                         б

<110>  ѩѧ㶫޹˾
 
<120>  һʶAFPԭTCR

<130>  22DX0957FPPC

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  1

Gly Ile Gln Val Glu Gln Ser Pro Pro Asp Leu Ile Leu Gln Glu Gly 
1               5                   10                  15      


Ala Asn Ser Thr Leu Arg Cys Asn Phe Ser Asp Ser Val Asn Asn Leu 
            20                  25                  30          


Gln Trp Phe His Gln Asn Pro Trp Gly Gln Leu Ile Asn Leu Phe Tyr 
        35                  40                  45              


Ile Pro Ser Gly Thr Lys Gln Asn Gly Arg Leu Ser Ala Thr Thr Val 
    50                  55                  60                  


Ala Thr Glu Arg Tyr Ser Leu Leu Tyr Ile Ser Ser Ser Gln Thr Thr 
65                  70                  75                  80  


Asp Ser Gly Val Tyr Phe Cys Ser Gly Gly Ser Asn Tyr Lys Leu Thr 
                85                  90                  95      


Phe Gly Lys Gly Thr Leu Leu Thr Val Asn Pro 
            100                 105         


<210>  2
<211>  321
<212>  DNA
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  2
ggaatacaag tggagcagag tcctccagac ctgattctcc aggagggagc caattccacg       60

ctgcggtgca atttttctga ctctgtgaac aatttgcagt ggtttcatca aaacccttgg      120

ggacagctca tcaacctgtt ttacattccc tcagggacaa aacagaatgg aagattaagc      180

gccacgactg tcgctacgga acgctacagc ttattgtaca tttcctcttc ccagaccaca      240

gactcaggcg tttatttctg cagtggaggt agcaactata aactgacatt tggaaaagga      300

actctcttaa ccgtgaatcc a                                                321


<210>  3
<211>  248
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  3

Gly Ile Gln Val Glu Gln Ser Pro Pro Asp Leu Ile Leu Gln Glu Gly 
1               5                   10                  15      


Ala Asn Ser Thr Leu Arg Cys Asn Phe Ser Asp Ser Val Asn Asn Leu 
            20                  25                  30          


Gln Trp Phe His Gln Asn Pro Trp Gly Gln Leu Ile Asn Leu Phe Tyr 
        35                  40                  45              


Ile Pro Ser Gly Thr Lys Gln Asn Gly Arg Leu Ser Ala Thr Thr Val 
    50                  55                  60                  


Ala Thr Glu Arg Tyr Ser Leu Leu Tyr Ile Ser Ser Ser Gln Thr Thr 
65                  70                  75                  80  


Asp Ser Gly Val Tyr Phe Cys Ser Gly Gly Ser Asn Tyr Lys Leu Thr 
                85                  90                  95      


Phe Gly Lys Gly Thr Leu Leu Thr Val Asn Pro Asn Ile Gln Asn Pro 
            100                 105                 110         


Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser 
        115                 120                 125             


Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser 
    130                 135                 140                 


Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg 
145                 150                 155                 160 


Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser 
                165                 170                 175     


Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp 
            180                 185                 190         


Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu 
        195                 200                 205             


Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val 
    210                 215                 220                 


Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
225                 230                 235                 240 


Met Thr Leu Arg Leu Trp Ser Ser 
                245             


<210>  4
<211>  744
<212>  DNA
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  4
ggaatacaag tggagcagag tcctccagac ctgattctcc aggagggagc caattccacg       60

ctgcggtgca atttttctga ctctgtgaac aatttgcagt ggtttcatca aaacccttgg      120

ggacagctca tcaacctgtt ttacattccc tcagggacaa aacagaatgg aagattaagc      180

gccacgactg tcgctacgga acgctacagc ttattgtaca tttcctcttc ccagaccaca      240

gactcaggcg tttatttctg cagtggaggt agcaactata aactgacatt tggaaaagga      300

actctcttaa ccgtgaatcc aaatatccag aaccctgacc ctgccgtgta ccagctgaga      360

gactctaaat ccagtgacaa gtctgtctgc ctattcaccg attttgattc tcaaacaaat      420

gtgtcacaaa gtaaggattc tgatgtgtat atcacagaca aaactgtgct agacatgagg      480

tctatggact tcaagagcaa cagtgctgtg gcctggagca acaaatctga ctttgcatgt      540

gcaaacgcct tcaacaacag cattattcca gaagacacct tcttccccag cccagaaagt      600

tcctgtgatg tcaagctggt cgagaaaagc tttgaaacag atacgaacct aaactttcaa      660

aacctgtcag tgattgggtt ccgaatcctc ctcctgaaag tggccgggtt taatctgctc      720

atgacgctgc ggctgtggtc cagc                                             744


<210>  5
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  5

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Val Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val 
    


<210>  6
<211>  339
<212>  DNA
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  6
gatactggag tctcccagga ccccagacac aagatcacaa agaggggaca gaatgtaact       60

ttcaggtgtg atccaatttc tgaacacaac cgcctttatt ggtaccgaca gaccctgggg      120

cagggcccag agtttctgac ttacttccag aatgaagctc aactagaaaa atcaaggctg      180

ctcagtgatc ggttctctgc agagaggcct aagggatctt tctccacctt ggagatccag      240

cgcacagagc agggggactc ggccatgtat ctctgtgcca gcagccccgg gacaggggtt      300

ggctacacct tcggttcggg gaccaggtta accgttgta                             339


<210>  7
<211>  290
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  7

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Val Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu 
        115                 120                 125             


Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys 
    130                 135                 140                 


Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
145                 150                 155                 160 


Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu 
                165                 170                 175     


Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg 
            180                 185                 190         


Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg 
        195                 200                 205             


Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln 
    210                 215                 220                 


Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly 
225                 230                 235                 240 


Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu 
                245                 250                 255     


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
            260                 265                 270         


Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys 
        275                 280                 285             


Asp Phe 
    290 


<210>  8
<211>  870
<212>  DNA
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  8
gatactggag tctcccagga ccccagacac aagatcacaa agaggggaca gaatgtaact       60

ttcaggtgtg atccaatttc tgaacacaac cgcctttatt ggtaccgaca gaccctgggg      120

cagggcccag agtttctgac ttacttccag aatgaagctc aactagaaaa atcaaggctg      180

ctcagtgatc ggttctctgc agagaggcct aagggatctt tctccacctt ggagatccag      240

cgcacagagc agggggactc ggccatgtat ctctgtgcca gcagccccgg gacaggggtt      300

ggctacacct tcggttcggg gaccaggtta accgttgtag aggacctgaa caaggtgttc      360

ccacccgagg tcgctgtgtt tgagccatca gaagcagaga tctcccacac ccaaaaggcc      420

acactggtgt gcctggccac aggcttcttc cccgaccacg tggagctgag ctggtgggtg      480

aatgggaagg aggtgcacag tggggtcagc acggacccgc agcccctcaa ggagcagccc      540

gccctcaatg actccagata ctgcctgagc agccgcctga gggtctcggc caccttctgg      600

cagaaccccc gcaaccactt ccgctgtcaa gtccagttct acgggctctc ggagaatgac      660

gagtggaccc aggatagggc caaacccgtc acccagatcg tcagcgccga ggcctggggt      720

agagcagact gtggctttac ctcggtgtcc taccagcaag gggtcctgtc tgccaccatc      780

ctctatgaga tcctgctagg gaaggccacc ctgtatgctg tgctggtcag cgcccttgtg      840

ttgatggcca tggtcaagag aaaggatttc                                       870


<210>  9
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  9

Thr Ser Ser Glu Leu Met Ala Ile Thr Arg 
1               5                   10  


<210>  10
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  10

Asp Ser Val Asn Asn 
1               5   


<210>  11
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  11

Ile Pro Ser Gly Thr 
1               5   


<210>  12
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  12

Ser Gly Gly Ser Asn Tyr Lys Leu Thr 
1               5                   


<210>  13
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  13

Ser Glu His Asn Arg 
1               5   


<210>  14
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  14

Phe Gln Asn Glu Ala Gln 
1               5       


<210>  15
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  15

Ala Ser Ser Pro Gly Thr Gly Val Gly Tyr Thr 
1               5                   10      


<210>  16
<211>  15
<212>  DNA
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  16
gactctgtga acaat                                                        15


<210>  17
<211>  15
<212>  DNA
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  17
attccctcag ggaca                                                        15


<210>  18
<211>  27
<212>  DNA
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  18
agtggaggta gcaactataa actgaca                                           27


<210>  19
<211>  15
<212>  DNA
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  19
tctgaacaca accgc                                                        15


<210>  20
<211>  18
<212>  DNA
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  20
ttccagaatg aagctcaa                                                     18


<210>  21
<211>  33
<212>  DNA
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  21
gccagcagcc ccgggacagg ggttggctac acc                                    33


<210>  22
<211>  268
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  22

Met Lys Arg Ile Leu Gly Ala Leu Leu Gly Leu Leu Ser Ala Gln Val 
1               5                   10                  15      


Cys Cys Val Arg Gly Ile Gln Val Glu Gln Ser Pro Pro Asp Leu Ile 
            20                  25                  30          


Leu Gln Glu Gly Ala Asn Ser Thr Leu Arg Cys Asn Phe Ser Asp Ser 
        35                  40                  45              


Val Asn Asn Leu Gln Trp Phe His Gln Asn Pro Trp Gly Gln Leu Ile 
    50                  55                  60                  


Asn Leu Phe Tyr Ile Pro Ser Gly Thr Lys Gln Asn Gly Arg Leu Ser 
65                  70                  75                  80  


Ala Thr Thr Val Ala Thr Glu Arg Tyr Ser Leu Leu Tyr Ile Ser Ser 
                85                  90                  95      


Ser Gln Thr Thr Asp Ser Gly Val Tyr Phe Cys Ser Gly Gly Ser Asn 
            100                 105                 110         


Tyr Lys Leu Thr Phe Gly Lys Gly Thr Leu Leu Thr Val Asn Pro Asn 
        115                 120                 125             


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
    130                 135                 140                 


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
145                 150                 155                 160 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
                165                 170                 175     


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
            180                 185                 190         


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
        195                 200                 205             


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val 
    210                 215                 220                 


Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  23
<211>  804
<212>  DNA
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  23
atgaagagga tattgggagc tctgctgggg ctcttgagtg cccaggtttg ctgtgtgaga       60

ggaatacaag tggagcagag tcctccagac ctgattctcc aggagggagc caattccacg      120

ctgcggtgca atttttctga ctctgtgaac aatttgcagt ggtttcatca aaacccttgg      180

ggacagctca tcaacctgtt ttacattccc tcagggacaa aacagaatgg aagattaagc      240

gccacgactg tcgctacgga acgctacagc ttattgtaca tttcctcttc ccagaccaca      300

gactcaggcg tttatttctg cagtggaggt agcaactata aactgacatt tggaaaagga      360

actctcttaa ccgtgaatcc aaatatccag aaccctgacc ctgccgtgta ccagctgaga      420

gactctaaat ccagtgacaa gtctgtctgc ctattcaccg attttgattc tcaaacaaat      480

gtgtcacaaa gtaaggattc tgatgtgtat atcacagaca aaactgtgct agacatgagg      540

tctatggact tcaagagcaa cagtgctgtg gcctggagca acaaatctga ctttgcatgt      600

gcaaacgcct tcaacaacag cattattcca gaagacacct tcttccccag cccagaaagt      660

tcctgtgatg tcaagctggt cgagaaaagc tttgaaacag atacgaacct aaactttcaa      720

aacctgtcag tgattgggtt ccgaatcctc ctcctgaaag tggccgggtt taatctgctc      780

atgacgctgc ggctgtggtc cagc                                             804


<210>  24
<211>  309
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  24

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Thr Gly Val Gly Tyr Thr Phe Gly Ser Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Phe 
305                 


<210>  25
<211>  927
<212>  DNA
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  25
atgggcacca gcctcctctg ctggatggcc ctgtgtctcc tgggggcaga tcacgcagat       60

actggagtct cccaggaccc cagacacaag atcacaaaga ggggacagaa tgtaactttc      120

aggtgtgatc caatttctga acacaaccgc ctttattggt accgacagac cctggggcag      180

ggcccagagt ttctgactta cttccagaat gaagctcaac tagaaaaatc aaggctgctc      240

agtgatcggt tctctgcaga gaggcctaag ggatctttct ccaccttgga gatccagcgc      300

acagagcagg gggactcggc catgtatctc tgtgccagca gccccgggac aggggttggc      360

tacaccttcg gttcggggac caggttaacc gttgtagagg acctgaacaa ggtgttccca      420

cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca      480

ctggtgtgcc tggccacagg cttcttcccc gaccacgtgg agctgagctg gtgggtgaat      540

gggaaggagg tgcacagtgg ggtcagcacg gacccgcagc ccctcaagga gcagcccgcc      600

ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag      660

aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag      720

tggacccagg atagggccaa acccgtcacc cagatcgtca gcgccgaggc ctggggtaga      780

gcagactgtg gctttacctc ggtgtcctac cagcaagggg tcctgtctgc caccatcctc      840

tatgagatcc tgctagggaa ggccaccctg tatgctgtgc tggtcagcgc ccttgtgttg      900

atggccatgg tcaagagaaa ggatttc                                          927


<210>  26
<211>  202
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  26

Met Gly Ile Gln Val Glu Gln Ser Pro Pro Asp Leu Ile Leu Gln Glu 
1               5                   10                  15      


Gly Ala Asn Ser Thr Leu Arg Cys Asn Phe Ser Asp Ser Val Asn Asn 
            20                  25                  30          


Leu Gln Trp Phe His Gln Asn Pro Trp Gly Gln Leu Ile Asn Leu Phe 
        35                  40                  45              


Tyr Ile Pro Ser Gly Thr Lys Gln Asn Gly Arg Leu Ser Ala Thr Thr 
    50                  55                  60                  


Val Ala Thr Glu Arg Tyr Ser Leu Leu Tyr Ile Ser Ser Ser Gln Thr 
65                  70                  75                  80  


Thr Asp Ser Gly Val Tyr Phe Cys Ser Gly Gly Ser Asn Tyr Lys Leu 
                85                  90                  95      


Thr Phe Gly Lys Gly Thr Leu Leu Thr Val Asn Pro Asn Ile Gln Asn 
            100                 105                 110         


Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys 
        115                 120                 125             


Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln 
    130                 135                 140                 


Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met 
145                 150                 155                 160 


Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys 
                165                 170                 175     


Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu 
            180                 185                 190         


Asp Thr Phe Phe Cys Ser Pro Glu Ser Ser 
        195                 200         


<210>  27
<211>  606
<212>  DNA
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  27
atgggcattc aggtggaaca gagtcctcca gacctgattc tccaggaggg agccaattcc       60

acgctgcggt gcaatttttc tgactctgtg aacaatttgc agtggtttca tcaaaaccct      120

tggggacagc tcatcaacct gttttacatt ccctcaggga caaaacagaa tggaagatta      180

agcgccacga ctgtcgctac ggaacgctac agcttattgt acatttcctc ttcccagacc      240

acagactcag gcgtttattt ctgcagtgga ggtagcaact ataaactgac atttggaaaa      300

ggaactctct taaccgtgaa tccaaatatc cagaaccctg accctgccgt ttatcagctg      360

cgtgatagca aaagcagcga taaaagcgtg tgcctgttca ccgattttga tagccagacc      420

aacgtgagcc agagcaaaga tagcgatgtg tacatcaccg ataaaaccgt gctggatatg      480

cgcagcatgg atttcaaaag caatagcgcg gttgcgtgga gcaacaaaag cgattttgcg      540

tgcgcgaacg cgtttaacaa cagcatcatc ccggaagata cgttcttctg cagcccagaa      600

agttcc                                                                 606


<210>  28
<211>  244
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  28

Met Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg 
1               5                   10                  15      


Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg 
            20                  25                  30          


Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr 
        35                  40                  45              


Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp 
    50                  55                  60                  


Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile 
65                  70                  75                  80  


Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser 
                85                  90                  95      


Pro Gly Thr Gly Val Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr 
            100                 105                 110         


Val Val Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe 
        115                 120                 125             


Glu Pro Ser Glu Cys Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val 
    130                 135                 140                 


Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp 
145                 150                 155                 160 


Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro 
                165                 170                 175     


Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala Leu Ser Ser 
            180                 185                 190         


Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe 
        195                 200                 205             


Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr 
    210                 215                 220                 


Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp 
225                 230                 235                 240 


Gly Arg Ala Asp 
                


<210>  29
<211>  732
<212>  DNA
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  29
atggataccg gcgtgagcca ggaccccaga cacaagatca caaagagggg acagaatgta       60

actttcaggt gtgatccaat ttctgaacac aaccgccttt attggtaccg acagaccctg      120

gggcagggcc cagagtttct gacttacttc cagaatgaag ctcaactaga aaaatcaagg      180

ctgctcagtg atcggttctc tgcagagagg cctaagggat ctttctccac cttggagatc      240

cagcgcacag agcaggggga ctcggccatg tatctctgtg ccagcagccc cgggacaggg      300

gttggctaca ccttcggttc ggggaccagg ttaaccgttg tagaggacct gaaaaacgtg      360

ttcccacccg aggtcgctgt gtttgagcca tcagaatgcg aaattagcca tacccagaaa      420

gcgaccctgg tttgtctggc gaccggtttt tatccggatc atgtggaact gtcttggtgg      480

gtgaacggca aagaagtgca tagcggtgtt tctaccgatc cgcagccgct gaaagaacag      540

ccggcgctga atgatagccg ttatgcgctg tctagccgtc tgcgtgttag cgcgaccttt      600

tggcaaaatc cgcgtaacca ttttcgttgc caggtgcagt tttatggcct gagcgaaaac      660

gatgaatgga cccaggatcg tgcgaagccg gttacccaga ttgttagcgc ggaagcctgg      720

ggccgcgcag at                                                          732


<210>  30
<211>  245
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  30

Met Gly Ile Gln Val Glu Gln Ser Pro Pro Asp Leu Asn Val Gln Glu 
1               5                   10                  15      


Gly Glu Asn Val Thr Ile Arg Cys Asn Phe Ser Asp Ser Val Asn Asn 
            20                  25                  30          


Leu Gln Trp Phe His Gln Asn Pro Gly Gly Gln Leu Ile Asn Leu Phe 
        35                  40                  45              


Tyr Ile Pro Ser Gly Thr Lys Gln Asn Gly Arg Leu Ser Ala Thr Thr 
    50                  55                  60                  


Val Ala Thr Glu Arg Tyr Ser Leu Leu Tyr Ile Ser Ser Val Gln Pro 
65                  70                  75                  80  


Thr Asp Ser Gly Val Tyr Phe Cys Ser Gly Gly Ser Asn Tyr Lys Leu 
                85                  90                  95      


Thr Phe Gly Lys Gly Thr Lys Leu Thr Val Asn Pro Gly Gly Gly Ser 
            100                 105                 110         


Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu 
        115                 120                 125             


Gly Gly Thr Gly Asp Thr Gly Val Ser Gln Asp Pro Arg His Leu Ser 
    130                 135                 140                 


Val Lys Arg Gly Gln Asn Val Thr Leu Arg Cys Asp Pro Ile Ser Glu 
145                 150                 155                 160 


His Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Pro Gly Gln Gly Pro Glu 
                165                 170                 175     


Phe Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu 
            180                 185                 190         


Leu Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr 
        195                 200                 205             


Leu Glu Ile Gln Arg Val Glu Pro Gly Asp Ser Ala Met Tyr Phe Cys 
    210                 215                 220                 


Ala Ser Ser Pro Gly Thr Gly Val Gly Tyr Thr Phe Gly Ser Gly Thr 
225                 230                 235                 240 


Arg Leu Thr Val Asp 
                245 


<210>  31
<211>  735
<212>  DNA
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  31
atgggtattc aagttgaaca gagtccgccg gatctgaatg ttcaggaagg cgaaaatgtg       60

accattcgct gcaattttag cgatagcgtg aataatctgc agtggtttca tcagaatccg      120

ggcggtcagc tgattaatct gttttatatt ccgagtggta ccaaacagaa tggccgtctg      180

agcgcaacca ccgttgccac cgaacgctat agtctgctgt atattagcag tgttcagccg      240

accgatagtg gcgtttattt ctgtagcggt ggcagcaatt ataaactgac ctttggtaaa      300

ggtaccaaac tgaccgttaa tccgggcggc ggtagtgaag gtggtggcag cgaaggtggt      360

ggtagtgaag gcggcggttc agaaggtggc accggtgaca ccggcgttag ccaggaccct      420

cgtcatctga gtgtgaaacg tggtcagaat gttaccctgc gttgcgatcc gattagcgaa      480

cataatcgtc tgtattggta tcgtcagacc ccgggccagg gtccggaatt tctgacctat      540

tttcagaatg aagcccagct ggaaaagagt cgtctgctga gtgatcgttt tagtgcagaa      600

cgtccgaaag gcagctttag caccctggaa attcagcgtg ttgaaccagg cgatagtgca      660

atgtatttct gtgcaagctc tcctggcacc ggtgttggct atacctttgg cagtggcact      720

cgtctgaccg ttgat                                                       735


<210>  32
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  32

Gly Ile Gln Val Glu Gln Ser Pro Pro Asp Leu Asn Val Gln Glu Gly 
1               5                   10                  15      


Glu Asn Val Thr Ile Arg Cys Asn Phe Ser Asp Ser Val Asn Asn Leu 
            20                  25                  30          


Gln Trp Phe His Gln Asn Pro Gly Gly Gln Leu Ile Asn Leu Phe Tyr 
        35                  40                  45              


Ile Pro Ser Gly Thr Lys Gln Asn Gly Arg Leu Ser Ala Thr Thr Val 
    50                  55                  60                  


Ala Thr Glu Arg Tyr Ser Leu Leu Tyr Ile Ser Ser Val Gln Pro Thr 
65                  70                  75                  80  


Asp Ser Gly Val Tyr Phe Cys Ser Gly Gly Ser Asn Tyr Lys Leu Thr 
                85                  90                  95      


Phe Gly Lys Gly Thr Lys Leu Thr Val Asn Pro 
            100                 105         


<210>  33
<211>  321
<212>  DNA
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  33
ggtattcaag ttgaacagag tccgccggat ctgaatgttc aggaaggcga aaatgtgacc       60

attcgctgca attttagcga tagcgtgaat aatctgcagt ggtttcatca gaatccgggc      120

ggtcagctga ttaatctgtt ttatattccg agtggtacca aacagaatgg ccgtctgagc      180

gcaaccaccg ttgccaccga acgctatagt ctgctgtata ttagcagtgt tcagccgacc      240

gatagtggcg tttatttctg tagcggtggc agcaattata aactgacctt tggtaaaggt      300

accaaactga ccgttaatcc g                                                321


<210>  34
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  34

Asp Thr Gly Val Ser Gln Asp Pro Arg His Leu Ser Val Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Leu Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Pro Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Val Glu Pro Gly Asp Ser Ala Met Tyr Phe Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Thr Gly Val Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Asp 
    


<210>  35
<211>  339
<212>  DNA
<213>  ˹

<220>
<223>  ϳɵĶ

<400>  35
gacaccggcg ttagccagga ccctcgtcat ctgagtgtga aacgtggtca gaatgttacc       60

ctgcgttgcg atccgattag cgaacataat cgtctgtatt ggtatcgtca gaccccgggc      120

cagggtccgg aatttctgac ctattttcag aatgaagccc agctggaaaa gagtcgtctg      180

ctgagtgatc gttttagtgc agaacgtccg aaaggcagct ttagcaccct ggaaattcag      240

cgtgttgaac caggcgatag tgcaatgtat ttctgtgcaa gctctcctgg caccggtgtt      300

ggctatacct ttggcagtgg cactcgtctg accgttgat                             339


