﻿                         序列表

<110>  和铂医药（上海）有限责任公司

<120>  靶向PD1和/或OX40的特异性结合蛋白

<130>  WO21144HB

<141>  2022-05-31

<150>  CN2021106735158
<151>  2021-06-17

<160>  143

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000150 HFWR1 Chothia


<400>  1
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  

<210>  2
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000324 HFWR1 Chothia


<400>  2
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Arg Lys Leu Ser Cys Ala Ala Ser 
            20                  25  

<210>  3
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000674 HFWR1 Chothia, PR001985 HFWR1 Chothia, PR006429


<220>
<223>  HFWR1 Chothia


<400>  3
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Val Ser 
            20                  25  

<210>  4
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR002063 HFWR1 Chothia, PR002067 HFWR1 Chothia


<400>  4
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  

<210>  5
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR003475 HFWR1 Chothia


<400>  5
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  

<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000150 HCDR1 Chothia


<400>  6
Gly Tyr Thr Phe Thr Asn Tyr 
1               5           

<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000324 HCDR1 Chothia


<400>  7
Gly Phe Thr Phe Ser Ser Phe 
1               5           

<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000674 HCDR1 Chothia, PR001985 HCDR1 Chothia


<400>  8
Gly Leu Thr Phe Ser Asp Asn 
1               5           

<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR002063 HCDR1 Chothia, PR002067 HCDR1 Chothia


<400>  9
Gly Phe Thr Phe Ser Ser Tyr 
1               5           

<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR003475 HCDR1 Chothia


<400>  10
Gly Tyr Thr Phe Thr Asp Ser 
1               5           

<210>  11
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000150 HFWR2 Chothia


<400>  11
Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
1               5                   10                  15      
Gly Gly Ile 
            

<210>  12
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000324 HFWR2 Chothia


<400>  12
Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
1               5                   10                  15      
Ala Tyr Ile 
            

<210>  13
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000674 HFWR2 Chothia, PR001985 HFWR2 Chothia, PR006429


<220>
<223>  HFWR2 Chothia


<400>  13
Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
1               5                   10                  15      
Ser Val Ile 
            

<210>  14
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR002067 HFWR2 Chothia


<400>  14
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15      
Ser Ala Ile 
            

<210>  15
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR003475 HFWR2 Chothia


<400>  15
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
1               5                   10                  15      
Gly Asp Met 
            

<210>  16
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000150 HCDR2 Chothia


<400>  16
Asn Pro Ser Asn Gly Gly 
1               5       

<210>  17
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000324 HCDR2 Chothia


<400>  17
Ser Ser Gly Ser Ser Thr 
1               5       

<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000674 HCDR2 Chothia, PR001985 HCDR2 Chothia


<400>  18
Trp Tyr Asp Gly Ser Lys 
1               5       

<210>  19
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR002067 HCDR2 Chothia


<400>  19
Ser Gly Arg Gly Gly Ser 
1               5       

<210>  20
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR003475 HCDR2 Chothia


<400>  20
Tyr Pro Asp Asn Gly Asp 
1               5       

<210>  21
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000150 HFWR3 Chothia


<400>  21
Thr Asn Phe Asn Glu Lys Phe Lys Asn Arg Val Thr Leu Thr Thr Asp 
1               5                   10                  15      
Ser Ser Thr Thr Thr Ala Tyr Met Glu Leu Lys Ser Leu Gln Phe Asp 
            20                  25                  30          
Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      

<210>  22
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000324 HFWR3 Chothia


<400>  22
Leu His Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      
Asn Pro Lys Asn Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu 
            20                  25                  30          
Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
        35                  40      

<210>  23
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000674 HFWR3 Chothia, PR001985 HFWR3 Chothia, PR006429


<220>
<223>  HFWR3 Chothia


<400>  23
Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      
Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Asn Met Arg Val Glu 
            20                  25                  30          
Asp Thr Ala Val Tyr Tyr Cys Ala Thr 
        35                  40      

<210>  24
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR002067 HFWR3 Chothia


<400>  24
Thr Phe Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      
Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          
Asp Thr Ala Met Tyr Tyr Cys Val Asp 
        35                  40      

<210>  25
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR003475 HFWR3 Chothia


<400>  25
Ser Ser Tyr Asn Gln Lys Phe Arg Glu Arg Val Thr Ile Thr Arg Asp 
1               5                   10                  15      
Thr Ser Thr Ser Thr Ala Tyr Leu Glu Leu Ser Ser Leu Arg Ser Glu 
            20                  25                  30          
Asp Thr Ala Val Tyr Tyr Cys Val Leu 
        35                  40      

<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000150 HCDR3 Chothia


<400>  26
Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr 
1               5                   10      

<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000324 HCDR3 Chothia


<400>  27
Trp Gly Asn Tyr Pro Tyr Tyr Ala Met Asp Tyr 
1               5                   10      

<210>  28
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000674 HCDR3 Chothia, PR001985 HCDR3 Chothia


<400>  28
Asn Ser Asp Tyr 
1               

<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR002067 HCDR3 Chothia


<400>  29
Gly Thr Thr Gly Thr Thr Asp Val Asp Tyr 
1               5                   10  

<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR003475 HCDR3 Chothia


<400>  30
Ala Pro Arg Trp Tyr Phe Ser Val 
1               5               

<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000150 HFWR4 Chothia


<400>  31
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      

<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000324 HFWR4 Chothia


<400>  32
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      

<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000674 HFWR4 Chothia, PR001985 HFWR4 Chothia, PR002067


<220>
<223>  HFWR4 Chothia, PR003475 HFWR4 Chothia, PR006429 HFWR4


<220>
<223>  Chothia, PR200526 HFWR4 Chothia


<400>  33
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210>  34
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000150 LFWR1 Chothia, PR000674 LFWR1 Chothia, PR001985


<220>
<223>  LFWR1 Chothia, PR006429 LFWR1 Chothia


<400>  34
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys 
            20              

<210>  35
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000324 LFWR1 Chothia


<400>  35
Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      
Glu Arg Val Thr Leu Thr Cys 
            20              

<210>  36
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR003475 LFWR1 Chothia


<400>  36
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys 
            20              

<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000150 LCDR1 Chothia


<400>  37
Arg Ala Ser Lys Gly Val Ser Thr Ser Gly Tyr Ser Tyr Leu His 
1               5                   10                  15  

<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000324 LCDR1 Chothia


<400>  38
Lys Ala Ser Glu Asn Val Val Thr Tyr Val Ser 
1               5                   10      

<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000674 LCDR1 Chothia, PR001985 LCDR1 Chothia, PR006429


<220>
<223>  LCDR1 Chothia


<400>  39
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      

<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR003475 LCDR1 Chothia


<400>  40
Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      

<210>  41
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000150 LFWR2 Chothia, PR000674 LFWR2 Chothia, PR001985


<220>
<223>  LFWR2 Chothia, PR006429 LFWR2 Chothia


<400>  41
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  

<210>  42
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000324 LFWR2 Chothia


<400>  42
Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  

<210>  43
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR003475 LFWR2 Chothia


<400>  43
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  

<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000150 LCDR2 Chothia


<400>  44
Leu Ala Ser Tyr Leu Glu Ser 
1               5           

<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000324 LCDR2 Chothia


<400>  45
Gly Ala Ser Asn Arg Tyr Thr 
1               5           

<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000674 LCDR2 Chothia, PR001985 LCDR2 Chothia, PR006429


<220>
<223>  LCDR2 Chothia


<400>  46
Asp Thr Ser Lys Arg Ala Thr 
1               5           

<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR003475 LCDR2 Chothia


<400>  47
Tyr Thr Ser Arg Leu Arg Ser 
1               5           

<210>  48
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000150 LFWR3 Chothia


<400>  48
Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          

<210>  49
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000324 LFWR3 Chothia


<400>  49
Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Ala Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr His Cys 
            20                  25                  30          

<210>  50
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000674 LFWR3 Chothia, PR001985 LFWR3 Chothia, PR006429


<220>
<223>  LFWR3 Chothia


<400>  50
Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          

<210>  51
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR003475 LFWR3 Chothia


<400>  51
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          

<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000150 LCDR3 Chothia


<400>  52
Gln His Ser Arg Asp Leu Pro Leu Thr 
1               5                   

<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000324 LCDR3 Chothia


<400>  53
Gly Gln Gly Tyr Ser Tyr Pro Tyr Thr 
1               5                   

<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000674 LCDR3 Chothia, PR001985 LCDR3 Chothia, PR006429


<220>
<223>  LCDR3 Chothia


<400>  54
Gln Gln His Asn Asn Trp Ile Phe Thr 
1               5                   

<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR003475 LCDR3 Chothia


<400>  55
Gln Gln Gly His Thr Leu Pro Pro Thr 
1               5                   

<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000150 LFWR4 Chothia


<400>  56
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  

<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000324 LFWR4 Chothia


<400>  57
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  

<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000674 LFWR4 Chothia, PR001985 LFWR4 Chothia, PR006429


<220>
<223>  LFWR4 Chothia


<400>  58
Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
1               5                   10  

<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR003475 LFWR4 Chothia


<400>  59
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  

<210>  60
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000150 VH


<400>  60
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210>  61
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000324 VH


<400>  61
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Ser Gly Ser Ser Thr Leu His Tyr Ala Asp Thr Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  
Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Trp Gly Asn Tyr Pro Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 

<210>  62
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000674 VH, PR001985 VH


<400>  62
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Leu Thr Phe Ser Asp Asn 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              
Ser Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Asn Met Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Asn Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser 
    

<210>  63
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR002067 VH


<400>  63
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Arg Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Val Asp Gly Thr Thr Gly Thr Thr Asp Val Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210>  64
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR003475 VH


<400>  64
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Ser 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Met Tyr Pro Asp Asn Gly Asp Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Arg Glu Arg Val Thr Ile Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Leu Ala Pro Arg Trp Tyr Phe Ser Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  65
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000150 VL


<400>  65
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          
Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      
Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     

<210>  66
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000324 VL


<400>  66
Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      
Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Val Val Thr Tyr 
            20                  25                  30          
Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr Ser Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  67
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000674 VL, PR001985 VL, PR006429 VL


<400>  67
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Thr Ser Lys Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Asn Asn Trp Ile Phe 
                85                  90                  95      
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         

<210>  68
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR003475 VL


<400>  68
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Thr Ser Arg Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly His Thr Leu Pro Pro 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  69
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000150 HC


<400>  69
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 
Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         

<210>  70
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000324 HC


<400>  70
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Ser Gly Ser Ser Thr Leu His Tyr Ala Asp Thr Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  
Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Trp Gly Asn Tyr Pro Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             
Gly Lys 
    450 

<210>  71
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000674 HC


<400>  71
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Leu Thr Phe Ser Asp Asn 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              
Ser Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Asn Met Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Asn Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             
Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         
Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 
Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             
Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         
Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440 

<210>  72
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR001985 HC


<400>  72
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Leu Thr Phe Ser Asp Asn 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              
Ser Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Asn Met Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Asn Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             

<210>  73
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR002067 HC


<400>  73
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Arg Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Val Asp Gly Thr Thr Gly Thr Thr Asp Val Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His 
        115                 120                 125             
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    130                 135                 140                 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
145                 150                 155                 160 
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                165                 170                 175     
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            180                 185                 190         
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        195                 200                 205             
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    210                 215                 220                 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
225                 230                 235                 240 
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                245                 250                 255     
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            260                 265                 270         
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        275                 280                 285             
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    290                 295                 300                 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
305                 310                 315                 320 
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                325                 330                 335     
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350     

<210>  74
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR003475 HC


<400>  74
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Ser 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Met Tyr Pro Asp Asn Gly Asp Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Arg Glu Arg Val Thr Ile Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Leu Ala Pro Arg Trp Tyr Phe Ser Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         

<210>  75
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000150 LC


<400>  75
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          
Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      
Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210>  76
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000324 LC


<400>  76
Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      
Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Val Val Thr Tyr 
            20                  25                  30          
Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr Ser Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  77
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR000674 LC, PR001985 LC, PR003787 Chain, PR006429 LC,


<220>
<223>  PR200528 Chain, PR200531 Chain, PR200536 Chain, PR200538


<220>
<223>  Chain, PR200600 Chain


<400>  77
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Thr Ser Lys Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Asn Asn Trp Ile Phe 
                85                  90                  95      
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  78
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR003475 LC


<400>  78
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Thr Ser Arg Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly His Thr Leu Pro Pro 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  79
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR003787 Chain


<400>  79
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Leu Thr Phe Ser Asp Asn 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              
Ser Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Asn Met Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Asn Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ala Glu Pro Lys Ser Ser 
        435                 440                 445             
Asp Lys Thr His Thr Pro Pro Pro Pro Pro Glu Val Gln Leu Leu Glu 
    450                 455                 460                 
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
465                 470                 475                 480 
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg 
                485                 490                 495     
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Arg 
            500                 505                 510         
Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile 
        515                 520                 525             
Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    530                 535                 540                 
Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Val Asp Gly Thr Thr Gly 
545                 550                 555                 560 
Thr Thr Asp Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                565                 570                 575     
Ser 
    

<210>  80
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200526 HFWR1 Chothia


<400>  80
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Gln 
1               5                   10                  15      
Ser Leu Arg Ile Ser Cys Lys Gly Ala 
            20                  25  

<210>  81
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR006429 HCDR1 Chothia


<400>  81
Gly Leu Thr Phe Ser Asp His 
1               5           

<210>  82
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200526 HCDR1 Chothia


<400>  82
Gly Tyr Ser Phe Ser Thr Tyr 
1               5           

<210>  83
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR002063 HFWR2 Chothia


<400>  83
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
1               5                   10                  15      
Ser Ala Ile 
            

<210>  84
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200526 HFWR2 Chothia


<400>  84
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
1               5                   10                  15      
Gly Ile Ile 
            

<210>  85
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR002063 HCDR2 Chothia


<400>  85
Ser Gly Gly Gly Gly Ser 
1               5       

<210>  86
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR006429 HCDR2 Chothia


<400>  86
Trp Tyr Asp Ser Ser Lys 
1               5       

<210>  87
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200526 HCDR2 Chothia


<400>  87
Tyr Pro Asp Asp Ser Asp 
1               5       

<210>  88
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR002063 HFWR3 Chothia


<400>  88
Thr Phe Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      
Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu 
            20                  25                  30          
Asp Thr Ala Val Tyr Tyr Cys Ala Asn 
        35                  40      

<210>  89
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200526 HFWR3 Chothia


<400>  89
Thr Arg Tyr Ser Pro Ser Phe Glu Gly Gln Val Thr Ile Ser Val Asp 
1               5                   10                  15      
Lys Ser Ile Thr Thr Ala Tyr Leu His Trp Ser Ser Leu Lys Ala Ser 
            20                  25                  30          
Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
        35                  40      

<210>  90
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR002063 HCDR3 Chothia


<400>  90
Gly Met Thr Gly Thr Thr Asp Val Asp Tyr 
1               5                   10  

<210>  91
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR006429 HCDR3 Chothia


<400>  91
Asn Asn Asp Tyr 
1               

<210>  92
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200526 HCDR3 Chothia


<400>  92
Leu Val Gly Gly Ala Pro Ala Tyr 
1               5               

<210>  93
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR002063 HFWR4 Chothia


<400>  93
Trp Gly Gln Gly Thr Arg Val Thr Val Ser Ser 
1               5                   10      

<210>  94
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200526 LFWR1 Chothia


<400>  94
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Ile Thr Ile Ser Cys 
            20          

<210>  95
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200526 LCDR1 Chothia


<400>  95
Ser Gly Ser Ser Ser Asp Ile Gly Arg Tyr Asp Tyr Val Ser 
1               5                   10                  

<210>  96
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200526 LFWR2 Chothia


<400>  96
Trp Tyr Gln His Tyr Pro Asp Lys Ala Pro Lys Leu Ile Ile Tyr 
1               5                   10                  15  

<210>  97
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200526 LCDR2 Chothia


<400>  97
Glu Val Lys His Arg Pro Ser 
1               5           

<210>  98
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200526 LFWR3 Chothia


<400>  98
Gly Ile Ser His Arg Phe Ser Ala Ser Lys Ser Gly Asn Thr Ala Ser 
1               5                   10                  15      
Leu Thr Ile Ser Glu Leu Gln Pro Gly Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          

<210>  99
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200526 LCDR3 Chothia


<400>  99
Ala Ser Tyr Thr Glu Ser Lys Thr Tyr Ile 
1               5                   10  

<210>  100
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200526 LFWR4 Chothia


<400>  100
Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
1               5                   10  

<210>  101
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR002063 VH


<400>  101
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Gly Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Asn Gly Met Thr Gly Thr Thr Asp Val Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Arg Val Thr Val Ser Ser 
        115                 

<210>  102
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR006429 VH


<400>  102
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Leu Thr Phe Ser Asp His 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              
Ser Val Ile Trp Tyr Asp Ser Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Asn Met Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Asn Asn Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser 
    

<210>  103
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200526 VH


<400>  103
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Gln 
1               5                   10                  15      
Ser Leu Arg Ile Ser Cys Lys Gly Ala Gly Tyr Ser Phe Ser Thr Tyr 
            20                  25                  30          
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ile Ile Tyr Pro Asp Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  
Glu Gly Gln Val Thr Ile Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  
Leu His Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Leu Val Gly Gly Ala Pro Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  104
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200526 VL


<400>  104
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Ile Thr Ile Ser Cys Ser Gly Ser Ser Ser Asp Ile Gly Arg Tyr 
            20                  25                  30          
Asp Tyr Val Ser Trp Tyr Gln His Tyr Pro Asp Lys Ala Pro Lys Leu 
        35                  40                  45              
Ile Ile Tyr Glu Val Lys His Arg Pro Ser Gly Ile Ser His Arg Phe 
    50                  55                  60                  
Ser Ala Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Glu Leu 
65                  70                  75                  80  
Gln Pro Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Thr Glu Ser 
                85                  90                  95      
Lys Thr Tyr Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 

<210>  105
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR002063 HC


<400>  105
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Gly Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Asn Gly Met Thr Gly Thr Thr Asp Val Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Arg Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His 
        115                 120                 125             
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    130                 135                 140                 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
145                 150                 155                 160 
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                165                 170                 175     
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            180                 185                 190         
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        195                 200                 205             
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    210                 215                 220                 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
225                 230                 235                 240 
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                245                 250                 255     
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            260                 265                 270         
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        275                 280                 285             
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    290                 295                 300                 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
305                 310                 315                 320 
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                325                 330                 335     
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350     

<210>  106
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR006429 HC


<400>  106
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Leu Thr Phe Ser Asp His 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              
Ser Val Ile Trp Tyr Asp Ser Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Asn Met Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Asn Asn Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             

<210>  107
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200526 HC


<400>  107
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Gln 
1               5                   10                  15      
Ser Leu Arg Ile Ser Cys Lys Gly Ala Gly Tyr Ser Phe Ser Thr Tyr 
            20                  25                  30          
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ile Ile Tyr Pro Asp Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  
Glu Gly Gln Val Thr Ile Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  
Leu His Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Leu Val Gly Gly Ala Pro Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         

<210>  108
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200526 LC


<400>  108
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Ile Thr Ile Ser Cys Ser Gly Ser Ser Ser Asp Ile Gly Arg Tyr 
            20                  25                  30          
Asp Tyr Val Ser Trp Tyr Gln His Tyr Pro Asp Lys Ala Pro Lys Leu 
        35                  40                  45              
Ile Ile Tyr Glu Val Lys His Arg Pro Ser Gly Ile Ser His Arg Phe 
    50                  55                  60                  
Ser Ala Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Glu Leu 
65                  70                  75                  80  
Gln Pro Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Thr Glu Ser 
                85                  90                  95      
Lys Thr Tyr Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         
Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             
Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 
Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 
Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     
Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         
Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             
Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     

<210>  109
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200528 Chain


<400>  109
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Leu Thr Phe Ser Asp His 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              
Ser Val Ile Trp Tyr Asp Ser Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Asn Met Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Asn Asn Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser Gly Gly 
        435                 440                 445             
Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    450                 455                 460                 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
465                 470                 475                 480 
Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp 
                485                 490                 495     
Val Ser Ala Ile Ser Gly Gly Gly Gly Ser Thr Phe Tyr Ala Asp Ser 
            500                 505                 510         
Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
        515                 520                 525             
Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    530                 535                 540                 
Cys Ala Asn Gly Met Thr Gly Thr Thr Asp Val Asp Tyr Trp Gly Gln 
545                 550                 555                 560 
Gly Thr Arg Val Thr Val Ser Ser 
                565             

<210>  110
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200531 Chain


<400>  110
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Leu Thr Phe Ser Asp His 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              
Ser Val Ile Trp Tyr Asp Ser Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Asn Met Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Asn Asn Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser Gly Gly 
        435                 440                 445             
Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    450                 455                 460                 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
465                 470                 475                 480 
Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                485                 490                 495     
Val Ser Ala Ile Ser Gly Arg Gly Gly Ser Thr Phe Tyr Ala Asp Ser 
            500                 505                 510         
Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
        515                 520                 525             
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr 
    530                 535                 540                 
Cys Val Asp Gly Thr Thr Gly Thr Thr Asp Val Asp Tyr Trp Gly Gln 
545                 550                 555                 560 
Gly Thr Leu Val Thr Val Ser Ser 
                565             

<210>  111
<211>  699
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200536 Chain


<400>  111
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Leu Thr Phe Ser Asp His 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              
Ser Val Ile Trp Tyr Asp Ser Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Asn Met Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Asn Asn Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             
Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         
Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 
Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             
Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         
Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly Ser Gly Gly Ser Glu Val 
        435                 440                 445             
Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    450                 455                 460                 
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
465                 470                 475                 480 
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala 
                485                 490                 495     
Ile Ser Gly Arg Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Arg Gly 
            500                 505                 510         
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        515                 520                 525             
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Val Asp 
    530                 535                 540                 
Gly Thr Thr Gly Thr Thr Asp Val Asp Tyr Trp Gly Gln Gly Thr Leu 
545                 550                 555                 560 
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     
Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
            580                 585                 590         
Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        595                 600                 605             
Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    610                 615                 620                 
Leu Glu Trp Val Ser Ala Ile Ser Gly Arg Gly Gly Ser Thr Phe Tyr 
625                 630                 635                 640 
Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                645                 650                 655     
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            660                 665                 670         
Met Tyr Tyr Cys Val Asp Gly Thr Thr Gly Thr Thr Asp Val Asp Tyr 
        675                 680                 685             
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    690                 695                 

<210>  112
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200538 Chain


<400>  112
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Arg Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Val Asp Gly Thr Thr Gly Thr Thr Asp Val Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 
Val Val Gln Pro Gly Lys Ser Leu Arg Leu Ser Cys Thr Val Ser Gly 
145                 150                 155                 160 
Leu Thr Phe Ser Asp His Gly Met His Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     
Arg Gly Leu Glu Trp Met Ser Val Ile Trp Tyr Asp Ser Ser Lys Lys 
            180                 185                 190         
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Asn Met Arg Val Glu Asp 
    210                 215                 220                 
Thr Ala Val Tyr Tyr Cys Ala Thr Asn Asn Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
                245                 250                 255     
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
            260                 265                 270         
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
        275                 280                 285             
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
    290                 295                 300                 
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
305                 310                 315                 320 
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
                325                 330                 335     
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
            340                 345                 350         
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro 
        355                 360                 365             
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    370                 375                 380                 
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
385                 390                 395                 400 
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                405                 410                 415     
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            420                 425                 430         
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        435                 440                 445             
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    450                 455                 460                 
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
465                 470                 475                 480 
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                485                 490                 495     
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            500                 505                 510         
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        515                 520                 525             
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    530                 535                 540                 
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
545                 550                 555                 560 
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570                 575     
Lys 
    

<210>  113
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200539 Chain


<400>  113
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Leu Thr Phe Ser Asp His 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              
Ser Val Ile Trp Tyr Asp Ser Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Asn Met Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Asn Asn Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215     

<210>  114
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200539 Chain


<400>  114
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Thr Ser Lys Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Asn Asn Trp Ile Phe 
                85                  90                  95      
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    210                 215                 220                 
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
225                 230                 235                 240 
Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
                245                 250                 255     
Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Arg Gly Gly Ser Thr 
            260                 265                 270         
Phe Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        275                 280                 285             
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    290                 295                 300                 
Thr Ala Met Tyr Tyr Cys Val Asp Gly Thr Thr Gly Thr Thr Asp Val 
305                 310                 315                 320 
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys 
                325                 330                 335     
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
            340                 345                 350         
Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        355                 360                 365             
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    370                 375                 380                 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
385                 390                 395                 400 
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                405                 410                 415     
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            420                 425                 430         
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        435                 440                 445             
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    450                 455                 460                 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
465                 470                 475                 480 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                485                 490                 495     
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            500                 505                 510         
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        515                 520                 525             
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    530                 535                 540                 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
545                 550                 555                 560 
Leu Ser Pro Gly Lys 
                565 

<210>  115
<211>  825
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR200600 Chain


<400>  115
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Leu Thr Phe Ser Asp His 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              
Ser Val Ile Trp Tyr Asp Ser Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Asn Met Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Asn Asn Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Ser 
        435                 440                 445             
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
    450                 455                 460                 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
465                 470                 475                 480 
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
                485                 490                 495     
Ser Ala Ile Ser Gly Gly Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val 
            500                 505                 510         
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
        515                 520                 525             
Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
    530                 535                 540                 
Ala Asn Gly Met Thr Gly Thr Thr Asp Val Asp Tyr Trp Gly Gln Gly 
545                 550                 555                 560 
Thr Arg Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                565                 570                 575     
Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            580                 585                 590         
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
        595                 600                 605             
Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp 
    610                 615                 620                 
Val Ser Ala Ile Ser Gly Gly Gly Gly Ser Thr Phe Tyr Ala Asp Ser 
625                 630                 635                 640 
Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
                645                 650                 655     
Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            660                 665                 670         
Cys Ala Asn Gly Met Thr Gly Thr Thr Asp Val Asp Tyr Trp Gly Gln 
        675                 680                 685             
Gly Thr Arg Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    690                 695                 700                 
Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
705                 710                 715                 720 
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                725                 730                 735     
Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu 
            740                 745                 750         
Trp Val Ser Ala Ile Ser Gly Gly Gly Gly Ser Thr Phe Tyr Ala Asp 
        755                 760                 765             
Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
    770                 775                 780                 
Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
785                 790                 795                 800 
Tyr Cys Ala Asn Gly Met Thr Gly Thr Thr Asp Val Asp Tyr Trp Gly 
                805                 810                 815     
Gln Gly Thr Arg Val Thr Val Ser Ser 
            820                 825 

<210>  117
<211>  15
<212>  PRT
<213>  Artificial Sequence

<400>  117
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Pro Pro Pro Pro Pro 
1               5                   10                  15  

<210>  117
<211>  6
<212>  PRT
<213>  Artificial Sequence

<400>  117
Gly Gly Ser Gly Gly Ser 
1               5       

<210>  118
<211>  15
<212>  PRT
<213>  Artificial Sequence

<400>  118
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

<210>  119
<211>  10
<212>  PRT
<213>  Artificial Sequence

<400>  119
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  

<210>  120
<211>  2
<212>  PRT
<213>  Artificial Sequence

<400>  120
Gly Ser 
1       

<210>  121
<211>  4
<212>  PRT
<213>  Artificial Sequence

<400>  121
Gly Ser Gly Ser 
1               

<210>  122
<211>  5
<212>  PRT
<213>  Artificial Sequence

<400>  122
Gly Gly Gly Gly Ser 
1               5   

<210>  123
<211>  7
<212>  PRT
<213>  Artificial Sequence

<400>  123
Gly Gly Gly Gly Ser Gly Ser 
1               5           

<210>  124
<211>  20
<212>  PRT
<213>  Artificial Sequence

<400>  124
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser 
            20  

<210>  125
<211>  25
<212>  PRT
<213>  Artificial Sequence

<400>  125
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  

<210>  126
<211>  10
<212>  PRT
<213>  Artificial Sequence

<400>  126
Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10  

<210>  127
<211>  15
<212>  PRT
<213>  Artificial Sequence

<400>  127
Gly Gly Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  

<210>  128
<211>  17
<212>  PRT
<213>  Artificial Sequence

<400>  128
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Pro Pro Pro Pro Pro Arg 
1               5                   10                  15      
Thr 
    

<210>  129
<211>  18
<212>  PRT
<213>  Artificial Sequence

<400>  129
Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      
Arg Thr 
        

<210>  130
<211>  18
<212>  PRT
<213>  Artificial Sequence

<400>  130
Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Pro Pro Pro Pro Pro 
1               5                   10                  15      
Arg Thr 
        

<210>  131
<211>  19
<212>  PRT
<213>  Artificial Sequence

<400>  131
Lys Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Pro Pro Pro Pro 
1               5                   10                  15      
Pro Arg Thr 
            

<210>  132
<211>  19
<212>  PRT
<213>  Artificial Sequence

<400>  132
Lys Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Pro Pro Pro Pro 
1               5                   10                  15      
Pro Ala Ser 
            

<210>  133
<211>  9
<212>  PRT
<213>  Artificial Sequence

<400>  133
Arg Thr Gly Gly Gly Gly Ser Lys Leu 
1               5                   

<210>  134
<211>  19
<212>  PRT
<213>  Artificial Sequence

<400>  134
Arg Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      
Ser Lys Leu 
            

<210>  135
<211>  29
<212>  PRT
<213>  Artificial Sequence

<400>  135
Arg Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Leu 
            20                  25                  

<210>  136
<211>  15
<212>  PRT
<213>  Artificial Sequence

<400>  136
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  

<210>  137
<211>  15
<212>  PRT
<213>  Artificial Sequence

<400>  137
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  

<210>  138
<211>  12
<212>  PRT
<213>  Artificial Sequence

<400>  138
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          

<210>  139
<211>  12
<212>  PRT
<213>  Artificial Sequence

<400>  139
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          

<210>  140
<211>  12
<212>  PRT
<213>  Artificial Sequence

<400>  140
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          

<210>  141
<211>  24
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  141
ggtgtccagt gtsaggtgca gctg                                               24

<210>  142
<211>  29
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  142
aatccctggg cactgaagag acggtgacc                                          29

<210>  143
<211>  327
<212>  PRT
<213>  Artificial Sequence

<400>  143
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys 
                325         

