                         SEQUENCE LISTING

<110>  advanceCOR GmbH
 
<120>  Pharmaceutical Composition

<130>  PCT1-17965

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Pro Ser Pro Thr Ala Leu Phe Cys Leu Gly Leu Cys Leu Gly 
1               5                   10                  15      


Arg Val Pro Ala Gln Ser Gly Pro Leu Pro Lys Pro Ser Leu Gln Ala 
            20                  25                  30          


Leu Pro Ser Ser Leu Val Pro Leu Glu Lys Pro Val Thr Leu Arg Cys 
        35                  40                  45              


Gln Gly Pro Pro Gly Val Asp Leu Tyr Arg Leu Glu Lys Leu Ser Ser 
    50                  55                  60                  


Ser Arg Tyr Gln Asp Gln Ala Val Leu Phe Ile Pro Ala Met Lys Arg 
65                  70                  75                  80  


Ser Leu Ala Gly Arg Tyr Arg Cys Ser Tyr Gln Asn Gly Ser Leu Trp 
                85                  90                  95      


Ser Leu Pro Ser Asp Gln Leu Glu Leu Val Ala Thr Gly Val Phe Ala 
            100                 105                 110         


Lys Pro Ser Leu Ser Ala Gln Pro Gly Pro Ala Val Ser Ser Gly Gly 
        115                 120                 125             


Asp Val Thr Leu Gln Cys Gln Thr Arg Tyr Gly Phe Asp Gln Phe Ala 
    130                 135                 140                 


Leu Tyr Lys Glu Gly Asp Pro Ala Pro Tyr Lys Asn Pro Glu Arg Trp 
145                 150                 155                 160 


Tyr Arg Ala Ser Phe Pro Ile Ile Thr Val Thr Ala Ala His Ser Gly 
                165                 170                 175     


Thr Tyr Arg Cys Tyr Ser Phe Ser Ser Arg Asp Pro Tyr Leu Trp Ser 
            180                 185                 190         


Ala Pro Ser Asp Pro Leu Glu Leu Val Val Thr Gly Thr Ser Val Thr 
        195                 200                 205             


Pro Ser Arg Leu Pro Thr Glu Pro Pro Ser Ser Val Ala Glu Phe Ser 
    210                 215                 220                 


Glu Ala Thr Ala Glu Leu Thr Val Ser Phe Thr Asn Lys Val Phe Thr 
225                 230                 235                 240 


Thr Glu Thr Ser Arg Ser Ile Thr Thr Ser Pro Lys Glu Ser Asp Ser 
                245                 250                 255     


Pro Ala Gly Pro Ala Arg Gln Tyr Tyr Thr Lys Gly Asn Gly Gly Arg 
            260                 265                 270         


Glu Ser Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        275                 280                 285             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    290                 295                 300                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
305                 310                 315                 320 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                325                 330                 335     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            340                 345                 350         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        355                 360                 365             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    370                 375                 380                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
385                 390                 395                 400 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                405                 410                 415     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            420                 425                 430         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        435                 440                 445             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    450                 455                 460                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
465                 470                 475                 480 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                485                 490                 495     


Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 


<210>  2
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide / Extracellular Domain / Transmembrane and 
       cytoplasmic domains

Cynomolgus monkey GPVI

<400>  2

Met Ser Pro Ser Pro Thr Thr Leu Phe Cys Leu Gly Leu Cys Leu Gly 
1               5                   10                  15      


His Val Pro Ala Gln Arg Gly Pro Leu Pro Lys Pro Ser Leu Gln Ala 
            20                  25                  30          


Leu Pro Ser Ser Leu Val Pro Leu Glu Lys Pro Val Thr Leu Arg Cys 
        35                  40                  45              


Gln Gly Pro Pro Gly Val Asp Leu Tyr Arg Leu Glu Lys Leu Ser Ser 
    50                  55                  60                  


Ser Arg Tyr Gln Asp Gln Ala Val Leu Phe Ile Pro Ala Met Lys Arg 
65                  70                  75                  80  


His Leu Ala Gly Arg Tyr Arg Cys Ser Tyr Gln Asn Gly Ser Leu Trp 
                85                  90                  95      


Ser Pro Pro Ser Asp Gln Leu Glu Leu Val Ala Thr Gly Val Phe Ala 
            100                 105                 110         


Lys Pro Ser Leu Ser Ala Gln Pro Gly Pro Ala Val Ser Ser Gly Gly 
        115                 120                 125             


Asp Val Thr Leu Gln Cys Gln Thr Arg Tyr Gly Phe Asp Gln Phe Ala 
    130                 135                 140                 


Leu Tyr Lys Glu Gly Asp Pro Ala Pro Tyr Lys Asn Pro Glu Arg Trp 
145                 150                 155                 160 


Tyr Arg Ala Ser Phe Pro Ile Ile Thr Val Thr Ala Ala His Ser Gly 
                165                 170                 175     


Thr Tyr Arg Cys Tyr Ser Phe Ser Ser Gly Asp Pro Tyr Leu Trp Ser 
            180                 185                 190         


Ala Pro Ser Asp Pro Leu Glu Leu Met Val Thr Glu Phe Ser Glu Ala 
        195                 200                 205             


Thr Thr Glu Leu Thr Val Ser Leu Thr Asn Lys Val Phe Thr Thr Glu 
    210                 215                 220                 


Thr Ser Arg Ser Ile Thr Ala Ser Pro Lys Glu Pro Gly Ser Pro Ala 
225                 230                 235                 240 


Gly Pro Ala Arg Gln Tyr Tyr Thr Lys Gly Asn Leu Val Arg Ile Cys 
                245                 250                 255     


Leu Gly Ala Val Ile Leu Ile Leu Leu Ala Gly Phe Leu Ala Glu Asp 
            260                 265                 270         


Trp His Ser Arg Arg Lys Arg Leu Arg His Arg Val Arg Ala Val Gln 
        275                 280                 285             


Arg Pro Leu Pro Pro Leu Pro Pro Thr Arg Lys Ser His Gly Asp Gln 
    290                 295                 300                 


Asp Gly Gly Arg Pro Asp Val His Ser Arg Gly Leu Cys Ser 
305                 310                 315             


<210>  3
<211>  313
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ser Pro Ala Ser Pro Thr Phe Phe Cys Ile Gly Leu Cys Val Leu 
1               5                   10                  15      


Gln Val Ile Gln Thr Gln Ser Gly Pro Leu Pro Lys Pro Ser Leu Gln 
            20                  25                  30          


Ala Gln Pro Ser Ser Leu Val Pro Leu Gly Gln Ser Val Ile Leu Arg 
        35                  40                  45              


Cys Gln Gly Pro Pro Asp Val Asp Leu Tyr Arg Leu Glu Lys Leu Lys 
    50                  55                  60                  


Pro Glu Lys Tyr Glu Asp Gln Asp Phe Leu Phe Ile Pro Thr Met Glu 
65                  70                  75                  80  


Arg Ser Asn Ala Gly Arg Tyr Arg Cys Ser Tyr Gln Asn Gly Ser His 
                85                  90                  95      


Trp Ser Leu Pro Ser Asp Gln Leu Glu Leu Ile Ala Thr Gly Val Tyr 
            100                 105                 110         


Ala Lys Pro Ser Leu Ser Ala His Pro Ser Ser Ala Val Pro Gln Gly 
        115                 120                 125             


Arg Asp Val Thr Leu Lys Cys Gln Ser Pro Tyr Ser Phe Asp Glu Phe 
    130                 135                 140                 


Val Leu Tyr Lys Glu Gly Asp Thr Gly Ser Tyr Lys Arg Pro Glu Lys 
145                 150                 155                 160 


Trp Tyr Arg Ala Asn Phe Pro Ile Ile Thr Val Thr Ala Ala His Ser 
                165                 170                 175     


Gly Thr Tyr Arg Cys Tyr Ser Phe Ser Ser Ser Ser Pro Tyr Leu Trp 
            180                 185                 190         


Ser Ala Pro Ser Asp Pro Leu Val Leu Val Val Thr Gly Leu Ser Ala 
        195                 200                 205             


Thr Pro Ser Gln Val Pro Thr Glu Glu Ser Phe Pro Val Thr Glu Ser 
    210                 215                 220                 


Ser Arg Arg Pro Ser Ile Leu Pro Thr Asn Lys Ile Ser Thr Thr Glu 
225                 230                 235                 240 


Lys Pro Met Asn Ile Thr Ala Ser Pro Glu Gly Leu Ser Pro Pro Phe 
                245                 250                 255     


Gly Phe Ala His Gln His Tyr Ala Lys Gly Asn Leu Val Arg Ile Cys 
            260                 265                 270         


Leu Gly Ala Thr Ile Ile Ile Ile Leu Leu Gly Leu Leu Ala Glu Asp 
        275                 280                 285             


Trp His Ser Arg Lys Lys Cys Leu Gln His Arg Met Arg Ala Leu Gln 
    290                 295                 300                 


Arg Pro Leu Pro Pro Leu Pro Leu Ala 
305                 310             


<210>  4
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  extracellular domain of human GPVI-1A

<400>  4

Gln Ser Gly Pro Leu Pro Lys Pro Ser Leu Gln Ala Leu Pro Ser Ser 
1               5                   10                  15      


Leu Val Pro Leu Glu Lys Pro Val Thr Leu Arg Cys Gln Gly Pro Pro 
            20                  25                  30          


Gly Val Asp Leu Tyr Arg Leu Glu Lys Leu Ser Ser Ser Arg Tyr Gln 
        35                  40                  45              


Asp Gln Ala Val Leu Phe Ile Pro Ala Met Lys Arg Ser Leu Ala Gly 
    50                  55                  60                  


Arg Tyr Arg Cys Ser Tyr Gln Asn Gly Ser Leu Trp Ser Leu Pro Ser 
65                  70                  75                  80  


Asp Gln Leu Glu Leu Val Ala Thr Gly Val Phe Ala Lys Pro Ser Leu 
                85                  90                  95      


Ser Ala Gln Pro Gly Pro Ala Val Ser Ser Gly Gly Asp Val Thr Leu 
            100                 105                 110         


Gln Cys Gln Thr Arg Tyr Gly Phe Asp Gln Phe Ala Leu Tyr Lys Glu 
        115                 120                 125             


Gly Asp Pro Ala Pro Tyr Lys Asn Pro Glu Arg Trp Tyr Arg Ala Ser 
    130                 135                 140                 


Phe Pro Ile Ile Thr Val Thr Ala Ala His Ser Gly Thr Tyr Arg Cys 
145                 150                 155                 160 


Tyr Ser Phe Ser Ser Arg Asp Pro Tyr Leu Trp Ser Ala Pro Ser Asp 
                165                 170                 175     


Pro Leu Glu Leu Val Val Thr Gly Thr Ser Val Thr Pro Ser Arg Leu 
            180                 185                 190         


Pro Thr Glu Pro Pro Ser Ser Val Ala Glu Phe Ser Glu Ala Thr Ala 
        195                 200                 205             


Glu Leu Thr Val Ser Phe Thr Asn Lys Val Phe Thr Thr Glu Thr Ser 
    210                 215                 220                 


Arg Ser Ile Thr Thr Ser Pro Lys Glu Ser Asp Ser Pro Ala Gly Pro 
225                 230                 235                 240 


Ala Arg Gln Tyr Tyr Thr Lys Gly Asn 
                245                 


<210>  5
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  extracellular domain of human GPVI-1B

<400>  5

Gln Ser Gly Pro Leu Pro Lys Pro Ser Leu Gln Ala Leu Pro Ser Ser 
1               5                   10                  15      


Leu Val Pro Leu Glu Lys Pro Val Thr Leu Arg Cys Gln Gly Pro Pro 
            20                  25                  30          


Gly Val Asp Leu Tyr Arg Leu Glu Lys Leu Ser Ser Ser Arg Tyr Gln 
        35                  40                  45              


Asp Gln Ala Val Leu Phe Ile Pro Ala Met Lys Arg Ser Leu Ala Gly 
    50                  55                  60                  


Arg Tyr Arg Cys Ser Tyr Gln Asn Gly Ser Leu Trp Ser Leu Pro Ser 
65                  70                  75                  80  


Asp Gln Leu Glu Leu Val Ala Thr Gly Val Phe Ala Lys Pro Ser Leu 
                85                  90                  95      


Ser Ala Gln Pro Gly Pro Ala Val Ser Ser Gly Gly Asp Val Thr Leu 
            100                 105                 110         


Gln Cys Gln Thr Arg Tyr Gly Phe Asp Gln Phe Ala Leu Tyr Lys Glu 
        115                 120                 125             


Gly Asp Pro Ala Pro Tyr Lys Asn Pro Glu Arg Trp Tyr Arg Ala Ser 
    130                 135                 140                 


Phe Pro Ile Ile Thr Val Thr Ala Ala His Ser Gly Thr Tyr Arg Cys 
145                 150                 155                 160 


Tyr Ser Phe Ser Ser Arg Asp Pro Tyr Leu Trp Ser Ala Pro Ser Asp 
                165                 170                 175     


Pro Leu Glu Leu Val Val Thr Gly Thr Ser Val Thr Pro Ser Arg Leu 
            180                 185                 190         


Pro Thr Glu Pro Pro Ser Pro Val Ala Glu Phe Ser Glu Ala Thr Ala 
        195                 200                 205             


Glu Leu Thr Val Ser Phe Thr Asn Glu Val Phe Thr Thr Glu Thr Ser 
    210                 215                 220                 


Arg Ser Ile Thr Ala Ser Pro Lys Glu Ser Asp Ser Pro Ala Gly Pro 
225                 230                 235                 240 


Ala Arg Gln Tyr Tyr Thr Lys Gly Asn 
                245                 


<210>  6
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  extracellular domain of human GPVI-2A

<400>  6

Gln Ser Gly Pro Leu Pro Lys Pro Ser Leu Gln Ala Leu Pro Ser Ser 
1               5                   10                  15      


Leu Val Pro Leu Glu Lys Pro Val Thr Leu Arg Cys Gln Gly Pro Pro 
            20                  25                  30          


Gly Val Asp Leu Tyr Arg Leu Glu Lys Leu Ser Ser Ser Arg Tyr Gln 
        35                  40                  45              


Asp Gln Ala Val Leu Phe Ile Pro Ala Met Lys Arg Ser Leu Ala Gly 
    50                  55                  60                  


Arg Tyr Arg Cys Ser Tyr Gln Asn Gly Ser Leu Trp Ser Leu Pro Ser 
65                  70                  75                  80  


Asp Gln Leu Glu Leu Val Ala Thr Gly Val Phe Ala Lys Pro Ser Leu 
                85                  90                  95      


Ser Ala Gln Pro Gly Pro Ala Val Ser Ser Gly Gly Asp Val Thr Leu 
            100                 105                 110         


Gln Cys Gln Thr Arg Tyr Gly Phe Asp Gln Phe Ala Leu Tyr Lys Glu 
        115                 120                 125             


Gly Asp Pro Ala Pro Tyr Lys Asn Pro Glu Arg Trp Tyr Arg Ala Ser 
    130                 135                 140                 


Phe Pro Ile Ile Thr Val Thr Ala Ala His Ser Gly Thr Tyr Arg Cys 
145                 150                 155                 160 


Tyr Ser Phe Ser Ser Arg Asp Pro Tyr Leu Trp Ser Ala Pro Ser Asp 
                165                 170                 175     


Pro Leu Glu Leu Val Val Thr Glu Phe Ser Glu Ala Thr Ala Glu Leu 
            180                 185                 190         


Thr Val Ser Phe Thr Asn Lys Val Phe Thr Thr Glu Thr Ser Arg Ser 
        195                 200                 205             


Ile Thr Thr Ser Pro Lys Glu Ser Asp Ser Pro Ala Gly Pro Ala Arg 
    210                 215                 220                 


Gln Tyr Tyr Thr Lys Gly Asn 
225                 230     


<210>  7
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  extracellular domain of cynomolgus monkey GPVI

<400>  7

Gln Arg Gly Pro Leu Pro Lys Pro Ser Leu Gln Ala Leu Pro Ser Ser 
1               5                   10                  15      


Leu Val Pro Leu Glu Lys Pro Val Thr Leu Arg Cys Gln Gly Pro Pro 
            20                  25                  30          


Gly Val Asp Leu Tyr Arg Leu Glu Lys Leu Ser Ser Ser Arg Tyr Gln 
        35                  40                  45              


Asp Gln Ala Val Leu Phe Ile Pro Ala Met Lys Arg His Leu Ala Gly 
    50                  55                  60                  


Arg Tyr Arg Cys Ser Tyr Gln Asn Gly Ser Leu Trp Ser Pro Pro Ser 
65                  70                  75                  80  


Asp Gln Leu Glu Leu Val Ala Thr Gly Val Phe Ala Lys Pro Ser Leu 
                85                  90                  95      


Ser Ala Gln Pro Gly Pro Ala Val Ser Ser Gly Gly Asp Val Thr Leu 
            100                 105                 110         


Gln Cys Gln Thr Arg Tyr Gly Phe Asp Gln Phe Ala Leu Tyr Lys Glu 
        115                 120                 125             


Gly Asp Pro Ala Pro Tyr Lys Asn Pro Glu Arg Trp Tyr Arg Ala Ser 
    130                 135                 140                 


Phe Pro Ile Ile Thr Val Thr Ala Ala His Ser Gly Thr Tyr Arg Cys 
145                 150                 155                 160 


Tyr Ser Phe Ser Ser Gly Asp Pro Tyr Leu Trp Ser Ala Pro Ser Asp 
                165                 170                 175     


Pro Leu Glu Leu Met Val Thr Glu Phe Ser Glu Ala Thr Thr Glu Leu 
            180                 185                 190         


Thr Val Ser Leu Thr Asn Lys Val Phe Thr Thr Glu Thr Ser Arg Ser 
        195                 200                 205             


Ile Thr Ala Ser Pro Lys Glu Pro Gly Ser Pro Ala Gly Pro Ala Arg 
    210                 215                 220                 


Gln Tyr Tyr Thr Lys 
225                 


<210>  8
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  extracellular domain of mouse GPVI

<400>  8

Gln Ser Gly Pro Leu Pro Lys Pro Ser Leu Gln Ala Gln Pro Ser Ser 
1               5                   10                  15      


Leu Val Pro Leu Gly Gln Ser Val Ile Leu Arg Cys Gln Gly Pro Pro 
            20                  25                  30          


Asp Val Asp Leu Tyr Arg Leu Glu Lys Leu Lys Pro Glu Lys Tyr Glu 
        35                  40                  45              


Asp Gln Asp Phe Leu Phe Ile Pro Thr Met Glu Arg Ser Asn Ala Gly 
    50                  55                  60                  


Arg Tyr Arg Cys Ser Tyr Gln Asn Gly Ser His Trp Ser Leu Pro Ser 
65                  70                  75                  80  


Asp Gln Leu Glu Leu Ile Ala Thr Gly Val Tyr Ala Lys Pro Ser Leu 
                85                  90                  95      


Ser Ala His Pro Ser Ser Ala Val Pro Gln Gly Arg Asp Val Thr Leu 
            100                 105                 110         


Lys Cys Gln Ser Pro Tyr Ser Phe Asp Glu Phe Val Leu Tyr Lys Glu 
        115                 120                 125             


Gly Asp Thr Gly Ser Tyr Lys Arg Pro Glu Lys Trp Tyr Arg Ala Asn 
    130                 135                 140                 


Phe Pro Ile Ile Thr Val Thr Ala Ala His Ser Gly Thr Tyr Arg Cys 
145                 150                 155                 160 


Tyr Ser Phe Ser Ser Ser Ser Pro Tyr Leu Trp Ser Ala Pro Ser Asp 
                165                 170                 175     


Pro Leu Val Leu Val Val Thr Gly Leu Ser Ala Thr Pro Ser Gln Val 
            180                 185                 190         


Pro Thr Glu Glu Ser Phe Pro Val Thr Glu Ser Ser Arg Arg Pro Ser 
        195                 200                 205             


Ile Leu Pro Thr Asn Lys Ile Ser Thr Thr Glu Lys Pro Met Asn Ile 
    210                 215                 220                 


Thr Ala Ser Pro Glu Gly Leu Ser Pro Pro Phe Gly Phe Ala His Gln 
225                 230                 235                 240 


His Tyr Ala Lys Gly Asn 
                245     


<210>  9
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  extracellular domain of rat GPVI

<400>  9

Gln His Gly Pro Leu Pro Lys Pro Ser Leu Gln Ala Gln Pro Ser Ser 
1               5                   10                  15      


Leu Val Pro Leu Gly His Pro Val Thr Leu Arg Cys Leu Gly Pro Ser 
            20                  25                  30          


Asp Ala Asp Leu Tyr Arg Leu Glu Lys Val Lys Pro Gly Lys Leu Ile 
        35                  40                  45              


Phe Ile Asp Gln Asp Phe Leu Phe Ile Pro Ile Met Glu Ile Asn Asn 
    50                  55                  60                  


Ala Gly Arg Tyr Arg Cys Ser Tyr Gln Asn Glu Ser His Trp Ser Leu 
65                  70                  75                  80  


Pro Ser Asp Gln Leu Glu Leu Ile Ala Thr Gly Val Tyr Ser Lys Pro 
                85                  90                  95      


Ser Leu Ser Ala His Pro Ser Ser Ala Ile Pro Pro Gly Arg Asp Val 
            100                 105                 110         


Thr Leu Lys Cys Gln Ser Gln Tyr Ser Phe Asp Glu Phe Val Leu Tyr 
        115                 120                 125             


Lys Glu Gly Asp Thr Arg Pro Tyr Lys Arg Pro Glu Lys Trp Tyr Arg 
    130                 135                 140                 


Ala Asn Phe Pro Val Ile Thr Val Thr Ala Ala His Ser Gly Thr Tyr 
145                 150                 155                 160 


Arg Cys Tyr Ser Phe Ser Ser Ser Ser Pro Tyr Leu Trp Ser Ala Pro 
                165                 170                 175     


Ser Asp Pro Leu Val Val Val Val Thr Gly Pro Ser Ala Thr Pro Ser 
            180                 185                 190         


Gln Val Pro Thr Glu Val Pro Ser Pro Met Thr Glu Ala Ser Arg Arg 
        195                 200                 205             


Pro Ser Met Leu Leu Thr Asn Lys Ile Ser Thr Thr Glu Lys Pro Met 
    210                 215                 220                 


Asn Ile Thr Val Ser Pro Glu Gly Pro Ser Pro Pro Phe Gly Phe Ala 
225                 230                 235                 240 


His Gln His Tyr Ala Lys Gly Asn 
                245             


<210>  10
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  10

Asp Ile Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
1               5                   10                  15      


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys 
225             


<210>  11
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Pro Ser Pro Thr Ala Leu Phe Cys Leu Gly Leu Cys Leu Gly 
1               5                   10                  15      


Arg Val Pro Ala Gln Ser Gly Pro Leu Pro Lys Pro Ser Leu Gln Ala 
            20                  25                  30          


Leu Pro Ser Ser Leu Val Pro Leu Glu Lys Pro Val Thr Leu Arg Cys 
        35                  40                  45              


Gln Gly Pro Pro Gly Val Asp Leu Tyr Arg Leu Glu Lys Leu Ser Ser 
    50                  55                  60                  


Ser Arg Tyr Gln Asp Gln Ala Val Leu Phe Ile Pro Ala Met Lys Arg 
65                  70                  75                  80  


Ser Leu Ala Gly Arg Tyr Arg Cys Ser Tyr Gln Asn Gly Ser Leu Trp 
                85                  90                  95      


Ser Leu Pro Ser Asp Gln Leu Glu Leu Val Ala Thr Gly Val Phe Ala 
            100                 105                 110         


Lys Pro Ser Leu Ser Ala Gln Pro Gly Pro Ala Val Ser Ser Gly Gly 
        115                 120                 125             


Asp Val Thr Leu Gln Cys Gln Thr Arg Tyr Gly Phe Asp Gln Phe Ala 
    130                 135                 140                 


Leu Tyr Lys Glu Gly Asp Pro Ala Pro Tyr Lys Asn Pro Glu Arg Trp 
145                 150                 155                 160 


Tyr Arg Ala Ser Phe Pro Ile Ile Thr Val Thr Ala Ala His Ser Gly 
                165                 170                 175     


Thr Tyr Arg Cys Tyr Ser Phe Ser Ser Arg Asp Pro Tyr Leu Trp Ser 
            180                 185                 190         


Ala Pro Ser Asp Pro Leu Glu Leu Val Val Thr Gly Thr Ser Val Thr 
        195                 200                 205             


Pro Ser Arg Leu Pro Thr Glu Pro Pro Ser Ser Val Ala Glu Phe Ser 
    210                 215                 220                 


Glu Ala Thr Ala Glu Leu Thr Val Ser Phe Thr Asn Lys Val Phe Thr 
225                 230                 235                 240 


Thr Glu Thr Ser Arg Ser Ile Thr Thr Ser Pro Lys Glu Ser Asp Ser 
                245                 250                 255     


Pro Ala Gly Pro Ala Arg Gln Tyr Tyr Thr Lys Gly Asn Leu Val Arg 
            260                 265                 270         


Ile Cys Leu Gly Ala Val Ile Leu Ile Ile Leu Ala Gly Phe Leu Ala 
        275                 280                 285             


Glu Asp Trp His Ser Arg Arg Lys Arg Leu Arg His Arg Gly Arg Ala 
    290                 295                 300                 


Val Gln Arg Pro Leu Pro Pro Leu Pro Pro Leu Pro Leu Thr Arg Lys 
305                 310                 315                 320 


Ser Asn Gly Gly Gln Asp Gly Gly Arg Gln Asp Val His Ser Arg Gly 
                325                 330                 335     


Leu Cys Ser 
            


