                         б

<110>  廪ѧ
 
<120>  Ԫ֬ʳ֢ķҩ

<130>  CIE220050PCT

<150>  CN202110674245.2
<151>  2021-06-17

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH

<400>  1
tgcaccacca actgcttagc                                                   20


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH

<400>  2
ggcatggact gtggtcatga g                                                 21


<210>  3
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLN3

<400>  3
ggttgccttt tctcattctg tg                                                22


<210>  4
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLN3

<400>  4
caccaggaga tcacggc                                                      17


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOX2

<400>  5
gtcatttgct gtgggtgatg                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOX2

<400>  6
agaaaaacga gggaaatggg                                                   20


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAX6

<400>  7
ccagaaagga tgcctcataa a                                                 21


<210>  8
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAX6

<400>  8
tctgcgcgcc cctagtta                                                     18


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOGGIN

<400>  9
tcgaacaccc agaccctatc                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOGGIN

<400>  10
catgaagcct gggtcgtagt                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOX1

<400>  11
caatgcgggg aggagaagtc                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOX1

<400>  12
ctctggacca aactgtggcg                                                   20


<210>  13
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OCT4

<400>  13
cagtgcccga aacccacac                                                    19


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OCT4

<400>  14
ggagacccag cagcctcaaa                                                   20


<210>  15
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KEAP1

<400>  15
ctggaggatc ataccaagca gg                                                22


<210>  16
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KEAP1

<400>  16
ggataccctc aatggacacc ac                                                22


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMOX1

<400>  17
aagactgcgt tcctgctcaa c                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HMOX1

<400>  18
aaagccctac agcaactgtc g                                                 21


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NQO1

<400>  19
gaagagcact gatcgtactg gc                                                22


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NQO1

<400>  20
ggatactgaa agttcgcagg g                                                 21


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TXNRD1

<400>  21
taggacaagc cctgcaagac t                                                 21


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TXNRD1

<400>  22
ccccaattca aagagccaat gt                                                22


<210>  23
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTGF

<400>  23
cagcatggac gttcgtctg                                                    19


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTGF

<400>  24
aaccacggtt tggtccttgg                                                   20


<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ATG5

<400>  25
aaagatgtgc ttcgagatgt gt                                                22


<210>  26
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ATG5

<400>  26
cactttgtca gttaccaacg tca                                               23


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p62

<400>  27
tacgacttgt gtagcgtctg                                                   20


<210>  28
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p62

<400>  28
cgtgtttcac cttccggag                                                    19


<210>  29
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mtMinArc

<400>  29
ctaaatagcc cacacgttcc c                                                 21


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mtMinArc

<400>  30
agagctcccg tgagtggtta                                                   20


<210>  31
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  b2M

<400>  31
gctgggtagc tctaaacaat gtattca                                           27


<210>  32
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  b2M

<400>  32
ccatgtacta acaaatgtct aaaatggt                                          28


<210>  33
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLN3 shRNA

<400>  33
ccggcgtagt ttactttgcc gagtactcga gtactcggca aagtaaacta cgtttttg         58


<210>  34
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KEAP1 shRNA

<400>  34
ccgggcgaat gatcacagca atgaactcga gttcattgct gtgatcattc gcttttttg        59


<210>  35
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-1

<400>  35
caccgaacct aagtgactaa aatcg                                             25


<210>  36
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-1

<400>  36
aaaccgattt tagtcactta ggttc                                             25


<210>  37
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-2

<400>  37
caccgcagta ggcgatggga gact                                              24


<210>  38
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-2

<400>  38
aaacagtctc ccatcgccta ctgc                                              24


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  up_arm

<400>  39
tgcaactctg tctctacggc                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  up_arm

<400>  40
agcaggcttc taagggtgac                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  down_arm

<400>  41
tgggagctag agcgaccatt                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  down_arm

<400>  42
cggtattgct gagcgtgact                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLN3_WT

<400>  43
agctgatact gaggaggcca                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLN3_WT

<400>  44
gggataccca gcatggacag                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Puro

<400>  45
atgaccgagt acaagcccac                                                   20


<210>  46
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Puro

<400>  46
tcaggcaccg ggcttgcg                                                     18


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLN3_mut

<400>  47
agctctgcgg tctcactcta                                                   20


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLN3_mut

<400>  48
ctggctcata cctagcgagt c                                                 21


