                         SEQUENCE LISTING

<110>  FZATA, INC.
       Hua, YU
       Lydia, NYASAE
       Kyle, HOBAN
       Zhiyong, YANG
 
<120>  GENETICALLY-MODIFIED SACCHAROMYCES YEAST STRAINS AS PREVENTATIVE 
       AND THERAPEUTIC AGENTS

<130>  130507-0125

<140>  PCT/US2022/033037
<141>  2022-06-10

<150>  63/209,651
<151>  2021-06-11

<150>  63/299,693
<151>  2022-01-14

<150>  63/317,385
<151>  2022-03-07

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHFR and DFR1 amino acid sequence

<400>  1

Val Arg Pro Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Lys 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Arg Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Asp Arg Ile Asn Ile Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Arg Gly Ala His Phe Leu Ala Lys Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Arg Leu Ile Glu Gln Pro Glu Leu Ala Ser Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Tyr Gln Glu Ala Met Asn Gln Pro 
        115                 120                 125             


Gly His Leu Arg Leu Phe Val Thr Arg Ile Met Gln Glu Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Gly Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Glu Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Lys Asp 
            180                 185     


<210>  2
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHFR and DFR1 amino acid sequence

<400>  2

Met Ala Gly Gly Lys Ile Pro Ile Val Gly Ile Val Ala Cys Leu Gln 
1               5                   10                  15      


Pro Glu Met Gly Ile Gly Phe Arg Gly Gly Leu Pro Trp Arg Leu Pro 
            20                  25                  30          


Ser Glu Met Lys Tyr Phe Arg Gln Val Thr Ser Leu Thr Lys Asp Pro 
        35                  40                  45              


Asn Lys Lys Asn Ala Leu Ile Met Gly Arg Lys Thr Trp Glu Ser Ile 
    50                  55                  60                  


Pro Pro Lys Phe Arg Pro Leu Pro Asn Arg Met Asn Val Ile Ile Ser 
65                  70                  75                  80  


Arg Ser Phe Lys Asp Asp Phe Val His Asp Lys Glu Arg Ser Ile Val 
                85                  90                  95      


Gln Ser Asn Ser Leu Ala Asn Ala Ile Met Asn Leu Glu Ser Asn Phe 
            100                 105                 110         


Lys Glu His Leu Glu Arg Ile Tyr Val Ile Gly Gly Gly Glu Val Tyr 
        115                 120                 125             


Ser Gln Ile Phe Ser Ile Thr Asp His Trp Leu Ile Thr Lys Ile Asn 
    130                 135                 140                 


Pro Leu Asp Lys Asn Ala Thr Pro Ala Met Asp Thr Phe Leu Asp Ala 
145                 150                 155                 160 


Lys Lys Leu Glu Glu Val Phe Ser Glu Gln Asp Pro Ala Gln Leu Lys 
                165                 170                 175     


Glu Phe Leu Pro Pro Lys Val Glu Leu Pro Glu Thr Asp Cys Asp Gln 
            180                 185                 190         


Arg Tyr Ser Leu Glu Glu Lys Gly Tyr Cys Phe Glu Phe Thr Leu Tyr 
        195                 200                 205             


Asn Arg Lys 
    210     


<210>  3
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wFc (wild type human Fc)

<400>  3

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  4
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mFc (mutant human Fc)

<400>  4

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  5
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABAB sequence (FZ002)

<400>  5

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Ser 
            20                  25                  30          


Ser Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Asp Ser Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Arg Ala Thr Met Cys Gly Val Phe Pro Leu Ser Pro Tyr 
            100                 105                 110         


Gly Lys Asp Asp Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Gly Ile 
                165                 170                 175     


Gly Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Ala Val Ser Tyr 
            180                 185                 190         


Ile Ser Ala Ser Ala Arg Thr Ile Leu Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Lys Arg Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Arg Arg Phe Ser Ala Ser Ser Val Asn Arg Trp Leu Ala Asp Asp Tyr 
                245                 250                 255     


Asp Val Trp Gly Arg Gly Thr Gln Val Ala Val Ser Ser Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Leu Gln 
        275                 280                 285             


Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    290                 295                 300                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Val Met Thr 
305                 310                 315                 320 


Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile Ala Thr Ile 
                325                 330                 335     


Asn Thr Asp Gly Ser Thr Met Arg Asp Asp Ser Thr Lys Gly Arg Phe 
            340                 345                 350         


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Thr 
        355                 360                 365             


Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Gly Arg 
    370                 375                 380                 


Val Ile Ser Ala Ser Ala Ile Arg Gly Ala Val Arg Gly Pro Gly Thr 
385                 390                 395                 400 


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            420                 425                 430         


Val Gln Thr Gly Gly Ser Leu Arg Leu Ser Cys Ala Ser Ser Gly Ser 
        435                 440                 445             


Ile Ala Gly Phe Glu Thr Val Thr Trp Ser Arg Gln Ala Pro Gly Lys 
    450                 455                 460                 


Ser Leu Gln Trp Val Ala Ser Met Thr Lys Thr Asn Asn Glu Ile Tyr 
465                 470                 475                 480 


Ser Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys 
                485                 490                 495     


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly 
            500                 505                 510         


Val Tyr Phe Cys Lys Gly Pro Glu Leu Arg Gly Gln Gly Ile Gln Val 
        515                 520                 525             


Thr Val Ser Ser 
    530         


<210>  6
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF-alfa antibody amino acid sequence (FZ006)

<400>  6

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Val Asp Asn Asp Gly Phe Thr Met His Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Gln Tyr Ser Lys Phe Val Glu Ser Tyr Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  7
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF-alfa antibody amino acid sequence (FZ006m)

<400>  7

Gln Val Gln Leu Gln Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Ser Ile 
            20                  25                  30          


Ile Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Gly Ala Val Ser Trp Ser Gly Gly Thr Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Leu Gly Arg Phe Glu Ile Ser Arg Asp Ser Ala Arg Lys Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Pro Tyr Gln Lys Tyr Asn Trp Ala Ser Ala Ser Tyr Asn 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    130                 135                 140                 


Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Gly Thr Phe Ser Ser Ile Ile Met Ala Trp Phe 
                165                 170                 175     


Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Gly Ala Val Ser Trp 
            180                 185                 190         


Ser Gly Gly Thr Thr Val Tyr Ala Asp Ser Val Leu Gly Arg Phe Glu 
        195                 200                 205             


Ile Ser Arg Asp Ser Ala Arg Lys Ser Val Tyr Leu Gln Met Asn Ser 
    210                 215                 220                 


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Pro Tyr 
225                 230                 235                 240 


Gln Lys Tyr Asn Trp Ala Ser Ala Ser Tyr Asn Val Trp Gly Gln Gly 
                245                 250                 255     


Thr Gln Val Thr Val Ser Ser 
            260             


<210>  8
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bi-specific antibodies against IL-17A and TNF-alfa amino acid 
       sequence (FZ008a)

<400>  8

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Val Asp Asn Asp Gly Phe Thr Met His Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Gln Tyr Ser Lys Phe Val Glu Ser Tyr Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gln Ala Gly Gln Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Gln Gln Val 
    130                 135                 140                 


Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ala Thr Ser Pro Met 
                165                 170                 175     


Gly Trp Leu Arg Gln Ala Pro Gly Lys Gly Thr Glu Phe Val Ala Ala 
            180                 185                 190         


Ile Ser Pro Ser Gly Gly Asp Arg Ile Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Gly Tyr Phe Ile Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Val 
225                 230                 235                 240 


Arg Arg Arg Phe Asp Gly Thr Ser Tyr Tyr Thr Gly Asp Tyr Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265         


<210>  9
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bi-specific antibodies against IL-17A and TNF-alfa amino acid 
       sequence(FZ008b-VHH1)

<400>  9

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Val Asp Asn Asp Gly Phe Thr Met His Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Gln Tyr Ser Lys Phe Val Glu Ser Tyr Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gln Ala Gly Pro 
        115                 120                 125 


<210>  10
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bi-specific antibodies against IL-17A and TNF-alfa amino acid 
       sequence (FZ008b-VHH2)

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ala Thr Ser 
            20                  25                  30          


Pro Met Gly Trp Leu Arg Gln Ala Pro Gly Lys Gly Thr Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Pro Ser Gly Gly Asp Arg Ile Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gly Tyr Phe Ile Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Arg Arg Arg Phe Asp Gly Thr Ser Tyr Tyr Thr Gly Asp Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  11
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-22 amino acid sequence (FZ010m)

<400>  11

Leu Pro Val Asn Thr Arg Cys Lys Leu Glu Val Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Val Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe Arg 
        35                  40                  45              


Gly Val Ser Ala Lys Asp Gln Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Asp Val Leu Leu Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Thr Lys Leu Ser Asn Gln Leu 
                85                  90                  95      


Ser Ser Cys His Ile Ser Gly Asp Asp Gln Asn Ile Gln Lys Asn Val 
            100                 105                 110         


Arg Arg Leu Lys Glu Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Val 
145     


<210>  12
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-22 amino acid sequence (FZ010)

<400>  12

Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile 
145     


<210>  13
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Rotavirus VHH amino acid sequence (FZ014)

<400>  13

Met Ala Asp Val Gln Leu Gln Ala Ser Gly Gly Gly Phe Val Gln Pro 
1               5                   10                  15      


Gly Asp Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ser Ile Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Thr Ile Ser Ser Ser Asp Ser Pro Trp Tyr Gly Glu Pro 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Val Ala Arg Val Asn Ala Lys Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu His Leu Asn Arg Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Gly Ser Val Gln His Met Ala Asn Glu Asn Glu Tyr Val 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  14
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bi-specific VHHs-Fc (FZ016a)

<400>  14

Gln Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Asn Phe Ser Ile Asn 
            20                  25                  30          


Gly Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Asn Gly Gly Tyr Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Asn Phe Gln Ile His Arg Ser Gly Ala Asp Tyr Val Arg Asn Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ala Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Lys Leu Gln Gln 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Glu Ser Thr Ile Ser Ile Asn Thr Leu Gly Trp Tyr Arg 
                165                 170                 175     


Gln Ala Pro Gly Asn Gln Arg Glu Leu Val Ala Thr Ile Thr Thr Gly 
            180                 185                 190         


Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        195                 200                 205             


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Asn Leu Glu 
    210                 215                 220                 


Pro Gly Asp Thr Ala Val Tyr Tyr Cys Asn Leu Lys Arg Arg Asp Leu 
225                 230                 235                 240 


Gln Ser Arg Phe Gly Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
                245                 250                 255     


Ser Ser 
        


<210>  15
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bi-specific VHHs-Fc (FZ016b)

<400>  15

Gln Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Asn Phe Ser Ile Asn 
            20                  25                  30          


Gly Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Asn Gly Gly Tyr Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Asn Phe Gln Ile His Arg Ser Gly Ala Asp Tyr Val Arg Asn Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ala Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Val Ala Ser Glu Ser Thr Val Ser Ile Asn Ile Met Gly Trp Tyr Arg 
                165                 170                 175     


Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Thr Ile Thr Thr Gly 
            180                 185                 190         


Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        195                 200                 205             


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Glu 
    210                 215                 220                 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Leu Lys Arg Arg Asp Leu 
225                 230                 235                 240 


Gln Ala Arg Phe Gly Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
                245                 250                 255     


Ser Ser 
        


<210>  16
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mono-specific (FZ016c)

<400>  16

Gln Val Lys Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Ser Thr Ile Ser Ile Asn 
            20                  25                  30          


Thr Leu Gly Trp Tyr Arg Gln Ala Pro Gly Asn Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Thr Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Glu Pro Gly Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Lys Arg Arg Asp Leu Gln Ser Arg Phe Gly Gly Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Tyr Pro Tyr Asp Val Pro Asp Tyr 
        115                 120                 125             


Ala 
    


<210>  17
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 amino acid sequence (FZ022a)

<400>  17

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  18
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leptin amino acid sequence (FZ024)

<400>  18

Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys Thr Leu Ile Lys Thr 
1               5                   10                  15      


Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr Gln Ser Val Ser Ser 
            20                  25                  30          


Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro Gly Leu His Pro Ile 
        35                  40                  45              


Leu Thr Leu Ser Lys Met Asp Gln Thr Leu Ala Val Tyr Gln Gln Ile 
    50                  55                  60                  


Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln Ile Ser Asn Asp Leu 
65                  70                  75                  80  


Glu Asn Leu Arg Asp Leu Leu His Val Leu Ala Phe Ser Lys Ser Cys 
                85                  90                  95      


His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu Asp Ser Leu Gly Gly 
            100                 105                 110         


Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val Val Ala Leu Ser Arg 
        115                 120                 125             


Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln Leu Asp Leu Ser Pro 
    130                 135                 140                 


Gly Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
145                 150                 155 


<210>  19
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-TNF-alfa IgG1 acid sequence (FZ026-HC)

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Asp Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  20
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-TNF-alfa IgG1 acid sequence (FZ026-LC)

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  21
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH against cwp84 fused with Lysin domain amino acid 
       sequence(FZ028a)

<400>  21

Met Lys Ile Cys Ile Thr Val Gly His Ser Ile Leu Lys Ser Gly Ala 
1               5                   10                  15      


Cys Thr Ser Ala Asp Gly Val Val Asn Glu Tyr Gln Tyr Asn Lys Ser 
            20                  25                  30          


Leu Ala Pro Val Leu Ala Asp Thr Phe Arg Lys Glu Gly His Lys Val 
        35                  40                  45              


Asp Val Ile Ile Cys Pro Glu Lys Gln Phe Lys Thr Lys Asn Glu Glu 
    50                  55                  60                  


Lys Ser Tyr Lys Ile Pro Arg Val Asn Ser Gly Gly Tyr Asp Leu Leu 
65                  70                  75                  80  


Ile Glu Leu His Leu Asn Ala Ser Asn Gly Gln Gly Lys Gly Ser Glu 
                85                  90                  95      


Val Leu Tyr Tyr Ser Asn Lys Gly Leu Glu Tyr Ala Thr Arg Ile Cys 
            100                 105                 110         


Asp Lys Leu Gly Thr Val Phe Lys Asn Arg Gly Ala Lys Leu Asp Lys 
        115                 120                 125             


Arg Leu Tyr Ile Leu Asn Ser Ser Lys Pro Thr Ala Val Leu Ile Glu 
    130                 135                 140                 


Ser Phe Phe Cys Asp Asn Lys Glu Asp Tyr Asp Lys Ala Lys Lys Leu 
145                 150                 155                 160 


Gly His Glu Gly Ile Ala Lys Leu Ile Val Glu Gly Val Leu Asn Lys 
                165                 170                 175     


Asn Ile Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
        195                 200                 205             


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Thr Ser Thr Phe Pro 
    210                 215                 220                 


Ile Asn Glu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
225                 230                 235                 240 


Leu Val Ala Ala Ile Thr Arg Val Gly Thr Thr Asn Tyr Ala Asn Ser 
                245                 250                 255     


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Thr Ser Asn Thr Lys 
            260                 265                 270         


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
        275                 280                 285             


Val Tyr Tyr Cys Asn Val Asn Leu Phe Ala Asp Thr Gly Asn Tyr Trp 
    290                 295                 300                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
305                 310                 


<210>  22
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH against cwp84 fused with Lysin domain amino acid 
       sequence(FZ028b)

<400>  22

Met Lys Val Val Ile Ile Pro Gly His Thr Leu Ile Gly Lys Gly Thr 
1               5                   10                  15      


Gly Ala Val Gly Tyr Ile Asn Glu Ser Lys Glu Thr Arg Ile Leu Asn 
            20                  25                  30          


Asp Leu Ile Val Lys Trp Leu Lys Ile Gly Gly Ala Thr Val Tyr Thr 
        35                  40                  45              


Gly Arg Val Asp Glu Ser Ser Asn His Leu Ala Asp Gln Cys Ala Ile 
    50                  55                  60                  


Ala Asn Lys Gln Glu Thr Asp Leu Ala Val Gln Ile His Phe Asn Ser 
65                  70                  75                  80  


Asn Ala Thr Thr Ser Thr Pro Val Gly Thr Glu Thr Ile Tyr Lys Thr 
                85                  90                  95      


Asn Asn Gly Lys Thr Tyr Ala Glu Arg Val Asn Thr Arg Leu Ala Thr 
            100                 105                 110         


Val Phe Lys Asp Arg Gly Ala Lys Ser Asp Val Arg Gly Leu Tyr Trp 
        115                 120                 125             


Leu Asn His Thr Ile Ala Pro Ala Ile Leu Ile Glu Val Cys Phe Val 
    130                 135                 140                 


Asp Ser Lys Ala Asp Thr Asp Tyr Tyr Val Asn Asn Lys Asp Lys Val 
145                 150                 155                 160 


Ala Lys Leu Ile Ala Glu Gly Ile Leu Asn Lys Ser Gly Ser Gly Gly 
                165                 170                 175     


Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gln 
            180                 185                 190         


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser 
        195                 200                 205             


Leu Arg Leu Ser Cys Val Ala Ser Thr Ser Thr Phe Pro Ile Asn Glu 
    210                 215                 220                 


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
225                 230                 235                 240 


Ala Ile Thr Arg Val Gly Thr Thr Asn Tyr Ala Asn Ser Val Lys Gly 
                245                 250                 255     


Arg Phe Thr Ile Ser Arg Asp Lys Thr Ser Asn Thr Lys Asn Thr Val 
            260                 265                 270         


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
        275                 280                 285             


Cys Asn Val Asn Leu Phe Ala Asp Thr Gly Asn Tyr Trp Gly Gln Gly 
    290                 295                 300                 


Thr Leu Val Thr Val Ser Ser 
305                 310     


<210>  23
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 amino acid sequence (FZ022b)

<400>  23

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  24
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 amino acid sequences (FZ022c)

<400>  24

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  25
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-IL-17A antibody amino acid sequence (FZ004)

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ala Thr Ser 
            20                  25                  30          


Pro Met Gly Trp Leu Arg Gln Ala Pro Gly Lys Gly Thr Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Pro Ser Gly Gly Asp Arg Ile Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gly Tyr Phe Ile Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Arg Arg Arg Phe Asp Gly Thr Ser Tyr Tyr Thr Gly Asp Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  26
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Aprotinin amino acid sequence

<400>  26

Arg Pro Asp Phe Cys Leu Glu Pro Pro Tyr Thr Gly Pro Cys Lys Ala 
1               5                   10                  15      


Arg Ile Ile Arg Tyr Phe Tyr Asn Ala Lys Ala Gly Leu Cys Gln Thr 
            20                  25                  30          


Phe Val Tyr Gly Gly Cys Arg Ala Lys Arg Asn Asn Phe Lys Ser Ala 
        35                  40                  45              


Glu Asp Cys Met Arg Thr Cys Gly Gly Ala 
    50                  55              


<210>  27
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1L-10 amino acid sequence (FZ030)

<400>  27

Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


