                         SEQUENCE LISTING

<110>  Chimeron Bio Corporation
       Chendrimada, Jolly  M
       Chendrimada, Thimmaiah  P
 
<120>  SELF-AMPLIFYING RNA-BASED VLP VACCINES

<130>  37544-46558/US

<150>  63/208,884
<151>  2021-06-09

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  1273
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  1

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  2
<211>  3822
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  2
atgtttgtgt tcctggtgct tctgccactt gtttcctcac aatgcgtcaa tctcacaaca       60

agaacgcagc ttccgcctgc atatacaaat agtttcacca gaggcgttta ttatccagat      120

aaggtctttc gaagctctgt cctccattct acgcaagatc tgttcttgcc attcttttca      180

aacgtgacgt ggtttcacgc tattcacgtt tctggcacta atggcacgaa gcgctttgac      240

aaccccgtcc ttccgttcaa cgatggcgtc tatttcgcga gtacagagaa gtcaaatata      300

atccgcggct ggatatttgg cacaaccctc gatagtaaaa cacaatccct tctgatcgta      360

aataacgcaa cgaatgtggt gattaaggta tgcgagtttc aattttgcaa cgacccgttc      420

cttggcgttt attatcacaa aaataacaag tcctggatgg agtccgaatt cagagtgtat      480

tcttctgcca acaattgcac ctttgagtac gtgtcccagc ccttcttgat ggatctggaa      540

ggaaaacagg gcaatttcaa gaatttgaga gagttcgtct tcaaaaacat cgatggttat      600

tttaagatct atagcaagca caccccgata aacctcgtac gggaccttcc ccaggggttt      660

agcgcactgg agcctcttgt agatctcccg attggcatca atataaccag gtttcaaact      720

cttcttgcac ttcaccgaag ctatcttacg cccggcgata gctcttccgg ttggacagcc      780

ggcgccgcgg cctactatgt gggatatctc cagcctagaa cctttctgct taagtacaat      840

gaaaacggca ctattacaga cgccgtagat tgcgctctgg atcctcttag cgaaactaag      900

tgtactctga aatcttttac ggtagagaag ggaatttatc aaacaagtaa tttccgggta      960

caacccacag agagcatcgt ccggtttccg aacattacga atctttgccc gtttggcgaa     1020

gtcttcaatg caacacgctt cgcttccgtt tatgcgtgga atcgcaagag gatctctaac     1080

tgcgttgctg actacagtgt tctttataac agcgctagct tttctacatt caaatgttac     1140

ggggtaagcc ccaccaagct caacgacttg tgttttacca atgtttatgc ggattctttc     1200

gtgattcgcg gtgatgaagt taggcagatt gcgccaggac agactgggaa gattgccgac     1260

tataactata agctccctga cgacttcact gggtgtgtca ttgcttggaa cagcaacaat     1320

ctcgacagca aagttggagg caactataat tatctctacc ggctttttcg caagtctaac     1380

ctcaagccct tcgaaagaga catcagtact gagatctatc aagcaggaag cacgccatgc     1440

aacggtgtcg agggcttcaa ctgttatttt cctcttcaat cctacggctt tcaaccgaca     1500

aacggcgtcg gatatcagcc ttatcgagtc gttgtacttt ctttcgaact tctgcacgca     1560

ccagctactg tctgcgggcc taaaaaatct acaaacctgg tgaaaaataa atgcgttaat     1620

tttaatttta acggtttgac cggcaccggg gtccttactg agtcaaataa aaagttcctg     1680

ccgtttcagc agtttggccg cgatattgcc gatactacag acgcggtgcg ggaccctcaa     1740

actctcgaaa tcctggatat aacgccttgc tcttttggcg gggtaagcgt cattacccca     1800

ggtacaaata cgtcaaatca ggtcgctgtt ctgtaccaag acgtcaattg caccgaggtc     1860

ccagtagcta tccatgccga tcaactcacg ccaacctggc gggtatactc tacgggatcc     1920

aacgtcttcc aaaccagggc ggggtgcctc atcggagccg aacacgtaaa caatagctat     1980

gagtgcgata ttcccatagg ggccggaatc tgcgcttcat accaaaccca gactaattct     2040

ccccgacgag cccgaagcgt ggcatctcaa agcataatag cgtacacgat gagcttggga     2100

gcagaaaact cagtggcgta tagcaataac tccatcgcga taccaaccaa ttttacaatc     2160

agtgtgacta cagagatctt gccggttagt atgacaaaga cttcagtgga ttgcacgatg     2220

tacatctgtg gagatagtac cgagtgcagc aaccttttgt tgcagtatgg ctcattttgt     2280

acccaactca atcgggccct gaccggtatt gcagttgaac aggataaaaa cacacaagag     2340

gtctttgcac aagttaaaca aatatacaag accccgccta tcaaagactt tggtggtttt     2400

aattttagcc aaattcttcc cgacccgtca aagccgagta agcggtcatt catagaggat     2460

ctcctcttta ataaggtaac cttggctgac gcgggattta ttaaacagta cggtgactgt     2520

ttgggagata ttgcagctcg agacttgatc tgcgcccaga aattcaacgg tctgactgtt     2580

ttgcctccgc tcttgacgga cgagatgatc gcccagtata cttccgcctt gctcgctggt     2640

acgatcacct ccggctggac ctttggcgct ggagctgctc tccagatccc attcgcgatg     2700

cagatggctt accgatttaa cggtattggc gttacacaaa atgtattgta cgagaaccaa     2760

aaactcatcg ctaatcaatt caactcagct attggcaaaa ttcaagactc attgtcctct     2820

acagccagcg ccttgggtaa attgcaagac gtagtgaacc aaaatgcaca ggccttgaac     2880

actctggtca agcaactcag ttccaatttt ggtgcaatct catccgttct caacgatata     2940

ctgtctcgcc tggataaggt ggaagctgag gtgcaaatcg acagactcat aacgggaagg     3000

ctgcagagtc tgcagaccta tgtcactcag cagcttattc gagcggccga aatccgcgct     3060

tccgccaatt tggctgctac taaaatgagc gaatgcgtac tcgggcaatc taaacgagtc     3120

gacttttgtg gcaaaggcta ccacctcatg tcatttcccc agagtgcgcc acacggggtg     3180

gttttccttc atgtcaccta cgtgcccgcc caagaaaaga actttactac cgcaccggcc     3240

atctgccatg atggaaaggc ccatttcccg agagagggcg tatttgtctc aaacggtact     3300

cactggtttg tgacacaacg caatttctac gaaccccaaa ttataaccac tgacaacaca     3360

tttgtctctg gaaactgtga tgtcgttatt ggtatagtta acaacacggt ctacgaccca     3420

ctccagccag agctggactc ttttaaagaa gaactcgaca agtattttaa aaatcacacg     3480

agtcccgacg ttgaccttgg agacattagt gggatcaacg cgagtgtcgt taacatccaa     3540

aaggagattg atcgcctcaa tgaggtggcc aagaatctca acgaatccct catagatctc     3600

caagagctcg gtaagtatga gcagtatatt aagtggccct ggtatatatg gctcggcttt     3660

atcgccggcc tgattgcaat agttatggtt acgataatgc tgtgctgtat gacttcatgc     3720

tgttcttgtt tgaaaggctg ttgctcatgt gggagttgtt gcaagtttga tgaggacgac     3780

agtgaacccg tattgaaggg tgtgaagctt cattacactt aa                        3822


<210>  3
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  3

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser 
1               5                   10              


<210>  4
<211>  305
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  4

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe 
305 


<210>  5
<211>  192
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  5

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


<210>  6
<211>  698
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  6

Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
1               5                   10                  15      


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
            20                  25                  30          


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
        35                  40                  45              


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
    50                  55                  60                  


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
65                  70                  75                  80  


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
                85                  90                  95      


Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val 
            100                 105                 110         


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
        115                 120                 125             


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
    130                 135                 140                 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
145                 150                 155                 160 


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser 
                165                 170                 175     


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu 
            180                 185                 190         


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
        195                 200                 205             


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
    210                 215                 220                 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
225                 230                 235                 240 


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
                245                 250                 255     


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
            260                 265                 270         


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
        275                 280                 285             


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
    290                 295                 300                 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
305                 310                 315                 320 


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
                325                 330                 335     


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
            340                 345                 350         


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
        355                 360                 365             


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
    370                 375                 380                 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
385                 390                 395                 400 


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
                405                 410                 415     


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
            420                 425                 430         


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
        435                 440                 445             


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
    450                 455                 460                 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu 
465                 470                 475                 480 


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
                485                 490                 495     


Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala 
            500                 505                 510         


Asn Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys 
        515                 520                 525             


Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln 
    530                 535                 540                 


Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala 
545                 550                 555                 560 


Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys 
                565                 570                 575     


Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp 
            580                 585                 590         


Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp 
        595                 600                 605             


Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn 
    610                 615                 620                 


Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu 
625                 630                 635                 640 


Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu 
                645                 650                 655     


Gly Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu 
            660                 665                 670         


Ile Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile 
        675                 680                 685             


Asp Leu Gln Glu Leu Gly Lys Tyr Glu Gln 
    690                 695             


<210>  7
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  7

Tyr Ile Lys Trp Pro Trp Tyr 
1               5           


<210>  8
<211>  58
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  8

Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr 
1               5                   10                  15      


Ile Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys 
            20                  25                  30          


Cys Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro 
        35                  40                  45              


Val Leu Lys Gly Val Lys Leu His Tyr Thr 
    50                  55              


<210>  9
<211>  3629
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  9
atgtttgtgt tcctggtgct tctgccactt gtttcctcac aatgcgtcaa tctcacaaca       60

agaacgcagc ttccgcctgc atatacaaat agtttcacca gaggcgttta ttatccagat      120

aaggtctttc gaagctctgt cctccattct acgcaagatc tgttcttgcc attcttttca      180

aacgtgacgt ggtttcacgc tattcacgtt tctggcacta atggcacgaa gcgctttgac      240

aaccccgtcc ttccgttcaa cgatggcgtc tatttcgcga gtacagagaa gtcaaatata      300

atccgcggct ggatatttgg cacaaccctc gatagtaaaa cacaatccct tctgatcgta      360

aataacgcaa cgaatgtggt gattaaggta tgcgagtttc aattttgcaa cgacccgttc      420

cttggcgttt attatcacaa aaataacaag tcctggatgg agtccgaatt cagagtgtat      480

tcttctgcca acaattgcac ctttgagtac gtgtcccagc ccttcttgat ggatctggaa      540

ggaaaacagg gcaatttcaa gaatttgaga gagttcgtct tcaaaaacat cgatggttat      600

tttaagatct atagcaagca caccccgata aacctcgtac gggaccttcc ccaggggttt      660

agcgcactgg agcctcttgt agatctcccg attggcatca atataaccag gtttcaaact      720

cttcttgcac ttcaccgaag ctatcttacg cccggcgata gctcttccgg ttggacagcc      780

ggcgccgcgg cctactatgt gggatatctc cagcctagaa cctttctgct taagtacaat      840

gaaaacggca ctattacaga cgccgtagat tgcgctctgg atcctcttag cgaaactaag      900

tgtactctga aatcttttac ggtagagaag ggaatttatc aaacaagtaa tttccgggta      960

caacccacag agagcatcgt ccggtttccg aacattacga atctttgccc gtttggcgaa     1020

gtcttcaatg caacacgctt cgcttccgtt tatgcgtgga atcgcaagag gatctctaac     1080

tgcgttgctg actacagtgt tctttataac agcgctagct tttctacatt caaatgttac     1140

ggggtaagcc ccaccaagct caacgacttg tgttttacca atgtttatgc ggattctttc     1200

gtgattcgcg gtgatgaagt taggcagatt gcgccaggac agactgggaa gattgccgac     1260

tataactata agctccctga cgacttcact gggtgtgtca ttgcttggaa cagcaacaat     1320

ctcgacagca aagttggagg caactataat tatctctacc ggctttttcg caagtctaac     1380

ctcaagccct tcgaaagaga catcagtact gagatctatc aagcaggaag cacgccatgc     1440

aacggtgtcg agggcttcaa ctgttatttt cctcttcaat cctacggctt tcaaccgaca     1500

aacggcgtcg gatatcagcc ttatcgagtc gttgtacttt ctttcgaact tctgcacgca     1560

ccagctactg tctgcgggcc taaaaaatct acaaacctgg tgaaaaataa atgcgttaat     1620

tttaatttta acggtttgac cggcaccggg gtccttactg agtcaaataa aaagttcctg     1680

ccgtttcagc agtttggccg cgatattgcc gatactacag acgcggtgcg ggaccctcaa     1740

actctcgaaa tcctggatat aacgccttgc tcttttggcg gggtaagcgt cattacccca     1800

ggtacaaata cgtcaaatca ggtcgctgtt ctgtaccaag acgtcaattg caccgaggtc     1860

ccagtagcta tccatgccga tcaactcacg ccaacctggc gggtatactc tacgggatcc     1920

aacgtcttcc aaaccagggc ggggtgcctc atcggagccg aacacgtaaa caatagctat     1980

gagtgcgata ttcccatagg ggccggaatc tgcgcttcat accaaaccca gactaattct     2040

ccccgacgag cccgaagcgt ggcatctcaa agcataatag cgtacacgat gagcttggga     2100

gcagaaaact cagtggcgta tagcaataac tccatcgcga taccaaccaa ttttacaatc     2160

agtgtgacta cagagatctt gccggttagt atgacaaaga cttcagtgga ttgcacgatg     2220

tacatctgtg gagatagtac cgagtgcagc aaccttttgt tgcagtatgg ctcattttgt     2280

acccaactca atcgggccct gaccggtatt gcagttgaac aggataaaaa cacacaagag     2340

gtctttgcac aagttaaaca aatatacaag accccgccta tcaaagactt tggtggtttt     2400

aattttagcc aaattcttcc cgacccgtca aagccgagta agcggtcatt catagaggat     2460

ctcctcttta ataaggtaac cttggctgac gcgggattta ttaaacagta cggtgactgt     2520

ttgggagata ttgcagctcg agacttgatc tgcgcccaga aattcaacgg tctgactgtt     2580

ttgcctccgc tcttgacgga cgagatgatc gcccagtata cttccgcctt gctcgctggt     2640

acgatcacct ccggctggac ctttggcgct ggagctgctc tccagatccc attcgcgatg     2700

cagatggctt accgatttaa cggtattggc gttacacaaa atgtattgta cgagaaccaa     2760

aaactcatcg ctaatcaatt caactcagct attggcaaaa ttcaagactc attgtcctct     2820

acagccagcg ccttgggtaa attgcaagac gtagtgaacc aaaatgcaca ggccttgaac     2880

actctggtca agcaactcag ttccaatttt ggtgcaatct catccgttct caacgatata     2940

ctgtctcgcc tggataaggt ggaagctgag gtgcaaatcg acagactcat aacgggaagg     3000

ctgcagagtc tgcagaccta tgtcactcag cagcttattc gagcggccga aatccgcgct     3060

tccgccaatt tggctgctac taaaatgagc gaatgcgtac tcgggcaatc taaacgagtc     3120

gacttttgtg gcaaaggcta ccacctcatg tcatttcccc agagtgcgcc acacggggtg     3180

gttttccttc atgtcaccta cgtgcccgcc caagaaaaga actttactac cgcaccggcc     3240

atctgccatg atggaaaggc ccatttcccg agagagggcg tatttgtctc aaacggtact     3300

cactggtttg tgacacaacg caatttctac gaaccccaaa ttataaccac tgacaacaca     3360

tttgtctctg gaaactgtga tgtcgttatt ggtatagtta acaacacggt ctacgaccca     3420

ctccagccag agctggactc ttttaaagaa gaactcgaca agtattttaa aaatcacacg     3480

agtcccgacg ttgaccttgg agacattagt gggatcaacg cgagtgtcgt taacatccaa     3540

aaggagattg atcgcctcaa tgaggtggcc aagaatctca acgaatccct catagatctc     3600

caagagctcg gtaagtatga gcagtataa                                       3629


<210>  10
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  10

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser 
1               5                   10              


<210>  11
<211>  305
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  11

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe 
305 


<210>  12
<211>  192
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  12

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


<210>  13
<211>  698
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  13

Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
1               5                   10                  15      


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
            20                  25                  30          


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
        35                  40                  45              


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
    50                  55                  60                  


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
65                  70                  75                  80  


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
                85                  90                  95      


Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val 
            100                 105                 110         


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
        115                 120                 125             


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
    130                 135                 140                 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
145                 150                 155                 160 


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser 
                165                 170                 175     


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu 
            180                 185                 190         


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
        195                 200                 205             


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
    210                 215                 220                 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
225                 230                 235                 240 


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
                245                 250                 255     


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
            260                 265                 270         


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
        275                 280                 285             


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
    290                 295                 300                 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
305                 310                 315                 320 


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
                325                 330                 335     


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
            340                 345                 350         


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
        355                 360                 365             


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
    370                 375                 380                 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
385                 390                 395                 400 


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
                405                 410                 415     


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
            420                 425                 430         


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
        435                 440                 445             


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
    450                 455                 460                 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu 
465                 470                 475                 480 


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
                485                 490                 495     


Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala 
            500                 505                 510         


Asn Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys 
        515                 520                 525             


Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln 
    530                 535                 540                 


Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala 
545                 550                 555                 560 


Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys 
                565                 570                 575     


Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp 
            580                 585                 590         


Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp 
        595                 600                 605             


Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn 
    610                 615                 620                 


Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu 
625                 630                 635                 640 


Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu 
                645                 650                 655     


Gly Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu 
            660                 665                 670         


Ile Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile 
        675                 680                 685             


Asp Leu Gln Glu Leu Gly Lys Tyr Glu Gln 
    690                 695             


<210>  14
<211>  582
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  14
atgcgggtac aacccacaga gagcatcgtc cggtttccga acattacgaa tctttgcccg       60

tttggcgaag tcttcaatgc aacacgcttc gcttccgttt atgcgtggaa tcgcaagagg      120

atctctaact gcgttgctga ctacagtgtt ctttataaca gcgctagctt ttctacattc      180

aaatgttacg gggtaagccc caccaagctc aacgacttgt gttttaccaa tgtttatgcg      240

gattctttcg tgattcgcgg tgatgaagtt aggcagattg cgccaggaca gactgggaat      300

attgccgact ataactataa gctccctgac gacttcactg ggtgtgtcat tgcttggaac      360

agcaacaatc tcgacagcaa agttggaggc aactataatt atctctaccg gctttttcgc      420

aagtctaacc tcaagccctt cgaaagagac atcagtactg agatctatca agcaggaagc      480

acgccatgca acggtgtcaa gggcttcaac tgttattttc ctcttcaatc ctacggcttt      540

caaccgacat acggcgtcgg atatcagcct tatcgagtct aa                         582


<210>  15
<211>  170
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  15
gtggcgatcc tgccctcatc cgtctcgctt attcggggag cggacgatga ccctagtaga       60

gggggctgcg gcttaggagg gcagaagctg agtggcgtcg gagggagctc tactgcaggg      120

agcccagata ccctaccgag aactcagaga gtcgttggaa gacgggaagg                 170


<210>  16
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  16
cctgaatgga ctacgacata gtctagtccg ccaag                                  35


<210>  17
<211>  1208
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  17

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln 
    1205             


