gly Ile Arg 
                805                 810                 815     


Leu Leu Cys Val Gly Leu Lys His Leu Leu Cys Asn Leu Lys Lys Leu 
            820                 825                 830         


Trp Leu Val Ser Cys Cys Leu Thr Ser Ala Cys Cys Gln Asp Leu Ala 
        835                 840                 845             


Ser Val Leu Ser Thr Ser His Ser Leu Thr Arg Leu Tyr Val Gly Glu 
    850                 855                 860                 


Asn Ala Leu Gly Asp Ser Gly Val Ala Ile Leu Cys Glu Lys Ala Lys 
865                 870                 875                 880 


Asn Pro Gln Cys Asn Leu Gln Lys Leu Gly Leu Val Asn Ser Gly Leu 
                885                 890                 895     


Thr Ser Val Cys Cys Ser Ala Leu Ser Ser Val Leu Ser Thr Asn Gln 
            900                 905                 910         


Asn Leu Thr His Leu Tyr Leu Arg Gly Asn Thr Leu Gly Asp Lys Gly 
        915                 920                 925             


Ile Lys Leu Leu Cys Glu Gly Leu Leu His Pro Asp Cys Lys Leu Gln 
    930                 935                 940                 


Val Leu Glu Leu Asp Asn Cys Asn Leu Thr Ser His Cys Cys Trp Asp 
945                 950                 955                 960 


Leu Ser Thr Leu Leu Thr Ser Ser Gln Ser Leu Arg Lys Leu Ser Leu 
                965                 970                 975     


Gly Asn Asn Asp Leu Gly Asp Leu Gly Val Met Met Phe Cys Glu Val 
            980                 985                 990         


Leu Lys Gln Gln Ser Cys Leu Leu  Gln Asn Leu Gly Leu  Ser Glu Met 
        995                 1000                 1005             


Tyr Phe  Asn Tyr Glu Thr Lys  Ser Ala Leu Glu Thr  Leu Gln Glu 
    1010                 1015                 1020             


Glu Lys  Pro Glu Leu Thr Val  Val Phe Glu Pro Ser  Trp 
    1025                 1030                 1035     


<210>  124
<211>  922
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP3 Isoform 1

<400>  124

Met Lys Met Ala Ser Thr Arg Cys Lys Leu Ala Arg Tyr Leu Glu Asp 
1               5                   10                  15      


Leu Glu Asp Val Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
            20                  25                  30          


Pro Pro Gln Lys Gly Cys Ile Pro Leu Pro Arg Gly Gln Thr Glu Lys 
        35                  40                  45              


Ala Asp His Val Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu 
    50                  55                  60                  


Glu Lys Ala Trp Ala Met Ala Val Trp Ile Phe Ala Ala Ile Asn Arg 
65                  70                  75                  80  


Arg Asp Leu Tyr Glu Lys Ala Lys Arg Asp Glu Pro Lys Trp Gly Ser 
                85                  90                  95      


Asp Asn Ala Arg Val Ser Asn Pro Thr Val Ile Cys Gln Glu Asp Ser 
            100                 105                 110         


Ile Glu Glu Glu Trp Met Gly Leu Leu Glu Tyr Leu Ser Arg Ile Ser 
        115                 120                 125             


Ile Cys Lys Met Lys Lys Asp Tyr Arg Lys Lys Tyr Arg Lys Tyr Val 
    130                 135                 140                 


Arg Ser Arg Phe Gln Cys Ile Glu Asp Arg Asn Ala Arg Leu Gly Glu 
145                 150                 155                 160 


Ser Val Ser Leu Asn Lys Arg Tyr Thr Arg Leu Arg Leu Ile Lys Glu 
                165                 170                 175     


His Arg Ser Gln Gln Glu Arg Glu Gln Glu Leu Leu Ala Ile Gly Lys 
            180                 185                 190         


Thr Lys Thr Cys Glu Ser Pro Val Ser Pro Ile Lys Met Glu Leu Leu 
        195                 200                 205             


Phe Asp Pro Asp Asp Glu His Ser Glu Pro Val His Thr Val Val Phe 
    210                 215                 220                 


Gln Gly Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Met Met 
225                 230                 235                 240 


Leu Asp Trp Ala Ser Gly Thr Leu Tyr Gln Asp Arg Phe Asp Tyr Leu 
                245                 250                 255     


Phe Tyr Ile His Cys Arg Glu Val Ser Leu Val Thr Gln Arg Ser Leu 
            260                 265                 270         


Gly Asp Leu Ile Met Ser Cys Cys Pro Asp Pro Asn Pro Pro Ile His 
        275                 280                 285             


Lys Ile Val Arg Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe 
    290                 295                 300                 


Asp Glu Leu Gln Gly Ala Phe Asp Glu His Ile Gly Pro Leu Cys Thr 
305                 310                 315                 320 


Asp Trp Gln Lys Ala Glu Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile 
                325                 330                 335     


Arg Lys Lys Leu Leu Pro Glu Ala Ser Leu Leu Ile Thr Thr Arg Pro 
            340                 345                 350         


Val Ala Leu Glu Lys Leu Gln His Leu Leu Asp His Pro Arg His Val 
        355                 360                 365             


Glu Ile Leu Gly Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys 
    370                 375                 380                 


Tyr Phe Ser Asp Glu Ala Gln Ala Arg Ala Ala Phe Ser Leu Ile Gln 
385                 390                 395                 400 


Glu Asn Glu Val Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp 
                405                 410                 415     


Ile Val Cys Thr Gly Leu Lys Gln Gln Met Glu Ser Gly Lys Ser Leu 
            420                 425                 430         


Ala Gln Thr Ser Lys Thr Thr Thr Ala Val Tyr Val Phe Phe Leu Ser 
        435                 440                 445             


Ser Leu Leu Gln Pro Arg Gly Gly Ser Gln Glu His Gly Leu Cys Ala 
    450                 455                 460                 


His Leu Trp Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln 
465                 470                 475                 480 


Lys Ile Leu Phe Glu Glu Ser Asp Leu Arg Asn His Gly Leu Gln Lys 
                485                 490                 495     


Ala Asp Val Ser Ala Phe Leu Arg Met Asn Leu Phe Gln Lys Glu Val 
            500                 505                 510         


Asp Cys Glu Lys Phe Tyr Ser Phe Ile His Met Thr Phe Gln Glu Phe 
        515                 520                 525             


Phe Ala Ala Met Tyr Tyr Leu Leu Glu Glu Glu Lys Glu Gly Arg Thr 
    530                 535                 540                 


Asn Val Pro Gly Ser Arg Leu Lys Leu Pro Ser Arg Asp Val Thr Val 
545                 550                 555                 560 


Leu Leu Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val 
                565                 570                 575     


Val Arg Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu 
            580                 585                 590         


Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Ile Arg Leu Glu Leu 
        595                 600                 605             


Leu Lys Trp Ile Glu Val Lys Ala Lys Ala Lys Lys Leu Gln Ile Gln 
    610                 615                 620                 


Pro Ser Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu 
625                 630                 635                 640 


Asp Phe Val Gln Arg Ala Met Asp Tyr Phe Pro Lys Ile Glu Ile Asn 
                645                 650                 655     


Leu Ser Thr Arg Met Asp His Met Val Ser Ser Phe Cys Ile Glu Asn 
            660                 665                 670         


Cys His Arg Val Glu Ser Leu Ser Leu Gly Phe Leu His Asn Met Pro 
        675                 680                 685             


Lys Glu Glu Glu Glu Glu Glu Lys Glu Gly Arg His Leu Asp Met Val 
    690                 695                 700                 


Gln Cys Val Leu Pro Ser Ser Ser His Ala Ala Cys Ser His Gly Leu 
705                 710                 715                 720 


Gly Arg Cys Gly Leu Ser His Glu Cys Cys Phe Asp Ile Ser Leu Val 
                725                 730                 735     


Leu Ser Ser Asn Gln Lys Leu Val Glu Leu Asp Leu Ser Asp Asn Ala 
            740                 745                 750         


Leu Gly Asp Phe Gly Ile Arg Leu Leu Cys Val Gly Leu Lys His Leu 
        755                 760                 765             


Leu Cys Asn Leu Lys Lys Leu Trp Leu Val Asn Ser Gly Leu Thr Ser 
    770                 775                 780                 


Val Cys Cys Ser Ala Leu Ser Ser Val Leu Ser Thr Asn Gln Asn Leu 
785                 790                 795                 800 


Thr His Leu Tyr Leu Arg Gly Asn Thr Leu Gly Asp Lys Gly Ile Lys 
                805                 810                 815     


Leu Leu Cys Glu Gly Leu Leu His Pro Asp Cys Lys Leu Gln Val Leu 
            820                 825                 830         


Glu Leu Asp Asn Cys Asn Leu Thr Ser His Cys Cys Trp Asp Leu Ser 
        835                 840                 845             


Thr Leu Leu Thr Ser Ser Gln Ser Leu Arg Lys Leu Ser Leu Gly Asn 
    850                 855                 860                 


Asn Asp Leu Gly Asp Leu Gly Val Met Met Phe Cys Glu Val Leu Lys 
865                 870                 875                 880 


Gln Gln Ser Cys Leu Leu Gln Asn Leu Gly Leu Ser Glu Met Tyr Phe 
                885                 890                 895     


Asn Tyr Glu Thr Lys Ser Ala Leu Glu Thr Leu Gln Glu Glu Lys Pro 
            900                 905                 910         


Glu Leu Thr Val Val Phe Glu Pro Ser Trp 
        915                 920         


<210>  125
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP3 Isoform 3

<400>  125

Met Lys Met Ala Ser Thr Arg Cys Lys Leu Ala Arg Tyr Leu Glu Asp 
1               5                   10                  15      


Leu Glu Asp Val Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
            20                  25                  30          


Pro Pro Gln Lys Gly Cys Ile Pro Leu Pro Arg Gly Gln Thr Glu Lys 
        35                  40                  45              


Ala Asp His Val Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu 
    50                  55                  60                  


Glu Lys Ala Trp Ala Met Ala Val Trp Ile Phe Ala Ala Ile Asn Arg 
65                  70                  75                  80  


Arg Asp Leu Tyr Glu Lys Ala Lys Arg Asp Glu Pro Lys Trp Gly Ser 
                85                  90                  95      


Asp Asn Ala Arg Val Ser Asn Pro Thr Val Ile Cys Gln Glu Asp Ser 
            100                 105                 110         


Ile Glu Glu Glu Trp Met Gly Leu Leu Glu Tyr Leu Ser Arg Ile Ser 
        115                 120                 125             


Ile Cys Lys Met Lys Lys Asp Tyr Arg Lys Lys Tyr Arg Lys Tyr Val 
    130                 135                 140                 


Arg Ser Arg Phe Gln Cys Ile Glu Asp Arg Asn Ala Arg Leu Gly Glu 
145                 150                 155                 160 


Ser Val Ser Leu Asn Lys Arg Tyr Thr Arg Leu Arg Leu Ile Lys Glu 
                165                 170                 175     


His Arg Ser Gln Gln Glu Arg Glu Gln Glu Leu Leu Ala Ile Gly Lys 
            180                 185                 190         


Thr Lys Thr Cys Glu Ser Pro Val Ser Pro Ile Lys Met Glu Leu Leu 
        195                 200                 205             


Phe Asp Pro Asp Asp Glu His Ser Glu Pro Val His Thr Val Val Phe 
    210                 215                 220                 


Gln Gly Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Met Met 
225                 230                 235                 240 


Leu Asp Trp Ala Ser Gly Thr Leu Tyr Gln Asp Arg Phe Asp Tyr Leu 
                245                 250                 255     


Phe Tyr Ile His Cys Arg Glu Val Ser Leu Val Thr Gln Arg Ser Leu 
            260                 265                 270         


Gly Asp Leu Ile Met Ser Cys Cys Pro Asp Pro Asn Pro Pro Ile His 
        275                 280                 285             


Lys Ile Val Arg Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe 
    290                 295                 300                 


Asp Glu Leu Gln Gly Ala Phe Asp Glu His Ile Gly Pro Leu Cys Thr 
305                 310                 315                 320 


Asp Trp Gln Lys Ala Glu Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile 
                325                 330                 335     


Arg Lys Lys Leu Leu Pro Glu Ala Ser Leu Leu Ile Thr Thr Arg Pro 
            340                 345                 350         


Val Ala Leu Glu Lys Leu Gln His Leu Leu Asp His Pro Arg His Val 
        355                 360                 365             


Glu Ile Leu Gly Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys 
    370                 375                 380                 


Tyr Phe Ser Asp Glu Ala Gln Ala Arg Ala Ala Phe Ser Leu Ile Gln 
385                 390                 395                 400 


Glu Asn Glu Val Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp 
                405                 410                 415     


Ile Val Cys Thr Gly Leu Lys Gln Gln Met Glu Ser Gly Lys Ser Leu 
            420                 425                 430         


Ala Gln Thr Ser Lys Thr Thr Thr Ala Val Tyr Val Phe Phe Leu Ser 
        435                 440                 445             


Ser Leu Leu Gln Pro Arg Gly Gly Ser Gln Glu His Gly Leu Cys Ala 
    450                 455                 460                 


His Leu Trp Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln 
465                 470                 475                 480 


Lys Ile Leu Phe Glu Glu Ser Asp Leu Arg Asn His Gly Leu Gln Lys 
                485                 490                 495     


Ala Asp Val Ser Ala Phe Leu Arg Met Asn Leu Phe Gln Lys Glu Val 
            500                 505                 510         


Asp Cys Glu Lys Phe Tyr Ser Phe Ile His Met Thr Phe Gln Glu Phe 
        515                 520                 525             


Phe Ala Ala Met Tyr Tyr Leu Leu Glu Glu Glu Lys Glu Gly Arg Thr 
    530                 535                 540                 


Asn Val Pro Gly Ser Arg Leu Lys Leu Pro Ser Arg Asp Val Thr Val 
545                 550                 555                 560 


Leu Leu Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val 
                565                 570                 575     


Val Arg Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu 
            580                 585                 590         


Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Ile Arg Leu Glu Leu 
        595                 600                 605             


Leu Lys Trp Ile Glu Val Lys Ala Lys Ala Lys Lys Leu Gln Ile Gln 
    610                 615                 620                 


Pro Ser Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu 
625                 630                 635                 640 


Asp Phe Val Gln Arg Ala Met Asp Tyr Phe Pro Lys Ile Glu Ile Asn 
                645                 650                 655     


Leu Ser Thr Arg Met Asp His Met Val Ser Ser Phe Cys Ile Glu Asn 
            660                 665                 670         


Cys His Arg Val Glu Ser Leu Ser Leu Gly Phe Leu His Asn Met Pro 
        675                 680                 685             


Lys Glu Glu Glu Glu Glu Glu Lys Glu Gly Arg His Leu Asp Met Val 
    690                 695                 700                 


Gln Cys Val Leu Pro Ser Ser Ser His Ala Ala Cys Ser His Gly 
705                 710                 715                 


<210>  126
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP3 Isoform 4

<400>  126

Met Lys Met Ala Ser Thr Arg Cys Lys Leu Ala Arg Tyr Leu Glu Asp 
1               5                   10                  15      


Leu Glu Asp Val Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
            20                  25                  30          


Pro Pro Gln Lys Gly Cys Ile Pro Leu Pro Arg Gly Gln Thr Glu Lys 
        35                  40                  45              


Ala Asp His Val Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu 
    50                  55                  60                  


Glu Lys Ala Trp Ala Met Ala Val Trp Ile Phe Ala Ala Ile Asn Arg 
65                  70                  75                  80  


Arg Asp Leu Tyr Glu Lys Ala Lys Arg Asp Glu Pro Lys Trp Gly Ser 
                85                  90                  95      


Asp Asn Ala Arg Val Ser Asn Pro Thr Val Ile Cys Gln Glu Asp Ser 
            100                 105                 110         


Ile Glu Glu Glu Trp Met Gly Leu Leu Glu Tyr Leu Ser Arg Ile Ser 
        115                 120                 125             


Ile Cys Lys Met Lys Lys Asp Tyr Arg Lys Lys Tyr Arg Lys Tyr Val 
    130                 135                 140                 


Arg Ser Arg Phe Gln Cys Ile Glu Asp Arg Asn Ala Arg Leu Gly Glu 
145                 150                 155                 160 


Ser Val Ser Leu Asn Lys Arg Tyr Thr Arg Leu Arg Leu Ile Lys Glu 
                165                 170                 175     


His Arg Ser Gln Gln Glu Arg Glu Gln Glu Leu Leu Ala Ile Gly Lys 
            180                 185                 190         


Thr Lys Thr Cys Glu Ser Pro Val Ser Pro Ile Lys Met Glu Leu Leu 
        195                 200                 205             


Phe Asp Pro Asp Asp Glu His Ser Glu Pro Val His Thr Val Val Phe 
    210                 215                 220                 


Gln Gly Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Met Met 
225                 230                 235                 240 


Leu Asp Trp Ala Ser Gly Thr Leu Tyr Gln Asp Arg Phe Asp Tyr Leu 
                245                 250                 255     


Phe Tyr Ile His Cys Arg Glu Val Ser Leu Val Thr Gln Arg Ser Leu 
            260                 265                 270         


Gly Asp Leu Ile Met Ser Cys Cys Pro Asp Pro Asn Pro Pro Ile His 
        275                 280                 285             


Lys Ile Val Arg Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe 
    290                 295                 300                 


Asp Glu Leu Gln Gly Ala Phe Asp Glu His Ile Gly Pro Leu Cys Thr 
305                 310                 315                 320 


Asp Trp Gln Lys Ala Glu Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile 
                325                 330                 335     


Arg Lys Lys Leu Leu Pro Glu Ala Ser Leu Leu Ile Thr Thr Arg Pro 
            340                 345                 350         


Val Ala Leu Glu Lys Leu Gln His Leu Leu Asp His Pro Arg His Val 
        355                 360                 365             


Glu Ile Leu Gly Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys 
    370                 375                 380                 


Tyr Phe Ser Asp Glu Ala Gln Ala Arg Ala Ala Phe Ser Leu Ile Gln 
385                 390                 395                 400 


Glu Asn Glu Val Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp 
                405                 410                 415     


Ile Val Cys Thr Gly Leu Lys Gln Gln Met Glu Ser Gly Lys Ser Leu 
            420                 425                 430         


Ala Gln Thr Ser Lys Thr Thr Thr Ala Val Tyr Val Phe Phe Leu Ser 
        435                 440                 445             


Ser Leu Leu Gln Pro Arg Gly Gly Ser Gln Glu His Gly Leu Cys Ala 
    450                 455                 460                 


His Leu Trp Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln 
465                 470                 475                 480 


Lys Ile Leu Phe Glu Glu Ser Asp Leu Arg Asn His Gly Leu Gln Lys 
                485                 490                 495     


Ala Asp Val Ser Ala Phe Leu Arg Met Asn Leu Phe Gln Lys Glu Val 
            500                 505                 510         


Asp Cys Glu Lys Phe Tyr Ser Phe Ile His Met Thr Phe Gln Glu Phe 
        515                 520                 525             


Phe Ala Ala Met Tyr Tyr Leu Leu Glu Glu Glu Lys Glu Gly Arg Thr 
    530                 535                 540                 


Asn Val Pro Gly Ser Arg Leu Lys Leu Pro Ser Arg Asp Val Thr Val 
545                 550                 555                 560 


Leu Leu Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val 
                565                 570                 575     


Val Arg Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu 
            580                 585                 590         


Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Ile Arg Leu Glu Leu 
        595                 600                 605             


Leu Lys Trp Ile Glu Val Lys Ala Lys Ala Lys Lys Leu Gln Ile Gln 
    610                 615                 620                 


Pro Ser Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu 
625                 630                 635                 640 


Asp Phe Val Gln Arg Ala Met Asp Tyr Phe Pro Lys Ile Glu Ile Asn 
                645                 650                 655     


Leu Ser Thr Arg Met Asp His Met Val Ser Ser Phe Cys Ile Glu Asn 
            660                 665                 670         


Cys His Arg Val Glu Ser Leu Ser Leu Gly Phe Leu His Asn Met Pro 
        675                 680                 685             


Lys Glu Glu Glu Glu Glu Glu Lys Glu Gly Arg His Leu Asp Met Val 
    690                 695                 700                 


Gln Cys Val Leu Pro Ser Ser Ser His Ala Ala Cys Ser His Gly Leu 
705                 710                 715                 720 


Gly Arg Cys Gly Leu Ser His Glu Cys Cys Phe Asp Ile Ser Leu Val 
                725                 730                 735     


Leu Ser Ser Asn Gln Lys Leu Val Glu Leu Asp Leu Ser Asp Asn Ala 
            740                 745                 750         


Leu Gly Asp Phe Gly Ile Arg Leu Leu Cys Val Gly Leu Lys His Leu 
        755                 760                 765             


Leu Cys Asn Leu Lys Lys Leu Trp Leu Val Ser Cys Cys Leu Thr Ser 
    770                 775                 780                 


Ala Cys Cys Gln Asp Leu Ala Ser Val Leu Ser Thr Ser His Ser Leu 
785                 790                 795                 800 


Thr Arg Leu Tyr Val Gly Glu Asn Ala Leu Gly Asp Ser Gly Val Ala 
                805                 810                 815     


Ile Leu Cys Glu Lys Ala Lys Asn Pro Gln Cys Asn Leu Gln Lys Leu 
            820                 825                 830         


Gly Leu Val Asn Ser Gly Leu Thr Ser Val Cys Cys Ser Ala Leu Ser 
        835                 840                 845             


Ser Val Leu Ser Thr Asn Gln Asn Leu Thr His Leu Tyr Leu Arg Gly 
    850                 855                 860                 


Asn Thr Leu Gly Asp Lys Gly Ile Lys Leu Leu Cys Glu Gly Leu Leu 
865                 870                 875                 880 


His Pro Asp Cys Lys Leu Gln Val Leu Glu Leu Asp Asn Cys Asn Leu 
                885                 890                 895     


Thr Ser His Cys Cys Trp Asp Leu Ser Thr Leu Leu Thr Ser Ser Gln 
            900                 905                 910         


Ser Leu Arg Lys Leu Ser Leu Gly Asn Asn Asp Leu Gly Asp Leu Gly 
        915                 920                 925             


Val Met Met Phe Cys Glu Val Leu Lys Gln Gln Ser Cys Leu Leu Gln 
    930                 935                 940                 


Asn Leu Gly Leu Ser Glu Met Tyr Phe Asn Tyr Glu Thr Lys Ser Ala 
945                 950                 955                 960 


Leu Glu Thr Leu Gln Glu Glu Lys Pro Glu Leu Thr Val Val Phe Glu 
                965                 970                 975     


Pro Ser Trp 
            


<210>  127
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP3 Isoform 5

<400>  127

Met Lys Met Ala Ser Thr Arg Cys Lys Leu Ala Arg Tyr Leu Glu Asp 
1               5                   10                  15      


Leu Glu Asp Val Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
            20                  25                  30          


Pro Pro Gln Lys Gly Cys Ile Pro Leu Pro Arg Gly Gln Thr Glu Lys 
        35                  40                  45              


Ala Asp His Val Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu 
    50                  55                  60                  


Glu Lys Ala Trp Ala Met Ala Val Trp Ile Phe Ala Ala Ile Asn Arg 
65                  70                  75                  80  


Arg Asp Leu Tyr Glu Lys Ala Lys Arg Asp Glu Pro Lys Trp Gly Ser 
                85                  90                  95      


Asp Asn Ala Arg Val Ser Asn Pro Thr Val Ile Cys Gln Glu Asp Ser 
            100                 105                 110         


Ile Glu Glu Glu Trp Met Gly Leu Leu Glu Tyr Leu Ser Arg Ile Ser 
        115                 120                 125             


Ile Cys Lys Met Lys Lys Asp Tyr Arg Lys Lys Tyr Arg Lys Tyr Val 
    130                 135                 140                 


Arg Ser Arg Phe Gln Cys Ile Glu Asp Arg Asn Ala Arg Leu Gly Glu 
145                 150                 155                 160 


Ser Val Ser Leu Asn Lys Arg Tyr Thr Arg Leu Arg Leu Ile Lys Glu 
                165                 170                 175     


His Arg Ser Gln Gln Glu Arg Glu Gln Glu Leu Leu Ala Ile Gly Lys 
            180                 185                 190         


Thr Lys Thr Cys Glu Ser Pro Val Ser Pro Ile Lys Met Glu Leu Leu 
        195                 200                 205             


Phe Asp Pro Asp Asp Glu His Ser Glu Pro Val His Thr Val Val Phe 
    210                 215                 220                 


Gln Gly Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Met Met 
225                 230                 235                 240 


Leu Asp Trp Ala Ser Gly Thr Leu Tyr Gln Asp Arg Phe Asp Tyr Leu 
                245                 250                 255     


Phe Tyr Ile His Cys Arg Glu Val Ser Leu Val Thr Gln Arg Ser Leu 
            260                 265                 270         


Gly Asp Leu Ile Met Ser Cys Cys Pro Asp Pro Asn Pro Pro Ile His 
        275                 280                 285             


Lys Ile Val Arg Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe 
    290                 295                 300                 


Asp Glu Leu Gln Gly Ala Phe Asp Glu His Ile Gly Pro Leu Cys Thr 
305                 310                 315                 320 


Asp Trp Gln Lys Ala Glu Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile 
                325                 330                 335     


Arg Lys Lys Leu Leu Pro Glu Ala Ser Leu Leu Ile Thr Thr Arg Pro 
            340                 345                 350         


Val Ala Leu Glu Lys Leu Gln His Leu Leu Asp His Pro Arg His Val 
        355                 360                 365             


Glu Ile Leu Gly Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys 
    370                 375                 380                 


Tyr Phe Ser Asp Glu Ala Gln Ala Arg Ala Ala Phe Ser Leu Ile Gln 
385                 390                 395                 400 


Glu Asn Glu Val Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp 
                405                 410                 415     


Ile Val Cys Thr Gly Leu Lys Gln Gln Met Glu Ser Gly Lys Ser Leu 
            420                 425                 430         


Ala Gln Thr Ser Lys Thr Thr Thr Ala Val Tyr Val Phe Phe Leu Ser 
        435                 440                 445             


Ser Leu Leu Gln Pro Arg Gly Gly Ser Gln Glu His Gly Leu Cys Ala 
    450                 455                 460                 


His Leu Trp Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln 
465                 470                 475                 480 


Lys Ile Leu Phe Glu Glu Ser Asp Leu Arg Asn His Gly Leu Gln Lys 
                485                 490                 495     


Ala Asp Val Ser Ala Phe Leu Arg Met Asn Leu Phe Gln Lys Glu Val 
            500                 505                 510         


Asp Cys Glu Lys Phe Tyr Ser Phe Ile His Met Thr Phe Gln Glu Phe 
        515                 520                 525             


Phe Ala Ala Met Tyr Tyr Leu Leu Glu Glu Glu Lys Glu Gly Arg Thr 
    530                 535                 540                 


Asn Val Pro Gly Ser Arg Leu Lys Leu Pro Ser Arg Asp Val Thr Val 
545                 550                 555                 560 


Leu Leu Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val 
                565                 570                 575     


Val Arg Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu 
            580                 585                 590         


Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Ile Arg Leu Glu Leu 
        595                 600                 605             


Leu Lys Trp Ile Glu Val Lys Ala Lys Ala Lys Lys Leu Gln Ile Gln 
    610                 615                 620                 


Pro Ser Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu 
625                 630                 635                 640 


Asp Phe Val Gln Arg Ala Met Asp Tyr Phe Pro Lys Ile Glu Ile Asn 
                645                 650                 655     


Leu Ser Thr Arg Met Asp His Met Val Ser Ser Phe Cys Ile Glu Asn 
            660                 665                 670         


Cys His Arg Val Glu Ser Leu Ser Leu Gly Phe Leu His Asn Met Pro 
        675                 680                 685             


Lys Glu Glu Glu Glu Glu Glu Lys Glu Gly Arg His Leu Asp Met Val 
    690                 695                 700                 


Gln Cys Val Leu Pro Ser Ser Ser His Ala Ala Cys Ser His Gly Leu 
705                 710                 715                 720 


Val Asn Ser His Leu Thr Ser Ser Phe Cys Arg Gly Leu Phe Ser Val 
                725                 730                 735     


Leu Ser Thr Ser Gln Ser Leu Thr Glu Leu Asp Leu Ser Asp Asn Ser 
            740                 745                 750         


Leu Gly Asp Pro Gly Met Arg Val Leu Cys Glu Thr Leu Gln His Pro 
        755                 760                 765             


Gly Cys Asn Ile Arg Arg Leu Trp Leu Gly Arg Cys Gly Leu Ser His 
    770                 775                 780                 


Glu Cys Cys Phe Asp Ile Ser Leu Val Leu Ser Ser Asn Gln Lys Leu 
785                 790                 795                 800 


Val Glu Leu Asp Leu Ser Asp Asn Ala Leu Gly Asp Phe Gly Ile Arg 
                805                 810                 815     


Leu Leu Cys Val Gly Leu Lys His Leu Leu Cys Asn Leu Lys Lys Leu 
            820                 825                 830         


Trp Leu Val Asn Ser Gly Leu Thr Ser Val Cys Cys Ser Ala Leu Ser 
        835                 840                 845             


Ser Val Leu Ser Thr Asn Gln Asn Leu Thr His Leu Tyr Leu Arg Gly 
    850                 855                 860                 


Asn Thr Leu Gly Asp Lys Gly Ile Lys Leu Leu Cys Glu Gly Leu Leu 
865                 870                 875                 880 


His Pro Asp Cys Lys Leu Gln Val Leu Glu Leu Asp Asn Cys Asn Leu 
                885                 890                 895     


Thr Ser His Cys Cys Trp Asp Leu Ser Thr Leu Leu Thr Ser Ser Gln 
            900                 905                 910         


Ser Leu Arg Lys Leu Ser Leu Gly Asn Asn Asp Leu Gly Asp Leu Gly 
        915                 920                 925             


Val Met Met Phe Cys Glu Val Leu Lys Gln Gln Ser Cys Leu Leu Gln 
    930                 935                 940                 


Asn Leu Gly Leu Ser Glu Met Tyr Phe Asn Tyr Glu Thr Lys Ser Ala 
945                 950                 955                 960 


Leu Glu Thr Leu Gln Glu Glu Lys Pro Glu Leu Thr Val Val Phe Glu 
                965                 970                 975     


Pro Ser Trp 
            


<210>  128
<211>  1016
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP3 Isoform 6

<400>  128

Met Lys Met Ala Ser Thr Arg Cys Lys Leu Ala Arg Tyr Leu Glu Asp 
1               5                   10                  15      


Leu Glu Asp Val Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
            20                  25                  30          


Pro Pro Gln Lys Gly Cys Ile Pro Leu Pro Arg Gly Gln Thr Glu Lys 
        35                  40                  45              


Ala Asp His Val Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu 
    50                  55                  60                  


Glu Lys Ala Trp Ala Met Ala Val Trp Ile Phe Ala Ala Ile Asn Arg 
65                  70                  75                  80  


Arg Asp Leu Tyr Glu Lys Ala Lys Arg Asp Glu Pro Lys Trp Gly Ser 
                85                  90                  95      


Asp Asn Ala Arg Val Ser Asn Pro Thr Val Ile Cys Gln Glu Asp Ser 
            100                 105                 110         


Ile Glu Glu Glu Trp Met Gly Leu Leu Glu Tyr Leu Ser Arg Ile Ser 
        115                 120                 125             


Ile Cys Lys Met Lys Lys Asp Tyr Arg Lys Lys Tyr Arg Lys Tyr Val 
    130                 135                 140                 


Arg Ser Arg Phe Gln Cys Ile Glu Asp Arg Asn Ala Arg Leu Gly Glu 
145                 150                 155                 160 


Ser Val Ser Leu Asn Lys Arg Tyr Thr Arg Leu Arg Leu Ile Lys Glu 
                165                 170                 175     


His Arg Ser Gln Gln Glu Arg Glu Gln Glu Leu Leu Ala Ile Gly Lys 
            180                 185                 190         


Thr Lys Thr Cys Glu Ser Pro Val Ser Pro Ile Lys Met Glu Leu Leu 
        195                 200                 205             


Phe Asp Pro Asp Asp Glu His Ser Glu Pro Val His Thr Val Val Phe 
    210                 215                 220                 


Gln Gly Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Met Met 
225                 230                 235                 240 


Leu Asp Trp Ala Ser Gly Thr Leu Tyr Gln Asp Arg Phe Asp Tyr Leu 
                245                 250                 255     


Phe Tyr Ile His Cys Arg Glu Val Ser Leu Val Thr Gln Arg Ser Leu 
            260                 265                 270         


Gly Asp Leu Ile Met Ser Cys Cys Pro Asp Pro Asn Pro Pro Ile His 
        275                 280                 285             


Lys Ile Val Arg Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe 
    290                 295                 300                 


Asp Glu Leu Gln Gly Ala Phe Asp Glu His Ile Gly Pro Leu Cys Thr 
305                 310                 315                 320 


Asp Trp Gln Lys Ala Glu Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile 
                325                 330                 335     


Arg Lys Lys Leu Leu Pro Glu Ala Ser Leu Leu Ile Thr Thr Arg Pro 
            340                 345                 350         


Val Ala Leu Glu Lys Leu Gln His Leu Leu Asp His Pro Arg His Val 
        355                 360                 365             


Glu Ile Leu Gly Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys 
    370                 375                 380                 


Tyr Phe Ser Asp Glu Ala Gln Ala Arg Ala Ala Phe Ser Leu Ile Gln 
385                 390                 395                 400 


Glu Asn Glu Val Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp 
                405                 410                 415     


Ile Val Cys Thr Gly Leu Lys Gln Gln Met Glu Ser Gly Lys Ser Leu 
            420                 425                 430         


Ala Gln Thr Ser Lys Thr Thr Thr Ala Val Tyr Val Phe Phe Leu Ser 
        435                 440                 445             


Ser Leu Leu Gln Pro Arg Gly Gly Ser Gln Glu His Gly Leu Cys Ala 
    450                 455                 460                 


His Leu Trp Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln 
465                 470                 475                 480 


Lys Ile Leu Phe Glu Glu Ser Asp Leu Arg Asn His Gly Leu Gln Lys 
                485                 490                 495     


Ala Asp Val Ser Ala Phe Leu Arg Met Asn Leu Phe Gln Lys Glu Val 
            500                 505                 510         


Asp Cys Glu Lys Phe Tyr Ser Phe Ile His Met Thr Phe Gln Glu Phe 
        515                 520                 525             


Phe Ala Ala Met Tyr Tyr Leu Leu Glu Glu Glu Lys Glu Gly Arg Thr 
    530                 535                 540                 


Asn Val Pro Gly Ser Arg Leu Lys Leu Pro Ser Arg Asp Val Thr Val 
545                 550                 555                 560 


Leu Leu Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val 
                565                 570                 575     


Val Arg Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu 
            580                 585                 590         


Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Ile Arg Leu Glu Leu 
        595                 600                 605             


Leu Lys Trp Ile Glu Val Lys Ala Lys Ala Lys Lys Leu Gln Ile Gln 
    610                 615                 620                 


Pro Ser Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu 
625                 630                 635                 640 


Asp Phe Val Gln Arg Ala Met Asp Tyr Phe Pro Lys Ile Glu Ile Asn 
                645                 650                 655     


Leu Ser Thr Arg Met Asp His Met Val Ser Ser Phe Cys Ile Glu Asn 
            660                 665                 670         


Cys His Arg Val Glu Ser Leu Ser Leu Gly Phe Leu His Asn Met Pro 
        675                 680                 685             


Lys Glu Glu Glu Glu Glu Glu Lys Glu Gly Arg His Leu Asp Met Val 
    690                 695                 700                 


Gln Cys Val Leu Pro Ser Ser Ser His Ala Ala Cys Ser His Gly Leu 
705                 710                 715                 720 


Val Asn Ser His Leu Thr Ser Ser Phe Cys Arg Gly Leu Phe Ser Val 
                725                 730                 735     


Leu Ser Thr Ser Gln Ser Leu Thr Glu Leu Asp Leu Ser Asp Asn Ser 
            740                 745                 750         


Leu Gly Asp Pro Gly Met Arg Val Leu Cys Glu Thr Leu Gln His Pro 
        755                 760                 765             


Gly Cys Asn Ile Arg Arg Leu Cys Asn Gln Lys Leu Val Glu Leu Asp 
    770                 775                 780                 


Leu Ser Asp Asn Ala Leu Gly Asp Phe Gly Ile Arg Leu Leu Cys Val 
785                 790                 795                 800 


Gly Leu Lys His Leu Leu Cys Asn Leu Lys Lys Leu Trp Leu Val Ser 
                805                 810                 815     


Cys Cys Leu Thr Ser Ala Cys Cys Gln Asp Leu Ala Ser Val Leu Ser 
            820                 825                 830         


Thr Ser His Ser Leu Thr Arg Leu Tyr Val Gly Glu Asn Ala Leu Gly 
        835                 840                 845             


Asp Ser Gly Val Ala Ile Leu Cys Glu Lys Ala Lys Asn Pro Gln Cys 
    850                 855                 860                 


Asn Leu Gln Lys Leu Gly Leu Val Asn Ser Gly Leu Thr Ser Val Cys 
865                 870                 875                 880 


Cys Ser Ala Leu Ser Ser Val Leu Ser Thr Asn Gln Asn Leu Thr His 
                885                 890                 895     


Leu Tyr Leu Arg Gly Asn Thr Leu Gly Asp Lys Gly Ile Lys Leu Leu 
            900                 905                 910         


Cys Glu Gly Leu Leu His Pro Asp Cys Lys Leu Gln Val Leu Glu Leu 
        915                 920                 925             


Asp Asn Cys Asn Leu Thr Ser His Cys Cys Trp Asp Leu Ser Thr Leu 
    930                 935                 940                 


Leu Thr Ser Ser Gln Ser Leu Arg Lys Leu Ser Leu Gly Asn Asn Asp 
945                 950                 955                 960 


Leu Gly Asp Leu Gly Val Met Met Phe Cys Glu Val Leu Lys Gln Gln 
                965                 970                 975     


Ser Cys Leu Leu Gln Asn Leu Gly Leu Ser Glu Met Tyr Phe Asn Tyr 
            980                 985                 990         


Glu Thr Lys Ser Ala Leu Glu Thr  Leu Gln Glu Glu Lys  Pro Glu Leu 
        995                 1000                 1005             


Thr Val  Val Phe Glu Pro Ser  Trp 
    1010                 1015     


