﻿                         序列表

<110>  南京蓝盾生物科技有限公司

<120>  具有增强的ADCC效应的抗CD70 抗体及其应用

<160>  90

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  1
Gly Ser Ile Phe Ser Ile Tyr Leu 
1               5               

<210>  2
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  2
Ala Gly Thr Phe Arg Phe Lys Thr 
1               5               

<210>  3
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  3
Gly Phe Thr Thr Ser Thr Tyr Asp 
1               5               

<210>  4
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  4
Gly Phe Thr Phe Arg Ser Ala Val 
1               5               

<210>  5
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  5
Gly Ser Ile Phe Ser Ile Tyr Ala 
1               5               

<210>  6
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  6
Gly Phe Thr Phe Ser Ser Val Val 
1               5               

<210>  7
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  7
Gly Ser Ile Phe Ser Ile Tyr Ala 
1               5               

<210>  8
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  8
Ala Ser Gly Ser Thr Ser Ser Ile Tyr Ala 
1               5                   10  

<210>  9
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  9
Gly Ser Ser Phe Ser Ser Tyr Ala 
1               5               

<210>  10
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  10
Gly Ser Ile Phe Asn Ile Tyr Ala 
1               5               

<210>  11
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  11
Gly Phe Ser Leu Asp Tyr Tyr Phe 
1               5               

<210>  12
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  12
Gly Phe Thr Leu Asp Tyr Tyr Ala 
1               5               

<210>  13
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  13
Gly Phe Thr Leu Asp Tyr Tyr Ala 
1               5               

<210>  14
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  14
Gly Phe Thr Leu Ser Ser Tyr Ala 
1               5               

<210>  15
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  15
Ile Thr Ser Asp Gly Ile Ala 
1               5           

<210>  16
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  16
Ile Thr Ser Gly Gly Ser Thr 
1               5           

<210>  17
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  17
Ile Asp Ser Val His Gly Ile Thr 
1               5               

<210>  18
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  18
Ile Thr Ser Gly Gly Asp Val 
1               5           

<210>  19
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  19
Ile Thr Asn Ala Gly Gly Thr 
1               5           

<210>  20
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  20
Ile Thr Asp Gly Gly Val Thr 
1               5           

<210>  21
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  21
Ile Thr Asn Ala Gly Gly Thr 
1               5           

<210>  22
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  22
Val Thr Asn Ala Gly Ser Thr 
1               5           

<210>  23
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  23
Ile Thr Asn Val Gly Ser Thr 
1               5           

<210>  24
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  24
Ile Val Tyr Gly Gly Arg Ile 
1               5           

<210>  25
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  25
Ile Ser Ser Ser Asp Gly Ser Thr 
1               5               

<210>  26
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  26
Ile Ser Ser Ser Asp Val Ser Thr 
1               5               

<210>  27
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  27
Ile Thr Asn Ser Gly Ser Thr 
1               5           

<210>  28
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  28
Val Thr Asn Val Gly Ser Thr 
1               5           

<210>  29
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  29
Asn Ala Gln Ser Arg Ala Thr Arg Glu Gln Val Gly Ile Lys Gly 
1               5                   10                  15  

<210>  30
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  30
Asn Ala Tyr Tyr Asp Asp Ile 
1               5           

<210>  31
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  31
Asn Thr Ser Pro Arg Val Pro Arg Leu Arg 
1               5                   10  

<210>  32
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  32
Asn Ala Tyr Tyr Leu Asp Tyr 
1               5           

<210>  33
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  33
Asn Ala Ile Glu Glu Glu Val Glu Pro Gly Thr Asp Arg Tyr Arg Tyr 
1               5                   10                  15      
Leu Glu Val 
            

<210>  34
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  34
Asn Ala Tyr Tyr Leu Asp Tyr 
1               5           

<210>  35
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  35
Asn Val Leu His Glu Ser Thr Val Val Ala Gly Pro Val Gly Glu Asn 
1               5                   10                  15      
Arg Tyr Glu Tyr Gln Glu Ile 
            20              

<210>  36
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  36
Asn Val Ile Glu Glu Arg Thr Val Asp Ser Gly Asp Thr Gln Arg Thr 
1               5                   10                  15      
Arg Tyr Lys Tyr Phe Glu Val 
            20              

<210>  37
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  37
Asn Val Leu His Glu Ser Thr Val Ala Ala Gly Pro Val Gly Glu Lys 
1               5                   10                  15      
Arg Tyr Asn Tyr Glu Glu Ile 
            20              

<210>  38
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  38
Asn Ala Val Asp Glu Ile Pro Ser Glu Gly Glu Arg Tyr Arg Tyr Leu 
1               5                   10                  15      
Glu Val 
        

<210>  39
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  39
Ala Ala Arg Phe Arg Ser Asp Tyr Val Cys Tyr Pro Glu Gly Ser Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  40
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  40
Ala Ala Arg Tyr Ile Thr Asp Tyr Met Cys Tyr Pro Glu Gly Gly Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  41
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  41
Tyr Val Leu His Glu Ser Thr Val Thr Ala Gly Pro Val Gly Glu Lys 
1               5                   10                  15      
Arg Tyr Arg Tyr Asp Glu Val 
            20              

<210>  42
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  42
Tyr Val Leu His Glu Ser Thr Val Val Asp Asn Pro Val Gly Glu Lys 
1               5                   10                  15      
Arg Tyr Lys Tyr Glu Glu Ile 
            20              

<210>  43
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  43
ggaagcatct tcagtatcta tctc                                               24

<210>  44
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  44
gcaggaacct tcagattcaa aact                                               24

<210>  45
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  45
ggattcacca ccagtaccta tgac                                               24

<210>  46
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  46
ggattcacct tcagaagcgc ggtc                                               24

<210>  47
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  47
ggaagcatct tcagtatcta tgcc                                               24

<210>  48
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  48
ggattcacct tcagtagcgt agtc                                               24

<210>  49
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  49
ggaagcatct tcagtatcta tgcc                                               24

<210>  50
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  50
gcctctggaa gcacgagcag tatctatgcc                                         30

<210>  51
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  51
ggaagcagct tcagttccta tgcc                                               24

<210>  52
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  52
ggcagcatct tcaatatcta tgcc                                               24

<210>  53
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  53
ggattcagtt tggattatta tttc                                               24

<210>  54
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  54
ggattcactt tggattatta tgcc                                               24

<210>  55
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  55
ggaagcatct ccagtatcta tgcc                                               24

<210>  56
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  56
ggattcacct tgagtagcta tgcc                                               24

<210>  57
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  57
attactagtg atggtattgc a                                                  21

<210>  58
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  58
attaccagtg gtggtagtac a                                                  21

<210>  59
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  59
atcgatagtg ttcatggtat caca                                               24

<210>  60
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  60
attactagtg gtggcgacgt a                                                  21

<210>  61
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  61
attactaatg ctggtggcac a                                                  21

<210>  62
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  62
attactgatg gtggcgtcac a                                                  21

<210>  63
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  63
attactaacg ctggtggcac a                                                  21

<210>  64
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  64
gttactaatg ctggtagtac a                                                  21

<210>  65
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  65
ataactaatg ttggtagtac a                                                  21

<210>  66
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  66
atagtatatg gtggtaggat a                                                  21

<210>  67
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  67
attagtagta gtgatggtag caca                                               24

<210>  68
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  68
attagtagta gtgatgtgag caca                                               24

<210>  69
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  69
attactaata gtggtagcac t                                                  21

<210>  70
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  70
gttactaatg ttggtagcac a                                                  21

<210>  71
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  71
aatgctcagt ctagagcgac tcgcgaacaa gtcggtatta aaggc                        45

<210>  72
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  72
aatgcttatt acgacgatat t                                                  21

<210>  73
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  73
aacacaagtc ctagggtgcc ccgtctacgc                                         30

<210>  74
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  74
aatgcttact atttggacta c                                                  21

<210>  75
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  75
aatgcaattg aggaggaggt agaacctggt actgaccgct acaggtatct cgaagtt           57

<210>  76
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  76
aacgcatact atttggatta c                                                  21

<210>  77
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  77
aatgtcctcc atgagagtac ggtagtagct ggtcccgtgg gcgagaatcg ctacgagtat        60
caagaaatt                                                                69

<210>  78
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  78
aatgtcatag aggaacgtac ggtagatagt ggtgataccc aaagaactcg ctacaagtat        60
ttcgaagtt                                                                69

<210>  79
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  79
aatgtcctcc atgagagtac ggtagctgct ggtcccgtgg gcgagaagcg ctacaattac        60
gaagaaatt                                                                69

<210>  80
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  80
aatgcagttg acgaaatccc gtcggagggt gagcgctaca ggtatctcga agtt              54

<210>  81
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  81
gcagctcgat ttcgttcaga ctatgtgtgt tatcccgaag gatcgtatga ctac              54

<210>  82
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  82
gcagcacgct acataacaga ctatatgtgt tacccagagg gtgggtatga ctac              54

<210>  83
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  83
tatgtcctcc atgagagtac ggtaacagct ggtcccgtgg gcgagaagcg ctacaggtat        60
gatgaagtt                                                                69

<210>  84
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  84
tatgtcctcc atgagagtac ggtagtagat aatcccgtgg gcgagaagcg ctacaagtat        60
gaagaaatt                                                                69

<210>  85
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  85
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Tyr 
            20                  25                  30          
Leu Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              
Ala Val Ile Thr Ser Asp Gly Ile Ala Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Val Ser Arg Asp Asp Ala Lys Arg Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys Asn 
                85                  90                  95      
Ala Gln Ser Arg Ala Thr Arg Glu Gln Val Gly Ile Lys Gly Trp Gly 
            100                 105                 110         
Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     

<210>  86
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  86
cagttgcagc tcgtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc        60
tcctgtgcag cctctggaag catcttcagt atctatctca tggcctggta ccgccaggct       120
ccagggaagg agcgcgagct ggtcgcagtt attactagtg atggtattgc aaactatgca       180
gactccgtga agggccgatt caccgtctcc agagacgacg ccaagagaac cgtgtatctg       240
caaatgaaca gcctgaaacc tgaggacacg gccgactatt actgtaatgc tcagtctaga       300
gcgactcgcg aacaagtcgg tattaaaggc tggggccagg ggacccaggt caccgtctcc       360
tca                                                                     363

<210>  87
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  87
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Gly Thr Phe Arg Phe Lys 
            20                  25                  30          
Thr Met Gly Trp His Arg Gln Val Gln Gly Lys Gln Arg Glu Leu Leu 
        35                  40                  45              
Ala Leu Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Phe Val Glu 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Leu Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      
Ala Tyr Tyr Asp Asp Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         
Ser 
    

<210>  88
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  88
cagttgcagc tcgtggagtc tgggggaggc ttggtgcagc cgggggggtc tctgagactc        60
tcctgtgcag cctccgcagg aaccttcaga ttcaaaacta tgggctggca ccgccaggtt       120
caagggaaac agcgcgaatt gctcgcatta attaccagtg gtggtagtac aaattatgca       180
gacttcgtcg agggccgatt caccatctcc agagacaacg ccaagaacct ggtgtatttg       240
caaatgaaca gcctgaaacc tgaggacacg gccgtctatt attgtaatgc ttattacgac       300
gatatttggg gccaggggac ccaggtcacc gtctcctca                              339

<210>  89
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  89
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Thr Ser Thr Tyr 
            20                  25                  30          
Asp Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              
Ala Ile Ile Asp Ser Val His Gly Ile Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Asn Thr Ser Pro Arg Val Pro Arg Leu Arg Trp Gly Gln Gly Thr Gln 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  90
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  90
cagttgcagc tcgtcgagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc        60
tcctgtgcag cctctggatt caccaccagt acctatgaca tgaggtggta ccgccaggct       120
ccagggaagg agcgcgagtt ggtcgcaatt atcgatagtg ttcatggtat cacaaactat       180
gcagactccg tgaagggccg attcaccatc tccagagaca atgccaggaa cacggtgtat       240
ctacaaatga acaacctgaa acctgaggac acggccgtgt attactgtaa cacaagtcct       300
agggtgcccc gtctacgctg gggccagggg acccaggtca ccgtctcctc a                351

