                         SEQUENCE LISTING

<110>  The Broad Institute, Inc.
       Massachusetts Institute of Technology
       The General Hospital Corporation
 
<120>  METHODS AND COMPOSITIONS FOR MODULATING STING SIGNALING AND 
       INNATE IMMUNE RESPONSES

<130>  B1195.70133WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 63/304,554
<151>  2022-01-28

<150>  US 63/209,316
<151>  2021-06-10

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  2893
<212>  DNA
<213>  Homo sapiens

<400>  1
gcgccagctc gtagcagggg agcgcccgcg gcgtcgggtt tgggctggag gtcgccatgg       60

ggcgaggcag cggcaccttc gagcgtctcc tagacaaggc gaccagccag ctcctgttgg      120

agacagattg ggagtccatt ttgcagatct gcgacctgat ccgccaaggg gacacacaag      180

caaaatatgc tgtgaattcc atcaagaaga aagtcaacga caagaaccca cacgtcgcct      240

tgtatgccct ggaggtcatg gaatctgtgg taaagaactg tggccagaca gttcatgatg      300

aggtggccaa caagcagacc atggaggagc tgaaggacct gctgaagaga caagtggagg      360

taaacgtccg taacaagatc ctgtacctga tccaggcctg ggcgcatgcc ttccggaacg      420

agcccaagta caaggtggtc caggacacct accagatcat gaaggtggag gggcacgtct      480

ttccagaatt caaagagagc gatgccatgt ttgctgccga gagagcccca gactgggtgg      540

acgctgagga atgccaccgc tgcagggtgc agttcggggt gatgacccgt aagcaccact      600

gccgggcgtg tgggcagata ttctgtggaa agtgttcttc caagtactcc accatcccca      660

agtttggcat cgagaaggag gtgcgcgtgt gtgagccctg ctacgagcag ctgaacagga      720

aagcggaggg aaaggccact tccaccactg agctgccccc cgagtacctg accagccccc      780

tgtctcagca gtcccagctg ccccccaaga gggacgagac ggccctgcag gaggaggagg      840

agctgcagct ggccctggcg ctgtcacagt cagaggcgga ggagaaggag aggctgagac      900

agaagtccac gtacacttcg taccccaagg cggagcccat gccctcggcc tcctcagcgc      960

cccccgccag cagcctgtac tcttcacctg tgaactcgtc ggcgcctctg gctgaggaca     1020

tcgaccctga gctcgcacgg tatctcaacc ggaactactg ggagaagaag caggaggagg     1080

ctcgcaagag ccccacgcca tctgcgcccg tgcccctgac ggagccggct gcacagcctg     1140

gggaagggca cgcagccccc accaacgtgg tggagaaccc cctcccggag acagactctc     1200

agcccattcc tccctctggt ggccccttta gtgagccaca gttccacaat ggcgagtctg     1260

aggagagcca cgagcagttc ctgaaggcgc tgcagaacgc cgtcaccacc ttcgtgaacc     1320

gcatgaagag taaccacatg cggggccgca gcatcaccaa tgactcggcc gtgctctcac     1380

tcttccagtc catcaacggc atgcacccgc agctgctgga gctgctcaac cagctggacg     1440

agcgcaggct gtactatgag gggctgcagg acaagctggc acagatccgc gatgcccggg     1500

gggcgctgag tgccctgcgc gaagagcacc gggagaagct tcgccgggca gccgaggagg     1560

cagagcgcca gcgccagatc cagctggccc agaagctgga gataatgcgg cagaagaagc     1620

aggagtacct ggaggtgcag aggcagctgg ccatccagcg cctgcaggag caggagaagg     1680

agcggcagat gcggctggag cagcagaagc agacggtcca gatgcgcgcg cagatgcccg     1740

ccttccccct gccctacgcc cagctccagg ccatgcccgc agccggaggt gtgctctacc     1800

agccctcggg accagccagc ttccccagca ccttcagccc tgccggctcg gtggagggct     1860

ccccaatgca cggcgtgtac atgagccagc cggcccctgc cgctggcccc taccccagca     1920

tgcccagcac tgcggctgat cccagcatgg tgagtgccta catgtaccca gcaggggcca     1980

ctggggcgca ggcggccccc caggcccagg ccggacccac cgccagcccc gcttactcat     2040

cctaccagcc tactcccaca gcgggctacc agaacgtggc ctcccaggcc ccacagagcc     2100

tcccggccat ctctcagcct ccgcagtcca gcaccatggg ctacatgggg agccagtcag     2160

tctccatggg ctaccagcct tacaacatgc agaatctcat gaccaccctc ccaagccagg     2220

atgcgtctct gccaccccag cagccctaca tcgcggggca gcagcccatg taccagcaga     2280

tggcaccctc tggcggtccc ccccagcagc agccccccgt ggcccagcaa ccgcaggcac     2340

aggggccgcc ggcacagggc agcgaggccc agctcatttc attcgactga cccaggccat     2400

gctcacgtcc ggagtaacac tacatacagt tcacctgaaa cgcctcgtct ctaactgccg     2460

tcgtcctgcc tccctgtcct ctactgccgg tagtgtccct tctctgcgag tgaggggggg     2520

ccttcacccc aagcccacct cccttgtcct cagcctactg cagtccctga gttagtctct     2580

gctttctttc cccagggctg ggccatgggg agggaaggac tttctcccag gggaagcccc     2640

cagccctgtg ggtcatggtc tgtgagaggt ggcaggaatg gggaccctca ccccccaagc     2700

agcctgtgcc ctctggccgc actgtgagct ggctgtggtg tctgggtgtg gcctggggct     2760

ccctctgcag gggcctctct cggcagccac agccaagggt ggaggcttca ggtctccagc     2820

ttctctgctt ctcagctgcc atctccagtg ccccagaatg gtacagcgat aataaaatgt     2880

atttcagaaa gca                                                        2893


<210>  2
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Arg Gly Ser Gly Thr Phe Glu Arg Leu Leu Asp Lys Ala Thr 
1               5                   10                  15      


Ser Gln Leu Leu Leu Glu Thr Asp Trp Glu Ser Ile Leu Gln Ile Cys 
            20                  25                  30          


Asp Leu Ile Arg Gln Gly Asp Thr Gln Ala Lys Tyr Ala Val Asn Ser 
        35                  40                  45              


Ile Lys Lys Lys Val Asn Asp Lys Asn Pro His Val Ala Leu Tyr Ala 
    50                  55                  60                  


Leu Glu Val Met Glu Ser Val Val Lys Asn Cys Gly Gln Thr Val His 
65                  70                  75                  80  


Asp Glu Val Ala Asn Lys Gln Thr Met Glu Glu Leu Lys Asp Leu Leu 
                85                  90                  95      


Lys Arg Gln Val Glu Val Asn Val Arg Asn Lys Ile Leu Tyr Leu Ile 
            100                 105                 110         


Gln Ala Trp Ala His Ala Phe Arg Asn Glu Pro Lys Tyr Lys Val Val 
        115                 120                 125             


Gln Asp Thr Tyr Gln Ile Met Lys Val Glu Gly His Val Phe Pro Glu 
    130                 135                 140                 


Phe Lys Glu Ser Asp Ala Met Phe Ala Ala Glu Arg Ala Pro Asp Trp 
145                 150                 155                 160 


Val Asp Ala Glu Glu Cys His Arg Cys Arg Val Gln Phe Gly Val Met 
                165                 170                 175     


Thr Arg Lys His His Cys Arg Ala Cys Gly Gln Ile Phe Cys Gly Lys 
            180                 185                 190         


Cys Ser Ser Lys Tyr Ser Thr Ile Pro Lys Phe Gly Ile Glu Lys Glu 
        195                 200                 205             


Val Arg Val Cys Glu Pro Cys Tyr Glu Gln Leu Asn Arg Lys Ala Glu 
    210                 215                 220                 


Gly Lys Ala Thr Ser Thr Thr Glu Leu Pro Pro Glu Tyr Leu Thr Ser 
225                 230                 235                 240 


Pro Leu Ser Gln Gln Ser Gln Leu Pro Pro Lys Arg Asp Glu Thr Ala 
                245                 250                 255     


Leu Gln Glu Glu Glu Glu Leu Gln Leu Ala Leu Ala Leu Ser Gln Ser 
            260                 265                 270         


Glu Ala Glu Glu Lys Glu Arg Leu Arg Gln Lys Ser Thr Tyr Thr Ser 
        275                 280                 285             


Tyr Pro Lys Ala Glu Pro Met Pro Ser Ala Ser Ser Ala Pro Pro Ala 
    290                 295                 300                 


Ser Ser Leu Tyr Ser Ser Pro Val Asn Ser Ser Ala Pro Leu Ala Glu 
305                 310                 315                 320 


Asp Ile Asp Pro Glu Leu Ala Arg Tyr Leu Asn Arg Asn Tyr Trp Glu 
                325                 330                 335     


Lys Lys Gln Glu Glu Ala Arg Lys Ser Pro Thr Pro Ser Ala Pro Val 
            340                 345                 350         


Pro Leu Thr Glu Pro Ala Ala Gln Pro Gly Glu Gly His Ala Ala Pro 
        355                 360                 365             


Thr Asn Val Val Glu Asn Pro Leu Pro Glu Thr Asp Ser Gln Pro Ile 
    370                 375                 380                 


Pro Pro Ser Gly Gly Pro Phe Ser Glu Pro Gln Phe His Asn Gly Glu 
385                 390                 395                 400 


Ser Glu Glu Ser His Glu Gln Phe Leu Lys Ala Leu Gln Asn Ala Val 
                405                 410                 415     


Thr Thr Phe Val Asn Arg Met Lys Ser Asn His Met Arg Gly Arg Ser 
            420                 425                 430         


Ile Thr Asn Asp Ser Ala Val Leu Ser Leu Phe Gln Ser Ile Asn Gly 
        435                 440                 445             


Met His Pro Gln Leu Leu Glu Leu Leu Asn Gln Leu Asp Glu Arg Arg 
    450                 455                 460                 


Leu Tyr Tyr Glu Gly Leu Gln Asp Lys Leu Ala Gln Ile Arg Asp Ala 
465                 470                 475                 480 


Arg Gly Ala Leu Ser Ala Leu Arg Glu Glu His Arg Glu Lys Leu Arg 
                485                 490                 495     


Arg Ala Ala Glu Glu Ala Glu Arg Gln Arg Gln Ile Gln Leu Ala Gln 
            500                 505                 510         


Lys Leu Glu Ile Met Arg Gln Lys Lys Gln Glu Tyr Leu Glu Val Gln 
        515                 520                 525             


Arg Gln Leu Ala Ile Gln Arg Leu Gln Glu Gln Glu Lys Glu Arg Gln 
    530                 535                 540                 


Met Arg Leu Glu Gln Gln Lys Gln Thr Val Gln Met Arg Ala Gln Met 
545                 550                 555                 560 


Pro Ala Phe Pro Leu Pro Tyr Ala Gln Leu Gln Ala Met Pro Ala Ala 
                565                 570                 575     


Gly Gly Val Leu Tyr Gln Pro Ser Gly Pro Ala Ser Phe Pro Ser Thr 
            580                 585                 590         


Phe Ser Pro Ala Gly Ser Val Glu Gly Ser Pro Met His Gly Val Tyr 
        595                 600                 605             


Met Ser Gln Pro Ala Pro Ala Ala Gly Pro Tyr Pro Ser Met Pro Ser 
    610                 615                 620                 


Thr Ala Ala Asp Pro Ser Met Val Ser Ala Tyr Met Tyr Pro Ala Gly 
625                 630                 635                 640 


Ala Thr Gly Ala Gln Ala Ala Pro Gln Ala Gln Ala Gly Pro Thr Ala 
                645                 650                 655     


Ser Pro Ala Tyr Ser Ser Tyr Gln Pro Thr Pro Thr Ala Gly Tyr Gln 
            660                 665                 670         


Asn Val Ala Ser Gln Ala Pro Gln Ser Leu Pro Ala Ile Ser Gln Pro 
        675                 680                 685             


Pro Gln Ser Ser Thr Met Gly Tyr Met Gly Ser Gln Ser Val Ser Met 
    690                 695                 700                 


Gly Tyr Gln Pro Tyr Asn Met Gln Asn Leu Met Thr Thr Leu Pro Ser 
705                 710                 715                 720 


Gln Asp Ala Ser Leu Pro Pro Gln Gln Pro Tyr Ile Ala Gly Gln Gln 
                725                 730                 735     


Pro Met Tyr Gln Gln Met Ala Pro Ser Gly Gly Pro Pro Gln Gln Gln 
            740                 745                 750         


Pro Pro Val Ala Gln Gln Pro Gln Ala Gln Gly Pro Pro Ala Gln Gly 
        755                 760                 765             


Ser Glu Ala Gln Leu Ile Ser Phe Asp 
    770                 775         


<210>  3
<211>  4519
<212>  DNA
<213>  Homo sapiens

<400>  3
gctgggcggc caggctccct ggctggccgg tttgggcgtc tgggccgtga aggtgggacc       60

tcctgttccg ggccgcaagt ttccctctcc agccgcccgc cgttcgtagc atgtccccca      120

gaactcgggg agcgcaggca ggacaggctt agagaagacg cggtccccag cgcttgggcc      180

acggacgtcc caccccgctc ctctgtcgct ggagaaccgc cgggccgagc cactgggaga      240

agcaggccag agccttccag ggcctccggc ccgtggaccc gaggaggatg agctggcttt      300

ttcccctgac caagagcgcc tcctcctccg cggctgggtc ccccggtggc ctcaccagcc      360

tccagcagca gaagcagcgc ctgatcgagt ccctccggaa ctcacactcc agtatagccg      420

aaatacagaa agatgtggaa tacagattgc cattcaccat aaacaacctg acaattaaca      480

ttaatatatt gcttcctcca cagtttcctc aggaaaaacc agtgatcagt gtttatccac      540

caatacgaca tcacttaatg gataaacaag gagtgtatgt tacctctcca ttagtaaaca      600

attttacaat gcactcagat cttggaaaaa ttattcagag tctgttggat gagttttgga      660

agaatcctcc agttttagct cctacttcaa cagcatttcc ttatctatac agtaacccaa      720

gtgggatgtc tccttatgct tctcagggtt ttccatttct tcctccatat cctccacaag      780

aagcaaacag gagtatcact tctttatctg ttgctgacac tgtttcttct tcaacaacaa      840

gtcataccac agccaagcct gccgctcctt catttggtgt cctttcaaat ctgccattac      900

ccattcccac agtggatgct tcaataccga caagccaaaa tggttttggg tacaagatgc      960

cagatgtccc tgatgcattt ccagaactct cagaactaag tgtgtcacaa ctcacagata     1020

tgaatgaaca agaggaggta ttactagaac agtttctgac tttgcctcaa ctaaaacaaa     1080

ttattaccga caaagatgac ttagtaaaaa gtattgagga actagcaaga aaaaatctcc     1140

ttttggagcc cagcttggaa gccaaaagac aaactgtttt agataagtat gaattactta     1200

cacagatgaa gtccactttc gaaaagaaga tgcaaaggca gcatgaactt agtgagagct     1260

gtagtgcaag tgcccttcag gcaagattga aagtagctgc acatgaagct gaggaagaat     1320

ctgataatat tgcagaagac ttcttggagg gaaagatgga aatagatgat tttctcagta     1380

gcttcatgga aaagagaaca atttgccact gtagaagagc caaggaagag aaacttcagc     1440

aggcgatagc aatgcacagc caatttcatg ctccactata gattttcctg gaaacatgaa     1500

ctgccaagag aggaatggga cacaaaacca aacactgttt tatatttatg gtttgcaaac     1560

tggcatttca tcagtggcta aattcacaga tatcctatat agattgtata cagaactgag     1620

actgattttg taccgattag aatgattgct atgatctttg agaaattttt ctgcactatt     1680

tgcactgaaa tgtttattta ttgttgataa attgtatcat atttaagttc cactgctgtt     1740

cctcttacct tgattaaatg cctatgcatg tacttttagc tagtttttaa tattttataa     1800

aacttcattt aaatttgtat ttttaacttg aagttccatt tctttatcaa ggatggtatt     1860

tagatttttt tcctcttaac cttttttcaa aaactatttt caactgtgag gaaaccctta     1920

tttttctttc tttgtggata aaactttcaa aagcaattta agatattcat agtgttagga     1980

aacaccaaac ctgcctatgt gccatctcac aaaagaaact tttaatacct acaataaatc     2040

aaaagaataa accagctgtt cttatatatt gtttcatttt taaaactaaa gatgcattta     2100

agaagcaata caagtaaata ttttacctaa taggaaaaaa aaaagttgcc tttcatttaa     2160

accattccaa cagaaattct tatgctaatt taaaacatat atatatctgg taggtttgtg     2220

gttggatagg ttttctaaat tcctaatgtt aaaaacaatc tttatgttaa tatacactaa     2280

atctatacac aaaaaaagtc agtgaacttt tctgaccttt actgtgagtt accttttcct     2340

aagaggaaag ctatagtaat aagtaaaatt taatttttag gcaatcctga tttttaatga     2400

atttaattga gtgttcttgt atactacatt gagcagtttg cttctatacc gtgtcacaaa     2460

attcatgtat ttcttgagaa gccctaaaag ctcataaagg aaaatgccgt gaactatgta     2520

gctcaggctt ggtaaggtgc catctaaatt acaaaacaaa ctaatgcata attttgctta     2580

aatttcatcc cagtatgatt gtcttcccaa caccagcata tagtatagat tgtctgtctt     2640

ttttatattt tttagttctt cctgtacatg tttttggcaa taaagttata ggaagaacaa     2700

aattattttg ttagaattaa aacatgctta atatttagtc tgtttgtgga gggcaggtat     2760

tcacgtggac tgagatacaa tgttggatac agaaaataac tttcattgtc ttcctgacac     2820

tgtgctaagg acatgctgtt aaagcttcaa agtgaccaga tgaggaagga ataattaatt     2880

attactcctg atttgtagat aactgaggta agagtgtttc aaatttatga tagtcttttg     2940

ggtattcaga aacctttcct tatactgcac tggccaccag agcttaattt tcccagcagt     3000

tacagcaatg ggagatagaa cagtctcaat cttttgccaa ccatcaggtt cctagaaacc     3060

aggtaggtgt atcccataac aagggaggag cataccacag cccctcattt gattaattca     3120

tttgatctat ctatgttatt aagtacctac taggaataag gcattgtgga aatactatac     3180

aaagataaac attgtttaga tgcttatcta ctttcctttt caccagaaaa acagaaaaaa     3240

aagaaacatt ttcttacaga gtaaaaatgt tctacataat cacatgagta gttcatctca     3300

gtgtttttta ttctttaaag ttgaactatc ccagtttcat tctataccat tcattggata     3360

accttgttac aacccagtca tgaaacagag cagtgtgatc agttatctgc atttaacaaa     3420

tagacaaatc agtttacata aaggttatgt atgtcaccca cgatgaaaag aatctgcatt     3480

tgaatatgcc cgtatgaatg tgggttctgt ttttgcaaca gagattaagt gaccattttt     3540

tctaatttta tggctatata ttttcttcat aaaaattggt cacatcggag aagcagtgcc     3600

acaggaaaaa tgaaatgcat gtgaaagttt gtattctgat tttacaagat gagatagaaa     3660

tcagaattaa agaggaatac ttaggagtta ctaggctaat cagtgtacga atttgtcata     3720

ggtagagatt taaaggttaa tatcttaaaa tagaagaaaa ttctaaatca atcaatcagt     3780

gagatataaa ctaaacagac ccacttcaaa gttgaaagaa atttctaggc ataaattgag     3840

actaggaaat ttatatcaga atagagggtg cttgacacat atatatgctt aaattgaagg     3900

acagctcaga ttcattttta ggagaagaaa gtaaactaat gtgctcttaa agaataaaaa     3960

tttattctat ggtttctgtc tctgatcatc accttccatt ctataaaaag ctcagttact     4020

gatttgctgg gtcatggtca aaattcttac ctatttattt catatcaact ttaaaaaata     4080

aattacttgc attctatata ttactaattg ggaagtaata tgcctcaaat cagttttata     4140

ctggattatt ccctatgctt taaaccactg ctctcaataa aacacttcct gattaatgtt     4200

tgattattag atattttagt cttgttgggg atattttagt cttgttgggt tagccatgct     4260

ctgaagaatc tgtgaaagta cagtaaagtt ttaataagca ataaatgtaa ccttttatat     4320

aaatctcagt gctaggttaa cttctaataa gcagacgaac atgttacata aattataatg     4380

tctgtcttgt aaaaaagttg aggggactaa aagtttatga ctctgatatg gaagttgtca     4440

tattaaaaaa ctacatttta aaacatcaaa tatttatact atttgctttt caaataaaag     4500

catagtgctg tttggcata                                                  4519


<210>  4
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Trp Leu Phe Pro Leu Thr Lys Ser Ala Ser Ser Ser Ala Ala 
1               5                   10                  15      


Gly Ser Pro Gly Gly Leu Thr Ser Leu Gln Gln Gln Lys Gln Arg Leu 
            20                  25                  30          


Ile Glu Ser Leu Arg Asn Ser His Ser Ser Ile Ala Glu Ile Gln Lys 
        35                  40                  45              


Asp Val Glu Tyr Arg Leu Pro Phe Thr Ile Asn Asn Leu Thr Ile Asn 
    50                  55                  60                  


Ile Asn Ile Leu Leu Pro Pro Gln Phe Pro Gln Glu Lys Pro Val Ile 
65                  70                  75                  80  


Ser Val Tyr Pro Pro Ile Arg His His Leu Met Asp Lys Gln Gly Val 
                85                  90                  95      


Tyr Val Thr Ser Pro Leu Val Asn Asn Phe Thr Met His Ser Asp Leu 
            100                 105                 110         


Gly Lys Ile Ile Gln Ser Leu Leu Asp Glu Phe Trp Lys Asn Pro Pro 
        115                 120                 125             


Val Leu Ala Pro Thr Ser Thr Ala Phe Pro Tyr Leu Tyr Ser Asn Pro 
    130                 135                 140                 


Ser Gly Met Ser Pro Tyr Ala Ser Gln Gly Phe Pro Phe Leu Pro Pro 
145                 150                 155                 160 


Tyr Pro Pro Gln Glu Ala Asn Arg Ser Ile Thr Ser Leu Ser Val Ala 
                165                 170                 175     


Asp Thr Val Ser Ser Ser Thr Thr Ser His Thr Thr Ala Lys Pro Ala 
            180                 185                 190         


Ala Pro Ser Phe Gly Val Leu Ser Asn Leu Pro Leu Pro Ile Pro Thr 
        195                 200                 205             


Val Asp Ala Ser Ile Pro Thr Ser Gln Asn Gly Phe Gly Tyr Lys Met 
    210                 215                 220                 


Pro Asp Val Pro Asp Ala Phe Pro Glu Leu Ser Glu Leu Ser Val Ser 
225                 230                 235                 240 


Gln Leu Thr Asp Met Asn Glu Gln Glu Glu Val Leu Leu Glu Gln Phe 
                245                 250                 255     


Leu Thr Leu Pro Gln Leu Lys Gln Ile Ile Thr Asp Lys Asp Asp Leu 
            260                 265                 270         


Val Lys Ser Ile Glu Glu Leu Ala Arg Lys Asn Leu Leu Leu Glu Pro 
        275                 280                 285             


Ser Leu Glu Ala Lys Arg Gln Thr Val Leu Asp Lys Tyr Glu Leu Leu 
    290                 295                 300                 


Thr Gln Met Lys Ser Thr Phe Glu Lys Lys Met Gln Arg Gln His Glu 
305                 310                 315                 320 


Leu Ser Glu Ser Cys Ser Ala Ser Ala Leu Gln Ala Arg Leu Lys Val 
                325                 330                 335     


Ala Ala His Glu Ala Glu Glu Glu Ser Asp Asn Ile Ala Glu Asp Phe 
            340                 345                 350         


Leu Glu Gly Lys Met Glu Ile Asp Asp Phe Leu Ser Ser Phe Met Glu 
        355                 360                 365             


Lys Arg Thr Ile Cys His Cys Arg Arg Ala Lys Glu Glu Lys Leu Gln 
    370                 375                 380                 


Gln Ala Ile Ala Met His Ser Gln Phe His Ala Pro Leu 
385                 390                 395         


<210>  5
<211>  7769
<212>  DNA
<213>  Homo sapiens

<400>  5
agagcgcgct cgctcaaagc ctgagcgaag atggcggcct ccagagtgaa actctgagag       60

gcagagggag gaggcggagg gggcggggag gcagcgccgc ggcggcacca ggaacccgcg      120

gcagcggagc tgcagggccc cggcggggga aaggggaagt ggtgagggtg aggaggccgg      180

agggcgcctc atcccactct ggaagctgag ccggcggcgg gaggagctag ggctggagcc      240

tctccagcct cccgcgaagg tttgagcaca aaatgaacat aattagggaa aataaggatc      300

tggcatgttt ctacacaaca aaacattcat ggagggggaa gtataagcgt gtcttttcag      360

ttggaactca tgcgattact acatataatc ccaatacctt agaagtaaca aatcagtggc      420

cttatggaga catttgcagc atcagccctg ttggaaaagg acaaggaacg gagttcaacc      480

tcacatttcg taaaggcagt ggaaaaaagt cagaaacttt aaaattttct acagagcaca      540

gaacagaact tcttacagaa gcattgagat ttagaactga tttttcagag ggaaaaatca      600

caggaaggag atacaactgc tataagcatc actggagtga ctcaagaaaa cctgtaattt      660

tggaagtaac tccaggaggc tttgaccaaa ttaatcctgc aaccaacaga gtactctgtt      720

cctatgacta tagaaatatt gaaggatttg tagatctctc agattatcaa ggaggatttt      780

gtatacttta tggaggattt agtagattgc atttatttgc gtcagagcaa agagaagaga      840

ttattaaaag tgcaatagac catgctggta actacatagg tatttcattg cggatcagga      900

aagagccttt agaattcgag caatatttga atcttcgctt tggaaaatac agcactgatg      960

aatccatcac atctttagca gagtttgtag tccaaaaaat atcacctaga cattcggagc     1020

ctgttaaaag agttctagca cttacagaaa catgtttagt agaacgtgat ccggcaacct     1080

ataatattgc aacattgaag cctttaggag aagtatttgc gttggtctgt gactcagaaa     1140

atccacaact ttttaccatt gaatttataa aagggcaagt acggaaatat tcttcaacag     1200

agagagattc cttattagca agtttgctgg atggagtaag agcctctggt aatagagatg     1260

tttgtgtaaa aatgacacca acccataaag gtcagcgatg ggggttactc agcatgcctg     1320

ttgatgagga agtagagagc cttcacctca ggttcttagc tacgcctcca aatggcaact     1380

ttgcagatgc tgtattcagg ttcaatgcta atatttcata cagtggagtc ctacatgcag     1440

taacacaaga tggtctcttc tcagaaaaca aagaaaaact gatcaataat gccataacag     1500

cattactgtc ccaagaaggg gatgtcgttg cttcaaatgc ggaacttgag agtcagttcc     1560

aggctgtgag gaggcttgtg gcatccaaag ctggtttcct ggctttcact cagcttccaa     1620

agtttcgcga gcgtctaggg gtgaaggtag taaaagcact caaaagaagc aacaacggaa     1680

taatccatgc agcagttgat atgctttgtg cccttatgtg tcccatgcat gatgactatg     1740

acttaagaca agaacagttg aacaaagctt ctcttctctc gtcaaagaag tttctggaaa     1800

acttactgga gaaatttaat tcccatgtgg atcatgggac tggtgcccta gttattagtt     1860

cgctcttgga cttccttacc tttgccctct gtgctccata tagtgagaca actgaagggc     1920

agcagtttga tatgctcttg gagatggtag catccaatgg aagaaccctt tttaaacttt     1980

ttcagcatcc ttccatggca ataataaaag gagctgggtt ggttatgaag gcaataatag     2040

aggaaggtga taaagaaatt gctacaaaaa tgcaggagct tgccctaagt gaaggtgcct     2100

tacctcgaca cttgcatact gcgatgttta caataagctc agatcaaagg atgcttacaa     2160

atagacagct aagtagacat ttagtgggac tctggacagc tgataatgca actgcaacaa     2220

acttgttgaa acgcattttg ccgccaggct tgctggcata cttggaaagc tcagatctcg     2280

tacctgagaa ggatgctgat cggatgcatg ttagagacaa tgtgaaaata gcaatggatc     2340

agtatggaaa atttaataaa gttccagagt ggcaaagact agctggaaaa gctgctaaag     2400

aagttgaaaa atttgccaaa gaaaaagtgg atcttgtatt gatgcactgg agggatagga     2460

tgggcattgc tcaaaaagag gacaaaaaca atatgaatat aaatcagaag ccagtggttc     2520

ttcgaaagag aagacaaaga ataaaaatag aagcaaattg ggatctcttc tattataggt     2580

ttggtcaaga ccatgccagg tcaaacctta tttggaattt caaaacacga gaagaactga     2640

aagatactct tgaatctgaa atgagagcat ttaatattga cagagaactt ggaagtgcaa     2700

atgtgatctc ctggaaccac catgagtttg aggttaaata tgagtgcctg gcagaggaaa     2760

ttaaaatagg agactattac ctgagattac tattggagga agatgagaat gaagaaagtg     2820

gatcaattaa gagatcgtat gaatttttca atgagcttta tcatcgcttc ttgctcaccc     2880

caaaagtaaa catgaagtgt ttatgtttac aagcccttgc tattgtttat ggcagatgtc     2940

acgaagaaat aggacctttt acagatacca gatatatcat tggaatgtta gagaggtgca     3000

cagataaact tgaacgagat aggttgattc tcttccttaa caagttgatc cttaataaga     3060

aaaatgttaa ggatctcatg gattcaaatg gaataagaat ccttgtggac ttgcttaccc     3120

ttgcacatct ccatgtaagc cgagctacag taccactgca aagcaatgta attgaagctg     3180

ctccagatat gaaaagagag agtgaaaagg aatggtattt tggcaacgca gacaaagaaa     3240

ggagtggccc gtatggattt catgagatgc aagaattgtg gaccaaagga atgttaaatg     3300

caaaaaccag atgctgggct caaggcatgg atggatggcg accacttcag tccatacccc     3360

agcttaagtg gtgtctctta gccagtggac aggctgtcct gaatgaaact gaccttgcta     3420

cccttatatt gaacatgttg atcacaatgt gtggatattt tccaagcagg gatcaagaca     3480

atgccatcat tcggcctcta cccaaagtga aaagactgct gtcagatagc acttgccttc     3540

cccatattat tcagctactg ctgacctttg accctatcct tgttgagaag gttgctattt     3600

tgttatacca tatcatgcaa gataacccac agttaccccg cctttatctg agtggagtat     3660

ttttctttat catgatgtac acaggttcca atgtgcttcc tgttgctcga tttttgaaat     3720

acacacatac caaacaggct ttcaagtcag aagagacaaa aggacaagat atttttcaga     3780

gaagtatact tgggcacatt ctacctgaag caatggtttg ttacttagaa aattatgaac     3840

ctgaaaagtt ttctgagatt tttctaggag aatttgatac tccagaagca atctggagca     3900

gtgaaatgag gcgcctgatg atagagaaga ttgctgccca tctcgcggat ttcacacctc     3960

gtcttcagag taacacaaga gcactttatc agtattgccc cattcctata atcaactatc     4020

cacaactcga aaatgaacta ttttgtaata tttattacct caaacaactg tgtgatacac     4080

tccggtttcc agattggcca attaaagacc cggttaagct tctaaaagat acccttgatg     4140

cctggaagaa agaagtagaa aagaagccac ctatgatgtc aatagatgat gcttatgaag     4200

tgcttaatct gcctcaagga cagggaccgc atgatgagag caagattagg aaagcttact     4260

tcagacttgc acaaaagtac caccctgata agaatccaga agggagggac atgtttgaaa     4320

aagtaaataa agcatatgaa tttttatgta ccaaatcagc aaaaatagtg gatgggccag     4380

atccagagaa tataatttta attctaaaaa cacagagcat cctcttcaac cgtcataaag     4440

aagatttaca gccttataaa tatgcaggat accccatgct tattcggact ataacaatgg     4500

aaacttcaga tgacctcctt ttctcaaaag aatcaccatt gttgcctgcg gctacagagc     4560

tagctttcca tactgtcaac tgttcagccc tcaatgctga agagctcaga agagagaatg     4620

gactagaggt gttacaagag gcatttagtc gctgtgtggc tgtcttgact cgtgctagta     4680

aaccaagtga catgtcagta caggtgtgtg gatacataag taaatgctac agtgtggctg     4740

ctcagtttga ggaatgccga gagaagatca cggaaatgcc tagcatcatc aaggatctct     4800

gtcgggtact atattttggc aagagtattc cccgcgtagc tgctcttggg gtagaatgtg     4860

tcagttcttt tgctgtggat ttctggctac agacacacct atttcaggct ggaattttgt     4920

ggtatctcct tggttttctg tttaattatg actacacact agaagagagt ggcattcaga     4980

aaagtgaaga aacaaaccag caggaggtag caaacagcct tgccaaactg agtgtccatg     5040

ctctgagtcg ccttggaggg tatttggctg aagaacaagc aactccagaa aatccaacca     5100

taaggaaaag cttagctggc atgctgacac cctatgttgc tagaaaactt gctgtggcta     5160

gtgtgactga gattttgaag atgcttaaca gcaacacaga aagtccatat ttgatatgga     5220

acaattctac aagagcagaa ttacttgaat ttcttgaatc ccaacaagaa aacatgatta     5280

aaaaaggtga ttgtgacaaa acttatggat cagaatttgt ctacagtgat catgccaaag     5340

aacttattgt aggggagatt tttgttaggg tgtataatga agttcctact ttccaactgg     5400

aggttccaaa agcatttgct gcaagtctct tggattatat aggctcgcag gcccaatact     5460

tgcacacatt catggccatc acacacgcgg caaaagtgga gtcagagcaa catggagatc     5520

gcttaccgag agtagaaatg gctttggagg ctctgagaaa tgtcataaaa tacaatccag     5580

gttctgagag tgaatgcatt gggcacttta agttgatatt ttctcttctc cgagttcatg     5640

gagctggtca agtgcagcag ttggctttag aggttgtgaa tatagtgaca tctaaccaag     5700

actgtgtcaa caatattgct gaatcaatgg ttttgtccag tttattggct cttctacatt     5760

cattgccatc aagtcgtcag cttgttctgg aaactcttta tgctttgaca tcgagtacaa     5820

aaataatcaa agaagcaatg gcaaagggtg ctttgatcta tttactggat atgttctgca     5880

attcaacaca tccacaggtt cgagcccaaa cagcagaact ttttgccaaa atgacagcag     5940

ataaactgat aggtccaaag gttcgaatta cgttaatgaa atttctacca agcgttttca     6000

tggatgctat gagagacaat cctgaagctg ctgtacatat ttttgaagga actcatgaaa     6060

atcctgagtt aatttggaat gataattcca gagataaagt gtccacaaca gttagggaaa     6120

tgatgctaga gcactttaaa aatcagcagg acaaccctga ggcaaactgg aagttgcctg     6180

aagattttgc tgtggtgttt ggagaagcag agggtgaact tgctgttgga ggagtcttct     6240

tgaggatctt tattgcacaa ccagcctggg ttctaagaaa gcctagagaa tttcttattg     6300

ccctgttaga aaaattaact gagctcctag agaagaacaa tcctcatgga gaaactctgg     6360

aaaccttgac aatggcaaca gtgtgtctct tcagcgcaca acctcagctg gcagatcagg     6420

tcccgccatt gggccatctt cccaaagtta tccaggcaat gaatcatagg aacaatgcca     6480

ttcctaagag tgccattcgg gttatccatg ccttgtctga aaatgagctg tgtgttcgag     6540

ccatggcatc tttagagacc attggcccac tgatgaatgg aatgaaaaag cgagcagata     6600

ctgttggtct agcctgtgaa gcaattaatc gaatgtttca gaaggagcag agtgaattag     6660

tagcacaagc cctgaaagca gatttggttc catacctctt aaaattactc gaaggcattg     6720

gccttgaaaa cctggacagc ccagcagcca ctaaggctca gattgttaaa gctctcaagg     6780

caatgactcg aagtttgcag tatggagaac aggtgaatga aatcctgtgc cgttcttcag     6840

tctggagtgc cttcaaagat cagaaacatg atttgttcat ttctgagtca caaacagcag     6900

gatacctcac aggacctgga gttgctggct accttaccgc aggtacatct acatcagtca     6960

tgtctaacct gccacctcct gtagaccatg aggcaggcga ccttggctat cagacttgaa     7020

atattcacga gagacaataa acgctgaaag gccagtgcca agtccacatt cctccagctg     7080

atacgttgaa gcaaactctt actgcctttc tcctggtttc atgacagtgt tattcctttt     7140

tctataaata tatttttagg aaaaaaagtc agtgatccta attgtatcac attataagaa     7200

agcactctgt ggatcaacat aagtgggtac acaagaattt tttttttctt ggtgtatgta     7260

agcacatttg ttcctttata tctgtttaca aaactgtgaa tcaaaaagac aaaactttct     7320

tcctagtttt tgtaattttt tttttgaact agcatgactg tagggttgag ctacagtcaa     7380

caaaaattgg gctaagtcac ttttccccag gaaagaatat ttccctctcc tgcatcaagt     7440

ctgcgtggcc atcctccccc caccatccaa gactattagg ttttgtccct gcacccttca     7500

ctggcatcct caatcattaa ccttctgaaa gctcacagta cacattagta tgtataactg     7560

gctttaccaa attgaatgaa aaggagcttg tgcaaaaaaa tttaaaaatg gatgtcaaga     7620

tgttatgtaa aagatgagtg taattgtgaa atgttctata cactatcaaa tatataaagc     7680

tttctatatt gaatgtacat tatacagatc attcatatgt gtacataaaa ttttaaaaat     7740

aaagggaatt gactgctttg ttaatgaga                                       7769


<210>  6
<211>  2248
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asn Ile Ile Arg Glu Asn Lys Asp Leu Ala Cys Phe Tyr Thr Thr 
1               5                   10                  15      


Lys His Ser Trp Arg Gly Lys Tyr Lys Arg Val Phe Ser Val Gly Thr 
            20                  25                  30          


His Ala Ile Thr Thr Tyr Asn Pro Asn Thr Leu Glu Val Thr Asn Gln 
        35                  40                  45              


Trp Pro Tyr Gly Asp Ile Cys Ser Ile Ser Pro Val Gly Lys Gly Gln 
    50                  55                  60                  


Gly Thr Glu Phe Asn Leu Thr Phe Arg Lys Gly Ser Gly Lys Lys Ser 
65                  70                  75                  80  


Glu Thr Leu Lys Phe Ser Thr Glu His Arg Thr Glu Leu Leu Thr Glu 
                85                  90                  95      


Ala Leu Arg Phe Arg Thr Asp Phe Ser Glu Gly Lys Ile Thr Gly Arg 
            100                 105                 110         


Arg Tyr Asn Cys Tyr Lys His His Trp Ser Asp Ser Arg Lys Pro Val 
        115                 120                 125             


Ile Leu Glu Val Thr Pro Gly Gly Phe Asp Gln Ile Asn Pro Ala Thr 
    130                 135                 140                 


Asn Arg Val Leu Cys Ser Tyr Asp Tyr Arg Asn Ile Glu Gly Phe Val 
145                 150                 155                 160 


Asp Leu Ser Asp Tyr Gln Gly Gly Phe Cys Ile Leu Tyr Gly Gly Phe 
                165                 170                 175     


Ser Arg Leu His Leu Phe Ala Ser Glu Gln Arg Glu Glu Ile Ile Lys 
            180                 185                 190         


Ser Ala Ile Asp His Ala Gly Asn Tyr Ile Gly Ile Ser Leu Arg Ile 
        195                 200                 205             


Arg Lys Glu Pro Leu Glu Phe Glu Gln Tyr Leu Asn Leu Arg Phe Gly 
    210                 215                 220                 


Lys Tyr Ser Thr Asp Glu Ser Ile Thr Ser Leu Ala Glu Phe Val Val 
225                 230                 235                 240 


Gln Lys Ile Ser Pro Arg His Ser Glu Pro Val Lys Arg Val Leu Ala 
                245                 250                 255     


Leu Thr Glu Thr Cys Leu Val Glu Arg Asp Pro Ala Thr Tyr Asn Ile 
            260                 265                 270         


Ala Thr Leu Lys Pro Leu Gly Glu Val Phe Ala Leu Val Cys Asp Ser 
        275                 280                 285             


Glu Asn Pro Gln Leu Phe Thr Ile Glu Phe Ile Lys Gly Gln Val Arg 
    290                 295                 300                 


Lys Tyr Ser Ser Thr Glu Arg Asp Ser Leu Leu Ala Ser Leu Leu Asp 
305                 310                 315                 320 


Gly Val Arg Ala Ser Gly Asn Arg Asp Val Cys Val Lys Met Thr Pro 
                325                 330                 335     


Thr His Lys Gly Gln Arg Trp Gly Leu Leu Ser Met Pro Val Asp Glu 
            340                 345                 350         


Glu Val Glu Ser Leu His Leu Arg Phe Leu Ala Thr Pro Pro Asn Gly 
        355                 360                 365             


Asn Phe Ala Asp Ala Val Phe Arg Phe Asn Ala Asn Ile Ser Tyr Ser 
    370                 375                 380                 


Gly Val Leu His Ala Val Thr Gln Asp Gly Leu Phe Ser Glu Asn Lys 
385                 390                 395                 400 


Glu Lys Leu Ile Asn Asn Ala Ile Thr Ala Leu Leu Ser Gln Glu Gly 
                405                 410                 415     


Asp Val Val Ala Ser Asn Ala Glu Leu Glu Ser Gln Phe Gln Ala Val 
            420                 425                 430         


Arg Arg Leu Val Ala Ser Lys Ala Gly Phe Leu Ala Phe Thr Gln Leu 
        435                 440                 445             


Pro Lys Phe Arg Glu Arg Leu Gly Val Lys Val Val Lys Ala Leu Lys 
    450                 455                 460                 


Arg Ser Asn Asn Gly Ile Ile His Ala Ala Val Asp Met Leu Cys Ala 
465                 470                 475                 480 


Leu Met Cys Pro Met His Asp Asp Tyr Asp Leu Arg Gln Glu Gln Leu 
                485                 490                 495     


Asn Lys Ala Ser Leu Leu Ser Ser Lys Lys Phe Leu Glu Asn Leu Leu 
            500                 505                 510         


Glu Lys Phe Asn Ser His Val Asp His Gly Thr Gly Ala Leu Val Ile 
        515                 520                 525             


Ser Ser Leu Leu Asp Phe Leu Thr Phe Ala Leu Cys Ala Pro Tyr Ser 
    530                 535                 540                 


Glu Thr Thr Glu Gly Gln Gln Phe Asp Met Leu Leu Glu Met Val Ala 
545                 550                 555                 560 


Ser Asn Gly Arg Thr Leu Phe Lys Leu Phe Gln His Pro Ser Met Ala 
                565                 570                 575     


Ile Ile Lys Gly Ala Gly Leu Val Met Lys Ala Ile Ile Glu Glu Gly 
            580                 585                 590         


Asp Lys Glu Ile Ala Thr Lys Met Gln Glu Leu Ala Leu Ser Glu Gly 
        595                 600                 605             


Ala Leu Pro Arg His Leu His Thr Ala Met Phe Thr Ile Ser Ser Asp 
    610                 615                 620                 


Gln Arg Met Leu Thr Asn Arg Gln Leu Ser Arg His Leu Val Gly Leu 
625                 630                 635                 640 


Trp Thr Ala Asp Asn Ala Thr Ala Thr Asn Leu Leu Lys Arg Ile Leu 
                645                 650                 655     


Pro Pro Gly Leu Leu Ala Tyr Leu Glu Ser Ser Asp Leu Val Pro Glu 
            660                 665                 670         


Lys Asp Ala Asp Arg Met His Val Arg Asp Asn Val Lys Ile Ala Met 
        675                 680                 685             


Asp Gln Tyr Gly Lys Phe Asn Lys Val Pro Glu Trp Gln Arg Leu Ala 
    690                 695                 700                 


Gly Lys Ala Ala Lys Glu Val Glu Lys Phe Ala Lys Glu Lys Val Asp 
705                 710                 715                 720 


Leu Val Leu Met His Trp Arg Asp Arg Met Gly Ile Ala Gln Lys Glu 
                725                 730                 735     


Asp Lys Asn Asn Met Asn Ile Asn Gln Lys Pro Val Val Leu Arg Lys 
            740                 745                 750         


Arg Arg Gln Arg Ile Lys Ile Glu Ala Asn Trp Asp Leu Phe Tyr Tyr 
        755                 760                 765             


Arg Phe Gly Gln Asp His Ala Arg Ser Asn Leu Ile Trp Asn Phe Lys 
    770                 775                 780                 


Thr Arg Glu Glu Leu Lys Asp Thr Leu Glu Ser Glu Met Arg Ala Phe 
785                 790                 795                 800 


Asn Ile Asp Arg Glu Leu Gly Ser Ala Asn Val Ile Ser Trp Asn His 
                805                 810                 815     


His Glu Phe Glu Val Lys Tyr Glu Cys Leu Ala Glu Glu Ile Lys Ile 
            820                 825                 830         


Gly Asp Tyr Tyr Leu Arg Leu Leu Leu Glu Glu Asp Glu Asn Glu Glu 
        835                 840                 845             


Ser Gly Ser Ile Lys Arg Ser Tyr Glu Phe Phe Asn Glu Leu Tyr His 
    850                 855                 860                 


Arg Phe Leu Leu Thr Pro Lys Val Asn Met Lys Cys Leu Cys Leu Gln 
865                 870                 875                 880 


Ala Leu Ala Ile Val Tyr Gly Arg Cys His Glu Glu Ile Gly Pro Phe 
                885                 890                 895     


Thr Asp Thr Arg Tyr Ile Ile Gly Met Leu Glu Arg Cys Thr Asp Lys 
            900                 905                 910         


Leu Glu Arg Asp Arg Leu Ile Leu Phe Leu Asn Lys Leu Ile Leu Asn 
        915                 920                 925             


Lys Lys Asn Val Lys Asp Leu Met Asp Ser Asn Gly Ile Arg Ile Leu 
    930                 935                 940                 


Val Asp Leu Leu Thr Leu Ala His Leu His Val Ser Arg Ala Thr Val 
945                 950                 955                 960 


Pro Leu Gln Ser Asn Val Ile Glu Ala Ala Pro Asp Met Lys Arg Glu 
                965                 970                 975     


Ser Glu Lys Glu Trp Tyr Phe Gly Asn Ala Asp Lys Glu Arg Ser Gly 
            980                 985                 990         


Pro Tyr Gly Phe His Glu Met Gln  Glu Leu Trp Thr Lys  Gly Met Leu 
        995                 1000                 1005             


Asn Ala  Lys Thr Arg Cys Trp  Ala Gln Gly Met Asp  Gly Trp Arg 
    1010                 1015                 1020             


Pro Leu  Gln Ser Ile Pro Gln  Leu Lys Trp Cys Leu  Leu Ala Ser 
    1025                 1030                 1035             


Gly Gln  Ala Val Leu Asn Glu  Thr Asp Leu Ala Thr  Leu Ile Leu 
    1040                 1045                 1050             


Asn Met  Leu Ile Thr Met Cys  Gly Tyr Phe Pro Ser  Arg Asp Gln 
    1055                 1060                 1065             


Asp Asn  Ala Ile Ile Arg Pro  Leu Pro Lys Val Lys  Arg Leu Leu 
    1070                 1075                 1080             


Ser Asp  Ser Thr Cys Leu Pro  His Ile Ile Gln Leu  Leu Leu Thr 
    1085                 1090                 1095             


Phe Asp  Pro Ile Leu Val Glu  Lys Val Ala Ile Leu  Leu Tyr His 
    1100                 1105                 1110             


Ile Met  Gln Asp Asn Pro Gln  Leu Pro Arg Leu Tyr  Leu Ser Gly 
    1115                 1120                 1125             


Val Phe  Phe Phe Ile Met Met  Tyr Thr Gly Ser Asn  Val Leu Pro 
    1130                 1135                 1140             


Val Ala  Arg Phe Leu Lys Tyr  Thr His Thr Lys Gln  Ala Phe Lys 
    1145                 1150                 1155             


Ser Glu  Glu Thr Lys Gly Gln  Asp Ile Phe Gln Arg  Ser Ile Leu 
    1160                 1165                 1170             


Gly His  Ile Leu Pro Glu Ala  Met Val Cys Tyr Leu  Glu Asn Tyr 
    1175                 1180                 1185             


Glu Pro  Glu Lys Phe Ser Glu  Ile Phe Leu Gly Glu  Phe Asp Thr 
    1190                 1195                 1200             


Pro Glu  Ala Ile Trp Ser Ser  Glu Met Arg Arg Leu  Met Ile Glu 
    1205                 1210                 1215             


Lys Ile  Ala Ala His Leu Ala  Asp Phe Thr Pro Arg  Leu Gln Ser 
    1220                 1225                 1230             


Asn Thr  Arg Ala Leu Tyr Gln  Tyr Cys Pro Ile Pro  Ile Ile Asn 
    1235                 1240                 1245             


Tyr Pro  Gln Leu Glu Asn Glu  Leu Phe Cys Asn Ile  Tyr Tyr Leu 
    1250                 1255                 1260             


Lys Gln  Leu Cys Asp Thr Leu  Arg Phe Pro Asp Trp  Pro Ile Lys 
    1265                 1270                 1275             


Asp Pro  Val Lys Leu Leu Lys  Asp Thr Leu Asp Ala  Trp Lys Lys 
    1280                 1285                 1290             


Glu Val  Glu Lys Lys Pro Pro  Met Met Ser Ile Asp  Asp Ala Tyr 
    1295                 1300                 1305             


Glu Val  Leu Asn Leu Pro Gln  Gly Gln Gly Pro His  Asp Glu Ser 
    1310                 1315                 1320             


Lys Ile  Arg Lys Ala Tyr Phe  Arg Leu Ala Gln Lys  Tyr His Pro 
    1325                 1330                 1335             


Asp Lys  Asn Pro Glu Gly Arg  Asp Met Phe Glu Lys  Val Asn Lys 
    1340                 1345                 1350             


Ala Tyr  Glu Phe Leu Cys Thr  Lys Ser Ala Lys Ile  Val Asp Gly 
    1355                 1360                 1365             


Pro Asp  Pro Glu Asn Ile Ile  Leu Ile Leu Lys Thr  Gln Ser Ile 
    1370                 1375                 1380             


Leu Phe  Asn Arg His Lys Glu  Asp Leu Gln Pro Tyr  Lys Tyr Ala 
    1385                 1390                 1395             


Gly Tyr  Pro Met Leu Ile Arg  Thr Ile Thr Met Glu  Thr Ser Asp 
    1400                 1405                 1410             


Asp Leu  Leu Phe Ser Lys Glu  Ser Pro Leu Leu Pro  Ala Ala Thr 
    1415                 1420                 1425             


Glu Leu  Ala Phe His Thr Val  Asn Cys Ser Ala Leu  Asn Ala Glu 
    1430                 1435                 1440             


Glu Leu  Arg Arg Glu Asn Gly  Leu Glu Val Leu Gln  Glu Ala Phe 
    1445                 1450                 1455             


Ser Arg  Cys Val Ala Val Leu  Thr Arg Ala Ser Lys  Pro Ser Asp 
    1460                 1465                 1470             


Met Ser  Val Gln Val Cys Gly  Tyr Ile Ser Lys Cys  Tyr Ser Val 
    1475                 1480                 1485             


Ala Ala  Gln Phe Glu Glu Cys  Arg Glu Lys Ile Thr  Glu Met Pro 
    1490                 1495                 1500             


Ser Ile  Ile Lys Asp Leu Cys  Arg Val Leu Tyr Phe  Gly Lys Ser 
    1505                 1510                 1515             


Ile Pro  Arg Val Ala Ala Leu  Gly Val Glu Cys Val  Ser Ser Phe 
    1520                 1525                 1530             


Ala Val  Asp Phe Trp Leu Gln  Thr His Leu Phe Gln  Ala Gly Ile 
    1535                 1540                 1545             


Leu Trp  Tyr Leu Leu Gly Phe  Leu Phe Asn Tyr Asp  Tyr Thr Leu 
    1550                 1555                 1560             


Glu Glu  Ser Gly Ile Gln Lys  Ser Glu Glu Thr Asn  Gln Gln Glu 
    1565                 1570                 1575             


Val Ala  Asn Ser Leu Ala Lys  Leu Ser Val His Ala  Leu Ser Arg 
    1580                 1585                 1590             


Leu Gly  Gly Tyr Leu Ala Glu  Glu Gln Ala Thr Pro  Glu Asn Pro 
    1595                 1600                 1605             


Thr Ile  Arg Lys Ser Leu Ala  Gly Met Leu Thr Pro  Tyr Val Ala 
    1610                 1615                 1620             


Arg Lys  Leu Ala Val Ala Ser  Val Thr Glu Ile Leu  Lys Met Leu 
    1625                 1630                 1635             


Asn Ser  Asn Thr Glu Ser Pro  Tyr Leu Ile Trp Asn  Asn Ser Thr 
    1640                 1645                 1650             


Arg Ala  Glu Leu Leu Glu Phe  Leu Glu Ser Gln Gln  Glu Asn Met 
    1655                 1660                 1665             


Ile Lys  Lys Gly Asp Cys Asp  Lys Thr Tyr Gly Ser  Glu Phe Val 
    1670                 1675                 1680             


Tyr Ser  Asp His Ala Lys Glu  Leu Ile Val Gly Glu  Ile Phe Val 
    1685                 1690                 1695             


Arg Val  Tyr Asn Glu Val Pro  Thr Phe Gln Leu Glu  Val Pro Lys 
    1700                 1705                 1710             


Ala Phe  Ala Ala Ser Leu Leu  Asp Tyr Ile Gly Ser  Gln Ala Gln 
    1715                 1720                 1725             


Tyr Leu  His Thr Phe Met Ala  Ile Thr His Ala Ala  Lys Val Glu 
    1730                 1735                 1740             


Ser Glu  Gln His Gly Asp Arg  Leu Pro Arg Val Glu  Met Ala Leu 
    1745                 1750                 1755             


Glu Ala  Leu Arg Asn Val Ile  Lys Tyr Asn Pro Gly  Ser Glu Ser 
    1760                 1765                 1770             


Glu Cys  Ile Gly His Phe Lys  Leu Ile Phe Ser Leu  Leu Arg Val 
    1775                 1780                 1785             


His Gly  Ala Gly Gln Val Gln  Gln Leu Ala Leu Glu  Val Val Asn 
    1790                 1795                 1800             


Ile Val  Thr Ser Asn Gln Asp  Cys Val Asn Asn Ile  Ala Glu Ser 
    1805                 1810                 1815             


Met Val  Leu Ser Ser Leu Leu  Ala Leu Leu His Ser  Leu Pro Ser 
    1820                 1825                 1830             


Ser Arg  Gln Leu Val Leu Glu  Thr Leu Tyr Ala Leu  Thr Ser Ser 
    1835                 1840                 1845             


Thr Lys  Ile Ile Lys Glu Ala  Met Ala Lys Gly Ala  Leu Ile Tyr 
    1850                 1855                 1860             


Leu Leu  Asp Met Phe Cys Asn  Ser Thr His Pro Gln  Val Arg Ala 
    1865                 1870                 1875             


Gln Thr  Ala Glu Leu Phe Ala  Lys Met Thr Ala Asp  Lys Leu Ile 
    1880                 1885                 1890             


Gly Pro  Lys Val Arg Ile Thr  Leu Met Lys Phe Leu  Pro Ser Val 
    1895                 1900                 1905             


Phe Met  Asp Ala Met Arg Asp  Asn Pro Glu Ala Ala  Val His Ile 
    1910                 1915                 1920             


Phe Glu  Gly Thr His Glu Asn  Pro Glu Leu Ile Trp  Asn Asp Asn 
    1925                 1930                 1935             


Ser Arg  Asp Lys Val Ser Thr  Thr Val Arg Glu Met  Met Leu Glu 
    1940                 1945                 1950             


His Phe  Lys Asn Gln Gln Asp  Asn Pro Glu Ala Asn  Trp Lys Leu 
    1955                 1960                 1965             


Pro Glu  Asp Phe Ala Val Val  Phe Gly Glu Ala Glu  Gly Glu Leu 
    1970                 1975                 1980             


Ala Val  Gly Gly Val Phe Leu  Arg Ile Phe Ile Ala  Gln Pro Ala 
    1985                 1990                 1995             


Trp Val  Leu Arg Lys Pro Arg  Glu Phe Leu Ile Ala  Leu Leu Glu 
    2000                 2005                 2010             


Lys Leu  Thr Glu Leu Leu Glu  Lys Asn Asn Pro His  Gly Glu Thr 
    2015                 2020                 2025             


Leu Glu  Thr Leu Thr Met Ala  Thr Val Cys Leu Phe  Ser Ala Gln 
    2030                 2035                 2040             


Pro Gln  Leu Ala Asp Gln Val  Pro Pro Leu Gly His  Leu Pro Lys 
    2045                 2050                 2055             


Val Ile  Gln Ala Met Asn His  Arg Asn Asn Ala Ile  Pro Lys Ser 
    2060                 2065                 2070             


Ala Ile  Arg Val Ile His Ala  Leu Ser Glu Asn Glu  Leu Cys Val 
    2075                 2080                 2085             


Arg Ala  Met Ala Ser Leu Glu  Thr Ile Gly Pro Leu  Met Asn Gly 
    2090                 2095                 2100             


Met Lys  Lys Arg Ala Asp Thr  Val Gly Leu Ala Cys  Glu Ala Ile 
    2105                 2110                 2115             


Asn Arg  Met Phe Gln Lys Glu  Gln Ser Glu Leu Val  Ala Gln Ala 
    2120                 2125                 2130             


Leu Lys  Ala Asp Leu Val Pro  Tyr Leu Leu Lys Leu  Leu Glu Gly 
    2135                 2140                 2145             


Ile Gly  Leu Glu Asn Leu Asp  Ser Pro Ala Ala Thr  Lys Ala Gln 
    2150                 2155                 2160             


Ile Val  Lys Ala Leu Lys Ala  Met Thr Arg Ser Leu  Gln Tyr Gly 
    2165                 2170                 2175             


Glu Gln  Val Asn Glu Ile Leu  Cys Arg Ser Ser Val  Trp Ser Ala 
    2180                 2185                 2190             


Phe Lys  Asp Gln Lys His Asp  Leu Phe Ile Ser Glu  Ser Gln Thr 
    2195                 2200                 2205             


Ala Gly  Tyr Leu Thr Gly Pro  Gly Val Ala Gly Tyr  Leu Thr Ala 
    2210                 2215                 2220             


Gly Thr  Ser Thr Ser Val Met  Ser Asn Leu Pro Pro  Pro Val Asp 
    2225                 2230                 2235             


His Glu  Ala Gly Asp Leu Gly  Tyr Gln Thr 
    2240                 2245             


<210>  7

<400>  7
000

<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  8
gtattactga tattggtggg                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  9
gaagatgaca ggaacaaccg                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  10
aagagcccag ggatagctca                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  11
tgaacagtac cgcctgcaga                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  12
tgccacggga tcccaatgcc                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  13
cttggggtac gaagtgtacg                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  14
gcacgcagcc cccaccaacg                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  15
cagcccctca tagtacactg                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  16
cataaggaga catcccactt                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  17
ggtggataaa cactgatcac                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  18
cattacaaca acctgctacg                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  19
atccctccgt acgagaatgg                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  20
tggttctgcc agcaaacgct                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
ctgttgcctt catagataag                                                   20


<210>  22
<211>  377
<212>  PRT
<213>  Nematostella vectensis

<400>  22

Met Arg Arg Ala Glu Glu Asn Asn Gly Phe Gly Thr Ile Pro Lys Arg 
1               5                   10                  15      


Arg Asn Gln His Thr Pro Phe Tyr Ala Ser Ile Gly Met Ile Val Val 
            20                  25                  30          


Ile Ile Val Ala Phe Thr Ser Tyr His Ile Thr Ser Tyr Gly Asp Asp 
        35                  40                  45              


Arg Asn Arg Ala Met Arg Gln Tyr Ser Phe Thr Phe Ser Leu Ala Tyr 
    50                  55                  60                  


Leu Ala Phe Leu Val Gly Glu Leu Leu Arg Arg Cys Cys Leu Phe Ala 
65                  70                  75                  80  


Glu Glu Tyr Arg His Ile Glu Thr Arg Tyr Asn Gly Ser Leu Lys Lys 
                85                  90                  95      


Ala Ile Gln Thr Thr Phe Ser Phe Gly His Asn Asn Val Leu Phe Val 
            100                 105                 110         


Ala Ser Leu Leu Phe Phe Val Val Phe Val Ala Ser Asn Asp Pro Asn 
        115                 120                 125             


Gly Ser Ser Ser Val Ile Gln Gly Asn Ser Thr Ala Glu Pro His Thr 
    130                 135                 140                 


Glu Met Arg Gln Thr Ser Gly Trp Gln Gly Leu Trp Gly Gln Phe Ile 
145                 150                 155                 160 


Ile Ser Ala Leu Leu Thr Pro Leu Val Val His Leu Leu Gly Leu Arg 
                165                 170                 175     


Glu Leu Ser Lys Val Glu Glu Ser Gln Leu Asn Glu Lys Glu Asn Lys 
            180                 185                 190         


Asn Val Ala Asp Gly Leu Ala Trp Ser Tyr Tyr Phe Gly Tyr Leu Lys 
        195                 200                 205             


Phe Val Leu Pro Glu Leu Glu Lys Gln Ile Glu Lys Thr Ser Lys Phe 
    210                 215                 220                 


Arg Ser Lys Glu Lys Phe Val Lys Lys Met Phe Ile Leu Ile Pro Ser 
225                 230                 235                 240 


Asn Cys Phe Trp Asp Asp Lys Ile Pro Gly Ser Asp Tyr Asp Pro Gln 
                245                 250                 255     


Asn Arg Ile Thr Phe Glu Gly Asn Thr Glu Pro Leu Glu Lys Thr Arg 
            260                 265                 270         


Gly Gly Val Phe Leu Arg His Tyr Lys His Ser Val Tyr Glu Ile Lys 
        275                 280                 285             


Asp Gly Glu Asn Glu Pro Trp Phe Cys Ile Met Glu Tyr Ala Thr Pro 
    290                 295                 300                 


Leu Leu Thr Leu Tyr Asp Met Ser Val Ala Gln Pro Gly Glu Leu Ser 
305                 310                 315                 320 


Arg Glu Glu Arg Asp Ala Gln Val Val Val Phe Leu Arg Lys Leu Gln 
                325                 330                 335     


Asp Ile Leu Glu Gly Asp Arg Ala Cys Gln Gly Lys Tyr Glu Leu Val 
            340                 345                 350         


Thr Phe Ser Pro Asp Arg Asp Leu Ala Asp Val Met Leu Arg Lys Leu 
        355                 360                 365             


Lys Asp Ser Glu Leu Glu Ile Gly Gly 
    370                 375         


<210>  23
<211>  398
<212>  PRT
<213>  Unknown

<220>
<223>  sp|E7F4N7|STING DANRE

<400>  23

Met Ser Val Met Gly Glu Asp Ala Leu Val Pro Arg Ala Arg Ser Arg 
1               5                   10                  15      


Leu Pro Val Met Cys Ala Ala Gly Leu Gly Phe Leu Thr Leu Ala Val 
            20                  25                  30          


Ala Trp Leu Leu Asp Ser Asp Lys Phe Ser Glu Arg Ala Gly Ile Ile 
        35                  40                  45              


Ala Phe Gly Leu Met Leu Glu Arg Phe Ile Tyr Cys Ile Cys Leu Leu 
    50                  55                  60                  


Ala Glu Glu Leu Leu Phe His Ser Arg Gln Arg Tyr His Gly Arg Met 
65                  70                  75                  80  


Ser Glu Ile Phe Arg Ala Cys Phe Arg Gly Ser Gly Ile Leu Gly Met 
                85                  90                  95      


Cys Ala Ile Phe Leu Met Leu Met Leu Gly Gly Val Ser Phe Ser Val 
            100                 105                 110         


Lys Gln Trp Ser His Phe Asn Leu Met Cys Ala Gly Tyr Met Leu Leu 
        115                 120                 125             


Asn Ser Leu Gly Val Leu Gly Pro Ala Pro Val Glu Ile Ser Glu Ile 
    130                 135                 140                 


Cys Glu Ala Lys Lys Met Asn Val Ala His Gly Leu Ala Trp Ser Phe 
145                 150                 155                 160 


Tyr Ile Gly Tyr Leu Lys Phe Leu Leu Pro Ala Leu Glu Val Asn Val 
                165                 170                 175     


Arg Glu Tyr Ser Arg Arg Glu Arg Leu Ser Ser Pro Arg Leu His Ile 
            180                 185                 190         


Leu Leu Pro Leu Asn Ala Arg Val Pro Ser Lys Pro Glu Glu Glu Asp 
        195                 200                 205             


Thr Asn Val Val Phe His Glu Asn Leu Pro Asp Leu Lys Leu Asp Arg 
    210                 215                 220                 


Ala Gly Val Arg Lys Arg Ser Tyr Thr Asn Ser Val Tyr Lys Ile Thr 
225                 230                 235                 240 


His Asn Asn Glu Thr Phe Ser Cys Ile Leu Glu Tyr Ala Thr Pro Leu 
                245                 250                 255     


Leu Thr Leu Tyr Gln Met Ser Gln Glu Ser Ser Ala Gly Phe Gly Glu 
            260                 265                 270         


Arg Glu Arg Lys Gln Gln Val Leu Leu Phe Tyr Arg Thr Leu Ser Gln 
        275                 280                 285             


Ile Leu Asp Asn Ser Leu Glu Cys Arg Asn Arg Tyr Arg Leu Ile Leu 
    290                 295                 300                 


Leu Asn Asp Glu His Thr Gly Asp Pro His Tyr Leu Ser Arg Glu Leu 
305                 310                 315                 320 


Phe Gln Asn Leu Lys Gln Gln Asp Gly Glu Ile Phe Met Asp Pro Thr 
                325                 330                 335     


Asn Glu Val His Pro Val Pro Glu Glu Gly Pro Val Gly Asn Cys Asn 
            340                 345                 350         


Gly Ala Leu Gln Ala Thr Phe His Glu Glu Pro Met Ser Asp Glu Pro 
        355                 360                 365             


Thr Leu Met Phe Ser Arg Pro Gln Ser Leu Arg Ser Glu Pro Val Glu 
    370                 375                 380                 


Thr Thr Asp Tyr Phe Asn Pro Ser Ser Ala Met Lys Gln Asn 
385                 390                 395             


<210>  24
<211>  298
<212>  PRT
<213>  Unknown

<220>
<223>  sp|A8E5V9|STING XENTR

<400>  24

Met Ala Cys Val Leu Ala Ile Gly Ser Ile Leu Phe Val Trp Ile Leu 
1               5                   10                  15      


Gly Lys Gly Lys Tyr Ser Gly Ala Gln Leu Ile Tyr Arg Met Ala Thr 
            20                  25                  30          


Asn Phe Ala Ile Ser Gln Gly Cys Cys Leu Val Thr Cys Ala Cys Glu 
        35                  40                  45              


Leu Thr Glu Glu Ile Lys His Leu His Thr Arg Tyr Asn Gly His Tyr 
    50                  55                  60                  


Trp Arg Ala Leu Lys Ala Ser Phe Asn Leu Ser Cys Ala Ala Phe Val 
65                  70                  75                  80  


Thr Ala Ile Leu Cys Tyr Val Phe Tyr Glu Pro Lys Leu Met Ala Ser 
                85                  90                  95      


Leu Pro Leu Thr Ile Asp Ile Thr Leu Thr Leu Leu Ser Trp Leu Phe 
            100                 105                 110         


Cys Trp Ile Leu Gly Ile Gln Gly Pro Thr Pro Ala Thr Ile Ser Glu 
        115                 120                 125             


Ile Thr Glu Ile Lys Gln Leu Asn Val Ala His Gly Leu Ala Trp Ser 
    130                 135                 140                 


Tyr Tyr Val Gly Tyr Leu Gln Phe Val Leu Pro Ala Leu Lys Glu Ser 
145                 150                 155                 160 


Ile Gln Lys Phe Asp Val Asp Glu Asn Ile Thr Phe Leu Lys Glu Ile 
                165                 170                 175     


Pro Pro Leu Tyr Ile Asp Arg Ala Gly Ile Lys Gly Arg Val Phe Lys 
            180                 185                 190         


Asn Asn Val Tyr Arg Ile Leu Asp Glu Asp Gly Arg Pro Tyr Asn Cys 
        195                 200                 205             


Ile Val Glu Tyr Ala Thr Pro Leu Ala Ser Leu Leu Lys Met Thr Asp 
    210                 215                 220                 


Ile Pro Ser Ala Ala Phe Ser Ala Asp Asp Arg Leu Gln Gln Thr Lys 
225                 230                 235                 240 


Leu Phe Tyr Arg Thr Leu Lys Asp Ile Leu Glu Asn Ala His Glu Leu 
                245                 250                 255     


Gln Asn Thr Tyr Arg Leu Ile Val Tyr Glu Asp Phe Pro Glu Thr Lys 
            260                 265                 270         


Asp His Ser Arg His Leu Leu Ser Gln Glu Ile Leu Lys His Ile Arg 
        275                 280                 285             


Gln Gln His Ser Glu Glu Tyr Ser Met Leu 
    290                 295             


<210>  25
<211>  375
<212>  PRT
<213>  Unknown

<220>
<223>  sp\E1C7U0\STING_CHICK

<400>  25

Met Pro Gln Asp Pro Ser Thr Arg Ser Ser Pro Ala Arg Leu Leu Ile 
1               5                   10                  15      


Pro Glu Pro Arg Ala Gly Arg Ala Arg His Ala Ala Cys Val Leu Leu 
            20                  25                  30          


Ala Val Cys Phe Val Val Leu Phe Leu Ser Gly Glu Pro Leu Ala Pro 
        35                  40                  45              


Ile Ile Arg Ser Val Cys Thr Gln Leu Ala Ala Leu Gln Leu Gly Val 
    50                  55                  60                  


Leu Leu Lys Gly Cys Cys Cys Leu Ala Glu Glu Ile Phe His Leu His 
65                  70                  75                  80  


Ser Arg His His Gly Ser Leu Trp Gln Val Leu Cys Ser Cys Phe Trp 
                85                  90                  95      


Tyr Leu Ala Leu Leu Leu Val Gly Gly Ser Ala Tyr Leu Asp Pro Pro 
            100                 105                 110         


Glu Asp Asn Gly His Ser Pro Arg Leu Ala Leu Thr Leu Ser Cys Leu 
        115                 120                 125             


Cys Gln Leu Leu Val Leu Ala Leu Gly Leu Gln Lys Leu Ser Ala Val 
    130                 135                 140                 


Glu Val Ser Glu Leu Thr Glu Ser Ser Lys Lys Asn Val Ala His Gly 
145                 150                 155                 160 


Leu Ala Trp Ser Tyr Tyr Ile Gly Tyr Leu Lys Val Val Pro Arg Leu 
                165                 170                 175     


Lys Glu Cys Met Glu Glu Leu Ser Arg Thr Asn Pro Met Leu Arg Ala 
            180                 185                 190         


His Arg Asp Thr Trp Lys Leu His Ile Leu Val Pro Leu Gly Cys Asp 
        195                 200                 205             


Ile Trp Asp Asp Leu Glu Lys Ala Asp Ser Asn Ile Gln Tyr Leu Ala 
    210                 215                 220                 


Asp Leu Pro Glu Thr Ile Leu Thr Arg Ala Gly Ile Lys Arg Arg Val 
225                 230                 235                 240 


Tyr Lys His Ser Leu Tyr Val Ile Arg Asp Lys Asp Asn Lys Leu Arg 
                245                 250                 255     


Pro Cys Val Leu Glu Phe Ala Ser Pro Leu Gln Thr Leu Cys Ala Met 
            260                 265                 270         


Ser Gln Asp Asp Cys Ala Ala Phe Ser Arg Glu Gln Arg Leu Glu Gln 
        275                 280                 285             


Ala Arg Leu Phe Tyr Arg Ser Leu Arg Asp Ile Leu Gly Ser Ser Lys 
    290                 295                 300                 


Glu Cys Ala Gly Leu Tyr Arg Leu Ile Ala Tyr Glu Glu Pro Ala Glu 
305                 310                 315                 320 


Pro Glu Ser His Phe Leu Ser Gly Leu Ile Leu Trp His Leu Gln Gln 
                325                 330                 335     


Gln Gln Arg Glu Glu Tyr Met Val Gln Glu Glu Leu Pro Leu Gly Thr 
            340                 345                 350         


Ser Ser Val Glu Leu Ser Leu Gln Val Ser Ser Ser Asp Leu Pro Gln 
        355                 360                 365             


Pro Leu Arg Ser Asp Cys Pro 
    370                 375 


<210>  26
<211>  379
<212>  PRT
<213>  Rattus norvegicus

<400>  26

Met Pro Tyr Ser Asn Leu His Pro Ser Ile Pro Arg Pro Arg Ser Tyr 
1               5                   10                  15      


Arg Phe Lys Leu Ala Ala Phe Val Leu Leu Val Gly Ser Leu Met Ser 
            20                  25                  30          


Leu Trp Met Thr Gly Glu Pro Pro Ser His Thr Leu His Tyr Leu Ala 
        35                  40                  45              


Leu His Val Ala Ser Gln Gln Leu Gly Leu Leu Leu Lys Lys Leu Cys 
    50                  55                  60                  


Cys Leu Ala Glu Glu Leu Cys His Val Gln Ser Arg Tyr Gln Gly Ser 
65                  70                  75                  80  


Tyr Trp Lys Ala Val Arg Ala Cys Val Gly Ser Pro Ile Cys Phe Met 
                85                  90                  95      


Ala Leu Ile Leu Leu Ser Phe Tyr Phe Tyr Cys Ser Leu Glu Asn Thr 
            100                 105                 110         


Ser Asp Leu Arg Leu Ala Trp His Leu Gly Ile Leu Val Leu Ser Lys 
        115                 120                 125             


Ser Leu Ser Met Thr Leu Asp Leu Gln Ser Leu Ala Pro Ala Glu Val 
    130                 135                 140                 


Ser Ala Val Cys Glu Glu Lys Asn Phe Asn Val Ala His Gly Leu Ala 
145                 150                 155                 160 


Trp Ser Tyr Tyr Ile Gly Tyr Leu Lys Leu Ile Leu Pro Gly Leu Gln 
                165                 170                 175     


Ala Arg Ile Arg Met Phe Asn Gln Leu His Asn Asn Met Leu Ser Gly 
            180                 185                 190         


Ala Gly Ser Arg Arg Leu Tyr Ile Leu Phe Pro Leu Asp Cys Gly Val 
        195                 200                 205             


Pro Asp Asp Leu Ser Val Ala Asp Pro Asn Ile Arg Phe Arg Asp Met 
    210                 215                 220                 


Leu Pro Gln Gln Asn Thr Asp Arg Ala Gly Val Lys Asn Arg Ala Tyr 
225                 230                 235                 240 


Ser Asn Ser Val Tyr Glu Leu Leu Glu Asn Gly Gln Pro Ala Gly Ala 
                245                 250                 255     


Cys Ile Leu Glu Tyr Ala Thr Pro Leu Gln Thr Leu Phe Ala Met Ser 
            260                 265                 270         


Gln Asp Gly Lys Ala Gly Phe Ser Arg Glu Asp Arg Leu Glu Gln Ala 
        275                 280                 285             


Lys Leu Phe Cys Arg Thr Leu Glu Glu Ile Leu Ala Asp Val Pro Glu 
    290                 295                 300                 


Ser Arg Asn His Cys Arg Leu Ile Val Tyr Gln Glu Ser Glu Glu Gly 
305                 310                 315                 320 


Asn Ser Phe Ser Leu Ser Gln Glu Val Leu Arg His Ile Arg Gln Glu 
                325                 330                 335     


Glu Lys Glu Glu Val Thr Met Ser Gly Pro Pro Thr Ser Val Ala Pro 
            340                 345                 350         


Arg Pro Ser Leu Leu Ser Gln Glu Pro Arg Leu Leu Ile Ser Gly Met 
        355                 360                 365             


Glu Gln Pro Leu Pro Leu Arg Thr Asp Leu Ile 
    370                 375                 


<210>  27
<211>  341
<212>  PRT
<213>  Mus musculus

<400>  27

Met Pro Tyr Ser Asn Leu His Pro Ala Ile Pro Arg Pro Arg Gly His 
1               5                   10                  15      


Arg Ser Lys Tyr Val Ala Leu Ile Phe Leu Val Ala Ser Leu Met Ile 
            20                  25                  30          


Leu Trp Val Ala Lys Asp Pro Pro Asn His Thr Leu Lys Tyr Leu Ala 
        35                  40                  45              


Leu His Leu Ala Ser His Glu Leu Gly Leu Leu Leu Lys Asn Leu Cys 
    50                  55                  60                  


Cys Leu Ala Glu Glu Leu Cys His Val Gln Ser Arg Tyr Gln Gly Ser 
65                  70                  75                  80  


Tyr Trp Lys Ala Val Arg Ala Cys Leu Gly Cys Pro Ile His Cys Met 
                85                  90                  95      


Ala Met Ile Leu Leu Ser Ser Tyr Phe Tyr Phe Leu Gln Asn Thr Ala 
            100                 105                 110         


Asp Ile Tyr Leu Ser Trp Met Phe Gly Leu Leu Val Leu Tyr Lys Ser 
        115                 120                 125             


Leu Ser Met Leu Leu Gly Leu Gln Ser Leu Thr Pro Ala Glu Val Ser 
    130                 135                 140                 


Ala Val Cys Glu Glu Lys Lys Leu Asn Val Ala His Gly Leu Ala Trp 
145                 150                 155                 160 


Ser Tyr Tyr Ile Gly Tyr Leu Arg Leu Ile Leu Pro Gly Leu Gln Ala 
                165                 170                 175     


Arg Ile Arg Met Phe Asn Gln Leu His Asn Asn Met Leu Ser Gly Ala 
            180                 185                 190         


Gly Ser Arg Arg Leu Tyr Ile Leu Phe Pro Leu Asp Cys Gly Val Pro 
        195                 200                 205             


Asp Asn Leu Ser Val Val Asp Pro Asn Ile Arg Phe Arg Asp Met Leu 
    210                 215                 220                 


Pro Gln Gln Asn Ile Asp Arg Ala Gly Ile Lys Asn Arg Val Tyr Ser 
225                 230                 235                 240 


Asn Ser Val Tyr Glu Ile Leu Glu Asn Gly Gln Pro Ala Gly Val Cys 
                245                 250                 255     


Ile Leu Glu Tyr Ala Thr Pro Leu Gln Thr Leu Phe Ala Met Ser Gln 
            260                 265                 270         


Asp Ala Lys Ala Gly Phe Ser Arg Glu Asp Arg Leu Glu Gln Ala Lys 
        275                 280                 285             


Leu Phe Cys Arg Thr Leu Glu Glu Ile Leu Glu Asp Val Pro Glu Ser 
    290                 295                 300                 


Arg Asn Asn Cys Arg Leu Ile Val Tyr Gln Glu Pro Thr Val Leu Ser 
305                 310                 315                 320 


Gln Glu Pro Arg Leu Leu Ile Ser Gly Met Asp Gln Pro Leu Pro Leu 
                325                 330                 335     


Arg Thr Asp Leu Ile 
            340     


<210>  28
<211>  389
<212>  PRT
<213>  Unknown

<220>
<223>  tr|H9YZQ6|H9YZQ6 MACMU

<400>  28

Met Thr Arg Ser Ser Leu His Pro Ser Ile Pro Cys Pro Arg Gly His 
1               5                   10                  15      


Gly Ala Gln Lys Ala Ala Leu Val Leu Leu Thr Ala Cys Leu Gly Thr 
            20                  25                  30          


Leu Trp Gly Leu Gly Glu Ser Pro Glu His Ile Leu Arg Cys Leu Val 
        35                  40                  45              


Leu His Leu Ala Ser Leu Gln Leu Gly Gln Leu Leu Asn Gly Val Cys 
    50                  55                  60                  


Ser Leu Ala Glu Glu Leu Arg His Ile His Ser Arg Tyr Arg Asp Ser 
65                  70                  75                  80  


Tyr Trp Arg Thr Val Arg Ala Cys Leu Gly Cys Pro Phe His Arg Gly 
                85                  90                  95      


Thr Leu Leu Leu Leu Ser Gly Tyr Phe Tyr Tyr Ser Leu Pro Asn Ala 
            100                 105                 110         


Val Gly Leu Pro Phe Thr Trp Met Leu Ala Leu Leu Gly Leu Ser Gln 
        115                 120                 125             


Ala Leu Asn Ile Leu Leu Gly Leu Lys Gly Leu Thr Pro Ala Glu Ile 
    130                 135                 140                 


Ser Ala Val Cys Glu Lys Gly Asn Phe Asn Val Ala His Gly Leu Ala 
145                 150                 155                 160 


Trp Ser Tyr Tyr Ile Gly Tyr Leu Arg Leu Ile Leu Pro Gly Leu Gln 
                165                 170                 175     


Ala Arg Ile Gln Thr Tyr Asn Gln His Tyr Asn Asn Leu Leu Arg Gly 
            180                 185                 190         


Ala Val Ser Gln Arg Leu Tyr Ile Leu Leu Pro Leu Asp Cys Gly Val 
        195                 200                 205             


Pro Asp Asn Leu Ser Leu Asp Cys Gly Val Pro Asp Asn Leu Ser Met 
    210                 215                 220                 


Ala Asp Pro Asn Ile Arg Phe Leu Asp Lys Leu Pro Gln Gln Thr Ala 
225                 230                 235                 240 


Asp Arg Ala Gly Ile Lys Asp Arg Val Tyr Ser Asn Ser Ile Tyr Glu 
                245                 250                 255     


Leu Leu Glu Asn Gly Gln Arg Ala Gly Thr Cys Val Leu Glu Tyr Ala 
            260                 265                 270         


Thr Pro Leu Gln Thr Leu Phe Ala Met Ser Gln Tyr Gly Gln Ala Gly 
        275                 280                 285             


Phe Ser Arg Glu Asp Arg Leu Glu Gln Val Lys Leu Phe Cys Arg Thr 
    290                 295                 300                 


Leu Glu Asp Ile Leu Ala Asp Asn Pro Glu Ser Gln Asn Asn Cys Arg 
305                 310                 315                 320 


Leu Ile Val Tyr Ser Glu Pro Ala Asp Asp Ser Ser Phe Ser Leu Ser 
                325                 330                 335     


Gln Glu Val Leu Arg His Leu Arg Gln Glu Glu Lys Glu Glu Val Thr 
            340                 345                 350         


Val Gly Ser Leu Lys Asn Ser Ala Val Pro Ser Thr Ser Thr Met Ser 
        355                 360                 365             


Gln Glu Pro Glu Leu Leu Ile Ser Gly Met Glu Lys Pro Leu Pro Leu 
    370                 375                 380                 


Arg Thr Asp Phe Ser 
385                 


<210>  29
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Pro His Ser Ser Leu His Pro Ser Ile Pro Cys Pro Arg Gly His 
1               5                   10                  15      


Gly Ala Gln Lys Ala Ala Leu Val Leu Leu Ser Ala Cys Leu Val Thr 
            20                  25                  30          


Leu Trp Gly Leu Gly Glu Pro Pro Glu His Thr Leu Arg Tyr Leu Val 
        35                  40                  45              


Leu His Leu Ala Ser Leu Gln Leu Gly Leu Leu Leu Asn Gly Val Cys 
    50                  55                  60                  


Ser Leu Ala Glu Glu Leu Arg His Ile His Ser Arg Tyr Arg Gly Ser 
65                  70                  75                  80  


Tyr Trp Arg Thr Val Arg Ala Cys Leu Gly Cys Pro Leu Arg Arg Gly 
                85                  90                  95      


Ala Leu Leu Leu Leu Ser Ile Tyr Phe Tyr Tyr Ser Leu Pro Asn Ala 
            100                 105                 110         


Val Gly Pro Pro Phe Thr Trp Met Leu Ala Leu Leu Gly Leu Ser Gln 
        115                 120                 125             


Ala Leu Asn Ile Leu Leu Gly Leu Lys Gly Leu Ala Pro Ala Glu Ile 
    130                 135                 140                 


Ser Ala Val Cys Glu Lys Gly Asn Phe Asn Val Ala His Gly Leu Ala 
145                 150                 155                 160 


Trp Ser Tyr Tyr Ile Gly Tyr Leu Arg Leu Ile Leu Pro Glu Leu Gln 
                165                 170                 175     


Ala Arg Ile Arg Thr Tyr Asn Gln His Tyr Asn Asn Leu Leu Arg Gly 
            180                 185                 190         


Ala Val Ser Gln Arg Leu Tyr Ile Leu Leu Pro Leu Asp Cys Gly Val 
        195                 200                 205             


Pro Asp Asn Leu Ser Met Ala Asp Pro Asn Ile Arg Phe Leu Asp Lys 
    210                 215                 220                 


Leu Pro Gln Gln Thr Gly Asp His Ala Gly Ile Lys Asp Arg Val Tyr 
225                 230                 235                 240 


Ser Asn Ser Ile Tyr Glu Leu Leu Glu Asn Gly Gln Arg Ala Gly Thr 
                245                 250                 255     


Cys Val Leu Glu Tyr Ala Thr Pro Leu Gln Thr Leu Phe Ala Met Ser 
            260                 265                 270         


Gln Tyr Ser Gln Ala Gly Phe Ser Arg Glu Asp Arg Leu Glu Gln Ala 
        275                 280                 285             


Lys Leu Phe Cys Arg Thr Leu Glu Asp Ile Leu Ala Asp Ala Pro Glu 
    290                 295                 300                 


Ser Gln Asn Asn Cys Arg Leu Ile Ala Tyr Gln Glu Pro Ala Asp Asp 
305                 310                 315                 320 


Ser Ser Phe Ser Leu Ser Gln Glu Val Leu Arg His Leu Arg Gln Glu 
                325                 330                 335     


Glu Lys Glu Glu Val Thr Val Gly Ser Leu Lys Thr Ser Ala Val Pro 
            340                 345                 350         


Ser Thr Ser Thr Met Ser Gln Glu Pro Glu Leu Leu Ile Ser Gly Met 
        355                 360                 365             


Glu Lys Pro Leu Pro Leu Arg Thr Asp Phe Ser 
    370                 375                 


<210>  30
<211>  379
<212>  PRT
<213>  Panthera pardus

<400>  30

Met Pro His Ser Ser Leu His Pro Ser Ile Pro Cys Pro Arg Gly His 
1               5                   10                  15      


Gly Ala Gln Lys Ala Ala Leu Val Leu Leu Ser Ala Cys Leu Val Thr 
            20                  25                  30          


Leu Trp Gly Leu Gly Glu Pro Pro Glu His Thr Leu Arg Tyr Leu Val 
        35                  40                  45              


Leu His Leu Ala Ser Leu Gln Leu Gly Leu Leu Leu Asn Gly Val Cys 
    50                  55                  60                  


Ser Leu Ala Glu Glu Leu Arg His Ile His Ser Arg Tyr Trp Gly Ser 
65                  70                  75                  80  


Tyr Trp Arg Thr Val Arg Ala Cys Leu Gly Cys Pro Leu Arg Arg Gly 
                85                  90                  95      


Ala Leu Leu Leu Leu Ser Ile Tyr Phe Tyr Tyr Ser Leu Pro Asn Ala 
            100                 105                 110         


Val Gly Pro Pro Phe Thr Trp Met Leu Ala Leu Leu Gly Leu Ser Gln 
        115                 120                 125             


Ala Leu Asn Ile Leu Leu Gly Leu Lys Gly Leu Ala Pro Ala Glu Ile 
    130                 135                 140                 


Ser Ala Val Cys Glu Lys Gly Asn Phe Asn Val Ala His Gly Leu Ala 
145                 150                 155                 160 


Trp Ser Tyr Tyr Ile Gly Tyr Leu Arg Leu Ile Leu Pro Glu Leu Gln 
                165                 170                 175     


Ala Arg Ile Arg Thr Tyr Asn Gln His Tyr Asn Asn Leu Leu Arg Gly 
            180                 185                 190         


Ala Val Ser Gln Arg Leu Tyr Ile Leu Leu Pro Leu Asp Cys Gly Val 
        195                 200                 205             


Pro Asp Asn Leu Ser Met Ala Asp Pro Asn Ile Arg Phe Leu Asp Lys 
    210                 215                 220                 


Leu Pro Gln Gln Thr Ala Asp Arg Ala Gly Ile Lys Asp Arg Val Tyr 
225                 230                 235                 240 


Ser Asn Ser Ile Tyr Glu Leu Leu Glu Asn Gly Gln Arg Ala Gly Thr 
                245                 250                 255     


Cys Val Leu Glu Tyr Ala Thr Pro Leu Gln Thr Leu Phe Ala Met Ser 
            260                 265                 270         


Gln Tyr Ser Gln Ala Gly Phe Ser Arg Glu Asp Arg Leu Glu Gln Ala 
        275                 280                 285             


Lys Leu Phe Cys Arg Thr Leu Glu Asp Ile Leu Ala Asp Ala Pro Glu 
    290                 295                 300                 


Ser Gln Asn Asn Cys Arg Leu Ile Ala Tyr Gln Glu Pro Ala Asp Asp 
305                 310                 315                 320 


Ser Ser Phe Ser Leu Ser Gln Glu Val Leu Arg His Leu Arg Gln Glu 
                325                 330                 335     


Glu Lys Glu Glu Val Thr Val Gly Ser Leu Lys Thr Ser Ala Val Pro 
            340                 345                 350         


Ser Thr Ser Thr Met Ser Gln Glu Pro Glu Leu Leu Ile Ser Gly Met 
        355                 360                 365             


Glu Lys Pro Leu Pro Leu Arg Thr Asp Phe Ser 
    370                 375                 


<210>  31
<211>  378
<212>  PRT
<213>  Bos taurus

<400>  31

Met Pro His Ser Ser Leu His Pro Ser Ile Pro Gln Pro Arg Gly Leu 
1               5                   10                  15      


Arg Ala Gln Lys Ala Ala Leu Val Leu Leu Ser Ala Cys Leu Val Ala 
            20                  25                  30          


Leu Trp Gly Leu Gly Glu Pro Pro Asp Tyr Thr Leu Lys Trp Leu Val 
        35                  40                  45              


Leu His Leu Ala Ser Gln Gln Met Gly Leu Leu Ile Lys Gly Ile Cys 
    50                  55                  60                  


Ser Leu Ala Glu Glu Leu Cys His Val His Ser Arg Tyr His Gly Ser 
65                  70                  75                  80  


Tyr Trp Arg Ala Val Arg Ala Cys Leu Cys Ser Ser Met Arg Cys Gly 
                85                  90                  95      


Ala Leu Leu Leu Leu Ser Cys Tyr Phe Tyr Cys Ser Leu Pro Asn Met 
            100                 105                 110         


Ala Asp Leu Pro Phe Thr Trp Met Leu Ala Leu Leu Gly Leu Ser Gln 
        115                 120                 125             


Ala Leu Asn Ile Leu Leu Gly Leu Gln Gly Leu Ala Pro Ala Glu Val 
    130                 135                 140                 


Ser Ala Ile Cys Glu Lys Arg Asn Phe Asn Val Ala His Gly Leu Ala 
145                 150                 155                 160 


Trp Ser Tyr Tyr Ile Gly Tyr Leu Arg Leu Ile Leu Pro Gly Leu Pro 
                165                 170                 175     


Ala Arg Ile Gln Ile Tyr Asn Gln Phe His Asn Asn Thr Leu Gln Gly 
            180                 185                 190         


Ala Gly Ser His Arg Leu His Ile Leu Phe Pro Leu Asp Cys Gly Val 
        195                 200                 205             


Pro Asp Asp Leu Asn Val Ala Asp Pro Asn Ile Arg Phe Leu His Glu 
    210                 215                 220                 


Leu Pro Gln Gln Ser Ala Asp Arg Ala Gly Ile Lys Gly Arg Val Tyr 
225                 230                 235                 240 


Thr Asn Ser Ile Tyr Glu Leu Leu Glu Asn Gly Gln Arg Ala Gly Val 
                245                 250                 255     


Cys Val Leu Glu Tyr Ala Thr Pro Leu Gln Thr Leu Phe Ala Met Ser 
            260                 265                 270         


Gln Asp Gly Arg Ala Gly Phe Ser Arg Glu Asp Arg Leu Glu Gln Ala 
        275                 280                 285             


Lys Leu Phe Cys Arg Thr Leu Glu Asp Ile Leu Ala Asn Ala Pro Glu 
    290                 295                 300                 


Ser Gln Asn Asn Cys Arg Leu Ile Val Tyr Gln Glu Pro Ala Glu Gly 
305                 310                 315                 320 


Ser Ser Phe Ser Leu Ser Gln Glu Ile Leu Gln His Leu Arg Gln Glu 
                325                 330                 335     


Glu Arg Glu Val Thr Met Gly Ser Thr Glu Thr Ser Val Met Pro Gly 
            340                 345                 350         


Ser Ser Val Leu Ser Gln Glu Pro Glu Leu Leu Ile Ser Gly Leu Glu 
        355                 360                 365             


Lys Pro Leu Pro Leu Arg Ser Asp Val Phe 
    370                 375             


<210>  32
<211>  385
<212>  PRT
<213>  Sus scrofa

<400>  32

Met Pro Tyr Ser Ser Leu His Pro Ser Ile Pro Gln Pro Arg Gly Leu 
1               5                   10                  15      


Arg Ala Gln Val Ala Ala Leu Val Leu Leu Gly Ala Cys Leu Val Ala 
            20                  25                  30          


Leu Trp Gly Leu Gly Glu Leu Pro Glu Tyr Thr Leu Arg Trp Leu Val 
        35                  40                  45              


Leu His Leu Ala Ser Gln Gln Ile Gly Leu Leu Val Lys Gly Leu Cys 
    50                  55                  60                  


Ser Leu Ala Glu Glu Leu Cys His Val His Ser Arg Tyr Gln Ser Ser 
65                  70                  75                  80  


Tyr Trp Arg Ala Ala Arg Ala Cys Leu Gly Cys Pro Ile Arg Cys Gly 
                85                  90                  95      


Ala Leu Leu Leu Leu Ser Cys Tyr Phe Tyr Phe Ser Ile Arg Asp Lys 
            100                 105                 110         


Ala Gly Leu Pro Leu Pro Trp Met Leu Ala Leu Leu Gly Leu Ser Gln 
        115                 120                 125             


Ala Leu Asn Ile Leu Leu Gly Leu Gln His Leu Ala Pro Ala Glu Val 
    130                 135                 140                 


Ser Ala Ile Cys Glu Lys Arg Asn Phe Asn Val Ala His Gly Leu Ala 
145                 150                 155                 160 


Trp Ser Tyr Tyr Ile Gly Tyr Leu Arg Leu Ile Leu Pro Gly Leu Arg 
                165                 170                 175     


Ala Arg Ile Gln Ala Tyr Asn Gln Arg His Lys Asn Val Leu Gly Gly 
            180                 185                 190         


Ile Gly Asn His Arg Leu His Ile Leu Phe Pro Leu Asp Cys Gly Val 
        195                 200                 205             


Pro Asp Asp Leu Ser Gly Val Pro Asp Asp Leu Ser Val Ala Asp Pro 
    210                 215                 220                 


Asn Ile Arg Phe Leu His Glu Leu Pro Gln Gln Ser Ala Asp Arg Ala 
225                 230                 235                 240 


Gly Ile Lys Gly Arg Val Tyr Thr Asn Ser Ile Tyr Glu Leu Leu Glu 
                245                 250                 255     


Asn Gly Gln Pro Ala Gly Val Cys Val Leu Gly Tyr Ala Thr Pro Leu 
            260                 265                 270         


Gln Thr Leu Phe Ala Met Ser Gln Asp Gly Arg Ala Gly Phe Ser Arg 
        275                 280                 285             


Glu Asp Arg Leu Glu Gln Ala Lys Leu Phe Cys Arg Thr Leu Glu Asp 
    290                 295                 300                 


Ile Leu Ala Asp Ala Pro Glu Ala Gln Asn Asn Cys Arg Leu Ile Val 
305                 310                 315                 320 


Tyr Gln Glu Pro Thr Glu Gly Gly Ser Phe Ser Leu Ser Gln Glu Ile 
                325                 330                 335     


Leu Arg His Leu Arg Gln Glu Glu Arg Glu Val Thr Met Gly Ser Ala 
            340                 345                 350         


Glu Thr Ser Val Val Pro Thr Ser Ser Thr Leu Ser Gln Glu Pro Glu 
        355                 360                 365             


Leu Leu Ile Ser Gly Met Glu Gln Pro Leu Pro Leu Arg Ser Asp Ile 
    370                 375                 380                 


Phe 
385 


